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carotid body tumor

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https://www.readbyqxmd.com/read/29600100/unusual-cardiac-paraganglioma-mimicking-an-atypical-carcinoid-tumor-of-the-lung
#1
Dean Spencer, Mark Evans, Beverly Wang, J Lawrence Delrosario, Timmy Cheng, Jeffrey Milliken
We present a case of unusual cardiac paraganglioma (PG) initially misdiagnosed as atypical carcinoid tumor of the lung and discuss key clinical and pathologic characteristics that guide surgical management of these rare chromaffin cell tumors. A 64-year-old female with persistent cough and back pain was found to have a 4 cm × 3 cm mass abutting multiple cardiopulmonary structures. A biopsy was performed at an outside institution and pathology reported "atypical neuroendocrine carcinoma, consistent with carcinoid"...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29552173/multi-institutional-survey-of-carotid-body-tumors-in-japan
#2
Aya Ikeda, Kiyoto Shiga, Katsunori Katagiri, Daisuke Saito, Jun Miyaguchi, Shin-Ichi Oikawa, Kodai Tsuchida, Takahiro Asakage, Hiroyuki Ozawa, Ken-Ichi Nibu, Naoki Ohtsuki, Yasushi Fujimoto, Ken-Ichi Kaneko
There has been no attempt to clarify the status of patients with carotid body tumor (CBT) in Japan. This multi-institutional survey analyzed patients with CBT throughout Japan by gathering information on these patients from institutions that performed head and neck surgeries. Information from a total of 150 patients from 25 institutions from the past 20 years was employed in the present survey. There were 87 females and 63 males, and their mean age was 48.0 years old. The most common chief complaint was a neck mass and the mean suffering period was 46...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29531527/different-associations-of-trunk-and-lower-body-fat-mass-distribution-with-cardiometabolic-risk-factors-between-healthy-middle-aged-men-and-women
#3
Bin Wu, Jingshan Huang, Keisuke Fukuo, Kazuhisa Suzuki, Gen Yoshino, Tsutomu Kazumi
The aim of this study was to assess whether the gender-specific pattern of fat mass (FM) distribution is related to gender differences in cardiometabolic risk factors. 207 healthy middle-aged Japanese were included in the study. We measured FM in the total body, trunk, and lower-body with dual-energy X-ray absorptiometry (DXA). The percentage of trunk FM (TFM) and lower-body FM (LFM) is noted as %TFM and %LFM, respectively. Other measurements included glucose and insulin during oral glucose tolerance test (OGTT), leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor- α (TNF- α ), C-reactive protein (CRP), and systemic oxidative stress marker...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29504908/exome-analysis-of-carotid-body-tumor
#4
Anastasiya V Snezhkina, Elena N Lukyanova, Dmitry V Kalinin, Anatoly V Pokrovsky, Alexey A Dmitriev, Nadezhda V Koroban, Elena A Pudova, Maria S Fedorova, Nadezhda N Volchenko, Oleg A Stepanov, Ekaterina A Zhevelyuk, Sergey L Kharitonov, Anastasiya V Lipatova, Ivan S Abramov, Alexander V Golovyuk, Yegor E Yegorov, Khava S Vishnyakova, Alexey A Moskalev, George S Krasnov, Nataliya V Melnikova, Dmitry S Shcherbo, Marina V Kiseleva, Andrey D Kaprin, Boris Y Alekseev, Andrew R Zaretsky, Anna V Kudryavtseva
BACKGROUND: Carotid body tumor (CBT) is a form of head and neck paragangliomas (HNPGLs) arising at the bifurcation of carotid arteries. Paragangliomas are commonly associated with germline and somatic mutations involving at least one of more than thirty causative genes. However, the specific functionality of a number of these genes involved in the formation of paragangliomas has not yet been fully investigated. METHODS: Exome library preparation was carried out using Nextera® Rapid Capture Exome Kit (Illumina, USA)...
