keyword
https://read.qxmd.com/read/38527697/sirt1-harnessing-multiple-pathways-to-hinder-nafld
#1
REVIEW
Cheng Tian, Rongrong Huang, Ming Xiang
Non-alcoholic fatty liver disease (NAFLD) encompasses hepatic steatosis, non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. It is the primary cause of chronic liver disorders, with a high prevalence but no approved treatment. Therefore, it is indispensable to find a trustworthy therapy for NAFLD. Recently, mounting evidence illustrates that Sirtuin 1 (SIRT1) is strongly associated with NAFLD. SIRT1 activation or overexpression attenuate NAFLD, while SIRT1 deficiency aggravates NAFLD...
March 23, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38524877/understanding-sorafenib-induced-cardiovascular-toxicity-mechanisms-and-treatment-implications
#2
REVIEW
Jue Li, Lusha Zhang, Teng Ge, Jiping Liu, Chuan Wang, Qi Yu
Tyrosine kinase inhibitors (TKIs) have been recognized as crucial agents for treating various tumors, and one of their key targets is the intracellular site of the vascular endothelial growth factor receptor (VEGFR). While TKIs have demonstrated their effectiveness in solid tumor patients and increased life expectancy, they can also lead to adverse cardiovascular effects including hypertension, thromboembolism, cardiac ischemia, and left ventricular dysfunction. Among the TKIs, sorafenib was the first approved agent and it exerts anti-tumor effects on hepatocellular carcinoma (HCC) and renal cell carcinoma (RCC) by inhibiting angiogenesis and tumor cell proliferation through targeting VEGFR and RAF...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38515850/gentiopicroside-improves-non-alcoholic-steatohepatitis-by-activating-ppar%C3%AE-and-suppressing-hif1
#3
JOURNAL ARTICLE
Chaoyuan Huang, Qiuhong Yong, Yihui Lu, Lu Wang, Yiyuan Zheng, Lina Zhao, Peiwu Li, Chong Peng, Wei Jia, Fengbin Liu
Gentiopicroside (GPS) is a highly water-soluble small-molecule drug and the main bioactive secoiridoid glycoside of Gentiana scabra that has been shown to have hepatoprotective effects against non-alcoholic steatohepatitis (NASH), a form of non-alcoholic fatty liver disease (NAFLD) that can progress to cirrhosis and hepatocellular carcinoma. However, the effects of GPS on NASH and the underlying mechanisms remain obscure. Firstly, a high-fat, high-cholesterol (HFHC) diet and a high-sugar solution containing d-fructose and d-glucose were used to establish a non-alcoholic steatohepatitis (NASH) mice model...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38504479/thymoquinone-protects-thioacetamide-induced-chronic-liver-injury-by-inhibiting-tgf-%C3%AE-1-smad3-axis-in-rats
#4
JOURNAL ARTICLE
Subramanian Raghunandhakumar, Devaraj Ezhilarasan, Karthik Shree Harini
Chronic liver injury due to various etiological factors results in excess secretion and accumulation of extracellular matrix proteins, leading to scarring of liver tissue and ultimately to hepatic fibrosis. If left untreated, fibrosis might progress to cirrhosis and even hepatocellular carcinoma. Thymoquinone (TQ), an active compound of Nigella sativa, has been reported to exhibit antioxidant, anti-inflammatory and anticancer activities. Therefore, the effect of TQ against thioacetamide (TAA)-induced liver fibrosis was assessed in rats...
April 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38500399/boldine-protects-against-carbon-tetrachloride-induced-chronic-liver-injury-by-regulating-nf-%C3%AE%C2%BAb-signaling-pathway
#5
JOURNAL ARTICLE
Devaraj Ezhilarasan, Karthik Shree Harini, Munusamy Karthick, Prathap Lavanya
Sustained liver injuries predominantly promote oxidative stress and inflammation that lead to the progression of chronic liver disease (CLD), including fibrosis, cirrhosis, and hepatocellular carcinoma. Boldine, an alkaloid isolated from Peumus boldus, has been shown to have antioxidant and anti-inflammatory effects. Currently, there is no definitive treatment option available for CLD. Therefore, we investigated the hepatoprotective effect of boldine against carbon tetrachloride (CCl4 )-induced chronic liver injury in rats...
