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Canine Influenza

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https://www.readbyqxmd.com/read/28532402/antiviral-activity-of-phenanthrenes-from-the-medicinal-plant-bletilla-striata-against-influenza-a-virus
#1
Ya Shi, Bing Zhang, Yiyu Lu, Chaodong Qian, Yan Feng, Liwei Fang, Zhishan Ding, Dongqing Cheng
BACKGROUND: Influenza represents a serious public health concern. The emergence of resistance to anti-influenza drugs underlines the need to develop new drugs. This study aimed to evaluate the anti-influenza viral activity and possible mechanisms of 12 phenanthrenes from the medicinal plant Bletilla striata (Orchidaceae family). METHODS: Twelve phenanthrenes were isolated and identified from B. striata. Influenza virus A/Sydney/5/97 (H3N2) propagated in embryonated chicken eggs was used...
May 22, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28521605/chemoenzymatic-synthesis-and-characterization-of-n-glycolylneuraminic-acid-carrying-sialoglycopolypeptides-as-effective-inhibitors-against-equine-influenza-virus-hemagglutination
#2
Makoto Ogata, Ami Koizumi, Tadamune Otsubo, Kiyoshi Ikeda, Mao Sakamoto, Rena Aita, Tatsuya Kato, Enoch Y Park, Takashi Yamanaka, Kazuya I P J Hidari
A series of novel sialoglycopolypeptides carrying N-glycolylneuraminic acid (Neu5Gc)-containing trisaccharides having α(2 → 3)- and α(2 → 6)-linkages in the side chains of γ-polyglutamic acid (γ-PGA) were designed as competitive inhibitors against equine influenza viruses (EIV), which critically recognize the Neu5Gc residue for receptor binding. Using horse red blood cells (HRBC) we successfully evaluated the binding activity of the multivalent Neu5Gc ligands to both equine and canine influenza viruses in the hemagglutination inhibition (HI) assay...
May 18, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28504013/anti-influenza-effect-of-the-major-flavonoids-from-salvia-plebeia-r-br-via-inhibition-of-influenza-h1n1-virus-neuraminidase
#3
Sunghee Bang, Wei Li, Thi Kim Quy Ha, Changyeol Lee, Won Keun Oh, Sang Hee Shim
To determine the compounds responsible for its anti-influenza activities, we isolated the three flavonoids, 6-hydroxyluteolin 7-O-β-d-glucoside (1), nepitrin (2), homoplantaginin (3) from the MeOH extract of Salvia plebeia R.Br. and identified them by comparing the spectroscopic data with that reported in the literature. The contents of the three flavonoids in the whole extract were 108.74 ± 0.95, 46.26 ± 2.19, and 69.35 ± 1.22 mg/g for 6-hydroxyluteolin 7-O-β-d-glucoside, nepitrin, and homoplantaginin, respectively, which demonstrates that they are the major constituents of this plant...
May 15, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28498621/enhanced-production-of-enveloped-viruses-in-bst-2-deficient-cell-lines
#4
Eunbi Yi, Jinsoo Oh, Ngoc Quynh Giao, Soohwan Oh, Se-Ho Park
Despite all the advantages that cell-cultured influenza vaccines have over egg-based influenza vaccines, the inferior productivity of cell-culture systems is a major drawback that must be addressed. BST-2 (tetherin) is a host restriction factor which inhibits budding-out of various enveloped viruses from infected host cells. We developed BST-2-deficient MDCK and Vero cell lines to increase influenza virus release in cell culture. BST-2 gene knock-out resulted in increased release of viral particles into the culture medium, by at least 2-fold and up to 50-fold compared to release from wild-type counterpart cells depending on cell line and virus type...
May 12, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28497210/genetic-characterization-of-influenza-a-h1n1-pandemic-2009-virus-isolates-from-mumbai
#5
Devanshi Gohil, Sweta Kothari, Pramod Shinde, Rhuta Meharunkar, Rajas Warke, Abhay Chowdhary, Ranjana Deshmukh
Pandemic influenza A (H1N1) 2009 virus was first detected in India in May 2009 which subsequently became endemic in many parts of the country. Influenza A viruses have the ability to evade the immune response through its ability of antigenic variations. The study aims to characterize influenza A (H1N1) pdm 09 viruses circulating in Mumbai during the pandemic and post-pandemic period. Nasopharyngeal swabs positive for influenza A (H1N1) pdm 09 viruses were inoculated on Madin-Darby canine kidney cell line for virus isolation...
