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chronic limb ischemia

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https://www.readbyqxmd.com/read/29889530/immunopet-of-cd146-in-a-murine-hindlimb-ischemia-model
#1
Carolina A Ferreira, Reinier Hernandez, Yunan Yang, Hector F Valdovinos, Jonathan W Engle, Weibo Cai
Peripheral Arterial Disease (PAD) is a chronic occlusion of lower-extremity arteries distal to the aortic bifurcation attributable to atherosclerosis. PAD is associated with an elevated risk of morbidity and mortality as well as of deterioration of the quality of life with claudication and chronic leg ischemia being the most frequent complications. Therapeutic angiogenesis is a promising therapeutic strategy that aims to restore the blood flow to the ischemic limb. In this context, assessing the efficacy of pro-angiogenic treatment using a reliable non-invasive imaging technique would greatly benefit the implementation of this therapeutic approach...
June 11, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29885428/the-impact-of-perioperative-ankle-brachial-index-and-clinical-status-on-outcomes-following-lower-extremity-bypass
#2
Thomas F X O'Donnell, Sarah E Deery, Marc L Schermerhorn, Jeffrey J Siracuse, Daniel J Bertges, Alik Farber, Robert T Lancaster, Virendra I Patel
OBJECTIVE: Ankle-brachial index (ABI) is a common method of graft surveillance after infrainguinal bypass surgery (LEB), and is recommended by the Society for Vascular Surgery (SVS). Several studies failed to show benefit of ABI surveillance, but were limited by sample size, and the practice remains variable. METHODS: We identified all patients who underwent LEB for occlusive disease from the Vascular Study Group of New England Registry (VSGNE) between 2003-2016...
June 6, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29850143/total-arch-replacement-and-frozen-elephant-trunk-for-type-a-aortic-dissection-after-bentall-procedure-in-marfan-syndrome
#3
Yu Chen, Wei-Guo Ma, Jun Zheng, Yong-Min Liu, Jun-Ming Zhu, Li-Zhong Sun
Background: We seek to report the long-term outcomes of the total arch replacement and frozen elephant trunk (TAR + FET) technique for type A aortic dissection (TAAD) following prior Bentall procedure in patients with Marfan syndrome (MFS). Methods: Between 2003 and 2015, we performed TAR + FET for 26 patients with MFS who developed TAAD following a prior Bentall procedure. Mean age at FET 36.9±9.7 years and 24 were males. TAAD was acute in 8 (30.8%, all new dissections from precious root aneurysm) and chronic in 18 (69...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29804736/a-systematic-review-and-meta-analysis-of-revascularization-outcomes-of-infrainguinal-chronic-limb-threatening-ischemia
#4
Jehad Almasri, Jayanth Adusumalli, Noor Asi, Sumaya Lakis, Mouaz Alsawas, Larry J Prokop, Andrew Bradbury, Philippe Kolh, Michael S Conte, M Hassan Murad
BACKGROUND: The optimal strategy for revascularization in infrainguinal chronic limb-threatening ischemia (CLTI) remains debatable. Comparative trials are scarce, and daily decisions are often made using anecdotal or low-quality evidence. METHOD: We searched multiple databases through May 7, 2017, for prospective studies with at least 1-year follow-up that evaluated patient-relevant outcomes of infrainguinal revascularization procedures in adults with CLTI. Independent pairs of reviewers selected articles and extracted data...
May 24, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29802042/prognostic-value-of-the-society-for-vascular-surgery-wound-ischemia-and-foot-infection-wifi-classification-in-patients-with-no-option-chronic-limb-threatening-ischemia
#5
Steven T W van Haelst, Martin Teraa, Frans L Moll, Gert J de Borst, Marianne C Verhaar, Michael S Conte
OBJECTIVE: The Wound, Ischemia, and foot Infection (WIfI) classification was developed to assess amputation risk and hence to aid in clinical decision-making in patients with chronic limb-threatening ischemia (CLTI). WIfI has been validated in multiple CLTI cohorts worldwide. In this study, we examined the relationship between WIfI stage and clinical outcomes in a well-defined subpopulation of CLTI patients considered not eligible for conventional revascularization. The aim of this study was to assess the prognostic value of the WIfI classification for clinical outcomes in a "no-option" CLTI population...
