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Arterial spin label

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https://www.readbyqxmd.com/read/27913820/cerebral-blood-flow-transit-time-and-apparent-diffusion-coefficient-in-moyamoya-disease-before-and-after-acetazolamide
#1
Christian Federau, Soren Christensen, Zungho Zun, Sun-Won Park, Wendy Ni, Michael Moseley, Greg Zaharchuk
INTRODUCTION: The goal of this study was to assess the changes in arterial spin labeling (ASL) cerebral blood flow (CBF) and arterial transit time (ATT), and in apparent diffusion coefficient (ADC), before and after an acetazolamide challenge in moyamoya patients, as function of arterial stenosis severity. METHODS: Pre-operative patients diagnosed with moyamoya disease who could undergo MRI at 3.0T were recruited for this study. A multi-delay pseudo-continuous ASL and a diffusion-weighted sequence were acquired before and 15 min after acetazolamide injection...
December 2, 2016: Neuroradiology
https://www.readbyqxmd.com/read/27911758/multimodal-imaging-for-dreadd-expressing-neurons-in-living-brain-and-their-application-to-implantation-of-ipsc-derived-neural-progenitors
#2
Bin Ji, Hiroyuki Kaneko, Takafumi Minamimoto, Haruhisa Inoue, Hiroki Takeuchi, Katsushi Kumata, Ming-Rong Zhang, Ichio Aoki, Chie Seki, Maiko Ono, Masaki Tokunaga, Satoshi Tsukamoto, Koji Tanabe, Ryong-Moon Shin, Takeharu Minamihisamatsu, Seiji Kito, Barry J Richmond, Tetsuya Suhara, Makoto Higuchi
: Chemogenetic manipulation of neuronal activities has been enabled by a designer receptor (designer receptor exclusively activated by designer drugs, DREADD) that is activated exclusively by clozapine-N-oxide (CNO). Here, we applied CNO as a functional reporter probe to positron emission tomography (PET) of DREADD in living brains. Mutant human M4 DREADD (hM4Di) expressed in transgenic (Tg) mouse neurons was visualized by PET with microdose [(11)C]CNO. Deactivation of DREADD-expressing neurons in these mice by nonradioactive CNO at a pharmacological dose could also be captured by arterial spin labeling MRI (ASL-MRI)...
November 9, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27909202/prediction-of-blood-brain-barrier-disruption-and-intracerebral-hemorrhagic-infarction-using-arterial-spin-labeling-magnetic-resonance-imaging
#3
Takeya Niibo, Hajime Ohta, Shirou Miyata, Ichiro Ikushima, Kazuchika Yonenaga, Hideo Takeshima
BACKGROUND AND PURPOSE: Arterial spin-labeling magnetic resonance imaging is sensitive for detecting hyperemic lesions (HLs) in patients with acute ischemic stroke. We evaluated whether HLs could predict blood-brain barrier (BBB) disruption and hemorrhagic transformation (HT) in acute ischemic stroke patients. METHODS: In a retrospective study, arterial spin-labeling was performed within 6 hours of symptom onset before revascularization treatment in 25 patients with anterior circulation large vessel occlusion on baseline magnetic resonance angiography...
December 1, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27908711/cerebral-blood-flow-measured-by-arterial-spin-labeling-mri-at-resting-state-in-normal-aging-and-alzheimer-s-disease
#4
REVIEW
Nan Zhang, Marc L Gordon, Terry E Goldberg
Arterial spin labeling (ASL) magnetic resonance imaging uses arterial blood water as an endogenous tracer to measure cerebral blood flow (CBF). In this review, based on ASL studies in the resting state, we discuss state-of-the-art technical and data processing improvements in ASL, and ASL CBF changes in normal aging, mild cognitive impairment (MCI), Alzheimer's disease (AD), and other types of dementia. We propose that vascular and AD risk factors should be considered when evaluating CBF changes in aging, and that other validated biomarkers should be used as inclusion criteria or covariates when evaluating CBF changes in MCI and AD...
November 28, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27905100/the-severity-of-anaemia-depletes-cerebrovascular-dilatory-reserve-in-children-with-sickle-cell-disease-a-quantitative-magnetic-resonance-imaging-study
#5
Przemyslaw D Kosinski, Paula L Croal, Jackie Leung, Suzan Williams, Isaac Odame, Gregory M T Hare, Manohar Shroff, Andrea Kassner
Overt ischaemic stroke is one of the most devastating complications in children with sickle cell disease (SCD). The compensatory response to anaemia in SCD includes an increase in cerebral blood flow (CBF) by accessing cerebrovascular dilatory reserve. Exhaustion of dilatory reserve secondary to anaemic stress may lead to cerebral ischaemia. The purpose of this study was to investigate CBF and cerebrovascular reactivity (CVR) using magnetic resonance imaging (MRI) in children with SCD and to correlate these with haematological markers of anaemia...