May 11, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28492063/vaccination-with-killed-but-metabolically-active-e-coli-over-expressing-hemagglutinin-elicits-neutralizing-antibodies-to-h1n1-swine-origin-influenza-a-virus
#6
Pei-Feng Liu, Yanhan Wang, Yu-Tsueng Liu, Chun-Ming Huang
There is a need for a fast and simple method for vaccine production to keep up with the pace of a rapidly spreading virus in the early phases of the influenza pandemic. The use of whole viruses produced in chicken eggs or recombinant antigens purified from various expression systems has presented considerable challenges, especially with lengthy processing times. Here, we use the killed but metabolically active (KBMA) Escherichia coli (E. coli) to harbor the hemagglutinin (HA) of swine origin influenza A (H1N1) virus (S-OIV) San Diego/01/09 (SD/H1N1-S-OIV)...
February 2017: Journal of Nature and Science
https://www.readbyqxmd.com/read/28484702/expression-dynamics-of-innate-immunity-in-influenza-virus-infected-swine
#7
María Montoya, Emanuela Foni, Alicia Solórzano, Elisabetta Razzuoli, Massimiliano Baratelli, Dania Bilato, Lorena Córdoba, Maria Angeles Martín Del Burgo, Jorge Martinez, Pamela Martinez-Orellana, Chiara Chiapponi, David S Perlin, Gustavo Del Real, Massimo Amadori
The current circulating swine influenza virus (IV) subtypes in Europe (H1N1, H1N2, and H3N2) are associated with clinical outbreaks of disease. However, we showed that pigs could be susceptible to other IV strains that are able to cross the species barrier. In this work, we extended our investigations into whether different IV strains able to cross the species barrier might give rise to different innate immune responses that could be associated with pathological lesions. For this purpose, we used the same samples collected in a previous study of ours, in which healthy pigs had been infected with a H3N2 Swine IV and four different H3N8 IV strains circulating in different animal species...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28438112/h3n2-canine-influenza-virus-infection-in-a-dog
#8
C E Watson, C Bell, K Toohey-Kurth
In 2015, H3N2 canine influenza emerged in dogs in the greater Chicago area. During this time, a 10-year-old German Shepherd dog presented to the referring veterinarian with lethargy and coughing that quickly progressed to death. This report describes the macroscopic and microscopic lesions and the molecular testing performed to identify the novel North American H3N2 strain of canine influenza. The larynx, pharynx, and trachea were covered by a fibrinonecrotic membrane. Bilaterally, the lungs had multifocal subpleural necrosis of the caudal lung lobes with hemorrhage, congestion, and pulmonary edema...
May 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28416546/anti-influenza-activity-of-bacillus-subtilis-probiotic-strain
#9
Darya Starosila, Svetlana Rybalko, Ludmila Varbanetz, Naila Ivanskaya, Iryna Sorokulova
Among Bacillus bacteria, B. subtilis is the most productive species of antimicrobial compounds. In this study, we analyzed the activity of probiotic strain B. subtilis 3 against influenza virus. The antiviral effect of this strain has been demonstrated in vitro and in vivo New peptide P18 produced by probiotic strain was isolated, purified, chemically synthesized, and characterized. Cytotoxicity studies demonstrated no toxic effect of P18 on Madin-Darby canine kidney (MDCK) cells, even in the highest tested concentration (100 μg/mL)...
April 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28400751/ethanolic-extract-of-melia-fructus-has-anti-influenza-a-virus-activity-by-affecting-viral-entry-and-viral-rna-polymerase
#10
Young-Hee Jin, Jang-Gi Choi, Won-Kyung Cho, Jin Yeul Ma
Meliae Fructus (MF) is the dried ripe fruit of Melia toosendan Siebold et Zuccarini, Meliaceae family. MF is widely used in traditional medicine to treat inflammation and helminthic infection and has anti-bacterial, anti-oxidant, anti-cancer, anti-inflammatory, and analgesic activities. However, potential anti-influenza properties of MF have yet to be investigated. We determined whether an ethanolic extract of MF (EMF) has anti-viral activity via an EMF pre-, co-, and post-treatment assay, using the Influenza A/PR/8/34 and H3N2 virus on Madin-Darby canine kidney (MDCK) cells...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28399176/pathological-findings-in-the-red-fox-vulpes-vulpes-stone-marten-martes-foina-and-raccoon-dog-nyctereutes-procyonoides-with-special-emphasis-on-infectious-and-zoonotic-agents-in-northern-germany
#11
Charlotte Lempp, Nicole Jungwirth, Miguel L Grilo, Anja Reckendorf, Arlena Ulrich, Abbo van Neer, Rogier Bodewes, Vanessa M Pfankuche, Christian Bauer, Albert D M E Osterhaus, Wolfgang Baumgärtner, Ursula Siebert
Anthropogenic landscape changes contributed to the reduction of availability of habitats to wild animals. Hence, the presence of wild terrestrial carnivores in urban and peri-urban sites has increased considerably over the years implying an increased risk of interspecies spillover of infectious diseases and the transmission of zoonoses. The present study provides a detailed characterisation of the health status of the red fox (Vulpes vulpes), stone marten (Martes foina) and raccoon dog (Nyctereutes procyonoides) in their natural rural and peri-urban habitats in Schleswig-Holstein, Germany between November 2013 and January 2016 with focus on zoonoses and infectious diseases that are potentially threatening to other wildlife or domestic animal species...
