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Arterial spin label

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https://www.readbyqxmd.com/read/28810558/functional-assessment-of-prefrontal-lobes-in-patients-with-major-depression-disorder-using-a-dual-mode-technique-of-3d-arterial-spin-labeling-and-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#1
Chang Fu, Dapeng Shi, Yongju Gao, Junling Xu
The aim of this study was to explore the functions of cerebral blood perfusion and glucose metabolism in the prefrontal lobe of patients with major depression disorder (MDD), and to analyze the correlations between these functional changes and depressive symptoms. 3D-arterial spin labeling (ASL) and (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) were successfully performed in 17 patients with MDD and 16 healthy controls in a resting state. The depressive symptoms of the patients were classified into seven factors and scored with the Hamilton Depression Rating Scale...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28809854/in-the-grip-of-worry-cerebral-blood-flow-changes-during-worry-induction-and-reappraisal-in-late-life-generalized-anxiety-disorder
#2
H T Karim, D L Tudorascu, M A Butters, S Walker, H J Aizenstein, C Andreescu
Severe worry includes a complex blend of maladaptive affective and cognitive processes. Contrary to other forms of anxiety, there is no consensus in the field regarding the neural basis of worry. To date, no study has looked at neural patterns associated specifically with in-scanner induction and reappraisal of worry. In this study, we attempt to describe distinct components of the 'neural phenomenology' of worry: induction, maintenance, severity and reappraisal, by using a personalized, in-scanner worry script...
August 15, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28794982/symptom-correlates-of-cerebral-blood-flow-following-acute-concussion
#3
Nathan W Churchill, Michael G Hutchison, Simon J Graham, Tom A Schweizer
Concussion is associated with significant symptoms within hours to days post-injury, including disturbances in physical function, cognition, sleep and emotion. However, little is known about how subjective impairments correlate with objective measures of cerebrovascular function following brain injury. This study examined the relationship between symptoms and cerebral blood flow (CBF) in individuals following sport-related concussion. Seventy university level athletes had CBF measured using Arterial Spin Labelling (ASL), including 35 with acute concussion and 35 matched controls and their symptoms were assessed using the Sport Concussion Assessment Tool 3 (SCAT3)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28792653/comparing-accuracy-and-reproducibility-of-sequential-and-hadamard-encoded-multidelay-pseudocontinuous-arterial-spin-labeling-for-measuring-cerebral-blood-flow-and-arterial-transit-time-in-healthy-subjects-a-simulation-and-in-vivo-study
#4
Jia Guo, Samantha J Holdsworth, Audrey P Fan, Marc R Lebel, Zungho Zun, Ajit Shankaranarayanan, Greg Zaharchuk
PURPOSE: To compare performance of sequential and Hadamard-encoded pseudocontinuous arterial spin labeling (PCASL). MATERIALS AND METHODS: Monte Carlo simulations and in vivo experiments were performed in 10 healthy subjects. Field strength and sequence: 5-delay sequential (5-del. Seq.), 7-delay Hadamard-encoded (7-del. Had.), and a single-delay (1-del.) PCASL, without and with vascular crushing at 3.0T. The errors and variations of cerebral blood flow (CBF) and arterial transit time (ATT) from simulations and the CBF and ATT estimates and variations in gray matter (GM) with different ATT ranges were compared...
