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https://www.readbyqxmd.com/read/28937639/sleep-disorders-in-childhood-neurological-diseases
#1
REVIEW
Abdullah Tolaymat, Zhao Liu
Sleep problems are frequently addressed as a primary or secondary concern during the visit to the pediatric neurology clinic. Sleep disorders can mimic other neurologic diseases (e.g., epilepsy and movement disorders), and this adds challenges to the diagnostic process. Sleep disorders can significantly affect the quality of life and functionality of children in general and those with comorbid neurological diseases in particular. Understanding the pathophysiology of sleep disorders, recognizing the implications of sleep disorder in children with neurologic diseases and behavioral difficulties, and early intervention continue to evolve resulting in better neurocognitive outcomes...
September 22, 2017: Children
https://www.readbyqxmd.com/read/28937508/status-dystonicus-in-childhood
#2
Daniel E Lumsden, Mary D King, Nicholas M Allen
PURPOSE OF REVIEW: Dystonia is a common paediatric neurological condition. At its most severe, dystonia may lead to life-threatening complications, a state termed status dystonicus. This review provides an update on the definition, causes, management and outcome of childhood status dystonicus. RECENT FINDINGS: High-quality studies in childhood status dystonicus are lacking, though an increasing number of case series have been published. Status dystonicus appears to occur more frequently in children compared with adults, with a clear precipitant identified in around two-thirds of cases...
September 20, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28937466/compressive-myelopathy-in-congenital-kyphosis-of-the-upper-thoracic-spine-a-retrospective-study-of-6-cases
#3
Zhengfeng Zhang, Honggang Wang, Wenjie Zheng
STUDY DESIGN: A retrospective study. OBJECTIVE: The goal of this retrospective study was to describe the uncommon presentation of neurological deficits in patients with congenital kyphosis of the upper thoracic spine (T1-T4). SUMMARY OF BACKGROUND DATA: Congenital kyphosis is an uncommon deformity but can potentially lead to spinal cord compression and paraplegia, particularly in type I (failure of formation) deformities. Few reports have described compressive myelopathy associated with congenital kyphosis of the upper thoracic spine...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28937458/transpedicular-corpectomy-and-cage-placement-in-the-treatment-of-traumatic-lumbar-burst-fractures
#4
Martin H Pham, Alexander Tuchman, Thomas C Chen, Frank L Acosta, Patrick C Hsieh, John C Liu
STUDY DESIGN: Retrospective review. OBJECTIVE: To review the feasibility of a posterior-only approach for instrumented reconstruction in lumbar burst fractures. BACKGROUND: Burst fractures of the lumbar spine have been treated through a variety of techniques, including anterior, posterior, or combined approaches. Here we review series of patients undergoing posterior-only transpedicular corpectomy with instrumented fusion for traumatic lumbar burst fracture...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28935818/increased-mir-124-3p-in-microglial-exosomes-following-traumatic-brain-injury-inhibits-neuronal-inflammation-and-contributes-to-neurite-outgrowth-via-their-transfer-into-neurons
#5
Shan Huang, Xintong Ge, Jinwen Yu, Zhaoli Han, Zhenyu Yin, Ying Li, Fanglian Chen, Haichen Wang, Jianning Zhang, Ping Lei
Neuronal inflammation is the characteristic pathologic change of acute neurologic impairment and chronic traumatic encephalopathy after traumatic brain injury (TBI). Inhibiting the excessive inflammatory response is essential for improving the neurologic outcome. To clarify the regulatory mechanism of microglial exosomes on neuronal inflammation in TBI, we focused on studying the impact of microglial exosomal miRNAs on injured neurons in this research. We used a repetitive (r)TBI mouse model and harvested the injured brain extracts from the acute to the chronic phase of TBI to treat cultured BV2 microglia in vitro The microglial exosomes were collected for miRNA microarray analysis, which showed that the expression level of miR-124-3p increased most apparently in the miRNAs...
