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Vit C

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https://www.readbyqxmd.com/read/28225575/25-hydroxy-vitamin-d-suppresses-hepatitis-c-virus-replication-and-contributes-to-rapid-virological-response-of-treatment-efficacy
#1
Jee-Fu Huang, Yu-Min Ko, Chung-Feng Huang, Ming-Lun Yeh, Chia-Yen Dai, Meng-Hsuan Hsieh, Ching-I Huang, Hua-Ling Yang, Shu-Chi Wang, Zu-Yau Lin, Shinn-Chern Chen, Ming-Lung Yu, Wan-Long Chuang
AIM: 25-hydroxy vitamin D (Vit D) plays a role in treatment outcomes in chronic hepatitis C virus (HCV) infection (CHC). We aimed to clarify HCV replication is inhibited by Vit D in HCV replicon cells. Clinical implication was assessed for rapid virological response (RVR) and sustained virological response (SVR) among those patients receiving anti-viral therapy. METHODS: Cell survival and viral loads were observed in Con1 (genotype-1b) and J6/JFH (genotype-2a) cells treated with different doses of Vit D...
February 22, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28213641/role-of-levothyroxine-and-vitamin-e-supplementation-in-the-treatment-of-oxidative-stress-induced-injury-and-apoptosis-of-myocardial-cells-in-hypothyroid-rats
#2
J Ye, X Zhong, Y Du, C Cai, T Pan
OBJECTIVE: To explore the underlying mechanism and treatment of myocardial injury caused by hypothyroidism, we evaluated oxidative stress in serum and myocardial tissue of hypothyroid rats. The effect of levothyroxine (LT4) replacement therapy and vitamin E (VitE) supplementation on oxidative stress-induced injury and apoptosis of myocardial tissue is examined. METHODS: Male Sprague-Dawley rats were divided into five groups: normal control group, propylthiouracil group (PTU group), LT4 treatment group (PTU + LT4 group), vitamin E treatment group (PTU + VitE group), and combined treatment group (PTU + LT4 + VitE group)...
February 17, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28210072/the-parenteral-vitamin-c-improves-sepsis-and-sepsis-induced-multiple-organ-dysfunction-syndrome-via-preventing-cellular-immunosuppression
#3
Yu-Lei Gao, Bin Lu, Jian-Hua Zhai, Yan-Cun Liu, Hai-Xia Qi, Ying Yao, Yan-Fen Chai, Song-Tao Shou
Cellular immunosuppression appears to be involved in sepsis and sepsis-induced multiple organ dysfunction syndrome (MODS). Recent evidence showed that parenteral vitamin C (Vit C) had the ability to attenuate sepsis and sepsis-induced MODS. Herein, we investigated the impact of parenteral Vit C on cellular immunosuppression and the therapeutic value in sepsis. Using cecal ligation and puncture (CLP), sepsis was induced in WT and Gulo(-/-) mice followed with 200 mg/Kg parenteral Vit C administration. The immunologic functions of CD4(+)CD25(+) regulatory T cells (Tregs) and CD4(+)CD25(-) T cells, as well as the organ functions, were determined...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28178330/comparative-study-of-extrapolative-factors-linked-with-oxidative-injury-and-anti-inflammatory-status-in-chronic-kidney-disease-patients-experiencing-cardiovascular-distress
#4
Mahmood Rasool, Muhammad Abdul Basit Ashraf, Arif Malik, Sulayman Waquar, Shahida Aziz Khan, Mahmood Husain Qazi, Waseem Ahmad, Muhammad Asif, Sami Ullah Khan, Ahmad Zaheer, Muther Mansoor Qaisrani, Abdul Rehman Khan, Aamir Iqbal, Amir Raza, Saima Iram, Kashif Kamran, Asim Iqbal, Mohammad Zahid Mustafa, Hani Choudhry, Mazin A Zamzami, Wesam H Abdulaal, Mohammad Sarwar Jamal
BACKGROUND: Chronic kidney disease (CKD) is a group of heterogeneous abnormalities affecting the function and structure of the kidney and mostly further proceeds to cardiovascular damage prior to end stage renal disease (ESRD). The oxidative insult and inflammatory mediators have some undefined role in CKD and cardiovascular complications. It is therefore, aimed at to pin point the predictive factors in the development of cardiovascular disorder in patients with chronic kidney disease...
