keyword
https://read.qxmd.com/read/38517847/development-and-validation-of-multiplex-one-step-qpcr-rt-qpcr-assays-for-simultaneous-detection-of-sars-cov-2-and-pathogens-associated-with-feline-respiratory-disease-complex
#1
JOURNAL ARTICLE
Côme J Thieulent, Mariano Carossino, Laura Peak, Wendy Wolfson, Udeni B R Balasuriya
Feline respiratory disease complex (FRDC) is caused by a wide range of viral and bacterial pathogens. Both Influenza A virus (IAV) and Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) also induce respiratory diseases in cats. Two one-step multiplex qPCR/RT-qPCR assays were developed and validated: FRA_1 (Feline respiratory assay 1) for the detection of four viral targets and FRA_2 for the detection of three bacteria associated with FRDC. Both multiplex assays demonstrated high specificity, efficiency (93...
2024: PloS One
https://read.qxmd.com/read/38231728/antibacterial-and-antiviral-properties-of-pinus-densiflora-essential-oil
#2
JOURNAL ARTICLE
Yu Jin Oh, Yeong-Su Kim, Jae Woo Kim, Dae Wook Kim
The Korean mountains are home to the Korean red pine ( Pinus densiflora ). Pine needle oil has been used as a food additive and a traditional herbal medicine; however, any health-related properties of its trunk oil remain unknown. Herein, we assessed antibacterial and antiviral properties of essential oil extracted from the trunk of P. densiflora . Th extracted oil was hydrodistilled using a Clevenger apparatus and analyzed using gas chromatography-mass spectrometry. The antimicrobial activity of the oil was tested using the microbroth dilution technique against 10 bacterial species (6 g-positive and 4 g-negative) and fungi...
November 27, 2023: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38212868/ph-dependent-virucidal-effects-of-weak-acids-against-pathogenic-viruses
#3
JOURNAL ARTICLE
Weiyin Hu, Hiroshi Shimoda, Yoshihiro Tsuchiya, Mikiya Kishi, Daisuke Hayasaka
BACKGROUND: Weak acids, such as acetic acid, show virucidal effects against viruses, and disinfectants are considered effective virucidal agents possibly because of their low pH, depending on the proton concentration. This study aimed to evaluate the efficacy of different weak acids (acetic, oxalic, and citric acids) and eligible vinegars under different pH conditions by comparing their inactivation efficacies against enveloped and non-enveloped viruses. METHODS: Acetic, oxalic, and citric acids were adjusted to pH values of 2, 4 and 6, respectively...
January 12, 2024: Tropical Medicine and Health
https://read.qxmd.com/read/38143863/concern-regarding-h3-subtype-avian-influenza-virus
#4
REVIEW
Jiantao Yu, Qiucheng Yao, Jing Liu, Yan Zhou, Miaotong Huo, Ye Ge
The H3-subtype of avian influenza virus (AIV) is one of the most frequently detected low pathogenic avian influenza virus (LPAIV) subtypes in birds and fowls, causing substantial economic loss to the poultry industry. Most importantly, besides poultry, mammals could also be infected with it, such as swines, canines, equines, felines, and humans, posing a serious public health threat. This allows the virus to persist widely in poultry and wild birds for a long time, where it may mix with other subtypes, providing conditions for viral recombination or reassortment...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38003488/kaempferol-a-review-of-current-evidence-of-its-antiviral-potential
#5
REVIEW
Argyrios Periferakis, Aristodemos-Theodoros Periferakis, Lamprini Troumpata, Konstantinos Periferakis, Andreea-Elena Scheau, Ilinca Savulescu-Fiedler, Ana Caruntu, Ioana Anca Badarau, Constantin Caruntu, Cristian Scheau
Kaempferol and its derivatives are flavonoids found in various plants, and a considerable number of these have been used in various medical applications worldwide. Kaempferol and its compounds have well-known antioxidant, anti-inflammatory and antimicrobial properties among other health benefits. However, the antiviral properties of kaempferol are notable, and there is a significant number of experimental studies on this topic. Kaempferol compounds were effective against DNA viruses such as hepatitis B virus, viruses of the alphaherpesvirinae family, African swine fever virus, and pseudorabies virus; they were also effective against RNA viruses, namely feline SARS coronavirus, dengue fever virus, Japanese encephalitis virus, influenza virus, enterovirus 71, poliovirus, respiratory syncytial virus, human immunodeficiency virus, calicivirus, and chikungunya virus...
