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Arterial spin label

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https://www.readbyqxmd.com/read/29470156/journal-club-evaluation-of-diffusion-kurtosis-imaging-of-stroke-lesion-with-hemodynamic-and-metabolic-mri-in-a-rodent-model-of-acute-stroke
#1
Dongshuang Lu, Yinghua Jiang, Yang Ji, Iris Yuwen Zhou, Emiri Mandeville, Eng H Lo, Xiaoying Wang, Phillip Zhe Sun
OBJECTIVE: Diffusion kurtosis imaging (DKI) has emerged as a new acute stroke imaging approach, augmenting routine DWI. Although it has been shown that a diffusion lesion without kurtosis abnormality is more likely to recover after reperfusion, whereas a kurtosis lesion shows poor response, little is known about the underlying pathophysiologic profile of the kurtosis lesion versus the kurtosis lesion-diffusion lesion mismatch. MATERIALS AND METHODS: We performed multiparametric MRI, including arterial spin labeling, pH-sensitive amide proton transfer, and DKI, in a rodent model of acute stroke caused by embolic middle cerebral artery occlusion...
February 22, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29467681/glutamate-levels-and-resting-cerebral-blood-flow-in-anterior-cingulate-cortex-are-associated-at-rest-and-immediately-following-infusion-of-s-ketamine-in-healthy-volunteers
#2
Kirsten Borup Bojesen, Kasper Aagaard Andersen, Sophie Nordahl Rasmussen, Lone Baandrup, Line Malmer Madsen, Birte Yding Glenthøj, Egill Rostrup, Brian Villumsen Broberg
Progressive loss of brain tissue is seen in some patients with schizophrenia and might be caused by increased levels of glutamate and resting cerebral blood flow (rCBF) alterations. Animal studies suggest that the normalisation of glutamate levels decreases rCBF and prevents structural changes in hippocampus. However, the relationship between glutamate and rCBF in anterior cingulate cortex (ACC) of humans has not been studied in the absence of antipsychotics and illness chronicity. Ketamine is a noncompetitive N -methyl-D-aspartate receptor antagonist that transiently induces schizophrenia-like symptoms and neurobiological disturbances in healthy volunteers (HVs)...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29467012/structural-and-advanced-imaging-in-predicting-mgmt-promoter-methylation-of-primary-glioblastoma-a-region-of-interest-based-analysis
#3
Yu Han, Lin-Feng Yan, Xi-Bin Wang, Ying-Zhi Sun, Xin Zhang, Zhi-Cheng Liu, Hai-Yan Nan, Yu-Chuan Hu, Yang Yang, Jin Zhang, Ying Yu, Qian Sun, Qiang Tian, Bo Hu, Gang Xiao, Wen Wang, Guang-Bin Cui
BACKGROUND: The methylation status of oxygen 6-methylguanine-DNA methyltransferase (MGMT) promoter has been associated with treatment response in glioblastoma(GBM). Using pre-operative MRI techniques to predict MGMT promoter methylation status remains inconclusive. In this study, we investigated the value of features from structural and advanced imagings in predicting the methylation of MGMT promoter in primary glioblastoma patients. METHODS: Ninety-two pathologically confirmed primary glioblastoma patients underwent preoperative structural MR imagings and the efficacy of structural image features were qualitatively analyzed using Fisher's exact test...
February 21, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29464268/reversible-dilation-of-cerebral-macrovascular-changes-in-melas-episodes
#4
Yuxin Li, Weixingzi Xu, Chong Sun, Jie Lin, Jianxun Qu, Jiawen Cao, Haiqing Li, Liqin Yang
PURPOSE: To investigate the cerebral macrovascular changes as well as the relationship of large vessels and cerebral blood flow (CBF) in mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) using magnetic resonance angiography (MRA) and arterial spin labeling (ASL) perfusion MR imaging (MRI). METHODS: A total of 20 patients diagnosed with MELAS (12 males, 8 females; mean age, 23.3 years) underwent conventional MRI, time-of-flight (TOF) MRA and three dimensional ASL...
February 20, 2018: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29458384/cardiovascular-cine-imaging-and-flow-evaluation-using-fast-interrupted-steady-state-fiss-magnetic-resonance
#5
Robert R Edelman, Ali Serhal, Amit Pursnani, Jianing Pang, Ioannis Koktzoglou
BACKGROUND: Existing cine imaging techniques rely on balanced steady-state free precession (bSSFP) or spoiled gradient-echo readouts, each of which has limitations. For instance, with bSSFP, artifacts occur from rapid through-plane flow and off-resonance effects. We hypothesized that a prototype cine technique, radial fast interrupted steady-state (FISS), could overcome these limitations. The technique was compared with standard cine bSSFP for cardiac function, coronary artery conspicuity, and aortic valve morphology...
