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Sui-Yuan Chang, Pi-Han Lin, Chien-Lin Cheng, Mao-Yuan Chen, Hsin-Yun Sun, Szu-Min Hsieh, Wang-Huei Sheng, Yi-Ching Su, Li-Hsin Su, Shu-Fang Chang, Wen-Chun Liu, Chien-Ching Hung, Shan-Chwen Chang
Antiretroviral therapy containing an integrase strand transfer inhibitor (INSTI) plus two NRTIs has become the recommended treatment for antiretroviral-naive HIV-1-infected patients in the updated guidelines. We aimed to determine the prevalence of INSTI-related mutations in Taiwan. Genotypic resistance assays were performed on plasma from ARV-naïve patients (N = 948), ARV-experienced but INSTI-naive patients (N = 359), and raltegravir-experienced patients (N = 63) from 2006 to 2015. Major INSTI mutations were defined according to the IAS-USA list and other substitutions with a Stanford HIVdb score ≧ 10 to at least one INSTI were defined as minor mutations...
October 25, 2016: Scientific Reports
Prashant Kumar Singh, Priyam Saikia, Mangala Lahakar
BACKGROUND AND AIMS: Considering the paucity of regional data, this study was designed to investigate the prevalence of post-operative pain and determine if there exists any correlation between the intensity of post-operative pain and patient's level of satisfaction with their pain management after inpatient abdominal surgery at an academic tertiary care government centre. METHODS: Pain intensity was measured in 120 patients with numeric rating scale at the fifth post-operative hour, second and third post-operative day...
October 2016: Indian Journal of Anaesthesia
Jesús García-Donas, Benoit Beuselinck, Lucía Inglada-Pérez, Osvaldo Graña, Patrick Schöffski, Agnieszka Wozniak, Oliver Bechter, Maria Apellániz-Ruiz, Luis Javier Leandro-García, Emilio Esteban, Daniel E Castellano, Aranzazu González Del Alba, Miguel Angel Climent, Susana Hernando, José Angel Arranz, Manuel Morente, David G Pisano, Mercedes Robledo, Cristina Rodriguez-Antona
The majority of metastatic renal cell carcinoma (RCC) patients are treated with tyrosine kinase inhibitors (TKI) in first-line treatment; however, a fraction are refractory to these antiangiogenic drugs. MicroRNAs (miRNAs) are regulatory molecules proven to be accurate biomarkers in cancer. Here, we identified miRNAs predictive of progressive disease under TKI treatment through deep sequencing of 74 metastatic clear cell RCC cases uniformly treated with these drugs. Twenty-nine miRNAs were differentially expressed in the tumors of patients who progressed under TKI therapy (P values from 6 × 10(-9) to 3 × 10(-3))...
July 7, 2016: JCI Insight
Wun Fung Hui, Aisha Betoko, Jonathan D Savant, Alison G Abraham, Larry A Greenbaum, Bradley Warady, Marva M Moxey-Mims, Susan L Furth
OBJECTIVE: Our aim was to characterize the nutrient intake of children with chronic kidney disease (CKD) relative to recommended intake levels. METHODS: We conducted a cross-sectional study of dietary intake assessed by Food Frequency Questionnaire (FFQ) in The North American Chronic Kidney Disease in Children (CKiD) prospective cohort study. Nutrient intake was analyzed to estimate the daily consumption levels of various nutrients and compared with national guidelines for intake...
September 29, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Antoni Sicras-Mainar, Javier Rejas-Gutiérrez, María Pérez-Páramo, Ruth Navarro-Artieda
To analyze the effect of loss of exclusivity of data on the cost of treatment of peripheral neuropathic pain (PNP) with pregabalin or gabapentin in routine clinical practice. A retrospective observational study, with electronic medical records for patients enrolled at primary care centers managed by the health care provider Badalona Serveis Assistencials, who initiated treatment of PNP with pregabalin or gabapentin. The analysis used drugs and resources prices for year 2015. The 1163 electronic medical records (pregabalin; N = 764, gabapentin; N = 399) for patients (62...
September 27, 2016: Journal of Evaluation in Clinical Practice
Sadafara A Pillai, Bhavesh Bharatiya, Matilde Casas, Emílio V Lage, Isabel Sandez-Macho, Haridas Pal, Pratap Bahadur
Ethylene oxide-propylene oxide (EO-PO) block copolymer micelles are useful potential nanoreservoirs for the delivery of hydrophobic drugs. Considering that glycine is an excipient and can favorably affect the surface/micellar behavior and thus improve solubilization power/dispersion stability/wetting characteristics we have reported here studies on aqueous solution behavior of two commercially available branched block copolymers (Tetronics(®)) with differing hydrophobicities namely Tetronics(®) 1307 and 1304, hereafter referred as T1307 and T1304, in the presence of glycine...
