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https://www.readbyqxmd.com/read/29222687/chrysophyllum-cainito-apple-star-a-fruit-with-gastroprotective-activity-in-experimental-ulcer-models
#1
Roseane Leandra da Rosa, Camila Leandra de Almeida, Lincon Bordigon Somensi, Thaise Boeing, Luisa Nathália Bolda Mariano, Clarissa de Medeiros Amorim Krueger, Priscila de Souza, Valdir Cechinel Filho, Luisa Mota da Silva, Sérgio Faloni de Andrade
The gastroprotective potential of the methanolic extracts from peels (MEPe), seeds (MESe) and pulp (MEPu) of Chrysophyllum cainito L. (Sapotaceae) fruits was evaluated in mice using ethanol/HCl- and indomethacin-induced ulcer, as well as the antiulcer effect of the juice and flour from this fruit. The lowest oral gastroprotective dose of MEPe, MESe and MEPu against ethanol/HCl was 3, 3 and 10 mg/kg, respectively. Moreover, all extracts increased mucin secretion at 176, 198 and 193%. Intraperitoneal administration of MEPe (0...
December 8, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29220339/to-flavor-or-not-to-flavor-extemporaneous-omeprazole-liquid
#2
Monica C Chuong, Catherine A Taglieri, Stephen G Kerr
Omeprazole is a proton pump inhibitor used to treat the symptoms of gastro esophageal reflux disease, ulcers, excess stomach acid, infection with Helicobacter pylori, and to control the gastric side effects of various drugs. The approved dosage forms in the U.S. are powder in compounding kits, delayed-release granules for oral suspension, oral delayed-release tablets, and oral delayed-release capsules. An extemporaneously compounded unsweetened oral liquid method, published in the International Journal of Pharmaceutical Compounding, was found to be commonly used by pharmacists...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29219052/adverse-events-of-proton-pump-inhibitors-potential-mechanisms
#3
Andrea Corsonello, Fabrizia Lattanzio, Silvia Bustacchini, Sabrina Garasto, Annalisa Cozza, Roberto Schepisi, Federica Lenci, Filippo Luciani, Marcello Giuseppe Maggio, Andrea Ticinesi, Valeria Butto, Sara Tagliaferri, Francesco Corica
OBJECTIVE: We aimed at summarizing current evidence about mechanisms for potentially harmful effects of proton pump inhibitors (PPIs). METHODS: A Pubmed search was performed, and 207 studies concerning the relationship between use of PPIs and cardiovascular diseases, kidney impairment, nutritional disorders, fractures, infections, functional decline, and mortality were selected and reviewed. RESULTS: PPIs may cause potentially harmful effects by several mechanisms, including endothelial dysfunction, hypomagnesemia, drug interactions, reduced absorption of selected nutrients, increased gastric microbiota and small intestine bacterial overgrowth, reduced immune response, tubular-interstitial inflammation, increased bone turnover, accumulation of amyloid in the brain...
December 7, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29217908/a-novel-method-for-pain-relief-in-chronic-pancreatitis-an-old-drug-in-a-new-pack-a-controlled-study
#4
Aswini Kumar Pujahari
Most of pain-relieving agents in chronic pancreatitis are nonspecific and unpredictable. Omeprazole induces hypergastrinemia due to reduced gastric acidity. Raised serum gastrin, in turn, modulates to reduce secretin level. Secretin is responsible for secretion of almost 80 % bicarbonate-rich pancreatic juice from the ductular epithelium without affecting enzyme output. It is a prospective randomized study in patients with CT-confirmed chronic pancreatitis. The control group got the standard care and 60 mg of omeprazole twice daily was added to the test group...
December 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29215629/proton-pump-inhibitors-and-dementia-deciphering-the-data
#5
Paul Moayyedi, Maxine A Lewis
Proton pump inhibitors (PPIs) are effective and suppressing acid, and therefore have efficacy against gastric acid-related disorders. The long-term safety of PPIs is less clear and there have been a number of studies raising concerns regarding risk of pneumonia, fracture, Clostridium difficile, chronic renal failure, and dementia. This latter concern is addressed by a study in this issue of AJG using health care registry data and found there was no association between PPI use and Alzheimer's dementia. Furthermore, there was no increased risk of dementia with long-term use of PPIs or higher doses of PPIs...
