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Throat Cancer

Constantin Ciuce, Răzvan Scurtu, Cătălin Ciuce, Raluca Apostu, Horea Bocşe, George Dindelegan
Introduction: Neoplastic invasion of the structures of the cervical region originating from a malignant tumour developed in one of the viscera of the throat may benefit from cervical exenteration. Defined as resection of the hypopharynx, cervical oesophagus, larynx and cervical trachea, exenteration has limited indications and is mandatorily accompanied by digestive tube reconstruction. The aim of this article is to highlight the indication, surgical strategy and important surgical stages illustrated by images from personal professional experience...
January 2018: Chirurgia
Jens M Hohlfeld, Jens Vogel-Claussen, Heike Biller, Dominik Berliner, Korbinian Berschneider, Hanns-Christian Tillmann, Simone Hiltl, Johann Bauersachs, Tobias Welte
BACKGROUND: Pulmonary hyperinflation in chronic obstructive pulmonary disease (COPD) is associated with reduced biventricular end-diastolic volumes and increased morbidity and mortality. The combination of a long-acting β agonist (LABA) and a muscarinic antagonist (LAMA) is more effective in reducing hyperinflation than LABA-inhaled corticosteroid combination therapy but whether dual bronchodilation improves cardiac function is unknown. METHODS: We did a double-blind, randomised, two-period crossover, placebo-controlled, single-centre study (CLAIM) at the Fraunhofer Institute of Toxicology and Experimental Medicine (Hannover, Germany), a specialty clinic...
February 21, 2018: Lancet Respiratory Medicine
Fangli Men, Lianmin Wei, Bing Liu, Fengting Wu, Jingyu Liu, Ni Guo, Qing Niu
The aim of the present study was to compare the safety of the application of painless gastroscopy and ordinary gastroscopy for chronic hypertension patients combined with early gastric cancer. A total of 123 patients with early gastric cancer were selected at the Dongying People's Hospital from June, 2014 to August, 2016. The patients were randomly divided into the painless (n=63) and ordinary (n=60) gastroscopy groups. Proper pretreatment was performed according to whether anesthesia was performed or not. Arterial pressure, heart rate, and blood oxygen saturation were detected and compared before anesthesia, when gastroscope passed through the esophageal entrance plane, and after recovery from anesthesia...
March 2018: Oncology Letters
Manon van der Vlugt, Esmée J Grobbee, Patrick M Bossuyt, Amanda C R K Bos, Ernst J Kuipers, Iris Lansdorp-Vogelaar, Manon C W Spaander, Evelien Dekker
BACKGROUND & AIMS: European guidelines recommend screening for colorectal cancer (CRC) using the fecal immunochemical test (FIT), with follow-up colonoscopies for individuals with positive test results. However, more than half of participants with positive results from the FIT are not found to have advanced neoplasia in the colonoscopy examination. Fecal occult blood might also come from the upper gastrointestinal (GI) tract, so perhaps we should consider esophagogastroduodenoscopy (EGD), to detect upper GI cancers...
February 7, 2018: Clinical Gastroenterology and Hepatology
Anna A Stec, Kathryn E Dickens, Marielle Salden, Fiona E Hewitt, Damian P Watts, Philip E Houldsworth, Francis L Martin
Cancer incidence appears to be higher amongst firefighters compared to the general population. Given that many cancers have an environmental component, their occupational exposure to products of carbon combustion such as polycyclic aromatic hydrocarbons (PAHs) is of concern. This is the first UK study identifying firefighters exposure to PAH carcinogens. Wipe samples were collected from skin (jaw, neck, hands), personal protective equipment of firefighters, and work environment (offices, fire stations and engines) in two UK Fire and Rescue Service Stations...
February 6, 2018: Scientific Reports
Nadia Benmoussa, Kevin Hansen, Philippe Charlier
INTRODUCTION: Hippocrates, a Greek physician during the fifth century BC., is often considered the father of medicine. The Corpus Hippocraticum comprising of 58 volumes was attributed to him alone for a long time. Nowadays, it is considered that several authors contributed to its creation between 450 and 150 BC., so over a period of 300 years. The objective of our study was to develop a nosological classification of all passages treating head and neck diseases. MATERIAL AND METHODS: We read and analyzed all volumes of the Corpus Hippocraticum in French translation and extracted all passages dealing with oto-rhino-laryngological and maxillo-facial conditions (n = 65)...
January 31, 2018: Acta Oto-laryngologica
Min-Hyun Kim, Junsoo Noh, Sung-Bom Pyun
Objective: To analyze the clinical characteristics between neurogenic and non-neurogenic cause of vocal cord immobility (VCI). Methods: The researchers retrospectively reviewed clinical data of patients who underwent laryngeal electromyography (LEMG). LEMG was performed in the bilateral cricothyroid and thyroarytenoid muscles. A total of 137 patients were enrolled from 2011 to 2016, and they were assigned to either the neurogenic or non-neurogenic VCI group, according to the LEMG results...