September 21, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28933425/carnosine-suppresses-oxygen-glucose-deprivation-recovery-induced-proliferation-and-migration-of-reactive-astrocytes-of-rats-in-vitro
#6
Li Ou-Yang, Yuan Liu, Bing-Yu Wang, Pei Cao, Jing-Jing Zhang, Yu-Yan Huang, Yao Shen, Jian-Xin Lyu
Glial scar formation resulted from excessive astrogliosis limits axonal regeneration and impairs recovery of function, thus an intervention to ameliorate excessive astrogliosis is crucial for the recovery of neurological function after cerebral ischemia. In this study we investigated the effects of carnosine, an endogenous water-soluble dipeptide (β-alanyl-L-histidine), on astrogliosis of cells exposed to oxygen-glucose deprivation/recovery (OGD/R) in vitro. Primary cultured rat astrocytes exhibited a significant increase in proliferation at 24 h recovery after OGD for 2 h...
September 21, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28933344/first-outbreak-of-zika-virus-in-the-continental-united-states-a-modelling-analysis
#7
Giovanni Marini, Giorgio Guzzetta, Roberto Rosà, Stefano Merler
Since 2015, Zika virus (ZIKV) has spread throughout Latin and Central America. This emerging infectious disease has been causing considerable public health concern because of severe neurological complications, especially in newborns after congenital infections. In July 2016, the first outbreak in the continental United States was identified in the Wynwood neighbourhood of Miami-Dade County, Florida. In this work, we investigated transmission dynamics using a mathematical model calibrated to observed data on mosquito abundance and symptomatic human infections...
September 14, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28933225/inflammation-relates-to-chronic-behavioral-and-neurological-symptoms-in-military-personnel-with-traumatic-brain-injuries
#8
Christina Devoto, Lindsay Arcurio, Joseph Fetta, Mary Ley, Tamar Rodney, Rebekah Kanefsky, Jessica Gill
Studies have shown that the presence of acute inflammation during recovery is indicative of poor outcomes after a traumatic brain injury (TBI); however, the role of chronic inflammation in predicting post-TBI-related symptoms remains poorly understood. The purpose of this study was to compare inflammatory biomarkers (tumor necrosis factor [TNF]-α, interleukin [IL]-6, and IL-10) in active duty personnel who either sustained or did not sustain a TBI. Service members were also assessed for post-traumatic stress disorder (PTSD), depression, and quality of life through self-reported measures...
July 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28932359/coronary-angiography-findings-in-cardiac-arrest-patients-with-non-diagnostic-post-resuscitation-electrocardiogram-a-comparison-of-shockable-and-non-shockable-initial-rhythms
#9
Pedro Martínez-Losas, Pablo Salinas, Carlos Ferrera, María Teresa Nogales-Romo, Francisco Noriega, María Del Trigo, Iván Javier Núñez-Gil, Luis Nombela-Franco, Nieves Gonzalo, Pilar Jiménez-Quevedo, Javier Escaned, Antonio Fernández-Ortiz, Carlos Macaya, Ana Viana-Tejedor
AIM: To investigate the impact of coronary artery disease in a cohort of patients resuscitated from cardiac arrest with non-diagnostic electrocardiogram. METHODS: From March 2004 to February 2016, 203 consecutive patients resuscitated from in or out-of-hospital sudden cardiac arrest and non-diagnostic post-resuscitation electrocardiogram (defined as ST segment elevation or pre-sumably new left bundle branch block) who underwent invasive coronary angiogram during hospitalization were included...
August 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28931979/comparison-of-immediate-effects-between-two-medical-stretching-techniques-on-hamstrings-flexibility
#10
Thanda Aye, Tsugumi Kuramoto-Ahuja, Heonsoo Han, Hitoshi Maruyama
[Purpose] The aim of this study was to compare immediate effects between new medical stretching (NMS) and conventional medical stretching (CMS) techniques on Hamstrings flexibility. [Subjects and Methods] Thirteen healthy adult males, with finger floor distance (FFD) less than zero centimeter, without known musculoskeletal and neurological impairment in spine or lower extremities, were included. The subjects were randomly allocated to two groups. The subjects were instructed to perform NMS and CMS (hold for 30 seconds once, twice for each side of lower extremity) for both sides (total two minutes, only one session for one day)...
