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https://www.readbyqxmd.com/read/28922888/end-to-side-and-end-to-end-double-in-situ-bypass-with-submilimeter-m4-branches-for-treatment-of-ruptured-mycotic-aneurysm-3-dimensional-operative-video
#1
Yahya Turan, Ulas Cikla, Abdulbaki Kozan, Mustafa K Baskaya
No abstract text is available yet for this article.
October 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28922877/use-of-a-polytetrafluoroethylene-coated-vascular-plug-for-focal-intracranial-parent-vessel-sacrifice-for-fusiform-aneurysm-treatment
#2
Andrew P Carlson, Mohammad Abbas, Patricia Hall, Christopher Taylor
BACKGROUND: Fusiform intracranial aneurysms are challenging due to the circumferential nature of the disease. Endovascular parent vessel sacrifice with coils may be a treatment option, but typically requires a long vessel segment to induce complete cessation of flow. OBJECTIVE:   We evaluate early clinical experience with the intracranial use of the microvascular plug (MVP; Medtronic, Dublin, Ireland) device and to compare to previous coil-only techniques for vertebral artery sacrifice for fusiform vertebral aneurysm...
October 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28922829/the-threshold-of-the-state-civil-defence-the-blackout-and-the-home-in-second-world-war-britain
#3
James Greenhalgh
This article reconsiders the way that the British state extended its control of the home during the Second World War, using the implementation of air raid precautions and the blackout as a lens through which to view the state's developing attitudes to domestic space. Presented here is not the familiar story of pitch-dark, dangerous streets or altered cityscapes of fear and destruction; instead, by examining personal testimony the article inverts traditional treatments of the blackout to look at the interior of dwellings, demonstrating how the realities of total warfare impinged upon the psychological elements that constituted the home...
June 1, 2017: 20 Century British History
https://www.readbyqxmd.com/read/28922787/optimal-duration-of-extended-adjuvant-endocrine-therapy-for-early-breast-cancer-results-of-the-ideal-trial-boog-2006-05
#4
Erik J Blok, Judith R Kroep, Elma Meershoek-Klein Kranenbarg, Marjolijn Duijm-de Carpentier, Hein Putter, Joan van den Bosch, Eduard Maartense, A Elise van Leeuwen-Stok, Gerrit-Jan Liefers, Johan W R Nortier, Emiel J Th Rutgers, Cornelis J H van de Velde
Background: The optimal duration of extended endocrine therapy beyond five years after initial aromatase inhibitor-based adjuvant therapy for postmenopausal women with hormone receptor-positive breast cancer is still unknown. Therefore, we conducted a clinical trial to compare two different extended endocrine therapy durations. Methods: In the randomized phase III IDEAL trial, postmenopausal patients with hormone receptor-positive breast cancer were randomly allocated to either 2...
January 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28922786/relapse-free-survival-as-a-surrogate-for-overall-survival-in-the-evaluation-of-stage-ii-iii-melanoma-adjuvant-therapy
#5
Stefan Suciu, Alexander M M Eggermont, Paul Lorigan, John M Kirkwood, Svetomir N Markovic, Claus Garbe, David Cameron, Srividya Kotapati, Tai-Tsang Chen, Keith Wheatley, Natalie Ives, Gaetan de Schaetzen, Achmad Efendi, Marc Buyse
Background: We assessed whether relapse-free survival (RFS; time until recurrence/death) is a valid surrogate for overall survival (OS) among resected stage II-III melanoma patients through a meta-analysis of randomized controlled trials. Methods: Individual patient data (IPD) on RFS and OS were collected from 5826 patients enrolled in 11 randomized adjuvant trials comparing interferon (IFN) to observation. In addition, IPD from two studies comparing IFN and vaccination in 989 patients were included...
January 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28922727/the-relevance-of-gastric-cancer-biomarkers-in-prognosis-and-pre-and-post-chemotherapy-in-clinical-practice
#6
REVIEW
Muhammad Abbas, Murad Habib, Muhammad Naveed, Kumaragurubaran Karthik, Kuldeep Dhama, Meiqi Shi, Chen Dingding
Gastric cancer (GC) is one among the major cancer types, causing human deaths and present noticeable heterogeneity. The incidences and mortality rates are higher in males in comparison to females with a male to female ratio of 2.3:1. A lot of studies have revealed out the molecular basis, pathogenesis, invasion and metastasis related findings of gastric stomach cancer. Present review encompasses the salient information on various biomarkers for the early diagnosis, treatment and prognosis of gastric cancer elaborate the clinical importance of serum tumor markers in patients with this cancer as well as checking the growths, together with epigenetic changes and genetic polymorphisms...
