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Vit C

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https://www.readbyqxmd.com/read/28912655/chronic-eccentric-exercise-and-antioxidant-supplementation-effects-on-lipid-profile-and-insulin-sensitivity
#1
Christina Yfanti, Athanasios Tsiokanos, Ioannis G Fatouros, Anastasios A Theodorou, Chariklia K Deli, Yiannis Koutedakis, Athanasios Z Jamurtas
Eccentric exercise has been shown to exert beneficial effects in both lipid profile and insulin sensitivity. Antioxidant supplementation during chronic exercise is controversial as it may prevent the physiological training-induced adaptations. The aim of this study was to investigate: 1) the minimum duration of the eccentric exercise training required before changes on metabolic parameters are observed and 2) whether antioxidant supplementation during training would interfere with these adaptations. Sixteen young healthy men were randomized into the Vit group (1 g of vitamin C and 400 IU vitamin E daily) and the placebo (PL) group...
September 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28879460/vitamin-b6-reduces-neurochemical-and-long-term-cognitive-alterations-after-polymicrobial-sepsis-involvement-of-the-kynurenine-pathway-modulation
#2
Lucinéia Gainski Danielski, Amanda Della Giustina, Mariana Pereira Goldim, Drielly Florentino, Khiany Mathias, Leandro Garbossa, Rosiane de Bona Schraiber, Ana Olívia Martins Laurentino, Marina Goulart, Monique Michels, Karina Barbosa de Queiroz, Markus Kohlhof, Gislaine Tezza Rezin, Jucélia Jeremias Fortunato, Joao Quevedo, Tatiana Barichello, Felipe Dal-Pizzol, Roney S Coimbra, Fabricia Petronilho
Neurological dysfunction as a result of neuroinflammation has been reported in sepsis and cause high mortality. High levels of cytokines stimulate the formation of neurotoxic metabolites by kynurenine (KYN) pathway. Vitamin B6 (vit B6) has anti-inflammatory and antioxidant properties and also acts as a cofactor for enzymes of the KYN pathway. Thus, by using a relevant animal model of polymicrobial sepsis, we studied the effect of vit B6 on the KYN pathway, acute neurochemical and neuroinflammatory parameters, and cognitive dysfunction in rats...
September 6, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28826225/low-oxidative-stress-mediated-proliferation-via-jnk-foxo3a-catalase-signaling-in-transplanted-adult-stem-cells-promotes-wound-tissue-regeneration
#3
Neha R Dhoke, Ramasatyaveni Geesala, Amitava Das
AIMS: Stem cells exposed to pathological levels of reactive oxygen species (ROS) at wound site fail to regenerate tissue. Molecular mechanism underlying differential levels of ROS-mediated regulation of stem cells remains elusive. This study elucidates mechanistic role of catalase at 10µM H<sub>2</sub>O<sub>2</sub>-induced proliferation of mouse bone marrow stromal (BMSC) and hematopoietic (HSPC) stem/progenitor cells. RESULTS: BMSCs and HSPCs depicted an increased growth rate and colony formation, in presence of 10µM but not 100µM concentration of H<sub>2</sub>O<sub>2</sub>, an effect that was perturbed by Vit...
August 21, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28815782/influence-of-conjugated-linoleic-acids-and-vitamin-e-on-milk-fatty-acid-composition-and-concentrations-of-vitamin-a-and-%C3%AE-tocopherol-in-blood-and-milk-of-dairy-cows
#4
S Schäfers, U Meyer, D von Soosten, L Hüther, C Drong, K Eder, E Most, A Tröscher, W Pelletier, A Zeyner, S Dänicke
The objective of this trial was to investigate the influences of conjugated linoleic acid (CLA) and vitamin E (Vit. E) and their interactions on fatty acid composition and vitamins in milk (α-tocopherol, retinol and β-carotene) as well as on α-tocopherol in blood of pluriparous cows from week 6 ante partum until week 10 post-partum (p.p.). We assigned 59 pluriparous German Holstein cows to four treatment groups with the treatment factors CLA and Vit. E at two levels in a 2 × 2 factorial design. Milk fatty acid composition and milk vitamins were analysed on lactation days 7 and 28...
August 16, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28805603/modern-human-sperm-freezing-effect-on-dna-chromatin-and-acrosome-integrity
#5
Tahereh Rahiminia, Akram Hosseini, Morteza Anvari, Saeed Ghasemi-Esmailabad, Ali Reza Talebi
OBJECTIVE: Presence of vitrification method in sperm freezing and the introduction of solid surface vitrification beside rapid freezing in vapour, opens an easy and safe way to help infertility centres. While the effects of cryopreservation on motility, morphology and viability of sperm are documented, the question of the probable alteration of sperm DNA, chromatin and acrosome integrity after freezing and thawing procedures in different methods is still controversial. MATERIALS AND METHODS: Normal sample were collected according to WHO strict criteria...