December 1, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27902863/evaluation-of-recurrent-high-grade-gliomas-treated-with-bevacizumab-a-preliminary-report-of-3d-pseudocontinuous-artery-spin-labeling
#6
Yuelei Lyu, Shuai Liu, Hui You, Bo Hou, Yu Wang, Wenbin Ma, Feng Feng
PURPOSE: To investigate the role of cerebral blood flow (CBF) derived from a 3D fast spin echo (FSE) pseudocontinuous artery spin labeling (pcASL) sequence in evaluating the survival rate of recurrent high-grade gliomas (rHGGs) that were treated with bevacizumab (BEV). MATERIALS AND METHODS: Sixteen patients with rHGGs who underwent 3T 3D FSE pcASL imaging 1-2 days before (baseline or pre-BEV) and within 1 month after BEV treatment initiation (post-BEV) were included in the study...
November 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27898185/perfusion-has-no-effect-on-the-in-vivo-cest-effect-from-cr-crcest-in-skeletal-muscle
#7
Feliks Kogan, Randall B Stafford, Erin K Englund, Garry E Gold, Hari Hariharan, John A Detre, Ravinder Reddy
Creatine, a key component of muscle energy metabolism, exhibits a chemical exchange saturation transfer (CEST) effect between its amine group and bulk water, which has been exploited to spatially and temporally map creatine changes in skeletal muscle before and after exercise. In addition, exercise leads to an increase in muscle perfusion. In this work, we determined the effects of perfused blood on the CEST effects from creatine in skeletal muscle. Experiments were performed on healthy human subjects (n = 5) on a whole-body Siemens 7T magnetic resonance imaging (MRI) scanner with a 28-channel radiofrequency (RF) coil...
November 29, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27880813/transcranial-doppler-based-surrogates-for-cerebral-blood-flow-a-statistical-study
#8
Joseph Hart, Vera Novak, Charles Saunders, Pierre A Gremaud
It is commonly assumed that perfusion in a given cerebral territory can be inferred from Blood Flow Velocity (BFV) measurements in the corresponding stem artery. In order to test this hypothesis, we construct a cerebral blood flow (CBF) estimator based on transcranial Doppler (TCD) blood flow velocity and ten other easily available patient characteristics and clinical parameters. A total of 261 measurements were collected from 88 older patients. The estimator is based on local regression (Random Forest). Its performance is analyzed against baseline CBF from 3-D pseudocontinuous arterial spin labeling (pCASL) magnetic resonance imaging (MRI)...
2016: PloS One
https://www.readbyqxmd.com/read/27879446/quantification-of-serial-cerebral-blood-flow-in-acute-stroke-using-arterial-spin-labeling
#9
George W J Harston, Thomas W Okell, Fintan Sheerin, Ursula Schulz, Phil Mathieson, Ian Reckless, Kunal Shah, Gary A Ford, Michael A Chappell, Peter Jezzard, James Kennedy
BACKGROUND AND PURPOSE: Perfusion-weighted imaging is used to select patients with acute ischemic stroke for intervention, but knowledge of cerebral perfusion can also inform the understanding of ischemic injury. Arterial spin labeling allows repeated measurement of absolute cerebral blood flow (CBF) without the need for exogenous contrast. The aim of this study was to explore the relationship between dynamic CBF and tissue outcome in the month after stroke onset. METHODS: Patients with nonlacunar ischemic stroke underwent ≤5 repeated magnetic resonance imaging scans at presentation, 2 hours, 1 day, 1 week, and 1 month...
November 22, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27876012/phase-i-study-of-low-dose-metronomic-temozolomide-for-recurrent-malignant-gliomas
#10
Eric T Wong, Joshua Timmons, Amy Callahan, Lauren O'Loughlin, Bridget Giarusso, David C Alsop
BACKGROUND: The treatment goal for recurrent malignant gliomas centers on disease stabilization while minimizing therapy-related side effects. Metronomic dosing of cytotoxic chemotherapy has emerged as a promising option to achieve this objective. METHODS: This phase I study was performed using metronomic temozolomide (mTMZ) at 25 or 50 mg/m(2)/day continuously in 42-day cycles. Correlative studies were incorporated using arterial spin labeling MRI to assess tumor blood flow, analysis of matrix metalloproteinase-2 (MMP-2) and MMP-9 activities in the cerebrospinal fluid (CSF) as surrogates for tumor angiogenesis and invasion, as well as determination of CSF soluble interleukin-2 receptor alpha (sIL-2Rα) levels as a marker of immune modulation...
