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Throat Cancer

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https://www.readbyqxmd.com/read/29756245/age-related-differences-in-health-related-quality-of-life-among-thyroid-cancer-survivors-compared-with-a-normative-sample-results-from-the-profiles-registry
#1
Floortje Mols, Dounya Schoormans, Jan W A Smit, Romana T Netea-Maier, Thera P Links, Winette T A van der Graaf, Olga Husson
BACKGROUND: The purpose of this study was to compare general health-related quality of life (HR-QOL) of thyroid cancer survivors with a normative sample stratified by age at diagnosis (adolescents and young adults 18-35 years; middle-aged adults 36-64 years; elderly 65-84 years), and to compare general HR-QOL and disease-specific symptoms among adolescents and young adults, middle-aged adults, and elderly thyroid cancer survivors in an exploratory population-based cross-sectional study...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29748768/microvessel-density-in-head-and-neck-squamous-cell-carcinoma
#2
Tomasz Szafarowski, Janusz Sierdzinski, Miroslaw J Szczepanski, Theresa L Whiteside, Nils Ludwig, Antoni Krzeski
PURPOSE: Microvessel density (MVD) corresponds to the intensity of neo-angiogenesis. MVD assessments are based on the expression levels of the vascular endothelium markers such as, e.g., CD34 or CD105. The goal of this study was to assess MVD among patients with head and neck squamous cell carcinoma (HNSCC), and to evaluate the predictive value of MVD in head and neck cancers. METHODS: The study included 49 patients treated for HNSCC and 11 patients with dysplasia of the upper respiratory tract epithelium...
May 10, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29725412/locally-advanced-laryngeal-cancer-total-laryngectomy-or-primary-non-surgical-treatment
#3
Aleš Čoček, Miloslav Ambruš, Alena Dohnalová, Martin Chovanec, Martina Kubecová, Kateřina Licková
Between January 1997 and December 2013, the Charles University 3rd Medical School and Royal Vinohrady Teaching Hospital Ear, Nose and Throat oncology team treated 185 patients with advanced laryngeal cancer, which, from a surgical perspective, required a total laryngectomy. Overall, ~70% of these patients (n=129) underwent conventional treatment (i.e., total laryngectomy with post-operative radiotherapy), and ~30% (n=56) were treated with larynx preservation protocols (including primary radiotherapy, neoadjuvant chemotherapy followed by radiotherapy or chemoradiotherapy, or primary chemoradiotherapy)...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29719797/convex-probe-endobronchial-ultrasound-for-thyroid-biopsy-a-new-hybrid-method
#4
Konstantinos Sapalidis, Christoforos Kosmidis, Stella Laskou, Paul Zarogoulidis, Ilias Karapantzos, Chrysa Karapantzou, Anastasios Kallianos, Wolfgang Hohenforst-Schmidt, Michael Karanikas, Vasilis Thomaidis, Haidong Huang, Chong Bai, Isaak Kesisoglou
Nowadays we use novel diagnostic equipment for lung cancer. Bronchoscopy was the tip of the arrow for diagnosis, however; ultrasound systems have brought a revolution. We have the radial-endobronchial ultrasound for peripheral lesions and the convex probe endobronchial ultrasound for central lesions. Ultrasound endoscopic systems can be used for the diagnosis of any lesion that can be approached from the airways. In the current manuscript we will present two methods for the biopsy of thyroid gland. The first method is using anesthisiological tools and the second tools from the ear, nose and throat department...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29675996/streptococcus-endopeptidases-promote-hpv-infection-in-vitro
#5
Sylvia I Pavlova, Reid V Wilkening, Michael J Federle, Yu Lu, Joel Schwartz, Lin Tao
Both cervical and throat cancers are associated with human papillomavirus (HPV). HPV infection requires cleavage of the minor capsid protein L2 by furin. While furin is present in the vaginal epithelium, it is absent in oral epithelial basal cells where HPV infection occurs. The objective of this study was to investigate whether common oral bacteria express furin-like peptidases. By screening strains representing 12 oral Streptococcus and Enterococcus species, we identified that eight Streptococcus strains displayed high levels of furin-like peptidase activity, with S...
