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https://www.readbyqxmd.com/read/28102924/current-practices-related-to-family-presence-during-acute-deterioration-in-adult-emergency-department-patients
#1
Megan J Youngson, Judy Currey, Julie Considine
AIMS: To explore the characteristics and interactions of clinicians, patients and family members during management of the deteriorating adult patient in the Emergency Department. BACKGROUND: Previous research into family presence during resuscitation has identified many positive outcomes when families are included. However, over that last three decades the epidemiology of acute clinical deterioration has changed, with a decrease in in-hospital cardiac arrests and an increase in acute clinical deterioration...
January 19, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28102556/structurally-stable-attractive-nanoscale-emulsions-with-dipole-dipole-interaction-driven-interdrop-percolation
#2
Kyounghee Shin, Gyeonghyeon Gong, Jonas Cuadrado, Serim Jeon, Mintae Seo, Hong Sung Choi, Jae Sung Hwang, Youngbok Lee, Alberto Fernandez-Nieves, Jin Woong Kim
This study introduces an extremely stable attractive nanoscale emulsion fluid, in which the amphiphilic block copolymer, poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL), is tightly packed with lecithin, thereby forming a mechanically robust thin-film at the oil-water interface. The molecular association of PEO-b-PCL with lecithin is critical for formation of a tighter and denser molecular assembly at the interface, which is systematically confirmed by T2 relaxation and DSC analyses. Moreover, our suspension rheology studies also reflect the interdroplet attractions over a wide volume fraction range of the dispersed oil phase; this results in a percolated network of stable drops that exhibit no signs of coalescence or phase separation...
January 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28098315/a-ph-responsive-wormlike-micellar-system-of-a-noncovalent-interaction-based-surfactant-with-a-tunable-molecular-structure
#3
Wanli Kang, Pengxiang Wang, Haiming Fan, Hongbin Yang, Caili Dai, Xia Yin, Yilu Zhao, Shujun Guo
Responsive wormlike micelles are very useful in a number of applications, whereas it is still challenging to create dramatic viscosity changes in wormlike micellar systems. Here we developed a pH-responsive wormlike micellar system based on a noncovalent constructed surfactant, which is formed by the complexation of N-erucamidopropyl-N,N-dimethylamine (UC22AMPM) and citric acid at the molar ratio of 3 : 1 (EACA). The phase behavior, aggregate microstructure and viscoelasticity of EACA solutions were investigated by macroscopic appearance observation, rheological and cryo-TEM measurements...
January 18, 2017: Soft Matter
https://www.readbyqxmd.com/read/28058439/phase-diagram-of-heteronuclear-janus-dumbbells
#4
Patrick O'Toole, Achille Giacometti, Toby Hudson
Using aggregation-volume-bias Monte Carlo simulations along with successive umbrella sampling and histogram re-weighting, we study the phase diagram of a system of dumbbells formed by two touching spheres having variable sizes, as well as different interaction properties. The first sphere (h) interacts with all other spheres belonging to different dumbbells with a hard-sphere potential. The second sphere (s) interacts via a square-well interaction with other s spheres belonging to different dumbbells and with a hard-sphere potential with all remaining h spheres...
January 6, 2017: Soft Matter
https://www.readbyqxmd.com/read/28057793/protein-interactions-at-endothelial-junctions-and-signaling-mechanisms-regulating-endothelial-permeability
#5
REVIEW
Yulia A Komarova, Kevin Kruse, Dolly Mehta, Asrar B Malik
The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in all tissue except the relatively impermeable blood-brain and inner retinal barriers) that regulates tissue-fluid homeostasis, transport of nutrients, and migration of blood cells across the barrier. Permeability of the endothelial barrier is primarily regulated by a protein complex called adherens junctions. Adherens junctions are not static structures; they are continuously remodeled in response to mechanical and chemical cues in both physiological and pathological settings...
January 6, 2017: Circulation Research
https://www.readbyqxmd.com/read/28054600/stochastic-kinetics-reveal-imperative-role-of-anisotropic-interfacial-tension-to-determine-morphology-and-evolution-of-nucleated-droplets-in-nematogenic-films
#6
Amit Kumar Bhattacharjee
For isotropic fluids, classical nucleation theory predicts the nucleation rate, barrier height and critical droplet size by ac- counting for the competition between bulk energy and interfacial tension. The nucleation process in liquid crystals is less understood. We numerically investigate nucleation in monolayered nematogenic films using a mesoscopic framework, in par- ticular, we study the morphology and kinetic pathway in spontaneous formation and growth of droplets of the stable phase in the metastable background...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28054366/the-role-of-molecular-pain-biomarkers-in-temporomandibular-joint-internal-derangement
#7
REVIEW
Malin Ernberg
There is evidence that low-grade inflammation may be responsible for pain and development of degenerative changes in temporomandibular joint internal derangement. This article reviews the current knowledge of the molecular mechanisms behind TMJ internal derangements. A non-systematic search was carried out in PubMed, Embase, and the Cochrane library for studies regarding pathophysiological mechanisms behind internal derangements focusing on pain mediating inflammatory and cartilage degrading molecules. Recent data suggests that release of cytokines may be the key event for pain and cartilage destruction in TMJ internal derangements...
