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Arterial spin label

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https://www.readbyqxmd.com/read/29629988/early-evidence-of-sepsis-associated-hyperperfusion-a-study-of-cerebral-blood-flow-measured-with-mri-arterial-spin-labeling-in-critically-ill-septic-patients-and-control-subjects
#1
Marie-Hélène Masse, Marie Anne Richard, Frédérick D'Aragon, Charles St-Arnaud, Michael Mayette, Neill K J Adhikari, William Fraser, André Carpentier, Steven Palanchuck, David Gauthier, Luc Lanthier, Matthieu Touchette, Albert Lamontagne, Jean Chénard, Sangeeta Mehta, Yanick Sansoucy, Etienne Croteau, Martin Lepage, François Lamontagne
OBJECTIVES: Mechanisms underlying sepsis-associated encephalopathy remain unclear, but reduced cerebral blood flow, alone or in conjunction with altered autoregulation, is reported as a potential contributor. We compared cerebral blood flow of control subjects and vasopressor-dependent septic patients. DESIGN: Randomized crossover study. SETTING: MRI with arterial spin labeling. PATIENTS: Ten sedated septic patients on mechanical ventilation (four with controlled chronic hypertension) and 12 control subjects (six with controlled chronic hypertension) were enrolled...
April 6, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29620513/reliability-of-three-dimentional-pseudo-continuous-arterial-spin-labeling-a-volumetric-cerebral-perfusion-imaging-with-different-post-labeling-time-and-functional-state-in-health-adults
#2
Meng-Qi Liu, Zhi-Ye Chen, Lin Ma
Objective To evaluate the reliability of three dimensional spiral fast spin echo pseudo-continuous arterial spin labeling (3D pc-ASL) in measuring cerebral blood flow (CBF) with different post-labeling delay time (PLD) in the resting state and the right finger taping state. Methods 3D pc-ASL and three dimensional T1-weighted fast spoiled gradient recalled echo (3D T1-FSPGR) sequence were applied to eight healthy subjects twice at the same time each day for one week interval. ASL data acquisition was performed with post-labeling delay time (PLD) 1...
March 30, 2018: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/29619520/differentiation-between-primary-cns-lymphoma-and-glioblastoma-qualitative-and-quantitative-analysis-using-arterial-spin-labeling-mr-imaging
#3
Sung-Hye You, Tae Jin Yun, Hye Jeong Choi, Roh-Eul Yoo, Koung Mi Kang, Seung Hong Choi, Ji-Hoon Kim, Chul-Ho Sohn
OBJECTIVES: To evaluate the diagnostic performance of arterial spin labelling perfusion weighted images (ASL-PWIs) to differentiate primary CNS lymphoma (PCNSL) from glioblastoma (GBM). METHODS: ASL-PWIs of pathologically confirmed PCNSL (n = 21) or GBM (n = 93) were analysed. For qualitative analysis, tumours were visually scored into five categories based on ASL-CBF maps. For quantitative analysis, normalised CBF values were derived by contralateral grey matter (GM) in intra- and peritumoral areas (nCBFintratumoral and nCBFperitumoral , respectively)...
April 4, 2018: European Radiology
https://www.readbyqxmd.com/read/29618992/fronto-temporal-connectivity-predicts-ect-outcome-in-major-depression
#4
Amber M Leaver, Benjamin Wade, Megha Vasavada, Gerhard Hellemann, Shantanu H Joshi, Randall Espinoza, Katherine L Narr
Background: Electroconvulsive therapy (ECT) is arguably the most effective available treatment for severe depression. Recent studies have used MRI data to predict clinical outcome to ECT and other antidepressant therapies. One challenge facing such studies is selecting from among the many available metrics, which characterize complementary and sometimes non-overlapping aspects of brain function and connectomics. Here, we assessed the ability of aggregated, functional MRI metrics of basal brain activity and connectivity to predict antidepressant response to ECT using machine learning...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29609518/vascular-abnormalities-within-normal-appearing-tissue-in-chronic-traumatic-brain-injury
#5
Margalit Haber, Franck Amyot, Kimbra Kenney, Tawny Meredith-Duliba, Carol Moore, Erika Silverman, Jamie Podell, Yi-Yu Chou, Dzung L Pham, John Butman, Hanzang Lu, Ramon Diaz-Arrastia, Danielle Sandsmark
Magnetic resonance imaging (MRI) is a powerful tool for visualizing traumatic brain injury(TBI)-related lesions. Trauma-induced encephalomalacia is frequently identified by its hyperintense appearance on fluid-attenuated inversion recovery (FLAIR) sequences. In addition to parenchymal lesions, TBI commonly results in cerebral microvascular injury, but its anatomic relationship to parenchymal encephalomalacia is not well characterized. The current study utilized a multimodal MRI protocol to assess microstructural tissue integrity [via mean diffusivity (MD) and fractional aniosotropy (FA)], and altered vascular function [via cerebral blood flow (CBF) and cerebral vascular reactivity (CVR)], within regions of visible encephalomalacia and normal appearing tissue in 27 chronic TBI (minimum 6 months after injury) subjects...
