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Canine Influenza

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https://www.readbyqxmd.com/read/29783993/cirsimaritin-inhibits-influenza-a-virus-replication-by-downregulating-the-nf-%C3%AE%C2%BAb-signal-transduction-pathway
#1
Haiyan Yan, Huiqiang Wang, Linlin Ma, Xueping Ma, Jinqiu Yin, Shuo Wu, Hua Huang, Yuhuan Li
BACKGROUND: Artemisia scoparia Waldst and Kit is a famous traditional Chinese medicine widely distributed in Xinjiang, China. Flavonoids extracted from it exhibits inhibitory activities against several influenza virus strains. Despite this fact, the antiviral properties of CST, one of such flavonoids, against the influenza virus has not been reported. Thus, the aim of this study is to investigate the anti-influenza virus efficacy and antiviral mechanism of CST. METHODS: The inhibitory activity of CST against influenza viruses was assessed by using viral titers and performing Western blot, qRT-PCR, and immunofluorescence assays in Madin-Darby canine kidney (MDCK) cells and a human monocytic cell line (THP-1)...
May 21, 2018: Virology Journal
https://www.readbyqxmd.com/read/29772263/comparative-analysis-of-microrna-expression-in-dog-lungs-infected-with-the-h3n2-and-h5n1-canine-influenza-viruses
#2
Yun Zheng, Xinliang Fu, Lifang Wang, Wenyan Zhang, Pei Zhou, Xin Zhang, Weijie Zeng, Jidang Chen, Zongxi Cao, Kun Jia, Shoujun Li
MicroRNAs, a class of noncoding RNAs 18 to 23 nucleotides (nt) in length, play critical roles in a wide variety of biological processes. The objective of this study was to examine differences in microRNA expression profiles derived from the lungs of beagle dogs infected with the avian-origin H3N2 canine influenza virus (CIV) or the highly pathogenic avian influenza (HPAI) H5N1 virus (canine-origin isolation strain). After dogs were infected with H3N2 or H5N1, microRNA expression in the lungs was assessed using a deep-sequencing approach...
May 14, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29716608/comparison-of-the-virulence-of-three-h3n2-canine-influenza-virus-isolates-from-korea-and-china-in-mouse-and-guinea-pig-models
#3
Xing Xie, Woonsung Na, Aram Kang, Minjoo Yeom, Heejun Yuk, Hyoungjoon Moon, Sung-Jae Kim, Hyun-Woo Kim, Jeong-Ki Kim, Maoda Pang, Yongshan Wang, Yongjie Liu, Daesub Song
BACKGROUND: Avian-origin H3N2 canine influenza virus (CIV) has been the most common subtype in Korea and China since 2007. Here, we compared the pathogenicity and transmissibility of three H3N2 CIV strains [Chinese CIV (JS/10), Korean CIV (KR/07), and Korean recombinant CIV between the classic H3N2 CIV and the pandemic H1N1 virus (MV/12)] in BALB/c mouse and guinea pig models. The pandemic H1N1 (CA/09) strain served as the control. RESULTS: BALB/c mice infected with H1N1 had high mortality and obvious body weight loss, whereas no overt disease symptoms were observed in mice inoculated with H3N2 CIV strains...
May 2, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29691381/genetic-and-evolutionary-analysis-of-emerging-h3n2-canine-influenza-virus
#4
Gairu Li, Ruyi Wang, Cheng Zhang, Shilei Wang, Wanting He, Junyan Zhang, Jie Liu, Yuchen Cai, Jiyong Zhou, Shuo Su
The H3N2 canine influenza virus (CIV) originated from an avian species. Since its emergence, it has circulated in multiple states and has caused pandemics among dog populations; however, no comprehensive studies have explored the causes driving these ongoing cases. The study of the codon usage patterns of viruses can reveal the genetic changes required for the viruses to adapt to new hosts and the external environment. Here we performed a thorough genetic, evolutionary, and codon usage analysis. We identified three evolutionary H3N2 CIV clades from a timescaled phylogenetic tree, namely, Origin, China, and Korea/USA, by principal component analysis (PCA)...
