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Hideo Masuki, Toshimitsu Okudera, Taisuke Watanebe, Masashi Suzuki, Kazuhiko Nishiyama, Hajime Okudera, Koh Nakata, Kohya Uematsu, Chen-Yao Su, Tomoyuki Kawase
BACKGROUND: The development of platelet-rich fibrin (PRF) drastically simplified the preparation procedure of platelet-concentrated biomaterials, such as platelet-rich plasma (PRP), and facilitated their clinical application. PRF's clinical effectiveness has often been demonstrated in pre-clinical and clinical studies; however, it is still controversial whether growth factors are significantly concentrated in PRF preparations to facilitate wound healing and tissue regeneration. To address this matter, we performed a comparative study of growth factor contents in PRP and its derivatives, such as advanced PRF (A-PRF) and concentrated growth factors (CGF)...
December 2016: Int J Implant Dent
Julia Hehn, Thomas Schwenk, Markus Striegel, Markus Schlee
BACKGROUND: Previous studies have shown that adequate thickness or initial augmentation of soft tissue has a positive effect on the stability of peri-implant bone. This randomized, controlled trial aimed to evaluate the influence of augmenting soft tissue with platelet-rich fibrin (PRF) on crestal bone and soft tissue around implants. METHODS: After randomization, 31 fully threaded titanium implants were inserted in 31 patients (16 men and 15 women) in the lower mandible using a split-flap technique...
December 2016: Int J Implant Dent
Carlos A M Soares, Theo Z Pavan, Andre H Miyague, Marek Kudla, Wellington P Martins
Three-dimensional power Doppler quantification has limited application because of its high dependency on attenuation. The purpose of the study described here was to assess if different degrees of attenuation, depending on pulse repetition frequency (PRF) adjustment, alter 3-D power Doppler quantification in a region of 100% moving blood when using vascularization index, flow index and vascularization flow index (VFI). A cubic-shaped gelatin phantom with a 1.8-mm-internal-diameter silicon tube was used. The tube, placed at 45° to the phantom's surface, was filled with blood-mimicking fluid with as constant maximum velocity of 30 cm/s...
September 24, 2016: Ultrasound in Medicine & Biology
Nikhil D Chandradas, Shivamurthy Ravindra, Vivekananda M Rangaraju, Sheetal Jain, Shivaprasad Dasappa
AIM: To evaluate the efficacy of platelet rich fibrin (PRF) with or without bone graft [demineralized bone matrix (DBM) graft] in the treatment of intrabony defects based on clinical and radiographic parameters. MATERIALS AND METHODS: Thirty six intrabony defects in 36 patients were randomly divided into three different groups and were treated with group A (PRF with DBM) or group B (PRF alone) or group C [open flap debridement (OFD)]. Clinical parameters such as plaque index (PI), gingival index (GI), probing depth (PD), relative attachment level (RAL), and gingival recession (GR) were assessed at baseline and 9 months postoperatively; radiographic parameters such as linear bone growth (LBG) and percentage in bone fill (%BF) were calculated by using the image analysis software...
August 2016: Journal of International Society of Preventive & Community Dentistry
Masako Fujioka-Kobayashi, Richard J Miron, Maria Hernandez, Umadevi Kandalam, Yufeng Zhang, Joseph Choukroun
BACKGROUND: Over the past decade, the use of leukocyte platelet rich fibrin (L-PRF) has gained tremendous momentum in regenerative dentistry as a low-cost fibrin matrix utilized for tissue regeneration. In this study, we characterized how centrifugation speed (G-force) along with centrifugation time influence growth factor release from fibrin clots, as well as the cellular activity of gingival fibroblasts exposed to each PRF matrix. METHODS: Standard L-PRF served as a control (2700rpm-12 minutes)...