September 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28931439/effects-of-whole-body-vibration-exercise-on-neuromuscular-function-for-individuals-with-knee-osteoarthritis-study-protocol-for-a-randomized-controlled-trial
#11
Zhangqi Lai, Xueqiang Wang, Seullee Lee, Xihe Hou, Lin Wang
BACKGROUND: Knee osteoarthritis (KOA) is a leading cause of public disability. Neuromuscular function contributes to the development and/or progression of KOA. Whole body vibration (WBV) exercise improve the neuromuscular function of patients with neurological disorders and even that of older patients with limited exercise options. Therefore, WBV exercise may offer an efficient and alternative treatment for individuals with KOA. However, the effects of WBV training on the neuromuscular function of individuals with KOA remain unclear...
September 20, 2017: Trials
https://www.readbyqxmd.com/read/28930904/spontaneous-reduction-of-fractured-thoracolumbar-spine-with-complete-dislocation-case-report-with-literature-review
#12
Chen Zhao, Bing Zhang, Jiandang Shi, Yaping Li, Long Pang
Fractures and dislocations with complete lateral displacement of the spine at the lumbar and thoracic levels are some of the most severe types of thoracolumbar trauma. They are usually caused by high-energy trauma and accompanied by extreme, life-threatening injuries and neurological deficits that vary in severity, which may delay operative intervention. It is often difficult to reduce such a complex fracture-dislocation because of the force that the muscles exert on the bone and the injured part of the spinal cord...
September 2017: Orthopaedic Nursing
https://www.readbyqxmd.com/read/28930237/qigong-exercise-may-reduce-serum-tnf-%C3%AE-levels-and-improve-sleep-in-people-with-parkinson-s-disease-a-pilot-study
#13
Sanghee Moon, Marshall Schmidt, Irina V Smirnova, Yvonne Colgrove, Wen Liu
Background: Inflammatory cytokine levels are often elevated in people with Parkinson's disease (PD). People with PD often experience sleep disturbances that significantly impact quality of life. Past studies suggest inflammatory cytokines may be associated with various symptoms of PD. Benefits of Qigong, a mind-body exercise, have been shown in different neurological conditions, but there is still a lack of clinical evidence in the PD population. Methods: Ten people with PD were recruited and randomly assigned into two groups receiving six weeks of Qigong (experimental group) or sham Qigong (control group) intervention...
April 23, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28928747/modulation-of-multiple-sclerosis-and-its-animal-model-experimental-autoimmune-encephalomyelitis-by-food-and-gut-microbiota
#14
REVIEW
Ward J van den Hoogen, Jon D Laman, Bert A 't Hart
Multiple sclerosis (MS) is an autoimmune neurological disease characterized by chronic inflammation of the central nervous system (CNS), leading to demyelination, axonal damage, and symptoms such as fatigue and disability. Although the cause of MS is not known, the infiltration of peripherally activated immune cells into the CNS has a key pathogenic role. Accumulating evidence supports an important role of diet and gut microbiota in immune-mediated diseases. Preclinical as well as clinical studies suggest a role for gut microbiota and dietary components in MS...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28928649/changes-in-electroencephalography-complexity-using-a-brain-computer-interface-motor-observation-training-in-chronic-stroke-patients-a-fuzzy-approximate-entropy-analysis
#15
Rui Sun, Wan-Wa Wong, Jing Wang, Raymond Kai-Yu Tong
Entropy-based algorithms have been suggested as robust estimators of electroencephalography (EEG) predictability or regularity. This study aimed to examine possible disturbances in EEG complexity as a means to elucidate the pathophysiological mechanisms in chronic stroke, before and after a brain computer interface (BCI)-motor observation intervention. Eleven chronic stroke subjects and nine unimpaired subjects were recruited to examine the differences in their EEG complexity. The BCI-motor observation intervention was designed to promote functional recovery of the hand in stroke subjects...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28928634/transcranial-alternating-current-stimulation-tacs-mechanisms-and-protocols