August 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28759296/potential-role-of-l-arginine-and-vitamin-e-against-bone-loss-induced-by-nano-zinc-oxide-in-rats
#6
Hala M Abdelkarem, Laila H Fadda, Eman M El-Sayed, Omyma K Radwan
The purpose of this study was to illustrate the effects of zinc oxide nanoparticles (ZnO-NPs) administration on bone turnover and bone resorbing agents in rats and how L-arginine (L-arg) or vitamin E (vit E) co-administrations might affect them. Fasting rats were randomly divided into four groups (n = 10): G1-normal healthy animals; G2-ZnO-NPs-exposed rats (600 mg/kg(-)1/day(-1)); G3-ZnO-NPs-exposed rats co-administrated L-arg (200 mg/kg(-)1/day(-1)); G4-ZnO-NPs-exposed rats co-administrated vit E (200 mg/kg(-)1/day(-1))...
July 31, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28737734/storage-of-fruits-and-vegetables-in-refrigerator-increases-their-phenolic-acids-but-decreases-the-total-phenolics-anthocyanins-and-vitamin-c-with-subsequent-loss-of-their-antioxidant-capacity
#7
Joseph H Y Galani, Jalpesh S Patel, Nilesh J Patel, Jayant G Talati
It is of paramount importance for consumers, scientists and industrialists to understand how low-temperature storage of food items affects their bioactive compounds and properties. This study evaluated the effects of cold storage on total phenolics (TP), phenolic acids profile (PA), total anthocyanins (TA), total ascorbic acid (Vit. C) and antioxidant activity (AA) of 19 fruits and vegetables, collected from local Indian markets and stored in refrigerator (4 °C) during 15 days. Content of TP was highest in dill and amaranth and decreased (up to 29...
July 24, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28734827/multi-omics-analyses-of-starvation-responses-reveal-a-central-role-for-lipoprotein-metabolism-in-acute-starvation-survival-in-c-%C3%A2-elegans
#8
Eva Bang Harvald, Richard R Sprenger, Kathrine Brændgaard Dall, Christer S Ejsing, Ronni Nielsen, Susanne Mandrup, Alejandro Brenes Murillo, Mark Larance, Anton Gartner, Angus I Lamond, Nils J Færgeman
Starvation causes comprehensive metabolic changes, which are still not fully understood. Here, we used quantitative proteomics and RNA sequencing to examine the temporal starvation responses in wild-type Caenorhabditis elegans and animals lacking the transcription factor HLH-30. Our findings show that starvation alters the abundance of hundreds of proteins and mRNAs in a temporal manner, many of which are involved in central metabolic pathways, including lipoprotein metabolism. We demonstrate that premature death of hlh-30 animals under starvation can be prevented by knockdown of either vit-1 or vit-5, encoding two different lipoproteins...
July 26, 2017: Cell Systems
https://www.readbyqxmd.com/read/28710069/vitamin-c-mitigates-oxidative-nitrosative-stress-and-inflammation-in-doxorubicin-induced-cardiomyopathy
#9
Gauri Akolkar, Danielle da Silva Dias, Prathapan Ayyappan, Ashim K Bagchi, Davinder S Jassal, Vera Mc Salemi, Maria Claudia Irigoyen, Katia De Angelis, Pawan K Singal
Increase in oxidative/nitrosative stress is one of the mechanisms associated with the development of cardiotoxicity due to Doxorubicin (Dox), a potent chemotherapy drug. Previously, we reported mitigation of Dox-induced oxidative/nitrosative stress and apoptosis by Vitamin C (Vit C) in isolated cardiomyocytes. In the present in vivo study in rats, we investigated the effect of prophylactic treatment with Vit C on Dox-induced apoptosis, inflammation, oxidative/nitrosative stress, cardiac dysfunction and Vit C transporter proteins...
July 14, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28687456/increased-oxidative-stress-and-deficient-antioxidant-levels-may-be-involved-in-the-pathogenesis-of-idiopathic-recurrent-acute-pancreatitis
#10
Sawan Bopanna, Baibaswat Nayak, Shyam Prakash, Shalimar, Soumya Jagannath Mahapatra, Pramod Kumar Garg
BACKGROUND: Increased Oxidative Stress (OS) is implicated in the pathogenesis of Chronic Pancreatitis (CP). Whether or not OS contributes to disease progression through the stages of Recurrent Acute Pancreatitis(RAP), to CP is not known. Increased OS, if present in RAP could be an important therapeutic target in preventing progression of RAP to CP. OBJECTIVE: To assess the oxidative stress and antioxidant status in patients with idiopathic RAP. METHODS: 50 consecutive patients with Idiopathic Recurrent Acute Pancreatitis (IRAP) were included...
