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Canine Influenza

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https://www.readbyqxmd.com/read/29127947/the-first-external-quality-assessment-of-isolation-and-identification-of-influenza-viruses-in-cell-culture-in-the-asia-pacific-region-2016
#1
Patrick C Reading, Vivian K Leung, Iwona Buettner, Leah Gillespie, Yi-Mo Deng, Robert Shaw, Natalie Spirason, Angela Todd, Aparna Singh Shah, Frank Konings, Ian G Barr
BACKGROUND: The isolation and propagation of influenza viruses from clinical specimens are essential tools for comprehensive virologic surveillance. Influenza viruses must be amplified in cell culture for detailed antigenic analysis and for phenotypic assays assessing susceptibility to antiviral drugs or for other assays. OBJECTIVES: To conduct an external quality assessment (EQA) of proficiency for isolation and identification of influenza viruses using cell culture techniques among National Influenza Centres (NICs) in the World Health Organisation (WHO) South East Asia and Western Pacific Regions...
November 2, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29118117/a-y161f-hemagglutinin-substitution-increases-thermostability-and-improves-yields-of-2009-h1n1-influenza-a-virus-in-cells
#2
Feng Wen, Lei Li, Nan Zhao, Meng-Jung Chiang, Hang Xie, Jim Cooley, Richard Webby, Peng George Wang, Xiu-Feng Wan
Vaccination is the primary strategy for influenza prevention and control. Yet egg-based vaccines, the predominant production platform, have several disadvantages including the emergence of viral antigenic variants that can be induced during egg passage. These limitations have prompted development of cell-based vaccines which themselves are not without issue. Most importantly, vaccine seed viruses often do not grow efficiently in mammalian cell lines. Here we aimed to identify novel high-yield signatures for influenza viruses in continuous Madin-Darby canine kidney (MDCK) and Vero cells...
November 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29104227/inter-species-host-gene-expression-differences-in-response-to-human-and-avian-influenza-a-virus-strains
#3
Biruhalem Taye, Dawn Yeo, Raphael Tze Chuen Lee, Boon Huan Tan, Richard J Sugrue, Sebastian Maurer-Stroh
Low pathogenic avian influenza (LPAI) viruses are a source of sporadic human infections and could also contribute to future pandemic outbreaks but little is known about inter-species differences in the host responses to these viruses. Here, we studied host gene expression signatures of cell lines from three species (human, chicken, and canine) in response to six different viruses (H1N1/WSN, H5N2/F59, H5N2/F118, H5N2/F189, H5N3 and H9N2). Comprehensive microarray probe set re-annotation and ortholog mapping of the host genes was necessary to allow comparison over extended functionally annotated gene sets and orthologous pathways...
November 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29093096/microrna-based-attenuation-of-influenza-virus-across-susceptible-hosts
#4
Barbara M Waring, Louisa E Sjaastad, Jessica K Fiege, Elizabeth J Fay, Ismarc Reyes, Branden Moriarity, Ryan A Langlois
Influenza A virus drives significant morbidity and mortality in humans and livestock. Annual circulation of the virus in livestock and waterfowl contributes to severe economic disruption and increases the risk of zoonotic transmission of novel strains into the human population where there is no preexisting immunity. Seasonal vaccinations in humans help prevent infection and can reduce symptoms when infection does occur. However, current vaccination regimens available for livestock are limited in part due to safety concerns regarding reassortment/recombination with circulating strains...
November 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29080615/antiviral-activity-of-five-asian-medicinal-pant-crude-extracts-against-highly-pathogenic-h5n1-avian-influenza-virus
#5
Benjaporn Sornpet, Teerapong Potha, Yingmanee Tragoolpua, Kidsadagon Pringproa
OBJECTIVE: To study the antiviral properties of the five Asian medicinal plants against in vitro infection by the highly pathogenic avian influenza virus (H5N1). METHODS: Crude extracts of Andrographis paniculata, Curcuma longa (C. longa), Gynostemma pentaphyllum, Kaempferia parviflora (K. parviflora), and Psidium guajava obtained by both water and ethanol extractions were investigated for their cytotoxicity in the Madin-Darby canine kidney cells. Thereafter, they were investigated in vitro for antiviral activity and cytokine response upon H5N1 virus infection...
