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https://www.readbyqxmd.com/read/29334240/new-method-for-estimating-arterial-pulse-wave-velocity-at-single-site
#1
Khaled Ben Abdessalem, Patrice Flaud, Samir Zobaidi
The clinical importance of measuring local pulse wave velocity (PWV), has encouraged researchers to develop several local methods to estimate it. In this work, we proposed a new method, the sum-of-squares method [Formula: see text], that allows the estimations of PWV by using simultaneous measurements of blood pressure (P) and arterial diameter (D) at single-location. Pulse waveforms generated by: (1) two-dimensional (2D) fluid-structure interaction simulation (FSI) in a compliant tube, (2) one-dimensional (1D) model of 55 larger human systemic arteries and (3) experimental data were used to validate the new formula and evaluate several classical methods...
January 15, 2018: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/29332565/beyond-the-lock-and-key-paradigm-targeting-lipid-rafts-to-induce-the-selective-apoptosis-of-cancer-cells
#2
Anna Carolina Schneider Alves, Reinaldo Antonio Dias, Luciano Porto Kagami, Gustavo Machado das Neves, Fernando Cidade Torres, Vera Lucia Eifler-Lima, Ivone Carvalho, Carolina de Miranda Silva, Daniel Fabio Kawano
For more than 40 years, the fluid mosaic model of cellular membranes have supported our vision of an inert lipid bilayer containing membrane protein receptors that are randomly hit by extracellular molecules to trigger intracellular signaling events. However, the notion that compartmentalized cholesterol- and sphingomyelin-rich membrane microdomains (known as lipid rafts) spatially arrange receptors and effectors to promote kinetically favorable interactions necessary for the signal transduction sounds much more realistic...
January 10, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29331126/binding-branched-and-linear-dna-structures-from-isolated-clusters-to-fully-bonded-gels
#3
J Fernandez-Castanon, F Bomboi, F Sciortino
The proper design of DNA sequences allows for the formation of well-defined supramolecular units with controlled interactions via a consecution of self-assembling processes. Here, we benefit from the controlled DNA self-assembly to experimentally realize particles with well-defined valence, namely, tetravalent nanostars (A) and bivalent chains (B). We specifically focus on the case in which A particles can only bind to B particles, via appropriately designed sticky-end sequences. Hence AA and BB bonds are not allowed...
January 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29328657/molecular-mechanism-of-protein-unfolding-under-shear-a-lattice-boltzmann-molecular-dynamics-study
#4
Fabio Sterpone, Philippe Derreumaux, Simone Melchionna
Proteins are marginally stable soft-matter entities that can be disrupted using a variety of perturbative stresses, including thermal, chemicals or mechanical ones. Fluid under extreme flow conditions is a possible route to probe the weakness of biomolecules and collect information on the molecular cohesive interactions that secure their stability. Moreover, in many cases, physiological flow triggers the functional response of specialised proteins as occurring in blood coagulation or cell adhesion. In this paper, we deploy the Lattice Boltzmann Molecular Dynamics technique based on the coarse grained model for protein OPEP, to study the mechanism of protein unfolding under Couette flow...
January 12, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29323916/influence-of-eugenol-on-the-organization-and-dynamics-of-lipid-membranes-a-phase-dependent-study
#5
Geetanjali Meher, Hirak Chakraborty
Eugenol is known for its antimicrobial effects against microorganisms responsible for infectious diseases in human, food borne pathogens and oral pathogens. In spite of several reports on the antimicrobial function of eugenol by modulating the structural properties of cell membrane there was no direct information on the influence of eugenol in the lipid membrane. In this work, we explored the effect of eugenol on organization and dynamics of large unilamellar vesicles (LUVs) of DMPC using the intrinsic fluorescence of eugenol and an extrinsic hydrophobic probe, DPH, in varying phases...
