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deep vein thromboembolism

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https://www.readbyqxmd.com/read/29893601/posttraumatic-deep-vein-thrombosis-in-collegiate-athletes-an-exploration-clinical-case-series
#1
Chris Hummel, Paul R Geisler, Tim Reynolds, Todd Lazenby
BACKGROUND:   Although athletes are typically at low risk for developing venous thromboembolism (VTE), injured and noninjured athletes alike can be exposed to many acquired risk factors, including intense training, dehydration, trauma, immobilization, oral contraceptive use, and long-distance travel. Additionally, the risk of developing VTE might be increased by unidentified genetic clotting disorders. Due to the potential for fatal outcomes, knowledge of VTE pathoetiology and recognition of deep vein thrombosis (DVT) presentation should be an inherent part of the evaluation process for all who attend to athletes, regardless of age and apparent risk profile...
June 12, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29889287/association-between-sickle-cell-trait-with-selected-chronic-medical-conditions-in-u-s-service-members
#2
David W Niebuhr, Ligong Chen, Stephanie Shao, Jonathan Goldsmith, Celia Byrne, Darrell E Singer
Introduction: Sickle cell trait (SCT), the heterozygous carrier state for hemoglobin S, is present in an estimated 1.6% of all newborns and 7.3% in black individuals in the USA. SCT has long been considered a benign condition with anticipated normal life expectancy and no increased risk for chronic diseases. The medical literature is inconclusive on the potential association between SCT and chronic medical conditions (CMC) including chronic kidney disease, venous thromboembolism, and stroke...
June 8, 2018: Military Medicine
https://www.readbyqxmd.com/read/29889260/pulmonary-infarction-right-upper-quadrant-pain-as-a-presenting-symptom-with-review-of-typical-computed-tomography-imaging-features
#3
Steven T Fosmire, Guy N Gibson, John C Copeland, Marcus S Maydew, Christian Eggers
The purpose of this case presentation is to discuss right upper quadrant pain as an atypical presenting symptom in pulmonary infarction and review the typical computed tomography (CT) imaging features of pulmonary infarction to improve diagnostic accuracy. Pulmonary infarction results from occlusion of distal arterial vasculature within the lung parenchyma leading to ischemia, hemorrhage, and ultimately necrosis. Patients with lung infarction typically present with pleuritic chest pain and may have associated signs or symptoms of pulmonary thromboembolism or deep vein thrombosis...
June 8, 2018: Military Medicine
https://www.readbyqxmd.com/read/29885792/temporal-trends-in-venous-thromboembolism-after-radical-cystectomy
#4
Timothy D Lyon, Matthew K Tollefson, Paras H Shah, Katherine Bews, Igor Frank, R Jeffrey Karnes, R Houston Thompson, Elizabeth B Habermann, Stephen A Boorjian
PURPOSE: To determine whether the rate of venous thromboembolism (VTE) following radical cystectomy (RC) is changing overtime. MATERIALS AND METHODS: The American College of Surgeons National Surgical Quality Improvement Program database was used to identify patients who underwent RC for bladder cancer from 2011 to 2016. VTE was defined as pulmonary embolism or deep vein thrombosis within 30 days of RC. VTE rate by year was assessed using the Cochran-Armitage test for trend...
June 6, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29881160/effects-of-fondaparinux-on-wound-drainage-after-total-hip-and-knee-arthroplasty
#5
Zachary C Lum, Rene A Monzon, Jose Bosque, Sheldon Coleman, Gavin C Pereira, Paul E Di Cesare
Background: The purpose of this investigation was to determine the effects of fondaparinux on postoperative wound drainage, length of hospital stay (LOS) and rate of surgical site infection in total joint patients. Methods: 117 patients undergoing total joint arthroplasty treated with fondaparinux for venous thromboembolism (VTE) prophylaxis were prospectively studied. Results: The average time to a dry wound was 3.4 days, with an average LOS of 3...
June 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29880534/recombinant-tissue-plasminogen-activator-treatment-of-pulmonary-embolism-also-improves-deep-venous-thrombosis
#6
Mukremin Er
Anticoagulants are the standard form of treatment used in deep vein thrombosis (DVT). Thrombolytic therapy is another method to treat thromboembolism by using intravenous administration of streptokinase, urokinase and recombinant tissue plasminogen activator (r-tPA). We have investigated the effect of r-tPA, a systemic thrombolytic used for the treatment of pulmonary emboli, on DVT in the same patients. 130 patients who were diagnosed with both pulmonary embolism and DVT were included in this study. Lower extremity Doppler ultrasonography (DUS) was conducted on all of the patients upon admission and then on the 6th month...
