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https://www.readbyqxmd.com/read/29456774/gastric-aspiration-and-its-role-in-airway-inflammation
#1
REVIEW
E B Hunt, A Sullivan, J Galvin, J MacSharry, D M Murphy
Gastro-Oesophageal Reflux (GOR) has been associated with chronic airway diseases while the passage of foreign matter into airways and lungs through aspiration has the potential to initiate a wide spectrum of pulmonary disorders. The clinical syndrome resulting from such aspiration will depend both on the quantity and nature of the aspirate as well as the individual host response. Aspiration of gastric fluids may cause damage to airway epithelium, not only because acidity is toxic to bronchial epithelial cells but also due to the effect of digestive enzymes such as pepsin and bile salts...
2018: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/29456176/comment-on-acid-and-nonacid-gastroesophageal-reflux-after-single-anastomosis-gastric-bypass-an-objective-assessment-using-24-hour-multichannel-intraluminal-impedance-ph-metry
#2
EDITORIAL
Kenneth B Jones
No abstract text is available yet for this article.
January 31, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29455967/gastroprotective-activity-of-polysaccharide-from-hericium-erinaceus-against-ethanol-induced-gastric-mucosal-lesion-and-pylorus-ligation-induced-gastric-ulcer-and-its-antioxidant-activities
#3
Xiao-Yin Wang, Jun-Yi Yin, Ming-Ming Zhao, Shi-Yu Liu, Shao-Ping Nie, Ming-Yong Xie
The gastroprotective activity of Hericium erinaceus polysaccharide was investigated in rats. The antioxidant activities were also evaluated. Pre-treatment of polysaccharide could reduce ethanol-induced gastric mucosal lesion and pylorus ligation-induced gastric ulcer. The polysaccharide exhibited scavenging activities of 1, 1-diphenyl-2-picryl-hydrozyl and hydroxyl radicals, and ferrous ion-chelating ability. In the pylorus ligation-induced model, gastric secretions (volume of gastric juice, gastric acid, pepsin and mucus) of ulcer rats administrated with polysaccharide were regulated...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29455533/effect-of-dietary-protein-level-on-the-expression-of-proteins-in-the-gastrointestinal-tract-of-young-pigs
#4
Xianyong Ma, Xianyong Ma, Zhimei Tian, Dun Deng, Yiyan Cui, Yueqin Qiu
The objective of this research is to investigate the effect of protein level on proteins expression in the gastrointestinal tract of young pigs. Eighteen piglets (Duroc×Landrace×Yorkshire) were weaned at 28 days of age and randomly assigned to 3 diets with 20%, 17%, and 14% CP level and four essential AA: Lys, Met, Thr and Trp in three diets meet the requirements of weaned piglets. The experimental period lasts 45d. RESULTS: Compared with the control (20% CP level), the average daily feed intake, the average daily gain and gain feed ratio of the 17% CP group did not decrease (P > 0...
February 17, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29453635/monitoring-of-erlotinib-in-pancreatic-cancer-patients-during-long-time-administration-and-comparison-to-a-physiologically-based-pharmacokinetic-model
#5
Andrea Gruber, Martin Czejka, Philipp Buchner, Marie Kitzmueller, Nairi Kirchbaumer Baroian, Christian Dittrich, Azra Sahmanovic Hrgovcic
PURPOSE: In this study, a therapeutic drug monitoring (TDM) of erlotinib in pancreatic cancer patients was performed over 50 weeks to reveal possible alterations in erlotinib plasma concentrations. Additionally, a physiologically based pharmacokinetic (PBPK) model was created to assess such variations in silico. METHODS: Patients with advanced pancreatic cancer received a chemotherapeutic combination of 100 mg erlotinib q.d., 500-900 mg capecitabine b.d. and 5 mg/kg bevacizumab q...