August 9, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28790959/brain-processing-of-contagious-itch-in-patients-with-atopic-dermatitis
#5
Christina Schut, Hideki Mochizuki, Shoshana K Grossman, Andrew C Lin, Christopher J Conklin, Feroze B Mohamed, Uwe Gieler, Joerg Kupfer, Gil Yosipovitch
Several studies show that itch and scratching cannot only be induced by pruritogens like histamine or cowhage, but also by the presentation of certain (audio-) visual stimuli like pictures on crawling insects or videos showing other people scratching. This phenomenon is coined "Contagious itch" (CI). Due to the fact that CI is more profound in patients with the chronic itchy skin disease atopic dermatitis (AD), we believe that it is highly relevant to study brain processing of CI in this group. Knowledge on brain areas involved in CI in AD-patients can provide us with useful hints regarding non-invasive treatments that AD-patients could profit from when they are confronted with itch-inducing situations in daily life...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28776469/relationship-between-haemodynamic-impairment-and-collateral-blood-flow-in-carotid-artery-disease
#6
Nolan S Hartkamp, Esben T Petersen, Michael A Chappell, Thomas W Okell, Maarten Uyttenboogaart, Clark J Zeebregts, Reinoud Ph Bokkers
Collateral blood flow plays a pivotal role in steno-occlusive internal carotid artery (ICA) disease to prevent irreversible ischaemic damage. Our aim was to investigate the effect of carotid artery disease upon cerebral perfusion and cerebrovascular reactivity and whether haemodynamic impairment is influenced at brain tissue level by the existence of primary and/or secondary collateral. Eighty-eight patients with steno-occlusive ICA disease and 29 healthy controls underwent MR examination. The presence of collaterals was determined with time-of-flight, two-dimensional phase contrast MRA and territorial arterial spin labeling (ASL) imaging...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28770549/therapy-related-longitudinal-brain-perfusion-changes-in-patients-with-chronic-pelvic-pain-syndrome
#7
Christian Weisstanner, Livio Mordasini, George N Thalmann, Rajeev K Verma, Christian Rummel, Andrea Federspiel, Thomas M Kessler, Roland Wiest
BACKGROUND: The imaging method most frequently employed to identify brain areas involved in neuronal processing of nociception and brain pain perception is blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI). Arterial spin labelling (ASL), in contrast, offers advantages when slow varying changes in brain function are investigated. Chronic pelvic pain syndrome (CPPS) is a disorder of, mostly, young males that leads to altered pain perceptions in structures related to the pelvis...
August 3, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28770207/aberrant-cerebral-blood-flow-in-response-to-hunger-and-satiety-in-women-remitted-from-anorexia-nervosa
#8
Christina E Wierenga, Amanda Bischoff-Grethe, Grace Rasmusson, Ursula F Bailer, Laura A Berner, Thomas T Liu, Walter H Kaye
The etiology of pathological eating in anorexia nervosa (AN) remains poorly understood. Cerebral blood flow (CBF) is an indirect marker of neuronal function. In healthy adults, fasting increases CBF, reflecting increased delivery of oxygen and glucose to support brain metabolism. This study investigated whether women remitted from restricting-type AN (RAN) have altered CBF in response to hunger that may indicate homeostatic dysregulation contributing to their ability to restrict food. We compared resting CBF measured with pulsed arterial spin labeling in 21 RAN and 16 healthy comparison women (CW) when hungry (after a 16-h fast) and after a meal...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28769072/post-conventional-moral-reasoning-is-associated-with-increased-ventral-striatal-activity-at-rest-and-during-task
#9
Zhuo Fang, Wi Hoon Jung, Marc Korczykowski, Lijuan Luo, Kristin Prehn, Sihua Xu, John A Detre, Joseph W Kable, Diana C Robertson, Hengyi Rao
People vary considerably in moral reasoning. According to Kohlberg's theory, individuals who reach the highest level of post-conventional moral reasoning judge moral issues based on deeper principles and shared ideals rather than self-interest or adherence to laws and rules. Recent research has suggested the involvement of the brain's frontostriatal reward system in moral judgments and prosocial behaviors. However, it remains unknown whether moral reasoning level is associated with differences in reward system function...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28765286/long-delay-arterial-spin-labeling-provides-more-accurate-cerebral-blood-flow-measurements-in-moyamoya-patients-a-simultaneous-positron-emission-tomography-mri-study
#10
Audrey P Fan, Jia Guo, Mohammad M Khalighi, Praveen K Gulaka, Bin Shen, Jun Hyung Park, Harsh Gandhi, Dawn Holley, Omar Rutledge, Prachi Singh, Tom Haywood, Gary K Steinberg, Frederick T Chin, Greg Zaharchuk
BACKGROUND AND PURPOSE: Arterial spin labeling (ASL) MRI is a promising, noninvasive technique to image cerebral blood flow (CBF) but is difficult to use in cerebrovascular patients with abnormal, long arterial transit times through collateral pathways. To be clinically adopted, ASL must first be optimized and validated against a reference standard in these challenging patient cases. METHODS: We compared standard-delay ASL (post-label delay=2.025 seconds), multidelay ASL (post-label delay=0...