April 19, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29509539/cervical-exenteration-guidelines-and-surgical-technique-principles
#6
Constantin Ciuce, Răzvan Scurtu, Cătălin Ciuce, Raluca Apostu, Horea Bocşe, George Dindelegan
Introduction: Neoplastic invasion of the structures of the cervical region originating from a malignant tumour developed in one of the viscera of the throat may benefit from cervical exenteration. Defined as resection of the hypopharynx, cervical oesophagus, larynx and cervical trachea, exenteration has limited indications and is mandatorily accompanied by digestive tube reconstruction. The aim of this article is to highlight the indication, surgical strategy and important surgical stages illustrated by images from personal professional experience...
January 2018: Chirurgia
https://www.readbyqxmd.com/read/29477448/effect-of-lung-deflation-with-indacaterol-plus-glycopyrronium-on-ventricular-filling-in-patients-with-hyperinflation-and-copd-claim-a-double-blind-randomised-crossover-placebo-controlled-single-centre-trial
#7
Jens M Hohlfeld, Jens Vogel-Claussen, Heike Biller, Dominik Berliner, Korbinian Berschneider, Hanns-Christian Tillmann, Simone Hiltl, Johann Bauersachs, Tobias Welte
BACKGROUND: Pulmonary hyperinflation in chronic obstructive pulmonary disease (COPD) is associated with reduced biventricular end-diastolic volumes and increased morbidity and mortality. The combination of a long-acting β agonist (LABA) and a muscarinic antagonist (LAMA) is more effective in reducing hyperinflation than LABA-inhaled corticosteroid combination therapy but whether dual bronchodilation improves cardiac function is unknown. METHODS: We did a double-blind, randomised, two-period crossover, placebo-controlled, single-centre study (CLAIM) at the Fraunhofer Institute of Toxicology and Experimental Medicine (Hannover, Germany), a specialty clinic...
May 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29467876/comparison-of-the-safety-of-the-application-of-painless-gastroscopy-and-ordinary-gastroscopy-in-chronic-hypertension-patients-combined-with-early-gastric-cancer
#8
Fangli Men, Lianmin Wei, Bing Liu, Fengting Wu, Jingyu Liu, Ni Guo, Qing Niu
The aim of the present study was to compare the safety of the application of painless gastroscopy and ordinary gastroscopy for chronic hypertension patients combined with early gastric cancer. A total of 123 patients with early gastric cancer were selected at the Dongying People's Hospital from June, 2014 to August, 2016. The patients were randomly divided into the painless (n=63) and ordinary (n=60) gastroscopy groups. Proper pretreatment was performed according to whether anesthesia was performed or not. Arterial pressure, heart rate, and blood oxygen saturation were detected and compared before anesthesia, when gastroscope passed through the esophageal entrance plane, and after recovery from anesthesia...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29427732/risk-of-oral-and-upper-gastrointestinal-cancers-in-persons-with-positive-results-from-a-fecal-immunochemical-test-in-a-colorectal-cancer-screening-program
#9
Manon van der Vlugt, Esmée J Grobbee, Patrick M Bossuyt, Amanda C R K Bos, Ernst J Kuipers, Iris Lansdorp-Vogelaar, Manon C W Spaander, Evelien Dekker
BACKGROUND & AIMS: European guidelines recommend screening for colorectal cancer (CRC) using the fecal immunochemical test (FIT), with follow-up colonoscopies for individuals with positive test results. However, more than half of participants with positive results from the FIT are not found to have advanced neoplasia in the colonoscopy examination. Fecal occult blood might also come from the upper gastrointestinal (GI) tract, so perhaps we should consider esophagogastroduodenoscopy (EGD), to detect upper GI cancers...
February 7, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29410452/occupational-exposure-to-polycyclic-aromatic-hydrocarbons-and-elevated-cancer-incidence-in-firefighters
#10
Anna A Stec, Kathryn E Dickens, Marielle Salden, Fiona E Hewitt, Damian P Watts, Philip E Houldsworth, Francis L Martin
Cancer incidence appears to be higher amongst firefighters compared to the general population. Given that many cancers have an environmental component, their occupational exposure to products of carbon combustion such as polycyclic aromatic hydrocarbons (PAHs) is of concern. This is the first UK study identifying firefighters exposure to PAH carcinogens. Wipe samples were collected from skin (jaw, neck, hands), personal protective equipment of firefighters, and work environment (offices, fire stations and engines) in two UK Fire and Rescue Service Stations...
