keyword
MENU ▼
Read by QxMD icon Read
search

Gastric acid

keyword
https://www.readbyqxmd.com/read/29672271/anti-ulcerogenic-effect-of-the-methanol-extract-of-chasmanthera-dependens-hochst-stem-on-male-wistar-rats
#1
Stephanie Abiola Tijani, Samuel B Olaleye, Ebenezer O Farombi
BACKGROUND: Oxidative stress and free radical-mediated processes have been implicated in the pathogenesis of indomethacin-induced gastric ulcer. This study investigated the ability of the methanol extract of Chasmanthera dependens to protect the gastric mucosal from oxidative damage induced by oral administration of indomethacin in rats. METHODS: The C. dependens stems were chopped into pieces, air-dried, and pulverized into powder. One kilogram of the powder was macerated in 1 L of methanol for 72 h...
April 19, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29670757/gastric-inhibitory-polypeptide-receptor-antagonist-skl-14959-suppressed-body-weight-gain-on-diet-induced-obesity-mice
#2
T Nakamura, H Tanimoto, Y Mizuno, M Okamoto, M Takeuchi, Y Tsubamoto, H Noda
Objective: Gastric inhibitory polypeptide plays a role in glucose and lipid metabolism and is associated with obesity and insulin resistance. The objective of this study is to confirm the anti-obesity effects of the gastric inhibitory polypeptide receptor antagonist, SKL-14959, on diet-induced obesity mice. Method: Diet-induced obesity mice at 20 weeks of age were administered with or without SKL-14959 for 96 d. Body weight and food intake were monitored throughout the experiment...
April 2018: Obesity Science & Practice
https://www.readbyqxmd.com/read/29670347/alpcs-4-pdt-for-gastric-cancer-therapy-using-gold-nanorod-cationic-liposome-and-pluronic-%C3%A2-f127-nanomicellar-drug-carriers
#3
Jing Xin, Sijia Wang, Bing Wang, Jiazhuang Wang, Jing Wang, Luwei Zhang, Bo Xin, Lijian Shen, Zhenxi Zhang, Cuiping Yao
Purpose: As a promising photodynamic therapy (PDT) agent, Al(III) phthalocyanine chloride tetrasulfonic acid (AlPcS4 ) provides deep penetration into tissue, high quantum yields, good photostability, and low photobleaching. However, its low delivery efficiency and high binding affinity to serum albumin cause its low penetration into cancer cells, further limiting its PDT effect on gastric cancer. In order to improve AlPcS4 /PDT effect, the AlPcS4 delivery sys tems with different drug carriers were synthesized and investigated...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29670108/down-regulation-of-a-pro-apoptotic-pathway-regulated-by-pcaf-ada3-in-early-stage-gastric-cancer
#4
Daniella Brasacchio, Rita A Busuttil, Tahereh Noori, Ricky W Johnstone, Alex Boussioutas, Joseph A Trapani
The loss of p300/CBP-associated protein (PCAF) expression is associated with poor clinical outcome in gastric cancer, and a potential bio-marker for invasive and aggressive tumors. However, the mechanism linking loss of PCAF to the onset of gastric cancer has not been identified. Given that PCAF and its binding partner transcriptional adaptor protein 3 (ADA3) were recently shown to regulate the intrinsic (mitochondrial) pathway to apoptosis via epigenetic regulation of phosphofurin acidic cluster sorting proteins 1 and 2 (PACS1, PACS2), we analyzed PCAF, ADA3, and PACS1/2 expression in 99 patient-matched surgical samples ranging from normal gastric mucosa, through pre-malignant chronic gastritis and intestinal metaplasia to stage I-III invasive cancers...
April 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29668670/exosomes-released-by-gastric-cancer-cells-induce-transition-of-pericytes-into-cancer-associated-fibroblasts
#5
Xiaofei Ning, Hongran Zhang, Cong Wang, Xiuqi Song
BACKGROUND Cancer-associated fibroblasts (CAFs) are functionally and structurally essential for tumor progression. There are 3 main origins of CAFs: mesenchymal stem cells (MSCs), epithelial-to-mesenchymal (EMT) transition cells, and tissue-resident cells. Pericytes retain characteristics of progenitor cells and can differentiate into other cells under normal physiological conditions and into myofibroblasts under pathological conditions. Exosomes play an important role in intercellular communication by transferring membrane components and nucleic acids between different cells...