January 11, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29322335/mechanobiological-modeling-of-endochondral-ossification-an-experimental-and-computational-analysis
#6
J J Vaca-González, M Moncayo-Donoso, J M Guevara, Y Hata, S J Shefelbine, D A Garzón-Alvarado
Long bone formation starts early during embryonic development through a process known as endochondral ossification. This is a highly regulated mechanism that involves several mechanical and biochemical factors. Because long bone development is an extremely complex process, it is unclear how biochemical regulation is affected when dynamic loads are applied, and also how the combination of mechanical and biochemical factors affect the shape acquired by the bone during early development. In this study, we develop a mechanobiological model combining: (1) a reaction-diffusion system to describe the biochemical process and (2) a poroelastic model to determine the stresses and fluid flow due to loading...
January 10, 2018: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29322329/in-vitro-validation-of-a-numerical-simulation-of-leaflet-kinematics-in-a-polymeric-aortic-valve-under-physiological-conditions
#7
Saleh Hassanzadeh Gharaie, Bobak Mosadegh, Yosry Morsi
This paper describes a computational method to simulate the non-linear structural deformation of a polymeric aortic valve under physiological conditions. Arbitrary Lagrangian-Eulerian method is incorporated in the fluid-structure interaction simulation, and then validated by comparing the predicted kinematics of the valve's leaflets to in vitro measurements on a custom-made polymeric aortic valve. The predicted kinematics of the valve's leaflets was in good agreement with the experimental results with a maximum error of 15% in a single cardiac cycle...
January 10, 2018: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29319373/clinical-learning-spaces-crucibles-for-practice-development-in-physiotherapy-clinical-education
#8
Narelle Patton, Joy Higgs, Megan Smith
This paper, through a deep examination of clinical workplaces as learning spaces, uses a holistic interpretation of clinical education and offers a practice development crucible metaphor as a useful way to deepen how clinical education can be conceptualized. An in-depth conceptualization of clinical education is needed if educators are able to develop wise educational practice and optimize the time students spend in clinical learning settings. The research reported here was undertaken in the qualitative paradigm guided by philosophical hermeneutics...
January 10, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29319100/activity-induced-instability-of-phonons-in-1d-microfluidic-crystals
#9
Alan Cheng Hou Tsang, Michael J Shelley, Eva Kanso
One-dimensional crystals of passively-driven particles in microfluidic channels exhibit collective vibrational modes reminiscent of acoustic 'phonons'. These phonons are induced by the long-range hydrodynamic interactions among the particles and are neutrally stable at the linear level. Here, we analyze the effect of particle activity - self-propulsion - on the emergence and stability of these phonons. We show that the direction of wave propagation in active crystals is sensitive to the intensity of the background flow...
January 10, 2018: Soft Matter
https://www.readbyqxmd.com/read/29317326/study-of-the-upper-airway-of-obstructive-sleep-apnea-patient-using-fluid-structure-interaction
#10
Yang Liu, Jennifer Mitchell, Yitung Chen, Woosoon Yim, Wenxiao Chu, Robert C Wang
Up to 14% of the U.S. population is estimated to have obstructive sleep apnea (OSA), while the outcomes of the treatments have variable results. In the current study, a three-dimensional fluid-structure interaction modeling was applied to simulate the upper airway to identify the precise location, severity, and characteristic of airway collapse. This was accomplished using Simpleware® and ANSYS® software applied to a 3-D rendering of the airway in a real patient with severe OSA. During this simulation, areas which are prone to collapse and precipitate apneic episodes were identified at the tip of the soft palate and the base of the tongue, with intrathoracic pressure as low as -1370 Pa...