June 6, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29876696/prophylaxis-of-postoperative-venous-thromboembolism-using-enoxaparin-after-esophagectomy-a-prospective-observational-study-of-effectiveness-and-safety
#7
Naoya Yoshida, Yoshifumi Baba, Yuji Miyamoto, Masaaki Iwatsuki, Yukiharu Hiyoshi, Takatsugu Ishimoto, Yu Imamura, Masayuki Watanabe, Hideo Baba
BACKGROUND: The incidence of venous thromboembolism (VTE) after esophagectomy is higher than in other gastroenterological cancer surgery. Although the effectiveness and safety of thromboprophylaxis using enoxaparin have been established in orthopedic, abdominal, and pelvic surgeries, no studies regarding esophagectomy are available. METHODS: A prospective observational study was conducted to elucidate the usefulness of enoxaparin for VTE prophylaxis after esophagectomy...
June 6, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29876671/validating-the-role-of-abo-blood-type-in-risk-of-perioperative-venous-thromboembolism-after-radical-cystectomy
#8
Sumeet Bhanvadia, Kayvan Kazerouni, Soroush T Bazargani, Gus Miranda, Jie Cai, Siamak Daneshmand, Hooman Djaladat
PURPOSE: To validate the relationship between ABO blood type and risk of VTE post-RC in a large retrospective database. METHODS: Patients with urothelial bladder cancer (UBC) who underwent RC (intent-to-cure) for whom ABO blood type was available between 2003 and 2015 were identified from our IRB-approved database. VTE was defined as deep vein thrombosis (DVT) or pulmonary embolism (PE) within 90 days of surgery. VTE prophylaxis consisted of immediate postoperative Coumadin (2003-2009), unfractionated heparin (UFH) during hospitalization (2009-2015), and UFH during hospitalization plus 4 weeks of enoxaparin after discharge (2013-2015)...
June 6, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29876337/the-role-of-inflammation-in-venous-thromboembolism
#9
REVIEW
Brian R Branchford, Shannon L Carpenter
Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT), and pulmonary embolism (PE), is becoming increasingly recognized as a cause of morbidity and mortality in pediatrics, particularly among hospitalized children. Furthermore, evidence is accumulating that suggests the inflammatory response may be a cause, as well as consequence, of VTE, but current anticoagulation treatment regimens are not designed to inhibit inflammation. In fact, many established clinical VTE risk factors such as surgery, obesity, cystic fibrosis, sepsis, systemic infection, cancer, inflammatory bowel disease, and lupus likely modulate thrombosis through inflammatory mediators...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29872303/incidence-of-venous-thromboembolism-in-psychiatric-inpatients-a-chart-review
#10
Masahiro Takeshima, Hiroyasu Ishikawa, Kazumi Shimizu, Takashi Kanbayashi, Tetsuo Shimizu
Purpose: Venous thromboembolism (VTE) is the combination of pulmonary embolism (PE) and deep vein thrombosis. In recent years, VTE has been gaining attention in the field of psychiatry as it can cause sudden deaths in patients hospitalized in psychiatric departments. The purpose of this study was to investigate the incidence of VTE in psychiatric inpatients using contrast-enhanced computed tomography (CT). Patients and methods: At the psychiatric department of the Akita University Hospital, NANOPIA® D-dimer was measured in patients with suspected symptomatic VTE or believed to be at risk for asymptomatic VTE...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29872242/novel-anticoagulant-treatment-for-pulmonary-embolism-with-direct-oral-anticoagulants-phase-3-trials-and-clinical-practice
#11
REVIEW
Cécile Tromeur, Liselotte M van der Pol, Albert T A Mairuhu, Christophe Leroyer, Francis Couturaud, Menno V Huisman, Frederikus A Klok
Anticoagulant therapy is the cornerstone of therapeutic management in acute venous thromboembolism (VTE), consisting of pulmonary embolism and deep vein thrombosis. Direct oral anticoagulants (DOACs) have become the standard of care because of their good safety profile and ease of use in clinical practice. Indeed, phase 3 randomized trials (AMPLIFY, EINSTEIN, RECOVER, and HOKUSAI studies) showed that DOACs provided a similar efficacy and a better safety than conventional treatment with parenteral heparin with overlapping loading dose of vitamin K antagonists in acute VTE therapeutic management...
