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https://www.readbyqxmd.com/read/29319136/the-use-of-99mtc-phytate-for-assessment-the-protective-effect-of-vitamin-e-against-hepatotoxicity-induced-by-methotrexat-in-rat
#1
Hossein Amirfakhrian, Seyed Mohammad Abedi, Hossein Sadeghi, Soheil Azizi, Seyed Jalal Hosseinimehr
In this study, we investigated the protective effect of vitamin E against methotrexate (MTX)-induced hepatotoxicity by quantitative liver 99mTc-phytate uptake and liver imaging and to compare its effect with histopathology in rat. Rats were divided into five groups as control, solvent, Vit E (100 mg/kg), MTX (20 mg/kg), Vit E + MTX and. Vit E was intraperitoneally administrated for 17 days before MTX injection and continued for 4 days. 99mTc-phytate was injected through the tail of rats after the drug administration...
January 10, 2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29311636/loss-of-function-variants-in-adcy3-increase-risk-of-obesity-and-type-2-diabetes
#2
Niels Grarup, Ida Moltke, Mette K Andersen, Maria Dalby, Kristoffer Vitting-Seerup, Timo Kern, Yuvaraj Mahendran, Emil Jørsboe, Christina V L Larsen, Inger K Dahl-Petersen, Arthur Gilly, Daniel Suveges, George Dedoussis, Eleftheria Zeggini, Oluf Pedersen, Robin Andersson, Peter Bjerregaard, Marit E Jørgensen, Anders Albrechtsen, Torben Hansen
We have identified a variant in ADCY3 (encoding adenylate cyclase 3) associated with markedly increased risk of obesity and type 2 diabetes in the Greenlandic population. The variant disrupts a splice acceptor site, and carriers have decreased ADCY3 RNA expression. Additionally, we observe an enrichment of rare ADCY3 loss-of-function variants among individuals with type 2 diabetes in trans-ancestry cohorts. These findings provide new information on disease etiology relevant for future treatment strategies.
January 8, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29298280/complete-objective-response-stable-for-5-years-with-the-di-bella-method-of-multiple-metastatic-carcinoma-of-the-breast
#3
Giuseppe Di Bella, Biagio Colori, Rosilde Toscano
Breast cancer is the most common cancer and the leading cause of cancer death among women. Despite all efforts, about 11,939 deaths and 50,000 new diagnoses for breast cancer were estimated among Italian women in 2016. Therefore new approaches are needed to improve the survival and higher remission rates. We present a case of a woman with carcinoma of the breast and multiple metastases after right mastectomy, axillary dissection, repeated cycles of chemo and radiotherapy, and estrogen block. Biological method formulated by Prof...
December 4, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29290043/the-effects-of-vitamin-e-on-brain-derived-neurotrophic-factor-tissues-oxidative-damage-and-learning-and-memory-of-juvenile-hypothyroid-rats
#4
Yousef Baghcheghi, Farimah Beheshti, Mohammad Naser Shafei, Hossein Salmani, Hamid Reza Sadeghnia, Mohammad Soukhtanloo, Akbar Anaeigoudari, Mahmoud Hosseini
The effects of vitamin E (Vit E) on brain derived neurotrophic factor (BDNF) and brain tissues oxidative damage as well as on learning and memory impairments in juvenile hypothyroid rats were examined. The rats were grouped as: (1) Control; (2) Propylthiouracil (PTU); (3) PTU-Vit E and (4) Vit E. PTU was added to their drinking water (0.05%) during 6 weeks. Vit E (20 mg/kg) was daily injected (IP). Morris water maze (MWM) and passive avoidance (PA) were carried out. The animals were deeply anesthetized and the brain tissues were removed for biochemical measurements...
December 30, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29278023/effect-of-%C3%AE-tocopherol-megadoses-on-hematologic-parameters-and-antioxidant-capacity-of-rats-in-an-ultraendurance-probe
#5
V J Clemente-Suárez, J Mielgo-Ayuso, J L Quiles, A Varela-Lopez, P Aranda
This study was aimed to analyze the effect of two different megadoses of α-tocopherol (vit E) in the antioxidant activity and red and white blood series of Wistar rats after a 180-min ultraendurance probe. Three groups of 10 rats were analyzed; VEAG: acute administration of a megadoses of 5,000 IU/kg of vit E the day before the probe; VECG: chronic administration of 1,000 IU/kg/day of vit E for 6 days before the probe; CG: placebo administration. VEAG presented white cells, red blood cells, hematocrit, hemoglobin values significantly higher than CG and VECG (p < 0...