September 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28922718/tanshinone-iia-protects-against-chronic-intermittent-hypoxia-induced-myocardial-injury-via-activating-the-endothelin-1-pathway
#7
Na Wang, Yue Chang, Lingling Chen, Ya-Jing Guo, Ya-Shuo Zhao, Qiu-Hong Guo, En-Sheng Ji
Tanshinone IIA (Tan IIA) may exert significant protective effects against heart oxidative stress damage in obstructive sleep apnoea (OSA) syndrome. Chronic intermittent hypoxia (CIH)-triggered left ventricular dysfunction is used in a rat model to mimic CIH in OSA patients. 48 rats were randomly divided into three groups: normal control (NC) group, CIH group and CIH+Tan IIA group with 16 rats in each group. At the end of experiment (day 21), the blood pressure, Plasma ET-1 and NO content, hemodynamic indexes, heart histology, myocardial apoptosis as well as the expression of eNOS, ET-1, ETA receptor and ETB receptor were compared among different groups...
September 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28922706/functional-outcome-of-low-rectal-resection-evaluated-by-anorectal-manometry
#8
Peter Ihnát, Petr Vávra, Jiří Prokop, Anton Pelikán, Lucia Ihnát Rudinská, Igor Penka
BACKGROUND: Low anterior resection syndrome (LARS) covers disordered bowel function after rectal resection, leading to deterioration in patients' quality of life. The aim of this study was to evaluate anorectal function after laparoscopic low anterior resection (LAR) by means of standardized instruments. METHODS: This was a prospective clinical cohort study conducted in a single institution to assess functional outcome of patients 1 year after laparoscopic LAR by means of LARS score and high-resolution anorectal manometry...
September 18, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28922625/living-and-dying-with-advanced-dementia-a-prospective-cohort-study-of-symptoms-service-use-and-care-at-the-end-of-life
#9
Elizabeth L Sampson, Bridget Candy, Sarah Davis, Anna Buylova Gola, Jane Harrington, Michael King, Nuriye Kupeli, Gerry Leavey, Kirsten Moore, Irwin Nazareth, Rumana Z Omar, Victoria Vickerstaff, Louise Jones
BACKGROUND: Increasing number of people are dying with advanced dementia. Comfort and quality of life are key goals of care. AIMS: To describe (1) physical and psychological symptoms, (2) health and social care service utilisation and (3) care at end of life in people with advanced dementia. DESIGN: 9-month prospective cohort study. SETTING AND PARTICIPANTS: Greater London, England, people with advanced dementia (Functional Assessment Staging Scale 6e and above) from 14 nursing homes or their own homes...
August 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28922557/disease-prevalence-dependent-failure-rate-in-diagnostic-management-studies-on-suspected-deep-vein-thrombosis-communication-from-the-ssc-of-the-isth
#10
C E A Dronkers, Y M Ende-Verhaar, P A Kyrle, M Righini, S C Cannegieter, M V Huisman, F A Klok
No abstract text is available yet for this article.
August 20, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28922523/mature-b-cells-accelerate-wound-healing-after-acute-and-chronic-diabetic-skin-lesions
#11
Ruxandra F Sîrbulescu, Chloe K Boehm, Erin Soon, Moses Q Wilks, Iulian Ilieş, Hushan Yuan, Ben Maxner, Nicolas Chronos, Charalambos Kaittanis, Marc D Normandin, Georges El Fakhri, Dennis P Orgill, Ann E Sluder, Mark C Poznansky
Chronic wounds affect 12-15% of patients with diabetes and are associated with a drastic decrease in their quality of life. Here we demonstrate that purified mature naïve B220(+) /CD19(+) /IgM(+) /IgD(+) B cells improve healing of acute and diabetic murine wounds after a single topical application. B cell treatment significantly accelerated acute wound closure by 2-3 days in wild-type mice and 5-6 days in obese diabetic mice. The treatment led to full closure in 43% of chronic diabetic wounds, as compared to only 5% in saline-treated controls...