September 12, 2016: Colloids and Surfaces. B, Biointerfaces
Honsoul Kim, Song-Ee Baek, Jieun Mo On, Yun Ho Roh, Narae Lee, Arthur Cho
PURPOSE: Imaging features of sinusoidal obstruction syndrome (SOS), an increasingly common drawback of chemotherapy, were evaluated via 18F-fluorodeoxyglucose (FDG) positron emission tomography computed tomography (PET/CT). EXPERIMENTAL DESIGN: This retrospective study was approved by our Institutional Review Board, with a waiver of informed consent. FDG PET/CT studies of 35 patients (male, 24; female, 11; median age, 53.2 years) obtained between January, 2005 and December, 2012 were analyzed before and after systemic chemotherapy...
September 1, 2016: Oncotarget
Xiaoli Shi, Jie Kong, Xianhong Meng, Sheng Luan, Kun Luo, Baoxiang Cao, Ning Liu, Xia Lu, Kangyu Deng, Jiawang Cao, Yingxue Zhang, Hengheng Zhang, Xupeng Li
White spot syndrome virus (WSSV) infects all shrimp species and is the greatest detriment to shrimp culture. To better understand the mechanism of molecular responses to WSSV infection in "Huanghai No. 2" Fenneropenaeus chinensis, a microarray technique was used. Microarray gene expression profiling of 59,137 unigenes identified Differentially Expressed Genes (DEGs) both in live and moribund shrimp at early, peak and late phases. In live shrimp, 1307, 1479 and 1539 DEGs were obtained in the early, peak and late phase, respectively...
August 30, 2016: Fish & Shellfish Immunology
Ming Zhao, Hongbo Lin, Yanyan Yuan, Fuyan Wang, Yang Xi, Li Ming Wen, Peng Shen, Shizhong Bu
OBJECTIVE: The aims of the study were to investigate the prevalence of pre-diabetes and explore its associated risk factors in rural areas of Ningbo, China. METHODS: A cross-sectional survey was conducted with 4583 adult residents in rural areas of Ningbo, China between March and May 2013. The survey used a multi-stage, stratified, cluster sampling method. Data collected included demographics and medical history, anthropometric measurements, blood pressure, blood lipid, and plasma glucose...
2016: International Journal of Environmental Research and Public Health
Eric P Moll van Charante, Edo Richard, Lisa S Eurelings, Jan-Willem van Dalen, Suzanne A Ligthart, Emma F van Bussel, Marieke P Hoevenaar-Blom, Marinus Vermeulen, Willem A van Gool
BACKGROUND: Cardiovascular risk factors are associated with an increased risk of dementia. We assessed whether a multidomain intervention targeting these factors can prevent dementia in a population of community-dwelling older people. METHODS: In this open-label, cluster-randomised controlled trial, we recruited individuals aged 70-78 years through participating general practices in the Netherlands. General practices within each health-care centre were randomly assigned (1:1), via a computer-generated randomisation sequence, to either a 6-year nurse-led, multidomain cardiovascular intervention or control (usual care)...
August 20, 2016: Lancet
Lindsay C Kobayashi, Jo Waller, Christian von Wagner, Jane Wardle
BACKGROUND: The NHS Cancer Screening Programmes in England now operate a policy of 'informed choice' about participation in cancer screening. Engagement with written information about screening is important to facilitate informed choice, although the degree to which the screening-eligible public engages with the available information is unknown. We examined the association between reading of the standard informational booklet ('Bowel Cancer Screening: The Facts') and participation in the nationally organised NHS Bowel Cancer Screening Programme in England...
2016: BMC Public Health
John K Chan, Austin B Gardner, Joshua E Chan, Andrew Guan, Mark Alshak, Daniel S Kapp
OBJECTIVE: To determine impact of age and other prognostic factors on the survival of ovarian immature teratoma (IT) patients. METHODS: Data obtained from the SEER database between 1973 and 2012. Kaplan-Meier methods and multivariate Cox regression models were used for statistical analyses. RESULTS: Of 1307 patients (median: 24years; range: 0-93), 78%, 5%, 13%, 4% were stages I, II, III and IV, respectively. 25%, 35%, and 40% had grades 1, 2, and 3...
September 2016: Gynecologic Oncology
Corinna Clio Zygourakis, Victoria Valencia, Chris Moriates, Christy Boscardin, Sereina Catschegn, Andrew Goldberg, Kevin Bozic, Kent Soo Hoo, Rosanna Wustrack, Lawrence H Pitts, Adams Dudley, Ralph Gonzales, Michael T Lawton
INTRODUCTION: Despite the large contribution of surgical expenses to rising health care costs, many surgeons have little knowledge of their operating room (OR) costs. The goal of OR SCORE (OR Surgical Cost Reduction) is to determine whether providing surgeons with cost feedback reduces OR costs. METHODS: We performed a prospective controlled trial from January to December 2015 at University of California San Francisco (UCSF). Each surgeon in the orthopedic, ear, nose, and throat, and neurosurgery departments received standardized scorecards on a monthly basis in 2015...
