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https://www.readbyqxmd.com/read/29022068/esophagectomy-for-end-stage-achalasia-systematic-review-and-meta-analysis
#1
REVIEW
Alberto Aiolfi, Emanuele Asti, Gianluca Bonitta, Luigi Bonavina
BACKGROUND: Indications for surgery and clinical outcomes of esophagectomy in the management of end-stage achalasia are not clearly defined. The aim of this systematic review and meta-analysis was to provide evidence-based information to help in the decision-making and in the choice of surgical technique. METHODS: An extensive literature search was conducted to identify all reports on esophagectomy for end-stage achalasia patients over the past three decades. MEDLINE, Embase and Cochrane databases were thoroughly consulted matching the terms "achalasia," "end-stage achalasia," "esophagectomy" and "esophageal resection" with "AND" and "OR...
October 11, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28936681/production-of-r-mandelic-acid-using-nitrilase-from-recombinant-e-coli-cells-immobilized-with-tris-hydroxymethyl-phosphine
#2
Xin-Hong Zhang, Zhi-Qiang Liu, Ya-Ping Xue, Yuan-Shan Wang, Bo Yang, Yu-Guo Zheng
Recombinant Escherichia coli cells harboring nitrilase from Alcaligenes faecalis were immobilized using tris(hydroxymethyl)phosphine (THP) as the coupling agent. The optimal pH and temperature of the THP-immobilized cells were determined at pH 8.0 and 55 °C. The half-lives of THP-immobilized cells measured at 35, 40, and 50 °C were 1800, 965, and 163 h, respectively. The concentration of R-mandelic acid (R-MA) reached 358 mM after merely 1-h conversion by the immobilized cells with 500 mM R,S-mandelonitrile (R,S-MN), affording the highest productivity of 1307 g L(-1) day(-1) and the space-time productivity of 143...
September 22, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28915326/adaptive-immunity-and-metabolic-health-harmony-becomes-dissonant-in-obesity-and-aging
#3
Leena P Bharath, Blanche C Ip, Barbara S Nikolajczyk
Adipose tissue (AT) is the primary energy reservoir organ, and thereby plays a critical role in energy homeostasis and regulation of metabolism. AT expands in response to chronic overnutrition or aging and becomes a major source of inflammation that has marked influence on systemic metabolism. The chronic, sterile inflammation that occurs in the AT during the development of obesity or in aging contributes to onset of devastating diseases such as insulin resistance, diabetes, and cardiovascular pathologies. Numerous studies have shown that inflammation in the visceral AT of humans and animals is a critical trigger for the development of metabolic syndrome...
September 12, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/28887268/association-of-advance-directives-completion-with-the-utilization-of-life-sustaining-treatments-during-the-end-of-life-care-in-older-patients
#4
Yung-Feng Yen, Li-Ying Huang, Hsiao-Yun Hu, Wen-Jung Sun, Ming-Chung Ko, Ya-Ling Lee, Sheng-Jean Huang, Dachen Chu
CONTEXT: Evidence is mixed regarding the impact of advance directives (AD) on the utilisation of end-of-life treatments. OBJECTIVES: This study evaluated the effect of AD on the utilization of end-of-life treatments during the last month of life in older patients. METHODS: Taipei City Hospital initiated an advance care planning (ACP) program to promote AD for admitted patients in 2015. This prospective study recruited deceased older patients who completed ACP communication between 2015 and 2016...
September 5, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28813634/hand-assisted-laparoscopic-surgery-versus-conventional-laparoscopic-surgery-for-colorectal-cancer-a-systematic-review-and-meta-analysis
#5
Xubing Zhang, Qingbin Wu, Tao Hu, Chaoyang Gu, Liang Bi, Ziqiang Wang
AIM: This meta-analysis aims to compare hand-assisted laparoscopic surgery (HALS) with conventional laparoscopic surgery (LAS) for colorectal cancer (CRC) in terms of intraoperative, postoperative, and survival outcomes. MATERIALS AND METHODS: A systematic literature search with no limits was performed in PubMed, Embase, and Medline. The last search was performed on March 31, 2017. The outcomes of interests included intraoperative outcomes (operative time, blood loss, length of incision, transfusion, conversion, and lymph nodes harvested), postoperative outcomes (length of hospital stay, time to first flatus, time to first bowel movement, postoperative complications, mortality, reoperation, ileus, anastomotic leakage, postoperative bleeding, wound infection, intra-abdominal abscess, urinary complication, cardiopulmonary complication, and readmission), and 5-year survival outcomes...
