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carotid body tumor

Kalpana Kumari, Deepali Jain, Rohit Kumar, Anant Mohan, Rakesh Kumar
Paragangliomas are tumors that originate from the extra-adrenal chromaffin and nonchromaffin cells of neural crest origin. Lymph node metastases are common, while distant metastases to lung, liver, and bone are rare events and usually occur in the presence of a long standing clinically evident primary tumor. Primary diagnosis of paraganglioma at a metastatic site without a known primary is a diagnostic challenge. We report a case of an adult woman with incidentally detected metastasis to bilateral lungs from an occult carotid body paraganglioma, which presented a cytopathological diagnostic dilemma on EBUS-TBNA from paratracheal lymph nodes...
November 30, 2016: Diagnostic Cytopathology
Victor J Davila, James M Chang, William M Stone, Richard J Fowl, Thomas C Bower, Michael L Hinni, Samuel R Money
BACKGROUND: Carotid body tumors (CBTs) are rare. Management guidelines may include genetic testing for succinate dehydrogenase (SDH) mutations. We performed an institutional review of the surgical management of CBT. METHODS: A retrospective analysis (1994-2015) of CBT excisions at our institution was performed. Data obtained included demographics, genetic testing (if performed), intraoperative details, postoperative morbidity, and long-term outcomes. Data from the first CBT excision were included in patients with bilateral tumors...
December 2016: Journal of Vascular Surgery
Ilona Michałowska, Anna Lewczuk, Jarosław Ćwikła, Aleksander Prejbisz, Urszula Swoboda-Rydz, Mariusz I Furmanek, Małgorzata Szperl, Andrzej Januszewicz, Mariola Pęczkowska
BACKGROUND: Hereditary head and neck paragangliomas (HNP) are very often associated with pheochromocytoma-paraganglioma syndromes, which are caused by mutations in genes encoding subunits of succinate dehydrogenase (SDHx) complex. The aim of this study was to determine the frequency and location of HNP among SDHx carriers. MATERIAL/METHODS: A total of 72 patients with SDHx mutations underwent computed tomography examinations of the head and neck. HNP were present in 44 (61...
2016: Polish Journal of Radiology
I I Venara-Vulpe, B Morisod, G B Morand, J-B Zerlauth, C Simon
Paragangliomas are highly vascularized usually benign neoplasms originating from the sympathoadrenal and parasympathetic paraganglia of the autonomic nervous system. When resectable, the management of these tumors consists of surgical ablation preceded by transarterial embolization. The aim of this article is to describe a novel treatment strategy combining intralesional percutaneous embolization with dissection using ultrasound scissors. The case of a 74-year-old women presenting with a Shamblin type III carotid body paraganglioma is presented...
December 2016: HNO
Dragoş Cătălin Jianu, Silviana Nina Jianu, Andrei Gheorghe Marius Motoc, Traian Flavius Dan, Mărioara Poenaru, Sorina Tăban, Octavian Marius CreŢu
Carotid body paragangliomas (CBPGLs) are a rare neoplasms of the neuroendocrine system that affect the carotid glomus. The aim of this study is to improve their management in our Departments. This retrospective analysis reports family history, clinical presentation, imaging diagnostics, Shamblin classification, surgical treatment, complications, and the outcome of seven patients with CBPGLs. All lesions were represented by a painless cervical mass, with no functional or bilateral neck tumors. One patient had two different localizations (the second one was a glomus tumor of the right prelachrymal sac), and a family history for CBPGL...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Vahit Mutlu, Hayri Ogul
Carotid body tumors originate from paraganglionic tissue in the bifurcation of the common carotid artery. Magnetic resonance imaging is a frequently used diagnostic method in the preoperative diagnosis of these tumors and provides appropriate information for surgical planning. In this study, the authors emphasize magnetic resonance imaging and magnetic resonance angiography findings of the external carotid artery aneurysm associated with carotid body tumor. This highlights that the diagnosis of carotid artery aneurysms is essential to avoid accidental injury to the vessel during tumor surgery...
October 14, 2016: Journal of Craniofacial Surgery
Kenneth Hu, Mark S Persky
BACKGROUND: Commonly occurring in the head and neck, paragangliomas are typically benign, highly vascular neoplasms embryologically originating from the extra-adrenal paraganglia of the neural crest. Frequently, these tumors are associated with the vagus or tympanic plexus nerve or the carotid artery, or jugular bulb. Their clinical presentation can vary across a wide spectrum of signs and symptoms. METHODS: We reviewed and compared standard treatment approaches for paragangliomas of the head and neck...