August 2016: Neurosurgery
Eric T Poon, John O'Reilly, Stephen H Wong
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Yan Li, Yun-Xia Li, Meng-Jie Zhao, An Yuan, Xiao-Hong Gong, Meng-Jun Zhao, Cheng Peng
BACKGROUND AND OBJECTIVES: Aconitum carmichaelii Debx. (Fuzi) is usually compatible with Rheum palmatum L. (Dahuang) in clinic. The study is conducted to investigate the influence of Dahuang on the pharmacokinetics of Fuzi. METHODS: Twelve rats were randomly divided into two groups. Fuzi group was orally administered a single dose of 38.4 mg/kg total alkaloids from Fuzi, and Fuzi-Dahuang group was given 38.4 mg/kg total alkaloids from Fuzi and 76.8 mg/kg Dahuang anthraquinones at the same time...
June 29, 2016: European Journal of Drug Metabolism and Pharmacokinetics
Jorge Emilio Alfonso, David Berlana, Andrew Ukleja, Joseph Boullata
BACKGROUND: Multichamber bags (MCBs) may offer potential clinical, ergonomic, and economic advantages compared with (hospital) pharmacy compounded bags (COBs) and multibottle systems (MBSs). METHODS: A systematic literature review was performed to identify and assess the available evidence regarding advantages of MCBs compared with COBs and MBSs. Medline, Embase, the Cochrane Databases, and EconLit were searched for articles reporting clinical, ergonomic, and economic outcomes for MCBs compared with COBs or MBSs...
June 28, 2016: JPEN. Journal of Parenteral and Enteral Nutrition
Markéta Gloneková, Karolína Brandlová, Magdalena Žáčková, Barbora Dobiášová, Kateřina Pechrová, Jaroslav Šimek
Despite being regularly bred in zoos, giraffes remain a challenge, especially in terms of feeding. Assessment of factors influencing growth and weight changes during ontogeny, as well as analysis of weight fluctuations in adult individuals, may become a critical point in captive diet evaluation. Knowledge about weight is a crucial husbandry tool; however, such data are rarely acquired. Using a unique dataset from regularly weighed Rothschild giraffes (Giraffa camelopardalis rothschildi) from Prague zoo, we determined the growth functions of male and female giraffes and calculated weight gains during giraffe ontogeny...
June 22, 2016: Zoo Biology
Xiaochun Zou, Xinbo Zhao, Jian Wang, Yongjia Yang
For many applications in graphics, design, and human computer interaction, it is essential to understand where humans look in a scene with a particular task. Models of saliency can be used to predict fixation locations, but a large body of previous saliency models focused on free-viewing task. They are based on bottom-up computation that does not consider task-oriented image semantics and often does not match actual eye movements. To address this problem, we collected eye tracking data of 11 subjects when they performed some particular search task in 1307 images and annotation data of 2,511 segmented objects with fine contours and 8 semantic attributes...
2016: Computational Intelligence and Neuroscience
Ertugrul Guclu, Aziz Ogutlu, Oguz Karabay, Tuna Demirdal, Ibrahim Erayman, Salih Hosoglu, Vedat Turhan, Serpil Erol, Nefise Oztoprak, Ayse Batirel, Fatma Aybala Altay, Gulsum Kaya, Mustafa Karahocagil, Hamdi Sozen, Mustafa Yildirim, Funda Kocak, Bahri Teker
This multi-centre study aimed to determine the antibiotic consumption in Turkish hospitals by point prevalence. Antibiotic consumption of 14 centres was determined using the DDD method. Among hospitalized patients, 44.8% were using antibiotics and the total antibiotic consumption was 674.5 DDD/1000 patient-days (DPD). 189.6 (28%) DPD of the antibiotic consumption was restricted while 484.9 (72%) DPD was unrestricted. Carbapenems (24%) and beta lactam/beta lactamase inhibitors (ampicillin-sulbactam or amoxicillin-clavulanate; 22%) were the most commonly used restricted and unrestricted antibiotics...
May 30, 2016: Journal of Chemotherapy
Olivia Nankinga, Cyprian Misinde, Betty Kwagala
BACKGROUND: Sexually transmitted infections (STIs) are a major reproductive and public health concern, especially in the era of HIV/AIDS. This study examined the relationship between sexual empowerment and STI status of women in union (married or cohabiting) in Uganda, controlling for sexual behaviour, partner factors, and women's background characteristics. METHODS: The study, based on data from the 2011 Uganda Demographic and Health Survey (UDHS), analysed 1307 weighted cases of women age 15-49 in union and selected for the domestic violence module...
2016: BMC Public Health
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