June 2018: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/29866416/pulmonary-thromboembolism-after-carbon-monoxide-poisoning-a-case-series-and-review-of-the-literature
#12
Yoonje Lee, Tae Ho Lim, Hyunggoo Kang, Jaehoon Oh, Byuk Sung Ko
OBJECTIVE: Carbon monoxide (CO) poisoning is known to increase thrombotic tendency, and the risk of deep vein thrombosis in individuals who have experienced CO poisoning is higher than in the general population. However, there are a few reports describing cases of pulmonary thromboembolisms (PTE) secondary to CO poisoning. DATA SOURCES: Retrospective data analysis. STUDY SELECTION: Seven hundred fifty bed tertiary university affiliated hospital...
May 29, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29865896/association-of-genetic-variability-in-selected-genes-in-patients-with-deep-vein-thrombosis-and-platelet-hyperaggregability
#13
Juraj Sokol, Maria Skerenova, Jela Ivankova, Tomas Simurda, Jan Stasko
The aim of this study was to evaluate the genetic variability of the selected single nucleotide polymorphisms (SNPs) and examine the association between these SNPs and risk for deep vein thrombosis (DVT) in patients with sticky platelet syndrome (SPS). We examined 84 patients with SPS and history of DVT and 101 healthy individuals. We were interested in 2 SNPs within platelet endothelial aggregation receptor 1 (PEAR1) gene (rs12041331 and rs12566888), 2 SNPs within mkurine retrovirus integration site 1 gene (rs7940646 and rs1874445), 1 SNP within Janus kinase 2 gene (rs2230722), 1 SNP within FCER1G gene (rs3557), 1 SNP within pro-platelet basic protein (rs442155), 4 SNPs within alpha2A adrenergic receptor 2A (ADRA2A; rs1800545, rs4311994, rs11195419, and rs553668), and 1 SNP within sonic hedgehog gene (rs2363910)...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29864786/genome-wide-expression-analysis-suggests-hypoxia-triggered-hyper-coagulation-leading-to-venous-thrombosis-at-high-altitude
#14
Prabhash Kumar Jha, Anita Sahu, Amit Prabhakar, Tarun Tyagi, Tathagata Chatterjee, Prathima Arvind, Jiny Nair, Neha Gupta, Babita Kumari, Velu Nair, Nitin Bajaj, Jayashree Shanker, Manish Sharma, Bhuvnesh Kumar, Mohammad Zahid Ashraf
Venous thromboembolism (VTE), a multi-factorial disease, is the third most common cardiovascular disease. Established genetic and acquired risk factors are responsible for the onset of VTE. High altitude (HA) also poses as an additional risk factor, predisposing individuals to VTE; however, its molecular mechanism remains elusive. This study aimed to identify genes/pathways associated with the pathophysiology of deep vein thrombosis (DVT) at HA. Gene expression profiling of DVT patients, who developed the disease, either at sea level or at HA-DVT locations, resulted in differential expression of 378 and 875 genes, respectively...
