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https://www.readbyqxmd.com/read/28914009/luminescent-diagnostics-of-skin-defects-in-the-near-infrared-range
#1
Yuriy V Alekseev, Valentina D Rumyantseva, Anastasiya S Gorshkova, Anastasiya E Shchelkunova, Igor P Shilov, Andrey V Ivanov
Photodynamic therapy becomes a widely spread method due to cancer growth in the world. However, to detect tumors at early stages, it is necessary to carry out diagnostic measures in a timely manner. Our aim was to test the developed pharmaceutical composition, which can be used for external application in early fluorescent diagnostics even in the absence of visual changes, as well as for therapy effectiveness control. Pharmacokinetic studies on laboratory animals and volunteers were carried out. The results have shown that the dipotassium salt of Yb3+-dimethoxyhematoporphyrin IX, which is highly soluble in water and stable in storage, is a promising marker for earlier diagnostics of tumors and can be used in dermatology, dentistry, gynecology, cosmetology, ear, nose, and throat diseases, veterinary, and in other areas of medicine...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28888224/long-term-patient-reported-outcomes-following-radiation-therapy-for-oropharyngeal-cancer-cross-sectional-assessment-of-a-prospective-symptom-survey-in-patients-%C3%A2-65%C3%A2-years-old
#2
Salman A Eraj, Mona K Jomaa, Crosby D Rock, Abdallah S R Mohamed, Blaine D Smith, Joshua B Smith, Theodora Browne, Luke C Cooksey, Bowman Williams, Brandi Temple, Kathryn E Preston, Jeremy M Aymar, Neil D Gross, Randal S Weber, Amy C Hessel, Renata Ferrarotto, Jack Phan, Erich M Sturgis, Ehab Y Hanna, Steven J Frank, William H Morrison, Ryan P Goepfert, Stephen Y Lai, David I Rosenthal, Tito R Mendoza, Charles S Cleeland, Kate A Hutcheson, Clifton D Fuller, Adam S Garden, G Brandon Gunn
BACKGROUND: Given the potential for older patients to experience exaggerated toxicity and symptoms, this study was performed to characterize patient reported outcomes in older patients following definitive radiation therapy (RT) for oropharyngeal cancer (OPC). METHODS: Cancer-free head and neck cancer survivors (>6 months since treatment completion) were eligible for participation in a questionnaire-based study. Participants completed the MD Anderson Symptom Inventory-Head and Neck module (MDASI-HN)...
September 9, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28866829/an-investigation-of-the-prevalence-of-swallowing-difficulties-and-impact-on-quality-of-life-in-patients-with-advanced-lung-cancer
#3
Grainne C Brady, Justin W G Roe, Mary O' Brien, Annette Boaz, Clare Shaw
BACKGROUND: Dysphagia can occur in advanced lung cancer due to direct tumour invasion or nerve compression. Anti-cancer treatments and co-morbid conditions may also cause or compound dysphagic symptoms. Speech and language therapy (SLT), medical and surgical interventions are available to address dysphagic symptoms in patients with lung cancer, however, management options are not described in national guidelines. Given the potentially short prognoses for patients with lung cancer, the aim of care should be to reduce symptom burden and maximise quality of life (QOL)...
September 2, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28864539/signals-from-the-adipose-microenvironment-and-the-obesity-cancer-link-a-systematic-review
#4
REVIEW
Caroline Himbert, Mahmoud Delphan, Dominique Scherer, Laura W Bowers, Stephen Hursting, Cornelia M Ulrich
Obesity and its associated metabolic dysregulation are established risk factors for many cancers. However, the biologic mechanisms underlying this relationship remain incompletely understood. Given the rising rates of both obesity and cancer worldwide, and the challenges for many people to lose excess adipose tissue, a systematic approach to identify potential molecular and metabolic targets is needed to develop effective mechanism-based strategies for the prevention and control of obesity-driven cancer. Epidemiologic, clinical, and preclinical data suggest that within the growth-promoting, proinflammatory microenvironment accompanying obesity, crosstalk between adipose tissue (comprised of adipocytes, macrophages and other cells) and cancer-prone cells may occur via obesity-associated hormones, cytokines, and other mediators that have been linked to increased cancer risk and/or progression...