December 1, 2017: Physiology International
https://www.readbyqxmd.com/read/29247592/relationship-between-smoking-and-and-total-antioxidant-status-total-oxidant-status-oxidative-stress-index-vit-c-vit-e
#6
M Merve Karademirci, Ruhusen Kutlu, Ibrahim Kilinc
BACKGROUND: Tobacco smoke contains many toxic, carcinogenic and mutagenic chemicals, as well as stable and unstable free radicals. In this study, we aimed to assess the vitamin E, vitamin C and total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) in smoking and non-smoking men. METHODS: This case control analytical study was conducted on 78 smoking and 82 non-smoking men. Fagerström nicotine dependence test was used in order to assess the participants'addiction status...
December 16, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29232192/vitamin-e-improved-redox-homeostasis-in-heart-and-aorta-of-hypothyroid-rats
#7
M Hedayati, S Niazmand, M Hosseini, Y Baghcheghi, F Beheshti, S Niazmand
OBJECTIVES: The objective of this study was to evaluate the effect of vitamin E on the oxidative stress parameters and antioxidant defense enzymes in the heart and aorta of 6-n-propylthiouracil (PTU)-induced hypothyroid rats. METHODS: The animals were divided into 4 experimental groups: Group 1 (Euthyroid) received tap water, Group 2 (Hypothyroid) received 0.05 % of PTU in dissolved in their drinking water, Group 3 (PTU+Vit E) hypothyroid rats treated with vitamin E, and Group 4 (Euthyroid+Vit E)...
October 26, 2017: Endocrine Regulations
https://www.readbyqxmd.com/read/29195948/effects-of-soil-type-and-organic-fertilizers-on-fatty-acids-and-vitamin-e-in-korean-ginseng-panax-ginseng-meyer
#8
Ill-Min Chung, Jae-Kwang Kim, Jin-Hee Yang, Ji-Hee Lee, Sung-Kyu Park, Na-Young Son, Seung-Hyun Kim
This study examined the effects of soil type and fertilizer regimes on variations in fatty acids (FAs) and vitamin E (Vit-E) in 6-year-old ginseng roots. We observed significant variation in both FA and Vit-E contents owing to the type and quantity of organic fertilizer used in each soil type during cultivation. Unsaturated FAs were approximately 2.7-fold higher in ginseng than in saturated FAs. Linoleic, palmitic, and oleic acids were the most abundant FAs detected in ginseng roots. Additionally, α-tocopherol was the major Vit-E detected...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29175624/copper-isotopic-record-in-soils-and-tree-rings-near-a-copper-smelter-copperbelt-zambia
#9
Martin Mihaljevič, Alice Jarošíková, Vojtěch Ettler, Aleš Vaněk, Vít Penížek, Bohdan Kříbek, Vladislav Chrastný, Ondra Sracek, Jakub Trubač, Miroslav Svoboda, Imasiku Nyambe
The copper (Cu) content and isotopic composition were studied in soils and in pine tree rings at locations close to and far from the Cu smelter, located at Kitwe, Zambia. The soil in the remote area contained 25-75mgkg-1 Cu, whereas the soil close to the smelter contained 207-44,000mgkg-1 Cu. The δ65Cu at the remote area and close to the smelter varied in the range -0.40 to -0.11‰, and -0.44 to 0.01‰ respectively. The δ65Cu of the surface soil at both profiles (-0.44 to -0.40‰) is similar to the isotopic composition of the concentrates processed in the smelter (-0...
November 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29163645/hypervitaminosis-d3-in-broiler-chicks-histopathological-immunomodulatory-and-immunohistochemical-approach
#10
R Kumar, R S Brar, H S Banga
The present study was undertaken to investigate the toxic effects of higher doses (1,00,000 IU i.e. 2.5 mg/kg body weight (BW)) of vitamin D3, concomitantly with bacterial endotoxins (lipopolysaccharides: LPS) to study the immunomodulatory potential of vitamin D3 in IBL-80 broiler chicks. The chicks were divided into four groups [group I (NSS), group II (LPS), group III (Vit. D3 + NSS), and group IV (Vit. D3 + LPS)] containing eight chicks in each group, treated accordingly for 21 days. Birds were kept under close observation for apparent clinical signs and symptoms...
