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deep vein thromboembolism

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https://www.readbyqxmd.com/read/29661366/a-systematic-review-of-venous-aneurysms-by-anatomic-location
#1
REVIEW
Katherine A Teter, Thomas M Maldonado, Mark A Adelman
OBJECTIVE: Venous aneurysms are uncommon vascular abnormalities that may be identified anywhere in the body. Historically, they were often misdiagnosed as soft tissue lesions, but with the advent of readily available noninvasive imaging (such as duplex ultrasound), they can now be easily identified. Our aim was to review the presentation of venous aneurysms, available imaging modalities for defining them, and management. METHODS: The English-language literature before March 2017 was reviewed, and only reports of primary venous aneurysms of the deep veins were included...
May 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29660351/association-of-low-hemoglobin-with-symptomatic-venous-thromboembolism-in-acutely-ill-hospitalized-medical-patients-an-apex-trial-substudy
#2
Gerald Chi, C Michael Gibson, Adrian F Hernandez, Russell D Hull, Syed Hassan A Kazmi, Ahmed Younes, Sargun S Walia, Anmol Pitliya, Amandeep Singh, Farima Kahe, Arzu Kalayci, Tarek Nafee, Mathieu Kerneis, Fahad AlKhalfan, Alexander T Cohen, Robert A Harrington, Samuel Z Goldhaber
BACKGROUND: Anemia is a common finding and independent predictor for adverse outcomes in hospitalized patients with medical illness. It remains unclear whether anemia is a risk factor for venous thromboembolism and whether the presence of anemia can refine risk assessment for prediction of venous thromboembolism, thereby adding incremental utility to a validated model. METHODS: In the APEX trial, 7,513 hospitalized medical patients were randomized to receive either betrixaban or standard-of-care enoxaparin for thromboprophylaxis...
April 13, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29657152/venous-thromboembolism-in-systemic-sclerosis-prevalence-risk-factors-and-effect-on-survival
#3
Sindhu R Johnson, Nabil Hakami, Zareen Ahmad, Duminda N Wijeysundera
OBJECTIVE: Whether systemic sclerosis (SSc) confers increased risk of venous thromboembolism (VTE) is uncertain. We evaluated the prevalence, risk factors, and effect of VTE on SSc survival. METHODS: A cohort study was conducted of subjects with SSc who fulfilled the American College of Rheumatology/European League Against Rheumatism classification criteria between 1970 and 2017. Deep vein thrombosis was defined as thrombus on extremity ultrasound. Pulmonary embolism was defined as thrombus on thorax computed tomography angiogram...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29655462/obesity-thrombotic-risk-and-inflammation-in-cancer
#4
Benjamín Rubio-Jurado, Luz-Ma-Adriana Balderas-Peña, Eduardo E García-Luna, María G Zavala-Cerna, Carlos Riebeling-Navarro, Pedro A Reyes, Arnulfo H Nava-Zavala
Neoplasms exhibits a high incidence and mortality rates due to their complex and commonly overlapping clinical, biochemical, and morphologic profiles influenced by acquired or inherited molecular abnormalities, cell of origin, and level of differentiation. Obesity appears related to ~20% of cancers including endometrial, esophageal, colorectal, postmenopausal breast, prostate, and renal. Several factors other than obesity, i.e., insulin, insulin-like growth factor, sexual hormones, and adipokines may play a potential role in neoplasia...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29653390/fondaparinux-versus-nadroparin-for-thromboprophylaxis-following-minimally-invasive-esophagectomy-a-randomized-controlled-trial
#5
Jieqiong Song, Lizhen Xuan, Wei Wu, Yaxing Shen, Lijie Tan, Ming Zhong
BACKGROUND: The methodology of thromboprophylaxis post minimally invasive esophagectomy (MIE) is unclear. Thus, we compared the efficacy and safety of fondaparinux and nadroparin on the prophylaxis of venous thromboembolism (VTE) after MIE. MATERIALS AND METHODS: We conducted a randomized, double-blind, treatment-controlled study. Consecutive patients undergoing MIE randomly received a single dose of either nadroparin 2850 AxaIU (Group H) or fondaparinux 2.5 mg (Group F) daily...