August 16, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28758956/fruit-and-vegetable-intake-patterns-and-their-associations-with-sociodemographic-characteristics-anthropometric-status-and-nutrient-intake-profiles-among-malaysian-children-aged-1-6-years
#6
Kar Hau Chong, Shoo Thien Lee, Swee Ai Ng, Ilse Khouw, Bee Koon Poh
This study aimed to assess fruit and vegetable intake patterns and their associations with sociodemographic characteristics, anthropometric status and nutrient intake profiles among Malaysian children aged 1-6 years. Using the Malaysian dataset of South East Asian Nutrition Surveys (SEANUTS Malaysia), a total of 1307 children aged 1-6 years with complete datasets were included in this analysis. Dietary intake was assessed using age-specific, validated food frequency questionnaires. On average, Malaysian children consumed 0...
July 31, 2017: Nutrients
https://www.readbyqxmd.com/read/28732620/results-and-methodology-of-cost-utility-evaluation-of-cataract-surgery-in-developed-countries-quality-adjusted-life-years-and-cataract
#7
REVIEW
Ursula Hahn, Frank Krummenauer
This review surveyed the results and methods of cost-utility analyses of cataract surgery. Thirteen studies were included. Based on decision-theoretic time trade-off, utilities ranged from 0.148 to 0.8 and quality-adjusted life years (QALY) ranged from 1.424 to 2.43. Based on psychometric instruments such as Euroqol 5 dimensions, utilities ranged from 0.017 to 0.056 and QALY ranged from 0.141 to 0.547. Reported costs per QALY were between $1307 and $14 302. Although the review found consistent favorable cost QALY ratios for cataract surgery according to the British National Institute for Care and Health Excellence threshold, the findings raise doubts about the general applicability of existing studies as a tool for allocation decision...
June 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28731929/impact-of-aortic-rather-than-brachial-pulsatile-haemodynamics-on-variations-in-end-organ-measures-across-the-full-adult-blood-pressure-range
#8
Bryan Hodson, Gavin R Norton, Imraan Ballim, Carlos D Libhaber, Pinhas Sareli, Angela J Woodiwiss
AIMS: To determine the extent to which the adverse effects of blood pressure (BP) are mediated by pulsatile haemodynamic changes across the normotensive as compared with the hypertensive adult brachial BP range, and whether aortic rather than brachial pulsatile changes best index these effects. METHODS: In 1307 community participants, the contribution of pulsatile haemodynamics (applanation tonometry and SphygmoCor software) to variations in left ventricular mass index (LVMI) (echocardiography) (n = 920), carotid intima-media thickness (IMT) (n = 712) and estimated glomerular filtration rate (eGFR) (n = 1164) were assessed...
July 20, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28710786/comparison-of-perioperative-and-functional-outcomes-of-robotic-partial-nephrectomy-for-ct1a-vs-ct1b-renal-masses
#9
Christopher R Reynolds, Joan C Delto, David J Paulucci, Corey Weinstein, Ketan Badani, Daniel Eun, Ronney Abaza, James Porter, Akshay Bhandari, Ashok K Hemal
OBJECTIVE: To compare perioperative and functional outcomes of patients with cT1a or cT1b renal masses undergoing robotic partial nephrectomy (RPN) in a large multi-institutional study PATIENTS AND METHODS: The present retrospective Institutional Review Board-approved multi-institutional study utilised a prospectively maintained database to identify patients undergoing RPN by six surgeons for a solitary cT1a (n = 1 307) or cT1b (n = 377) renal mass from 2006 to 2016. Perioperative and renal function outcomes at discharge and at a median follow-up of 12...
July 15, 2017: BJU International
https://www.readbyqxmd.com/read/28624378/glucose-triggered-enhanced-solubilisation-release-and-cytotoxicity-of-poorly-water-soluble-anti-cancer-drugs-fromt1307-micelles
#10
Pooja Patidar, Sadafara A Pillai, Urjita Sheth, Pratap Bahadur, Anita Bahadur
Tetronic(®) 1307 (here after written as T1307) is a hydrophilic ethylene oxide-propylene oxide (EO-PO) star block copolymer with long EO chains (Total MW- 18000 and 70% EO). Although biocompatible, its use as a nanocarrier is restricted owing to its high critical micelle concentration (CMC) and temperature (CMT). We examined if the addition of glucose, a common pharmaceutical ingredient promotes micellization. Scattering and thermal studies show formation of stable unimodal micelles and cloud point (CP) decreased linearly...
