Julia Lederhofer, Yaroslav Tsybovsky, Lam Nguyen, Julie E Raab, Adrian Creanga, Tyler Stephens, Rebecca A Gillespie, Hubza Z Syeda, Brian E Fisher, Michelle Skertic, Christina Yap, Andrew J Schaub, Reda Rawi, Peter D Kwong, Barney S Graham, Adrian B McDermott, Sarah F Andrews, Neil P King, Masaru Kanekiyo
Continuously evolving influenza viruses cause seasonal epidemics and pose global pandemic threats. Although viral neuraminidase (NA) is an effective drug and vaccine target, our understanding of the NA antigenic landscape still remains incomplete. Here, we describe NA-specific human antibodies that target the underside of the NA globular head domain, inhibit viral propagation of a wide range of human H3N2, swine-origin variant H3N2, and H2N2 viruses, and confer both pre- and post-exposure protection against lethal H3N2 infection in mice...
February 28, 2024: Immunity