April 4, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29652041/-alternating-pneumocompression-effective-physiotherapeutic-method-for-the-prevention-of-venous-thromboembolic-complications-in-patients-of-medium-and-high-risk-in-the-acute-period-of-the-stroke
#6
I Y Galyaev
BACKGROUND: the patients presenting with severe post-stroke in the acute period of this condition are characterized by the high risk of venous thromboembolic complications (VTEC), with the most dangerous of them being pulmonary embolism that makes an appreciable contribution to the mortality rate of such patients at the hospital stage of their treatment. Among the physical methods for the prevention of VTE, such as wearing graduated compression stockings (GCS), myoelectrostimulation (MES), pneumatic intermittent compression (PIC), only the latter technique has been shown to be efficient when applied for the treatment of surgical patients during the post-stroke period with the level of evidence 2B and the very uncertain parameters of the impact...
April 9, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29649062/national-mortality-rates-after-outpatient-cosmetic-surgery-and-low-rates-of-perioperative-deep-vein-thrombosis-screening-and-prophylaxis
#7
Alexandra Bucknor, Sabine Egeler, Austin Chen, Anmol Chattha, Parisa Kamali, Gary Brownstein, Lawrence Reed, David Watts, Samuel J Lin
BACKGROUND: Concerns have arisen over reports of deaths occurring after certain outpatient plastic surgery procedures. Here, we present a detailed analysis of the American Association for the Accreditation of Ambulatory Surgical Facilities (AAAASF) database and report on deaths occurring after outpatient cosmetic surgical procedures, causative factors, and venous thromboembolism (VTE) screening rates. METHODS: A retrospective analysis of the AAAASF database was performed for the years 2012-2017...
March 29, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29629359/extended-duration-treatment-of-superficial-vein-thrombosis-of-the-lower-limbs-with-tinzaparin
#8
Konstantinos M Nikolakopoulos, Stavros K Kakkos, Chrysanthi P Papageorgopoulou, Ioannis A Tsolakis
Purpose: To identify risk factors for recurrent thromboembolic events (RTEs) and define the optimum duration of treatment with tinzaparin in patients with superficial vein thrombosis (SVT) of the lower limbs. Materials and Methods: A total of 147 consecutive patients with significant SVT were treated with subcutaneously administered tinzaparin. The composite primary endpoint of the study was RTE, deep-vein thrombosis (DVT) and/or pulmonary embolism (PE) at 120 days...
March 2018: Vascular Specialist International
https://www.readbyqxmd.com/read/29628468/induction-of-anti-pf4-heparin-antibodies-after-arthroplasty-for-rheumatic-diseases
#9
Kiyoshi Migita, Tomoyuki Asano, Shuzo Sato, Satoru Motokawa
Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. These pathogenic antibodies against PF4/heparin bind and activate cellular FcγRIIa on platelets to induce a hypercoagulable state culminating in thrombosis. Recent studies indicate several conditions, including joint surgery, induce spontaneous HIT, which can occur without exposure to heparin. To determine the real-world evidences concerning the incidences of venous thromboembolism (VTE) after total joint arthroplasty for rheumatic disease, we conducted a multicenter cohort study (J-PSVT) designed to document the VTE and seroconversion rates of anti-PF4/heparin antibody in 34 Japanese National hospital organization (NHO) hospitals...
April 7, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29626305/prevalence-and-predictors-of-preoperative-venous-thromboembolism-in-asymptomatic-patients-undergoing-major-oncologic-surgery
#10
Melanie L Gainsbury, Jennifer Erdrich, Dani Taubman, James Mirocha, Nicholas Manguso, Farin Amersi, Allan W Silberman
BACKGROUND: Postoperative venous thromboembolism (VTE) is a leading cause of in-hospital mortality for cancer patients; however, the prevalence of preoperative VTE remains unclear. OBJECTIVE: The aim of this study was to evaluate the prevalence and risk factors associated with preoperative VTE in asymptomatic patients undergoing major oncologic surgery. METHODS: Retrospective analysis of 346 patients identified from our prospectively maintained database of patients undergoing abdominopelvic oncologic surgery from 2009 to 2016...