September 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28860813/low-versus-high-radioiodine-activity-for-ablation-of-the-thyroid-remnant-after-thyroidectomy-in-han-chinese-with-low-risk-differentiated-thyroid-cancer
#5
Rong-Bin Lv, Qing-Gang Wang, Chao Liu, Fang Liu, Qing Zhao, Jian-Guo Han, Dao-Ling Ren, Bin Liu, Cheng-Li Li
AIM: The aim of this study was to compare the efficacy and adverse effects of radioiodine ((131)I) therapy between two groups of patients with low-risk differentiated thyroid cancer (DTC) who received 30 mCi or 100 mCi radioiodine for ablation of the thyroid remnant after total thyroidectomy. METHODS: The study cohort was 173 patients, 85 of whom were given 30 mCi of radioiodine and the others were given 100 mCi of radioiodine. Follow-up involved neck ultrasonography, measurement of serum levels of thyroglobulin and whole-body scans to evaluate the response of radioiodine treatment...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28859039/clinical-profile-and-outcome-of-influenza-a-h1n1-in-pediatric-oncology-patients-during-the-2015-outbreak-a-single-center-experience-from-northern-india
#6
Nishant Verma, Vishal Pooniya, Archana Kumar
BACKGROUND: Owing to their immunocompromised status, childhood cancer patients on chemotherapy are at a greater risk for Influenza infection and its associated complications. There is limited data available on the clinical profile and outcome of Influenza A/H1N1 in this subset of patients. METHODS: A retrospective study was performed of Influenza A/H1N1 cases diagnosed between January 2015 to December 2015 in the in-patients of Pediatric Oncology unit of a tertiary care hospital from Northern India...
August 30, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28839865/transnasal-endoscopy-no-gagging-no-panic
#7
Clare Parker, Estratios Alexandridis, John Plevris, James O'Hara, Simon Panter
BACKGROUND: Transnasal endoscopy (TNE) is performed with an ultrathin scope via the nasal passages and is increasingly used. This review covers the technical characteristics, tolerability, safety and acceptability of TNE and also diagnostic accuracy, use as a screening tool and therapeutic applications. It includes practical advice from an ear, nose, throat (ENT) specialist to optimise TNE practice, identify ENT pathology and manage complications. METHODS: A Medline search was performed using the terms "transnasal", "ultrathin", "small calibre", "endoscopy", "EGD" to identify relevant literature...
October 2016: Frontline Gastroenterology
https://www.readbyqxmd.com/read/28815307/clinical-outcomes-after-local-anesthesia-with-monitored-anesthesia-care-during-thyroidectomy-and-selective-neck-dissection-a-randomized-study
#8
Min-Su Kim, Bo-Hae Kim, Young Eun Han, Dong Woo Nam, J Hun Hah
Although thyroidectomy under local anesthesia with monitored anesthesia care (LA-MAC) has been reported, reports of neck dissections beyond level VI under LA-MAC in patients with thyroid cancer are rare. We aimed to analyze clinical data and patient satisfaction levels during thyroidectomy and selective neck dissection by comparing LA-MAC and general anesthesia (GA) in adult patients undergoing these surgeries for thyroid cancer. The 60 enrolled patients comprised 50 patients that underwent thyroidectomy and 10 that underwent selective neck dissection; 30 underwent thyroidectomy (n = 25) or selective neck dissection (n = 5) under LA-MAC and 30 (matched patients) underwent thyroidectomy (n = 25) or selective neck dissection (n = 5) under GA...
August 16, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28801511/paraneoplastic-mucous-membrane-pemphigoid-with-ocular-and-laryngeal-involvement
#9
Silvia Lambiel, Pavel Dulguerov, Emmanuel Laffitte, Igor Leuchter
A 73-year-old woman was treated 8 years previously for synchronous breast and uterine neoplasms. She presented with a severe sore throat, odynophagia, dysphonia, dyspnoea, ocular irritation and weight loss over the last 3 months. Physical examination revealed ulcerations in the oral cavity, posterior pharyngeal wall and supraglottic larynx, nasal crusting, bilateral conjunctivitis and three cutaneous blisters. A diagnosis of anti-laminin 5 mucous membrane pemphigoid was retained, based on skin biopsy, direct immunofluorescence and immunoprecipitation...