April 25, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29662313/inhibition-of-h1n1-influenza-virus-induced-apoptosis-by-functionalized-selenium-nanoparticles-with-amantadine-through-ros-mediated-akt-signaling-pathways
#5
Yinghua Li, Zhengfang Lin, Min Guo, Mingqi Zhao, Yu Xia, Changbing Wang, Tiantian Xu, Bing Zhu
Introduction: As a therapeutic antiviral agent, the clinical application of amantadine (AM) is limited by the emergence of drug-resistant viruses. To overcome the drug-resistant viruses and meet the growing demand of clinical diagnosis, the use of biological nanoparticles (NPs) has increased in order to develop novel anti-influenza drugs. The antiviral activity of selenium NPs with low toxicity and excellent activities has attracted increasing attention for biomedical intervention in recent years...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29626767/environmental-contaminant-mixtures-modulate-in-vitro-influenza-infection
#6
Jean-Pierre Desforges, Christopher Bandoro, Laila Shehata, Christian Sonne, Rune Dietz, Wendy B Puryear, Jonathan A Runstadler
Environmental chemicals, particularly organochlorinated contaminants (OCs), are associated with a ranged of adverse health effects, including impairment of the immune system and antiviral immunity. Influenza A virus (IAV) is an infectious disease of major global public health concern and exposure to OCs can increase the susceptibility, morbidity, and mortality to disease. It is however unclear how pollutants are interacting and affecting the outcome of viral infections at the cellular level. In this study, we investigated the effects of a mixture of environmentally relevant OCs on IAV infectivity upon in vitro exposure in Madin Darby Canine Kidney (MDCK) cells and human lung epithelial cells (A549)...
April 4, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29616305/polyunsaturated-fatty-acids-from-phyllocaulis-boraceiensis-mucus-block-the-replication-of-influenza-virus
#7
Ana Rita de Toledo-Piza, Maria Isabel de Oliveira, Giuseppina Negri, Ronaldo Zucatelli Mendonça, Cristina Adelaide Figueiredo
Influenza viruses cause worldwide outbreaks and pandemics in humans and animals every year with considerable morbidity and mortality. The molecular diversity of secondary metabolites extracted from mollusks is a good alternative for the discovery of novel bioactive compounds with unique structures and diverse biological activities. Phyllocaulis boraceiensis is a hermaphroditic slug that exudes mucus, in which was detected hydroxy polyunsaturated fatty acids that exhibited potent antiviral activity against measles virus...
April 3, 2018: Archives of Microbiology
https://www.readbyqxmd.com/read/29600623/-effect-and-mechanism-of-mahuang-tang-against-influenza-a-h1n1-virus-in-vitro
#8
Wen-Yang Wei, Hai-Tong Wan, Li Yu, Yi-Yu Lu, Yu He
To study the effect and underlying mechanism of Mahuang Tang against influenza A virus in vitro , the influenza virus-infected Madin-Darby canine kidney(MDCK) cells were used as the carrier in this study to detect the median tissue culture-infective dose(TCID₅₀) of influenza A virus strains(A/PR8/34) on MDCK cells with cytopathic effect(CPE) assay. Blocking influenza virus invading host cells and anti-influenza virus biosynthesis were used as two different administration methods, and then the methyl thiazolyl tetrazolium(MTT) assay was utilized to determine the antiviral effective rate(ER), median efficacious concentration(EC₅₀) and therapeutic index(TI) of Mahuang Tang...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29595386/outcomes-of-and-risk-factors-for-presumed-canine-h3n2-influenza-virus-infection-in-a-metropolitan-outbreak
#9
Danielle Dunn, Kate E Creevy, Paula M Krimer
OBJECTIVE To determine clinical signs, case fatality rate, and factors associated with positive results of PCR testing for canine influenza virus (CIV) in dogs during an H3N2 CIV outbreak in the Atlanta area. DESIGN Cross-sectional study. ANIMALS 220 dogs with a nasal swab specimen submitted to an Atlanta-area diagnostic laboratory between May 1 and July 2, 2015, for PCR assay detection of CIV specifically or CIV and 5 other respiratory pathogens. PROCEDURES Veterinarians of tested dogs were surveyed by various means to collect information regarding clinical signs, survival status at the time of survey completion, vaccination history (≤ 12 months prior to testing), and travel history (≤ 2 months prior to testing)...
April 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29593063/erratum-for-sun-et-al-zoonotic-risk-pathogenesis-and-transmission-of-avian-origin-h3n2-canine-influenza-virus
#10
Hailiang Sun, Sherry Blackmon, Guohua Yang, Kaitlyn Waters, Tao Li, Ratanaporn Tangwangvivat, Yifei Xu, Daniel Shyu, Feng Wen, Jim Cooley, Lucy Senter, Xiaoxu Lin, Richard Jarman, Larry Hanson, Richard Webby, Xiu-Feng Wan
No abstract text is available yet for this article.