November 14, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37935596/assessing-vaccine-hesitancy-and-support-for-vaccination-requirements-for-pets-and-potential-spillovers-from-humans
#6
JOURNAL ARTICLE
Simon F Haeder
BACKGROUND: Growing vaccination hesitancy is well-document among humans. However, we know very little about vaccination hesitancy for pets as well as whether the two phenomena are interconnected. Moreover, support for pet vaccination requirements also remain underassessed. METHODS: We fielded a large, national survey (N = 3,958) on August 18 and August 19, 2023, to assess U.S. public opinion about the vaccination status of dogs (rabies, canine parvovirus, canine distemper, canine influenza, and Lyme disease) and cats (rabies, feline panleukopenia (parvo), feline herpesvirus-1, feline chlamydia, and feline Bordetella) in the United States...
November 5, 2023: Vaccine
https://read.qxmd.com/read/37823646/4-octyl-itaconate-reduces-influenza-a-replication-by-targeting-the-nuclear-export-protein-crm1
#7
JOURNAL ARTICLE
Pau Ribó-Molina, Hauke J Weiss, Balasubramanian Susma, Stefan van Nieuwkoop, Leentje Persoons, Yunan Zheng, Melanie Ruzek, Dirk Daelemans, Ron A M Fouchier, Luke A J O'Neill, Bernadette G van den Hoogen
In recent years, especially since the outbreak of the severe acute respiratory syndrome coronavirus 2 pandemic, the cell-permeable itaconate derivative 4-octyl itaconate (4-OI) has gained traction as a potential antiviral agent. Here, we demonstrate that 4-OI inhibits replication of multiple influenza A viruses (IAV) by restricting nuclear export of viral ribonucleoproteins, a key step in the IAV replication cycle. This nuclear retention is achieved by deactivation and subsequent degradation of chromosomal maintenance 1 protein (CRM1), also known as exportin 1 (XPO1), a host cell protein exploited by IAV during replication...
October 12, 2023: Journal of Virology
https://read.qxmd.com/read/37713971/methods-for-virus-recovery-from-environmental-surfaces-to-monitor-infectious-viral-contamination
#8
JOURNAL ARTICLE
Hajime Miyazaki, Ryohei Hirose, Mikako Ichikawa, Hiroki Mukai, Katsuma Yamauchi, Takaaki Nakaya, Yoshito Itoh
Accurate quantification of infectious contaminants on environmental surfaces, particularly infectious viruses, is essential for contact transmission risk assessment; however, difficulties in recovering viruses from surfaces using swabs complicates this quantification process. Herein, we identified the factors that significantly affected virus recovery rates and developed an ideal swab method that yielded the highest rate of virus recovery. We comprehensively analyzed the effects of swab type (cotton/polyester), swab water content (wet/dry conditions), surface material, and surface area on the rates of viral RNA and infectious virus recovery...
September 9, 2023: Environment International
https://read.qxmd.com/read/37684136/the-neuropathogenesis-of-highly-pathogenic-avian-influenza-h5nx-viruses-in-mammalian-species-including-humans
#9
REVIEW
Lisa Bauer, Feline F W Benavides, Edwin J B Veldhuis Kroeze, Emmie de Wit, Debby van Riel
Circulation of highly pathogenic avian influenza (HPAI) H5Nx viruses of the A/Goose/Guangdong/1/96 lineage in birds regularly causes infections of mammals, including humans. In many mammalian species, infections are associated with severe neurological disease, a unique feature of HPAI H5Nx viruses compared with other influenza A viruses. Here, we provide an overview of the neuropathogenesis of HPAI H5Nx virus infection in mammals, centered on three aspects: neuroinvasion, neurotropism, and neurovirulence. We focus on in vitro studies, as well as studies on naturally or experimentally infected mammals...
September 6, 2023: Trends in Neurosciences
https://read.qxmd.com/read/37485254/avian-influenza-overview-april-june-2023
#10
JOURNAL ARTICLE
Cornelia Adlhoch, Alice Fusaro, José L Gonzales, Thijs Kuiken, Angeliki Melidou, Gražina Mirinavičiūtė, Éric Niqueux, Karl Ståhl, Christoph Staubach, Calogero Terregino, Francesca Baldinelli, Alessandro Broglia, Lisa Kohnle
Between 29 April and 23 June 2023, highly pathogenic avian influenza (HPAI) A(H5N1) virus (clade 2.3.4.4b) outbreaks were reported in domestic (98) and wild (634) birds across 25 countries in Europe. A cluster of outbreaks in mulard ducks for foie gras production was concentrated in Southwest France, whereas the overall A(H5N1) situation in poultry in Europe and worldwide has eased. In wild birds, black-headed gulls and several new seabird species, mostly gulls and terns (e.g. sandwich terns), were heavily affected, with increased mortality being observed in both adults and juveniles after hatching...