June 15, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28604376/aortic-surgery-and-laparoscopy-still-a-future-in-the-endovascular-surgery-era
#11
Pierfrancesco Veroux, Vincenzo Ardita, Alessia Giaquinta, Alberto Davì, Giusi Basile, Massimiliano Veroux
Laparoscopic surgery (LS) is the minimally invasive alternative to open surgery and endovascular approach for treating major aortic diseases. Only few reports in the literature describe the long-term outcomes of the laparoscopic approach for major vascular diseases. Furthermore, the widespread use of endovascular techniques has limited the use of LS to wellselected patients. This review evaluated the results of LS for aortic disease and compared the clinical outcomes of laparoscopic technique with those of open and endovascular surgery...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28594282/availability-of-cyp2d6-genotyping-results-in-general-practitioner-and-community-pharmacy-medical-records
#12
Mirjam Simoons, Hans Mulder, Robert A Schoevers, Henricus G Ruhé, Eric N van Roon
AIM: To investigate the availability of CYP450-2D6 (CYP2D6) genotyping results in general practitioner (GP) and/or community pharmacy records, and the influence thereof on psychotropic CYP2D6 substrate dosing. MATERIALS & METHODS: Primary outcome was the percentage of patients genotyped for CYP2D6 with their genotype/phenotype registered in GP and/or pharmacy records. Secondary outcome was the number of defined daily doses of psychotropic CYP2D6 substrates prescribed after genotyping...
June 8, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28492087/sociodemographic-characteristics-associated-with-the-use-of-effective-and-less-effective-contraceptive-methods-findings-from-the-understanding-fertility-management-in-contemporary-australia-survey
#13
Karen Freilich, Sara Holton, Heather Rowe, Maggie Kirkman, Lynne Jordan, Kathleen McNamee, Christine Bayly, John McBain, Vikki Sinnott, Jane Fisher
OBJECTIVE: Unintended pregnancy and abortion may, in part, result from suboptimal use of effective contraception. This study aimed to identify sociodemographic factors associated with the use of effective and less effective methods among women and men of reproductive age living in Australia. METHODS: In a cross-sectional national survey, 1544 women and men aged 18-51 were identified as being at risk of pregnancy. Chi-square and logistic regression analyses were used to assess the sociodemographic factors related to contraceptive use...
May 11, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28421050/reveromycins-a-and-b-from-streptomyces-sp-3-10-antifungal-activity-against-plant-pathogenic-fungi-in-vitro-and-in-a-strawberry-food-model-system
#14
Ang Lyu, Hao Liu, Hongjie Che, Long Yang, Jing Zhang, Mingde Wu, Weidong Chen, Guoqing Li
This study was conducted to determine the antifungal activity of the metabolites from Streptomyces sp. 3-10, and to purify and identify the metabolites. Meanwhile, the taxonomic status of strain 3-10 was re-evaluated. The cultural filtrates of strain 3-10 in potato dextrose broth were extracted with ethyl acetate. The resulting crude extract at 1 and 5 μg/ml inhibited growth of 22 species in 18 genera of plant pathogenic fungi and Oomycetes, accounting for 92% of the total 24 tested species, suggesting that it has a wide antifungal spectrum...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28396572/vesicular-stomatitis-virus-n-protein-specific-single-domain-antibody-fragments-inhibit-replication
#15
Leo Hanke, Florian I Schmidt, Kevin E Knockenhauer, Benjamin Morin, Sean Pj Whelan, Thomas U Schwartz, Hidde L Ploegh
The transcription and replication machinery of negative-stranded RNA viruses presents a possible target for interference in the viral life cycle. We demonstrate the validity of this concept through the use of cytosolically expressed single-domain antibody fragments (VHHs) that protect cells from a lytic infection with vesicular stomatitis virus (VSV) by targeting the viral nucleoprotein N. We define the binding sites for two such VHHs, 1004 and 1307, by X-ray crystallography to better understand their inhibitory properties...