April 15, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29558524/survival-of-viral-pathogens-in-animal-feed-ingredients-under-transboundary-shipping-models
#11
Scott A Dee, Fernando V Bauermann, Megan C Niederwerder, Aaron Singrey, Travis Clement, Marcelo de Lima, Craig Long, Gilbert Patterson, Maureen A Sheahan, Ana M M Stoian, Vlad Petrovan, Cassandra K Jones, Jon De Jong, Ju Ji, Gordon D Spronk, Luke Minion, Jane Christopher-Hennings, Jeff J Zimmerman, Raymond R R Rowland, Eric Nelson, Paul Sundberg, Diego G Diel
The goal of this study was to evaluate survival of important viral pathogens of livestock in animal feed ingredients imported daily into the United States under simulated transboundary conditions. Eleven viruses were selected based on global significance and impact to the livestock industry, including Foot and Mouth Disease Virus (FMDV), Classical Swine Fever Virus (CSFV), African Swine Fever Virus (ASFV), Influenza A Virus of Swine (IAV-S), Pseudorabies virus (PRV), Nipah Virus (NiV), Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), Swine Vesicular Disease Virus (SVDV), Vesicular Stomatitis Virus (VSV), Porcine Circovirus Type 2 (PCV2) and Vesicular Exanthema of Swine Virus (VESV)...
2018: PloS One
https://www.readbyqxmd.com/read/29556821/isolation-and-characterization-of-an-avian-origin-h3n8-canine-influenza-virus-from-a-dog-in-eastern-china
#12
Xueliang Cao, Xinbo Liu, Shiying Zheng, Lihua Xu, Haibo Wu, Jie Liu
Previous studies have shown that dogs are susceptible to influenza A viruses, and the close contact between dogs and humans poses a threat to public health. In 2015, a novel H3N8 influenza virus was isolated from a dog in eastern China. This strain was characterized by whole-genome sequencing with subsequent phylogenetic analysis and genetic comparison and found to be most closely related to avian influenza viruses co-circulating in China. It was able to replicate in mice without prior adaptation. The continued circulation of this novel H3N8 influenza virus in dogs could endanger other mammalian species...
March 20, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29556219/integrated-lung-and-tracheal-mrna-seq-and-mirna-seq-analysis-of-dogs-with-an-avian-like-h5n1-canine-influenza-virus-infection
#13
Cheng Fu, Jie Luo, Shaotang Ye, Ziguo Yuan, Shoujun Li
Avian-like H5N1 canine influenza virus (CIV) causes severe respiratory infections in dogs. However, the mechanism underlying H5N1 CIV infection in dogs is unknown. The present study aimed to identify differentially expressed miRNAs and mRNAs in the lungs and trachea in H5N1 CIV-infected dogs through a next-generation sequencing-based method. Eighteen 40-day-old beagles were inoculated intranasally with CIV, A/canine/01/Guangdong/2013 (H5N1) at a tissue culture infectious dose 50 (TCID50 ) of 106 , and lung and tracheal tissues were harvested at 3 and 7 d post-inoculation...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29521106/wogonin-a-flavonoid-isolated-from-scutellaria-baicalensis-has-anti-viral-activities-against-influenza-infection-via-modulation-of-ampk-pathways
#14
R-K Seong, J-A Kim, O S Shin
Wogonin, a flavonoid isolated from Scutellaria baicalensis, has attracted increasing scientific attention in recent years because of its potent anti-tumor activity. Its role during viral infection has largely been unexplored. Wogonin treatment effectively suppressed both influenza A and B virus replication in Madin-Darby Canine Kidney (MDCK) cells and human lung epithelial (A549) cells. In contrast, wogonin treatment following influenza A virus infection led to up-regulation of interferon (IFN)-induced antiviral signaling...
2018: Acta Virologica
https://www.readbyqxmd.com/read/29511200/comparison-of-the-virulence-and-transmissibility-of-canine-h3n2-influenza-viruses-and-characterization-of-their-canine-adaptation-factors
#15
In-Won Lee, Young-Il Kim, Gyo-Jin Lim, Hyeok-Il Kwon, Young-Jae Si, Su-Jin Park, Eun-Ha Kim, Se Mi Kim, Hiep Dinh Nguyen, Min-Suk Song, Young-Ki Choi
Recent canine influenza outbreaks have raised concerns about the generation of pathogenic variants that may pose a threat to public health. Here, we examine avian-like H3N2 canine influenza viruses (CIVs) isolated from 2009 to 2013 in South Korea from dogs. Phylogenetic analysis revealed that these viruses are closely related to strains previously isolated from dogs in Korea and China. However, molecular characterization demonstrated non-synonymous mutations between the canine viruses, particularly in the putative H3 antigenic sites, NA stalk regions, and in the internal genes of the 2012-2013 isolates compared with the 2009 isolate...