July 2023: EFSA journal
https://read.qxmd.com/read/37184410/rapid-virucidal-activity-of-japanese-saxifraga-species-derived-condensed-tannins-against-sars-cov-2-influenza-a-virus-and-human-norovirus-surrogate-viruses
#11
JOURNAL ARTICLE
Toshihiro Murata, Dulamjav Jamsransuren, Sachiko Matsuda, Haruko Ogawa, Yohei Takeda
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A virus (IAV), and norovirus are global threats to human health. The application of effective virucidal agents, which contribute to the inactivation of viruses on hands and environmental surfaces, is important to facilitate robust virus infection control measures. Naturally derived virucidal disinfectants have attracted attention owing to their safety and eco-friendly properties. In this study, we showed that multiple Japanese Saxifraga species-derived fractions demonstrated rapid, potent virucidal activity against the SARS-CoV-2 ancestral strain and multiple variant strains, IAV, and two human norovirus surrogates: feline calicivirus (FCV) and murine norovirus (MNV)...
May 15, 2023: Applied and Environmental Microbiology
https://read.qxmd.com/read/37072183/the-pro-inflammatory-response-to-influenza-a-virus-infection-is-fueled-by-endothelial-cells
#12
JOURNAL ARTICLE
Lisa Bauer, Laurine C Rijsbergen, Lonneke Leijten, Feline Fw Benavides, Danny Noack, Mart M Lamers, Bart L Haagmans, Rory D de Vries, Rik L de Swart, Debby van Riel
Morbidity and mortality from influenza are associated with high levels of systemic inflammation. Endothelial cells play a key role in systemic inflammatory responses during severe influenza A virus (IAV) infections, despite being rarely infected in humans. How endothelial cells contribute to systemic inflammatory responses is unclear. Here, we developed a transwell system in which airway organoid-derived differentiated human lung epithelial cells were co-cultured with primary human lung microvascular endothelial cells (LMECs)...
July 2023: Life Science Alliance
https://read.qxmd.com/read/37049183/antiviral-activity-of-active-materials-standard-and-finger-pad-based-innovative-experimental-approaches
#13
JOURNAL ARTICLE
Lea Szpiro, Clara Bourgeay, Alexandre Loic Hoareau, Thomas Julien, Camille Menard, Yana Marie, Manuel Rosa-Calatrava, Vincent Moules
Environmental surfaces, including high-touch surfaces (HITS), bear a high risk of becoming fomites and can participate in viral dissemination through contact and transmission to other persons, due to the capacity of viruses to persist on such contaminated surface before being transferred to hands or other supports at sufficient concentration to initiate infection through direct contact. Interest in the development of self-decontaminating materials as additional safety measures towards preventing viral infectious disease transmission has been growing...
April 5, 2023: Materials
https://read.qxmd.com/read/36899059/inactivation-and-spike-protein-denaturation-of-novel-coronavirus-variants-by-cu-x-o-tio-2-nano-photocatalysts
#14
JOURNAL ARTICLE
Tetsu Tatsuma, Makoto Nakakido, Takeshi Ichinohe, Yoshinori Kuroiwa, Kengo Tomioka, Chang Liu, Nobuhiro Miyamae, Tatsuya Onuki, Kouhei Tsumoto, Kazuhito Hashimoto, Toru Wakihara
In order to reduce infection risk of novel coronavirus (SARS-CoV-2), we developed nano-photocatalysts with nanoscale rutile TiO2 (4-8 nm) and Cux O (1-2 nm or less). Their extraordinarily small size leads to high dispersity and good optical transparency, besides large active surface area. Those photocatalysts can be applied to white and translucent latex paints. Although Cu2 O clusters involved in the paint coating undergo gradual aerobic oxidation in the dark, the oxidized clusters are re-reduced under > 380 nm light...
March 10, 2023: Scientific Reports
https://read.qxmd.com/read/36669015/two-multiplex-pcr-methods-for-detecting-several-pathogens-associated-with-feline-respiratory-and-intestinal-tracts
#15
JOURNAL ARTICLE
Xiangyu Xiao, Xiangqi Hao, Bo Chen, Pei Zhou, Shoujun Li
Respiratory tract and intestinal diseases are common threats to feline health. Coinfection with multiple pathogens is not rare among clinical infectious cases. Rapid diagnosis of these coinfections is of great significance for timely and effective clinical treatment. In this study, two novel multiplex polymerase chain reactions (mPCRs) were established for simultaneous detection of four pathogens associated with the feline intestinal tract (feline coronavirus (FCoV), feline astrovirus (FeAstV), feline panleukopenia virus (FPV) and feline kobuvirus (FeKoV)) and five pathogens associated with the respiratory tract (feline calicivirus (FCV), feline herpesvirus 1 (FHV-1), feline leukemia virus (FeLV), Chlamydia felis ( C...
