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Canine Influenza

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https://www.readbyqxmd.com/read/28282885/anti-influenza-virus-h5n1-activity-screening-on-the-phloroglucinols-from-rhizomes-of-dryopteris-crassirhizoma
#1
Juan Wang, Yan-Tao Yan, Shen-Zhen Fu, Bing Peng, Lin-Lin Bao, Yan-Ling Zhang, Jing-Hong Hu, Zu-Ping Zeng, Dong-Hao Geng, Zeng-Ping Gao
For screening the active phloroglucinols on influenza virus (H5N1) from Dryopteris crassirhizoma NaKai, a database was established including twenty-three phloroglucinols that had been isolated from Dryopteris crassirhizoma. Their inhibitory effect on the neuraminidase (NA) of influenza virus H5N1 was screened by molecular docking. As a result, three candidates were selected. The rhizomes of D. crassirhizoma were subjected to isolation and purification processes to obtain the inhibitor candidates. Thirteen phloroglucinols were obtained, including three selected candidates and two new phloroglucinols...
March 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28272019/geniposide-demonstrates-anti-inflammatory-and-antiviral-activity-against-pandemic-a-jiangsu-1-2009-h1n1-influenza-virus-infection-in-vitro-and-in-vivo
#2
Zhang Yunshi, Yao Jing, Qi Xian, Liu Xing, Lu Xieqin, Feng Ganzhu
BACKGROUND: Influenza A viruses (IAVs) remains to be a great threat to human health for centuries, without effective control. Geniposide, a main iridoid glycoside compound extracted from Gardenia jasminoides Ellis (GJ) fruit, possesses various biologic activities including anti-inflammation and anti-virus. METHODS: Madin-Darby Canine Kidney (MDCK) cells were infected with pandemic A/Jiangsu/1/2009 (H1N1) influenza virus in vitro. Cytotoxicity and antiviral activity of geniposide were estimated by MTT assay...
March 8, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28271163/molecular-characterization-of-neuraminidase-genes-of-influenza-a-h3n2-viruses-circulating-in-southwest-india-from-2009-to-2013
#3
Anitha Jagadesh, Abdul Ajees Abdul Salam, Vahid Rajabali Zadeh, Anjana Krishnan, Govindakarnavar Arunkumar
Molecular characterization of neuraminidase (NA) gene of 25 influenza A(H3N2) virus isolates (2009-2013) archived at the Manipal Centre for Virus Research was carried out. The annual rate of amino acid substitutions in the N2 gene of influenza A(H3N2) virus isolates was 0.2-0.6%. Out of the 25 NA sequences analyzed, catalytic site mutations were observed in three isolates. Two of the mutations (D151G and E276G) were detected in functional catalytic residues, and an E227V mutation was detected in the framework residues...
March 7, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28237237/expanding-veterinary-biosurveillance-in-washington-dc-the-creation-and-utilization-of-an-electronic-based-online-veterinary-surveillance-system
#4
Andrew Hennenfent, Vito DelVento, John Davies-Cole, Fern Johnson-Clarke
OBJECTIVES: To enhance the early detection of emerging infectious diseases and bioterrorism events using companion animal-based surveillance. METHODS: Washington, DC, small animal veterinary facilities (n=17) were surveyed to determine interest in conducting infectious disease surveillance. Using these results, an electronic-based online reporting system was developed and launched in August 2015 to monitor rates of canine influenza, canine leptospirosis, antibiotic resistant infections, canine parvovirus, and syndromic disease trends...
March 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28207898/distinct-susceptibility-and-applicability-of-mdck-derivatives-for-influenza-virus-research
#5
Shih-Chao Lin, Matthew A Kappes, Mei-Chun Chen, Chi-Chen Lin, Tony T Wang
Madin-Darby Canine Kidney (MDCK) cells are widely utilized as a substrate for influenza virus isolation and propagation due to the high yields of virus. Here we compared the conventional MDCK cell line, MDCK-SIAT1 and MDCK-London for viral production, cell survival, and suitability in testing antivirals using six influenza strains including two H1N1 (pandemic and epidemic strains), three H3N2 and one influenza B strain. Overall our results suggest that MDCK-London cell line is superior for virus culturing and quantification, and hence an ideal platform to evaluate antiviral drug efficacy against multiple strains of influenza...