December 2017: Annals of Rehabilitation Medicine
Baomin Zheng, Xiaodong Zhu, Mengzhong Liu, Zhenzhou Yang, Ling Yang, Jinyi Lang, Mei Shi, Gang Wu, Xia He, Xiaozhong Chen, Xuping Xi, Dan Zhao, Guangying Zhu
PURPOSE: Oral mucositis is a common unpreventable complication associated with chemoradiation therapy. Shuanghua Baihe tablets have been approved by the Chinese Food and Drug Administration for treating recurrent oral mucosa ulceration. This study assessed whether Shuanghua Baihe tablets could prevent oral mucositis during chemoradiation therapy for locally advanced nasopharyngeal carcinoma. METHODS AND MATERIALS: This multicenter, randomized, double-blind, placebo-controlled trial was conducted at 11 hospitals in China between January 22, 2014, and September 21, 2015...
February 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Sabrina Adorisio, Alessandra Fierabracci, Giulia Gigliarelli, Isabella Muscari, Lorenza Cannarile, Anna Marina Liberati, Maria Carla Marcotullio, Carlo Riccardi, Massimo Curini, Ramon Enrique Robles Zepeda, Domenico V Delfino
Bursera microphylla (BM), one of the common elephant trees, is widely distributed in the Sonoran Desert in Mexico. The Seri ethnic group in the Sonoran Desert uses BM as an anti-inflammatory and painkiller drug for the treatment of sore throat, herpes labialis, abscessed tooth, and wound healing. Dried stems and leaves of BM are used in a tea to relieve painful urination and to stimulate bronchial secretion. Furthermore, BM is used for fighting venereal diseases. To investigate the effects of the hexane fraction of resin methanol extract (BM-H) on cell growth, the acute myeloid cell line (OCI-AML3) was treated with 250, 25, or 2...
March 2018: Integrative Cancer Therapies
Logaraj Ramakreshnan, Nasrin Aghamohammadi, Chng Saun Fong, Awang Bulgiba, Rafdzah Ahmad Zaki, Li Ping Wong, Nik Meriam Sulaiman
Seasonal haze episodes and the associated inimical health impacts have become a regular crisis among the ASEAN countries. Even though many emerging experimental and epidemiological studies have documented the plausible health effects of the predominating toxic pollutants of haze, the consistency among the reported findings by these studies is poorly understood. By addressing such gap, this review aimed to critically highlight the evidence of physical and psychological health impacts of haze from the available literature in ASEAN countries...
January 2018: Environmental Science and Pollution Research International
Samuel Wormald, Anita Lerch, Dmitri Mouradov, Liam O'Connor
Cigarette smoke comprises a large number of carcinogenic substances that can increase DNA mutation load in epithelial cells of the mouth, throat and lungs. While a strong C:A substitution preference is abundant in tobacco-related cancer genomes, detection of complex or less abundant somatic mutation signatures may be confounded by the heterogeneity of carcinogens present in smoke. Trinucleotide signatures are defined for a variety of somatic mutation processes, yet the extent to which this configuration optimally defines and discriminates between mutational processes is not clear...
February 9, 2018: Carcinogenesis
S Raj, D Sharma, P Mate, M R Capoor, K T Bhowmik
BACKGROUND: Patients of head and neck malignancies often develop oral mucositis and invite various pathogens to colonize over it. OBJECTIVES: The objective of this study is to identify the fungi isolated from patients undergoing radiotherapy (RT) for head and neck cancer, to determine the antifungal susceptibility of these isolates and to determine the time and week of fungal colonization. PATIENTS AND METHODS: Three specimens (throat, urine, and blood) were collected from each of the head and neck cancer patients, who were advised RT...
January 2017: Indian Journal of Cancer
Chisato Tomoda, Kiminori Sugino, Tomoaki Tanaka, Yuna Ogimi, Chie Masaki, Junko Akaishi, Kiyomi Y Hames, Akifumi Suzuki, Kenichi Matsuzu, Takashi Uruno, Keiko Ohkuwa, Wataru Kitagawa, Mitsuji Nagahama, Koichi Ito
BACKGROUND: The number of patients who need thyroid surgery has increased worldwide in recent decades. Patients with thyroid disease experience globus pharyngeus as a result of direct compression and edema of the surrounding organs. Thyroid surgery is needed to improve these symptoms or as treatment for thyroid cancer. After thyroid surgery, globus symptoms may become worse and may affect the daily life of the patient for a long time. Psychogenic problems have also been thought to cause the globus sensation...
January 2018: Thyroid: Official Journal of the American Thyroid Association
Andrew G Shuman
Suzie loves to talk. A successful mid-thirties businesswoman, she is a self-described social butterfly-which made her diagnosis of tongue cancer even more devastating. She came to the clinic complaining of a lump in her throat, which in most young healthy people turns out to be benign and easily treated. But not for Suzie, who had a very rare salivary tumor arising in the back of her tongue. Its slow growth was both a blessing and a curse; such tumors do not kill people quickly, but they typically require surgery...
