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stress hcc

Bin Li, Guo-Liang Wu, Wei Dai, Gang Wang, Hao-Yuan Su, Xue-Ping Shen, Rui Zhan, Jia-Ming Xie, Zhong Wang, Zheng-Hong Qin, Quan-Gen Gao, Gen-Hai Shen
Aescin, a natural mixture of triterpene saponins, has been reported to exert anticancer effect. Recent studies show that aescin increases intracellular reactive oxygen species (ROS) levels. However, whether the increased ROS play a role in the anticancer action of aescin remains to be explored. In this study, we demonstrated that aescin (20-80 μg/mL) dose-dependently induced apoptosis and activated mammalian target of rapamycin (mTOR)-independent autophagy in human hepatocellular carcinoma HepG2 cells and colon carcinoma HCT 116 cells...
June 19, 2018: Acta Pharmacologica Sinica
Xuan Zhang, Silin Zhang, Qitong Sun, Wenjun Jiao, Yan Yan, Xuewu Zhang
The ginsenoside compound K (20- O -β-d-glucopyranosyl-20( S )-protopanaxadiol; CK) is an intestinal bacterial metabolite of ginseng protopanaxadiol saponin that has been reported to induce apoptosis in many cancer cells; however, the precise mechanisms of its activity in human hepatocellular carcinoma (HCC) cells remain unclear. Herein, we demonstrated that CK inhibited the growth and colony formation of HepG2 and SMMC-7721 cells, phenotypes that were mediated by inducing apoptosis. Meanwhile, CK showed lower toxicity in normal hepatoma cells...
June 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Anke Köbach, Martina Ruf-Leuschner, Thomas Elbert
BACKGROUND: Anecdotal evidence suggests the frequently traumatic nature of female genital mutilation (FGM). At present, systematic research on the psychological sequelae of this tradition has remained limited. The study provides preliminary, high-quality psychodiagnostic data on potential psychopathological consequences of FGM, with a focus on posttraumatic stress disorder (PTSD), shutdown dissociation and other stress-related variables. METHODS: We investigated a convenience sample of N = 167 women, supported by the women's affairs headquarters in Jijiga (capital of the Ethiopian Somali Region) and a local Ethiopian non-governmental organization...
June 13, 2018: BMC Psychiatry
Ying Sun, Jiao Fang, Yuhui Wan, Jingjing Hu, Yuanyuan Xu, Fangbiao Tao
OBJECTIVE: To examine whether polygenic susceptibility for body mass index (BMI) interacts with cumulative stress exposure, potentially exacerbating and buffering the effects of chronic stress, to predict obesity during childhood. METHODS: Data were analyzed from an established prospective puberty cohort in Anhui province, China. A total of 1000 children (421 boys and 579 girls, mean (standard deviation) age 8.97 (0.86) years) who had complete DNA genotyping, hair cortisol concentration and BMI were eligible for the study...
June 11, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Zhikun Liu, Qianwei Ye, Lingjiao Wu, Feng Gao, Haiyang Xie, Lin Zhou, Shusen Zheng, Xiao Xu
Metallothionein 1 (MT1s) is a family of cysteine-rich proteins with diverse functions such as metal homeostasis, oxidative stress, and carcinogenesis. However, its involvement in hepatocellular carcinoma (HCC) remains not fully understood. We aimed to explore the contribution of the individual member of MT1s to HCC. Its member mRNA levels were determined in cohort 1 of normal (n = 30), cirrhotic (n = 30), peritumoral (n = 135), and HCC (n = 135). In cohort 1, seven of 8 members were down-regulated during the transition from normal liver to HCC, and only MT1G and MT1X were correlated with tumor features and outcomes...
June 6, 2018: Molecular Carcinogenesis
Mike Freya Müller, Timothy James Kendall, David James Adams, Ying Zhou, Mark Johan Arends
Disease progression in alcoholic and non-alcoholic fatty liver disease shows sex-specific differences and is influenced by mechanisms linked to oxidative stress. Acetaldehyde plays a critical pathogenic role but its effects are mitigated by the activity of aldehyde dehydrogenases. Aldehyde dehydrogenase 1b1 (Aldh1b1) is the aldehyde dehydrogenase isoform with the second highest affinity for acetaldehyde after Aldh2, and is highly expressed in the intestine and liver. We examined sex differences and the effect of Aldh1b1 depletion in a murine model of chronic alcohol-induced liver disease...