2017: PloS One
https://www.readbyqxmd.com/read/28385007/experimental-infection-of-dogs-with-highly-pathogenic-avian-influenza-virus-h5n8
#12
Seong-Su Yuk, Dong-Hun Lee, Jae-Keun Park, Eredene-Ochir To, Jung-Hoon Kwon, Jin-Yong Noh, Chang-Seon Song
During the highly pathogenic avian influenza (HPAI) H5N8 outbreak in South Korea, a dog reared in layer farm contaminated by the virus was reported seropositive for HPAI H5N8. In order to investigate the possibility of the adaptation and transmission of HPAI H5N8 to dogs, we inoculated the H5N8 to dogs in experimental condition. Weak viral genes in nasal swabs and seroconversions were detected even in contact dogs. Although the H5N8 virus doesn't seem to adapt to canine species fully, these results suggest that surveillance on farm dogs should continue as a species in which avian influenza virus may acquire infectivity to mammals through frequent contact with the virus...
April 6, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28282885/anti-influenza-virus-h5n1-activity-screening-on-the-phloroglucinols-from-rhizomes-of-dryopteris-crassirhizoma
#13
Juan Wang, Yan-Tao Yan, Shen-Zhen Fu, Bing Peng, Lin-Lin Bao, Yan-Ling Zhang, Jing-Hong Hu, Zu-Ping Zeng, Dong-Hao Geng, Zeng-Ping Gao
For screening the active phloroglucinols on influenza virus (H5N1) from Dryopteris crassirhizoma NaKai, a database was established including twenty-three phloroglucinols that had been isolated from Dryopteris crassirhizoma. Their inhibitory effect on the neuraminidase (NA) of influenza virus H5N1 was screened by molecular docking. As a result, three candidates were selected. The rhizomes of D. crassirhizoma were subjected to isolation and purification processes to obtain the inhibitor candidates. Thirteen phloroglucinols were obtained, including three selected candidates and two new phloroglucinols...
March 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28272019/geniposide-demonstrates-anti-inflammatory-and-antiviral-activity-against-pandemic-a-jiangsu-1-2009-h1n1-influenza-virus-infection-in-vitro-and-in-vivo
#14
Zhang Yunshi, Yao Jing, Qi Xian, Liu Xing, Lu Xieqin, Feng Ganzhu
BACKGROUND: Influenza A viruses (IAVs) remains to be a great threat to human health for centuries, without effective control. Geniposide, a main iridoid glycoside compound extracted from Gardenia jasminoides Ellis (GJ) fruit, possesses various biologic activities including anti-inflammation and anti-virus. METHODS: Madin-Darby Canine Kidney (MDCK) cells were infected with pandemic A/Jiangsu/1/2009 (H1N1) influenza virus in vitro. Cytotoxicity and antiviral activity of geniposide were estimated by MTT assay...
March 8, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28271163/molecular-characterization-of-neuraminidase-genes-of-influenza-a-h3n2-viruses-circulating-in-southwest-india-from-2009-to-2013
#15
Anitha Jagadesh, Abdul Ajees Abdul Salam, Vahid Rajabali Zadeh, Anjana Krishnan, Govindakarnavar Arunkumar
Molecular characterization of neuraminidase (NA) gene of 25 influenza A(H3N2) virus isolates (2009-2013) archived at the Manipal Centre for Virus Research was carried out. The annual rate of amino acid substitutions in the N2 gene of influenza A(H3N2) virus isolates was 0.2-0.6%. Out of the 25 NA sequences analyzed, catalytic site mutations were observed in three isolates. Two of the mutations (D151G and E276G) were detected in functional catalytic residues, and an E227V mutation was detected in the framework residues...