2017: PloS One
https://www.readbyqxmd.com/read/28173854/anti-influenza-virus-activity-of-extracts-from-the-stems-of-jatropha-multifida-linn-collected-in-myanmar
#6
Masaki Shoji, So-Yeun Woo, Aki Masuda, Nwet Nwet Win, Hla Ngwe, Etsuhisa Takahashi, Hiroshi Kido, Hiroyuki Morita, Takuya Ito, Takashi Kuzuhara
BACKGROUND: To contribute to the development of novel anti-influenza drugs, we investigated the anti-influenza activity of crude extracts from 118 medicinal plants collected in Myanmar. We discovered that extract from the stems of Jatropha multifida Linn. showed anti-influenza activity. J. multifida has been used in traditional medicine for the treatment of various diseases, and the stem has been reported to possess antimicrobial, antimalarial, and antitumor activities. However, the anti-influenza activity of this extract has not yet been investigated...
February 7, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28167384/a-live-attenuated-influenza-vaccine-for-h3n2-canine-influenza-virus
#7
Laura Rodriguez, Aitor Nogales, Emma C Reilly, David J Topham, Pablo R Murcia, Colin R Parrish, Luis Martinez Sobrido
Canine influenza is a contagious respiratory disease in dogs caused by two subtypes (H3N2 and H3N8) of canine influenza virus (CIV). Currently, only inactivated influenza vaccines (IIVs) are available for the prevention of CIVs. Historically, live-attenuated influenza vaccines (LAIVs) have been shown to produce better immunogenicity and protection efficacy than IIVs. Here, we have engineered a CIV H3N2 LAIV by using the internal genes of a previously described CIV H3N8 LAIV as a master donor virus (MDV) and the surface HA and NA genes of a circulating CIV H3N2 strain...
February 3, 2017: Virology
https://www.readbyqxmd.com/read/28161578/consensus-m2e-peptide-conjugated-to-gold-nanoparticles-confers-protection-against-h1n1-h3n2-and-h5n1-influenza-a-viruses
#8
Wenqian Tao, Brett L Hurst, Akhilesh Kumar Shakya, Md Jasim Uddin, Rohan S J Ingrole, Mayra Hernandez-Sanabria, Ravi P Arya, Lynn Bimler, Silke Paust, E Bart Tarbet, Harvinder Singh Gill
The extracellular domain of influenza A ion channel membrane matrix protein 2 (M2e) is considered to be a potential candidate to develop a universal influenza A vaccine. However poor immunogenicity of M2e presents a significant roadblock. We have developed a vaccine formulation comprising of the consensus M2e peptide conjugated to gold nanoparticles (AuNPs) with CpG as a soluble adjuvant (AuNP-M2e + sCpG). We demonstrate that intranasal delivery of AuNP-M2e + sCpG in mice induces lung B cell activation and robust serum anti-M2e immunoglobulin G (IgG) response, with stimulation of both IgG1 and IgG2a subtypes...
February 2, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28147362/hochuekkito-a-japanese-herbal-medicine-restores-metabolic-homeostasis-between-mitochondrial-and-glycolytic-pathways-impaired-by-influenza-a-virus-infection
#9
Keita Takanashi, Katsuaki Dan, Sho Kanzaki, Hideki Hasegawa, Kenji Watanabe, Kaoru Ogawa
BACKGROUND: Hochuekkito (HKT), a traditional Japanese herbal medicine (Kampo), has been used to treat symptoms of several diseases. In a recent clinical study, HKT was shown to be protective against the influenza virus infection. However, the underlying mechanism of the prophylactic effect is not clear. Mitochondrial and glycolytic pathways play important roles in cellular energy metabolism to maintain biological functions. These metabolic pathways are affected by the influenza virus infection...
February 2, 2017: Pharmacology
https://www.readbyqxmd.com/read/28128091/development-of-oseltamivir-and-zanamivir-resistance-in-influenza-a-h1n1-pdm09-virus-denmark-2014
#10
Ramona Trebbien, Svend Stenvang Pedersen, Kristine Vorborg, Kristina Træholt Franck, Thea Kølsen Fischer
Antiviral treatment of immunocompromised patients with prolonged influenza virus infection can lead to multidrug resistance. This study reveals the selection of antiviral resistance mutations in influenza A(H1N1)pdm09 virus in an immunocompromised patient during a 6-month period. The patient was treated with two courses of oseltamivir (5 days and 2 months, respectively), with the first course starting at symptom onset, and subsequently zanamivir (2 months and 10 days, respectively). Respiratory samples were investigated by Sanger and next generation sequencing (NGS) and, for NGS data, low-frequency-variant-detection analysis was performed...