May 31, 2018: Experimental and Molecular Pathology
Arbace Officioso, Lucia Panzella, Fabiana Tortora, Maria Laura Alfieri, Alessandra Napolitano, Caterina Manna
Oxidative stress is one of the underlying mechanisms of the toxic effects exerted by mercury (Hg) on human health. Several antioxidant compounds, including the olive oil phenol hydroxytyrosol (HT), were investigated for their protective action. Recently, we have reported that 5- S -lipoylhydroxytyrosol (Lipo-HT) has shown increased antioxidant activities compared to HT and exerted potent protective effects against reactive oxygen species (ROS) generation and oxidative damage in human hepatocellular carcinoma HepG2 cell lines...
2018: Oxidative Medicine and Cellular Longevity
Ruyan Wan, Xiaohua Xia, Peijin Wang, Weiran Huo, Hui Dong, Zhongjie Chang
Ionic liquids have garnered increasing attention due to their capacity for low vapor pressure, lack of flammability, designability, good stability, and as a asubstitute for conventional organic solvents. However, their toxicity to various organisms has caused growing concern in recent years. Our study aims to evaluate the toxicity of 1-hexadecyl-3-methylimidazolium chloride ([C16 min]Cl) to human hepatocellular carcinoma (HepG2) cells, including cell viability, genotoxicity, oxidative stress, apoptosis, cell cycle, and apoptosis-related gene expression...
May 26, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Qixiang Ma, Haozhen Shao, Yanyan Feng, Linpeng Zhang, Pengshou Li, Xiaowei Hu, Zhitao Ma, Hua Lou, Xianwei Zeng, Guangbin Luo
PURPOSE: Excessive oxidative stress (OS) leads to cellular dysfunctions and cell death and constitutes a major cause of male infertility. However, the etiologies of increased ROS in male infertility is not fully understood. One major limitation is the lack of an in vivo imaging system that can be used to effectively study the impact of excessive ROS in the testis. Recently, we discovered that the hepatocellular carcinoma reporter (HCR) mice previously generated in our laboratory also expressed luciferase in the spermatids of the testis...
May 24, 2018: Free Radical Biology & Medicine
Kai Ding, Yannian Liao, Dinghao Gong, Xin Zhao, Wu Ji
We explored the ability of a long non-coding RNA H19, to influence oxidative stress (OS) and chemotherapy resistance of CD133 + cancer stem cells via the MAPK/ERK signaling pathway in HCC. HCC tissues with corresponding adjacent normal tissues were collected. CD133 + HuH7 cells were sorted and assigned into five groups. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting were performed to determine expression levels mRNAs and proteins. Levels of reactive oxygen species (ROS) and malonaldehyde (MDA), and activity of superoxide dismutase (SOD) were measured...
May 24, 2018: Biochemical and Biophysical Research Communications
Maria Lauda Tomasi, Komal Ramani
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. The large spectrum of protein post-translational modification (PTM) includes numerous critical signaling events that occur during neoplastic transformation. PTMs occur to nearly all proteins and increase the functional diversity of proteins. We have reviewed the role of two major PTMs, SUMOylation and phosphorylation, in the altered signaling of key players in HCC...
2018: Translational Gastroenterology and Hepatology
Heba Elmotasem, Hala K Farag, Abeer A A Salama
The objective of this study was to innovate an effective oral sustained release hepatoprotective formula for - the water soluble drug - caffeine. Caffeine is rapidly absorbed and eliminated which dictates frequent administration to achieve adequate therapeutic effect. A w/o Pickering emulsion incorporating caffeine in the internal phase was primed. It contained wheat germ oil and was stabilized by synthesized magnesium oxide nanoparticles (MgO NPs). Components selection was based on their antioxidant, hepatoprotective and anticarcinogenic effects...
May 16, 2018: International Journal of Pharmaceutics
Heidi Coia, Ning Ma, Aiwu Ruth He, Bhaskar Kallakury, Deborah L Berry, Eva Permaul, Kepher H Makambi, Ying Fu, Fung-Lung Chung
Background: Oxidative stress and chronic inflammation can increase cellular levels of reactive oxygen species and lipid peroxidation (LPO) when associated with the pathogenesis of hepatocellular carcinoma (HCC), which can develop following the progression of steatosis, fibrosis and cirrhosis. Using a monoclonal antibody for cyclic γ-hydroxy-1, N2 -propanodeoxyguanosine (γ-OHPdG), a promutagenic DNA adduct formed endogenously by LPO, we examined its formation across liver disease stages to understand it's potential role in HCC development...
April 2018: Hepatobiliary Surgery and Nutrition
Nina Kind, Anne Eckert, Célia Steinlin, Jörg M Fegert, Marc Schmid
OBJECTIVE: We investigated the impact of verbal and physical client aggression on risk of developing high hair cortisol concentration (HCC) as an indicator of chronic stress exposure and burnout in a Swiss population of professional caregivers working in youth residential care. METHOD: Participants (n = 121; 62.0% women) reported on client aggression and burnout symptoms and provided hair samples at four annual sampling points. HCC was determined in the first 1...