July 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28678856/time-course-of-changes-in-oxidative-stress-and-stress-induced-proteins-in-cardiomyocytes-exposed-to-doxorubicin-and-prevention-by-vitamin-c
#11
Ana Ludke, Gauri Akolkar, Prathapan Ayyappan, Anita K Sharma, Pawan K Singal
We previously reported that Vitamin C (Vit C) protects against doxorubicin (Dox)-induced cardiotoxicity by reducing oxidative stress, p38 mitogen-activated kinase (MAPK) and p53 activation and rescuing cell death in isolated adult cardiomyocytes. The pattern of activation and the role of oxidative stress as well as down-stream mechanisms for such protection remain elusive. Therefore the present study aims to analyze time-dependant generation of reactive oxygen species (ROS) and the activation of stress induced signalling pathways in cardiomyocytes treated with Dox and Vit C...
2017: PloS One
https://www.readbyqxmd.com/read/28658959/vitamin-c-attenuates-methotrexate-induced-oxidative-stress-in-kidney-and-liver-of-rats
#12
M Savran, E Cicek, D K Doguc, H Asci, S Yesilot, I A Candan, B Dagdeviren, F N Cankara, M Oncu, A C Uğuz, M K Ozer
Like several other anticancer drugs, methotrexate (MTX) causes side effects, such as neuropathic pain, hepatotoxicity, and nephrotoxicity. Abnormal production of reactive oxygen species has been suspected in the pathophysiology of MTX-induced hepatorenal toxicity. Therefore, the aim of this study was to investigate the probable protective role of vitamin C (Vit C) on oxidative stress induced by MTX in the liver and kidney tissues of rats. A total of 32 rats were randomly and equally divided into four groups...
June 29, 2017: Physiology International
https://www.readbyqxmd.com/read/28654017/does-vitamin-c-influence-neurodegenerative-diseases-and-psychiatric-disorders
#13
REVIEW
Joanna Kocot, Dorota Luchowska-Kocot, Małgorzata Kiełczykowska, Irena Musik, Jacek Kurzepa
Vitamin C (Vit C) is considered to be a vital antioxidant molecule in the brain. Intracellular Vit C helps maintain integrity and function of several processes in the central nervous system (CNS), including neuronal maturation and differentiation, myelin formation, synthesis of catecholamine, modulation of neurotransmission and antioxidant protection. The importance of Vit C for CNS function has been proven by the fact that targeted deletion of the sodium-vitamin C co-transporter in mice results in widespread cerebral hemorrhage and death on post-natal day one...
June 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28638434/an-evaluation-of-the-protective-role-of-vitamin-c-in-reactive-oxygen-species-induced-hepatotoxicity-due-to-hexavalent-chromium-in-vitro-and-in-vivo
#14
Xiali Zhong, Ming Zeng, Huanfeng Bian, Caigao Zhong, Fang Xiao
BACKGROUD: Drinking water contamination with hexavalent chromium [Cr (VI)] has become one of the most serious public health problems, thus the investigation of Cr (VI)-induced hepatotoxicity has attracted much attention in recent years. METHODS: In the present study, by determining the indices of hepatotoxicity induced by Cr (VI), the source of accumulated reactive oxygen species (ROS), and the protective effect of the antioxidant Vitamin C (Vit C), we explored the mechanisms involved in Cr (VI)-induced hepatotoxicity in vitro and in vivo...
2017: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/28604251/the-effect-of-a-vegetarian-vs-conventional-hypocaloric-diabetic-diet-on-thigh-adipose-tissue-distribution-in-subjects-with-type-2-diabetes-a-randomized-study
#15
Hana Kahleova, Marta Klementova, Vit Herynek, Antonin Skoch, Stepan Herynek, Martin Hill, Andrea Mari, Terezie Pelikanova
OBJECTIVE: The aim of our study was to compare the effects of a vegetarian and a conventional diet on thigh adipose tissue distribution in subjects with type 2 diabetes (T2D). METHODS: Seventy-four subjects with T2D were randomly assigned to either follow a vegetarian diet (V, n = 37) or a control group who followed an isocaloric conventional anti-diabetic diet (C, n = 37). Both diets were calorie restricted (-500 kcal/day). To measure insulin sensitivity, the hyperinsulinemic (1 mU...