December 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29214885/short-term-efficacy-of-potassium-competitive-acid-blocker-following-gastric-endoscopic-submucosal-dissection-a-propensity-score-analysis
#6
Yohei Horikawa, Hiroya Mizutamari, Nobuya Mimori, Yuhei Kato, Saki Fushimi, Sayaka Sato, Syunji Okubo
BACKGROUND: Endoscopic submucosal dissection (ESD) is a promising method for the resection of superficial gastric neoplasms. Vonoprazan is a novel potassium-competitive acid blocker (P-CAB) that is currently considered as a potential alternative to proton pump inhibitors (PPIs) for the treatment of acid-related diseases. However, the utility of vonoprazan in ESD-related ulcers is unclear. Therefore, we compared the short-term efficacies of vonoprazan and the PPI lansoprazole in ESD-related ulcer healing during the first two weeks following intervention...
December 7, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29214609/soy-protein-microparticles-for-enhanced-oral-ibuprofen-delivery-preparation-characterization-and-in-vitro-release-evaluation
#7
Maria Antonieta Anaya Castro, Isabelle Alric, Fabien Brouillet, Jérôme Peydecastaing, Sophie Girod Fullana, Vanessa Durrieu
The objective of this work was to evaluate soy protein isolate (SPI) and acylated soy protein (SPA) as spray-drying encapsulation carriers for oral pharmaceutical applications. SPI acylation was performed by the Schotten-Baumann reaction. SPA, with an acylation rate of 41%, displayed a decrease in solubility in acidic conditions, whereas its solubility was unaffected by basic conditions. The drug encapsulation capacities of both SPI and SPA were tested with ibuprofen (IBU) as a model poorly soluble drug. IBU-SPI and IBU-SPA particles were obtained by spray-drying under eco-friendly conditions...
December 6, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29213351/spondias-purpurea-l-anacardiaceae-antioxidant-and-antiulcer-activities-of-the-leaf-hexane-extract
#8
Cynthia Layse Ferreira de Almeida, Samara Alves Brito, Temístocles Italo de Santana, Henrique Bandeira Alves Costa, Carlson Helder Reis de Carvalho Júnior, Márcia Vanusa da Silva, Lécio Leone de Almeida, Larissa Araújo Rolim, Vanda Lucia Dos Santos, Almir Gonçalves Wanderley, Teresinha Gonçalves da Silva
Spondias purpurea is used in folk medicine to treat diarrhea and diuresis. The objective of this study was to evaluate the phytochemical profile and antioxidant and antiulcer activities of the hexane extract of the leaves of S. purpurea (SpHE). Phytochemical profile was evaluated via thin layer chromatography (TLC) and HPLC. SpHE was screened for antioxidant activities using DPPH, ABTS, FRAP, and phosphomolybdenum assays. To determine its antiulcer properties, animals were pretreated with injured control, lansoprazole, ranitidine, carbenoxolone, or SpHE (12...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29213286/survival-of-five-strains-of-shiga-toxigenic-escherichia-coli-in-a-sausage-fermentation-model-and-subsequent-sensitivity-to-stress-from-gastric-acid-and-intestinal-fluid
#9
Tone Mari Rode, Anette McLeod, Ingrid Måge, Even Heir, Lars Axelsson, Askild L Holck
The ability of foodborne pathogens to exhibit adaptive responses to stressful conditions in foods may enhance their survival when passing through the gastrointestinal system. We aimed to determine whether Escherichia coli surviving stresses encountered during a model dry-fermented sausage (DFS) production process exhibit enhanced tolerance and survival in an in vitro gastrointestinal model. Salami sausage batters spiked with five E. coli isolates, including enterohaemorrhagic E. coli strains isolated from different DFS outbreaks, were fermented in a model DFS process (20°C, 21 days)...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/29212851/omics-of-bifidobacteria-research-and-insights-into-their-health-promoting-activities
#10
REVIEW
Francesca Bottacini, Douwe van Sinderen, Marco Ventura
Members of the genus Bifidobacterium include gut commensals that are particularly abundant among the microbial communities residing in the gut of healthy breast-fed infants, where their presence has been linked to many beneficial host effects. Next-generation DNA sequencing and comparative and functional genome methodologies have been shown to be particularly useful in exploring the diversity of this genus. These combined approaches have allowed the identification of genetic features related to bifidobacterial establishment in the gut, involving host-microbe as well as microbe-microbe interactions...