May 2, 2018: Psychoneuroendocrinology
Danielle E Jondal, Scott M Thompson, Kim A Butters, Bruce E Knudsen, Jill L Anderson, Rickey E Carter, Lewis R Roberts, Matthew R Callstrom, David A Woodrum
Purpose To determine if heat stress and hepatic laser thermal ablation induce hepatocellular carcinoma (HCC) growth and to identify growth factors induced by heat stress. Materials and Methods Non-heat-stressed HCC cells were cocultured with HCC cells or hepatocytes that were heat stressed at 37°C (physiologic), 45°C (moderate), or 50°C (severe) for 10 minutes and proliferation monitored with bioluminescence imaging for up to 6 days after heat stress (three experiments). Rats bearing orthotopic N1S1 HCC were randomly assigned to undergo immediate sham or laser thermal (3 W for 60 or 90 seconds; hereafter, 3W×60s and 3W×90s, respectively) ablation of the median (local) or left (distant) hepatic lobe, and tumor growth was monitored with magnetic resonance imaging for up to 18 days after ablation (six or more rats per group)...
May 8, 2018: Radiology
Jingtao Zhong, Xiaoming Yu, Xiaofeng Dong, Hong Lu, Wuyuan Zhou, Lei Li, Zhongchao Li, Pengfei Sun, Xuetao Shi
Recurrence and metastasis are the two leading causes of poor prognosis in patients with hepatocellular carcinoma (HCC). Secreted clusterin (sCLU) is a stress-induced chaperone that is overexpressed in HCC. However, the precise molecular mechanisms of sCLU in HCC invasion and migration are largely unknown. In the present study, it was indicated that downregulation of sCLU significantly alleviated invasiveness whereas overexpression of sCLU notably enhanced the number of invasive cells via mediating the expression level of MMP-2 and E-cadherin in Bel-7402 and SMMC-7721 cells...
May 2018: Oncology Letters
Fuwen Yuan, Chenzhong Xu, Guodong Li, Tanjun Tong
The nucleolus is an important organelle that is responsible for the biogenesis of ribosome RNA (rRNA) and ribosomal subunits assembly. It is also deemed to be the center of metabolic control, considering the critical role of ribosomes in protein translation. Perturbations of rRNA synthesis are closely related to cell proliferation and tumor progression. Telomeric repeat-binding factor 2 (TRF2) is a member of shelterin complex that is responsible for telomere DNA protection. Interestingly, it was recently reported to localize in the nucleolus of human cells in a cell-cycle-dependent manner, while the underlying mechanism and its role on the nucleolus remained unclear...
May 3, 2018: Cell Death & Disease
Erika Hernández-Aquino, Pablo Muriel
Liver diseases are caused by different etiological agents, mainly alcohol consumption, viruses, drug intoxication or malnutrition. Frequently, liver diseases are initiated by oxidative stress and inflammation that lead to the excessive production of extracellular matrix (ECM), followed by a progression to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). It has been reported that some natural products display hepatoprotective properties. Naringenin is a flavonoid with antioxidant, antifibrogenic, anti-inflammatory and anticancer properties that is capable of preventing liver damage caused by different agents...
April 28, 2018: World Journal of Gastroenterology: WJG
Hiroshi Yukawa, Kaoru Suzuki, Keita Aoki, Tomoko Arimoto, Takao Yasui, Noritada Kaji, Tetsuya Ishikawa, Takahiro Ochiya, Yoshinobu Baba
Hepatocellular carcinoma (HCC) is a typical hyper-vascular tumor, so the understanding the mechanisms of angiogenesis in HCC is very important for its treatment. However, the influence of the exosomes secreted from HCC cells (HCC-exosomes) on angiogenesis remains poorly understood. We herein examined the effects of the exosomes secreted from HepG2 cells (HepG2-exosomes) on the lumen formation of human umbilical vein endothelial cells (HUVECs) by the imaging of angiogenesis. The degree of lumen formation of HUVECs was dependent on the number of HepG2-exosomes...
April 30, 2018: Scientific Reports
Elham Ahmadian, Ahmad Yari Khosroushahi, Aziz Eftekhari, Safar Farajnia, Hossein Babaei, Mohammad Ali Eghbal
Overexpression of renin angiotensin system (RAS) components and nuclear factor-kappa B (NF-kB) has a key role in various cancers. Blockade of RAS and NF-kB pathway has been suggested to reduce cancer cell proliferation. This study aimed to investigate the role of angiotensin II and NF-kB pathway in liver hepatocellular carcinoma cell line (HepG2) proliferation by using azilsartan (as a novel Ag II antagonist) and Bay 11-7082 (as NF-kB inhibitor). HepG2 cells were treated with different concentrations of azilsartan and Bay 11-7082...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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