April 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38499207/molecular-genealogy-of-metabolic-associated-hepatocellular-carcinoma
#6
JOURNAL ARTICLE
Takahiro Kodama, Tetsuo Takehara
This review examines the latest epidemiological and molecular pathogenic findings of metabolic-associated hepatocellular carcinoma (HCC). Its increasing prevalence is a significant concern and reflects the growing burden of obesity and metabolic diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), and type 2 diabetes. Metabolic-associated HCC has unique molecular abnormality and distinctive gene expression patterns implicating aberrations in bile acid, fatty acid metabolism, oxidative stress, and proinflammatory pathways...
March 18, 2024: Seminars in Liver Disease
https://read.qxmd.com/read/38495344/caffeine-in-hepatocellular-carcinoma-cellular-assays-animal-experiments-and-epidemiological-investigation
#7
REVIEW
Liang Shan, Ning Zhao, Fengling Wang, Dandan Zhai, Jianjun Liu, Xiongwen Lv
The use of caffeine in treating various liver diseases has made substantial progress in the past decade owing to advances in science, technology, and medicine. However, whether caffeine has a preventive effect on hepatocellular carcinoma (HCC) and its mechanism are still worth further investigation. In this review, we summarize and analyze the efficacy and safety of caffeine in the prevention of HCC. We conducted a review of articles published in PubMed and Web of Science in the past 2 decades until December 6, 2023, which were searched for using the terms "Caffeine" and "Hepatocellular Carcinoma...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38494997/investigation-of-apoptotic-effects-of-cucurbitacin-d-i-and-e-mediated-by-bax-bcl-xl-caspase-3-9-and-oxidative-stress-modulators-in-hepg2-cell-line
#8
JOURNAL ARTICLE
Muhammed Mehdi Üremiş, Yusuf Türköz, Nuray Üremiş
Cucurbitacins, natural compounds highly abundant in the Cucurbitaceae plant family, are characterized by their anticancer, anti-inflammatory, and hepatoprotective properties. These compounds have potential as therapeutic agents in the treatment of liver cancer. This study investigated the association of cucurbitacin D, I, and E (CuD, CuI, and CuE) with the caspase cascade, Bcl-2 family, and oxidative stress modulators in the HepG2 cell line. We evaluated the antiproliferative effects of CuD, CuI, and CuE using the MTT assay...
April 2024: Drug Development Research
https://read.qxmd.com/read/38492457/how-clspn-could-demystify-its-prognostic-value-and-potential-molecular-mechanism-for-hepatocellular-carcinoma-a-crosstalk-study
#9
JOURNAL ARTICLE
Yanlong Shi, Yizhu Wang, Kaiyi Niu, Wenning Zhang, Qingpeng Lv, Yewei Zhang
BACKGROUND & AIMS: CLSPN, a critical component of the S-phase checkpoint in response to DNA replication stress, has been implicated in the pathogenesis of multiple tumor types. The rising incidence of hepatocellular carcinoma (HCC) poses a significant challenge to global public health. Despite this, the specific functions of CLSPN in the development of HCC remain poorly understood. METHODS: We systematically evaluated the expression of CLSPN, prognosis and immune infiltration in patients with HCC and identified a competing endogenous RNA (ceRNA) network by using public database...
March 11, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38486060/unveiling-the-impact-of-hemodynamics-on-endothelial-inflammation-mediated-hepatocellular-carcinoma-metastasis-using-a-biomimetic-vascular-flow-model
#10
JOURNAL ARTICLE
Jia He, Peiyan Duan, Yi Liu, Tang Feng, Shuo Wang, Xinyi Lin, Jing Xie, Xiaoheng Liu
Distant metastasis of hepatocellular carcinoma (HCC) mediated by hematogenous dissemination is a leading cause of HCC-related deaths. The inflammatory response of vascular endothelial cells facilitates this process by promoting the adhesion and invasion of tumor cells in the circulatory system. While the regulation of this inflammation-mediated metastasis through upregulation of adhesion molecules and disruption of intercellular junctions has been well established, the contribution of hemodynamics to this process remains poorly understood due to the lack of a suitable vascular flow model for investigation...