February 16, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29453461/roux-en-y-gastric-bypass-and-sleeve-gastrectomy-induces-specific-shifts-of-the-gut-microbiota-without-altering-the-metabolism-of-bile-acids-in-the-intestinal-lumen
#6
Henri Duboc, Caroline Chong Nguyen, Jean-Baptiste Cavin, Lara Ribeiro-Parenti, Anne-Charlotte Jarry, Dominique Rainteau, Lydie Humbert, Benoit Coffin, Maude Le Gall, André Bado, Harry Sokol
Some shifts in the gut microbiota composition and its metabolic fingerprints have been associated to Sleeve gastrectomy (SG) and Roux-en-Y Gastric Bypass (RYGB). So far, plasma bile acids have been associated with post-operative glucose improvement and weight loss, but nothing is known about their metabolism in the gut lumen. As bile acids are physiologically transformed by the microbiota into various species, the aim of this work was to study how SG and RYGB-associated dysbiosis impact the bioconversion of bile acids in the intestinal lumen...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29452760/reliable-procedure-of-polyglycolic-acid-sheet-delivery-and-placement-on-gastric-artificial-floor-application-of-wafer-paper-and-thread
#7
Nobuya Kobayashi, Hirohito Mori, Hideki Kobara, Tsutomu Masaki
No abstract text is available yet for this article.
February 13, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29450805/ph-responsive-cap-co-poly-methacrylic-acid-based-hydrogel-as-an-efficient-platform-for-controlled-gastrointestinal-delivery-fabrication-characterization-in-vitro-and-in-vivo-toxicity-evaluation
#8
Syed Ahmed Shah, Muhammad Sohail, Muhammad Usman Minhas, Nisar-Ur-Rehman, Shahzeb Khan, Zahid Hussain, Mudassir, Arshad Mahmood, Mubeen Kousar, Asif Mahmood
Cellulose acetate phthalate-based pH-responsive hydrogel was synthesized for fabrication of polymeric matrix tablets for gastro-protective delivery of loxoprofen sodium. Cellulose acetate phthalate (CAP) was cross-linked with methacrylic acid (MAA) using free radical polymerization technique. Fourier transform infrared (FTIR) spectra confirmed the formation of cross-linked structure of CAP-co-poly(methacrylic acid). Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) confirmed the thermal stability of polymeric networks, and scanning electron microscopy (SEM) and energy-dispersive X-ray spectrum (EDS) images unveiled that the prepared formulations were porous in nature and thus the developed formulations had shown better diffusibility...
February 15, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29447920/over-expression-of-bcat1-is-a-prognostic-marker-in-gastric-cancer
#9
Yuan Xu, Weiming Yu, Taotao Yang, Miaozun Zhang, Chao Liang, Xianlei Cai, Qinshu Shao
As one form of branched chain amino-acid transaminase(BCAT) enzymes, It has been found that up-regulation of BCAT1 is associated with poor prognosis in numerous types of tumors, but studies on the role of BCAT1 expression in gastric cancer(GC) are rare. The aim of this study was to detect BCAT1 expression in (GC) and to analyze its association with prognosis of GC patients. Microarray experiments were performed on the Affymetrix U133 plus 2.0 GeneChip Array. The protein and mRNA levels of BCAT1 were validated by immunohistochemistry (IHC) and Real-Time quantitative PCR (RT-qPCR) in GC tissues and adjacent noncancerous tissues (ANCT)...
February 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29443403/proceedings-of-the-2017-aspen-research-workshop-gastric-bypass-role-of-the-gut
#10
REVIEW
Ajay Kumar Jain, Carel W le Roux, Puneet Puri, Ali Tavakkoli, Nana Gletsu-Miller, Blandine Laferrère, Richard Kellermayer, John K DiBaise, Robert G Martindale, Bruce M Wolfe
The goal of the National Institutes of Health-funded American Society for Parenteral and Enteral Nutrition 2017 research workshop (RW) "Gastric Bypass: Role of the Gut" was to focus on the exciting research evaluating gut-derived signals in modulating outcomes after bariatric surgery. Although gastric bypass surgery has undoubted positive effects, the mechanistic basis of improved outcomes cannot be solely explained by caloric restriction. Emerging data suggest that bile acid metabolic pathways, luminal contents, energy balance, gut mucosal integrity, as well as the gut microbiota are significantly modulated after bariatric surgery and may be responsible for the variable outcomes, each of which was rigorously evaluated...