May 22, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29798772/1-year-all-comers-analysis-of-the-eluvia-drug-eluting-stent-for-long-femoropopliteal-lesions-after-suboptimal-angioplasty
#6
Theodosios Bisdas, Efthymios Beropoulis, Angeliki Argyriou, Giovanni Torsello, Konstantinos Stavroulakis
OBJECTIVES: The aim of this study was to assess the performance of the fluoropolymer-based paclitaxel-eluting stent (PES) in long femoropopliteal lesions. BACKGROUND: The new-generation fluoropolymer-based PES showed promising outcomes in short femoropopliteal lesions. The main feature of the stent is its controlled and sustained paclitaxel release over 12 months. However, the safety and efficacy of this technology in longer femoropopliteal lesions remain unclear...
May 28, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29792553/mitochondrial-complex-i-defect-resulting-from-exercise-induced-lower-limb-ischemia-in-patients-with-peripheral-arterial-disease
#7
Isabelle Signolet, Pierre Abraham, Stéphanie Chupin, Myriam Ammi, Naïg Gueguen, Franck Letournel, Jean Picquet, Christophe Baufreton, Mickael Daligault, Vincent Procaccio, Pascal Reynier, Samir Henni
OBJECTIVE: This study aims to compare the structural and mitochondrial alterations between muscle segments affected by exercise-induced ischemia and segments of the same muscle without ischemia, in the same subject. METHODS: In a prospective analysis, 34 patients presenting either peripheral arterial disease or chronic coronary syndrome without any evidence of peripheral arterial disease were eligible for inclusion based on findings indicating a need for either a femoro-popliteal bypass or a saphenous harvesting for coronary bypass...
May 24, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29790720/recanalization-of-ctos-with-soundbitetm-active-wire
#8
Marianne Brodmann, Eric Thérasse, Andrew Benko, Louis-Philippe Riel, Steven Dion, Philippe Généreux, Martin Brouillette
BACKGROUND: The aim of this study was to examine the safety and efficacy of the SoundBite™ Crossing System for the recanalization of infrainguinal chronic total occlusion (CTO) lesions. CTOs are frequent among patients with severe claudication or critical limb ischemia. Failure to recanalize CTOs remains common and is associated with poor prognosis. The SoundBite™ Crossing System (SoundBite Medical Solutions Inc., Montreal, Canada) is a newly developed device that uses a 0.018-inch wire (SoundBite™ Active Wire) to deliver acoustic shock waves to the distal tip of a steerable guidewire to facilitate directed penetration of the proximal cap and crossing of the occlusion...
May 23, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29785211/a-very-rare-cause-of-lower-limb-ischemia-in-young-people-popliteal-artery-entrapment
#9
Hasan Baki Altinsoy, Ozkan Alatas, Emjed Khalil, Kenan Abdurrahman Kara, Candan Cudi Okten, Omer Faruk Dogan
Background: Popliteal artery entrapment syndrome (PAES) is a very rare pathology that can cause lower extremity ischemia in healthy young people. Anomalous anatomic relationships between the popliteal artery (PA) and the surrounding musculo-tendinous structures cause PAES. We present 31 patients with PAES in 35 limbs that were treated surgically in our clinic within a 12-year period. Patients and Methods: From 2001 to 2015, 31 patients (mean age: 32 ± 7.4 years) underwent surgery for PAES...
2018: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/29783030/venous-conduits-have-superior-patency-compared-to-prosthetic-grafts-for-femoro-femoral-bypass
#10
Khanh Nguyen, Gregory Moneta, Gregory Landry
OBJECTIVE: To compare outcomes of externally supported polytetrafluoroethylene (PTFE) grafts and femoral vein as conduits for femoro-femoral crossover grafts. METHODS: This is a retrospective review of consecutive femoro-femoral crossover grafts at our institution between January 2005 and March 2016. Patient demographics, indications, complication rates, patency rates and survival rates were compared between femoro-femoral grafts created with either PTFE or femoral vein conduits, autogenous or cryopreserved...