2017: PloS One
https://www.readbyqxmd.com/read/28169974/f-calprotectin-and-blood-markers-correlate-to-quality-of-life-in-pediatric-inflammatory-bowel-disease
#5
Katrine Carlsen, Christian Jakobsen, Thomas Kallemose, Anders Paerregaard, Lene Buhl Riis, Pia Munkholm, Vibeke Wewer
OBJECTIVES: Our aim was to investigate predictors of Health Related Quality of Life (HRQoL) with respect to changes in disease parameters over time in children with Inflammatory Bowel Disease (IBD). METHODS: This was a prospective longitudinal study examining the association between HRQoL (IMPACT III) and symptom scores (PCDAI, abbrPUCAI), fecal calprotectin (FC) measures and blood analyses (C-reactive protein [CRP], erythrocyte sedimentation-rate [ESR], orosomucoid [ORM], albumin [ALB], hemoglobin [HB] and vitamin-D [VIT-D]) in a cohort of 10-17 years old IBD patients...
February 4, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28127705/the-effects-of-vitamin-c-on-hypothyroidism-associated-learning-and-memory-impairment-in-juvenile-rats
#6
Farimah Beheshti, Sareh Karimi, Farzaneh Vafaee, Mohammad Naser Shafei, Hamid Reza Sadeghnia, Mosa Al Reza Hadjzadeh, Mahmoud Hosseini
In this study the effects of Vitamin C (Vit C) on hypothyroidism-associated learning and memory impairment in juvenile rats was investigated. The pregnant rats were kept in separate cages. After delivery, they were randomly divided into six groups and treated: (1) Control; (2) Propylthiouracil (PTU) which 0.005% PTU in their drinking; (3-5) Propylthiouracil- Vit C groups; besides PTU, dams in these groups received 10, 100 and 500 mg/kg Vit C respectively, (6) one group as a positive control; the intact rats received an effective dose, 100 mg/kg Vit...
January 26, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28120601/hymenoptera-venom-allergy-a-closer-collaboration-is-needed-between-allergists-and-emergency-physicians
#7
A Ciccarelli, C Calabrò, C Imperatore, G Scala
Background. Hymenoptera stings are sometimes fatal in venom-allergic patients. Fatalities mostly occur in previously stung subjects, especially those with a history of systemic reactions, and could be avoided if patients were properly informed of the existence of a prevention strategy for insect stings, referred to an allergy follow-up and prescribed auto-injectable epinephrine and/or venom-specific immunotherapy (VIT). We sought to assess knowledge and awareness of Hymenoptera Venom Allergy (HVA) in a small sample of Emergency Physicians in our geographic area...
January 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28120424/allergen-immunotherapy-for-insect-venom-allergy-a-systematic-review-and-meta-analysis
#8
REVIEW
S Dhami, H Zaman, E-M Varga, G J Sturm, A Muraro, C A Akdis, D Antolín-Amérigo, M B Bilò, D Bokanovic, M A Calderon, E Cichocka-Jarosz, J N G Oude Elberink, R Gawlik, T Jakob, M Kosnik, J Lange, E Mingomataj, D I Mitsias, H Mosbech, M Ollert, O Pfaar, C Pitsios, V Pravettoni, G Roberts, F Ruëff, B A Sin, M Asaria, G Netuveli, A Sheikh
BACKGROUND: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines on Allergen Immunotherapy (AIT) for the management of insect venom allergy. To inform this process, we sought to assess the effectiveness, cost-effectiveness and safety of AIT in the management of insect venom allergy. METHODS: We undertook a systematic review, which involved searching 15 international biomedical databases for published and unpublished evidence...
November 6, 2016: Allergy
https://www.readbyqxmd.com/read/28100487/doxorubicin-induced-nitrosative-stress-is-mitigated-by-vitamin-c-via-the-modulation-of-nitric-oxide-synthases
#9
Gauri Akolkar, Ashim K Bagchi, Prathapan Ayyappan, Davinder S Jassal, Pawan K Singal
An increase in oxidative stress is suggested to be the main cause in Doxorubicin (Dox) -induced cardiotoxicity. However, there is now evidence that activation of inducible nitric oxide synthase (iNOS) and nitrosative stress are also involved. The role of Vitamin C (Vit C) in the regulation of nitric oxide synthase (NOS) and reduction of nitrosative stress in Dox-induced cardiotoxicity is unknown. The present study investigated the effects of Vit C in the mitigation of Dox-induced changes in the levels of nitric oxide (NO), NOS activity, protein expression of NOS isoforms and nitrosative stress as well as cytokines TNFα and IL-10 in isolated cardiomyocytes...
January 18, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/27996943/insect-venom-immunotherapy-analysis-of-the-safety-and-tolerance-of-3-buildup-protocols-frequently-used-in-spain
#10
D Gutiérrez Fernández, A Moreno-Ancillo, S Fernández Meléndez, C Domínguez-Noche, P Gálvez Ruiz, T Alfaya Arias
INTRODUCTION: Hymenoptera venom immunotherapy (VIT) is an effective treatment but not one devoid of risk, as both local and systemic adverse reactions may occur, especially in the initial phases. We compared the tolerance to 3 VIT buildup protocols and analyzed risk factors associated with adverse reactions during this phase. MATERIALS AND METHODS: We enrolled 165 patients divided into 3 groups based on the buildup protocol used (3, 4, and 9 weeks). The severity of systemic reactions was evaluated according to the World Allergy Organization model...