February 6, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29385936/hippocrates-the-otolaryngologist-an-epidemiological-analysis-of-ear-throat-nose-diseases-in-the-corpus-hippocraticum
#11
Nadia Benmoussa, Kevin Hansen, Philippe Charlier
INTRODUCTION: Hippocrates, a Greek physician during the fifth century BC., is often considered the father of medicine. The Corpus Hippocraticum comprising of 58 volumes was attributed to him alone for a long time. Nowadays, it is considered that several authors contributed to its creation between 450 and 150 BC., so over a period of 300 years. The objective of our study was to develop a nosological classification of all passages treating head and neck diseases. MATERIAL AND METHODS: We read and analyzed all volumes of the Corpus Hippocraticum in French translation and extracted all passages dealing with oto-rhino-laryngological and maxillo-facial conditions (n = 65)...
March 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29354579/comparison-of-clinical-characteristics-between-patients-with-different-causes-of-vocal-cord-immobility
#12
Min-Hyun Kim, Junsoo Noh, Sung-Bom Pyun
Objective: To analyze the clinical characteristics between neurogenic and non-neurogenic cause of vocal cord immobility (VCI). Methods: The researchers retrospectively reviewed clinical data of patients who underwent laryngeal electromyography (LEMG). LEMG was performed in the bilateral cricothyroid and thyroarytenoid muscles. A total of 137 patients were enrolled from 2011 to 2016, and they were assigned to either the neurogenic or non-neurogenic VCI group, according to the LEMG results...
December 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29353657/randomized-double-blind-placebo-controlled-trial-of-shuanghua-baihe-tablets-to-prevent-oral-mucositis-in-patients-with-nasopharyngeal-cancer-undergoing-chemoradiation-therapy
#13
Baomin Zheng, Xiaodong Zhu, Mengzhong Liu, Zhenzhou Yang, Ling Yang, Jinyi Lang, Mei Shi, Gang Wu, Xia He, Xiaozhong Chen, Xuping Xi, Dan Zhao, Guangying Zhu
PURPOSE: Oral mucositis is a common unpreventable complication associated with chemoradiation therapy. Shuanghua Baihe tablets have been approved by the Chinese Food and Drug Administration for treating recurrent oral mucosa ulceration. This study assessed whether Shuanghua Baihe tablets could prevent oral mucositis during chemoradiation therapy for locally advanced nasopharyngeal carcinoma. METHODS AND MATERIALS: This multicenter, randomized, double-blind, placebo-controlled trial was conducted at 11 hospitals in China between January 22, 2014, and September 21, 2015...
February 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29235378/the-hexane-fraction-of-bursera-microphylla-a-gray-induces-p21-mediated-anti-proliferative-and-pro-apoptotic-effects-in-human-cancer-derived-cell-lines
#14
Sabrina Adorisio, Alessandra Fierabracci, Giulia Gigliarelli, Isabella Muscari, Lorenza Cannarile, Anna Marina Liberati, Maria Carla Marcotullio, Carlo Riccardi, Massimo Curini, Ramon Enrique Robles Zepeda, Domenico V Delfino
Bursera microphylla (BM), one of the common elephant trees, is widely distributed in the Sonoran Desert in Mexico. The Seri ethnic group in the Sonoran Desert uses BM as an anti-inflammatory and painkiller drug for the treatment of sore throat, herpes labialis, abscessed tooth, and wound healing. Dried stems and leaves of BM are used in a tea to relieve painful urination and to stimulate bronchial secretion. Furthermore, BM is used for fighting venereal diseases. To investigate the effects of the hexane fraction of resin methanol extract (BM-H) on cell growth, the acute myeloid cell line (OCI-AML3) was treated with 250, 25, or 2...
March 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29209970/haze-and-health-impacts-in-asean-countries-a-systematic-review
#15
Logaraj Ramakreshnan, Nasrin Aghamohammadi, Chng Saun Fong, Awang Bulgiba, Rafdzah Ahmad Zaki, Li Ping Wong, Nik Meriam Sulaiman
Seasonal haze episodes and the associated inimical health impacts have become a regular crisis among the ASEAN countries. Even though many emerging experimental and epidemiological studies have documented the plausible health effects of the predominating toxic pollutants of haze, the consistency among the reported findings by these studies is poorly understood. By addressing such gap, this review aimed to critically highlight the evidence of physical and psychological health impacts of haze from the available literature in ASEAN countries...