November 22, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27867814/the-assessment-of-myometrium-perfusion-in-patients-with-uterine-fibroid-by-arterial-spin-labeling-mri
#11
Nozomi Takahashi, Osamu Yoshino, Osamu Hiraike, Eriko Maeda, Masanobu Nakamura, Masaaki Hori, Miyuki Harada, Kaori Koga, Shigeru Saito, Tomoyuki Fujii, Yutaka Osuga
BACKGROUND: It has been suggested that an inadequate blood supply caused by uterine fibroids may lead to decreasing fertility. Therefore, a quantitative evaluation of blood flow in the uterus might be a good tool for infertility treatments. For the first step, the ability to perform arterial spin labeling (ASL)-MRI in pelvic organs was examined by measuring blood flow in the uterine muscle layer. RESULTS: Three normal volunteer women, seven patients with one uterine fibroid and four patients treated with GnRH analogue for uterine fibroids, were enrolled in this study...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27867170/evaluation-of-appropriate-readout-sequence-for-renal-mri-perfusion-using-astar-asl-technique
#12
Kyoko Takakura, Aki Kido, Koji Fujimoto, Kayo Kiguchi, Yasutaka Fushimi, Naotaka Sakashita, Tokunori Kimura, Kaori Togashi
The aim of this study was to compare true-steady state free precession (True-SSFP) with fast field echo (FFE) as readout imaging sequences for renal arterial spin labeling (ASL), and to optimize the imaging condition. Renal ASL perfusion images were acquired using signal targeting with alternated radio frequency using asymmetric inversion slab (ASTAR) technique with respiratory triggering at 3T MRI system, using either 3D True-SSFP or FFE as the readout sequence. Inversion time (TI) varied from 800 to 2400 ms...
2016: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/27865557/hypoperfusion-of-the-thalamus-is-associated-with-disability-in-relapsing-remitting-multiple-sclerosis
#13
Emilie Doche, Angèle Lecocq, Adil Maarouf, Guillaume Duhamel, Elisabeth Soulier, Sylviane Confort-Gouny, Audrey Rico, Maxime Guye, Bertrand Audoin, Jean Pelletier, Jean-Philippe Ranjeva, Wafaa Zaaraoui
BACKGROUND: While gray matter (GM) perfusion abnormalities have been evidenced in multiple sclerosis (MS) patients, the relationships with disability still remain unclear. Considering that atrophy is known to impact on perfusion, we aimed to assess perfusion abnormalities in GM of MS patients, outside atrophic regions and investigate relationships with disability. METHODS: Brain perfusion of 23 relapsing remitting MS patients and 16 matched healthy subjects were assessed at 3T using the pseudo-continuous arterial spin labeling magnetic resonance imaging technique...
November 16, 2016: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/27864008/renal-plasma-flow-rpf-measured-with-multiple-inversion-time-arterial-spin-labeling-asl-and-tracer-kinetic-analysis-validation-against-a-dynamic-contrast-enhancement-method
#14
Christopher C Conlin, Niels Oesingmann, Bradley Bolster, Yufeng Huang, Vivian S Lee, Jeff L Zhang
PURPOSE: To propose and validate a method for accurately quantifying renal plasma flow (RPF) with arterial spin labeling (ASL). MATERIALS AND METHODS: The proposed method employs a tracer-kinetic approach and derives perfusion from the slope of the ASL difference signal sampled at multiple inversion-times (TIs). To validate the method's accuracy, we performed a HIPAA-compliant and IRB-approved study with 15 subjects (9 male, 6 female; age range 24-73) to compare RPF estimates obtained from ASL to those from a more established dynamic contrast-enhanced (DCE) MRI method...
November 15, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27862767/dynamics-of-cerebral-blood-flow-in-patients-with-mild-non-ischaemic-heart-failure
#15
Christian D Erkelens, Haye H van der Wal, Bauke M de Jong, Jan-Willem Elting, Remco Renken, Marleen Gerritsen, Peter Jan van Laar, Vincent M van Deursen, Peter van der Meer, Dirk J van Veldhuisen, Adriaan A Voors, Gert-Jan Luijckx
AIMS: Heart failure (HF) is associated with tissue hypoperfusion and congestion leading to organ dysfunction. Although cerebral blood flow (CBF) is preserved over a wide range of perfusion pressures in healthy subjects, it is impaired in end-stage HF. We aimed to compare CBF, autoregulation, and cognitive function in patients with mild non-ischaemic HF with healthy controls. METHODS AND RESULTS: Fifteen patients with mild idiopathic dilated cardiomyopathy and 15 matched healthy controls were studied...