2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27925387/microcomputed-tomography-evaluation-of-volumetric-shrinkage-of-bulk-fill-composites-in-class-ii-cavities
#11
Hamad Algamaiah, Camila S Sampaio, Lindiane C Rigo, Malvin N Janal, Marcelo Giannini, Estevam A Bonfante, Paulo G Coelho, Andre F Reis, Ronaldo Hirata
PURPOSE: This study aimed to quantify polymerization shrinkage of one conventional and three bulk-fill composites, under bonded and unbonded conditions, in Class II preparations using 3D microcomputed tomography (μCT) and report its location. MATERIALS AND METHODS: Preparations (2.5 mm occlusal depth × 4 mm wide × 4 mm mesial box and 1 mm beyond the CEJ distal box depth) were made in 48 human extracted molars (n = 6). Four composites were tested, one regular (Vitalescence/VIT) and three bulk-fill: SureFil SDR Flow (SDR), Tetric EvoCeram Bulk Fill (TET), and Filtek flowable Bulk Fill (FIL)...
December 7, 2016: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/27920821/protective-effect-of-vitamin-c-vitamin-b12-and-omega-3-on-lead-induced-memory-impairment-in-rat
#12
Saeedeh Alsadat Moosavirad, Mohammad Rabbani, Mohammad Sharifzadeh, Ali Hosseini-Sharifabad
Lead belongs to the heavy metal group and is considered as an environmental contaminant. Acute or chronic contact to lead can change the physiological function of human organs. One of the most important disorders following the lead exposure is neurotoxicity. Lead neurotoxicity consists of the neurobehavioral disturbances like cognitive impairment. The aim of the current study is to evaluate the possible protective effect of vitamin C (Vit C), vitamin B12 (Vit B12), omega 3 (ω-3), or their combination on the lead-induced memory disorder...
October 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27903510/vitamin-d-supplementation-reduces-some-at1-aa-induced-downstream-targets-implicated-in-preeclampsia-including-hypertension
#13
Jessica L Faulkner, Lorena M Amaral, Denise C Cornelius, Mark W Cunningham, Tarek Ibrahim, Autumn Heep, Nathan Campbell, Nathan Usry, Kedra Wallace, Florian Herse, Ralf Dechend, Babbette LaMarca
Autoantibodies to the ANG II type I receptor (AT1-AA) are associated with preeclampsia (PE). We found that vitamin D supplementation reduced AT1-AA and blood pressure (MAP) in the RUPP rat model of PE. However, it was undetermined whether the decrease in AT1-AA was the mechanism whereby vitamin D lowered MAP or if it were through factors downstream of AT1-AA. Uterine artery resistance index, placental ET-1, and soluble FMS-like tyrosine kinase-1 are increased with AT1-AA-induced hypertension and are considered markers of PE in pregnant women...
January 1, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27713770/the-role-of-vitamin-d-in-immuno-inflammatory-responses-in-ankylosing-spondylitis-patients-with-and-without-acute-anterior-uveitis
#14
EDITORIAL
T C Mitulescu, C Stavaru, L M Voinea, L M Banica, C Matache, D Predeteanu
Hypothesis:Abnormal Vitamin D (Vit D) level could have consequences on the immuno-inflammatory processes in Ankylosing Spondylitis (AS). Aim:The purpose of this study was to analyze the role of Vitamin D in the interplay between immune and inflammation effectors in AS associated-Acute Anterior Uveitis (AAU). Methods and Results:25-hydroxyvitamin D (Vit D), LL-37 peptide, IL-8 and Serum Amyloid A (SAA) were identified and quantified in the serum/ plasma of thirty-four AS patients [eleven AS patients presenting AAU (AAU AS patients) and twenty-three AS patients without AAU (wAAU AS patients)] and eighteen healthy individuals (Control) using enzyme-linked immunosorbent assay...
January 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27690005/oral-supplementation-with-a-special-additive-of-retinyl-palmitate-and-alpha-tocopherol-reduces-growth-retardation-in-young-pancreatic-duct-ligated-pigs-used-as-a-model-for-children-suffering-from-exocrine-pancreatic-insufficiency
#15
Anne Mößeler, Marion Schmicke, Martin Höltershinken, Martin Beyerbach, Josef Kamphues
Pancreatic exocrine insufficiency (PEI) is a disease of diverse aetiology-e.g., majority of patients suffering from cystic fibrosis (CF) show PEI congenitally. Malnutrition and malabsorption of nutrients impair growth and nutritional status. As reduced fat digestion leads to a deficiency of fat-soluble vitamins the supplementation is standard, but absorption is a critical point in PEI-patients. The pancreatic duct ligated (PL) pig is an established model for PEI in humans and has been proven to be a suitable model to compare different vitamin additives for supplementation...