September 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29074428/identification-and-function-analysis-of-canine-stimulator-of-interferon-gene-sting
#6
Yuxiang Zhang, Mengyan Zhu, Gairu Li, Jie Liu, Xiaofeng Zhai, Ruyi Wang, Junyan Zhang, Gang Xing, Jinyan Gu, Liping Yan, Jing Lei, Haifeng Sun, Zhiyu Shi, Fei Liu, Boli Hu, Shuo Su, Jiyong Zhou
Stimulator of interferon gene (STING) plays an important role in the cyclic GMP-AMP synthase (cGAS)-mediated activation of type I IFN responses. In this study, we identified and cloned canine STING gene. Full-length STING encodes a 375 amino acid product that shares the highest similarity with feline STING. Highest levels of mRNA of canine STING were detected in the spleen and lungs while the lowest levels in the heart and muscle. Analysis of its cellular localization showed that STING is localizes to the endoplasmic reticulum...
October 24, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29017603/longitudinal-study-of-influenza-a-virus-circulation-in-a-nursery-swine-barn
#7
Juliana B Ferreira, Helena Grgić, Robert Friendship, Greg Wideman, Éva Nagy, Zvonimir Poljak
Commercial production of swine often involves raising animals in large groups through the use of multi-stage production systems. In such systems, pigs can experience different degrees of contact with animals of the same or different ages. Population size and degree of contact can greatly influence transmission of endemic pathogens, including influenza A virus (IAV). IAV can display high genetic variability, which can further complicate population-level patterns. Yet, the IAV transmission in large multi-site swine production systems has not been well studied...
October 10, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28934454/assessment-of-molecular-antigenic-and-pathological-features-of-canine-influenza-a-h3n2-viruses-that-emerged-in-the-united-states
#8
Joanna A Pulit-Penaloza, Natosha Simpson, Hua Yang, Hannah M Creager, Joyce Jones, Paul Carney, Jessica A Belser, Genyan Yang, Jessie Chang, Hui Zeng, Sharmi Thor, Yunho Jang, Mary Lea Killian, Melinda Jenkins-Moore, Alicia Janas-Martindale, Edward Dubovi, David E Wentworth, James Stevens, Terrence M Tumpey, C Todd Davis, Taronna R Maines
Background: A single subtype of canine influenza virus (CIV), A(H3N8), was circulating in the United States until a new subtype, A(H3N2), was detected in Illinois in spring 2015. Since then, this CIV has caused thousands of infections in dogs in multiple states. Methods: In this study, genetic and antigenic properties of the new CIV were evaluated. In addition, structural and glycan array binding features of the recombinant hemagglutinin were determined. Replication kinetics in human airway cells and pathogenesis and transmissibility in animal models were also assessed...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28859269/optimized-clade-2-3-2-1c-h5n1-recombinant-vaccine-strains-against-highly-pathogenic-avian-influenza
#9
Jin-Wook Jang, Chung-Young Lee, Il-Hwan Kim, Jun-Gu Choi, Youn-Jeong Lee, Seong-Su Yuk, Ji-Ho Lee, Chang-Seon Song, Jae-Hong Kim, Hyuk-Joon Kwon
A/Puerto Rico/8/34 (PR8)-derived recombinant viruses have been used for seasonal flu vaccines; however, they are insufficient for vaccines against some human-fatal H5N1 highly pathogenic avian influenza (HPAI) viruses (HPAIV) due to low productivity. Additionally, the polymerase basic 2 (PB2) protein, an important mammalian-pathogenicity determinant, of PR8 possesses several mammalian-pathogenic mutations. We previously reported two avian PB2 genes (01310 and 0028) related to efficient replication in embryonated chicken eggs (ECEs) and nonpathogenicity in BALB/c mice...
August 31, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28858604/spread-of-canine-influenza-a-h3n2-virus-united-states
#10
Ian E H Voorhees, Amy L Glaser, Kathy Toohey-Kurth, Sandra Newbury, Benjamin D Dalziel, Edward J Dubovi, Keith Poulsen, Christian Leutenegger, Katriina J E Willgert, Laura Brisbane-Cohen, Jill Richardson-Lopez, Edward C Holmes, Colin R Parrish
A canine influenza A(H3N2) virus emerged in the United States in February-March 2015, causing respiratory disease in dogs. The virus had previously been circulating among dogs in Asia, where it originated through the transfer of an avian-origin influenza virus around 2005 and continues to circulate. Sequence analysis suggests the US outbreak was initiated by a single introduction, in Chicago, of an H3N2 canine influenza virus circulating among dogs in South Korea in 2015. Despite local control measures, the virus has continued circulating among dogs in and around Chicago and has spread to several other areas of the country, particularly Georgia and North Carolina, although these secondary outbreaks appear to have ended within a few months...