November 14, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27861605/differentiation-of-glioblastoma-from-brain-metastasis-qualitative-and-quantitative-analysis-using-arterial-spin-labeling-mr-imaging
#16
Leonard Sunwoo, Tae Jin Yun, Sung-Hye You, Roh-Eul Yoo, Koung Mi Kang, Seung Hong Choi, Ji-Hoon Kim, Chul-Ho Sohn, Sun-Won Park, Cheolkyu Jung, Chul-Kee Park
PURPOSE: To evaluate the diagnostic performance of cerebral blood flow (CBF) by using arterial spin labeling (ASL) perfusion magnetic resonance (MR) imaging to differentiate glioblastoma (GBM) from brain metastasis. MATERIALS AND METHODS: The institutional review board of our hospital approved this retrospective study. The study population consisted of 128 consecutive patients who underwent surgical resection and were diagnosed as either GBM (n = 89) or brain metastasis (n = 39)...
2016: PloS One
https://www.readbyqxmd.com/read/27859916/mild-thyrotoxicosis-leads-to-brain-perfusion-changes-an-arterial-spin-labeling-study
#17
Anna Göbel, Marcus Heldmann, Alexander Sartorius, Martin Göttlich, Anna-Luise Dirk, Georg Brabant, Thomas F Münte
Hypo- and hyperthyroidism have effects on brain structure and function as well as cognitive processes, including memory. However, little is known about the influence of thyroid hormones on brain perfusion and the relationship of such perfusion changes to cognition. This study aimed to demonstrate the effect of short-term experimental hyperthyroidism on brain perfusion in healthy volunteers and to assess whether perfusion changes, if present, are related to cognitive performance. It is known that an interaction exists between brain perfusion and cerebral oxygen consumption rate and it is believed that neural activation increases cerebral regional perfusion rate in brain areas associated with memory...
November 9, 2016: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/27858468/a-qualitative-comparison-of-arterial-spin-labelling-and-dynamic-susceptibility-contrast-mri-in-52-children-with-a-range-of-neurological-conditions
#18
Paul A Armitage, Nicholas Skipper, Daniel J A Connolly, Paul D Griffiths
OBJECTIVE: To assess the usefulness of Arterial Spin Labelling (ASL) compared with Dynamic Susceptibility Contrast (DSC) perfusion MRI for typical paediatric neuroimaging applications at 1.5 Tesla. METHODS: 52 children (age: 4 months - 17 years) with a variety of neurological disorders were scanned using 3D ASL and Echo Planar Imaging DSC sequences. All images were reviewed by an experienced neuroradiologist, image quality recorded as 'good', 'acceptable', or 'poor' and diagnostic value noted as being 'greater', 'similar' or 'less' for ASL when compared to DSC...
November 18, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27842984/usefulness-of-3-tesla-magnetic-resonance-arterial-spin-labeled-imaging-for-diagnosis-of-cranial-dural-arteriovenous-fistula
#19
Nobuaki Yamamoto, Junichiro Satomi, Yuki Yamamoto, Yuishin Izumi, Shinji Nagahiro, Ryuji Kaji
BACKGROUND AND PURPOSE: Conventional digital subtraction angiography (DSA) has been a useful tool for the diagnosis of cranial dural arteriovenous fistula (cDAVF). In most patients with cDAVF, blood flow through the arteriovenous shunt was pooled at diseased veins and/or sinuses. Therefore, we speculated that pooled blood at diseased veins in patients with cDAVF could be detected on arterial spin-labeled imaging (ASL). The purpose of the present study was to investigate the usefulness of ASL to detect cDAVF...
November 10, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27824931/glucose-metabolism-and-its-complicated-relationship-with-tumor-growth-and-perfusion-in-head-and-neck-squamous-cell-carcinoma
#20
Noriyuki Fujima, Tomohiro Sakashita, Akihiro Homma, Kenji Hirata, Tohru Shiga, Kohsuke Kudo, Hiroki Shirato
OBJECTIVE: To determine the relationship between tumor glucose metabolism and tumor blood flow (TBF) in head and neck squamous cell carcinoma (HNSCC). METHODS: We retrospectively analyzed 57 HNSCC patients. Tumor glucose metabolism was assessed by maximum and mean standardized uptake values (SUVmax and SUVmean) obtained by 18F-fluorodeoxyglucose positron-emission tomography. TBF values were obtained by arterial spin labeling with 3-tesla MRI. The correlations between both SUVs and TBF were assessed in the total series and among patients divided by T-stage (T1-T3 and T4 groups) and tumor location (pharynx/oral cavity and sinonasal cavity groups)...
2016: PloS One
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