May 18, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29778609/emergency-department-utilization-after-lower-extremity-bypass-for-critical-limb-ischemia
#11
Vangelina Osteguin, Thomas W Cheng, Alik Farber, Mohammad H Eslami, Jeffrey A Kalish, Douglas W Jones, Denis Rybin, Stephen J Raulli, Jeffrey J Siracuse
OBJECTIVES: Patients with critical limb ischemia (CLI) utilize hospital resources at high rates. One major driver for resource utilization are Emergency Department (ED) visits. Our goal was to assess perioperative ED visits after lower extremity bypass (LEB) for CLI. METHODS: All patients undergoing LEB for CLI from 2008 to 2017 at our institution were analyzed. Emergency department visits and details of the visit within 30 and 90 days of discharge from index admission were recorded...
May 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29731636/critical-limb-ischemia-current-challenges-and-future-prospects
#12
REVIEW
Luigi Uccioli, Marco Meloni, Valentina Izzo, Laura Giurato, Stefano Merolla, Roberto Gandini
Critical limb ischemia (CLI) is considered the most severe pattern of peripheral artery disease. It is defined by the presence of chronic ischemic rest pain, ulceration or gangrene attributable to the occlusion of peripheral arterial vessels. It is associated with a high risk of major amputation, cardiovascular events and death. In this review, we presented a complete overview about physiopathology, diagnosis and holistic management of CLI. Revascularization is the first-line treatment, but several challenging cases are not treatable by conventional techniques...
2018: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29724818/hypoxia-and-ischemia-promote-a-maladaptive-platelet-phenotype
#13
Scott J Cameron, Doran S Mix, Sara K Ture, Rachel A Schmidt, Amy Mohan, Daphne Pariser, Michael C Stoner, Punit Shah, Lijun Chen, Hui Zhang, David J Field, Kristina L Modjeski, Sandra Toth, Craig N Morrell
OBJECTIVE: Reduced blood flow and tissue oxygen tension conditions result from thrombotic and vascular diseases such as myocardial infarction, stroke, and peripheral vascular disease. It is largely assumed that while platelet activation is increased by an acute vascular event, chronic vascular inflammation, and ischemia, the platelet activation pathways and responses are not themselves changed by the disease process. We, therefore, sought to determine whether the platelet phenotype is altered by hypoxic and ischemic conditions...
May 3, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29703251/allogeneic-transplantation-of-programmable-cells-of-monocytic-origin-pcmo-improves-angiogenesis-and-tissue-recovery-in-critical-limb-ischemia-cli-a-translational-approach
#14
Rouven Berndt, Lars Hummitzsch, Katharina Heß, Martin Albrecht, Karina Zitta, Rene Rusch, Beke Sarras, Andreas Bayer, Jochen Cremer, Fred Faendrich, Justus Groß
BACKROUND: Employing growth factor-induced partial reprogramming in vitro, peripheral human blood monocytes can acquire a state of plasticity along with expression of various markers of pluripotency. These so-called programmable cells of monocytic origin (PCMO) hold great promise in regenerative therapies. The aim of this translational study was to explore and exploit the functional properties of PCMO for allogeneic cell transplantation therapy in critical limb ischemia (CLI). METHODS: Using our previously described differentiation protocol, murine and human monocytes were differentiated into PCMO...
