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Canine Influenza

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https://www.readbyqxmd.com/read/28859269/optimized-clade-2-3-2-1c-h5n1-recombinant-vaccine-strains-against-highly-pathogenic-avian-influenza
#1
Jin-Wook Jang, Chung-Young Lee, Il-Hwan Kim, Jun-Gu Choi, Youn-Jeong Lee, Seong-Su Yuk, Ji-Ho Lee, Chang-Seon Song, Jae-Hong Kim, Hyuk-Joon Kwon
A/Puerto Rico/8/34 (PR8)-derived recombinant viruses have been used for seasonal flu vaccines; however, they are insufficient for vaccines against some human-fatal H5N1 highly pathogenic avian influenza (HPAI) viruses (HPAIV) due to low productivity. Additionally, the polymerase basic 2 (PB2) protein, an important mammalian-pathogenicity determinant, of PR8 possesses several mammalian-pathogenic mutations. We previously reported two avian PB2 genes (01310 and 0028) related to efficient replication in embryonated chicken eggs (ECEs) and nonpathogenicity in BALB/c mice...
August 31, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28858604/spread-of-canine-influenza-a-h3n2-virus-united-states
#2
Ian E H Voorhees, Amy L Glaser, Kathy Toohey-Kurth, Sandra Newbury, Benjamin D Dalziel, Edward J Dubovi, Keith Poulsen, Christian Leutenegger, Katriina J E Willgert, Laura Brisbane-Cohen, Jill Richardson-Lopez, Edward C Holmes, Colin R Parrish
A canine influenza A(H3N2) virus emerged in the United States in February-March 2015, causing respiratory disease in dogs. The virus had previously been circulating among dogs in Asia, where it originated through the transfer of an avian-origin influenza virus around 2005 and continues to circulate. Sequence analysis suggests the US outbreak was initiated by a single introduction, in Chicago, of an H3N2 canine influenza virus circulating among dogs in South Korea in 2015. Despite local control measures, the virus has continued circulating among dogs in and around Chicago and has spread to several other areas of the country, particularly Georgia and North Carolina, although these secondary outbreaks appear to have ended within a few months...
December 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28835506/amino-acid-substitution-k186e-in-the-canine-influenza-virus-h3n8-ns1-protein-restores-its-ability-to-inhibit-host-gene-expression
#3
Aitor Nogales, Caroline Chauché, Marta L DeDiego, David J Topham, Colin R Parrish, Pablo R Murcia, Luis Martínez-Sobrido
Canine influenza viruses (CIVs) are the causative agents of canine influenza, a contagious respiratory disease in dogs, and include the equine-origin H3N8 and the avian-origin H3N2. Influenza A virus (IAV) non-structural protein 1 (NS1) is a virulence factor essential for counteracting the innate immune response. Here, we evaluated the ability of H3N8 CIV NS1 to inhibit host innate immune responses. We found that H3N8 CIV NS1 was able to efficiently counteract interferon (IFN) responses but was unable to block general gene expression in human or canine cells...
August 23, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28814512/zoonotic-risk-pathogenesis-and-transmission-of-avian-origin-h3n2-canine-influenza-virus
#4
Hailiang Sun, Sherry Blackmon, Guohua Yang, Kaitlyn Waters, Tao Li, Ratanaporn Tangwangvivat, Yifei Xu, Daniel Shyu, Feng Wen, Jim Cooley, Lucy Senter, Xiaoxu Lin, Richard Jarman, Larry Hanson, Richard Webby, Xiu-Feng Wan
Two subtypes of influenza A virus (IAV), avian-origin canine influenza virus H3N2 (CIV-H3N2) and equine-origin CIV-H3N8, are enzootic in the canine population. Dogs have demonstrated seroconversion to diverse IAVs and naturally occurring reassortants of CIV-H3N2 and the 2009 H1N1 pandemic virus (pdmH1N1) have been isolated. We conducted a thorough phenotypic evaluation of CIV-H3N2 in order to assess its threat to human health. Using ferret-generated antisera we determined that CIV-H3N2 is antigenically distinct from contemporary human H3N2 IAVs, suggesting there may be minimal herd immunity in humans...
August 16, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28777309/biological-evaluation-of-uridine-derivatives-of-2-deoxy-sugars-as-potential-antiviral-compounds-against-influenza-a-virus
#5
Ewelina Krol, Ilona Wandzik, Martyna Krejmer-Rabalska, Boguslaw Szewczyk
Influenza virus infection is a major cause of morbidity and mortality worldwide. Due to the limited ability of currently available treatments, there is an urgent need for new anti-influenza drugs with broad spectrum protection. We have previously shown that two 2-deoxy sugar derivatives of uridine (designated IW3 and IW7) targeting the glycan processing steps during maturation of viral glycoproteins show good anti-influenza virus activity and may be a promising alternative approach for the development of new anti-influenza therapy...