December 26, 2022: Veterinary Sciences
https://read.qxmd.com/read/35693765/investigating-influenza-virus-polymerase-activity-in-feline-cells-based-on-the-influenza-virus-minigenome-replication-system-driven-by-the-feline-rna-polymerase-i-promoter
#16
JOURNAL ARTICLE
Gang Lu, Feiyan Zheng, Jiajun Ou, Xin Yin, Shoujun Li
Emerging influenza virus poses a health threat to humans and animals. Domestic cats have recently been identified as a potential source of zoonotic influenza virus. The influenza virus minigenome replication system based on the ribonucleic acid (RNA) polymerase I (PolI) promoter is the most widely used tool for investigating polymerase activity. It could help determine host factors or viral proteins influencing influenza virus polymerase activity in vitro . However, influenza virus polymerase activity has never been studied in feline cells thus far...
2022: Frontiers in Immunology
https://read.qxmd.com/read/35633695/molecular-detection-of-parvovirus-in-captive-siberian-tigers-and-lions-in-northeastern-china-from-2019-to-2021
#17
JOURNAL ARTICLE
Shuping Huang, Xiang Li, Wei Xie, Lijun Guo, Dan You, Haitao Xu, Dan Liu, Yulong Wang, Zhijun Hou, Xiangwei Zeng, Siyuan Yang, Hongliang Chai, Yajun Wang
The fact that wild felines are carriers of pernicious infectious viruses should be a major concern due to the potential cross-species transmission between the felines and human or domestic animals. However, studies on the virus in the captive wild felines, especially in tigers, are thin on the ground. In this study, we screened four infectious viruses, namely, feline parvovirus (FPV), feline coronavirus (FCoV), canine distemper virus (CDV), and influenza A virus (IAV), in the blood samples of 285 captive Siberian tigers ( Panthera tigris altaica ) and in the spleen samples of two deceased lions ( Panthera leo ), which were collected from 2019 to 2021 in three Siberian Tiger Parks from the northeast of China...
2022: Frontiers in Microbiology
https://read.qxmd.com/read/35632832/adaptation-of-the-h7n2-feline-influenza-virus-to-human-respiratory-cell-culture
#18
JOURNAL ARTICLE
Wataru Sekine, Akiko Takenaka-Uema, Haruhiko Kamiki, Hiroho Ishida, Hiromichi Matsugo, Shin Murakami, Taisuke Horimoto
During 2016-2017, the H7N2 feline influenza virus infected more than 500 cats in animal shelters in New York, USA. A veterinarian who had treated the cats became infected with this feline virus and showed mild respiratory symptoms. This suggests that the H7N2 feline influenza virus may evolve into a novel pandemic virus with a high pathogenicity and transmissibility as a result of mutations in humans. In this study, to gain insight into the molecular basis of the transmission of the feline virus to humans, we selected mutant viruses with enhanced growth in human respiratory A549 cells via successive passages of the virus and found almost all mutations to be in the envelope glycoproteins, such as hemagglutinin (HA) and neuraminidase (NA)...
May 19, 2022: Viruses
https://read.qxmd.com/read/35538330/the-role-of-toothbrush-in-the-transmission-of-corona-and-influenza-viruses-results-of-an-in-vitro-study
#19
JOURNAL ARTICLE
Gerhard Schmalz, Laura Feindt, Franziska Tanneberger, Rainer Haak, Ahmed Abd El Wahed, Uwe Truyen, Dirk Ziebolz
OBJECTIVES: The aim of this in vitro study was to investigate viruses' stabilities on manual toothbrushes using feline coronavirus (FeCoV) as representative of coronaviruses and an Avian influenza A virus H1N1 for influenza viruses. MATERIAL AND METHODS: Two viruses, FeCoV (Strain Munich; titer 107.5 TCID50/ml) and H1N1 (RE 230/90; titer 106.5 TCID50/ml), were used in this study. Manual toothbrushes were disassembled into bristles, bristle fixation, and back of the toothbrush head, contaminated with the viruses and air-dried for 24 h...
September 2022: Clinical Oral Investigations
https://read.qxmd.com/read/35458393/emerging-respiratory-viruses-of-cats
#20
REVIEW
Andrea Palombieri, Federica Di Profio, Paola Fruci, Vittorio Sarchese, Vito Martella, Fulvio Marsilio, Barbara Di Martino
In recent years, advances in diagnostics and deep sequencing technologies have led to the identification and characterization of novel viruses in cats as protoparviruses and chaphamaparvoviruses, unveiling the diversity of the feline virome in the respiratory tract. Observational, epidemiological and experimental data are necessary to demonstrate firmly if some viruses are able to cause disease, as this information may be confounded by virus- or host-related factors. Also, in recent years, researchers were able to monitor multiple examples of transmission to felids of viruses with high pathogenic potential, such as the influenza virus strains H5N1, H1N1, H7N2, H5N6 and H3N2, and in the late 2019, the human hypervirulent coronavirus SARS-CoV-2...
March 23, 2022: Viruses
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