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https://www.readbyqxmd.com/read/28638434/an-evaluation-of-the-protective-role-of-vitamin-c-in-reactive-oxygen-species-induced-hepatotoxicity-due-to-hexavalent-chromium-in-vitro-and-in-vivo
#1
Xiali Zhong, Ming Zeng, Huanfeng Bian, Caigao Zhong, Fang Xiao
BACKGROUD: Drinking water contamination with hexavalent chromium [Cr (VI)] has become one of the most serious public health problems, thus the investigation of Cr (VI)-induced hepatotoxicity has attracted much attention in recent years. METHODS: In the present study, by determining the indices of hepatotoxicity induced by Cr (VI), the source of accumulated reactive oxygen species (ROS), and the protective effect of the antioxidant Vitamin C (Vit C), we explored the mechanisms involved in Cr (VI)-induced hepatotoxicity in vitro and in vivo...
2017: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/28604251/the-effect-of-a-vegetarian-vs-conventional-hypocaloric-diabetic-diet-on-thigh-adipose-tissue-distribution-in-subjects-with-type-2-diabetes-a-randomized-study
#2
Hana Kahleova, Marta Klementova, Vit Herynek, Antonin Skoch, Stepan Herynek, Martin Hill, Andrea Mari, Terezie Pelikanova
OBJECTIVE: The aim of our study was to compare the effects of a vegetarian and a conventional diet on thigh adipose tissue distribution in subjects with type 2 diabetes (T2D). METHODS: Seventy-four subjects with T2D were randomly assigned to either follow a vegetarian diet (V, n = 37) or a control group who followed an isocaloric conventional anti-diabetic diet (C, n = 37). Both diets were calorie restricted (-500 kcal/day). To measure insulin sensitivity, the hyperinsulinemic (1 mU...
June 10, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28580333/oral-administration-of-vitamin-c-cimetidine-and-famotidine-on-micronuclei-induced-by-low-dose-radiation-in-mouse-bone-marrow-cells
#3
A Naeeji, H Mozdarani, A Shabestani Monfared, F Faeghi, A A Ahmadi, M Gholami, R Behzadi, M R Momtaz
BACKGROUND: In many studies, chemicals and natural materials were tested to reduce the harmful effects of radiation. It is known that Famotidine and vitamin C reduce DNA damage. OBJECTIVE: The aim of this study was to evaluate the radioprotective effect of vitamin C, Cimetidine and Famotidine on gamma-radiation-induced damage on mouse bone marrow. METHODS: Six-to-seven week male NMRI mice (28 g ±3) were randomly divided into fourteen groups: control, 2Gy irradiation, six group drugs without irradition (Famotidine, Cimetidine, vitaminC, Fam-Cim, Fam-Vit, Cim-Vit), six groups received drugs and 2Gy radiation with a 60Co |γ|-ray source at room temperature 22 ± 2 °C...
June 2017: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/28557561/in-vivo-anti-inflammatory-activity-of-aqueous-extract-of-teucrium-polium-against-carrageenan-induced-inflammation-in-experimental-models
#4
Fatma Rahmouni, Latifa Hamdaoui, Tarek Rebai
The aim of this study was to evaluate the anti-inflammatory activity of Teucrium polium (TP). Rats were divided into four groups: group 1 controls received standard diet; group 2 inflamed by carrageenan (Carr) (1% Carr); group 3 as reference inflamed with Carr and treated with Indometacine (Ind) (150 mg/kg bw) and group 4 inflamed with Carr and pre0treated with TP (5 g/L). Oedema volume was measured 1 h to 5 h after injection. Administration of TP or Ind decreased the levels of hematology parameters relative to Carr and reduced the volume of rats induced by Carr...
May 30, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28489936/the-association-of-dietary-vitamin-c-intake-with-periodontitis-among-korean-adults-results-from-knhanes-%C3%A2
#5
Jung-Hoo Lee, Myung-Seop Shin, Eun-Jeong Kim, Yoo-Been Ahn, Hyun-Duck Kim
BACKGROUNDS: The association of dietary vitamin C (vit C) on periodontitis requires more valid evidence from large representative samples to enable sufficient adjustments. This study aimed to evaluate the association between dietary vit C intake and periodontitis after controlling for various confounders in the representative Korean adult population. METHOD: A total of 10,930 Korean adults (≥19 years) from the fourth Korean National Health and Nutrition Examination Survey data set were included in this cross-sectional study...