September 18, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28922519/a-cost-minimisation-analysis-of-olive-oil-versus-hyperoxygenated-fatty-acid-treatment-for-the-prevention-of-pressure-ulcers-in-primary-health-care-a-randomised-controlled-trial
#12
Inmaculada Lupiañez-Pérez, Juan Carlos Morilla-Herrera, Shakira Kaknani-Uttumchanchandani, Yolanda Lupiañez-Perez, Magdalena Cuevas-Fernandez-Gallego, Francisco Martin-Santos, Jorge Caro-Bautista, Jose Miguel Morales-Asencio
Pressure ulcers represent a major current health problem and cause an important economic impact on the health care system. Most studies on the prevention of pressure ulcers have been carried out in hospital contexts, with respect to the use of hyperoxygenated fatty acids, and to date no studies have specifically examined the use of olive oil-based treatments. AIM: To evaluate the cost of using extra virgin olive oil, rather than hyperoxygenated fatty acids, in the prevention of pressure ulcers among persons with impaired mobility and receiving home care...
September 18, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28922496/intramolecular-sear-of-phosphorus-derivatives-computational-approach-to-the-synthesis-of-%C3%AF-extended-heterocycles
#13
Olatz Larrañaga, Carlos Romero-Nieto, Abel de Cozar Ruano
The reaction mechanism associated with the synthesis of phosphorus-based heteropolyaromatic architectures by intramolecular SEAr have been investigated by DFT calculations at the B3LYP-D3/6-311+G(D) level of theory. The purpose of this study is to provide essential information for the future development of improved polycyclic organophosphorus materials. To that end, we have studied the impact of the initial reactant and/or the intermediates' structure into the mechanistic features and energetic profiles of the phosphorus cyclization process...
September 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28922440/real-life-use-of-3-direct-acting-antiviral-regimen-in-a-large-cohort-of-patients-with-genotype-1b-hcv-compensated-cirrhosis
#14
Liana Gheorghe, Speranta Iacob, Manuela Curescu, Ciprian Brisc, Cristina Cijevschi, Florin Caruntu, Carol Stanciu, Iulia Simionov, Ioan Sporea, Cristian Gheorghe, Razvan Iacob, Victoria Arama, Roxana Sirli, Anca Trifan
BACKGROUND AND AIMS: Ombitasvir/Paritaprevir/ritonavir/Dasabuvir (OBV/PTV/r+DSV) is one of the elective direct-acting antivirals (DAAs) recommended by international guidelines and the only one covered by the National Insurance System in Romania until November 2016. Our aim was to present the first prospective Romanian cohort evaluating the effectiveness and safety in clinical practice of this 3DAA combination in patients with HCV genotype-1b Child A liver cirrhosis. METHODS: 681 patients received OBV/PTV/r+DSV+RBV for 12 weeks and were assessed clinically and biologically at baseline, week 4, 8, 12 (end of treatment, EOT), and 12 weeks after therapy (sustained viral response, SVR)...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28922436/genetic-risk-factors-for-autoimmune-thyroid-disease-might-affect-the-susceptibility-to-and-modulate-the-progression-of-primary-biliary-cholangitis
#15
Aleksander Kuś, Magdalena Arłukowicz-Grabowska, Konrad Szymański, Ewa Wunsch, Małgorzata Milkiewicz, Rafał Płoski, Zakera Shums, Gary L Norman, Piotr Milkiewicz, Tomasz Bednarczuk, Marcin Krawczyk
BACKGROUND AND AIMS: Patients with primary biliary cholangitis (PBC) frequently suffer from extrahepatic autoimmune conditions, of which autoimmune thyroid disease (AITD) is one of the most common. Previous studies identified several genetic variants increasing the odds of developing AITD. Here we investigate whether AITD-associated polymorphisms might also play a role in the development and clinical course of PBC and PBC associated with AITD (PBC-AITD). METHODS: To this end, we prospectively recruited 230 patients with PBC and 421 healthy controls...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28922435/effectiveness-and-safety-of-golimumab-in-treating-outpatient-ulcerative-colitis-a-real-life-prospective-multicentre-observational-study-in-primary-inflammatory-bowel-diseases-centers
#16