July 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28580333/oral-administration-of-vitamin-c-cimetidine-and-famotidine-on-micronuclei-induced-by-low-dose-radiation-in-mouse-bone-marrow-cells
#16
A Naeeji, H Mozdarani, A Shabestani Monfared, F Faeghi, A A Ahmadi, M Gholami, R Behzadi, M R Momtaz
BACKGROUND: In many studies, chemicals and natural materials were tested to reduce the harmful effects of radiation. It is known that Famotidine and vitamin C reduce DNA damage. OBJECTIVE: The aim of this study was to evaluate the radioprotective effect of vitamin C, Cimetidine and Famotidine on gamma-radiation-induced damage on mouse bone marrow. METHODS: Six-to-seven week male NMRI mice (28 g ±3) were randomly divided into fourteen groups: control, 2Gy irradiation, six group drugs without irradition (Famotidine, Cimetidine, vitaminC, Fam-Cim, Fam-Vit, Cim-Vit), six groups received drugs and 2Gy radiation with a 60Co |γ|-ray source at room temperature 22 ± 2 °C...
June 2017: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/28557561/in-vivo-anti-inflammatory-activity-of-aqueous-extract-of-teucrium-polium-against-carrageenan-induced-inflammation-in-experimental-models
#17
Fatma Rahmouni, Latifa Hamdaoui, Tarek Rebai
The aim of this study was to evaluate the anti-inflammatory activity of Teucrium polium (TP). Rats were divided into four groups: group 1 controls received standard diet; group 2 inflamed by carrageenan (Carr) (1% Carr); group 3 as reference inflamed with Carr and treated with Indometacine (Ind) (150 mg/kg bw) and group 4 inflamed with Carr and pre0treated with TP (5 g/L). Oedema volume was measured 1 h to 5 h after injection. Administration of TP or Ind decreased the levels of hematology parameters relative to Carr and reduced the volume of rats induced by Carr...
May 30, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28489936/the-association-of-dietary-vitamin-c-intake-with-periodontitis-among-korean-adults-results-from-knhanes-%C3%A2
#18
Jung-Hoo Lee, Myung-Seop Shin, Eun-Jeong Kim, Yoo-Been Ahn, Hyun-Duck Kim
BACKGROUNDS: The association of dietary vitamin C (vit C) on periodontitis requires more valid evidence from large representative samples to enable sufficient adjustments. This study aimed to evaluate the association between dietary vit C intake and periodontitis after controlling for various confounders in the representative Korean adult population. METHOD: A total of 10,930 Korean adults (≥19 years) from the fourth Korean National Health and Nutrition Examination Survey data set were included in this cross-sectional study...
2017: PloS One
https://www.readbyqxmd.com/read/28451526/vitamin-c-and-vitamin-e-protected-b95-8-and-balb-c-3t3-cells-from-apoptosis-induced-by-intermittent-50hz-elf-emf-radiation
#19
Zhen Ding, Jintao Li, Fan Li, Mohammadreza Mohammadzad Mephryar, Shuicai Wu, Chen Zhang, Yi Zeng
BACKGROUND: The extremely low-frequency electromagnetic field (ELF-EMF), mainly emitted by electric transmission lines and household electronic appliances, is becoming a worldwide health risk. It is imperative to investigate the biological impacts of ELF-EMF and to identify products that are resistant to the radiation from 50 Hz ELF-EMF. In this study, we investigated the biological impacts of apoptosis caused by 50 Hz Power line ELF-EMF and the protective effects of Vit C and Vit E. METHODS: We conducted this study in Beijing, China in 2013...
January 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28448868/protective-effects-of-teucrium-polium-aqueous-extract-and-ascorbic-acid-on-hematological-and-some-biochemical-parameters-against-carbon-tetrachloride-ccl4-induced-toxicity-in-rats
#20
Fatma Rahmouni, Latifa Hamdaoui, Riadh Badraoui, Tarek Rebai
Herbal drugs play a crucial function to protect organisms from the toxic effect of some compounds. The present study was designed to evaluate the protective effects of Teucrium Polium (TP) aqueous extract and vitamin C (Vit C) against carbon tetrachloride (CCl4) which induced toxicity in rats. Male albino Wistar rats were divided into six groups: group I was used as controls, group II received CCl4 in olive oil (0.5ml/kg) by gavage, and group III received CCl4 in olive oil (0.5ml/kg) by gavage after three days of receiving TP (5g/l), orally, for seven days; Group IV received TP (5g/l) alone, orally, for seven days, Group V received CCl4 in olive oil (0...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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