2017: Iranian Journal of Veterinary Research
https://www.readbyqxmd.com/read/29130986/skin-test-reactivity-to-hymenoptera-venom-after-venom-immunotherapy-correlates-inversely-with-the-igg-ige-ratio
#11
Ieva Saulite, Wolfram Hoetzenecker, Emmanuella Guenova, Peter Schmid-Grendelmeier, Martin Glatz
BACKGROUND: Skin test reactivity to hymenoptera venom and venom-specific IgE are important for diagnosing venom allergy and deciding on the appropriate allergen for venom immunotherapy (VIT). Longitudinal data on skin test reactivity during VIT and their correlation with venom-specific immunoglobulin (Ig)E and IgG are scarce. METHODS: We retrospectively analyzed shifts in skin test reactivity and serum levels of venom-specific IgE and IgG in patients allergic to hymenoptera venom before the initiation of VIT with ultrarush therapy and after ≥3 years of VIT...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29130299/-role-of-vitamin-d-in-female-reproduction
#12
Vincenzo DE Leo, Valentina Cappelli, Giuseppe Morgante, Alessandra DI Sabatino
La vit. D, o calcitriolo, è stata identificata inizialmente nei primi anni '20 ed ha un ruolo chiave nella regolazione del metabolismo osseo, nell'omeostasi del calcio e del fosforo e nel promuovere la mineralizzazione ossea. Le azioni della vit. D sono mediante tramite un recettore nucleare (VDR), che è espresso in numerosi organi come l'intestino, l'osso e il rene, ma anche nelle gonadi, nel seno, nel pancreas, nel sistema cardiovascolare, nel cervello (microglia) e nelle cellule del sistema immunitario...
November 10, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/29068590/vitamin-e-%C3%AE-tocopherol-attenuates-toxicity-and-oxidative-stress-induced-by-aflatoxin-in-rats
#13
Seval Yılmaz, Emre Kaya, Selim Comakli
BACKGROUND: Aflatoxins are toxic metabolites produced by Aspergillus flavus and Aspergillus parasiticus and are classified as group I carcinogens by the International Agency for Research on Cancer (IARC). OBJECTIVES: The purpose of this study was to investigate the possible preventive role of vitamin E (Vit E) on aflatoxin (AF) induced toxicity by using biochemical and histopathological approaches. MATERIAL AND METHODS: Wistar-Albino rats were divided into 4 groups as follows: control group, Vit E group (Vit E was administered), AFB1 group (a single dose of AFB1 was administered), AF + Vit E group (AF and Vit E were administered)...
September 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29052324/effect-of-heat-stress-during-in-vitro-maturation-on-developmental-competence-of-vitrified-bovine-oocytes
#14
M Vendrell-Flotats, N Arcarons, E Barau, M López-Béjar, T Mogas
Heat-shock protein 70 (HSP70) plays a crucial role as intracellular cytoprotectant and molecular chaperone. A phenomenon of heat stress (HS) leads to production of these proteins that could be beneficial to cells during cryopreservation, which is also a stressful process for the cell. This study aimed to evaluate the protective effect of exposure of bovine oocytes to moderate HS during in vitro maturation (IVM) prior vitrification. First, oocytes were subjected to HS (41.5°C for 1 hr) at 0, 4, 8, 12 or 16 of IVM...
October 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29047764/surface-topography-measurement-by-frequency-sweeping-digital-holography
#15
Vít Lédl, Pavel Psota, František Kaván, Ondřej Matoušek, Pavel Mokrý
High-precision measurements of mechanical parts' surface topography represent an essential task in many industry sectors. Examples of such tasks are, e.g., precise alignments of opto-mechanical systems, large object deformation measurements, evaluation of object shape, and many others. Today, the standard method used for such measurements is based on use of coordinate measuring machines (CMMs). Unfortunately, CMMs have severe shortcomings: low measurement point density, long measurement time, risk of surface damage, etc...