November 2017: Hastings Center Report
Brett W Pelham, Mitsuru Shimizu, Jamie Arndt, Mauricio Carvallo, Sheldon Solomon, Jeff Greenberg
We tested predictions about religiosity and terror management processes in 16 nations. Specifically, we examined weekly variation in Google search volume in each nation for 12 years (all weeks for which data were available). In all 16 nations, higher than usual weekly Google search volume for life-threatening illnesses (cancer, diabetes, and hypertension) predicted increases in search volume for religious content (e.g., God, Jesus, prayer) in the following week. This effect held up after controlling for (a) recent past and annual variation in religious search volume, (b) increases in search volume associated with religious holidays, and (c) variation in searches for a non-life-threatening illness ("sore throat")...
November 1, 2017: Personality & Social Psychology Bulletin
Kristen L Jarman, Sarah D Kowitt, Jennifer Cornacchione Ross, Adam O Goldstein
Background : Text warnings are mandated on cigars sold in the United States (U.S.), however little published research has examined effectiveness of cigar warnings. This is the first study examining the believability of cigar warnings among adults in the U.S. Methods : Adults in the U.S. ( n = 5014) were randomized in a phone survey to receive one of three cigar-specific mandated warning messages ("Cigar smoking can cause cancers of the mouth and throat, even if you do not inhale", "Cigar smoking can cause lung cancer and heart disease", and "Cigars are not a safe alternative to cigarettes") with one of four warning sources (no source, Surgeon General, CDC (Centers for Disease Control and Prevention), FDA (Food and Drug Administration))...
November 10, 2017: International Journal of Environmental Research and Public Health
Ashika V Padgaonkar, Sachin V Suryavanshi, Vaishali Y Londhe, Yogesh A Kulkarni
Bauhinia acuminata commonly known as dwarf white orchid tree is traditionally used to treat acute and chronic pain, skin ailments, cancer, diabetes, throat infections and asthma. As there were no scientific reports on use of Bauhinia acuminata for anti-nociceptive activity, the present study was designed to evaluate possible effects of aqueous and alcoholic extracts in experimentally induced pain in animals. Acute toxicity was carried out as per OECD guideline 423. The anti-nociceptive activity was evaluated in Swiss albino mice by hot plate, acetic acid induced writhing and tail immersion tests at three different dose levels (250, 500 and 1000mg/kg) of aqueous and alcoholic extracts...
October 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Adrian W Midgley, Derek Lowe, Andrew R Levy, Vishal Mepani, Simon N Rogers
The present study aimed to establish exercise preferences, barriers, and perceived benefits among head and neck cancer survivors, as well as their level of interest in participating in an exercise program. Patients treated for primary squamous cell carcinoma of the head and neck between 2010 and 2014 were identified from the hospital database and sent a postal questionnaire pack to establish exercise preferences, barriers, perceived benefits, current physical activity levels, and quality of life. A postal reminder was sent to non-responders 4 weeks later...
October 20, 2017: European Archives of Oto-rhino-laryngology
Karis Kin Fong Cheng, Wan Yim Ip, Vincent Lee, Chak Ho Li, Hui Leung Yuen, Joel B Epstein
OBJECTIVE: Oral mucositis is a frequent clinical condition that has been shown to affect pediatric cancer patients. Oral Mucositis Daily Questionnaire (OMDQ) is one of the few available patient-reported outcome measures to assess the extent and impact of oral mucositis. The objectives of the study were to translate the Mouth and Throat Soreness-Related Questions of the OMDQ into Chinese (OMDQ MTS-Ch) for children and adolescents aged 6-18 years receiving chemotherapy and to evaluate its psychometric properties...
October 2017: Asia-Pacific Journal of Oncology Nursing
Elham Mohebbi, Zahra Noormohamadi, Habib Sadeghi-Rad, Farzin Sadeghi, Yousef Yahyapour, Farzam Vaziri, Ayoub Rahimi, Fatemeh Rahimi Jamnani, Saman Mehrabi, Seyed D Siadat, Mohammad R Noori-Daloii, Abolfazl Fateh
Recent studies show that the human Merkel cell polyomavirus (MCPyV) may be involved in causing cancer. The objective of this study was to assess the impact of MCPyV on the development of head and neck squamous cell carcinoma (HNSCC). In total, 50 paraffin-embedded HNSCC biopsy samples and 50 adjacent non-cancerous samples were evaluated for the presence of MCPyV DNA and RNA. Among patients, the five most frequent histopathologic sites were the tongue (22.0%), lip (16.0%), submandibular (14.0%), cheek (14.0%), and throat (14...
February 2018: Journal of Medical Virology
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