#16
REVIEW
Amir V Tavakoli, Kyongsik Yun
Perception, cognition and consciousness can be modulated as a function of oscillating neural activity, while ongoing neuronal dynamics are influenced by synaptic activity and membrane potential. Consequently, transcranial alternating current stimulation (tACS) may be used for neurological intervention. The advantageous features of tACS include the biphasic and sinusoidal tACS currents, the ability to entrain large neuronal populations, and subtle control over somatic effects. Through neuromodulation of phasic, neural activity, tACS is a powerful tool to investigate the neural correlates of cognition...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28927210/navigation-and-image-injection-for-control-of-bone-removal-and-osteotomy-planes-in-spine-surgery
#17
Michael Kosterhon, Angelika Gutenberg, Sven Rainer Kantelhardt, Elefterios Archavlis, Alf Giese
BACKGROUND AND IMPORTANCE: In contrast to cranial interventions, neuronavigation in spinal surgery is used in few applications, not tapping into its full technological potential. We have developed a method to preoperatively create virtual resection planes and volumes for spinal osteotomies and export 3-D operation plans to a navigation system controlling intraoperative visualization using a surgical microscope's head-up display. The method was developed using a Sawbone ® model of the lumbar spine, demonstrating feasibility with high precision...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28925974/if-you-build-it-they-will-come-initial-experience-with-a-multi-disciplinary-pediatric-neurocritical-care-follow-up-clinic
#18
Cydni N Williams, Aileen Kirby, Juan Piantino
Pediatric Neurocritical Care diagnoses account for a large proportion of intensive care admissions. Critical care survivors suffer high rates of long-term morbidity, including physical disability, cognitive impairment, and psychosocial dysfunction. To address these morbidities in Pediatric Neurocritical Care survivors, collaboration between Pediatric Neurology and Pediatric Critical Care created a multidisciplinary follow-up clinic providing specialized evaluations after discharge. Clinic referrals apply to all Pediatric Neurocritical Care patients regardless of admission severity of illness...
September 19, 2017: Children
https://www.readbyqxmd.com/read/28925885/spreading-depolarization-waves-in-neurological-diseases-a-short-review-about-its-pathophysiology-and-clinical-relevance
#19
Yağmur Çetin Taş, İhsan Solaroğlu, Yasemin Gürsoy-Özdemir
Lesion growth following acutely injured brain tissue after stroke, subarachnoid hemorrhage and traumatic brain injury is an important issue and a new target area for promising therapeutic interventions. Spreading depolarization or peri-lesion depolarization waves were demonstrated as one of the significant contributors of continued lesion growth. In this short review, we discuss the pathophysiology for SD forming events and try to list findings detected in neurological disorders like migraine, stroke, subarachnoid hemorrhage and traumatic brain injury in both human as well as experimental studies...
September 15, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28924067/-neurosurgical-outcomes-of-intradural-extramedullary-spinal-tumors-in-97-cases-siberian-experience
#20
Vadim Anatolyevich Byvaltsev, Bair Batiyevich Damdinov, Evgenii Georgiyevich Belykh, Kristina Olegovna Ivanova, Vladimir Alekseevich Sorokovikov, Kenzo Tsunetoshi, Ryuhei Kitai, Kenichiro Kikuta
We retrospectively investigated the clinical presentation and outcome of patients with spinal intradural extramedullary tumors, which had been surgically treated. A total of 97 consecutive patients(32 males and 65 females;mean age, 48 years;range, 17-79 years)underwent surgery between 2004 and 2014 at Irkutsk State Medical Academy and affiliated hospitals. To determine presentation and outcomes associated with these tumors, we evaluated the waiting period before surgery, neurological symptoms including motor, sensory, urinary, and rectal dysfunction, modified McCormick scale, Macnab's outcome assessment of patient satisfaction, surgical procedure, tumor location, and histological diagnosis...
September 2017: No Shinkei Geka. Neurological Surgery
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