April 2, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29604324/effect-of-blood-t1-estimation-strategy-on-arterial-spin-labeled-cerebral-blood-flow-quantification-in-children-and-young-adults-with-kidney-disease
#6
Hua-Shan Liu, Abbas F Jawad, Nina Laney, Erum A Hartung, Susan L Furth, John A Detre
PURPOSE: To compare blood T1 estimation approaches used for quantifying cerebral blood flow (CBF) with arterial spin labeled (ASL) perfusion MRI in a developmental cohort of chronic kidney disease (CKD) patients with anemia and a control group. METHODS: 61 patients with CKD and 47 age-matched control subjects were studied. Blood T1 approaches included: (1) a fixed value, (2) estimation based on measured hematocrit (Hct), and (3) estimation based on Age+Sex using a published formula...
March 28, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29601112/cerebral-perfusion-characteristics-show-differences-in-younger-versus-older-children-with-sickle-cell-anaemia-results-from-a-multiple-inflow-time-arterial-spin-labelling-study
#7
Jamie M Kawadler, Patrick W Hales, Simon Barker, Timothy C S Cox, Fenella J Kirkham, Chris A Clark
Sickle cell anaemia (SCA) is associated with chronic anaemia and oxygen desaturation, which elevate cerebral blood flow (CBF) and increase the risk of neurocognitive complications. Arterial spin labelling (ASL) provides a methodology for measuring CBF non-invasively; however, ASL techniques using only a single inflow time are not sufficient to fully characterize abnormal haemodynamic behaviour in SCA. This study investigated haemodynamic parameters from a multi-inflow-time ASL acquisition in younger (8-12 years) and older (13-18 years) children with SCA with and without silent cerebral infarction (SCI+/-) (n = 20 and 19 respectively, 6 and 4 SCI+ respectively) and healthy controls (n = 9 and 7 respectively)...
March 30, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29600511/increased-cerebral-blood-flow-on-arterial-spin-labeling-magnetic-resonance-imaging-can-localize-to-seizure-focus-in-newborns-a-report-of-3-cases
#8
Patrick Mabray, Rapeepat Thewamit, Matthew T Whitehead, Amy Kao, Joseph Scafidi, William D Gaillard, Taeun Chang, Tammy N Tsuchida
Arterial spin labeling (ASL) magnetic resonance imaging (MRI) can assess cerebral blood flow (CBF) without using radiolabeled tracers. It is unknown whether regional increases in CBF on ASL MRI correlate with seizure location in newborns. We report 3 newborns with focal seizures localized on continuous video electroencephalogram (cEEG), anatomical brain MRI, and ASL MRI. Each patient underwent pseudocontinuous ASL with segmented 3-dimensional fast spin echo readout as part of standard care. Case 1 is a term male infant presenting with left temporal status epilepticus and recurrent cEEG seizures from an idiopathic large left intraventricular hemorrhage...
March 30, 2018: Epilepsia
https://www.readbyqxmd.com/read/29593548/impact-of-nitric-oxide-bioavailability-on-the-progressive-cerebral-and-peripheral-circulatory-impairments-during-aging-and-alzheimer-s-disease
#9
Massimo Venturelli, Anna Pedrinolla, Ilaria Boscolo Galazzo, Cristina Fonte, Nicola Smania, Stefano Tamburin, Ettore Muti, Lucia Crispoltoni, Annamaria Stabile, Alessandra Pistilli, Mario Rende, Francesca B Pizzini, Federico Schena
Advanced aging, vascular dysfunction, and nitric oxide (NO) bioavailability are recognized risk factors for Alzheimer's disease (AD). However, the contribution of AD, per se , to this putative pathophysiological mechanism is still unclear. To better answer this point, we quantified cortical perfusion with arterial spin labeling (PVC-CBF), measured ultrasound internal carotid (ICA), and femoral (FA) artery blood flow in a group of patients with similar age (~78 years) but different cognitive impairment (i.e...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29582174/arterial-spin-labeling-perfusion-weighted-mr-imaging-correlation-of-tumor-blood-flow-with-pathological-degree-of-tumor-differentiation-clinical-stage-and-nodal-metastasis-of-head-and-neck-squamous-cell-carcinoma
#10
Ahmed Abdel Khalek Abdel Razek, Nadia Nada
PURPOSE: The prognostic parameters of head and neck squamous cell carcinoma (HNSCC) include the pathological degree of tumor differentiation, clinical staging, and presence of metastatic cervical lymph nodes. To correlate tumor blood flow (TBF) acquired from arterial spin labeling (ASL) perfusion-weighted MR imaging with pathological degree of tumor differentiation, clinical stage, and nodal metastasis of HNSCC. MATERIALS AND METHODS: Retrospective analysis of 43 patients (31 male, 12 female with a mean age of 65 years) with HNSCC that underwent ASL of head and neck and TBF of HNSCC was calculated...