January 5, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28049334/anomalous-diffusion-and-diffusion-anomaly-in-confined-janus-dumbbells
#8
Leandro B Krott, Cristina Gavazzoni, José Rafael Bordin
Self-assembly and dynamical properties of Janus nanoparticles have been studied by molecular dynamic simulations. The nanoparticles are modeled as dimers and they are confined between two flat parallel plates to simulate a thin film. One monomer from the dumbbells interacts by a standard Lennard-Jones potential and the other by a two-length scales shoulder potential, typically used for anomalous fluids. Here, we study the effects of removing the Brownian effects, typical from colloidal systems immersed in aqueous solution, and consider a molecular system, without the drag force and the random collisions from the Brownian motion...
December 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28036182/shape-induced-deformation-capillary-bridging-and-self-assembly-of-cuboids-at-the-fluid-fluid-interface
#9
Thriveni G Anjali, Madivala G Basavaraj
The controlled assembly of anisotropic particles through shape-induced interface deformations is shown to be a potential route for the fabrication of novel functional materials. In this article, the shape-induced interface deformation, capillary bridging, and directed self-assembly of cuboidal-shaped hematite particles at fluid-fluid interfaces are reported. The multipolar nature of the interface distortions is directly visualized using high-resolution scanning electron microscopy and 3D optical surface profiling...
January 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28036019/lymph-nodes-and-cancer-metastasis-new-perspectives-on-the-role-of-intranodal-lymphatic-sinuses
#10
REVIEW
Rui-Cheng Ji
The lymphatic system is essential for transporting interstitial fluid, soluble antigen, and immune cells from peripheral tissues to lymph nodes (LNs). Functional integrity of LNs is dependent on intact lymphatics and effective lymph drainage. Molecular mechanisms that facilitate interactions between tumor cells and lymphatic endothelial cells (LECs) during tumor progression still remain to be identified. The cellular and molecular structures of LNs are optimized to trigger a rapid and efficient immune response, and to participate in the process of tumor metastasis by stimulating lymphangiogenesis and establishing a premetastatic niche in LNs...
December 28, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28034672/effects-of-cytoskeletal-drugs-on-actin-cortex-elasticity
#11
Yareni A Ayala, Bruno Pontes, Barbara Hissa, Ana Carolina M Monteiro, Marcos Farina, Vivaldo Moura-Neto, Nathan B Viana, H Moysés Nussenzveig
Mechanical properties of cells are known to be influenced by the actin cytoskeleton. In this article, the action of drugs that interact with the actin cortex is investigated by tether extraction and rheology experiments using optical tweezers. The influences of Blebbistatin, Cytochalasin D and Jasplakinolide on the cell mechanical properties are evaluated. The results, in contradiction to current views for Jasplakinolide, show that all three drugs and treatments destabilize the actin cytoskeleton, decreasing the cell membrane tension...
December 26, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/28033184/effect-of-outflow-graft-size-on-flow-in-the-aortic-arch-and-cerebral-blood-flow-in-continuous-flow-pumps-possible-relevance-to-strokes
#12
Sindhoor Bhat, Jayakala Mathews, Komrakshi R Balakrishnan, Ramarathnam Krishna Kumar
One of the most devastating complications of continuous flow left ventricular devices (CFLVADS) is a stroke, with a higher incidence in Heartware HVAD as compared to HEARTMATE II. The reason for the observed difference in stroke rates is unclear. Since outflow graft diameters are different, we hypothesized that this could contribute to the difference in stroke rates.A Computational fluid structure interaction model was created from the CT scan of a patient. Pressures were used as the boundary condition and the flow through the cerebral vessels was derived as outputs...
December 26, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28030363/new-dimensions-of-connectomics-and-network-plasticity-in-the-central-nervous-system
#13
Diego Guidolin, Manuela Marcoli, Guido Maura, Luigi F Agnati
Cellular network architecture plays a crucial role as the structural substrate for the brain functions. Therefore, it represents the main rationale for the emerging field of connectomics, defined as the comprehensive study of all aspects of central nervous system connectivity. Accordingly, in the present paper the main emphasis will be on the communication processes in the brain, namely wiring transmission (WT), i.e. the mapping of the communication channels made by cell components such as axons and synapses, and volume transmission (VT), i...
December 28, 2016: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28024148/solution-structure-of-discoidal-high-density-lipoprotein-particles-with-a-shortened-apolipoprotein-a-i
#14
Stefan Bibow, Yevhen Polyhach, Cédric Eichmann, Celestine N Chi, Julia Kowal, Stefan Albiez, Robert A McLeod, Henning Stahlberg, Gunnar Jeschke, Peter Güntert, Roland Riek
High-density lipoprotein (HDL) particles are cholesterol and lipid transport containers. Mature HDL particles destined for the liver develop through the formation of intermediate discoidal HDL particles, which are the primary acceptors for cholesterol. Here we present the three-dimensional structure of reconstituted discoidal HDL (rdHDL) particles, using a shortened construct of human apolipoprotein A-I, determined from a combination of nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR) and transmission electron microscopy (TEM) data...
