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Arterial spin label

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https://www.readbyqxmd.com/read/28713328/recovery-from-unrecognized-sleep-loss-accumulated-in-daily-life-improved-mood-regulation-via-prefrontal-suppression-of-amygdala-activity
#1
Yuki Motomura, Shingo Kitamura, Kyoko Nakazaki, Kentaro Oba, Ruri Katsunuma, Yuri Terasawa, Akiko Hida, Yoshiya Moriguchi, Kazuo Mishima
Many modern people suffer from sleep debt that has accumulated in everyday life but is not subjectively noticed [potential sleep debt (PSD)]. Our hypothesis for this study was that resolution of PSD through sleep extension optimizes mood regulation by altering the functional connectivity between the amygdala and prefrontal cortex. Fifteen healthy male participants underwent an experiment consisting of a baseline (BL) evaluation followed by two successive interventions, namely, a 9-day sleep extension followed by one night of total sleep deprivation (TSD)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28712063/resisting-sleep-pressure-impact-on-resting-state-functional-network-connectivity
#2
Laura Tüshaus, Joshua Henk Balsters, Anthony Schläpfer, Daniel Brandeis, Ruth O'Gorman Tuura, Peter Achermann
In today's 24/7 society, sleep restriction is a common phenomenon which leads to increased levels of sleep pressure in daily life. However, the magnitude and extent of impairment of brain functioning due to increased sleep pressure is still not completely understood. Resting state network (RSN) analyses have become increasingly popular because they allow us to investigate brain activity patterns in the absence of a specific task and to identify changes under different levels of vigilance (e.g. due to increased sleep pressure)...
July 15, 2017: Brain Topography
https://www.readbyqxmd.com/read/28711813/multi-site-exploration-of-sex-differences-in-brain-reactivity-to-smoking-cues-consensus-across-sites-and-methodologies
#3
Kelly M Dumais, Teresa R Franklin, Kanchana Jagannathan, Nathan Hager, Michael Gawrysiak, Jennifer Betts, Stacey Farmer, Emily Guthier, Heather Pater, Amy C Janes, Reagan R Wetherill
BACKGROUND: Biological sex influences cigarette smoking behavior. More men than women smoke, but women have a harder time quitting. Sex differences in smoking cue (SC) reactivity may underlie such behavioral differences. However, the influence of sex on brain reactivity to SCs has yielded inconsistent findings suggesting the need for continued study. Here, we investigated the effect of sex on SC reactivity across two sites using different imaging modalities and SC stimulus types. METHODS: Pseudo-continuous arterial spin-labeled (pCASL) perfusion functional magnetic resonance imaging (fMRI) was used to assess brain responses to SC versus non-SC videos in 40 smokers (23 females) at the University of Pennsylvania...
July 8, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28711736/two-dose-investigation-of-the-5-ht-agonist-psilocybin-on-relative-and-global-cerebral-blood-flow
#4
Candace R Lewis, Katrin H Preller, Rainer Kraehenmann, Lars Michels, Philipp Stämpfli, Franz X Vollenweider
Psilocybin, the active compound in psychedelic mushrooms, is an agonist of various serotonin receptors. Seminal psilocybin positron emission tomography (PET) research suggested regional increases in glucose metabolism in frontal cortex (hyperfrontality). However, a recent arterial spin labeling (ASL) study suggests psilocybin may lead to hypo-perfusion in various brain regions. In this placebo-controlled, double-blind study we used pseudo-continuous ASL (pCASL) to measure perfusion changes, with and without adjustment for global brain perfusion, after two doses of oral psilocybin (low dose: 0...