June 2017: EMBO Reports
https://www.readbyqxmd.com/read/28378129/peer-attachment-specific-patterns-of-internet-use-and-problematic-internet-use-in-male-and-female-adolescents
#16
Iris Reiner, Ana N Tibubos, Jochen Hardt, Kai Müller, Klaus Wölfling, Manfred E Beutel
Problematic internet use may lead to serious psychosocial dysfunction. Recent studies have found comparable prevalence in both male and female adolescents. We pursue the neglected questions how male and female adolescents differ regarding their patterns of internet use and how gender, peer attachment and patterns of use are related to pathological internet use. In 2410 adolescents (1307 girls and 1103 boys) aged 12-18 years from different types of school we assessed peer attachment, frequency and use of eight specific applications and indicators of pathological internet use...
April 4, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28291635/awareness-of-obstructive-sleep-apnea-hypopnea-syndrome-among-the-general-population-of-the-lorraine-region-of-france
#17
F Arous, J-M Boivin, A Chaouat, C Rumeau, R Jankowski, D T Nguyen
OBJECTIVE: Obstructive sleep apnea-hypopnea syndrome (OSAHS) seems to be underdiagnosed. The aim of this study was to assess awareness of OSAHS among the general population of the Lorraine Region of France. METHODS: A descriptive epidemiological study was carried out from July to November 2015 in the Lorraine Region, using an anonymous questionnaire that assessed knowledge of OSAHS-related symptoms and complications. The survey was also circulated on the Internet via social media...
October 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28270657/the-impact-of-poor-asthma-control-among-asthma-patients-treated-with-inhaled-corticosteroids-plus-long-acting-%C3%AE-2-agonists-in-the-united-kingdom-a-cross-sectional-analysis
#18
Ian D Pavord, Nicola Mathieson, Anna Scowcroft, Riccardo Pedersini, Gina Isherwood, David Price
There are several new treatment options for patients whose asthma remains uncontrolled on free-dose and fixed-dose combinations of inhaled corticosteroids plus long-acting β2-agonists (ICS+LABA). In order to evaluate the likely impact of these treatments, we assessed the effect of uncontrolled asthma on healthcare and patient burden within the UK among adult patients treated with ICS+LABA. Data obtained from 2010-2011 UK National Health and Wellness Surveys identified 701 patients treated with ICS+LABA. Patients with not well-controlled asthma (Asthma Control Test™ score <20) were compared with well-controlled asthma (score ≥ 20) patients on multiple measures...
March 9, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28249083/provider-induced-demand-in-the-treatment-of-carotid-artery-stenosis-variation-in-treatment-decisions-between-private-sector-fee-for-service-vs-salary-based-military-physicians
#19
COMPARATIVE STUDY
Louis L Nguyen, Ann D Smith, Rebecca E Scully, Wei Jiang, Peter A Learn, Stuart R Lipsitz, Joel S Weissman, Lorens A Helmchen, Tracey Koehlmoos, Andrew Hoburg, Linda G Kimsey
Importance: Although many factors influence the management of carotid artery stenosis, it is not well understood whether a preference toward procedural management exists when procedural volume and physician compensation are linked in the fee-for-service environment. Objective: To explore evidence for provider-induced demand in the management of carotid artery stenosis. Design, Setting, and Participants: The Department of Defense Military Health System Data Repository was queried for individuals diagnosed with carotid artery stenosis between October 1, 2006, and September 30, 2010...
June 1, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28222364/manufactured-and-roll-your-own-cigarettes-a-changing-pattern-of-smoking-in-barcelona-spain
#20
Xisca Sureda, Marcela Fu, Jose M Martínez-Sánchez, Cristina Martínez, Montse Ballbé, Raúl Pérez-Ortuño, Esteve Saltó, José A Pascual, Esteve Fernández
AIMS: The objectives of the present study were to describe smoking prevalence and compare the smoking attributes of adult smokers according to the type of tobacco product consumed. METHODS: Repeated cross-sectional surveys (2004-2005 and 2011-2012) of a representative sample of the adult (≥16 years) population in Barcelona, Spain, were used to assess self-reported tobacco consumption, smoking attributes, and salivary cotinine concentration. The survey conducted in 2004-2005 included information on 1245 subjects and the survey in 2011-2012 on 1307 individuals...
May 2017: Environmental Research
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