April 6, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29625928/serum-free-light-chain-difference-and-%C3%AE-2-microglobulin-levels-are-risk-factors-for-thromboembolic-events-in-patients-with-al-amyloidosis
#11
Hyunkyung Park, Ji-Won Kim, Jeonghwan Youk, Youngil Koh, Jeong-Ok Lee, Ki Hwan Kim, Soo-Mee Bang, Inho Kim, Seonyang Park, Sung-Soo Yoon
BACKGROUND: AL amyloidosis might increase the risk of thromboembolism and other plasma cell dyscrasias; however, only a few reports have described the clinical features of thromboembolism. The present study aimed to elucidate the clinical features of thromboembolic events and to identify the risk factors for these events. MATERIALS AND METHODS: The medical records were retrospectively reviewed to define the clinically significant thromboembolic events. RESULTS: A total of 106 patients with biopsy-proven AL amyloidosis were included...
March 15, 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29623504/coarse-grained-molecular-dynamics-simulations-of-fibrin-polymerization-effects-of-thrombin-concentration-on-fibrin-clot-structure
#12
Sumith Yesudasan, Xianqiao Wang, Rodney D Averett
Studies suggest that patients with deep vein thrombosis and diabetes often have hypercoagulable blood plasma, leading to a higher risk of thromboembolism formation through the rupture of blood clots, which may lead to stroke and death. Despite many advances in the field of blood clot formation and thrombosis, the influence of mechanical properties of fibrin in the formation of thromboembolisms in platelet-poor plasma is poorly understood. In this paper, we combine the concepts of reactive molecular dynamics and coarse-grained molecular modeling to predict the complex network formation of fibrin clots and the branching of fibrin monomers...
April 5, 2018: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29623408/-thromboembolism-prophylaxis-in-old-age
#13
Gabriele Röhrig, Gerald Kolb
Anticoagulation in geriatric patients is challenging regarding the risk of bleeding complications and thromboembolic problems. Age, comorbidities, such as renal insufficiency and polymedication have a vital impact on bleeding and thromboembolic risks; however, age is not an exclusion criterion for withholding anticoagulation. Age is the main risk factor for deep vein thrombosis and atrial fibrillation becomes more relevant with aging. Older patients with atrial fibrillation have a particularly high risk of having a stroke...
April 5, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29622878/the-influence-of-cyp2c9-and-vkorc1-gene-polymorphisms-on-the-response-to-warfarin-in-egyptians
#14
Ahmed M L Bedewy, Salah Showeta, Mostafa Hasan Mostafa, Lamia Saeed Kandil
Warfarin is the most commonly used drug for chronic prevention of thromboembolic events, it also ranks high among drugs that cause serious adverse events. The variability in dose requirements has been attributed to inter-individual differences in medical, personal, and genetic factor. Cytochrome P-450 2C9 is the principle enzyme that terminates the anticoagulant effect of warfarin by catalyzing the conversion of the pharmacologically more potent S-enantiomer to its inactive metabolites. Warfarin exerts its effect by inhibition of vitamin K epoxide reductase...
April 2018: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29618152/altered-plasma-clot-properties-and-trauma-related-venous-thromboembolism-despite-thromboprophylaxis
#15
Sarah Goldman, Paulina Frączek, Krzysztof Szklanny, Elżbieta Papuga-Szela, Andrzej Stanisz, Anetta Undas
BACKGROUND:  Prothrombotic clot phenotype may characterize patients developing deep vein thrombosis (DVT) despite pharmacological thromboprophylaxis. We studied the role of fibrin clot properties and its potential determinants in individuals who experienced DVT after lower limb injury. METHODS:  In a case-control study, we assessed 50 patients who developed DVT despite prophylactic use of low-molecular-weight heparins (the failed thromboprophylaxis group) after a lower limb injury, and three age- and sex-matched control groups, 50 patients each: (1) patients with trauma-related DVT without prior thromboprophylaxis; (2) individuals with unprovoked DVT; (3) patients without history of DVT (the no-DVT controls)...