July 12, 2017: NeuroImage
https://www.readbyqxmd.com/read/28708731/noncontrast-hybrid-arterial-spin-labeled-imaging-of-the-intracranial-arteries
#5
Ruth P Lim, Elena Trajcevska, Farah Al Rawi, Dinesh Gooneratne, Windell Ang, Yuliya Perchyonok, Gregory Fitt, Andrew Kemp, Shivraman Giri, Davide Piccini, Amy Brodtmann, Helen Dewey, Ioannis Koktzoglou
OBJECTIVE: The purpose of this study is to evaluate feasibility, image quality (IQ), and accuracy of noncontrast hybrid arterial spin labeling (NoHASL) magnetic resonance angiography (MRA) compared with time of flight (TOF) MRA and contrast-enhanced (CE) MRA in patients with known/suspected cerebrovascular ischemia. METHODS: Thirty inpatients were imaged at 1.5 T. Two neuroradiologists assessed 630 intracranial arterial segments for IQ (1, nondiagnostic; 3, satisfactory for diagnosis; and 5, excellent)...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28708726/measuring-cerebral-hypoperfusion-induced-by-hyperventilation-challenge-with-intravoxel-incoherent-motion-magnetic-resonance-imaging-in-healthy-volunteers
#6
Aude Pavilla, Alessandro Arrigo, Mehdi Mejdoubi, Régis Duvauferrier, Giulio Gambarota, Hervé Saint-Jalmes
OBJECTIVES: The aim of this study was to demonstrate the feasibility to assess cerebral hypoperfusion with a hyperventilation (HV) challenge protocol using intravoxel incoherent motion (IVIM) magnetic resonance imaging. MATERIALS AND METHODS: Magnetic resonance imaging experiments were performed on 10 healthy volunteers at 1.5 T, with a diffusion IVIM magnetic resonance imaging protocol using a set of b-values optimized by Cramer-Rao Lower Bound analysis. Hypoperfusion was induced by an HV maneuver...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28708304/hyperpolarized-13-c-magnetic-resonance-evaluation-of-renal-ischemia-reperfusion-injury-in-a-murine-model
#7
Celine Baligand, Hecong Qin, Aisha True-Yasaki, Jeremy W Gordon, Cornelius von Morze, Justin Delos Santos, David M Wilson, Robert Raffai, Patrick M Cowley, Anthony J Baker, John Kurhanewicz, David H Lovett, Zhen Jane Wang
Acute kidney injury (AKI) is a major risk factor for the development of chronic kidney disease (CKD). Persistent oxidative stress and mitochondrial dysfunction are implicated across diverse forms of AKI and in the transition to CKD. In this study, we applied hyperpolarized (HP) (13) C dehydroascorbate (DHA) and (13) C pyruvate magnetic resonance spectroscopy (MRS) to investigate the renal redox capacity and mitochondrial pyruvate dehydrogenase (PDH) activity, respectively, in a murine model of AKI at baseline and 7 days after unilateral ischemia reperfusion injury (IRI)...
July 14, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28705823/transient-focal-neurologic-symptoms-correspond-to-regional-cerebral-hypoperfusion-by-mri-a-stroke-mimic-in-children
#8
L L Lehman, A R Danehy, C C Trenor, C F Calahan, M E Bernson-Leung, R L Robertson, M J Rivkin
Children who present with acute transient focal neurologic symptoms raise concern for stroke or transient ischemic attack. We present a series of 16 children who presented with transient focal neurologic symptoms that raised concern for acute stroke but who had no evidence of infarction and had unilateral, potentially reversible imaging features on vascular and perfusion-sensitive brain MR imaging. Patients were examined with routine brain MR imaging, MRA, perfusion-sensitive sequences, and DWI. Fourteen (88%) children had lateralized MRA evidence of arterial tree pruning without occlusion, all had negative DWI findings, and all showed evidence of hemispheric hypoperfusion by susceptibility-weighted imaging or arterial spin-labeling perfusion imaging at presentation...
July 13, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28701991/an-arterial-spin-labeling-mri-perfusion-study-of-migraine-without-aura-attacks
#9
Raquel Gil-Gouveia, Joana Pinto, Patricia Figueiredo, Pedro Ferro Vilela, Isabel Pavão Martins
BACKGROUND: Studies of brain perfusion during migraine without aura attacks have inconsistent results. METHODS: Arterial spin labeling MRI, a non-invasive quantitative perfusion technique, was used to prospectively study a spontaneous untreated migraine without aura attack and a headache-free period. Image analysis used FSL and MATLAB software; Group analysis used permutation methods for perfusion differences between sessions. RESULTS: Thirteen women (age 35...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28691308/assessment-of-hypertensive-cerebrovascular-alterations-with-multiband-look-locker-arterial-spin-labeling
#10
Yoojin Lee, Tae Kim
PURPOSE: To quantitatively assess the hypertension-induced cerebrovascular alterations by measuring the dynamics of arterial spin labeling (ASL) signals. MATERIALS AND METHODS: The multiband Look-Locker ASL (MB LL-ASL) technique was evaluated in comparison to a single-band LL-ASL for three healthy subjects. Also, seven healthy subjects were scanned to determine the strength of the vascular crushing gradients applied to separate arterial from tissue ASL signal. With the optimized MB LL-ASL technique, multiple parameters, cerebral blood flow (CBF), transit times to artery (tA ), and capillary (tC ), delivery duration of labeled blood (τ), and arterial blood volume (CBVa ), were simultaneously quantified for age-matched eight control and eight hypertensive subjects with 259 msec of temporal resolution and 20 slices covering the whole-brain region at 3T...