February 13, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/29495959/successful-resection-of-a-large-carotid-body-tumor-masquerading-complete-encasement-of-the-internal-carotid-artery-on-preoperative-imaging
#5
Stavros K Kakkos, Peter Zampakis, George C Lampropoulos, Leonidas Paridis, Charalampos Kaplanis, Dimitra Bantouna, Konstantinos M Nikolakopoulos, Chrysanthi P Papageorgopoulou, Christina Kalogeropoulou, Ioannis A Tsolakis
A 41-year-old woman presented with a large painful and tender mass of the left side of her neck located just below the angle of the mandible. She was also complaining of frequent attacks of symptoms ranging from dizziness upon resuming the erect position to frank syncope. Color-coded duplex showed a large well-vascularized vascular mass at the level of the carotid bifurcation, suggesting the diagnosis of a carotid body tumor (CBT). A computerized tomographic angiography confirmed the diagnosis of a CBT, which measured 5...
January 1, 2018: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29398127/carotid-dosimetry-and-the-risk-of-carotid-blowout-syndrome-after-reirradiation-with-head-and-neck-stereotactic-body-radiation-therapy
#6
Brian J Gebhardt, John A Vargo, Diane Ling, Brianna Jones, Mary Mohney, David A Clump, James P Ohr, Robert L Ferris, Dwight E Heron
PURPOSE: To correlate carotid dose and risk of carotid blowout syndrome (CBOS) after stereotactic body radiation therapy (SBRT), hypothesizing that carotid dose does not correlate with CBOS. METHODS AND MATERIALS: We retrospectively reviewed 186 patients with recurrent, previously irradiated head and neck cancer treated between January 2008 and March 2013. Patients treated early in our experience with incomplete dosimetry were excluded from analysis (n = 111). A total of 75 patients were identified, providing 150 carotid arteries for analysis...
December 5, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29375704/diagnosis-and-treatment-of-a-carotid-body-tumor-a-case-report-of-a-rare-bilateral-tumor
#7
Qiang Sun, Chenlu Xie, Zhixing Niu, Lei Su, Xi Wang, Zheng Fang, Junfang Zhao, Shuai Chen, Xinming Li, Minglei Sun
In the present case report, a rare bilateral carotid body tumor (CBT) and the imaging and pathological features of a CBT are described. In the present report, a rare case of bilateral carotid body tumor, which developed in the bifurcation of the common carotid artery, and the clinical manifestations, imaging and pathological features of this CBT are summarized. The imaging cannot validate the diagnosis; however, imaging identified that the tumor exhibited an intact envelope. Immunohistochemical staining revealed that the tumor cells were strongly positive for cluster of differentiation 56, Syn and protein S-100, moderately positive for transcription factor E3, negative for cytokeratin and epithelial membrane antigen, and partial cells were weakly positive for Desmir (<5%)...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29372869/vmat-stereotactic-body-radiation-therapy-in-a-multimodal-approach-to-a-carotid-paraganglioma-in-a-dog
#8
Mario Dolera, Nancy Carrara, Luca Malfassi
A 7 yr old female pit bull terrier was presented for a cervical soft tissue swelling located in the left jugular region. No abnormalities were present at physical examination or in the laboratory workup. Computed tomography and MRI scans showed a well-defined, ovoid, single mass in the left dorsal cervical region connected to the common carotid artery, histologically consistent with carotid body paraganglioma. The mass was surgically resected. Frameless stereotactic body radiation therapy with volumetric modulated arc therapy was set up as adjuvant treatment...
March 2018: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/29320547/dyslipidemia-chronic-inflammation-and-subclinical-atherosclerosis-in-children-and-adolescents-infected-with-hiv-the-posithive-health-study
#9
Luiz Rodrigo Augustemak de Lima, Edio Luiz Petroski, Yara Maria Franco Moreno, Diego Augusto Santos Silva, Erasmo Benício de Moraes Santos Trindade, Aroldo Prohmann de Carvalho, Isabela de Carlos Back
HIV-infected children and adolescents may be at risk for cardiovascular disease due to chronic inflammation and exacerbation of risk factors. The aim of this study was as follows: 1) compare cardiovascular risk factors, chronic inflammation, and carotid intima-media thickness (IMTc) between the HIV and control groups; 2) determine the association of HIV and antiretroviral (ART) regimens with cardiovascular risk factors, chronic inflammation, and IMTc; and 3) identify variables associated with elevated IMTc...