January 19, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28119097/aurantiamide-acetate-from-baphicacanthus-cusia-root-exhibits-anti-inflammatory-and-anti-viral-effects-via-inhibition-of-the-nf-%C3%AE%C2%BAb-signaling-pathway-in-influenza-a-virus-infected-cells
#11
Beixian Zhou, Zifeng Yang, Qitong Feng, Xiaoli Liang, Jing Li, Mark Zanin, Zhihong Jiang, Nanshan Zhong
ETHNOPHARMACOLOGICAL RELEVANCE: Baphicacanthus cusia root also names "Nan Ban Lan Gen" has been traditionally used to prevent and treat influenza A virus infections. Here, we identified a peptide derivative, aurantiamide acetate (compound E17), as an active compound in extracts of B. cusia root. Although studies have shown that aurantiamide acetate possesses antioxidant and anti-inflammatory properties, the effects and mechanism by which it functions as an anti-viral or as an anti-inflammatory during influenza virus infection are poorly defined...
January 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28107507/a-multiplex-rt-pcr-assay-for-detection-and-differentiation-of-avian-origin-canine-h3n2-equine-origin-h3n8-human-origin-h3n2-and-h1n1-2009-canine-influenza-viruses
#12
Chenxi Wang, Qian Wang, Junyi Hu, Honglei Sun, Juan Pu, Jinhua Liu, Yipeng Sun
Virological and serological surveys have documented that H1N1/2009, avian-origin canine H3N2 (cH3N2), seasonal human-origin H3N2 (hH3N2), and equine-origin H3N8 influenza viruses are consistently circulating in dogs. In the present study, a multiplex reverse-transcriptase polymerase chain reaction (mRT-PCR) assay was developed for simultaneous detection and differentiation of these influenza viruses. Four primer sets were designed to target the hemagglutinin genes of H1N1/2009, cH3N2, hH3N2, and H3N8 canine influenza viruses (CIVs)...
2017: PloS One
https://www.readbyqxmd.com/read/28089070/steric-exclusion-chromatography-for-purification-of-cell-culture-derived-influenza-a-virus-using-regenerated-cellulose-membranes-and-polyethylene-glycol
#13
Pavel Marichal-Gallardo, Michael M Pieler, Michael W Wolff, Udo Reichl
Steric exclusion chromatography has been used for the purification of proteins and bacteriophages using monoliths. The operation is carried out by mixing a crude sample containing the target species with a predetermined concentration and molecular weight of polyethylene glycol (PEG) and loading it onto a non-reactive hydrophilic surface. Product capture occurs by the mutual steric exclusion of PEG between the product and the matrix. Selectivity is significantly influenced by target product size. Product elution is achieved by decreasing the PEG concentration...
December 29, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28069171/steric-exclusion-chromatography-for-purification-of-cell-culture-derived-influenza-a-virus-using-regenerated-cellulose-membranes-and-polyethylene-glycol
#14
Pavel Marichal-Gallardo, Michael M Pieler, Michael W Wolff, Udo Reichl
Steric exclusion chromatography has been used for the purification of proteins and bacteriophages using monoliths. The operation is carried out by mixing a crude sample containing the target species with a predetermined concentration and molecular weight of polyethylene glycol (PEG) and loading it onto a non-reactive hydrophilic surface. Product capture occurs by the mutual steric exclusion of PEG between the product and the matrix. Selectivity is significantly influenced by target product size. Product elution is achieved by decreasing the PEG concentration...
February 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28004398/detection-of-d151g-n-mutations-in-the-neuraminidase-gene-of-influenza-a-h3n2-viruses-by-real-time-rt-pcr-allelic-discrimination-assay
#15
Vahid Rajabali Zadeh, Anitha Jagadesh, Anjana Krishnan, Govindakarnavar Arunkumar
Single nucleotide polymorphisms (SNPs) at D151 position of neuraminidase (NA) gene of influenza A (H3N2) virus has been associated with drug resistance and increased binding affinity. NA-D151G/N-substitutions of influenza A (H3N2) viruses are frequently induced and selected by culturing in Madin-Darby canine kidney (MDCK) cell lines. It is important to consider and exclude D151G/N mutants after isolation of influenza virus in MDCK cell line; since, the substitutions can highly influence the results of experimental research...