July 10, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28689257/fluid-attenuated-inversion-recovery-vascular-hyperintensities-in-predicting-cerebral-hyperperfusion-after-intracranial-arterial-stenting
#11
Chih-Cheng Wan, David Yen-Ting Chen, Ying-Chi Tseng, Feng-Xian Yan, Kun-Yu Lee, Chen-Hua Chiang, Chi-Jen Chen
PURPOSE: No reliable imaging sign predicting cerebral hyperperfusion after intracranial arterial stenting (IAS) had been described in the literature. This study evaluated the effect of fluid-attenuated inversion recovery vascular hyperintensities (FVHs), also called hyperintense vessel sign on T2-weighted fluid-attenuated inversion recovery (T2-FLAIR) MR images, in predicting significant increase in cerebral blood flow (CBF) defined by arterial spin labeling (ASL) after IAS. METHODS: We reviewed ASL CBF images and T2-FLAIR MR images before (D0), 1 day after (D1), and 3 days after (D3) IAS of 16 patients...
July 8, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28687688/contribution-of-arterial-spin-labelling-mri-in-a-case-with-immune-reconstitution-inflammatory-syndrome
#12
Noriaki Wada, Tomoyuki Noguchi, Takahiro Aoki, Tsuyoshi Tajima
Central nervous system immune reconstitution inflammatory syndrome (CNS-IRIS), which occurs most often in HIV-infected patients, is an exacerbation of inflammatory reactions related to opportunistic infections as well as primary CNS malignancies both of which mostly occur in HIV-infected patients. However, differential diagnoses are challenging both clinically and radiologically. We describe a patient with CNS-IRIS due to toxoplasmosis whose (11)C-methionine uptake suggested lymphoma but whose arterial spin-labelling MRI led to the correct diagnosis...
July 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28681479/enhancement-of-automated-blood-flow-estimates-enable-from-arterial-spin-labeled-mri
#13
Zahra Shirzadi, Bojana Stefanovic, Michael A Chappell, Joel Ramirez, Graeme Schwindt, Mario Masellis, Sandra E Black, Bradley J MacIntosh
PURPOSE: To validate a multiparametric automated algorithm-ENhancement of Automated Blood fLow Estimates (ENABLE)-that identifies useful and poor arterial spin-labeled (ASL) difference images in multiple postlabeling delay (PLD) acquisitions and thereby improve clinical ASL. MATERIALS AND METHODS: ENABLE is a sort/check algorithm that uses a linear combination of ASL quality features. ENABLE uses simulations to determine quality weighting factors based on an unconstrained nonlinear optimization...
July 6, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28678737/functional-brain-mri-in-patients-complaining-of-electrohypersensitivity-after-long-term-exposure-to-electromagnetic-fields
#14
Gunnar Heuser, Sylvia A Heuser
INTRODUCTION: Ten adult patients with electromagnetic hypersensitivity underwent functional magnetic resonance imaging (fMRI) brain scans. All scans were abnormal with abnormalities which were consistent and similar. It is proposed that fMRI brain scans be used as a diagnostic aid for determining whether or not a patient has electromagnetic hypersensitivity. Over the years we have seen an increasing number of patients who had developed multi system complaints after long term repeated exposure to electromagnetic fields (EMFs)...
July 5, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28673449/arterial-spin-labelling-mri-for-detecting-pseudocapsule-defects-and-predicting-renal-capsule-invasion-in-renal-cell-carcinoma
#15
H Zhang, Y Wu, W Xue, P Zuo, N Oesingmann, Q Gan, Z Huang, M Wu, F Hu, M Kuang, B Song
AIM: To evaluate prospectively the performance of combining morphological and arterial spin labelling (ASL) magnetic resonance imaging (MRI) for detecting pseudocapsule defects in renal cell carcinoma (RCC), and to predict renal capsule invasion confirmed histopathologically. MATERIALS AND METHODS: Twenty consecutive patients with suspicious renal tumours underwent MRI. Renal ASL imaging was performed and renal blood flow was measured quantitatively. The diagnostic performance of T2-weighted images alone, and a combination of T2-weighted and ASL images for predicting renal capsule invasion were assessed...