August 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28757141/molecular-epidemiology-of-a-novel-re-assorted-epidemic-strain-of-equine-influenza-virus-in-pakistan-in-2015-16
#6
Amjad Khan, Muhammad Hassan Mushtaq, Mansur Ud Din Ahmad, Jawad Nazir, Shahid Hussain Farooqi, Asghar Khan
BACKGROUND: A widespread epidemic of equine influenza (EI) occurred in nonvaccinated equine population across multiple districts in Khyber Pakhtunkhwa Province of Pakistan during 2015-2016. OBJECTIVES AND METHODS: An epidemiological surveillance study was conducted from Oct 2015 to April 2016 to investigate the outbreak. EI virus strains were isolated in embryonated eggs from suspected equines swab samples and were subjected to genome sequencing using M13 tagged segment specific primers...
July 27, 2017: Virus Research
https://www.readbyqxmd.com/read/28751224/molecular-cloning-and-functional-characterization-of-eleven-subtypes-of-interferon-%C3%AE-in-amur-tigers-panthera-tigris-altaica
#7
Hongjing Zhao, Jian Ma, Yu Wang, Juanjuan Liu, Yizhi Shao, Jinglun Li, Guangshun Jiang, Mingwei Xing
Interferon has a broad-spectrum of antiviral effects and represents an ideal choice for the development of antiviral drugs. Nonetheless, information about alpha interferon (IFN-α) is vacant in Amur tiger (Panthera tigris altaica), an endangered species and indigenous to northeast Asia. Herein, 11 PtIFN-αs genes, which encoded proteins of 164-165 amino acids, were amplified. Afterwards, expression and purification were conducted in Escherichia coli. In physicochemical analysis, PtIFN-αs were shown to be highly sensitive to trypsin and remained stable despite changes in pH and temperature...
July 24, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28714491/molecular-epidemiology-and-antigenic-characterization-of-seasonal-influenza-viruses-circulating-in-nepal
#8
B P Upadhyay, P Ghimire, M Tashiro, M R Banjara
BACKGROUND: Influenza is one of the public health burdens in Nepal and its epidemiology is not clearly understood. The objective of this study was to explore the molecular epidemiology and the antigenic characteristics of the circulating influenza viruses in Nepal. METHODS: A total of 1495 throat swab specimens were collected from January to December, 2014. Real time PCR assay was used for identification of influenza virus types and subtypes. Ten percent of the positive specimens were randomly selected and inoculated onto Madin-Darby Canine Kidney Epithelial cells (MDCK) for influenza virus isolation...
January 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28709557/a-bivalent-live-attenuated-influenza-vaccine-for-the-control-and-prevention-of-h3n8-and-h3n2-canine-influenza-viruses
#9
Laura Rodriguez, Aitor Nogales, Pablo R Murcia, Colin R Parrish, Luis Martínez-Sobrido
Canine influenza viruses (CIVs) cause a contagious respiratory disease in dogs. CIV subtypes include H3N8, which originated from the transfer of H3N8 equine influenza virus (EIV) to dogs; and the H3N2, which is an avian-origin virus adapted to infect dogs. Only inactivated influenza vaccines (IIVs) are currently available against the different CIV subtypes. However, the efficacy of these CIV IIVs is not optimal and improved vaccines are necessary for the efficient prevention of disease caused by CIVs in dogs...
July 11, 2017: Vaccine
https://www.readbyqxmd.com/read/28685290/suspension-culture-process-for-h9n2-avian-influenza-virus-strain-re-2
#10
Honglin Wang, Suying Guo, Zhenguang Li, Xiaoqin Xu, Zexiang Shao, Guicai Song
H9N2 avian influenza virus has caused huge economic loss for the Chinese poultry industry since it was first identified. Vaccination is frequently used as a control method for the disease. Meanwhile suspension culture has become an important tool for the development of influenza vaccines. To optimize the suspension culture conditions for the avian influenza H9N2 virus (Re-2 strain) in Madin-Darby Canine Kidney (MDCK) cells, we studied the culture conditions for cell growth and proliferation parameters for H9N2 virus replication...