April 27, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29701340/comparaison-between-endovascular-approach-and-aorto-bifemoral-bypass-for-tasc-d-aorto-iliac-disease-patients-treated-between-2011-2017
#15
Joel Sousa, João Neves, André Ferreira, José Vidoedo, José Teixeira
INTRODUCTION: In the last few years, endovascular approaches have been demonstrating remarkable results on the treatment of aortoiliac TASC D lesions. However, the results remain conflictuous and proper evidence regarding the best treatment option for this group of patients is still lacking. Through this work, we aim to compare patency, cost-effectiveness and quality of life in patients successfully treated by these two approaches. METHODS: Patients with TASC D aorto-iliac disease, from two independent Vascular Surgery Centers, treated either by open surgery and endovascular intervention between 2011- 2017, were retrospectively analyzed and consecutively included (n=59)...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29697685/-ruptures-of-popliteal-artery-aneurysms
#16
I P Mikhaylov, V N Lavrenov, G A Isaev, L S Kokov, E Yu Trofimova
AIM: To improve diagnosis and surgical outcomes in patients with ruptured popliteal artery aneurysm. MATERIAL AND METHODS: Eight patients with ruptured popliteal artery aneurysm have undergone surgery for the period from 1999 to 2015 at the Vascular Surgery Department of Sklifosovsky Research Institute for Emergency Care. Incidence of rupture was 2.9% from total number of popliteal artery aneurysm. 7 patients with rupture had signs of lower limb ischemia (acute form grade I in 2 (25%) cases, grade IIA in 1 (12...
2018: Khirurgiia
https://www.readbyqxmd.com/read/29688737/endovascular-procedures-in-treatment-of-infrapopliteal-arterial-occlusive-disease-single-center-experience-with-69-infrapopliteal-procedures
#17
Pasternak J Janko, Budakov B Nebojsa, Petres V Andrej
BACKGROUND: Peripheral arterial occlusive disease (PAD) includes acute and chronic disorders of the blood supply as a result of obstruction of blood flow in the arteries of the limb. Treatment of PAD can be conservative, surgical and endovascular. Percutaneous transluminal angioplasty with or without stenting has become a recognized method, which is increasingly used in treatment of arterial occlusive disease. This study aimed to determine early results of endovascular treatment of critical limb ischemia (CLI) patients with infrapopliteal lesions...
March 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29682105/when-are-endovascular-and-open-bypass-treatments-preferred-for-femoropopliteal-occlusive-disease
#18
REVIEW
Ali F AbuRahma
Several meta-analyses and multicenter trials have shown that chronic limb ischemia did not occur for up to 5 years in 50%-70% of patients who underwent saphenous vein grafts, with limb salvage and perioperative mortality rates of >80% and 3%, respectively. However, open surgical bypass can have limitations, including postoperative morbidity/wound complications of 10%-20% and prolonged length of hospital stay and outpatient care. Several studies have analyzed clinical outcomes for patients with critical limb ischemia treated with endovascular therapies, but they have been mainly retrospective with significant heterogeneity or were single center...
March 25, 2018: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29679687/indocyanine-green-angiography-to-prognosticate-healing-of-foot-ulcer-in-critical-limb-ischemia-a-novel-technique
#19
Hiten M Patel, Shahzad S Bulsara, Shubhabrata Banerjee, Tapish Sahu, Virender K Sheorain, Tarun Grover, Rajiv Parakh
BACKGROUND: To predict wound healing in patients with critical limb ischemia (CLI) is an ongoing issue. Current methods such as ankle-brachial index (ABI), color Doppler and transcutaneous oxygen pressure (TCPO2 ), and computed tomography angiography are lacking in demonstrating regional perfusion. Indocyanine green angiography (ICGA) has the potential to provide regional perfusion information lacking in other methods. This study was conducted to demonstrate successes of revascularization procedure in CLI patients based on ICGA data...
April 19, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29661291/hemodialysis-patients-have-worse-outcomes-after-infrageniculate-revascularization-procedures
#20
Caitlin W Hicks, Joseph K Canner, Kevin Kirkland, Mahmoud B Malas, James H Black, Christopher J Abularrage
BACKGROUND: Hemodialysis (HD) has been shown to be an independent predictor of poor outcomes after femoropopliteal revascularization procedures in patients with chronic limb-threatening ischemia. However, HD patients tend to have isolated infrageniculate disease, an anatomic risk factor for inferior patency. We aimed to compare outcomes for HD versus non-HD patients after infrageniculate open lower extremity bypass (LEB) and endovascular peripheral vascular interventions (PVIs). METHODS: Data from the Society for Vascular Surgery Vascular Quality Initiative database (2008-2014) were analyzed...
June 2018: Journal of Surgical Research
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