January 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29206898/somatic-mutation-footprinting-reveals-a-unique-tetranucleotide-signature-associated-with-intron-exon-boundaries-in-lung-cancer
#16
Samuel Wormald, Anita Lerch, Dmitri Mouradov, Liam O'Connor
Cigarette smoke comprises a large number of carcinogenic substances that can increase DNA mutation load in epithelial cells of the mouth, throat and lungs. While a strong C:A substitution preference is abundant in tobacco-related cancer genomes, detection of complex or less abundant somatic mutation signatures may be confounded by the heterogeneity of carcinogens present in smoke. Trinucleotide signatures are defined for a variety of somatic mutation processes, yet the extent to which this configuration optimally defines and discriminates between mutational processes is not clear...
February 9, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29199660/a-study-of-changes-in-the-oral-fungal-flora-of-patients-on-radiotherapy-for-head-and-neck-malignancies-and-their-correlation-with-funguria-and-fungemia
#17
S Raj, D Sharma, P Mate, M R Capoor, K T Bhowmik
BACKGROUND: Patients of head and neck malignancies often develop oral mucositis and invite various pathogens to colonize over it. OBJECTIVES: The objective of this study is to identify the fungi isolated from patients undergoing radiotherapy (RT) for head and neck cancer, to determine the antifungal susceptibility of these isolates and to determine the time and week of fungal colonization. PATIENTS AND METHODS: Three specimens (throat, urine, and blood) were collected from each of the head and neck cancer patients, who were advised RT...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29183262/globus-symptoms-in-patients-undergoing-thyroidectomy-relationships-with-psychogenic-factors-thyroid-disease-and-surgical-procedure
#18
Chisato Tomoda, Kiminori Sugino, Tomoaki Tanaka, Yuna Ogimi, Chie Masaki, Junko Akaishi, Kiyomi Y Hames, Akifumi Suzuki, Kenichi Matsuzu, Takashi Uruno, Keiko Ohkuwa, Wataru Kitagawa, Mitsuji Nagahama, Koichi Ito
BACKGROUND: The number of patients who need thyroid surgery has increased worldwide in recent decades. Patients with thyroid disease experience globus pharyngeus as a result of direct compression and edema of the surrounding organs. Thyroid surgery is needed to improve these symptoms or as treatment for thyroid cancer. After thyroid surgery, globus symptoms may become worse and may affect the daily life of the patient for a long time. Psychogenic problems have also been thought to cause the globus sensation...
January 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29171050/contemplating-resectability
#19
Andrew G Shuman
Suzie loves to talk. A successful mid-thirties businesswoman, she is a self-described social butterfly-which made her diagnosis of tongue cancer even more devastating. She came to the clinic complaining of a lump in her throat, which in most young healthy people turns out to be benign and easily treated. But not for Suzie, who had a very rare salivary tumor arising in the back of her tongue. Its slow growth was both a blessing and a curse; such tumors do not kill people quickly, but they typically require surgery...
November 2017: Hastings Center Report
https://www.readbyqxmd.com/read/29130386/searching-for-god-illness-related-mortality-threats-and-religious-search-volume-in-google-in-16-nations
#20
Brett W Pelham, Mitsuru Shimizu, Jamie Arndt, Mauricio Carvallo, Sheldon Solomon, Jeff Greenberg
We tested predictions about religiosity and terror management processes in 16 nations. Specifically, we examined weekly variation in Google search volume in each nation for 12 years (all weeks for which data were available). In all 16 nations, higher than usual weekly Google search volume for life-threatening illnesses (cancer, diabetes, and hypertension) predicted increases in search volume for religious content (e.g., God, Jesus, prayer) in the following week. This effect held up after controlling for (a) recent past and annual variation in religious search volume, (b) increases in search volume associated with religious holidays, and (c) variation in searches for a non-life-threatening illness ("sore throat")...
March 2018: Personality & Social Psychology Bulletin
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