April 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29666306/truncation-and-motif-based-pan-cancer-analysis-reveals-tumor-suppressing-kinases
#6
Andrew M Hudson, Natalie L Stephenson, Cynthia Li, Eleanor Trotter, Adam J Fletcher, Gitta Katona, Patrycja Bieniasz-Krzywiec, Matthew Howell, Chris Wirth, Simon Furney, Crispin J Miller, John Brognard
A major challenge in cancer genomics is identifying "driver" mutations from the many neutral "passenger" mutations within a given tumor. To identify driver mutations that would otherwise be lost within mutational noise, we filtered genomic data by motifs that are critical for kinase activity. In the first step of our screen, we used data from the Cancer Cell Line Encyclopedia and The Cancer Genome Atlas to identify kinases with truncation mutations occurring within or before the kinase domain...
April 17, 2018: Science Signaling
https://www.readbyqxmd.com/read/29665689/the-human-sweet-receptor-t1r3-is-functional-in-human-gastric-parietal-tumor-cells-hgt-1-and-modulates-cyclamate-and-acesulfame-k-induced-mechanisms-of-gastric-acid-secretion
#7
Muhammet Zopun, Kathrin I Liszt, Verena Stoeger, Maik Behrens, Ulrike Redel, Jakob P Ley, Joachim Hans, Veronika Somoza
The non-caloric sweeteners (NCS) cyclamate (Cycl) and acesulfame K (AceK) are widely added to foods and beverages. Little is known about their impact on gastric acid secretion (GAS), which is stimulated by dietary protein and bitter-tasting compounds. Since Cycl and AceK have a bitter off-taste in addition to their sweet-taste, we hypothesized they modulate mechanisms of GAS in human gastric parietal cells (HGT-1). HGT-1 cells were exposed to sweet tastants (50 mM of glucose, D-threonine, Cycl or AceK), and analyzed for their intracellular pH index (IPX), as indicator of proton secretion by means of a pH-sensitive dye, and for mRNA-levels of GAS-associated genes by RT-qPCR...
April 17, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29665355/combination-therapy-with-polydeoxyribonucleotide-and-proton-pump-inhibitor-enhances-therapeutic-effectiveness-for-gastric-ulcer-in-rats
#8
Il-Gyu Ko, Sung-Eun Kim, Jun-Jang Jin, Lakkyong Hwang, Eun-Sang Ji, Chang-Ju Kim, Jin-Hee Han, In Taik Hong, Min Seop Kwak, Jin Young Yoon, Hyun Phil Shin, Jung Won Jeon
AIMS: The main action of proton pump inhibitors (PPIs) is to inhibit gastric acid secretion, and PPIs are widely used to treat gastric ulcer (GU). However, if the action of promoting gastric mucosal regeneration is added, the effectiveness of GU treatment can be enhanced. Thus, in order to improve the therapeutic effect on GU, we tried to develop combination therapy promoting regeneration in injured tissue besides suppressing gastric acid secretion. MAIN METHODS: Polydeoxyribonucleotide (PDRN) was selected to evaluate tissue regeneration, and pantoprazole was chosen as one of the PPIs...
April 14, 2018: Life Sciences
https://www.readbyqxmd.com/read/29663561/concise-machinery-for-monitoring-ubiquitination-activities-using-novel-artificial-ring-fingers
#9
REVIEW
Kazuhide Miyamoto, Kazuki Saito
Protein ubiquitination is involved in many cellular processes, such as protein degradation, DNA repair, and signal transduction pathways. Ubiquitin-conjugating (E2) enzymes of the ubiquitination pathway are associated with various cancers, such as leukemia, lung cancer, and gastric cancer. However, to date, detection of E2 activities is not practicable for capturing the pathological conditions of cancers due to complications related to the enzymatic cascade reaction. To overcome this hurdle, we have recently investigated a novel strategy for measuring E2 activities...
April 16, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29662844/mineral-elements-bio-accessibility-and-antioxidant-indices-of-blanched-basella-rubra-at-different-phases-of-in-vitro-gastrointestinal-digestion
#10
Sule Ola Salawu, Bukola Eugenia Olukemi, Ikuosho Charity Asikhia, Akintunde Afolabi Akindahunsi
The present investigation was designed to evaluate the mineral element bio-accessibility and antioxidant indices of blanched Basella rubra at different phases of simulated in vitro digestion (oral, gastric, and intestinal). The phenolic composition of processed vegetable was determined using high-performance liquid chromatography (HPLC)-diode-array detection method. Mineral composition, total phenolic content (TPC), total flavonoid content (TFC), ferric reducing antioxidant power (FRAP), and total antioxidant activity (TAA) of the in vitro digested blanched and raw vegetable were also determined...