March 27, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29580967/interleaved-quantitative-bold-combining-extravascular-r-2-and-intravascular-r-2-measurements-for-estimation-of-deoxygenated-blood-volume-and-hemoglobin-oxygen-saturation
#11
Hyunyeol Lee, Erin K Englund, Felix W Wehrli
Quantitative BOLD (qBOLD), a non-invasive MRI method for assessment of hemodynamic and metabolic properties of the brain in the baseline state, provides spatial maps of deoxygenated blood volume fraction (DBV) and hemoglobin oxygen saturation (HbO2 ) by means of an analytical model for the temporal evolution of free-induction-decay signals in the extravascular compartment. However, mutual coupling between DBV and HbO2 in the signal model results in considerable estimation uncertainty precluding achievement of a unique set of solutions...
March 23, 2018: NeuroImage
https://www.readbyqxmd.com/read/29577377/improved-calculation-of-the-equilibrium-magnetization-of-arterial-blood-in-arterial-spin-labeling
#12
André Ahlgren, Ronnie Wirestam, Linda Knutsson, Esben Thade Petersen
PURPOSE: To propose and assess an improved method for calculating the equilibrium magnetization of arterial blood ( M0a), used for calibration of perfusion estimates in arterial spin labeling. METHODS: Whereas standard M0a calculation is based on dividing a proton density-weighted image by an average brain-blood partition coefficient, the proposed method exploits partial-volume data to adjust this ratio. The nominator is redefined as the magnetization of perfused tissue, and the denominator is redefined as a weighted sum of tissue-specific partition coefficients...
March 25, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29575161/single-shot-spiral-imaging-at-7-t
#13
Maria Engel, Lars Kasper, Christoph Barmet, Thomas Schmid, Laetitia Vionnet, Bertram Wilm, Klaas P Pruessmann
PURPOSE: The purpose of this work is to explore the feasibility and performance of single-shot spiral MRI at 7 T, using an expanded signal model for reconstruction. METHODS: Gradient-echo brain imaging is performed on a 7 T system using high-resolution single-shot spiral readouts and half-shot spirals that perform dual-image acquisition after a single excitation. Image reconstruction is based on an expanded signal model including the encoding effects of coil sensitivity, static off-resonance, and magnetic field dynamics...
March 25, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29573085/radiomics-strategy-for-glioma-grading-using-texture-features-from-multiparametric-mri
#14
Qiang Tian, Lin-Feng Yan, Xi Zhang, Xin Zhang, Yu-Chuan Hu, Yu Han, Zhi-Cheng Liu, Hai-Yan Nan, Qian Sun, Ying-Zhi Sun, Yang Yang, Ying Yu, Jin Zhang, Bo Hu, Gang Xiao, Ping Chen, Shuai Tian, Jie Xu, Wen Wang, Guang-Bin Cui
BACKGROUND: Accurate glioma grading plays an important role in the clinical management of patients and is also the basis of molecular stratification nowadays. PURPOSE/HYPOTHESIS: To verify the superiority of radiomics features extracted from multiparametric MRI to glioma grading and evaluate the grading potential of different MRI sequences or parametric maps. STUDY TYPE: Retrospective; radiomics. POPULATION: A total of 153 patients including 42, 33, and 78 patients with Grades II, III, and IV gliomas, respectively...
March 23, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29572600/decreased-cerebral-blood-flow-in-mesial-thalamus-and-precuneus-pcc-during-midazolam-induced-sedation-assessed-with-asl
#15
Peipeng Liang, Yachao Xu, Fei Lan, Daqing Ma, Kuncheng Li
While some previous work suggests that midazolam-induced light sedation results from the functional disconnection within resting state network, little is known about the underlying alterations of cerebral blood flow (CBF) associated with its effects. A randomized, double-blind, within-subject, cross-over design was adopted, while 12 healthy young volunteers were scanned with arterial spin-labeling (ASL) perfusion MRI both before and after an injection of either saline or midazolam. The contrast of MRI signal before and after midazolam administration revealed the CBF decrease in the bilateral mesial thalamus and precuneus/posterior cingulate cortex (PCC)...
