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deep vein thromboembolism

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https://www.readbyqxmd.com/read/29429212/-the-sources-of-emboli-in-patients-with-pulmonary-embolism-diagnosed-by-autopsy
#1
H Yang, X M Xu, B M Fang
Objective: To study the sources of emboli in patients with pulmonary embolism diagnosed by autopsy, and therefore to provide help in the diagnosis and treatment of thromboembolism. Methods: We retrospectively analyzed the pathology and clinical data of 43 patients with pulmonary embolism diagnosed by autopsy from 1962 to 2012 in Beijing Hospital. Results: In patients with pulmonary embolism diagnosed by autopsy, 32.6% of the emboli came from deep veins of the lower extremities, 9.3% from the renal vein, 9.3% from the prostate sinus, 7...
February 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29420429/elevated-venous-thromboembolism-risk-following-colectomy-for-ibd-is-equal-to-those-for-colorectal-cancer-for-ninety-days-after-surgery
#2
Fadwa Ali, Sadeer G Al-Kindi, Jacqueline J Blank, Carrie Y Peterson, Kirk A Ludwig, Timothy J Ridolfi
BACKGROUND: The risk of postoperative venous thromboembolism is high in patients with colon cancer and IBD. Although The American Society of Colon and Rectal Surgeons suggests posthospital prophylaxis after surgery in patients with colon cancer, there are no such recommendations for patients with IBD. OBJECTIVE: This study aims to analyze the incidence and risk factors for postoperative venous thromboembolism. DESIGN: This was a retrospective review using the Explorys platform...
March 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29413743/safety-of-a-high-dose-tranexamic-acid-protocol-in-complex-adult-spinal-deformity-analysis-of-100-consecutive-cases
#3
James D Lin, Lawrence G Lenke, Jamal N Shillingford, Joseph L Laratta, Lee A Tan, Charla R Fischer, Mark A Weller, Ronald A Lehman
STUDY DESIGN: Retrospective review of high-dose tranexamic acid (TXA) use in consecutive patients. OBJECTIVE: To determine the safety profile of a high-dose TXA protocol in complex adult spinal deformity patients. SUMMARY OF BACKGROUND DATA: Adult spinal deformity (ASD) surgery may involve significant amounts of blood loss, especially when various osteotomy techniques are used. Antifibrinolytic agents such as TXA have been used to reduce intraoperative blood loss...
March 2018: Spine Deformity
https://www.readbyqxmd.com/read/29410163/management-of-low-risk-pulmonary-embolism-lope-patients-without-hospitalization-the-lope-prospective-management-study
#4
Joseph Bledsoe, Scott Woller, Scott Stevens, Valerie Aston, Rich Patten, Todd Allen, Benjamin Horne, Lydia Dong, James Lloyd, Greg Snow, Troy Madsen, Gregory Elliott
BACKGROUND: The efficacy and safety of managing patients with low-risk pulmonary embolism (PE) without hospitalization requires objective data from US medical centers. We sought to determine the 90-day composite rate of recurrent symptomatic venous thromboembolism (VTE), major bleeding events, and all-cause mortality among consecutive patients diagnosed with acute low-risk PE managed without inpatient hospitalization; and to measure patient satisfaction. METHODS: We performed a prospective cohort single-arm management study conducted from January 2013 to October 2016 in five emergency departments...
February 1, 2018: Chest
https://www.readbyqxmd.com/read/29408616/risk-of-venous-thromboembolism-following-peripherally-inserted-central-catheter-exchange-an-analysis-of-23-000-hospitalized-patients
#5
Vineet Chopra, Scott Kaatz, Paul Grant, Lakshmi Swaminathan, Tanya Boldenow, Anna Conlon, Steven J Bernstein, Scott A Flanders
BACKGROUND: Catheter exchange over a guidewire is frequently performed for malfunctioning peripherally inserted central catheters (PICCs). Whether such exchanges are associated with venous thromboembolism is not known. METHODS: We performed a retrospective cohort study to assess the association between PICC exchange and risk of thromboembolism. Adult hospitalized patients that received a PICC during clinical care one of 51 hospitals participating in the Michigan Hospital Medicine Safety consortium were included...