February 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29443099/detection-of-a-cdh1-rare-transcript-variant-in-fresh-frozen-gastric-cancer-tissues-by-chip-based-digital-pcr
#11
Chiara Molinari, Raefa Abou Khouzam, Samanta Salvi, Tania Rossi, Guglielmina Nadia Ranzani, Daniele Calistri
CDH1a, a non-canonical transcript of the CDH1 gene, has been found to be expressed in some gastric cancer (GC) cell lines, whereas it is absent in normal gastric mucosa. Recently, we detected CDH1a transcript variant in fresh-frozen tumor tissues obtained from patients with GC. The expression of this variant in tissue samples was investigated by the chip-based digital PCR (dPCR) approach presented here. dPCR offers the potential for an accurate, robust, and highly sensitive measurement of nucleic acids and is increasingly utilized for many applications in different fields...
February 5, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29442451/application-of-an-anionic-polymer-in-the-formulation-of-floating-tablets-containing-an-alkaline-model-drug
#12
Dorota Wójcik-Pastuszka, Iwona Golonka, Andrzej Drys, Jobst B Mielck, Maria Twarda, Witold Musiał
BACKGROUND: Gastric residence time is the key factor affecting the bioavailability of active pharmaceutical ingredients absorbed mainly through the gastric mucous membrane and influencing the local activity of some drugs. OBJECTIVES: The aim of this study was the development of a new composition of non-effervescent floating tablets and the evaluation of the effect of an anionic polymer and compressive force on the floating properties and release characteristics of tablets containing a model alkaline drug, chlorhexidine (CHX)...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442019/gastroresistant-gelatin-films-prepared-by-addition-of-cellulose-acetate-phthalate
#13
B Maciejewski, W Weitschies, F Schneider, M Sznitowska
Gastroresistant capsules are obtained mostly by using modified-release fill in hard capsules, or by coating the gelatin shell with acid-resistant polymers. Modification of the material used at the stage when the capsule shell is produced would reduce the complexity and cost of introducing new products to the market. Gastroresistant gelatin films were obtained by using commercial cellulose acetate phthalate (aqueous dispersion Aquacoat® CPD). Only films casted from non-alkalized mixtures showed no visible disintegration at pH from 1...
June 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441735/the-role-of-mmu-mir-155-5p-nf-%C3%AE%C2%BAb-signaling-in-the-education-of-bone-marrow-derived-mesenchymal-stem-cells-by-gastric-cancer-cells
#14
Mei Wang, Fang Yang, Rong Qiu, Mengchu Zhu, Huiling Zhang, Wenrong Xu, Bo Shen, Wei Zhu
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are important precursors of tumor stromal cells. Previously, we have demonstrated that miR-155-5p inhibition directly induced transition of BM-MSCs into gastric cancer-associated MSCs. Whether miR-155-5p is involved in the education of BM-MSCs by gastric cancer cells has not been established. Murine BM-MSCs (mMSCs) were isolated and grown in conditioned medium derived from gastric cancer cell line MFC (MFC-CM). The tumor-promoting phenotype and function of mMSCs were detected by immunofluorescence staining, quantitative reverse transcription-polymerase chain reaction (qRT-PCR), cell colony formation assay, transwell migration, and invasion assays...
February 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29438780/modulation-of-central-endocannabinoid-system-results-in-gastric-mucosal-protection-in-the-rat
#15
V E Tóth, Á Fehér, J Németh, I Gyertyán, Z S Zádori, K Gyires
Previous findings showed that inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), degrading enzymes of anandamide (2-AEA) and 2-arachidonoylglycerol (2-AG), reduced the nonsteroidal anti-inflammatory drug-induced gastric lesions. The present study aimed to investigate: i./whether central or peripheral mechanism play a major role in the gastroprotective effect of inhibitors of FAAH, MAGL and AEA uptake, ii./which peripheral mechanism(s) may play a role in mucosal protective effect of FAAH, MAGL and uptake inhibitors...