July 7, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28674259/pinanamine-is-a-promising-lead-compound-against-influenza-a-virus-evidence-from-in-vitro-and-in-vivo-efficacy-compared-to-amantadine
#11
Runfeng Li, Chunguang Yang, Qiuling Du, Xin Zhao, Haiming Jiang, Wenhui Hu, Zifeng Yang
Influenza A viruses with the presence of mutations in M2 still circulate and threaten to avian species and human in China. A novel M2 inhibitor pinanamine was previously identified as an antiviral agent by an in vitro assay. In this study, we monitored the activity of pinanamine against influenza A/FM1/47 (H1N1) virus infection in cell culture and mice. Pinanamine showed more potent antiviral effect than ribavirin, and was as effective as oseltamivir carboxylate and amantadine in Madin-Darby canine kidney (MDCK) cells...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28668573/safety-and-immunogenicity-of-an-inactivated-cell-culture-derived-h7n9-influenza-vaccine-in-healthy-adults-a-phase-i-ii-prospective-randomized-open-label-trial
#12
Un-In Wu, Szu-Min Hsieh, Wen-Sen Lee, Ning-Chi Wang, Hsiang-Chi Kung, Tsong-Yih Ou, Fu-Lun Chen, Te-Yu Lin, Yee-Chun Chen, Shan-Chwen Chang
BACKGROUND: We conducted a phase I/II clinical trial to evaluate the safety and immunogenicity of a Madin-Darby canine kidney (MDCK) cell-grown inactivated H7N9 influenza vaccine for pandemic preparedness purposes. METHODS: Between April 7, 2015 and May 27, 2016, healthy adults aged 20-60years were enrolled sequentially in phase I (n=40) and phase II (n=160) from three hospitals in Taiwan and randomized to receive 2 doses of whole-virus H7N9 vaccine (15 or 30μg hemagglutinin antigen (HA) with or without an aluminum hydroxide adjuvant) at 21-day intervals...
June 28, 2017: Vaccine
https://www.readbyqxmd.com/read/28635524/serology-and-protein-electrophoresis-for-evidence-of-exposure-to-12-mink-pathogens-in-free-ranging-american-mink-neovison-vison-in-argentina
#13
Pablo Eduardo Martino, Luis Ernesto Samartino, Néstor Oscar Stanchi, Nilda Esther Radman, Eduardo Joaquín Parrado
BACKGROUND: Basic pathologic characteristics for farmed minks were previously reported worldwide. However, its status in the wild has not been studied in detail. OBJECTIVE: Serology and electrophoresis were carried out for evidence of exposure to 12 mink pathogens on two different locations. ANIMALS AND METHODS: Serology was done in 87 wild minks by reference techniques against Toxoplasma gondii, Encephalitozoon cuniculi, Neospora caninum, Brucella abortus, Mycobacterium bovis, Leptospira interrogans, canine distemper virus (CDV), canine adenovirus (CAV), canine parvovirus (CPV), rabies virus (RV), Influenza A virus (FLUAV) and Aleutian disease virus (ADV)...
December 2017: Veterinary Quarterly
https://www.readbyqxmd.com/read/28629724/in%C3%A2-vitro-antiviral-effects-of-peganum-harmala-seed-extract-and-its-total-alkaloids-against-influenza-virus
#14
Mohammad-Taghi Moradi, Ali Karimi, Mahmoud Rafieian-Kopaei, Fatemeh Fotouhi
This research was aimed to evaluate the in vitro antiviral effect and the mechanism of the effect of Peganum. harmala seeds extract against influenza A virus infection using Madin-Darby canine kidney (MDCK) cells. In this research, ethyl alcohol extract of P. harmala seeds and its total alkaloids was prepared. The potential antiviral activity of the extract and its total alkaloids against influenza A/Puerto Rico/8/34 (H1N1; PR8) virus was assessed. The mode of action of the extract to inhibit influenza replication was investigated using virucidal activity, hemagglutination inhibition assay, time of addition assays, RNA replication, western blot analysis and RNA polymerase blocking assay...
June 16, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28532402/antiviral-activity-of-phenanthrenes-from-the-medicinal-plant-bletilla-striata-against-influenza-a-virus
#15
Ya Shi, Bing Zhang, Yiyu Lu, Chaodong Qian, Yan Feng, Liwei Fang, Zhishan Ding, Dongqing Cheng
BACKGROUND: Influenza represents a serious public health concern. The emergence of resistance to anti-influenza drugs underlines the need to develop new drugs. This study aimed to evaluate the anti-influenza viral activity and possible mechanisms of 12 phenanthrenes from the medicinal plant Bletilla striata (Orchidaceae family). METHODS: Twelve phenanthrenes were isolated and identified from B. striata. Influenza virus A/Sydney/5/97 (H3N2) propagated in embryonated chicken eggs was used...