January 31, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29406795/venous-thromboembolism-risk-in-head-and-neck-cancer-significance-of-the-preoperative-platelet-to-lymphocyte-ratio
#6
Tristan Tham, Lauren Rahman, Christina Persaud, Caitlin Olson, Peter Costantino
Objective We aimed to investigate the association between the preoperative platelet-to-lymphocyte ratio (PLR) and venous thromboembolism (VTE) in patients with head and neck cancer (HNC) undergoing major surgery. Study Design Retrospective cohort study. Setting Academic tertiary hospital from 2011 to 2017. Subjects and Methods Patients with confirmed HNC undergoing major surgery were included in this study. The preoperative PLR was recorded for all patients. Known VTE risk factors, including Caprini score, age, sex, smoking, body mass index, prior VTE, and anticoagulation, were also recorded...
February 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29401105/deep-vein-thrombosis-in-a-young-healthy-baseball-catcher-a-case-report-and-review-of-the-literature
#7
Kimberly K Abood, Megan Rose Paul, Dennis John Kuo
Venous thromboembolism is becoming increasingly recognized as a significant cause of morbidity and mortality in the hospitalized pediatric population. However, young healthy athletes can present with unique risk factors for deep vein thrombosis (DVT) that can be overlooked. Here we report a case of an adolescent male with no inherited risk factors or prior history of DVTs who developed a right femoral vein DVT in the context of playing catcher in baseball after recovering from a bout of streptococcal pharyngitis...
February 2, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29399531/deep-vein-thrombosis-pathogenesis-diagnosis-and-medical-management
#8
REVIEW
Jonathan Stone, Patrick Hangge, Hassan Albadawi, Alex Wallace, Fadi Shamoun, M Grace Knuttien, Sailendra Naidu, Rahmi Oklu
Deep vein thrombosis (DVT) is a major preventable cause of morbidity and mortality worldwide. Venous thromboembolism (VTE), which includes DVT and pulmonary embolism (PE), affects an estimated 1 per 1,000 people and contributes to 60,000-100,000 deaths annually. Normal blood physiology hinges on a delicate balance between pro- and anti-coagulant factors. Virchow's Triad distills the multitude of risk factors for DVT into three basic elements favoring thrombus formation: venous stasis, vascular injury, and hypercoagulability...
December 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29399524/statins-as-a-preventative-therapy-for-venous-thromboembolism
#9
REVIEW
Alex Wallace, Hassan Albadawi, Peter Hoang, Andrew Fleck, Sailendra Naidu, Grace Knuttinen, Rahmi Oklu
The anti-inflammatory effects of statins have likely not been used to their fullest extent, particularly in reducing venous thromboembolic events. Current therapy for thrombotic events hinges on anticoagulation via heparin, warfarin or new oral anticoagulants. Interventional procedures with thrombectomy may also play a critical role. Unfortunately, thrombotic events can occur and recur despite meticulous anticoagulation therapy. Venous thromboembolism (VTE) includes both deep vein thrombosis (DVT) and pulmonary embolism (PE), two complicated and prevalent diseases that can cause chronic disease states such as post-thrombotic syndrome (PTS)...
December 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29394995/venous-thromboembolism-in-patients-hospitalized-for-lung-transplantation
#10
Jonathan K Aboagye, Jeremiah W A Hayanga, Brandyn D Lau, Errol L Bush, Dauryne L Shaffer, Deborah B Hobson, Peggy S Kraus, Michael B Streiff, Elliott R Haut, Jonathan D'Cuhna
BACKGROUND: Venous thromboembolism (VTE) is an important complication after solid organ transplantation. We sought to evaluate any association between VTE and in-hospital death, length of hospitalization, and total hospital charges for patients hospitalized for lung transplantation (LT). METHODS: We retrospectively reviewed the Nationwide Inpatient Sample to identify patients hospitalized for LT from 2000 to 2011. We evaluated the incidence of VTE during hospitalization for LT, risk factors for VTE, and the association between VTE and in-hospital death, length of hospitalization, and total hospital charges...