August 1, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28754270/fast-acceleration-of-asl-based-time-resolved-magnetic-resonance-angiography-by-acquisition-of-control-and-labeled-images-in-the-same-shot-fast-actress-an-optimization-study
#11
Hiroyuki Sugimori, Noriyuki Fujima, Yuriko Suzuki, Hiroyuki Hamaguchi, Kinya Ishizaka, Kohsuke Kudo
PURPOSE: To establish an optimized sequence design for fast acceleration of arterial spin labeling (ASL)-based time-resolved magnetic resonance angiography (MRA) by acquisition of control and labeled images in the same shot (fast ACTRESS) and a scan time of <1min, for the evaluation of intracranial vessels. MATERIALS AND METHODS: Ten healthy volunteers with no unilateral symptomatic arterial stenosis, who underwent 3-tesla MRI, were investigated. Imaging parameters for the fast ACTRESS sequence were set with an acquisition time of 45s...
July 25, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28752225/grading-and-outcome-prediction-of-pediatric-diffuse-astrocytic-tumors-with-diffusion-and-arterial-spin-labeling-perfusion-mri-in-comparison-with-18f-dopa-pet
#12
Giovanni Morana, Arnoldo Piccardo, Domenico Tortora, Matteo Puntoni, Mariasavina Severino, Paolo Nozza, Marcello Ravegnani, Alessandro Consales, Samantha Mascelli, Alessandro Raso, Manlio Cabria, Antonio Verrico, Claudia Milanaccio, Andrea Rossi
PURPOSE: The aim of this study was to investigate MRI-derived diffusion weighted imaging (DWI) and arterial spin labeling (ASL) perfusion imaging in comparison with (18)F-dihydroxyphenylalanine (DOPA) PET with respect to diagnostic performance in tumor grading and outcome prediction in pediatric patients with diffuse astrocytic tumors (DAT). METHODS: We retrospectively analyzed 26 children with histologically proven treatment naïve low and high grade DAT who underwent ASL and DWI performed within 2 weeks of (18)F-DOPA PET...
July 27, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28750494/brain-pet-and-functional-mri-why-simultaneously-using-hybrid-pet-mr-systems
#13
Diego Cecchin, Alessandro Palombit, Marco Castellaro, Erica Silvestri, Franco Bui, Henryk Barthel, Osama Sabri, Maurizio Corbetta, Alessandra Bertoldo
INTRODUCTION: In the last 20 years growing attention has been devoted to multimodal imaging. The recent literature is rich of clinical and research studies that have been performed using different imaging modalities on both separate and integrated Positron Emission Tomography (PET) and Magnetic Resonance (MR) scanners. However, today, hybrid PET/MR systems measure signals related to brain structure, metabolism, neurochemistry, perfusion, and neuronal activity simultaneously, i.e. in the same physiological conditions...
July 27, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28738690/magnetic-resonance-imaging-in-children-presenting-migraine-with-aura-association-of-hypoperfusion-detected-by-arterial-spin-labelling-and-vasospasm-on-mr-angiography-findings
#14
Domitille Cadiot, Romain Longuet, Bertrand Bruneau, Catherine Treguier, Aline Carsin-Vu, Isabelle Corouge, Constantin Gomes, Maïa Proisy
Objective A child presenting with a first attack of migraine with aura usually undergoes magnetic resonance imaging (MRI) to rule out stroke. The purpose of this study was to report vascular and brain perfusion findings in children suffering from migraine with aura on time-of-flight MR angiography (TOF-MRA) and MR perfusion imaging using arterial spin labelling (ASL). Methods We retrospectively included all children who had undergone an emergency MRI examination with ASL and TOF-MRA sequences for acute neurological deficit and were given a final diagnosis of migraine with aura...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28737289/comparison-of-pasl-pcasl-and-background-suppressed-3d-pcasl-in-mild-cognitive-impairment
#15
Sudipto Dolui, Marta Vidorreta, Ze Wang, Ilya M Nasrallah, Abass Alavi, David A Wolk, John A Detre
We compared three implementations of single-shot arterial spin labeled (ASL) perfusion magnetic resonance imaging: two-dimensional (2D) pulsed ASL (PASL), 2D pseudocontinuous ASL (PCASL), and background-suppressed (BS) 3D PCASL obtained in a cohort of patients with mild cognitive impairment (MCI) and elderly controls. Study subjects also underwent (18) F-fluorodeoxyglucose positron emission tomography ((18) F-FDG PET). While BS 3D PCASL showed the lowest (P < 0.001) gray matter-white matter cerebral blood flow (CBF) contrast ratio, it provided the highest (P < 0...