February 19, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29456122/blood-perfusion-in-left-inferior-and-middle-frontal-gyrus-predicts-communication-skills-in-schizophrenia
#6
Andrea Cantisani, Katharina Stegmayer, Andrea Federspiel, Stephan Bohlhalter, Roland Wiest, Sebastian Walther
Schizophrenia is one of the most debilitating mental disorders, severely affecting patients' community functioning. Functional capacity (FC) describes the skills necessary for successful functional outcome (FO), such as financial knowledge or communication skills. We investigated whether resting-state cerebral blood flow (rCBF) measured at baseline with arterial spin labeling (ASL) would predict FC or FO at a 6-months follow-up in 27 schizophrenia patients. A negative linear association was noted between FC and rCBF in the left inferior and middle frontal gyrus, areas involved in language processing, suggesting a potential relationship between cerebral perfusion and prospective FC in schizophrenia...
February 10, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29454933/effects-of-resting-state-condition-on-reliability-trait-specificity-and-network-connectivity-of-brain-function-measured-with-arterial-spin-labeled-perfusion-mri
#7
Zhengjun Li, Marta Vidorreta, Natalie Katchmar, David C Alsop, Daniel H Wolf, John A Detre
Resting state fMRI (rs-fMRI) provides imaging biomarkers of task-independent brain function that can be associated with clinical variables or modulated by interventions such as behavioral training or pharmacological manipulations. These biomarkers include time-averaged regional brain function as manifested by regional cerebral blood flow (CBF) measured using arterial spin labeled (ASL) perfusion MRI and correlated temporal fluctuations of function across brain networks with either ASL or blood oxygenation level dependent (BOLD) fMRI...
February 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/29453753/pediatric-astrocytic-tumor-grading-comparison-between-arterial-spin-labeling-and-dynamic-susceptibility-contrast-mri-perfusion
#8
Giovanni Morana, Domenico Tortora, Serena Staglianò, Paolo Nozza, Samantha Mascelli, Mariasavina Severino, Gianluca Piatelli, Alessandro Consales, Maarten Lequin, Maria Luisa Garrè, Andrea Rossi
PURPOSE: The aim of this study was to compare arterial spin labeling (ASL) and dynamic susceptibility contrast (DSC) MRI perfusion with respect to diagnostic performance in tumor grading in pediatric patients with low- and high-grade astrocytic tumors (AT). METHODS: We retrospectively analyzed 37 children with histologically proven treatment naive low- and high-grade AT who underwent concomitant pre-operative ASL and DSC MRI perfusion. Studies were performed on a 1...
February 16, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29452984/quantitative-cerebrovascular-pathology-in-a-community-based-cohort-of-older-adults
#9
Swati Rane, Natalie Koh, Peter Boord, Tara Madhyastha, Mary K Askren, Suman Jayadev, Brenna Cholerton, Eric Larson, Thomas J Grabowski
Cerebrovascular disease, especially small vessel pathology, is the leading comorbidity in degenerative disorders. We applied arterial spin labeling and cerebrovascular reserve (CVR) imaging to quantify small vessel disease and study its effect on cognitive symptoms in nondemented older adults from a community-based cohort. We evaluated baseline cerebral blood flow (CBF) using arterial spin labeling and percent signal change as a marker of CVR using blood-oxygen level-dependent imaging following a breath-hold stimulus...
January 31, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29450932/cardiorespiratory-noise-correction-improves-the-asl-signal
#10
Mahlega S Hassanpour, Qingfei Luo, W Kyle Simmons, Justin S Feinstein, Martin P Paulus, Wen-Ming Luh, Jerzy Bodurka, Sahib S Khalsa
Cardiorespiratory fluctuations such as changes in heart rate or respiration volume influence the temporal dynamics of cerebral blood flow (CBF) measurements during arterial spin labeling (ASL) fMRI. This "physiological noise" can confound estimates of resting state network activity, and it may lower the signal-to-noise ratio of ASL during task-related experiments. In this study we examined several methods for minimizing the contributions of both synchronized and non-synchronized physiological noise in ASL measures of CBF, by combining the RETROICOR approach with different linear deconvolution models...