July 2016: Cancer Control: Journal of the Moffitt Cancer Center
Attje S Hoekstra, Ruben D Addie, Cor Ras, Reza M Seifar, Claudia A Ruivenkamp, Inge H Briaire-de Bruijn, Frederik J Hes, Jeroen C Jansen, Eleonora P M Corssmit, Willem E Corver, Hans Morreau, Judith V M G Bovée, Jean-Pierre Bayley, Peter Devilee
Mutations in SDHD and SDHAF2 (both located on chromosome 11) give rise to hereditary paraganglioma almost exclusively after paternal transmission of the mutation, and tumours often show loss of the entire maternal copy of chromosome 11. The 'Hensen' model postulates that a tumour modifier gene located on chromosome 11p15, a region known to harbour a cluster of imprinted genes, is essential to tumour formation. We observed decreased protein expression of the 11p15 candidate genes CDKN1C, SLC22A18 and ZNF215 evaluated in 60 SDHD-mutated tumours compared to normal carotid body tissue and non-SDH mutant tumours...
July 8, 2016: Human Molecular Genetics
Y Law, Y C Chan, S W Cheng
BACKGROUND: The study aims to conduct a review of the surgical management of carotid body tumor. METHODS: Consecutive patients with CBT who received surgical interventions from January 1994 to January 2014 at our institution were reviewed. Clinical, operative, pathological and follow up information were reported. RESULTS: Twenty patients (four males; median age was 36) with 21 CBT operations were recorded during the period. One patient undertook sequential operations for bilateral CBTs...
June 29, 2016: Vascular
G Psychogios, A Berlis, B Märkl, T Schaller, M N Psychogios, J Zenk
Introduction: Paragangliomas are rare tumors representing a therapeutic challenge. In particular, the surgical removal may lead to life-threatening bleeding. The preoperative percutaneous embolization is an alternative that allows a high closure rate of tumor-feeding vessels in a short intervention time and thus significantly reduces intraoperative bleeding probability. Complete tumor resection is facilitated thereby. The use of a new non-adhesive liquid embolic agent is presented here. Methods: A 50-year old patient presented with 4 cm large paraganglioma of the carotid body (Shamblin II)...
June 29, 2016: Laryngo- Rhino- Otologie
Zhan-Qiang Jin, Wen He, Dong-Fang Wu, Mei-Ying Lin, Hua-Tang Jiang
A carotid body tumor (CBT) is a rare, non-chromaffin paraganglioma, and its diagnosis mainly depends on imaging modalities. The aim of this study was to investigate the ability of color Doppler ultrasound (CDU) in the diagnosis and assessment of CBT based on computed tomography (CT). We retrospectively reviewed the CDU and CT features of 49 consecutive CBTs and 23 schwannomas from 67 patients and compared these findings with surgical resection specimens. The mean size of CBT lesions on ultrasound scans and CT angiography (CTA) was 3...
September 2016: Ultrasound in Medicine & Biology
Sureshkannan Prabakaran, Anand Shankar Subburayulu, P T Ravikumar
Paragangliomas arising from the carotid body in the carotid bifurcation are termed as carotid body tumors. They are usually slow growing and asymptomatic. Considering the anatomical location, invasion or pressure on the adjacent vascular and neural tissues, the importance of early diagnosis and management is critical. In this article a case of carotid body tumor excised through transverse neck skin crease incision is presented along with literature review on the diagnosis, grading and different surgical approaches...
June 2016: Journal of Maxillofacial and Oral Surgery
E Lamblin, I Atallah, E Reyt, S Schmerber, J-L Magne, C A Righini
OBJECTIVE: The present consecutive case series reports our experience in the management of carotid body paraganglioma and aims to assess whether the Shamblin classification or tumor size are predictive of early and late postoperative neurovascular complications. MATERIAL AND METHODS: A retrospective study included 54 carotid body tumor resections in 49 patients, between 1980 and 2011. Data comprised early (<1month) and late (18 months) postoperative neurovascular complications...