March 14, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38482234/disulfidptosis-related-genes-of-prognostic-signature-and-immune-infiltration-features-in-hepatocellular-carcinoma-supported-by-bulk-and-single-cell-rna-sequencing-data
#11
JOURNAL ARTICLE
Yuyang Wang, Zibo Yuan, Qingwei Zhu, Jun Ma, Qiliang Lu, Zunqiang Xiao
BACKGROUND: Disulfidptosis is a new type of cellular death triggered in response to disulfide stress and is strongly linked to the progression of malignancies. Hepatocellular carcinoma (HCC) is a very common malignancy. Some reports have suggested a link between disulfidptosis-related genes (DRGs) and cancer; however, further research needs to be conducted. METHODS: In this study, HCC data from the Cancer Genome Atlas-Liver Hepatocellular Carcinoma and Gene Expression Omnibus data sets were collected and analyzed...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38476236/integrative-analysis-identifies-oxidative-stress-biomarkers-in-non-alcoholic-fatty-liver-disease-via-machine-learning-and-weighted-gene-co-expression-network-analysis
#12
JOURNAL ARTICLE
Haining Wang, Wei Cheng, Ping Hu, Tao Ling, Chao Hu, Yongzhen Chen, Yanan Zheng, Junqi Wang, Ting Zhao, Qiang You
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease globally, with the potential to progress to non-alcoholic steatohepatitis (NASH), cirrhosis, and even hepatocellular carcinoma. Given the absence of effective treatments to halt its progression, novel molecular approaches to the NAFLD diagnosis and treatment are of paramount importance. METHODS: Firstly, we downloaded oxidative stress-related genes from the GeneCards database and retrieved NAFLD-related datasets from the GEO database...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38474405/the-role-of-oxidative-stress-in-tumorigenesis-and-progression
#13
REVIEW
Kexin Li, Zhangyuzi Deng, Chunran Lei, Xiaoqing Ding, Jing Li, Changshan Wang
Oxidative stress refers to the imbalance between the production of reactive oxygen species (ROS) and the endogenous antioxidant defense system. Its involvement in cell senescence, apoptosis, and series diseases has been demonstrated. Advances in carcinogenic research have revealed oxidative stress as a pivotal pathophysiological pathway in tumorigenesis and to be involved in lung cancer, glioma, hepatocellular carcinoma, leukemia, and so on. This review combs the effects of oxidative stress on tumorigenesis on each phase and cell fate determination, and three features are discussed...
March 2, 2024: Cells
https://read.qxmd.com/read/38473913/hemochromatosis-ferroptosis-ros-gut-microbiome-and-clinical-challenges-with-alcohol-as-confounding-variable
#14
REVIEW
Rolf Teschke
Hemochromatosis represents clinically one of the most important genetic storage diseases of the liver caused by iron overload, which is to be differentiated from hepatic iron overload due to excessive iron release from erythrocytes in patients with genetic hemolytic disorders. This disorder is under recent mechanistic discussion regarding ferroptosis, reactive oxygen species (ROS), the gut microbiome, and alcohol abuse as a risk factor, which are all topics of this review article. Triggered by released intracellular free iron from ferritin via the autophagic process of ferritinophagy, ferroptosis is involved in hemochromatosis as a specific form of iron-dependent regulated cell death...
February 25, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473237/impact-of-hypoxia-on-radiation-based-therapies-for-liver-cancer
#15
REVIEW
Alexander Villalobos, Jean Lee, Sarah A Westergaard, Nima Kokabi
Background: Hypoxia, a state of low oxygen level within a tissue, is often present in primary and secondary liver tumors. At the molecular level, the tumor cells' response to hypoxic stress induces proteomic and genomic changes which are largely regulated by proteins called hypoxia-induced factors (HIF). These proteins have been found to drive tumor progression and cause resistance to drug- and radiation-based therapies, ultimately contributing to a tumor's poor prognosis. Several imaging modalities have been developed to visualize tissue hypoxia, providing insight into a tumor's microbiology...
February 22, 2024: Cancers
https://read.qxmd.com/read/38472423/the-cytotoxic-effects-of-prazosin-chlorpromazine-and-haloperidol-on-hepatocellular-carcinoma-and-immortalized-non-tumor-liver-cells
#16
JOURNAL ARTICLE
Seth Harris, Prithvi Nagarajan, Kyoungtae Kim
Liver cancer annually accounts for over 800,000 cases and 700,000 deaths worldwide. Hepatocellular carcinoma is responsible for over 80% of liver cancer cases. Due to ineffective treatment options and limited surgical interventions, hepatocellular carcinoma is notoriously difficult to treat. Nonetheless, drugs utilized for other medical conditions, such as the antihypertensive medication prazosin, the neuroleptic medication chlorpromazine, and the neuroleptic medication haloperidol, have gained attention for their potential anti-cancer effects...