February 15, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29447849/three-dimensional-arterial-spin-labeling-imaging-with-a-dante-preparation-pulse
#11
Tsuyoshi Matsuda, Hirohiko Kimura, Hiroyuki Kabasawa, Masayuki Kanamoto
On arterial spin-labeled (ASL) images, areas of bright intravascular signal will appear when the post labeling delay time is shorter than arterial transit time. Vascular suppression (VS) schemes reduce artefactual bright signal by dephasing intravascular labeled spins. However, existing VS methods, such as Motion-Sensitized Driven-Equilibrium (MSDE), decrease the uniformity of the signal intensity distribution and extend the echo time. The purpose of this study is to compare VS using a Delays Alternating with Nutation for Tailored Excitation (DANTE) preparation pulse, with MSDE for ASL imaging on a flow phantom and volunteer data...
February 12, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29440719/prefrontal-gaba-levels-hippocampal-resting-perfusion-and-the-risk-of-psychosis
#12
Gemma Modinos, Fatma Şimşek, Matilda Azis, Matthijs Bossong, Ilaria Bonoldi, Carly Samson, Beverly Quinn, Jesus Perez, Matthew R Broome, Fernando Zelaya, David J Lythgoe, Oliver D Howes, James M Stone, Anthony A Grace, Paul Allen, Philip McGuire
Preclinical models propose that the onset of psychosis is associated with hippocampal hyperactivity, thought to be driven by cortical GABAergic interneuron dysfunction and disinhibition of pyramidal neurons. Recent neuroimaging studies suggest that resting hippocampal perfusion is increased in subjects at ultra-high risk (UHR) for psychosis, but how this may be related to GABA concentrations is unknown. The present study used a multimodal neuroimaging approach to address this issue in UHR subjects. Proton magnetic resonance spectroscopy and pulsed-continuous arterial spin labeling imaging were acquired to investigate the relationship between medial prefrontal (MPFC) GABA+ levels (including some contribution from macromolecules) and hippocampal regional cerebral blood flow (rCBF) in 36 individuals at UHR of psychosis, based on preclinical evidence that MPFC dysfunction is involved in hippocampal hyperactivity...
January 30, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29436733/placental-perfusion-imaging-using-velocity-selective-arterial-spin-labeling
#13
Zungho Zun, Catherine Limperopoulos
PURPOSE: The placenta remains the least understood human organ, in large part because of the lack of noninvasive tools currently available to examine placental function in vivo. This study investigates the feasibility of using velocity-selective arterial spin labeling (VSASL) to assess placental perfusion. METHODS: In placental perfusion imaging, VSASL was compared with pseudocontinuous ASL (PCASL), which is currently the standard technique in brain arterial spin labeling (ASL)...
February 13, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29434092/water-diffusion-in-the-brain-of-chronic-hypoperfusion-model-mice-a-study-considering-the-effect-of-blood-flow
#14
Takuya Urushihata, Hiroyuki Takuwa, Chie Seki, Yasuhiko Tachibana, Manami Takahashi, Jeff Kershaw, Yuhei Takado, Ichio Aoki, Makoto Higuchi, Hiroshi Ito, Takayuki Obata
PURPOSE: Chronic cerebral hypoperfusion model mice were created by unilateral common carotid artery occlusion (UCCAO) surgery, which does not cause cerebral infarction, but which does cause long-term reduction in cerebral blood flow (CBF) to the occluded side. Cognitive dysfunction in this mouse model has been demonstrated in behavioral experiments, but neuron density change was not found in a previous positron emission tomography (PET) study. As a next step, in this study we investigated the injury of neuronal fibers in chronic cerebral hypoperfusion model mice using diffusion tensor imaging (DTI)...