December 22, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27928017/temperature-sensitive-live-attenuated-canine-influenza-virus-h3n8-vaccine
#16
Aitor Nogales, Laura Rodriguez, Caroline Chauché, Kai Huang, Emma C Reilly, David J Topham, Pablo R Murcia, Colin R Parrish, Luis Martínez-Sobrido
Canine influenza is a respiratory disease of dogs caused by canine influenza virus (CIV). CIV subtypes responsible for influenza in dogs include H3N8, which originated from the transfer of H3N8 equine influenza virus to dogs; and the H3N2 CIV, which is an avian-origin virus that adapted to infect dogs. Influenza infections are most effectively prevented through vaccination to reduce transmission and future infection. Currently, only inactivated influenza vaccines (IIVs) are available for the prevention of CIV in dogs...
February 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/27881069/anti-influenza-virus-effects-of-catechins-a-molecular-and-clinical-review
#17
REVIEW
Kazuke Ide, Yohei Kawasaki, Koji Kawakami, Hiroshi Yamada
Influenza infection and associated epidemics represent a serious public health problem. Several preventive and curative measures exist against its spread including vaccination and therapeutic agents such as neuraminidase inhibitors (e.g., oseltamivir, zanamivir, as well as peramivir and laninamivir, which are licensed in several countries) and adamantanes (e.g., amantadine and rimantadine). However, neuraminidase inhibitor- and adamantane- resistant viruses have been detected, whereas vaccines exhibit strain-specific effects and are limited in supply...
2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27816372/a-cell-culture-derived-whole-virus-influenza-a-vaccine-based-on-magnetic-sulfated-cellulose-particles-confers-protection-in-mice-against-lethal-influenza-a-virus-infection
#18
Michael M Pieler, Sarah Frentzel, Dunja Bruder, Michael W Wolff, Udo Reichl
Downstream processing and formulation of viral vaccines employs a large number of different unit operations to achieve the desired product qualities. The complexity of individual process steps involved, the need for time consuming studies towards the optimization of virus yields, and very high requirements regarding potency and safety of vaccines results typically in long lead times for the establishment of new processes. To overcome such obstacles, to enable fast screening of potential vaccine candidates, and to explore options for production of low cost veterinary vaccines a new platform for whole virus particle purification and formulation based on magnetic particles has been established...
December 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27799877/genetic-characteristics-and-immunogenicity-of-pandemic-h1n1-influenza-virus-isolate-from-pig-in-korea
#19
Hyoung Joon Moon, Jin Sik Oh, Woonsung Na, Minjoo Yeom, Sang Yoon Han, Sung Jae Kim, Bong Kyun Park, Dae Sub Song, Bo Kyu Kang
A pandemic influenza A (H1N1) virus strain was isolated from a pig farm in Korea in December 2009. The strain was propagated in and isolated from both the Madin-Darby canine kidney cell line and embryonated eggs. The partial and complete sequences of the strain were identical to those of A/California/04/2009, with >99% sequence similarity in the HA, NA, M, NS, NP, PA, PB1, and PB2 genes. The isolated strain was inactivated and used to prepare a swine influenza vaccine. This trial vaccine, containing the new isolate that has high sequence similarity with the pandemic influenza A (H1N1) virus, resulted in seroconversion in Guinea pigs and piglets...
October 2016: Immune Network
https://www.readbyqxmd.com/read/27791106/synthetically-derived-bat-influenza-a-like-viruses-reveal-a-cell-type-but-not-species-specific-tropism
#20
Étori Aguiar Moreira, Samira Locher, Larissa Kolesnikova, Hardin Bolte, Teresa Aydillo, Adolfo García-Sastre, Martin Schwemmle, Gert Zimmer
Two novel influenza A-like viral genome sequences have recently been identified in Central and South American fruit bats and provisionally designated "HL17NL10" and "HL18NL11." All efforts to isolate infectious virus from bats or to generate these viruses by reverse genetics have failed to date. Recombinant vesicular stomatitis virus (VSV) encoding the hemagglutinin-like envelope glycoproteins HL17 or HL18 in place of the VSV glycoprotein were generated to identify cell lines that are susceptible to bat influenza A-like virus entry...
October 24, 2016: Proceedings of the National Academy of Sciences of the United States of America
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