March 2018: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29662293/maintenance-for-healed-erosive-esophagitis-phase-iii-comparison-of-vonoprazan-with-lansoprazole
#11
Kiyoshi Ashida, Katsuhiko Iwakiri, Naoki Hiramatsu, Yuuichi Sakurai, Tetsuharu Hori, Kentarou Kudou, Akira Nishimura, Eiji Umegaki
AIM: To compare vonoprazan 10 and 20 mg vs lansoprazole 15 mg as maintenance therapy in healed erosive esophagitis (EE). METHODS: A total of 607 patients aged ≥ 20 years, with endoscopically-confirmed healed EE following 8 wk of treatment with vonoprazan 20 mg once daily, were randomized 1:1:1 to receive lansoprazole 15 mg ( n = 201), vonoprazan 10 mg ( n = 202), or vonoprazan 20 mg ( n = 204), once daily. The primary endpoint of the study was the rate of endoscopically-confirmed EE recurrence during a 24-wk maintenance period...
April 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29660650/evidence-for-gastroprotective-anti-inflammatory-and-antioxidant-potential-of-methanolic-extract-of-cordia-dichotoma-leaves-on-indomethacin-and-stress-induced-gastric-lesions-in-wistar-rats
#12
Ketan Vinayakrao Hatware, Sanjay Sharma, Kiran Patil, Meghanath Shete, Sravani Karri, Gaurav Gupta
The Cordia dichotoma (CD) is having anticancer and other pharmacological effects as it contains mainly flavonoids. The present study was aimed to demonstrate the gastroprotective effect of methanolic extract of CD leaves (MECD) obtained using Soxhlet extractor. In this study the qualitative phytochemical analysis of MECD revealed the presence of bioflavonoids and determination of quercetin was confirmed by HPLC analysis. The MECD was administered orally at doses 50 mg/kg, 100 mg/kg and 200 mg/kg against indomethacin induced gastric ulceration and stress-induced gastric ulceration in Wistar rats...
April 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29659969/aspartame-consumption-for-12-weeks-does-not-affect-glycemia-appetite-or-body-weight-of-healthy-lean-adults-in-a-randomized-controlled-trial
#13
Kelly A Higgins, Robert V Considine, Richard D Mattes
Background: Low-calorie sweeteners are often used to moderate energy intake and postprandial glycemia, but some evidence indicates that they may exacerbate these aims. Objective: The trial's primary aim was to assess the effect of daily aspartame ingestion for 12 wk on glycemia. Effects on appetite and body weight were secondary aims. Methods: One hundred lean [body mass index (kg/m2): 18-25] adults aged 18-60 y were randomly assigned to consume 0, 350, or 1050 mg aspartame/d (ASP groups) in a beverage for 12 wk in a parallel-arm design...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29658029/in-vitro-lipid-digestion-in-raw-and-roasted-hazelnut-particles-and-oil-bodies
#14
Edoardo Capuano, Nicoletta Pellegrini, Eleni Ntone, Constantinos V Nikiforidis
Previous studies have proved that the physical encapsulation of nutrients by the cell walls of plant foods modulates macronutrient bioaccessibility during human digestion. In this study, we investigated structural factors that modulate lipid hydrolysis during in vitro digestion of raw and roasted hazelnut particles and isolated oil bodies. Isolated oil bodies exhibited a significantly higher lipid hydrolysis compared to hazelnut particles. Moreover, roasting had an impact on the structure of hazelnut cell walls implying a more efficient diffusion of digestive fluids and enzymes into the hazelnut cells...
April 16, 2018: Food & Function
https://www.readbyqxmd.com/read/29656158/toxicogenetic-study-of-omeprazole-and-the-modulatory-effects-of-retinol-palmitate-and-ascorbic-acid-on-allium-cepa
#15
Antonio Lima Braga, Ag-Anne Pereira Melo de Meneses, José Victor de Oliveira Santos, Antonielly Campinho Dos Reis, Rosália Maria Tôrres de Lima, Ana Maria Oliveira Ferreira da Mata, Márcia Fernanda Correia Jardim Paz, Leane Brunelle Dos Santos Alves, Subrata Shaw, Shaikh Jamal Uddin, Razina Rouf, Asish Kumar Das, Shrabanti Dev, Manik Chandra Shil, Jamil A Shilpi, Ishaq N Khan, Muhammad Torequl Islam, Eunüs S Ali, Mohammad S Mubarak, Siddhartha Kumar Mishra, João Marcelo de Castro E Sousa, Ana Amélia de Carvalho Melo-Cavalcante
Omeprazole (OME) is a proton pump inhibitor used for the treatment of various gastric and intestinal disease; however, studies on its effects on the genetic materials are still restricted. The present study aimed to evaluate possible toxicogenic effects of OME in Allium cepa meristems with the application of cytogenetic biomarkers for DNA damage, mutagenic, toxic and cytotoxic effects. Additionally, retinol palmitate (RP) and ascorbic acid (AA) were also co-treated with OME to evaluate possible modulatory effects of OME-induced cytogenetic damages...