2018: PloS One
https://www.readbyqxmd.com/read/29259765/case-report-managing-a-giant-high-grade-carotid-body-tumor-in-a-resource-limited-setting
#10
Sunil Munakomi, Samrita Chaudhary, Iype Cherian
Herein we report the management of a giant, high-grade and vascular carotid body tumor in a young woman. She presented with slowly progressive neck swelling. Vascular imaging revealed a left-sided, high-grade giant carotid body tumor (> 8cm).  The tumor was completely excised by caudocranial subadventitial dissection. Histology of the tumor revealed a characteristic Zellballen pattern of the lesion, suggestive of a paraganglioma. The patient made an uneventful recovery. We also discuss newer insights regarding the management of such highly vascular lesions...
2017: F1000Research
https://www.readbyqxmd.com/read/29147633/a-unique-case-of-carotid-splaying-by-a-cervical-vagal-neurofibroma-and-the-role-of-neuroradiology-in-surgical-management
#11
Sally A Itawi, Mark Buehler, Robert E Mrak, Tarek R Mansour, Yacine Medhkour, Azedine Medhkour
Carotid splaying, also known as the Lyre sign, is a widening of the carotid bifurcation due to the displacement of the internal carotid artery and the external carotid artery just distal to the point of divergence. This phenomenon is classically exhibited by highly vascularized carotid body tumors and, in rare cases, by cervical sympathetic chain schwannomas. Demonstration of the Lyre sign by a cervical vagal neurofibroma, however, is a unique occurrence that has not been previously documented in the literature...
September 7, 2017: Curēus
https://www.readbyqxmd.com/read/29147595/synchronous-ganglioneuroma-and-schwannoma-mistaken-for-carotid-body-tumor
#12
Konstantinos Paraskevopoulos, Angeliki Cheva, Styliani Papaemmanuil, Konstantinos Vahtsevanos, Konstantinos Antoniades
Ganglioneuromas are a very rare benign neural tumor, commonly derived from the ganglia of the sympathetic system, and are composed of mature Schwann cells, ganglion cells, and nerve fibres. They may arise anywhere from the base of the skull to the pelvis along the paravertebral sympathetic plexus. We report a rare case of synchronous ganglioneuroma and schwannoma, mistaken for carotid body tumor. The coexistence of these two entities in head and neck region is very rare.
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29134169/age-and-tumor-volume-predict-growth-of-carotid-and-vagal-body-paragangliomas
#13
Berdine L Heesterman, Lisa M H de Pont, Berit M Verbist, Andel G L van der Mey, Eleonora P M Corssmit, Frederik J Hes, Peter Paul G van Benthem, Jeroen C Jansen
Objective  Treatment for head and neck paragangliomas (HNGPL) can be more harmful than the disease. After diagnosis, an initial period of surveillance is often indicated, and surgery or radiotherapy is reserved for progressive disease. With the aim to optimize this "wait and scan" strategy, we studied growth and possible predictors. Design  A retrospective cohort study was conducted. Setting  This study was conducted at a tertiary referral center for patients with HNGPL. Methods  Tumor volume was estimated for 184 SDHD -related carotid and vagal body paragangliomas using sequential magnetic resonance imaging...
December 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29070503/aerobic-exercise-training-induced-changes-in-serum-c1q-tnf-related-protein-levels-are-associated-with-reduced-arterial-stiffness-in-middle-aged-and-older-adults
#14
Natsuki Hasegawa, Shumpei Fujie, Naoki Horii, Masataka Uchida, Toshiyuki Kurihara, Kiyoshi Sanada, Takafumi Hamaoka, Motoyuki Iemitsu
Adiponectin regulates endothelial nitric oxide synthase in endothelial cells, and body fat loss by aerobic exercise training promotes adiponectin secretion. Recently, C1q/tumor necrosis factor-related proteins (CTRPs) have been identified as novel adipokines and are paralogs of adiponectin, but the association between exercise training-induced reduction of arterial stiffness and circulating CTRPs levels remains unclear. This study aimed to clarify whether the reduction of arterial stiffness in middle-aged and older adults is associated with the change in serum levels of CTRPs induced by exercise training...