2017: PloS One
https://www.readbyqxmd.com/read/28451526/vitamin-c-and-vitamin-e-protected-b95-8-and-balb-c-3t3-cells-from-apoptosis-induced-by-intermittent-50hz-elf-emf-radiation
#6
Zhen Ding, Jintao Li, Fan Li, Mohammadreza Mohammadzad Mephryar, Shuicai Wu, Chen Zhang, Yi Zeng
BACKGROUND: The extremely low-frequency electromagnetic field (ELF-EMF), mainly emitted by electric transmission lines and household electronic appliances, is becoming a worldwide health risk. It is imperative to investigate the biological impacts of ELF-EMF and to identify products that are resistant to the radiation from 50 Hz ELF-EMF. In this study, we investigated the biological impacts of apoptosis caused by 50 Hz Power line ELF-EMF and the protective effects of Vit C and Vit E. METHODS: We conducted this study in Beijing, China in 2013...
January 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28448868/protective-effects-of-teucrium-polium-aqueous-extract-and-ascorbic-acid-on-hematological-and-some-biochemical-parameters-against-carbon-tetrachloride-ccl4-induced-toxicity-in-rats
#7
Fatma Rahmouni, Latifa Hamdaoui, Riadh Badraoui, Tarek Rebai
Herbal drugs play a crucial function to protect organisms from the toxic effect of some compounds. The present study was designed to evaluate the protective effects of Teucrium Polium (TP) aqueous extract and vitamin C (Vit C) against carbon tetrachloride (CCl4) which induced toxicity in rats. Male albino Wistar rats were divided into six groups: group I was used as controls, group II received CCl4 in olive oil (0.5ml/kg) by gavage, and group III received CCl4 in olive oil (0.5ml/kg) by gavage after three days of receiving TP (5g/l), orally, for seven days; Group IV received TP (5g/l) alone, orally, for seven days, Group V received CCl4 in olive oil (0...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28427291/antioxidant-therapy-for-management-of-oxidative-stress-induced-hypertension
#8
Khalil Ali Ahmad, Dai Yuan Yuan, Waqas Nawaz, Hong Ze, Chen Xue Zhuo, Bashar Talal, Abdoh Taleb, Enos Mais, Ding Qilong
Hypertension is considered as the most common risk factor for cardiovascular diseases, also is regarded as a leading cause of the mortality and morbidity worldwide. The mechanisms underlying the pathological process of hypertension are not completely explained. However, there is growing evidence that increased oxidative stress plays an important role in the pathophysiology of hypertension. Several preclinical studies and clinical trials have indicated that antioxidant therapy is important for management of hypertension, using antioxidants compounds such as alpha tocopherol (Vit E) and ascorbic acid (Vit C), polyphenols with others and some antihypertensive drugs that are now in clinical use (e...
May 9, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28369388/environmental-canalization-of-life-span-and-gene-expression-in-caenorhabditis-elegans
#9
Alexander Mendenhall, Matthew M Crane, Scott Leiser, George Sutphin, Patricia M Tedesco, Matt Kaeberlein, Thomas E Johnson, Roger Brent
Animals, particularly poikilotherms, exhibit distinct physiologies at different environmental temperatures. Here, we hypothesized that temperature-based differences in physiology could affect the amount of variation in complex quantitative traits. Specifically, we examined, in Caenorhabditis elegans, how different temperatures (15°C, 20°C, and 25°C) affected the amount of interindividual variation in life span and also expression of three reporter genes-transcriptional reporters for vit-2, gpd-2, and hsp-16...
February 22, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28343910/anti-skin-aging-effect-of-epigallocatechin-gallate-by-regulating-epidermal-growth-factor-receptor-pathway-on-aging-mouse-model-induced-by-d-galactose
#10
Jiming Chen, Yifan Li, Qiangqiang Zhu, Tong Li, Hao Lu, Nan Wei, Yewei Huang, Ruoyu Shi, Xiao Ma, Xuanjun Wang, Jun Sheng
Epigallocatechin gallate(EGCG) is a monomer separated from tea catechins, as an well-known antioxidant, which helps fight wrinkles and rejuvenate skin cells. In this study, we investigated the anti-aging effect of EGCG, and to clarify underlying mechanism of skin aging in a d-galactose-induced aging mouse model. Forty-five male mice were divided into 5 groups and treated with different dose of EGCG, Vitamin C (VitC) to mice as a positive control. All groups except vehicle were established aging model induced by d-galactose (200mg/kg/day) that was subcutaneously injected to mice for 8 weeks...
March 24, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28335738/genome-wide-expression-profiling-establishes-novel-modulatory-roles-of-vitamin-c-in-thp-1-human-monocytic-cell-line
#11
Sakshi Dhingra Batra, Malobi Nandi, Kriti Sikri, Jaya Sivaswami Tyagi
BACKGROUND: Vitamin C (vit C) is an essential dietary nutrient, which is a potent antioxidant, a free radical scavenger and functions as a cofactor in many enzymatic reactions. Vit C is also considered to enhance the immune effector function of macrophages, which are regarded to be the first line of defence in response to any pathogen. The THP-1 cell line is widely used for studying macrophage functions and for analyzing host cell-pathogen interactions. RESULTS: We performed a genome-wide temporal gene expression and functional enrichment analysis of THP-1 cells treated with 100 μM of vit C, a physiologically relevant concentration of the vitamin...