September 28, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27658741/human-tolerogenic-dendritic-cells-generated-with-protein-kinase-c-inhibitor-are-optimal-for-functional-regulatory-t-cell-induction-a-comparative-study
#16
Endy Adnan, Takuya Matsumoto, Jun Ishizaki, Sachiko Onishi, Koichiro Suemori, Masaki Yasukawa, Hitoshi Hasegawa
Tolerogenic dendritic cells (tDCs) are a promising therapeutic tool for specific induction of immunological tolerance. Human tDCs can be generated ex vivo using various compounds. However, the compound(s) most suitable for clinical application remain undefined. We compared the tolerogenic properties of tDCs treated with protein kinase C inhibitor (PKCI), dexamethasone, vitamin D3 (Vit D3), rapamycin (Rapa), interleukin (IL)-10, transforming growth factor (TGF)-β, and a combination of peroxisome proliferator-activated receptor γ agonist and retinoic acid...
December 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27621606/a-preliminary-study-on-the-effects-of-star-fruit-consumption-on-antioxidant-and-lipid-status-in-elderly-thai-individuals
#17
Jirakrit Leelarungrayub, Araya Yankai, Decha Pinkaew, Rungthip Puntumetakul, James J Laskin, Richard J Bloomer
OBJECTIVE: The aims of this preliminary study were to evaluate the antioxidant and lipid status before and after star fruit juice consumption in healthy elderly subjects, and the vitamins in star fruit extracts. METHODS: A preliminary designated protocol was performed in 27 elderly individuals with a mean (±SD) age of 69.5±5.3 years, by planning a 2-week control period before 4 weeks of consumption of star fruit twice daily. Oxidative stress parameters such as total antioxidant capacity, glutathione, malondialdehyde, protein hydroperoxide, multivitamins such as l-ascorbic acid (Vit C), retinoic acid (Vit A), and tocopherol (Vit E), and the lipid profile parameters such as cholesterol, triglyceride, high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) were analyzed...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27620743/proteomic-analysis-of-the-vitamin-c-effect-on-the-doxorubicin-cytotoxicity-in-the-mcf-7-breast-cancer-cell-line
#18
Peter Bober, Michal Alexovic, Ivan Talian, Zuzana Tomkova, Zuzana Viscorova, Maria Benckova, Igor Andrasina, Rachele Ciccocioppo, Daniel Petrovic, Mariusz Adamek, Peter Kruzliak, Jan Sabo
PURPOSE: Doxorubicin is an anthracycline drug which inhibits the growth of breast cancer cell lines. However, a major factor limiting its use is a cumulative, dose-dependent cardiotoxicity, resulting in a permanent loss of cardiomyocytes. Vitamin C was found to potentiate the cytotoxic effects of a variety of chemotherapeutic drugs including doxorubicin. The aim of the study was to describe the changes in protein expression and proliferation of the MCF-7 cells induced by the vitamin C applied with doxorubicin...
January 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27574411/plasma-homocysteine-level-is-a-risk-factor-for-osteoporotic-fractures-in-elderly-patients
#19
Yuefeng Zhu, Jie Shen, Qun Cheng, Yongqian Fan, Weilong Lin
OBJECTIVE: To study the relationship of plasma homocysteine (Hcy), bone turnover biomarkers (BTB), and bone mineral density (BMD) with osteoporotic fracture (OPF) in elderly people. METHODS: Eighty-two patients (aged 65 years or older) admitted to our orthopedics department between October 2014 and May 2015 were randomly divided into three groups: 1) OPF group: 39 cases with the mean age 81.82±5.49 years, which included 24 females and 15 males; 2) high-energy fracture (HEF) group: 22 cases with the mean age 78...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27540292/using-ferromagnetic-nanoparticles-with-low-curie-temperature-for-magnetic-resonance-imaging-guided-thermoablation
#20
Vít Herynek, Karolína Turnovcová, Pavel Veverka, Tereza Dědourková, Pavel Žvátora, Pavla Jendelová, Andrea Gálisová, Lucie Kosinová, Klára Jiráková, Eva Syková
INTRODUCTION: Magnetic nanoparticles (NPs) represent a tool for use in magnetic resonance imaging (MRI)-guided thermoablation of tumors using an external high-frequency (HF) magnetic field. To avoid local overheating, perovskite NPs with a lower Curie temperature (T c) were proposed for use in thermotherapy. However, deposited power decreases when approaching the Curie temperature and consequently may not be sufficient for effective ablation. The goal of the study was to test this hypothesis...
2016: International Journal of Nanomedicine
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