December 6, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29212330/gastric-mucus-and-mucuslike-hydrogels-thin-film-lubricating-properties-at-soft-interfaces
#11
Troels Røn, Navin J Patil, Fatemeh Ajalloueian, Sankaranarayanan Rishikesan, Bruno Zappone, Ioannis S Chronakis, Seunghwan Lee
Mucus is a viscous slime that plays a vital role in protecting and lubricating biological tissues, in particular, soft epithelium interfaces such as in the stomach, intestines, and esophagus. Previous attempts to generate mucus models that mimick or simulate its characteristics have been predominantly focused on the rheological properties. This study investigates both rheological and tribological shear properties of thin films of gastric mucus from a porcine source and its mimics at compliant soft interfaces...
December 5, 2017: Biointerphases
https://www.readbyqxmd.com/read/29212068/activation-of-secretagogue-independent-gastric-acid-secretion-via-endothelial-nitric-oxide-synthase-stimulation-in-rats
#12
Alice Miriam Kitay, Alexander Link, John P Geibel
BACKGROUND/AIMS: L-arginine is an important mediator of cell division, wound healing, and immune function. It can be transformed by the nitric oxide synthase (NOS) to nitric oxide (NO), an important cell signaling molecule. Recent studies from our laboratory demonstrate specific effects of L-arginine (10mM) exposure on gastric acid secretion in rat parietal cells. METHODS: Studies were performed with isolated gastric glands and the pH sensitive dye BCECF-AM +/- L-arginine to examine its effects on acid secretion...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29211685/optimisation-of-sampling-parameters-for-standardised-exhaled-breath-sampling
#13
Sophie L F Doran, Andrea Romano, George B Hanna
The lack of standardisation of breath sampling is a major contributing factor to the poor repeatability of results and hence represents a barrier to the adoption of breath tests in clinical practice. On-line and bag breath sampling have advantages but do not suit multicentre clinical studies whereas storage and robust transport are essential for the conduct of wide-scale studies. Several devices have been developed to control sampling parameters and to concentrate volatile organic compounds (VOCs) onto thermal desorption (TD) tubes and subsequently transport those tubes for laboratory analysis...
December 6, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29209743/gastroprotective-activity-of-the-methanol-extract-from-peels-of-plinia-edulis-vell-sobral-fruits-and-its-isolated-triterpenes-maslinic-and-ursolic-acids
#14
Roseane Leandra da Rosa, Luciane Ângela Nottar Nesello, Luisa Nathalia Bolda Mariano, Lincon Bordignon Somensi, Adriana Campos, Ana Myrelle Pinheiro, Sabrina Costa, Marjana Rial, Mariana Tozzo, Valdir Cechinel-Filho, Sérgio Faloni de Andrade, Luísa Mota Da Silva
According to the Brazilian folk medicine, the leaves of Plinia edulis (Vell.) Sobral (Myrtaceae), known as cambuca, are indicated in the treatment of gastric disorders. Infusions of P. edulis leaves were previously demonstrated to contain both maslinic (MA) and ursolic acids (UA). Both triterpenes have also been identified in the methanolic extract of peels from P. edulis fruit (MEPPE); however, the antiulcer effects of MEPPE have not yet been studied. This study therefore evaluates the gastroprotective potential of MEPPE, MA, and UA using ethanol/HCl- and indomethacin-induced gastric ulcers in mice...
December 5, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29208276/development-of-novel-ph-sensitive-thiolated-chitosan-pmla-nanoparticles-for-amoxicillin-delivery-to-treat-helicobacter-pylori
#15
Muhammad Arif, Quan-Jiang Dong, Mazhar Ali Raja, Shah Zeenat, Zhe Chi, Chen-Guang Liu
The cysteine conjugated chitosan/PMLA multifunctional nanoparticles were synthesized as targeted Nano-drug delivery system to eradicate Helicobacter pylori. Helicobacter pylori specifically express urea transport protein on its membrane to carrying urea to the cytoplasm urease to supply ammonia that protects bacteria in the acid environment of the stomach. The clinical suitability of topical antimicrobial agents is required to get rid of Helicobacter pylori inside the inflamed basal region. In this work, cysteine conjugated chitosan derivative, Cys-CS for their mucoadhesive and anticoagulant properties was designed and synthesized, for the preparation of multifunctional nanoparticles...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29208252/sporadic-fundic-gland-polyps-and-gastric-acid-suppression-level
#16
Mohamed Khalaf, Andrew S Brock, Donald Castell
BACKGROUND: Fundic gland polyps (FGPs) are a common endoscopic finding and are known to be associated with proton pump inhibitors (PPIs) use. It is not known if their prevalence is affected by gastric acidity levels. This study aimed to assess whether there is a correlation between FGPs and gastric acidity levels as identified on 24-hour ambulatory impedance-pH studies in patients on PPI therapy. METHODS: We performed a review of 402 consecutive patients who take at least once daily PPI and underwent esophagogastroduodenoscopy with combined impedance-pH studies in the same setting (time and place) between January 2010 and December 2014...