June 10, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
Moustafa Mourad, Masoud Saman, David Stroman, Ryan Brown, Yadranko Ducic
OBJECTIVES/HYPOTHESIS: To review the surgical management of carotid body tumors (CBT), outcomes of carotid artery reconstruction, as well as utility of preoperative embolization. STUDY DESIGN: Retrospective chart review. METHODS: A single-surgeon case series with chart review was performed of all cases between 1997 and 2014 at a single institution. Tumor classification, major neurovascular resection, requirement for in-line carotid artery reconstruction, intraoperative blood loss, and operative time, and postoperative neurovascular complications were determined...
October 2016: Laryngoscope
Cecelia E Schmalbach, Christine Gourin
The most common vascular tumors encountered by the otolaryngologist are rare chromaffin cell tumors termed paragangliomas. Within the head and neck region, they commonly arise from the carotid body, vagus nerve (glomus vagale), and jugular vein (glomus jugulare). Other vascular head and neck tumors include sinonasal malignancies, because of proximity to or involvement of the pterygoid plexus as well as the rich vascularity of the sinonasal mucosa; juvenile nasopharyngeal angiofibroma, a vascular tumor of male adolescents; unusual vascular tumors such as hemangiopericytoma; and metastatic renal cell cancer, which has a proclivity for an unusually rich blood supply...
June 2016: Otolaryngologic Clinics of North America
Davin Yavapolkul, Tatsanachat Jittreetat
This is a case report of synchronous bilateral carotid body tumor, bilateral jugulotympanic and left subclavian paraganglioma in a 38-year-old man who presented with a history of slow-growing bilateral neck masses for 4 years and a one-month history of right facial palsy, tinnitus, and hearing loss. A discussion of this case is followed by a review of the literature surrounding this rare clinical entity.
February 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Kuo-Wei Wang, Hao-Kuang Wang, Kang Lu, Cheng-Loong Liang, Ya-Wen Chen, Po-Chou Liliang
BACKGROUND: C2 vertebroplasty is more challenging than transpedicular percutaneous vertebroplasty in the thoracic and lumbar spine. OBJECTIVE: We report an anterior ascending approach for C2 percutaneous vertebroplasty to avoid potential injury to vital structures surrounding the C2 vertebra. STUDY DESIGN: A technique note with 5 consecutive cases. SETTING: Neurosurgery department of a university hospital. METHODS: Fluoroscopically guided manual compression was applied using 3 fingers at the C5 level between the muscle and trachea...
May 2016: Pain Physician
Jose Ignacio Torrealba, Francisco Valdés, Albrecht H Krämer, Renato Mertens, Michel Bergoeing, Leopoldo Mariné
BACKGROUND: The carotid bifurcation can host a variety of tumors requiring complex surgical management. Treatment requires resection and, in some cases, vascular reconstruction that may compromise the cerebral circulation. The most frequent lesion at this location is the carotid body tumor (CBT). CBT are classified according to Shamblin in 3 types depending on the degree of carotid vessels encasement. Our main objective was to report our clinical experience managing carotid bifurcation tumors throughout the last 30 years...
July 2016: Annals of Vascular Surgery
Tsutomu Hirano, Satoko Yamashita, Masaki Takahashi, Hiroyuki Hashimoto, Yusaku Mori, Moritaka Goto
INTRODUCTION: Several studies have demonstrated suppression of aortic atherosclerosis by dipeptidyl peptidase-4 (DPP-4) inhibitors in hypercholesterolemic mice. However, it remains unknown whether DPP-4 inhibitors also exert anti-atherogenic effects in coronary arteries. We examined the effect of anagliptin, a DPP-4 inhibitor, on atherosclerosis development in the aorta and coronary arteries in a high-cholesterol diet-fed rabbits. METHODS: Japanese white rabbits were fed either normal chow (n=8) or a diet containing 0...
June 2016: Metabolism: Clinical and Experimental
SreyRam Kuy
A 46-year-old woman noted a right-sided neck lump one year ago. A CT scan demonstrated a right-sided 2 cm mass located between the external and internal carotid arteries that enhanced with contrast and caused splaying of the carotid bifurcation, suggesting a carotid body tumor (Figure A). She had no neurological symptoms. She underwent surgical excision of the mass, without trauma to the carotid vessels and care was taken to identify the Hypoglossal and vagus nerves. Intraoperatively, the mass was found to be supplied by several small vessels from the external carotid artery but without any attachment to the arterial walls (Figure B), consistent with a Shamblin Class 1 carotid body tumor...
July 2015: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
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