December 26, 2016: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28017521/the-ciliopathy-associated-cep104-protein-interacts-with-tubulin-and-nek1-kinase
#15
Caezar Al-Jassar, Antonina Andreeva, Deepak D Barnabas, Stephen H McLaughlin, Christopher M Johnson, Minmin Yu, Mark van Breugel
Cilia are thin cell projections with essential roles in cell motility, fluid movement, sensing, and signaling. They are templated from centrioles that dock against the plasma membrane and subsequently extend their peripheral microtubule array. The molecular mechanisms underpinning cilia assembly are incompletely understood. Cep104 is a key factor involved in cilia formation and length regulation that rides on the ends of elongating and shrinking cilia. It is mutated in Joubert syndrome, a genetically heterogeneous ciliopathy...
January 3, 2017: Structure
https://www.readbyqxmd.com/read/28003212/subfornical-organ-neurons-integrate-cardiovascular-and-metabolic-signals
#16
Nicole M Cancelliere, Alastair V Ferguson
The subfornical organ (SFO) is a critical circumventricular organ involved in the control of cardiovascular and metabolic homeostasis. Despite the plethora of circulating signals continuously sensed by the SFO, studies investigating how these signals are integrated are lacking. In this study, we use patch clamp techniques to investigate how the traditionally classified 'cardiovascular' hormone angiotensin II (ANG), 'metabolic' hormone cholecystokinin (CCK) and 'metabolic' signal glucose interact and are integrated in the SFO...
December 21, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28001160/photoluminescence-and-electroluminescence-of-cationic-ptau2-heterotrinuclear-complexes-with-aromatic-acetylides
#17
Li-Yi Zhang, Liang-Jin Xu, Jin-Yun Wang, Xian-Chong Zeng, Zhong-Ning Chen
Cationic PtAu2 heterotrinuclear complexes [PtAu2(dpmp)2(C[triple bond, length as m-dash]CR)2](2+) (dpmp = bis(diphenylphosphinomethyl)phenylphosphine, R = aryl) of aromatic acetylides were prepared. The PtAu2 structures are supported through doubly bridging dpmp and stabilized by a significant Pt-Au interaction. They are highly phosphorescent in fluid CH2Cl2 solution (Φem = 23.5%-78.9%), the solid state (Φem = 15.4%-70.2%), the PMMA film (Φem = 39.9%-71.7%) and the doping film of 61% TCTA : 31% OXD-7 : 8% PtAu2 complex (Φem = 16...
December 21, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27996264/characterizing-structural-complexity-in-disordered-carbons-from-the-slit-pore-to-atomistic-models
#18
Suresh K Bhatia
The reliable characterization of nanoporous carbons is critical to the design and optimization of their numerous applications; however, the vast majority of carbons in industrial use are highly disordered, with complex structures whose understanding has long challenged researchers. The idealized slit pore model represents the most commonly used approximation to a carbon nanopore; nevertheless, it has been only partially successful in predicting adsorption isotherms and fails significantly in predicting transport properties because of its inability to capture structural disorder and its effect on fluid accessibility...
December 20, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27995899/passive-mechanism-of-pitch-recoil-in-flapping-insect-wings
#19
D Ishihara, T Horie
The high torsional flexibility of insect wings allows for elastic recoil after the rotation of the wing during stroke reversal. However, the underlying mechanism of this recoil remains unclear because of the dynamic process of transitioning from the wing rotation during stroke reversal to the maintenance of a high angle of attack during the middle of each half-stroke, when the inertial, elastic, and aerodynamic effects all have a significant impact. Therefore, the interaction between the flapping wing and the surrounding air was directly simulated by simultaneously solving the incompressible Navier-Stokes equations, the equation of motion for an elastic body, and the fluid-structure interface conditions using the three-dimensional finite element method...
December 20, 2016: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/27994459/the-nasal-delivery-of-nanoencapsulated-statins-an-approach-for-brain-delivery
#20
Adryana Clementino, Mellissa Batger, Gabriela Garrastazu, Michele Pozzoli, Elena Del Favero, Valeria Rondelli, Bianca Gutfilen, Thiago Barboza, Maria B Sukkar, Sergio A L Souza, Laura Cantù, Fabio Sonvico
PURPOSE: Along with their cholesterol-lowering effect, statins have shown a wide range of pleiotropic effects potentially beneficial to neurodegenerative diseases. However, such effects are extremely elusive via the conventional oral administration. The purpose of the present study was to prepare and characterize the physicochemical properties and the in vivo biodistribution of simvastatin-loaded lecithin/chitosan nanoparticles (SVT-LCNs) suitable for nasal administration in view of an improved delivery of the statins to the brain...
2016: International Journal of Nanomedicine
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