March 12, 2024: Medical Oncology
https://read.qxmd.com/read/38472168/arnicolide-d-induces-endoplasmic-reticulum-stress-mediated-oncosis-via-atf4-and-chop-in-hepatocellular-carcinoma-cells
#17
JOURNAL ARTICLE
Yu-Shan Lin, Zhiwei Sun, Li-Sha Shen, Rui-Hong Gong, Jia-Wen Chen, Yanfeng Xu, Haiyang Yu, Sibao Chen, Guo-Qing Chen
Endoplasmic reticulum (ER) stress can trigger various cell death mechanisms beyond apoptosis, providing promise in cancer treatment. Oncosis, characterized by cellular swelling and increased membrane permeability, represents a non-apoptotic form of cell death. In our study, we discovered that Arnicolide D (AD), a natural sesquiterpene lactone compound, induces ER stress-mediated oncosis in hepatocellular carcinoma (HCC) cells, and this process is reactive oxygen species (ROS)-dependent. Furthermore, we identified the activation of the PERK-eIF2α-ATF4-CHOP pathway during ER stress as a pivotal factor in AD-induced oncosis...
March 12, 2024: Cell Death Discovery
https://read.qxmd.com/read/38471282/nuclear-translocation-of-metabolic-enzyme-pkm2-participates-in-high-glucose-promoted-hcc-metastasis-by-strengthening-immunosuppressive-environment
#18
JOURNAL ARTICLE
Jiali Qian, Chuxin Huang, Mimi Wang, Ying Liu, Yingying Zhao, Miao Li, Xi Zhang, Xiangyu Gao, Yawen Zhang, Yi Wang, Jinya Huang, Jiajun Li, Qiwen Zhou, Rui Liu, Xuanchun Wang, Jiefeng Cui, Yehong Yang
Although some cohort studies have indicated a close association between diabetes and HCC, the underlying mechanism about the contribution of diabetes to HCC progression remains largely unknown. In the study, we applied a novel HCC model in SD rat with diabetes and a series of high glucose-stimulated cell experiments to explore the effect of a high glucose environment on HCC metastasis and its relevant mechanism. Our results uncovered a novel regulatory mechanism by which nuclear translocation of metabolic enzyme PKM2 mediated high glucose-promoted HCC metastasis...
March 4, 2024: Redox Biology
https://read.qxmd.com/read/38468359/suppression-of-a-to-i-rna-editing-enzyme-adar1-sensitizes-hepatocellular-carcinoma-cells-to-oxidative-stress-through-regulating-keap1-nrf2-pathway
#19
JOURNAL ARTICLE
Houhong Wang, Xiaoyu Wei, Lu Liu, Junfeng Zhang, Heng Li
BACKGROUND: A-to-I RNA editing is an abundant post-transcriptional modification event in hepatocellular carcinoma (HCC). Evidence suggests that adenosine deaminases acting on RNA 1 (ADAR1) correlates to oxidative stress that is a crucial factor of HCC pathogenesis. The present study investigated the effect of ADAR1 on survival and oxidative stress of HCC, and underlying mechanisms. METHODS: ADAR1 expression was measured in fifty HCC and normal tissues via real-time quantitative PCR, and immunohistochemistry...
March 11, 2024: Experimental Hematology & Oncology
https://read.qxmd.com/read/38466833/early-onset-of-pathological-polyploidization-and-cellular-senescence-in-hepatocytes-lacking-rad51-creates-a-pro-fibrotic-and-pro-tumorigenic-inflammatory-microenvironment
#20
JOURNAL ARTICLE
Wenqing Bu, Xue Sun, Xiaotong Xue, Shengmiao Geng, Tingting Yang, Jia Zhang, Yanan Li, Chao Feng, Qiao Liu, Xiyu Zhang, Peishan Li, Zhaojian Liu, Yufang Shi, Changshun Shao
BACKGROUND AIMS: RAD51 is a highly conserved DNA repair protein and is indispensable for embryonic viability. As a result, the role of RAD51 in liver development and function is unknown. Our aim was to characterize the function of RAD51 in postnatal liver development. APPROACH RESULTS: RAD51 is highly expressed during liver development and during regeneration following hepatectomy and hepatic injury, and is also elevated in chronic liver diseases. We generated hepatocyte-specific Rad51 deletion mouse model using Alb-Cre (Rad51-CKO) and AAV8-TBG-Cre to evaluate the function of RAD51 in liver development and regeneration...
March 11, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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