August 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28762075/incidence-and-5-year-survival-rate-for-head-and-neck-cancers-in-grenada-compared-to-the-african-american-population-over-the-period-1991-2010
#10
Maira du Plessis, Robert Hage
Very little data exist on the incidence and burden of cancer in the individual Caribbean countries. Some data are available for larger areas, reported under a bigger geographical region; Latin America and the Caribbean, but many of the individual countries are not included. One of the main reasons is a lack of official cancer registries. Data are usually collected from hospital records or private physician records, and since it is not in an official registry, these data are not always accessible for inclusion in databases such as SEER and GLOBOCAN...
July 31, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28710395/alterations-of-microbiota-structure-in-the-larynx-relevant-to-laryngeal-carcinoma
#11
Hongli Gong, Yi Shi, Xiyan Xiao, Pengyu Cao, Chunping Wu, Lei Tao, Dongsheng Hou, Yuezhu Wang, Liang Zhou
The microbial communities that inhabit the laryngeal mucosa build stable microenvironments and have the potential to influence the health of the human throat. However, the associations between the microbiota structure and laryngeal carcinoma remain uncertain. Here, we explored this question by comparing the laryngeal microbiota structure in laryngeal cancer patients with that in control subjects with vocal cord polyps through high-throughput pyrosequencing. Overall, the genera Streptococcus, Fusobacterium, and Prevotella were prevalent bacterial populations in the laryngeal niche...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28682843/diffuse-thyroid-metastasis-from-lung-cancer-mimicking-thyroiditis-on-99mtc-pertechnetate-scintigraphy
#12
Rui Gao, Shan Gao, Jinteng Feng, Yuanbo Wang, Guangjian Zhang
Possible thyroiditis was suspected in a 56-year-old man who initially presented sore throat because laboratory examinations revealed decreased serum thyroid hormone and the Tc-pertechnetate scintigraphy showed no tracer uptake by the thyroid gland. However, subsequent examination demonstrated that the absence of pertechnetate activity in the thyroid was due to complete replacement of thyroid gland by the metastasis from lung adenocarcinoma, which was unknown at the initial presentation.
September 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28676593/the-relationship-between-food-insecurity-and-esophageal-and-gastric-cancers-a-case-control-study
#13
Milad Daneshi-Maskooni, Mahtab Badri-Fariman, Nahal Habibi, Ahmadreza Dorosty-Motlagh, Hashem Yavari, Arvin Kashani, Mostafa Hosseini
BACKGROUND: Food insecurity is defined as the limited or uncertain availability of enough food for permanent active and healthy life. Upper gastrointestinal (GI) cancers (esophagus and stomach) are one of five most common cancers in Iran. This study aimed to determine the association of food insecurity and upper GI cancers in newly diagnosed patients. STUDY DESIGN: Case-control study. METHODS: Overall, 120 patients with upper GI cancers as cases and 120 patients with orthopedic, ear-nose-throat (ENT), and neurologic diseases as controls were recruited from Imam Khomeini Hospital, Tehran, Iran in 2013...
June 14, 2017: Journal of Research in Health Sciences
https://www.readbyqxmd.com/read/28669164/application-of-the-weibull-distribution-with-a-non-constant-shape-parameter-for-identifying-risk-factors-in-pharyngeal-cancer-patients
#14
Haleh Aghamolaey, Ahmad Reza Baghestani, Farid Zayeri
Background: In its standard form, the parametric survival model assumes that the shape parameter is constant and the scaling parameter is not. This article focuses on how a model with a non-constant shape parameter could make differences in oncology studies and lead to more precise results. Materials and Methods: Online data for part of a large clinical trial conducted by the Radiation Oncology Group in the United States available online on UMass Amherst`s website were employed. The full study included patients with squamous cell carcinoma from fifteen sites in the mouth and throat, although only data on three sites in the oropharynx reported by the six largest institutions were considered here...
June 25, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28604802/serological-profiling-of-the-ebv-immune-response-in-chronic-fatigue-syndrome-using-a-peptide-microarray
#15
Madlen Loebel, Maren Eckey, Franziska Sotzny, Elisabeth Hahn, Sandra Bauer, Patricia Grabowski, Johannes Zerweck, Pavlo Holenya, Leif G Hanitsch, Kirsten Wittke, Peter Borchmann, Jens-Ulrich Rüffer, Falk Hiepe, Klemens Ruprecht, Uta Behrends, Carola Meindl, Hans-Dieter Volk, Ulf Reimer, Carmen Scheibenbogen
BACKGROUND: Epstein-Barr-Virus (EBV) plays an important role as trigger or cofactor for various autoimmune diseases. In a subset of patients with Chronic Fatigue Syndrome (CFS) disease starts with infectious mononucleosis as late primary EBV-infection, whereby altered levels of EBV-specific antibodies can be observed in another subset of patients. METHODS: We performed a comprehensive mapping of the IgG response against EBV comparing 50 healthy controls with 92 CFS patients using a microarray platform...