February 13, 2018: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29431005/reduced-blood-oxygenation-level-dependent-connectivity-is-related-to-hypoperfusion-in-alzheimer-s-disease
#15
Jens Göttler, Christine Preibisch, Isabelle Riederer, Lorenzo Pasquini, Panagiotis Alexopoulos, Karl Peter Bohn, Igor Yakushev, Ebba Beller, Stephan Kaczmarz, Claus Zimmer, Timo Grimmer, Alexander Drzezga, Christian Sorg
Functional connectivity of blood oxygenation level dependent signal fluctuations (BOLD-FC) is decreased in Alzheimer's disease (AD), and suggested to reflect reduced coherence in neural population activity; however, as both neuronal and vascular-hemodynamic processes underlie BOLD signals, impaired perfusion might also contribute to reduced BOLD-FC; 42 AD patients and 27 controls underwent simultaneous PET/MR imaging. Resting-state functional MRI assessed BOLD co-activity to quantify BOLD-FC, pulsed arterial spin labeling (pASL) assessed cerebral blood flow (CBF) as proxy for vascular hemodynamics, and 18F-fluorodeoxyglucose PET assessed glucose metabolism (GluMet) to index neuronal activity...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29427325/controlling-t2-blurring-in-3d-rare-arterial-spin-labeling-acquisition-through-optimal-combination-of-variable-flip-angles-and-k-space-filtering
#16
Li Zhao, Ching-Di Chang, David C Alsop
PURPOSE: To improve the SNR efficiency and reduce the T2 blurring of 3D rapid acquisition with relaxation enhancement stack-of-spiral arterial spin labeling imaging by using variable refocusing flip angles and k-space filtering. METHODS: An algorithm for determining the optimal combination of variable flip angles and filtering correction is proposed. The flip angles are designed using extended phase graph physical simulations in an analytical and global optimization framework, with an optional constraint on deposited power...
February 9, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29422857/application-of-arterial-spin-labelling-in-detecting-retinal-ischemia
#17
Ehsan Vaghefi, Kevin Kauv, Wilson Pan, David Squirrell
Purpose: Here, we have tried to quantify the chorioretinal blood perfusion in patients who are clinically identified to be suffering from retinal ischemia using arterial spin labelling (ASL) MRI. Method: Four participants, diagnosed with retinal ischemia based on their structural OCT and angiography test, were then scanned using anatomical MRI as well as ASL. We optimized MR parameters to maximize resolution and target fixation, blinking, and breathing ques to minimize motion artifacts...
September 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29416525/patient-specific-alterations-in-co2-cerebrovascular-responsiveness-in-acute-and-sub-acute-sports-related-concussion
#18
W Alan C Mutch, Michael J Ellis, Lawrence N Ryner, Patrick J McDonald, Marc P Morissette, Philip Pries, Marco Essig, David J Mikulis, James Duffin, Joseph A Fisher
Background: Preliminary studies suggest that sports-related concussion (SRC) is associated with alterations in cerebral blood flow (CBF) regulation. Here, we use advanced magnetic resonance imaging (MRI) techniques to measure CBF and cerebrovascular responsiveness (CVR) in individual SRC patients and healthy control subjects. Methods: 15 SRC patients (mean age = 16.3, range 14-20 years) and 27 healthy control subjects (mean age = 17.6, range 13-21 years) underwent anatomical MRI, pseudo-continuous arterial spin labeling (pCASL) MRI and model-based prospective end-tidal targeting (MPET) of CO2 during blood oxygenation level-dependent (BOLD) MRI...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29398151/differentiation-between-radiation-induced-brain-injury-and-glioma-recurrence-using-3d-pcasl-and-dynamic-susceptibility-contrast-enhanced-perfusion-weighted-imaging
#19
Yu-Lin Wang, Si Chen, Hua-Feng Xiao, Ying Li, Yan Wang, Gang Liu, Xin Lou, Lin Ma
PURPOSE: This study was performed to validate the efficacy of three-dimensional pseudocontinuous arterial spin labeling (pCASL) compared with dynamic susceptibility contrast-enhanced perfusion-weighted imaging (DSC-PWI) in distinguishing radiation-induced brain injury from glioma recurrence in patients with glioma. METHODS: Both 3D pCASL and DSC-PWI were performed using a 3.0 Tesla scanner in 69 patients with previously resected and irradiated glioma who displayed newly developed abnormal contrast-enhanced lesions...
February 1, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29391824/altered-perfusion-of-the-sensorimotor-cortex-in-patients-with-cervical-spondylotic-myelopathy-an-arterial-spin-labeling-study
#20
Fuqing Zhou, Muhua Huang, Lin Wu, Yongming Tan, Jianqiang Guo, Yong Zhang, Laichang He, Honghan Gong
Objective: Advanced magnetic resonance imaging studies have shown functional plasticity or reorganization and metabolite alterations of N-acetyl aspartate in the sensorimotor cortex (SMC), a hallmark region and key brain network, in patients with cervical spondylotic myelopathy (CSM). However, the nature of perfusion in the SMC and the relationship between regional cerebral blood flow (CBF), motor function scores, and structural damage of the cervical cord in patients with CSM are not fully understood...
2018: Journal of Pain Research
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