January 6, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29316355/finite-element-models-of-flagella-with-sliding-radial-spokes-and-inter-doublet-links-exhibit-propagating-waves-under-steady-dynein-loading
#11
Tianchen Hu, Philip V Bayly
It remains unclear how flagella generate propulsive, oscillatory waveforms. While it is well known that dynein motors, in combination with passive cytoskeletal elements, drive the bending of the axoneme by applying shearing forces and bending moments to microtubule doublets, the origin of rhythmicity is still mysterious. Most conceptual models of flagellar oscillation involve dynein regulation or switching, so that dynein activity first on one side of the axoneme, then the other, drives bending. In contrast, a "viscoelastic flutter" mechanism has recently been proposed, based on a dynamic structural instability...
January 5, 2018: Cytoskeleton
https://www.readbyqxmd.com/read/29316116/exploring-molecular-and-thermodynamic-properties-of-zwitterions-vs-ionic-liquids-a-comprehensive-computational-analysis-to-develop-advanced-separation-processes
#12
Daniel Moreno, Maria Gonzalez-Miquel, Victor R Ferro, Jose Palomar
Zwitterions ionic liquids (ZIs) are compounds in which both counterions are covalently tethered, conferring them with unique characteristics; however, most of their properties are still unknown, remaining a bottleneck to exploit practical applications. Herein, molecular and fluid properties of ZIs and their mixtures are explored by means of quantum chemical analysis based on density functional theory (DFT) and COSMO-RS method, and compared against homologous ILs, to provide a comprehensive overview on the effect of the distinct structures on their physicochemical and thermodynamic behavior...
January 7, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29305610/flow-structure-interaction-simulations-of-the-aortic-heart-valve-at-physiologic-conditions-the-role-of-tissue-constitutive-model
#13
Anvar Gilmanov, Henryk Stolarski, Fotis Sotiropoulos
The blood flow patterns in the region around the aortic valve depend on the geometry of the aorta and on the complex flow-structure interaction between the pulsatile flow and the valve leaflets. Consequently, the flow depends strongly on the constitutive properties of the tissue, which can be expected to vary between healthy and diseased heart valves or native and prosthetic valves. In this work we seek to demonstrate the role of tissue constitutive model on aortic valve hemodynamics. We employ the Curvilinear Immersed Boundary - Finite Element - Fluid Structure Interaction (CURVIB-FE-FSI) method developed by Gilmanov et al...
January 5, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29303275/elastocapillary-driven-assembly-of-particles-at-free-standing-smectic-a-films
#14
Mohamed Amine Gharbi, Daniel A Beller, Nima Sharifi Mood, Rohini Gupta, Randall D Kamien, Shu Yang, Kathleen J Stebe
Colloidal particles at complex fluid interfaces and within films assemble to form ordered structures with high degrees of symmetry via interactions that include capillarity, elasticity, and other fields like electrostatic charge. Here we study microparticle interactions within free-standing smectic-A films, in which the elasticity arising from the director field distortion and capillary interactions arising from interface deformation compete to direct concomitantly the assembly of motile particles. New colloidal assemblies and patterns, ranging from 1D chains to 2D aggregates, sensitive to the initial wetting conditions of particles at the smectic film, are reported...
January 5, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29299703/membrane-undulations-in-a-structured-fluid-universal-dynamics-at-intermediate-length-and-time-scales
#15
Rony Granek, Haim Diamant
The dynamics of membrane undulations inside a viscous solvent is governed by distinctive, anomalous, power laws. Inside a viscoelastic continuous medium these universal behaviors are modified by the specific bulk viscoelastic spectrum. Yet, in structured fluids the continuum limit is reached only beyond a characteristic correlation length. We study the crossover to this asymptotic bulk dynamics. The analysis relies on a recent generalization of the hydrodynamic interaction in structured fluids, which shows a slow spatial decay of the interaction toward the bulk limit...