April 5, 2018: Chemosphere
https://www.readbyqxmd.com/read/29655655/hypothalamic-peroxisome-proliferator-activated-receptor-gamma-regulates-ghrelin-production-and-food-intake
#16
Qingjie Li, Quan Yu, Li Lin, Heng Zhang, Miao Peng, Chunxia Jing, Geyang Xu
Peroxisome proliferator-activated receptor-γ (PPARγ) regulates fatty acid storage, glucose metabolism, and food intake. Ghrelin, a gastric hormone, provides a hunger signal to the central nervous system to stimulate appetite. However, the effects of PPARγ on ghrelin production are still unclear. In the present study, the effects of PPARγ on ghrelin production were examined in lean- or high-fat diet-induced obese (DIO) C57BL/6J mice and mHypoE-42 cells, a hypothalamic cell line. 3rd intracerebroventricular injection of adenoviral-directed overexpression of PPARγ (Ad-PPARγ) reduced hypothalamic and plasma ghrelin, food intake in both lean C57BL/6J mice and diet-induced obese mice...
April 9, 2018: Neuropeptides
https://www.readbyqxmd.com/read/29651969/synthesis-characterization-of-ethyl-5-substituted-1h-pyrazole-3-carboxylate-derivative-as-potent-anti-inflammatory-agents
#17
Sujeet Kumar Gupta, Pratik Khanal, Arun Kumar, Arun Kumar, Neha Srivastava, Bhumika Yogi, Anshuman Sinha
BACKGROUND: Recently, pyrazole derivatives have shown significant anti-inflammatory activity. Non-steroidal anti-inflammatory drugs have the drawbacks of such as gastric irritation and gastric ulceration in treatment of inflammation. So the current study deals with the synthesis and pharmacological evaluation of a series of novel pyrazole derivatives as anti-inflammatory agents. METHODS: A series of novel ethyl 5-(substituted)-1H-pyrazole-3-carboxylate (2a-j) were synthesized and evaluated for anti-inflammatory activity using carrageenan-induced inflammation in rat paw edema model...
April 11, 2018: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29650943/-a-useful-case-of-photodynamic-diagnosis-of-inferior-vena-cava-invasion-by-pancreatic-head-cancer-using-5-aminolevulinic-acid-5-ala
#18
Toru Mizutani, Yasutoshi Murayama, Hisashi Ikoma, Tomohiro Arita, Toshiyuki Kosuga, Hirotaka Konishi, Ryo Morimura, Atsushi Shiozaki, Yoshiaki Kuriu, Masayoshi Nakanishi, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji
Curative resection is necessary to survival in pancreatic cancer, however after surgery, pathologic examination sometimes diagnoses the remains of cancer at the resected stump. Therefore, it is necessary to evaluate the stump by intraoperative rapid pathological examination. 5-aminolevulinic acid(5-ALA)is an endogenous natural amino acid and precursor of the heme pathway. 5-ALA is metabolized and accumulated as protoporphyrin IX(Pp IX)that is photosensitive substance. 5-ALA mediated photodynamic diagnosis(PDD)(ALA-PDD)has high diagnostic ability...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29649994/bile-acids-at-neutral-and-acidic-ph-induce-apoptosis-and-gene-cleavages-in-nasopharyngeal-epithelial-cells-implications-in-chromosome-rearrangement
#19
Sang-Nee Tan, Sai-Peng Sim
BACKGROUND: Chronic rhinosinusitis (CRS) increases the risk of developing nasopharyngeal carcinoma (NPC) while nasopharyngeal reflux is known to be one of the major aetiological factors of CRS. Bile acid (BA), the component of gastric duodenal contents, has been recognised as a carcinogen. BA-induced apoptosis was suggested to be involved in human malignancies. Cells have the potential and tendency to survive apoptosis. However, cells that evade apoptosis upon erroneous DNA repair may carry chromosome rearrangements...
April 12, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29643293/-a-case-of-non-cardiac-chest-pain-caused-by-esophageal-motility-disorder-observed-on-esophageal-high-resolution-manometry
#20
Kazumasa Muta, Eikichi Ihara, Yusuke Kitagawa, Shohei Hamada, Keita Fukaura, Tsutomu Iwasa, Akira Aso, Haruei Ogino, Kazuhiko Nakamura, Yoshihiro Ogawa
A 20-year-old man was referred to our hospital with dysphagia and chest pain. Heart disease was denied. No abnormality was observed in upper esophagogastroduodenoscopy and fluoroscopy;furthermore, no gastric acid-related symptoms were observed on combined esophageal multichannel intraluminal impedance and pH monitoring. Esophageal high-resolution manometry (HRM) performed by liquid swallow revealed normal peristalsis;however, HRM performed while the patient was taking solid meals showed abnormal contraction, and the patient simultaneously complained of chest pain...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
keyword
keyword
98181
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"