March 23, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28322549/vitamin-c-modulates-the-immunotoxic-effect-of-17%C3%AE-methyltestosterone-in-nile-tilapia
#12
Haitham G Abo-Al-Ela, Abeer F El-Nahas, Shawky Mahmoud, Essam M Ibrahim
The synthetic androgen 17α-methyltestosterone (MT) is profusely used and practically needed in the production of all-male Nile tilapia fry; however, such androgenic hormones badly disrupt the immune system. This study aimed to alleviate or counteract the immunotoxic effect of MT using vitamin C (ascorbic acid or vit C). Our results show that the highest phagocytic activity (PA), phagocytic index (PI), and lysozyme activity were detected in the vit C group and the MT plus vit C group. Furthermore, PA and PI were significantly suppressed, but lysozyme activity was stronger in the MT group than in the control...
April 11, 2017: Biochemistry
https://www.readbyqxmd.com/read/28276446/systemic-injection-of-aav9-gdnf-provides-modest-functional-improvements-in-the-sod1-g93a-als-rat-but-has-adverse-side-effects
#13
G M Thomsen, M Alkaslasi, J-P Vit, G Lawless, M Godoy, G Gowing, O Shelest, C N Svendsen
Injecting proteins into the central nervous system that stimulate neuronal growth can lead to beneficial effects in animal models of disease. In particular, glial cell line-derived neurotrophic factor (GDNF) has shown promise in animal and cell models of Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis (ALS). Here, systemic AAV9-GDNF was delivered via tail vein injections to young rats to determine whether this could be a safe and functional strategy to treat the SOD1(G93A) rat model of ALS and, therefore, translated to a therapy for ALS patients...
April 2017: Gene Therapy
https://www.readbyqxmd.com/read/28240753/a-comparative-study-of-the-structure-and-bonding-in-heavier-pnictinidene-complexes-are-m-co-n-e-as-sb-and-bi-m-cr-mo-w-and-fe
#14
Iva Vránová, Vít Kremláček, Milan Erben, Jan Turek, Roman Jambor, Aleš Růžička, Mercedes Alonso, Libor Dostál
N,C,N-Chelated pnictinidenes ArE [where E = As (1), Sb (2) or Bi (3); Ar = C6H3-2,6-(CH[double bond, length as m-dash]Nt-Bu)2] were used as ligands for the coordination of transition metal carbonyls. Thus, the reaction of 1-3 with [M(CO)5THF] (where M = Cr, W) or [Mo(CO)5(Me3N)] gave complexes [(ArE)M(CO)5] [where E = As and M = Cr (1a), Mo (1b), W (1c); E = Sb and M = Cr (2a), Mo (2b), W (2c); E = Bi and M = Cr (3a), Mo (3b), W (3c)]. Analogously, the treatment of 1-3 with [Fe2(CO)9] resulted in the formation of the complexes [(ArE)Fe(CO)4] [where E = As (1d), Sb (2d) or Bi (3d)]...
March 14, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28225575/25-hydroxy-vitamin-d-suppresses-hepatitis-c-virus-replication-and-contributes-to-rapid-virological-response-of-treatment-efficacy
#15
Jee-Fu Huang, Yu-Min Ko, Chung-Feng Huang, Ming-Lun Yeh, Chia-Yen Dai, Meng-Hsuan Hsieh, Ching-I Huang, Hua-Ling Yang, Shu-Chi Wang, Zu-Yau Lin, Shinn-Chern Chen, Ming-Lung Yu, Wan-Long Chuang
AIM: 25-hydroxy vitamin D (Vit D) plays a role in treatment outcomes in chronic hepatitis C virus (HCV) infection (CHC). We aimed to clarify HCV replication is inhibited by Vit D in HCV replicon cells. Clinical implication was assessed for rapid virological response (RVR) and sustained virological response (SVR) among those patients receiving anti-viral therapy. METHODS: Cell survival and viral loads were observed in Con1 (genotype-1b) and J6/JFH (genotype-2a) cells treated with different doses of Vit D...