December 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28835506/the-k186e-amino-acid-substitution-in-the-canine-influenza-virus-h3n8-ns1-protein-restores-its-ability-to-inhibit-host-gene-expression
#11
Aitor Nogales, Caroline Chauché, Marta L DeDiego, David J Topham, Colin R Parrish, Pablo R Murcia, Luis Martínez-Sobrido
Canine influenza viruses (CIVs) are the causative agents of canine influenza, a contagious respiratory disease in dogs, and include the equine-origin H3N8 and the avian-origin H3N2 viruses. Influenza A virus (IAV) nonstructural protein 1 (NS1) is a virulence factor essential for counteracting the innate immune response. Here, we evaluated the ability of H3N8 CIV NS1 to inhibit host innate immune responses. We found that H3N8 CIV NS1 was able to efficiently counteract interferon (IFN) responses but was unable to block general gene expression in human or canine cells...
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28814512/zoonotic-risk-pathogenesis-and-transmission-of-avian-origin-h3n2-canine-influenza-virus
#12
Hailiang Sun, Sherry Blackmon, Guohua Yang, Kaitlyn Waters, Tao Li, Ratanaporn Tangwangvivat, Yifei Xu, Daniel Shyu, Feng Wen, Jim Cooley, Lucy Senter, Xiaoxu Lin, Richard Jarman, Larry Hanson, Richard Webby, Xiu-Feng Wan
Two subtypes of influenza A virus (IAV), avian-origin canine influenza virus (CIV) H3N2 (CIV-H3N2) and equine-origin CIV H3N8 (CIV-H3N8), are enzootic in the canine population. Dogs have been demonstrated to seroconvert in response to diverse IAVs, and naturally occurring reassortants of CIV-H3N2 and the 2009 H1N1 pandemic virus (pdmH1N1) have been isolated. We conducted a thorough phenotypic evaluation of CIV-H3N2 in order to assess its threat to human health. Using ferret-generated antiserum, we determined that CIV-H3N2 is antigenically distinct from contemporary human H3N2 IAVs, suggesting that there may be minimal herd immunity in humans...
November 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28777309/biological-evaluation-of-uridine-derivatives-of-2-deoxy-sugars-as-potential-antiviral-compounds-against-influenza-a-virus
#13
Ewelina Krol, Ilona Wandzik, Martyna Krejmer-Rabalska, Boguslaw Szewczyk
Influenza virus infection is a major cause of morbidity and mortality worldwide. Due to the limited ability of currently available treatments, there is an urgent need for new anti-influenza drugs with broad spectrum protection. We have previously shown that two 2-deoxy sugar derivatives of uridine (designated IW3 and IW7) targeting the glycan processing steps during maturation of viral glycoproteins show good anti-influenza virus activity and may be a promising alternative approach for the development of new anti-influenza therapy...
August 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28757141/molecular-epidemiology-of-a-novel-re-assorted-epidemic-strain-of-equine-influenza-virus-in-pakistan-in-2015-16
#14
Amjad Khan, Muhammad Hassan Mushtaq, Mansur Ud Din Ahmad, Jawad Nazir, Shahid Hussain Farooqi, Asghar Khan
BACKGROUND: A widespread epidemic of equine influenza (EI) occurred in nonvaccinated equine population across multiple districts in Khyber Pakhtunkhwa Province of Pakistan during 2015-2016. OBJECTIVES AND METHODS: An epidemiological surveillance study was conducted from Oct 2015 to April 2016 to investigate the outbreak. EI virus strains were isolated in embryonated eggs from suspected equines swab samples and were subjected to genome sequencing using M13 tagged segment specific primers...
July 27, 2017: Virus Research
https://www.readbyqxmd.com/read/28751224/molecular-cloning-and-functional-characterization-of-eleven-subtypes-of-interferon-%C3%AE-in-amur-tigers-panthera-tigris-altaica
#15
Hongjing Zhao, Jian Ma, Yu Wang, Juanjuan Liu, Yizhi Shao, Jinglun Li, Guangshun Jiang, Mingwei Xing
Interferon has a broad-spectrum of antiviral effects and represents an ideal choice for the development of antiviral drugs. Nonetheless, information about alpha interferon (IFN-α) is vacant in Amur tiger (Panthera tigris altaica), an endangered species and indigenous to northeast Asia. Herein, 11 PtIFN-αs genes, which encoded proteins of 164-165 amino acids, were amplified. Afterwards, expression and purification were conducted in Escherichia coli. In physicochemical analysis, PtIFN-αs were shown to be highly sensitive to trypsin and remained stable despite changes in pH and temperature...