February 10, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29435755/surgical-management-of-gastroesophageal-reflux-disease-in-patients-with-systemic-sclerosis
#16
Jingliang Yan, Andrew T Strong, Gautam Sharma, Scott Gabbard, Prashanti Thota, John Rodriguez, Matthew Kroh
BACKGROUND: Systemic sclerosis (scleroderma) is frequently associated with both gastroesophageal reflux disease (GERD) and simultaneous esophageal dysmotility. Anti-reflux procedures in this patient population must account for the existing physiology of each patient and likely disease progression. We aim to compare perioperative and intermediate outcomes of fundoplication versus gastric bypass for the treatment of GERD. METHODS: After IRB approval, patients with systemic sclerosis undergoing fundoplication or gastric bypass for the treatment of GERD from 2004 to 2016 were identified...
February 12, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29434845/all-trans-retinoic-acid-inhibits-the-proliferation-of-sgc7901-cells-by-regulating-caveolin-1-localization-via-the-erk-mapk-signaling-pathway
#17
Sumei Zhang, Rui Shi, Shaolong Chen, Xiang Wei, Qing Zhou, Yuan Wang
Caveolin-1 is a scaffold protein of caveolae in the mucosa of the gastrointestinal tract and acts as a tumor modulator by interacting with cell adhesion molecules and signaling receptors. Caveolin-1 stabilizes cell-cell and cell-matrix contacts and is a hallmark of a number of different types of human cancer, including gastric cancer. All-trans retinoic acid (ATRA), a derivative of vitamin A, has been demonstrated to exhibit tumor inhibitory effects in acute leukemia and certain types of solid tumor. In the present study, treatment with ATRA was demonstrated to inhibit the proliferation of gastric cancer cell line SGC7901, in a time- and dose-dependent manner...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433230/in-vitro-digestion-behavior-of-water-in-oil-in-water-emulsions-with-gelled-oil-water-inner-phases
#18
Jonathan Andrade, Amanda J Wright, Milena Corredig
Double emulsions may be able to protect and release in a controlled manner bioactive compounds during digestion of food matrices. It was hypothesized that the physical state and solid content in the inner phases of water-in-oil-in-water (W1/O/W2) emulsions may affect the overall stability and the release behavior of bioactives during in vitro digestion. Therefore, hydrophobic (phytosterols or Vitamin D3) and hydrophilic (Vitamin B12) molecules were incorporated in double emulsions prepared either with a liquid (soybean oil - SO) or oil-fat gel (soybean oil+trimyristin - STO) lipid phase and liquid internal aqueous phase...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29433221/colonic-fermentation-of-polyphenolics-from-sea-buckthorn-hippophae-rhamnoides-berries-assessment-of-effects-on-microbial-diversity-by-principal-component-analysis
#19
Sampan Attri, Kavita Sharma, Pinky Raigond, Gunjan Goel
The present study investigates the stability of polyphenolic in Sea buckthorn berries juice (SBJ) during different phases of digestion and its effect on colonic microbial diversity. At each stage, the Total polyphenolic content (TPC), Total antioxidant activity (TAA) and polyphenolic profile was determined. A 1.64 and 2.20 folds increase in TPC with 4.88 and 9.61 folds increase in TAA were observed during gastric and small intestine digestion (p<0.05) with the release of quercetin from food matrix. The digestion resulted in deformation of intact crystalline structure as indicated by scanning electron micrographs...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29430842/glucagon-like-peptide-1-glp-1-based-therapeutics-current-status-and-future-opportunities-beyond-type-2-diabetes
#20
Jia Ying Cheang, Peter Michael Moyle
Glucagon-like peptide-1 (GLP-1) is secreted by intestinal L-cells following food intake, and plays an important role in glucose homeostasis due to its stimulation of glucose-dependent insulin secretion. Further, GLP-1 is also associated with protective effects on pancreatic β-cells and the cardiovascular system, reduced appetite, and weight loss, making GLP-1 derivatives an exciting treatment for type 2 diabetes and obesity. Despite these benefits, wild-type GLP-1 exhibits a short circulation time, due to its poor metabolic stability and rapid renal clearance, and needs to be administered by injection, making it a poor therapeutic agent...
February 11, 2018: ChemMedChem
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