September 2, 2016: Journal of Periodontology
M Kapustecki, I Niedzielska, H Borgiel-Marek, B Różanowski
BACKGROUND: Removing a tooth from the jaw results in the occurrence of oroantral communication in beneficial anatomic conditions or in the case of a iatrogenic effect. Popularized treatments of the oroantral communication have numerous faults. Large bone defect eliminates the chance to introduce an implant. Purpose of this work was assessment of the usefulness of autogenous bone graft and PRF in normal bone regeneration in the site of oroantral communication. MATERIAL AND METHODS: Bone regeneration in the site of oroantral communication was assessed in 20 patients...
2016: Medicina Oral, Patología Oral y Cirugía Bucal
L Suzanne Goodell, Susan L Johnson, Amanda C Antono, Thomas G Power, Sheryl O Hughes
Introduction Parents play a key role in the development of eating habits in preschool children, as they are the food "gatekeepers." Repeated exposure to new foods can improve child food preferences and consumption. The objective of this study was to determine parent feeding strategies used to influence child acceptance of previously rejected foods (PRF). Methods We conducted eighteen focus groups (total participants = 111) with low-income African American and Hispanic parents of preschool children (3- to 5-year-olds) in Texas, Colorado, and Washington...
July 21, 2016: Maternal and Child Health Journal
Özer Erdem Gür, Nuray Ensari, Mehmet Türker Öztürk, Osman Fatih Boztepe, Taylan Gün, Ömer Tarık Selçuk, Levent Renda
OBJECTIVES: (1) To evaluate the effects of a platelet-rich fibrin (PRF) membrane in the repair of traumatic tympanic membrane (TM) perforations; and (2) to compare the use of a PRF membrane with the paper patch technique with regard to recovery rates, healing time, and correction of the mean air-bone gap. METHODS: A randomized, prospective analysis was performed for 60 patients who were treated for traumatic TM perforations using one of the two methods. Closure rate, speed of healing, and hearing gain were compared between the PRF (Group 1) and paper patch (Group 2) groups...
October 2016: Acta Oto-laryngologica
Pooja Gupta Dudeja, Krishan Kumar Dudeja, Arvind Garg, Dhirendra Srivastava, Shibani Grover
Teeth with calcified canals, dilacerated roots, and associated large periradicular lesions involving both cortical plates pose a challenge to dentists. In addition to the nonsurgical endodontic treatment, such teeth may require surgical intervention with concomitant use of bone grafting materials and barrier techniques. These techniques, when combined with the use of a host modulating agent such as platelet-rich fibrin (PRF), may improve the chances of success. A 26-year-old woman was referred for dental treatment with a recurrence of an intraoral sinus tract 2 months after periradicular surgery in the upper anterior region...
June 2016: Journal of Endodontics
Qi Lin Wang, Pan Pan Yang, Li Hong Ge, He Liu
OBJECTIVE: To evaluate the use of platelet-rich fibrin (PRF) in the regenerative therapy of immature canine permanent teeth. METHODS: Eight immature premolars of beagle dogs were pulp extracted and cleaned with irrigation, then divided into two groups of empty root canals and those filled with a PRF clot. All of the eight premolars were sealed with mineral trioxide aggregate and glass ionomer cement. Two premolars were left naturally grown as a positive control...
March 2016: Chinese Journal of Dental Research
Eizaburo Kobayashi, Laura Flückiger, Masako Fujioka-Kobayashi, Kosaku Sawada, Anton Sculean, Benoit Schaller, Richard J Miron
OBJECTIVES: The use of platelet concentrates has gained increasing awareness in recent years for regenerative procedures in modern dentistry. The aim of the present study was to compare growth factor release over time from platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and a modernized protocol for PRF, advanced-PRF (A-PRF). MATERIALS AND METHODS: Eighteen blood samples were collected from six donors (3 samples each for PRP, PRF, and A-PRF). Following preparation, samples were incubated in a plate shaker and assessed for growth factor release at 15 min, 60 min, 8 h, 1 day, 3 days, and 10 days...