2017: PloS One
https://www.readbyqxmd.com/read/28558632/thyroglobulin-determination-in-fine-needle-aspiration-biopsy-washout-of-suspicious-lymph-nodes-in-thyroid-carcinoma-follow-up
#16
Gaetano Achille, Vito Michele Garrisi, Edoardo Guastamacchia, Vito Angelo Giagulli, Antonio Tufaro, Vito Cafagna, Stefania Zizzi, Marilena Centrone, Giovanni Simone, Ines Abbate, Vincenzo Triggiani
BACKGROUND: Differentiated thyroid carcinomas (DTCs) account for about 1% of all human malignancies. Cervical lymph nodes metastases and recurrences in the thyroid bed frequently occur. Furthermore, about 10-15% of patients develop distant metastases. Therefore, patients must undergo life-long follow-up. OBJECTIVE: The aim of this study was to evaluate the usefulness of Thyroglobulin measurement in FNAB washout (FNAB-Tg) in the detection of local metastasis in patients affected by or evaluated for thyroid cancer...
May 30, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28539734/honey-and-health-a-review-of-recent-clinical-research
#17
REVIEW
Saeed Samarghandian, Tahereh Farkhondeh, Fariborz Samini
Honey is one of the most appreciated and valued natural products introduced to humankind since ancient times. Honey is used not only as a nutritional product but also in health described in traditional medicine and as an alternative treatment for clinical conditions ranging from wound healing to cancer treatment. The aim of this review is to emphasize the ability of honey and its multitude in medicinal aspects. Traditionally, honey is used in the treatment of eye diseases, bronchial asthma, throat infections, tuberculosis, thirst, hiccups, fatigue, dizziness, hepatitis, constipation, worm infestation, piles, eczema, healing of ulcers, and wounds and used as a nutritious supplement...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28528686/hpv-entry-into-cells
#18
REVIEW
Pinar Aksoy, Elinor Y Gottschalk, Patricio I Meneses
Human papillomavirus (HPV) is a sexually transmitted virus responsible for the development of cervical cancer, anal cancer, head and throat cancers, as well as genital area warts. A major focus of current HPV research is on preventing the virus from entering a cell and transferring its genetic material to the nucleus, thus potentially preventing the development of cancer. Although the available HPV vaccines are extremely successful, approximately 15 additional cancer-causing HPVs have been identified that the vaccines do not protect against...
April 2017: Mutat Res Rev Mutat Res
https://www.readbyqxmd.com/read/28492935/employer-reactions-to-adductor-spasmodic-dysphonia-exploring-the-influence-of-symptom-severity-and-disclosure-of-diagnosis-during-a-simulated-telephone-interview
#19
Derek D Isetti, Carolyn R Baylor, Michael I Burns, Tanya L Eadie
Purpose: The purpose of this study was to determine the influence of symptom severity and disclosure of adductor spasmodic dysphonia (ADSD) on the perceptions of human resource personnel members (HRPs) during a simulated phone interview. Method: One female speaker with ADSD was recorded reading an interview script at two time points: (a) pre-BOTOX injection (severe), and (b) post-BOTOX injection (mild). Thirty-two HRPs evaluated the recording in one of the two conditions via a qualitative structured interview...
May 17, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28356689/an-epidemiological-survey-in-hospital-setup-in-lucknow-district-a-cross-sectional-study
#20
Uma Shanker Pal, Mayank Singh, Lakshya Kumar, Pankaj Verma, R K Singh, Shailendra Kumar, G G Agarwal, Akash Asthana
INTRODUCTION: Oral cancer is the sixth most common form of cancer reported globally which includes lip, tongue, mouth, and throat. Developing countries face several challenges to identify and remove potential risk factors. Chewing tobacco/pan masala is considered to be the most potential risk factor for oral precancerous lesions and oral cancer. OBJECTIVE: To study the clinical-epidemiological profile of oral cancer cases and potential risk factor associated with it...
July 2016: National Journal of Maxillofacial Surgery
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