June 30, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28668343/changes-in-arterial-cerebral-blood-volume-during-lower-body-negative-pressure-measured-with-mri
#16
Joseph R Whittaker, Molly G Bright, Ian D Driver, Adele Babic, Sharmila Khot, Kevin Murphy
Cerebral Autoregulation (CA), defined as the ability of the cerebral vasculature to maintain stable levels of blood flow despite changes in systemic blood pressure, is a critical factor in neurophysiological health. Magnetic resonance imaging (MRI) is a powerful technique for investigating cerebrovascular function, offering high spatial resolution and wide fields of view (FOV), yet it is relatively underutilized as a tool for assessment of CA. The aim of this study was to demonstrate the potential of using MRI to measure changes in cerebrovascular resistance in response to lower body negative pressure (LBNP)...
June 28, 2017: NeuroImage
https://www.readbyqxmd.com/read/28665168/cerebral-hyperperfusion-on-arterial-spin-labeling-mri-after-reperfusion-therapy-is-related-to-hemorrhagic-transformation
#17
Shuhei Okazaki, Hiroshi Yamagami, Takeshi Yoshimoto, Yoshiaki Morita, Haruko Yamamoto, Kazunori Toyoda, Masafumi Ihara
Early detection of hemorrhagic transformation after reperfusion therapy is crucial in acute stroke treatment. Here, we evaluated the relationship between hemorrhagic transformation and post-reperfusion hyperperfusion using pulsed arterial spin labeling (ASL) perfusion MRI and (123)I-iodoamphetamine single-photon emission-computed tomography. Patients who developed hemorrhagic transformation showed significantly higher cerebral blood flow in the affected lesion after thrombolysis and/or endovascular intervention...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28659787/better-correlation-of-cognitive-function-to-white-matter-integrity-than-to-blood-supply-in-subjects-with-leukoaraiosis
#18
Genlong Zhong, Ruiting Zhang, Yerfan Jiaerken, Xinfeng Yu, Ying Zhou, Chang Liu, Longting Lin, Lusha Tong, Min Lou
Leukoaraiosis is associated with increased risk of cognitive impairment, but its pathophysiological pathway is unclear. The aim of the present study was to determine whether brain structural damage or cerebral blood supply better correlated with the global cognitive outcome in subjects with leukoaraiosis. Seventy-five subjects with leukoaraiosis were included in present study, with age ranged from 43 to 85 years, with mean white matter hyperintensities (WMH) volume 30.69 ± 24.35 mL. Among them, 19(25.33%) subjects presented with cerebral microbleeds (CMB) and 40 (53...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28653470/characterization-of-pseudo-continuous-arterial-spin-labeling-simulations-and-experimental-validation
#19
Kathrin Lorenz, Toralf Mildner, Torsten Schlumm, Harald E Möller
PURPOSE: To characterize pseudo-continuous arterial spin labeling (pCASL) through simulations of spin inversion and to discuss suitable parameter settings for measuring cerebral perfusion. METHODS: Simulations of arterial spin inversion in pCASL were performed based on the Bloch equation. Both the labeling and the control condition of pCASL were analyzed separately, and the labeling efficiency, α, was calculated depending on the averages of both, the radiofrequency (RF) field amplitude and labeling gradient strength...
June 26, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28652290/imaging-pain-relief-in-osteoarthritis-ipro-protocol-of-a-double-blind-randomised-controlled-mechanistic-study-assessing-pain-relief-and-prediction-of-duloxetine-treatment-outcome
#20
Diane Reckziegel, Helen Bailey, William J Cottam, Christopher R Tench, Ravi P Mahajan, David A Walsh, Roger D Knaggs, Dorothee P Auer
INTRODUCTION: Osteoarthritis (OA) pain is a major cause of long-term disability and chronic pain in the adult population. One in five patients does not receive satisfactory pain relief, which reflects the complexity of chronic pain and the current lack of understanding of mechanisms of chronic pain. Recently, duloxetine has demonstrated clinically relevant pain relief, but only in half of treated patients with OA. Here, the aim is to investigate the neural mechanisms of pain relief and neural signatures that may predict treatment response to duloxetine in chronic knee OA pain...
June 26, 2017: BMJ Open
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