June 4, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29850139/early-surgical-treatment-in-patients-with-pulmonary-embolism-and-thrombus-in-transit
#15
Francisco Galeano-Valle, Pablo Demelo-Rodríguez, Irene García-Fernández-Bravo, Hugo Rodríguez-Abella, Ángela Irabien-Ortiz, Ramón Fortuny-Ribas, Jorge Del Toro-Cervera
Background: Floating right heart thrombi (RHT) are in transit from the legs to the pulmonary arteries and thus are a severe form of venous thromboembolism (VTE), with a high early mortality rate without treatment. There is a lack of evidence-based recommendations for its management. The objective of this study is to describe our experience in the surgical management of thrombus-in-transit and pulmonary embolism (PE) in a tertiary hospital. Methods: We recruited four patients with thrombus-in-transit and PE treated with early surgical embolectomy and anticoagulation...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29850126/the-significance-of-perioperative-coagulation-and-fibrinolysis-related-parameters-after-lung-surgery-for-predicting-venous-thromboembolism-a-prospective-single-center-study
#16
Bo Tian, Chunfeng Song, Hui Li, Wenqian Zhang, Qirui Chen, Shuo Chen, Yili Fu, Xiaoxing Hu, Bin You, Tong Li, Bin Hu, Shengcai Hou
Background: The high incidence of venous thromboembolism (VTE) has been perceived in post thoracic surgery patients. However, the significance of perioperative coagulation and fibrinolysis related parameters after lung surgery for VTE predicting is not clear. To investigate that, we conducted a prospective single center study. Methods: A total of 111 patients undergoing lung surgery were enrolled in this study, included 52 primary lung cancer patients and 59 benign lung disease patients from July 2016 to March 2017...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29843918/prevalence-and-correlates-of-bleeding-and-emotional-harms-in-a-national-us-sample-of-patients-with-venous-thromboembolism-a-cross-sectional-structural-equation-model
#17
Michael Feehan, Michael Walsh, Heather Van Duker, Jon Godin, Mark A Munger, Ryan Fleming, Stacy A Johnson, Margaux A Morrison, Margaret M DeAngelis, Daniel M Witt
INTRODUCTION: Venous thromboembolism (VTE) including deep vein thrombosis (DVT) or pulmonary embolism (PE) is associated with reduced survival, poorer quality of life, and substantial health-care-costs. Limited research, primarily qualitative, suggests that those with VTE may have elevated fear of recurrence, and associated emotional dysfunction and distress. METHODS: A national online survey was administered to 907 patients who had experienced a VTE event in the past two years...
May 23, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29807000/arterial-ischemic-events-are-a-major-complication-in-cancer-patients-with-venous-thromboembolism
#18
Benjamin Brenner, Behnood Bikdeli, Inna Tzoran, Olga Madridano, Raquel López-Reyes, José María Suriñach, Ángeles Blanco-Molina, Antonella Tufano, Juan José López Núñez, Javier Trujillo-Santos, Manuel Monreal
BACKGROUND: Venous thromboembolism is common in patients with malignancies, affecting up to 10% of this patient population. The association between arterial ischemic events and venous thromboembolism has been also established. However, the influence of arterial ischemic events on outcomes in cancer patients with venous thromboembolism has not been fully determined. METHODS: The current study analyzed clinical characteristics, time-course, risk factors, incidence and severity of venous thromboembolism recurrences, arterial ischemic events and major bleeding in 5,717 patients with active cancer and venous thromboembolism recruited into RIETE (multi-center prospective registry of patients with objectively confirmed venous thromboembolism)...
May 25, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29798688/thirteen-year-trend-in-the-persistence-with-vitamin-k-antagonists-for-venous-thromboembolism-in-the-uk-a-cohort-study
#19
Carlos Martinez, Anja Katholing, Kerstin Folkerts, Stephan Rietbrock
BACKGROUND: Venous thromboembolism (VTE) comprises deep vein thrombosis (DVT) and pulmonary embolism (PE) and is associated with significant recurrence and mortality risk. Standard VTE treatment includes at least three months anticoagulation. The objective was to describe time trends in the duration of oral anticoagulation in patients initially treated with vitamin K antagonists (VKAs). METHODS: A retrospective cohort study was conducted on patients with first VTE and VKA treatment initiation within 30 days, identified from the UK Clinical Practice Research Datalink from 2001 to 2014...
May 25, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29794796/high-preoperative-serum-leptin-level-is-an-independent-risk-factor-for-deep-vein-thrombosis-after-total-knee-arthroplasty-in-osteoarthritis-patients-a-prospective-and-cross-sectional-study
#20
Wanli Lu, Sheng Zhou, Long Xue, Bingyang Dai, Liang Qiao, Dongyang Chen, Zhihong Xu, Yao Yao, Huajian Teng, Qing Jiang
It suggests that a high leptin level may increase the risk of venous thromboembolism (VTE) in animal studies. However, clinical studies in this field are still largely unexplored. Our objective was to evaluate the relationship between the preoperative serum leptin levels and postoperative VTE incidence in osteoarthritis (OA) patients who underwent total knee arthroplasty (TKA) at our institute.We conducted a prospective and cross-sectional study in these OA patients from March 2014 to March 2016. Preoperative leptin levels were analyzed by Luminex assays...
May 2018: Medicine (Baltimore)
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