March 7, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28237237/expanding-veterinary-biosurveillance-in-washington-dc-the-creation-and-utilization-of-an-electronic-based-online-veterinary-surveillance-system
#16
Andrew Hennenfent, Vito DelVento, John Davies-Cole, Fern Johnson-Clarke
OBJECTIVES: To enhance the early detection of emerging infectious diseases and bioterrorism events using companion animal-based surveillance. METHODS: Washington, DC, small animal veterinary facilities (n=17) were surveyed to determine interest in conducting infectious disease surveillance. Using these results, an electronic-based online reporting system was developed and launched in August 2015 to monitor rates of canine influenza, canine leptospirosis, antibiotic resistant infections, canine parvovirus, and syndromic disease trends...
March 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28207898/distinct-susceptibility-and-applicability-of-mdck-derivatives-for-influenza-virus-research
#17
Shih-Chao Lin, Matthew A Kappes, Mei-Chun Chen, Chi-Chen Lin, Tony T Wang
Madin-Darby Canine Kidney (MDCK) cells are widely utilized as a substrate for influenza virus isolation and propagation due to the high yields of virus. Here we compared the conventional MDCK cell line, MDCK-SIAT1 and MDCK-London for viral production, cell survival, and suitability in testing antivirals using six influenza strains including two H1N1 (pandemic and epidemic strains), three H3N2 and one influenza B strain. Overall our results suggest that MDCK-London cell line is superior for virus culturing and quantification, and hence an ideal platform to evaluate antiviral drug efficacy against multiple strains of influenza...
2017: PloS One
https://www.readbyqxmd.com/read/28173854/anti-influenza-virus-activity-of-extracts-from-the-stems-of-jatropha-multifida-linn-collected-in-myanmar
#18
Masaki Shoji, So-Yeun Woo, Aki Masuda, Nwet Nwet Win, Hla Ngwe, Etsuhisa Takahashi, Hiroshi Kido, Hiroyuki Morita, Takuya Ito, Takashi Kuzuhara
BACKGROUND: To contribute to the development of novel anti-influenza drugs, we investigated the anti-influenza activity of crude extracts from 118 medicinal plants collected in Myanmar. We discovered that extract from the stems of Jatropha multifida Linn. showed anti-influenza activity. J. multifida has been used in traditional medicine for the treatment of various diseases, and the stem has been reported to possess antimicrobial, antimalarial, and antitumor activities. However, the anti-influenza activity of this extract has not yet been investigated...
February 7, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28167384/a-live-attenuated-influenza-vaccine-for-h3n2-canine-influenza-virus
#19
Laura Rodriguez, Aitor Nogales, Emma C Reilly, David J Topham, Pablo R Murcia, Colin R Parrish, Luis Martinez Sobrido
Canine influenza is a contagious respiratory disease in dogs caused by two subtypes (H3N2 and H3N8) of canine influenza virus (CIV). Currently, only inactivated influenza vaccines (IIVs) are available for the prevention of CIVs. Historically, live-attenuated influenza vaccines (LAIVs) have been shown to produce better immunogenicity and protection efficacy than IIVs. Here, we have engineered a CIV H3N2 LAIV by using the internal genes of a previously described CIV H3N8 LAIV as a master donor virus (MDV) and the surface HA and NA genes of a circulating CIV H3N2 strain...
April 2017: Virology
https://www.readbyqxmd.com/read/28161578/consensus-m2e-peptide-conjugated-to-gold-nanoparticles-confers-protection-against-h1n1-h3n2-and-h5n1-influenza-a-viruses
#20
Wenqian Tao, Brett L Hurst, Akhilesh Kumar Shakya, Md Jasim Uddin, Rohan S J Ingrole, Mayra Hernandez-Sanabria, Ravi P Arya, Lynn Bimler, Silke Paust, E Bart Tarbet, Harvinder Singh Gill
The extracellular domain of influenza A ion channel membrane matrix protein 2 (M2e) is considered to be a potential candidate to develop a universal influenza A vaccine. However poor immunogenicity of M2e presents a significant roadblock. We have developed a vaccine formulation comprising of the consensus M2e peptide conjugated to gold nanoparticles (AuNPs) with CpG as a soluble adjuvant (AuNP-M2e + sCpG). We demonstrate that intranasal delivery of AuNP-M2e + sCpG in mice induces lung B cell activation and robust serum anti-M2e immunoglobulin G (IgG) response, with stimulation of both IgG1 and IgG2a subtypes...
May 2017: Antiviral Research
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