March 23, 2018: Neuroinformatics
https://www.readbyqxmd.com/read/29571799/measurement-of-pediatric-regional-cerebral-blood-flow-from-6-months-to-15-years-of-age-in-a-clinical-population
#16
Aline Carsin-Vu, Isabelle Corouge, Olivier Commowick, Guillaume Bouzillé, Christian Barillot, Jean-Christophe Ferré, Maia Proisy
OBJECTIVES: To investigate changes in cerebral blood flow (CBF) in gray matter (GM) between 6 months and 15 years of age and to provide CBF values for the brain, GM, white matter (WM), hemispheres and lobes. METHODS: Between 2013 and 2016, we retrospectively included all clinical MRI examinations with arterial spin labeling (ASL). We excluded subjects with a condition potentially affecting brain perfusion. For each subject, mean values of CBF in the brain, GM, WM, hemispheres and lobes were calculated...
April 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29559372/a-double-dissociation-between-two-psychotic-phenotypes-periodic-catatonia-and-cataphasia
#17
Foucher Jack René, Zhang Yi Fan, Roser Mathilde, Lamy Julien, De Sousa Paulo Loureiro, Weibel Sébastien, Vidailhet Pierre, Mainberger Olivier, Berna Fabrice
Schizophrenia as a single liability model was confronted to the multiple psychotic phenotypes model proposed by the Wernicke-Kleist-Leonhard school, focusing on two: periodic catatonia (PC) and cataphasia (C). Both are stable and heritable psychotic phenotypes with no crossed liability and are coming with the buildup of specific residual symptoms: impairment of psychomotricity for PC and a specific disorganization of thought and language in C. Regional cerebral blood flow (rCBF) was used as a biomarker. We attempted to refute the single phenotype model by looking at relevant and specific rCBF anomalies for PC and C, that would exceed anomalies in common relative to controls (CTR), i...
March 17, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29559018/%C3%AE-aminobutyric-acid-type-a-receptor-binding-affinity-in-the-right-inferior-frontal-gyrus-at-resting-state-predicts-the-performance-of-healthy-elderly-people-in-the-visual-sustained-attention-test
#18
Masato Kasagi, Tomokazu Motegi, Kosuke Narita, Kazuyuki Fujihara, Yusuke Suzuki, Minami Tagawa, Koichi Ujita, Hirotaka Shimada, Masato Fukuda
BACKGROUND: Although recent studies have suggested that the γ-aminobutyric acid type A (GABAA) receptor binding affinity can be a more sensitive marker of age-related neuronal loss than regional gray matter (GM) volume, knowledge about the relationship between decreased GABAA receptor binding affinity and cognitive decline during normal aging is still limited. METHODS: Thirty-seven healthy elderly individuals (aged 50-77 years (mean, 64.5 ± 7.3 years); 15 males and 22 females) were enrolled in this study...
March 21, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29551989/could-arterial-spin-labeling-distinguish-patients-in-minimally-conscious-state-from-patients-in-vegetative-state
#19
Bing Wu, Yi Yang, Shuai Zhou, Wei Wang, Zizhen Wang, Gang Hu, Jianghong He, Xinhuai Wu
Purpose: Diagnostic error is common among patients with vegetative state (VS) and minimally conscious state (MCS). The purpose of this article is to use three-dimensional pseudo-continuous arterial spin labeling (pcASL) to compare cerebral blood flow (CBF) patterns in patients in MCS with those in VS. Methods: Patients meeting MCS and VS criteria were identified. Two post-labeling delay (PLD) time pcASL on 3.0-Tesla magnetic resonance imaging scanner system were performed with patients in the resting awake state...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29551091/evaluation-of-skeletal-muscle-microvascular-perfusion-of-lower-extremities-by-cardiovascular-magnetic-resonance-arterial-spin-labeling-blood-oxygenation-level-dependent-and-intravoxel-incoherent-motion-techniques
#20
Shiteng Suo, Lan Zhang, Hui Tang, Qihong Ni, Suqin Li, Haimin Mao, Xiangyu Liu, Shengyun He, Jianxun Qu, Qing Lu, Jianrong Xu
BACKGROUND: Noninvasive cardiovascular magnetic resonance (CMR) techniques including arterial spin labeling (ASL), blood oxygenation level-dependent (BOLD), and intravoxel incoherent motion (IVIM), are capable of measuring tissue perfusion-related parameters. We sought to evaluate and compare these three CMR techniques in characterizing skeletal muscle perfusion in lower extremities and to investigate their abilities to diagnose and assess the severity of peripheral arterial disease (PAD)...
March 19, 2018: Journal of Cardiovascular Magnetic Resonance
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