January 29, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29391442/deep-vein-thrombosis-in-mice-is-regulated-by-platelet-hmgb1-through-release-of-neutrophil-extracellular-traps-and-dna
#11
Mitchell R Dyer, Qiwei Chen, Shannon Haldeman, Hamza Yazdani, Rosemary Hoffman, Patricia Loughran, Allan Tsung, Brian S Zuckerbraun, Richard L Simmons, Matthew D Neal
Venous thromboembolic (VTE) disease, consisting of deep venous thrombosis (DVT) and pulmonary embolism (PE) is a leading cause of morbidity and mortality. Current prophylactic measures are insufficient to prevent all occurrence in part due to an incomplete understanding of the underlying pathophysiology. Mounting evidence describes interplay between activation of the innate immune system and thrombus development. Recent work has demonstrated that platelet release of HMGB1 leads to increased microvascular complications following injury...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29387414/role-of-p-selectin-in-thromboembolic-events-in-patients-with-cancer
#12
Lúcio Flávio Barbour Fernandes, José Humberto T G Fregnani, Célia Maria Cássaro Strunz, Adriana de Andrade Ramos Nogueira, Adhemar Longatto-Filho
The objective of the present study was to evaluate the role of P-selectin in patients with cancer with suspected thromboembolic events (TEEs). Patients with cancer have a four times greater risk of developing TEEs. P-selectin is a glycoprotein that has the function of facilitating the interaction (adhesion) of leukocytes with the endothelium, or with platelets. There is a well-defined relationship between P-selectin and thrombosis; however, it is likely that the cut-off value of P-selectin for patients with cancer should be considered differently from that of the general population...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29378357/predictors-of-post-thrombotic-ulcer-after-acute-dvt-the-riete-registry
#13
Jean-Philippe Galanaud, Laurent Bertoletti, Maria Amitrano, Carmen Fernández-Capitán, José María Pedrajas, Vladimir Rosa, Manuel Barrón, Alicia Lorenzo, Olga Madridano, Isabelle Quéré, Susan R Kahn, Paolo Prandoni, Manuel Monreal
In patients with deep-vein thrombosis (DVT) in the lower limbs, venous ulcer is the most debilitating and end-stage clinical expression of the post-thrombotic syndrome (PTS). To date, risk factors for PTS-related ulcer in DVT patients have not been identified.We used the international observational RIETE registry to assess the evolution of PTS signs and symptoms during a 3-year follow-up period and to identify independent predictors of PTS ulcer at 1 year in patients with acute DVT.Among 1,866 eligible patients, cumulative rates of PTS ulcer at 1, 2 and 3 years were 2...
February 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29376959/-clinical-experience-with-the-use-of-rivaroxaban-in-the-treatment-of-cancer-patients-with-venous-thrombosis
#14
P F Kravtsov, S E Katorkin, M A Melnicov
The urgency of the problem. The incidence of various thromboembolic complications in patients with oncopathology reaches 5-12%. When treating VTE in patients with oncology it is necessary to choose between two generally recognized alternatives. The recommended two-component scheme of the initiating phase of anticoagulant therapy with subsequent long-term admission of VKA is fraught with the development of clinically significant bleeding during the initial selection of the dose of warfarin and an increased risk of recurrence of VTE...
2018: Khirurgiia
https://www.readbyqxmd.com/read/29376955/-pathogenesis-and-prevention-of-venous-and-arterial-thromboembolic-events-in-patients-after-deep-vein-thrombosis-of-lower-extremities
#15
A A Polyantsev, P V Mozgovoy, D V Frolov, A M Linchenko, Yu V Shchelokova, T A Litvinova, Yu A Dyakova, I A Frolenko
AIM: To define the role of thrombophilic and other procoagulant conditions in pathogenesis of deep vein thrombosis and the effectiveness of pathogenetic secondary prevention of venous and arterial thromboembolic events. MATERIAL AND METHODS: The study included 107 patients for the period 2007-2016 who were divided into 3 groups. The main group (n=40) - lifelong individual antithrombotic therapy with warfarin predominantly; the second (control) group (n=39) - warfarin administration for 3-6 months; the third (additional) group (n=28) - specific life-long therapy depending on procoagulant status which was assessed according to original scale...