October 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29043459/mobility-of-pb-zn-cu-and-as-in-disturbed-forest-soils-affected-by-acid-rain
#16
Yulia V Kochergina, Martin Udatný, Vít Penížek, Martin Mihaljevič
Early efforts at remediation of contaminated soils involve overturn or removal of the uppermost soil horizons. We find that such disruption is counterproductive, as it actually increases the mobility of the heavy metals involved. In our study, we sought to replicate in a controlled manner this commonly used remediation strategy and measure Pb, Zn, Cu and As concentrations in all soil horizons-both prior to and 1 year after disruption by trenching. BCR analyses (sequential leaching) indicate that Pb is affected to the greatest degree and is most highly mobile; however, Zn and As remain insoluble, thus partially ameliorating the detrimental effect...
October 18, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29040674/evaluation-of-apoptotic-and-autophagic-related-protein-expressions-before-and-after-ivm-of-fresh-slow-frozen-and-vitrified-pre-pubertal-mouse-testicular-tissue
#17
L Dumont, F Chalmel, A Oblette, B Berby, A Rives, V Duchesne, C Rondanino, N Rives
STUDY QUESTION: Do freezing and in vitro culture procedures enhance the expression of proteins involved in apoptotic or autophagic pathways in murine pre-pubertal testicular tissue? SUMMARY ANSWER: IVM strongly modified apoptosis- and autophagy-related relative protein levels in mice testicular tissue whereas the impact of cryopreservation procedures was minimal at the end of the culture. WHAT IS KNOWN ALREADY: In vitro spermatogenesis remains a challenging technical issue as it imposes to find a very close balance between survival and death of germ cell natural precursors (i...
November 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28966308/vitamin-e-reversed-apoptosis-of-cardiomyocytes-induced-by-exposure-to-high-dose-formaldehyde-during-mice-pregnancy
#18
Dongyuan Wu, Zhirong Jiang, Bing Gong, Yue Dou, Mingxuan Song, Xiaoxia Song, Yu Tian
In this study, we investigated the protection effect of Vitamin E (Vit E) on formaldehyde (FA) exposure during pregnancy induced apoptosis of cardiomyocytes, and used an HL-1 cell line to confirmed the findings in vivo.Pregnant mice received different doses of FA (0.5 mg/kg, 1.0 mg/kg, 1.5 mg/kg, 0.1 μg Vit E, or 1.5 mg/kg + 0.1 μg Vit E). TUNEL staining was used to reveal the apoptosis in cardiomyocytes, and SOD, MDA, GSH, Livin, and Caspase-3 in cardiomyocytes were detected by ELISA, RT-PCR, and Western blot...
October 21, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28949229/first-measurement-of-transverse-spin-dependent-azimuthal-asymmetries-in-the-drell-yan-process
#19
M Aghasyan, R Akhunzyanov, G D Alexeev, M G Alexeev, A Amoroso, V Andrieux, N V Anfimov, V Anosov, A Antoshkin, K Augsten, W Augustyniak, A Austregesilo, C D R Azevedo, B Badełek, F Balestra, M Ball, J Barth, R Beck, Y Bedfer, J Bernhard, K Bicker, E R Bielert, R Birsa, M Bodlak, P Bordalo, F Bradamante, A Bressan, M Büchele, W-C Chang, C Chatterjee, M Chiosso, I Choi, S-U Chung, A Cicuttin, M L Crespo, S Dalla Torre, S S Dasgupta, S Dasgupta, O Yu Denisov, L Dhara, S V Donskov, N Doshita, Ch Dreisbach, W Dünnweber, M Dziewiecki, A Efremov, P D Eversheim, M Faessler, A Ferrero, M Finger, M Finger, H Fischer, C Franco, N du Fresne von Hohenesche, J M Friedrich, V Frolov, E Fuchey, F Gautheron, O P Gavrichtchouk, S Gerassimov, J Giarra, F Giordano, I Gnesi, M Gorzellik, A Grasso, M Grosse Perdekamp, B Grube, T Grussenmeyer, A