January 1, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28990108/the-effect-of-anagliptin-on-intimal-hyperplasia-of-rat-carotid-artery-after-balloon-injury
#15
Qi Li, Xiayang Wu, Yanli Liu, Mingyu Zhang, Xue Bai, Chang Chen
The present study evaluated the effect of anagliptin on intimal hyperplasia following carotid artery injury in Sprague‑Dawley rats. Sprague‑Dawley rats weighing 280‑300 g were injured using a 2F Fogarty balloon embolectomy catheter. The rats were divided into injury‑(saline) and anagliptin‑(10 mg/kg/day) treated groups. vascular injuries were induced in the left carotid artery, followed by evaluation of neointima formation at 28 days. The right and left carotid arteries were harvested and evaluated with histological evaluation, and the plasma activity of glucagon‑like peptide 1 receptor (GLP‑1), stromal cell‑derived factor (SDF)‑1α, interleukin (IL)‑6, IL‑1β and tumor necrosis factor (TNF)‑α were detected by ELISA analysis...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28977582/cardiac-paraganglioma-with-a-novel-germline-mutation-of-succinate-dehydrogenase-gene-d
#16
Naoyuki Otani, Kokichi Sugano, Shu Inami, Hirohisa Amano, Takuo Arikawa, Shinya Saito, Kazuho Imai, Mineko Ushiama, Teruhiko Yoshida, Noriko Kimura, Shigeru Toyoda, Teruo Inoue
A 58-year-old woman with a past medical history of a carotid body tumor, resected 4 months prior to presentation, was admitted to our hospital for treatment of a cardiac tumor that was identified on post-operative echocardiography and chest computed tomography. The cardiac tumor was surgically removed and identified pathologically as a paraganglioma, similarly to the carotid body tumor. Genetic analysis of both tumors identified a non-synonymous mutation in the succinate dehydrogenase (SDH) gene D, Exon4, c...
December 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28944913/oleanolic-acid-alleviates-diabetic-rat-carotid-artery-injury-through-the-inhibition-of-nlrp3-inflammasome-signaling-pathways
#17
Qian An, Qian Hu, Bing Wang, Wenjun Cui, Fei Wu, Yu Ding
The overexpression of inflammasome components is correlated with diabetes‑associated complications. Oleanolic acid is a triterpenoid compound which is important in arterial injury. The present study evaluated whether oleanolic acid improved diabetic rat carotid artery injury through the inhibition of nucleotide‑binding domain, leucine‑rich‑containing family, pyrin domain‑containing‑3 (NLRP3) inflammasomes signaling pathways. A diabetic rat model was induced using streptozotocin (60 mg/kg) and underwent carotid artery injury...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28931297/-intracranial-pressure-evaluation-by-ophthalmologist
#18
J Čmelo, R Illéš, J Šteňo
The value of ICT is important in diagnosis of the diseases of the eye and orbit Methods for direct measurement of intracranial pressure (ICT) are exact, but they are invasive and there is some risk of infection and damage of the tissue. Currently there are 2 valid indirect methods of mesurement of IKT. Digital Ophthalmodynamometry (D-ODM) and Transcranial Doppler ultrasonography (TDU). D-ODM is a non-invasive method for measuring of the Pulsating Venous Pressure (VPT). We can measure VPT by the pulse phenomena...
2017: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/28927123/diagnosis-and-surgical-treatment-of-carotid-body-tumor-a-retrospective-analysis-of-58-patients
#19
Qingquan Hua, Zhen Xu, Yang Jiang
The aim of the present study was to illustrate the diagnosis and treatment of carotid body tumor (CBT) based on our experience of previous patients. A total of 58 patients (62 lesions) with CBT who received surgery between October 2003 and October 2013 were included. In total, 17 lesions were categorized into Shamblin grade I, 33 were grade II, and 12 were grade III. Surgical resection of CBT was performed for 52 lesions, resection of CBT and the external carotid artery was performed for 9 lesions, and resection of CBT and the internal carotid artery was performed for 1 lesion...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28872499/mean-platelet-volume-red-cell-distribution-width-and-neutrophil-to-lymphocyte-ratio-before-and-after-surgery-in-patients-with-carotid-body-tumors
#20
Nazim Bozan, Ömer Faruk Kocak, Mehmet Emre Dinc, Canser Yilmaz Demir, Mahfuz Turan, Ahmet Faruk Kiroglu
OBJECTIVE: Carotid body tumors (CBTs) are rare hypervascular benign tumors that originate from the paraganglia at the carotid bifurcation. The red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and mean platelet volume (MPV) may serve as markers in inflammatory, cardiovascular, and neoplastic diseases. However, their prognostic value in CBTs is unknown. The purpose of this study was to assess the leukocyte count, MPV, RDW, and NLR before and after surgery in patients with CBTs...
October 2017: Journal of Craniofacial Surgery
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