May 22, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28521605/chemoenzymatic-synthesis-and-characterization-of-n-glycolylneuraminic-acid-carrying-sialoglycopolypeptides-as-effective-inhibitors-against-equine-influenza-virus-hemagglutination
#16
Makoto Ogata, Ami Koizumi, Tadamune Otsubo, Kiyoshi Ikeda, Mao Sakamoto, Rena Aita, Tatsuya Kato, Enoch Y Park, Takashi Yamanaka, Kazuya I P J Hidari
A series of novel sialoglycopolypeptides carrying N-glycolylneuraminic acid (Neu5Gc)-containing trisaccharides having α(2 → 3)- and α(2 → 6)-linkages in the side chains of γ-polyglutamic acid (γ-PGA) were designed as competitive inhibitors against equine influenza viruses (EIV), which critically recognize the Neu5Gc residue for receptor binding. Using horse red blood cells (HRBC) we successfully evaluated the binding activity of the multivalent Neu5Gc ligands to both equine and canine influenza viruses in the hemagglutination inhibition (HI) assay...
August 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28504013/anti-influenza-effect-of-the-major-flavonoids-from-salvia-plebeia-r-br-via-inhibition-of-influenza-h1n1-virus-neuraminidase
#17
Sunghee Bang, Wei Li, Thi Kim Quy Ha, Changyeol Lee, Won Keun Oh, Sang Hee Shim
To determine the compounds responsible for its anti-influenza activities, we isolated the three flavonoids, 6-hydroxyluteolin 7-O-β-d-glucoside (1), nepitrin (2), homoplantaginin (3) from the MeOH extract of Salvia plebeia R.Br. and identified them by comparing the spectroscopic data with that reported in the literature. The contents of the three flavonoids in the whole extract were 108.74 ± 0.95, 46.26 ± 2.19, and 69.35 ± 1.22 mg/g for 6-hydroxyluteolin 7-O-β-d-glucoside, nepitrin, and homoplantaginin, respectively, which demonstrates that they are the major constituents of this plant...
May 15, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28498621/enhanced-production-of-enveloped-viruses-in-bst-2-deficient-cell-lines
#18
Eunbi Yi, Jinsoo Oh, Ngoc Q Giao, Soohwan Oh, Se-Ho Park
Despite all the advantages that cell-cultured influenza vaccines have over egg-based influenza vaccines, the inferior productivity of cell-culture systems is a major drawback that must be addressed. BST-2 (tetherin) is a host restriction factor which inhibits budding-out of various enveloped viruses from infected host cells. We developed BST-2-deficient MDCK and Vero cell lines to increase influenza virus release in cell culture. BST-2 gene knock-out resulted in increased release of viral particles into the culture medium, by at least 2-fold and up to 50-fold compared to release from wild-type counterpart cells depending on cell line and virus type...
May 12, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28497210/genetic-characterization-of-influenza-a-h1n1-pandemic-2009-virus-isolates-from-mumbai
#19
Devanshi Gohil, Sweta Kothari, Pramod Shinde, Rhuta Meharunkar, Rajas Warke, Abhay Chowdhary, Ranjana Deshmukh
Pandemic influenza A (H1N1) 2009 virus was first detected in India in May 2009 which subsequently became endemic in many parts of the country. Influenza A viruses have the ability to evade the immune response through its ability of antigenic variations. The study aims to characterize influenza A (H1N1) pdm 09 viruses circulating in Mumbai during the pandemic and post-pandemic period. Nasopharyngeal swabs positive for influenza A (H1N1) pdm 09 viruses were inoculated on Madin-Darby canine kidney cell line for virus isolation...
May 11, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28492063/vaccination-with-killed-but-metabolically-active-e-coli-over-expressing-hemagglutinin-elicits-neutralizing-antibodies-to-h1n1-swine-origin-influenza-a-virus
#20
Pei-Feng Liu, Yanhan Wang, Yu-Tsueng Liu, Chun-Ming Huang
There is a need for a fast and simple method for vaccine production to keep up with the pace of a rapidly spreading virus in the early phases of the influenza pandemic. The use of whole viruses produced in chicken eggs or recombinant antigens purified from various expression systems has presented considerable challenges, especially with lengthy processing times. Here, we use the killed but metabolically active (KBMA) Escherichia coli (E. coli) to harbor the hemagglutinin (HA) of swine origin influenza A (H1N1) virus (S-OIV) San Diego/01/09 (SD/H1N1-S-OIV)...
February 2017: Journal of Nature and Science
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