April 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29593386/lack-of-association-between-airflow-limitation-and-recurrence-of-venous-thromboembolism-among-cancer-patients-with-pulmonary-embolism
#16
Sun Hye Shin, Danbee Kang, Juhee Cho, Haseong Chang, Min Sun Kim, Su Yeon Lee, Hyun Lee, Hojoong Kim, Duk-Kyung Kim, Eun Kyoung Kim, Hye Yun Park
Background: COPD is a well-known risk factor for venous thromboembolism (VTE) development. However, recent data showed that it was not associated with VTE recurrence risk, which excluded cancer patients. This study investigated the association of airflow limitation and VTE recurrence in cancer patients with pulmonary embolism (PE). Methods: This is a retrospective cohort study of cancer patients with newly diagnosed PE at a university hospital. PE was confirmed using contrast-enhanced computed tomography scan...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29588079/risk-of-cardiovascular-disease-and-venous-thromboembolism-among-patients-with-incident-anca-associated-vasculitis-a-20-year-population-based-cohort-study
#17
Alvise Berti, Eric L Matteson, Cynthia S Crowson, Ulrich Specks, Divi Cornec
OBJECTIVE: To assess the cardiovascular disease (CVD) and venous thromboembolism (VTE) risks among patients with newly diagnosed antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV). PATIENTS AND METHODS: A population-based incident AAV cohort of 58 patients diagnosed between 1996 and 2015 in Olmsted County, MN, was identified by medical record review. For each patient, 3 age- and sex-matched non-AAV comparators were randomly selected from the same population and assigned an index date corresponding to the AAV incidence date...
March 24, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29580830/myocardial-injury-is-more-common-than-deep-venous-thrombosis-after-vascular-surgery-and-is-associated-with-a-high-one-year-mortality-risk
#18
Jacek Górka, Kamil Polok, Jakub Fronczek, Karolina Górka, Mateusz Kózka, Paweł Iwaszczuk, Marzena Frołow, P J Devereaux, Bruce Biccard, Jacek Musiał, Wojciech Szczeklik
OBJECTIVE/BACKGROUND: Venous thromboembolism (VTE) has been considered the dominant major life threatening vascular complication after non-cardiac surgery, but recent studies have shifted the emphasis toward myocardial injury after non-cardiac surgery (MINS) as a common adverse event in the peri-operative setting. The aim of the present study was to compare the incidence and influence on mortality of two dominant venous and arterial events in the peri-operative period by prospectively screening a consecutive cohort of patients undergoing vascular surgery...
March 23, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29579573/cardiovascular-ultrasonography-detection-of-embolic-sources-in-trauma
#19
Theodosios Saranteas, Andreas F Mavrogenis, John Poularas, Andreas Kostroglou, Christina Mandila, Fotios Panou
Venous thromboembolism (deep vein thrombosis and pulmonary embolism) and bone cement implantation syndrome are major sources of embolic events in trauma patients. In these patients, embolic events due to venous thromboembolism and bone cement implantation syndrome have been detected with cardiac and vascular ultrasonography in the emergency setting, during the perioperative period, and in the intensive care unit. This article discusses the ultrasonography modalities and imaging findings of embolic events related to venous thromboembolism and bone cement implantation syndrome...
March 19, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29575675/novel-oral-anticoagulant-use-in-adult-fontan-patients-a-single-center-experience
#20
Justin Georgekutty, Amir Kazerouninia, YunFei Wang, Peter R Ermis, Dhaval R Parekh, Wayne J Franklin, Wilson W Lam
OBJECTIVE: Adult Fontan patients are at increased risk for thrombosis and thromboembolic complications leading to increased morbidity and mortality. Most are prescribed antiplatelet or anticoagulant therapy for thromboprophylaxis; novel oral anticoagulants (NOACs) are uncommonly used given lack of data on their use in this population and generalized concerns regarding Fontan patients' abnormal coagulation. We report the largest single-center experience with the use of NOACs for treatment and prophylaxis of thrombosis and thromboembolism in adult Fontan patients...
March 24, 2018: Congenital Heart Disease
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