2018: Khirurgiia
https://www.readbyqxmd.com/read/29375141/reperfusion-after-pulmonary-embolism-long-term-follow-up-risk-factors-clinical-impact
#16
Jan Mrozek, Jana Petrova, Jana Vaclavkova, Vladimir Janovsky, Lubos Kraus, Pavel Jansa
BACKGROUND AND AIM: Thromboembolic disease is the third most common cardiovascular disorder and deep vein thrombosis carries the risk of pulmonary embolism (PE). Questions related to reperfusion after PE remain, especially risk factors. Incomplete reperfusion after PE is closely related to the development of chronic thromboembolic pulmonary hypertension. The aim of this study was to determine the relation between reperfusion after PE in the long term over a period of 24 months, laboratory results and clinical risk factors found during the initial PE event...
January 24, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29370816/prevalence-of-lower-limb-deep-venous-thrombosis-among-adult-hiv-positive-patients-attending-an-outpatient-clinic-at-mulago-hospital
#17
Sosthene Tsongo Vululi, Samuel Bugeza, Muyinda Zeridah, Henry Ddungu, Akello Betty Openy, Mubiru Frank, Rosalind Parkes-Ratanshi
BACKGROUND: Deep venous thrombosis (DVT) and its major complication pulmonary embolism (PE) are collectively known as venous thromboembolism. In Uganda, the prevalence of DVT among HIV patients has not been previously published. The aim of the study was to determine the prevalence and sonographic features of lower limb deep venous thrombosis among HIV positive patients on anti-retroviral treatment (ART). METHODS: This was a cross sectional study in which HIV positive patients on ART were recruited from an out-patient HIV clinic at Mulago National Referral Hospital...
January 25, 2018: AIDS Research and Therapy
https://www.readbyqxmd.com/read/29370290/incidence-of-venous-thromboembolism-in-korea-from-2009-to-2013
#18
Junshik Hong, Ju Hyun Lee, Ho-Young Yhim, Won-Il Choi, Soo-Mee Bang, Heeyoung Lee, Doyeun Oh
The incidence of venous thromboembolism (VTE) is lower in Asian populations than in Western populations. The objective of the present study was to evaluate the annual age- and sex-adjusted incidence (ASR) of VTE from 2009 to 2013 in South Korea. In addition, annual change in the pattern of VTE treatment during the study period was estimated because a new direct oral anticoagulant (DOAC) had become available and was covered by health insurance in Korea beginning in January 2013. VTE cases from 2009 to 2013 were retrospectively identified based on both diagnostic and medication codes of anticoagulants used for initial treatment using the Korean Health Insurance Review and Assessment Service (HIRA) databases...
2018: PloS One
https://www.readbyqxmd.com/read/29370050/impact-of-venorrhaphy-and-vein-ligation-in-isolated-lower-extremity-venous-injuries-on-venous-thromboembolism-and-edema
#19
Nathan R Manley, Louis J Magnotti, Timothy C Fabian, Martin A Croce, John P Sharpe
BACKGROUND: Following venous injury, venorrhaphy can restore outflow, although it risks thrombosis and venous thromboembolism (VTE). Vein ligation is a faster option, although it potentially risks extremity edema. The purpose of this study was to evaluate the management of venous injury on VTE and extremity edema in patients with isolated lower-extremity venous injuries. METHODS: Patients with common iliac, external iliac, and femoral venous injuries over a 10-year period were stratified by age, shock, management of venous injury, injury severity, and timing and type of anticoagulation...
February 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29367902/venous-thromboembolism-prophylaxis-after-total-knee-arthroplasty-tka-aspirin-vs-rivaroxaban
#20
Jose Luiz Colleoni, Fernando Noel Ribeiro, Paulo Augusto Castro Mos, João Paulo Reis, Henrique Rosa de Oliveira, Beatriz Kawata Miura
Objectives: To compare the efficacy and safety of aspirin and rivaroxaban in preventing venous thromboembolism (VTE) after total knee arthroplasty (TKA). Methods: Thirty-two patients with osteoarthritis of the knee and knee arthroplasty indication were selected. The operated patients were randomized into two groups (A and B). Group A received 300 mg of acetylsalicylic acid (aspirin) and Group B received 10 mg of rivaroxaban daily for 14 days. Follow-up was performed weekly for four weeks and evaluated the presence of signs and symptoms of DVT, the healing of the surgical wound, and possible local complications such as hematoma, and superficial or deep infection that required surgical approach...
January 2018: Revista Brasileira de Ortopedia
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