Guskov, D Hahne, G Hamar, D von Harrach, F H Heinsius, R Heitz, F Herrmann, N Horikawa, N d'Hose, C-Y Hsieh, S Huber, S Ishimoto, A Ivanov, Yu Ivanshin, T Iwata, V Jary, R Joosten, P Jörg, E Kabuß, A Kerbizi, B Ketzer, G V Khaustov, Yu A Khokhlov, Yu Kisselev, F Klein, J H Koivuniemi, V N Kolosov, K Kondo, K Königsmann, I Konorov, V F Konstantinov, A M Kotzinian, O M Kouznetsov, Z Kral, M Krämer, P Kremser, F Krinner, Z V Kroumchtein, Y Kulinich, F Kunne, K Kurek, R P Kurjata, A Kveton, A A Lednev, M Levillain, S Levorato, Y-S Lian, J Lichtenstadt, R Longo, A Maggiora, A Magnon, N Makins, N Makke, G K Mallot, B Marianski, A Martin, J Marzec, J Matoušek, H Matsuda, T Matsuda, G V Meshcheryakov, M Meyer, W Meyer, Yu V Mikhailov, M Mikhasenko, E Mitrofanov, N Mitrofanov, Y Miyachi, A Nagaytsev, F Nerling, D Neyret, J Nový, W-D Nowak, G Nukazuka, A S Nunes, A G Olshevsky, I Orlov, M Ostrick, D Panzieri, B Parsamyan, S Paul, J-C Peng, F Pereira, M Pešek, D V Peshekhonov, N Pierre, S Platchkov, J Pochodzalla, V A Polyakov, J Pretz, M Quaresma, C Quintans, S Ramos, C Regali, G Reicherz, C Riedl, N S Rogacheva, M Roskot, D I Ryabchikov, A Rybnikov, A Rychter, R Salac, V D Samoylenko, A Sandacz, C Santos, S Sarkar, I A Savin, T Sawada, G Sbrizzai, P Schiavon, K Schmidt, H Schmieden, K Schönning, E Seder, A Selyunin, O Yu Shevchenko, L Silva, L Sinha, S Sirtl, M Slunecka, J Smolik, A Srnka, D Steffen, M Stolarski, O Subrt, M Sulc, H Suzuki, A Szabelski, T Szameitat, P Sznajder, S Takewaka, M Tasevsky, S Tessaro, G Terça, F Tessarotto, A Thiel, J Tomsa, F Tosello, V Tskhay, S Uhl, A Vauth, J Veloso, M Virius, M Vit, J Vondra, S Wallner, T Weisrock, M Wilfert, J Ter Wolbeek, K Zaremba, P Zavada, M Zavertyaev, E Zemlyanichkina, N Zhuravlev, M Ziembicki
The first measurement of transverse-spin-dependent azimuthal asymmetries in the pion-induced Drell-Yan (DY) process is reported. We use the CERN SPS 190  GeV/c π^{-} beam and a transversely polarized ammonia target. Three azimuthal asymmetries giving access to different transverse-momentum-dependent (TMD) parton distribution functions (PDFs) are extracted using dimuon events with invariant mass between 4.3  GeV/c^{2} and 8.5  GeV/c^{2}. Within the experimental uncertainties, the observed sign of the Sivers asymmetry is found to be consistent with the fundamental prediction of quantum chromodynamics (QCD) that the Sivers TMD PDFs extracted from DY have a sign opposite to the one extracted from semi-inclusive deep-inelastic scattering (SIDIS) data...
September 15, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28946183/cardioprotective-effect-of-phyllanthus-amarus-against-high-fructose-diet-induced-myocardial-and-aortic-stress-in-rat-model
#20
Mallaiah Putakala, Sudhakara Gujjala, Srinivasulu Nukala, Sasi Bhusana Rao Bongu, Nagaraju Chintakunta, Saralakumari Desireddy
Increased number of population with heart stroke/attack is attributed to sedentary lifestyle and consumption of high-sugar diets, especially fructose. The objective of this study is to investigate the cardio-protective activity of aqueous extract of Phyllanthus amarus (PAAE) against high-fructose (HF) diet induced cardiac damage in Wistar rats. Male Wistar rats were randomly assigned into five groups of six animals each: Control (C), Control treated with PAAE (C+PAAE), High fructose diet fed (F), High fructose diet fed treated with PAAE (F+PAAE) and High fructose diet fed treated with Pioglitazone (F+Pio)...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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