January 5, 2018: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/29299134/proteomic-changes-in-cerebrospinal-fluid-from-primary-central-nervous-system-lymphoma-patients-are-associated-with-protein-ectodomain-shedding
#16
Daniel Michael Waldera-Lupa, Omid Etemad-Parishanzadeh, Mareike Brocksieper, Nina Kirchgaessler, Sabine Seidel, Thomas Kowalski, Manuel Montesinos-Rongen, Martina Deckert, Uwe Schlegel, Kai Stühler
Primary central nervous system lymphomas (PCNSLs) are mature B-cell lymphomas confined to the central nervous system (CNS). Blood-brain barrier (BBB) dysfunction drastically alters the cerebrospinal fluid (CSF) proteome in PCNSL patients. To reveal the interaction of PCNSL tumors with CNS structures and the vasculature, we conducted a whole-proteome analysis of CSF from PCNSL patients (n = 17 at initial diagnosis) and tumor-free controls (n = 10) using label-free quantitative mass spectrometry. We identified 601 proteins in the CSF proteome using a one-step approach without further prefractionation, and quantified 438 proteins in detail using the Hi-N method...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29289110/coupled-finite-element-boundary-element-formulation-for-scattering-from-axially-symmetric-objects-in-three-dimensions
#17
Ahmad T Abawi, Petr Krysl
The fluid-structure interaction technique provides a paradigm for solving scattering from elastic structures embedded in an environment characterized by a Green's function, by a combination of finite and boundary element methods. In this technique, the finite element method is used to discretize the equations of motion for the structure and the Helmholtz-Kirchhoff integral with the appropriate Green's function is used to produce the discrete pressure field in the exterior medium. The two systems of equations are coupled at the surface of the structure by imposing the continuity of pressure and normal particle velocity...
December 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29288709/collision-of-the-glass-shards-with-the-eye-a-computational-fluid-structure-interaction-model
#18
Alireza Karimi, Reza Razaghi, Hasan Biglari, Toshihiro Sera, Susumu Kudo
The main stream of blunt trauma injuries has been reported to be related to the automobile crashes, sporting activities, and military operations. Glass shards, which can be induced due to car accident, earthquake, gunshot, etc., might collide with the eye and trigger substantial scarring and, consequently, permanently affect the vision. The complications as a result of the collision with the eye and its following injuries on each component of the eye are difficult to be diagnosed. The objective of this study was to employ a Three-Dimensional (3D) computational Fluid-Structure Interaction (FSI) model of the human eye to assess the results of the glass shards collision with the eye...
December 27, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29285989/synthesis-and-functionalization-of-chitosan-built-hydrogel-with-induced-hydrophilicity-for-extended-release-of-sparingly-soluble-drugs
#19
Faheem Ullah, Fatima Javed, Mbh Othman, Abbas Khan, Rukhsana Gul, Zulkifli Ahmad, Hazizan Md Akil
Addressing the functional biomaterials as next-generation therapeutics, chitosan and alginic acid were copolymerized in the form of chemically crosslinked interpenetrating networks (IPNs). The native hydrogel was functionalized via carbodiimide (EDC), catalyzed coupling of soft ligand (1,2-Ethylenediamine) and hard ligand (4-aminophenol) to replace -OH groups in alginic acid units for extended hydrogel- interfaces with the aqueous and sparingly soluble drug solutions. The chemical structure, Lower solution critical temperature (LCST ≈ 37...
December 29, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29285343/non-invasive-assessment-of-patient-specific-aortic-haemodynamics-from-four-dimensional-flow-mri-data
#20
Lucian Itu, Dominik Neumann, Viorel Mihalef, Felix Meister, Martin Kramer, Mehmet Gulsun, Marcus Kelm, Titus Kühne, Puneet Sharma
We introduce a parameter estimation framework for automatically and robustly personalizing aortic haemodynamic computations from four-dimensional magnetic resonance imaging data. The framework is based on a reduced-order multiscale fluid-structure interaction blood flow model, and on two calibration procedures. First, Windkessel parameters of the outlet boundary conditions are personalized by solving a system of nonlinear equations. Second, the regional mechanical wall properties of the aorta are personalized by employing a nonlinear least-squares minimization method...
February 6, 2018: Interface Focus
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