July 24, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28736949/simultaneous-measurement-of-brain-perfusion-and-labeling-efficiency-in-a-single-pseudo-continuous-arterial-spin-labeling-scan
#16
Zhensen Chen, Xihai Zhao, Xingxing Zhang, Rui Guo, Wouter M Teeuwisse, Bida Zhang, Peter Koken, Jouke Smink, Chun Yuan, Matthias J P van Osch
PURPOSE: The aim of this study was to propose, optimize, and validate a pseudo-continuous arterial spin labeling (pCASL) sequence for simultaneous measurement of brain perfusion and labeling efficiency. METHODS: The proposed sequence incorporates the labeling efficiency measurement into the postlabeling delay period of a conventional perfusion pCASL sequence by using the time-encoding approach. In vivo validation experiments were performed on nine young subjects by comparing it to separate perfusion and labeling efficiency sequences...
July 24, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28736310/non-bold-contrast-for-laminar-fmri-in-humans-cbf-cbv-and-cmro2
#17
REVIEW
Laurentius Huber, Kâmil Uludağ, Harald E Möller
Functional magnetic resonance imaging (fMRI) using the blood oxygenation level-dependent (BOLD) contrast indirectly probes neuronal activity changes via evoked cerebral blood flow (CBF), cerebral blood volume (CBV) and cerebral metabolic rate of oxygen (CMRO2) changes. The gradient-echo BOLD signal is mostly sensitive to ascending veins in the tissue and to pial veins. Thereby, the achievable spatial specificity to neuronal activation is limited. Furthermore, the non-linear interaction of CBF, CBV and CMRO2 can hamper quantitative interpretations of the BOLD signal across cortical depths with different baseline physiology...
July 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28732352/cerebral-blood-flow-changes-in-remitted-early-and-late-onset-depression-patients
#18
Wenxiang Liao, Ze Wang, Xiangrong Zhang, Hao Shu, Zan Wang, Duan Liu, Zhijun Zhang
Abnormal cerebral blood flow (CBF) is reportedly associated with major depressive disorder (MDD). We have investigated CBF changes in early-onset depression (EOD) and late-onset depression (LOD), and their impact on cognitive function. Thirty-two remitted EOD patients, 32 remitted LOD patients, and 43 age-matched healthy controls were recruited, and the pulsed arterial spin labeling data were scanned under 3.0T MRI and processed through voxel-by-voxel statistical analysis. Compared to healthy controls, LOD patients had decreased normalized CBF in the bilateral precuneus, cuneus, right fronto-cingulate-striatal areas, and right temporal, occipital and parietal lobes, but increased normalized CBF in the left frontal and temporal cortices and the cingulate gyrus...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732091/perfusion-of-surgical-cavity-wall-enhancement-in-early-post-treatment-mr-imaging-may-stratify-the-time-to-progression-in-glioblastoma
#19
Ji Eun Park, Kyoung Hwa Ryu, Ho Sung Kim, Hyo Won Kim, Woo Hyun Shim, Seung Chai Jung, Choong Gon Choi, Sang Joon Kim, Jeong Hoon Kim
OBJECTIVE: To determine if perfusion in surgical cavity wall enhancement (SCWE) obtained in early post-treatment MR imaging can stratify time-to-progression (TTP) in glioblastoma. MATERIALS AND METHODS: This study enrolled 60 glioblastoma patients with more than 5-mm-thick SCWEs as detected on contrast-enhanced MR imaging after concurrent chemoradiation therapy. Two independent readers categorized the shape and perfusion state of SCWEs as nodular or non-nodular and as having positive or negative perfusion compared with the contralateral grey matter on arterial spin labeling (ASL)...
2017: PloS One
https://www.readbyqxmd.com/read/28729293/3d-pseudocontinuous-arterial-spin-labeling-mr-imaging-in-the-preoperative-evaluation-of-gliomas
#20
Q Zeng, B Jiang, F Shi, C Ling, F Dong, J Zhang
BACKGROUND AND PURPOSE: Previous studies showed conflicting results concerning the value of CBF maps obtained from arterial spin-labeling MR imaging in grading gliomas. This study was performed to investigate the effectiveness of CBF maps derived from 3D pseudocontinuous arterial spin-labeling in preoperatively assessing the grade, cellular proliferation, and prognosis of gliomas. MATERIALS AND METHODS: Fifty-eight patients with pathologically confirmed gliomas underwent preoperative 3D pseudocontinuous arterial spin-labeling...
July 20, 2017: AJNR. American Journal of Neuroradiology
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