February 22, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28213641/role-of-levothyroxine-and-vitamin-e-supplementation-in-the-treatment-of-oxidative-stress-induced-injury-and-apoptosis-of-myocardial-cells-in-hypothyroid-rats
#16
J Ye, X Zhong, Y Du, C Cai, T Pan
OBJECTIVE: To explore the underlying mechanism and treatment of myocardial injury caused by hypothyroidism, we evaluated oxidative stress in serum and myocardial tissue of hypothyroid rats. The effect of levothyroxine (LT4) replacement therapy and vitamin E (VitE) supplementation on oxidative stress-induced injury and apoptosis of myocardial tissue is examined. METHODS: Male Sprague-Dawley rats were divided into five groups: normal control group, propylthiouracil group (PTU group), LT4 treatment group (PTU + LT4 group), vitamin E treatment group (PTU + VitE group), and combined treatment group (PTU + LT4 + VitE group)...
February 17, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28210072/the-parenteral-vitamin-c-improves-sepsis-and-sepsis-induced-multiple-organ-dysfunction-syndrome-via-preventing-cellular-immunosuppression
#17
Yu-Lei Gao, Bin Lu, Jian-Hua Zhai, Yan-Cun Liu, Hai-Xia Qi, Ying Yao, Yan-Fen Chai, Song-Tao Shou
Cellular immunosuppression appears to be involved in sepsis and sepsis-induced multiple organ dysfunction syndrome (MODS). Recent evidence showed that parenteral vitamin C (Vit C) had the ability to attenuate sepsis and sepsis-induced MODS. Herein, we investigated the impact of parenteral Vit C on cellular immunosuppression and the therapeutic value in sepsis. Using cecal ligation and puncture (CLP), sepsis was induced in WT and Gulo(-/-) mice followed with 200 mg/Kg parenteral Vit C administration. The immunologic functions of CD4(+)CD25(+) regulatory T cells (Tregs) and CD4(+)CD25(-) T cells, as well as the organ functions, were determined...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28178330/comparative-study-of-extrapolative-factors-linked-with-oxidative-injury-and-anti-inflammatory-status-in-chronic-kidney-disease-patients-experiencing-cardiovascular-distress
#18
Mahmood Rasool, Muhammad Abdul Basit Ashraf, Arif Malik, Sulayman Waquar, Shahida Aziz Khan, Mahmood Husain Qazi, Waseem Ahmad, Muhammad Asif, Sami Ullah Khan, Ahmad Zaheer, Muther Mansoor Qaisrani, Abdul Rehman Khan, Aamir Iqbal, Amir Raza, Saima Iram, Kashif Kamran, Asim Iqbal, Mohammad Zahid Mustafa, Hani Choudhry, Mazin A Zamzami, Wesam H Abdulaal, Mohammad Sarwar Jamal
BACKGROUND: Chronic kidney disease (CKD) is a group of heterogeneous abnormalities affecting the function and structure of the kidney and mostly further proceeds to cardiovascular damage prior to end stage renal disease (ESRD). The oxidative insult and inflammatory mediators have some undefined role in CKD and cardiovascular complications. It is therefore, aimed at to pin point the predictive factors in the development of cardiovascular disorder in patients with chronic kidney disease...
2017: PloS One
https://www.readbyqxmd.com/read/28169974/f-calprotectin-and-blood-markers-correlate-to-quality-of-life-in-pediatric-inflammatory-bowel-disease
#19
Katrine Carlsen, Christian Jakobsen, Thomas Kallemose, Anders Paerregaard, Lene Buhl Riis, Pia Munkholm, Vibeke Wewer
OBJECTIVES: Our aim was to investigate predictors of Health Related Quality of Life (HRQoL) with respect to changes in disease parameters over time in children with Inflammatory Bowel Disease (IBD). METHODS: This was a prospective longitudinal study examining the association between HRQoL (IMPACT III) and symptom scores (PCDAI, abbrPUCAI), fecal calprotectin (FC) measures and blood analyses (C-reactive protein [CRP], erythrocyte sedimentation-rate [ESR], orosomucoid [ORM], albumin [ALB], hemoglobin [HB] and vitamin-D [VIT-D]) in a cohort of 10-17 years old IBD patients...
February 4, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28127705/the-effects-of-vitamin-c-on-hypothyroidism-associated-learning-and-memory-impairment-in-juvenile-rats
#20
Farimah Beheshti, Sareh Karimi, Farzaneh Vafaee, Mohammad Naser Shafei, Hamid Reza Sadeghnia, Mosa Al Reza Hadjzadeh, Mahmoud Hosseini
In this study the effects of Vitamin C (Vit C) on hypothyroidism-associated learning and memory impairment in juvenile rats was investigated. The pregnant rats were kept in separate cages. After delivery, they were randomly divided into six groups and treated: (1) Control; (2) Propylthiouracil (PTU) which 0.005% PTU in their drinking; (3-5) Propylthiouracil- Vit C groups; besides PTU, dams in these groups received 10, 100 and 500 mg/kg Vit C respectively, (6) one group as a positive control; the intact rats received an effective dose, 100 mg/kg Vit...
June 2017: Metabolic Brain Disease
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