March 7, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29498634/bax-inhibitor-1-acts-as-an-anti-influenza-factor-by-inhibiting-ros-mediated-cell-death-and-augmenting-heme-oxygenase-1-expression-in-influenza-virus-infected-cells
#16
Mohammed Kawser Hossain, Subbroto Kumar Saha, Ahmed Abdal Dayem, Jung-Hyun Kim, Kyeongseok Kim, Gwang-Mo Yang, Hye Yeon Choi, Ssang-Goo Cho
Influenza virus remains a major health concern worldwide, and there have been continuous efforts to develop effective antivirals despite the use of annual vaccination programs. The purpose of this study was to determine the anti-influenza activity of Bax inhibitor-1 ( BI-1 ). Madin-Darby Canine Kidney (MDCK) cells expressing wild type BI-1 and a non-functional BI-1 mutant, BI-1 ∆C (with the C-terminal 14 amino acids deleted) were prepared and infected with A/PR/8/34 influenza virus. BI-1 overexpression led to the suppression of virus-induced cell death and virus production compared to control Mock or BI-1 ∆C overexpression...
March 2, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29496100/pilot-study-of-the-financial-and-practice-protocol-impacts-of-canine-influenza-virus-h3n2-outbreaks-in-example-veterinary-practices
#17
Kennedy Mwacalimba, Annette Litster
Since March 2015, canine influenza virus (CIV) H3N2 has caused widespread outbreaks in dogs across the USA. The effects of local H3N2 outbreaks on veterinary practices were investigated using an online interface and followed with phone calls to respondents when necessary. An outbreak was defined as confirmed diagnosis of H3N2 by either PCR or serology in at least four dogs. Of 30 practices invited to participate, five met the entry criteria: at least one documented H3N2 outbreak in the previous 12 months, a predominantly (≥70%) small animal caseload, and adequate financial records to complete the survey...
March 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29493493/an-i436n-substitution-confers-resistance-of-influenza-a-h1n1-pdm09-viruses-to-multiple-neuraminidase-inhibitors-without-affecting-viral-fitness
#18
Jin Jung Kwon, Won-Suk Choi, Ju Hwan Jeong, Eun-Ha Kim, Ok-Jun Lee, Sun-Woo Yoon, Jungwon Hwang, Richard J Webby, Elena A Govorkova, Young Ki Choi, Yun Hee Baek, Min-Suk Song
The resistance of influenza viruses to neuraminidase (NA) inhibitors (NAIs; i.e. oseltamivir, zanamivir, peramivir and laninamivir) can be associated with several NA substitutions, with differing effects on viral fitness. To identify novel molecular markers conferring multi-NAI resistance, the NA gene of oseltamivir-resistant (H275Y, N1 numbering) 2009 pandemic influenza [A(H1N1)pdm09] virus was enriched with random mutations. This randomly mutated viral library was propagated in Madin-Darby canine kidney (MDCK) cells under zanamivir pressure and gave rise to additional changes within NA, including an I436N substitution located outside the NA enzyme active site...
March 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29493374/in-vitro-immunomodulatory-activity-of-celastrol-against-influenza-a-virus-infection
#19
Niloofar Khalili, Ali Karimi, Mohammad-Taghi Moradi, Hedayatollah Shirzad
CONTEXT: The influenza A virus (IAV) causes severe respiratory disease that remains a leading reason for morbidity and mortality. Previous studies have indicated that influenza complications in addition to viral replication are due to overproduction of pro-inflammatory cytokines. Therefore, a new compound is needed to be used with current antiviral drugs to modulate overproduction of pro-inflammatory cytokines in IAV infection. OBJECTIVE: This study investigated the effect of celastrol on mRNA expression and concentration levels of the pro-inflammatory cytokines tumor necrosis factor alpha (TNFα) and interleukin-6 (IL6) that are induced by influenza A/Puerto Rico/8/34 (H1N1; PR8) in Madin-Darby Canine Kidney (MDCK) cells...
March 1, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29448067/antiviral-resistance-due-to-deletion-in-the-neuraminidase-gene-and-defective-interfering-like-viral-polymerase-basic-2-rna-of-influenza-a-virus-subtype-h3n2
#20
Ramona Trebbien, Claus Bohn Christiansen, Thea Kølsen Fischer
BACKGROUND AND OBJECTIVE: Antiviral treatment of influenza virus infections can lead to drug resistance of virus. This study investigates a selection of mutations in the full genome of H3N2 influenza A virus isolated from a patient in treatment with oseltamivir. STUDY DESIGN: Respiratory samples from a patient were collected before, during, and after antiviral treatment. Whole genome sequencing of the influenza virus by next generation sequencing, and low-frequency-variant analysis was performed...
May 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
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