December 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29204429/acid-suppressive-therapy-improved-symptoms-due-to-circumferential-cervical-inlet-patch-with-proton-pumps-h-k-atpase
#17
Takanori Yamada, Atsushi Tsuji, Shunya Onoue, Masanao Kaneko, Fumihiko Tanioka, Satoshi Osawa, Yasuhiko Saida
Cervical inlet patch (CIP), also referred to as esophageal heterotopic gastric mucosa, is regarded as the residue of columnar epithelium of the embryonic esophagus. Narrow band imaging increases the detection rate of CIP. Herein, we present a 55-year-old man with symptomatic circumferential inlet patch. He exhibited globus and dysphagia, and esophagogastroduodenoscopy found cir-cumferential CIP, where im-munohistochemistry revealed the existence of pro-ton pumps (H+, K+-ATPase). His throat symptoms were relieved by acid suppressive therapy with pump inhibitors...
November 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29204059/potential-rat-model-of-anxiety-like-gastric-hypersensitivity-induced-by-sequential-stress
#18
Fu-Chun Jing, Jun Zhang, Chen Feng, Yuan-Yuan Nian, Jin-Hai Wang, Hao Hu, Bao-De Yang, Xiao-Ming Sun, Jian-Yun Zheng, Xiao-Ran Yin
AIM: To establish a rat model of anxiety-like gastric hypersensitivity (GHS) of functional dyspepsia (FD) induced by novel sequential stress. METHODS: Animal pups were divided into two groups from postnatal day 2: controls and the sequential-stress-treated. The sequential-stress-treated group received maternal separation and acute gastric irritation early in life and restraint stress in adulthood; controls were reared undisturbed with their mothers. Rats in both groups were followed to adulthood (8 wk) at which point the anxiety-like behaviors and visceromotor responses to gastric distention (20-100 mmHg) and gastric emptying were tested...
November 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29203960/monascus-purpureus-induced-apoptosis-on-gastric-cancer-cell-by-scavenging-mitochondrial-reactive-oxygen-species
#19
Hiromi Kurokawa, Hiromu Ito, Hirofumi Matsui
Monascus purpureus is a red dye derived from yeast rice and has been used as color additives for food in East Asia. Monascus purpureus consists of several bioactive components. Some of these components work as a radical scavenger, thus monascus purpureus would also eliminate reactive oxygen species. Cancer cells maintain the high level of reactive oxygen species than normal cell and are death by imbalance in pro-oxidant/antioxidant homeostasis. In this study, we investigated whether monascus purpureus induced cancer specific cell death by scavenging reactive oxygen species...
November 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29203406/acid-and-nonacid-gastroesophageal-reflux-after-single-anastomosis-gastric-bypass-an-objective-assessment-using-24-hour-multichannel-intraluminal-impedance-ph-metry
#20
Georgia Doulami, Stamatina Triantafyllou, Konstantinos Albanopoulos, Maria Natoudi, Georgios Zografos, Dimitrios Theodorou
BACKGROUND: Single anastomosis gastric bypass (SaGB) was introduced in 2001 as an alternative to "loop" gastric bypass. It was considered as a procedure that would eliminate alkaline reflux and associated esophagitis. OBJECTIVES: Existing evidence about the postoperative incidence of gastroesophageal reflux (GERD) after SaGB is based on studies using symptom questionnaires. The aim of our study was to evaluate GERD 12 months after SaGB by using 24-hour multichannel intraluminal impedance pH metry (24-h MIIpH)...
October 26, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
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