Antonio Tursi, Leonardo Allegretta, Nello Buccianti, Nicola Della Valle, Walter Elisei, Giacomo Forti, Roberto Faggiani, Sara Gallina, Yusef Hadad, Tiziana Larussa, Angelo Lauria, Francesco Luzza, Roberto Lorenzetti, Giammarco Mocci, Antonio Penna, Natale Polimeni, Giuseppe Pranzo, Cristina Ricciardelli, Costantino Zampaletta, Marcello Picchio
BACKGROUND AND AIMS: Golimumab (GOL) has been recently approved in Italy for the treatment of ulcerative colitis (UC) unresponsive to standard treatments. Our aims were to assess the real-life efficacy and safety of GOL in managing UC outpatients in Italian primary Inflammatory Bowel Diseases (IBD) centres. METHODS: Consecutive UC outpatients with at least 3-months follow-up were enrolled. Primary end-point was the induction and maintenance of remission in UC, defined as Mayo score </=2, at 6-month follow-up...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28922433/bismuth-based-quadruple-therapy-following-h-pylori-eradication-failures-a-multicenter-study-in-clinical-practice
#17
Angelo Zullo, Vincenzo De Francesco, Annamaria Bellesia, Roberto Vassallo, Audenzio D'Angelo, Giuseppe Scaccianoce, Rodolfo Sacco, Giampaolo Bresci, Annarita Eramo, Anna Tanzilli, Lorenzo Ridola, Domenico Alvaro, Claudio Londoni, Gianfranco Brambilla, Raffaele Manta, Agostino Di Ciaula, Piero Portincasa
BACKGROUND AND AIMS: Helicobacter pylori (H. pylori) eradication in patients who failed one or more therapeutic attempts remains challenging. This study aimed to assess the efficacy of three-in-one capsules bismuth-based quadruple therapy (Pylera®) in these patients managed in clinical practice. METHODS: This was a prospective, open-label, multicenter study enrolling consecutive, adult patients with persistent H. pylori infection following at least one standard therapy...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28922391/impedance-biosensor-for-real-time-monitoring-and-prediction-of-thrombotic-individual-profile-in-flowing-blood
#18
Denise De Zanet, Monica Battiston, Elisabetta Lombardi, Ruben Specogna, Francesco Trevisan, Luigi De Marco, Antonio Affanni, Mario Mazzucato
A new biosensor for the real-time analysis of thrombus formation is reported. The fast and accurate monitoring of the individual thrombotic risk represents a challenge in cardiovascular diagnostics and in treatment of hemostatic diseases. Thrombus volume, as representative index of the related thrombotic status, is usually estimated with confocal microscope at the end of each in vitro experiment, without providing a useful behavioral information of the biological sample such as platelets adhesion and aggregation in flowing blood...
2017: PloS One
https://www.readbyqxmd.com/read/28922362/early-relapses-after-adjuvant-chemotherapy-suggests-primary-chemoresistance-in-diffuse-gastric-cancer
#19
Sharon Pattison, Catherine Mitchell, Stephen Lade, Trevor Leong, Rita A Busuttil, Alex Boussioutas
BACKGROUND: Survival from gastric cancer remains poor, particularly in Western populations. Previous pre-clinical and subgroup analyses of clinical trials have suggested differing benefits from fluoropyrimidine-based chemotherapeutics for diffuse and intestinal gastric cancer. This analysis examines patterns of relapse with and without adjuvant chemotherapy after curative resection for gastric cancer in these subtypes to explore the Lauren classification as a predictive marker of benefit for fluoropyrimidine-based adjuvant chemotherapy...
2017: PloS One
https://www.readbyqxmd.com/read/28922295/spiritual-needs-of-patients-with-cancer-in-palliative-care-an-integrative-review
#20
Ana Cláudia Mesquita, Érika de Cássia Lopes Chaves, Guilherme Antônio Moreira de Barros
PURPOSE OF REVIEW: The experience of a life crisis, such as the experience of end-of-life terminality whenever facing cancer can make the spiritual needs of patients clear. The goal of this revision was to synthesize the existing evidence regarding the spiritual needs of patients with cancer in palliative care. RECENT FINDINGS: An integrated revision of the literature was conducted regarding the database sources from PubMed, CINAHL, EMBASE, LILACS and Scopus, without publishing year restrictions...
September 15, 2017: Current Opinion in Supportive and Palliative Care
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