July 24, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28714491/molecular-epidemiology-and-antigenic-characterization-of-seasonal-influenza-viruses-circulating-in-nepal
#16
B P Upadhyay, P Ghimire, M Tashiro, M R Banjara
BACKGROUND: Influenza is one of the public health burdens in Nepal and its epidemiology is not clearly understood. The objective of this study was to explore the molecular epidemiology and the antigenic characteristics of the circulating influenza viruses in Nepal. METHODS: A total of 1495 throat swab specimens were collected from January to December, 2014. Real time PCR assay was used for identification of influenza virus types and subtypes. Ten percent of the positive specimens were randomly selected and inoculated onto Madin-Darby Canine Kidney Epithelial cells (MDCK) for influenza virus isolation...
January 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28709557/a-bivalent-live-attenuated-influenza-vaccine-for-the-control-and-prevention-of-h3n8-and-h3n2-canine-influenza-viruses
#17
Laura Rodriguez, Aitor Nogales, Pablo R Murcia, Colin R Parrish, Luis Martínez-Sobrido
Canine influenza viruses (CIVs) cause a contagious respiratory disease in dogs. CIV subtypes include H3N8, which originated from the transfer of H3N8 equine influenza virus (EIV) to dogs; and the H3N2, which is an avian-origin virus adapted to infect dogs. Only inactivated influenza vaccines (IIVs) are currently available against the different CIV subtypes. However, the efficacy of these CIV IIVs is not optimal and improved vaccines are necessary for the efficient prevention of disease caused by CIVs in dogs...
July 11, 2017: Vaccine
https://www.readbyqxmd.com/read/28685290/suspension-culture-process-for-h9n2-avian-influenza-virus-strain-re-2
#18
Honglin Wang, Suying Guo, Zhenguang Li, Xiaoqin Xu, Zexiang Shao, Guicai Song
H9N2 avian influenza virus has caused huge economic loss for the Chinese poultry industry since it was first identified. Vaccination is frequently used as a control method for the disease. Meanwhile suspension culture has become an important tool for the development of influenza vaccines. To optimize the suspension culture conditions for the avian influenza H9N2 virus (Re-2 strain) in Madin-Darby Canine Kidney (MDCK) cells, we studied the culture conditions for cell growth and proliferation parameters for H9N2 virus replication...
July 7, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28674259/pinanamine-is-a-promising-lead-compound-against-influenza-a-virus-evidence-from-in-vitro-and-in-vivo-efficacy-compared-to-amantadine
#19
Runfeng Li, Chunguang Yang, Qiuling Du, Xin Zhao, Haiming Jiang, Wenhui Hu, Zifeng Yang
Influenza A viruses with the presence of mutations in M2 still circulate and threaten to avian species and human in China. A novel M2 inhibitor pinanamine was previously identified as an antiviral agent by an in vitro assay. In this study, we monitored the activity of pinanamine against influenza A/FM1/47 (H1N1) virus infection in cell culture and mice. Pinanamine showed more potent antiviral effect than ribavirin, and was as effective as oseltamivir carboxylate and amantadine in Madin-Darby canine kidney (MDCK) cells...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28668573/safety-and-immunogenicity-of-an-inactivated-cell-culture-derived-h7n9-influenza-vaccine-in-healthy-adults-a-phase-i-ii-prospective-randomized-open-label-trial
#20
Un-In Wu, Szu-Min Hsieh, Wen-Sen Lee, Ning-Chi Wang, Hsiang-Chi Kung, Tsong-Yih Ou, Fu-Lun Chen, Te-Yu Lin, Yee-Chun Chen, Shan-Chwen Chang
BACKGROUND: We conducted a phase I/II clinical trial to evaluate the safety and immunogenicity of a Madin-Darby canine kidney (MDCK) cell-grown inactivated H7N9 influenza vaccine for pandemic preparedness purposes. METHODS: Between April 7, 2015 and May 27, 2016, healthy adults aged 20-60years were enrolled sequentially in phase I (n=40) and phase II (n=160) from three hospitals in Taiwan and randomized to receive 2 doses of whole-virus H7N9 vaccine (15 or 30μg hemagglutinin antigen (HA) with or without an aluminum hydroxide adjuvant) at 21-day intervals...
June 28, 2017: Vaccine
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