January 25, 2016: Clinical Oral Investigations
Koen Van Boxem, Nelleke de Meij, Jacob Patijn, Jan Wilmink, Maarten van Kleef, Jan Van Zundert, Alfons Kessels
BACKGROUND: In a previous prospective study on pulsed radiofrequency (PRF) treatment adjacent to the lumbar dorsal root ganglion (DRG) for patients with chronic lumbosacral radicular pain, we reported success in 55.4% of the patients at 6 months. Identification of predictors for success after PRF may improve outcome. We assessed the predictors of PRF in patients with chronic intractable lumbosacral radicular pain. METHODS: Patients with monosegmental chronic lumbosacral radicular pain of L5 or S1 first received a selective nerve root block at the corresponding level...
January 20, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Qiong Yao, Xi-Hong Hu, Quan-Li Shen, Zhong-Wei Qiao, Mi-Er Pa, Bin Qian, Wei-Li Yan, Guo-Ying Huang
We aimed to compare the diagnostic value of indexed right ventricular end-diastolic volume (RVEDVi) and the ratio of right ventricle volume to left ventricle volume (RV/LV ratio) in prediction of the severity of pulmonary regurgitation (PR) expressed as the PR fraction (PRF) after surgery of tetralogy of Fallot (TOF). Forty-one patients with repaired TOF were included in the study. RVEDVi, LVEDVi, RV/LV ratio, PRF and ejection fraction were measured with magnetic resonance imaging. A PRF of more than 20% was considered significant...
2016: Cardiology
Florian Nadon, Benoit Chaput, Jean Périssé, Ambre de Bérail, Frédéric Lauwers, Raphaël Lopez
The authors describe a new material termed mineralized plasmatic matrix (MPM), a combination of platelets, fibrin concentrate, and autogenous bone to repair alveolar cleft defects. Autogenous cancellous bone is widely used to this end because such bone affords the functionalities (osteogenesis, osteoinduction, and osteoconduction) required for successful outcomes. To optimize these features, autologous blood products high in platelet concentrations have recently been developed. On the basis of our experience with PRP (platelet-rich plasma) and PRF (platelet-rich fibrin), we developed MPM, which contains platelets and fibrin concentrate in a liquid state; these materials can become bound to bone particles...
October 2015: Journal of Craniofacial Surgery
Beatrice Femminella, Maria Chiara Iaconi, Marcella Di Tullio, Luigi Romano, Bruna Sinjari, Camillo D'Arcangelo, Paolo De Ninis, Michele Paolantonio
BACKGROUND: Platelet-rich fibrin (PRF) promotes tissue regeneration by releasing various growth factors. The palatal donor site of the epithelialized connective tissue (CT) graft significantly influences the patient's morbidity. The aim of this study is to compare the effects of PRF and gelatin sponge on the healing of palatal donor sites and the patient's morbidity. METHODS: Forty patients with at least one site of Miller Class I or II gingival recession were treated by a coronally advanced flap with CT graft resulting from the de-epithelialization of a free gingival graft...
February 2016: Journal of Periodontology
Gaurav Vidhale, Deepali Jain, Sourabh Jain, Alkesh Vijayrao Godhane, Ganesh R Pawar
Radicular cyst is one of the most commonly occurring cyst in the oral cavity it is usually preceded by trauma or an infectious condition which is followed by enlargement. In recent times there are several treatment procedures that are being applied in order to improve the postoperative condition and to accelerate the process of healing and regeneration in the affected site. A 22-year-old patient reported to our OPD with the chief complaint of swelling on the left side of the face since 2-3 months, on investigating it was diagnosed as Radicular cyst which was initially treated by endodontic treatment of the involved tooth followed by enucleation of the cyst further an apicoectomy was done...
June 2015: Journal of Clinical and Diagnostic Research: JCDR
Mark Small, Victoria Higgins, Adam Lees, Nicola Johns, Anthony Mastrangelo, Tara Nazareth, Stuart J Turner
A retrospective analysis of a cross-sectional, multicenter survey was conducted in United States (US) medical practices to evaluate the concordance between patients with COPD and their physicians on disease-specific characteristics. Associations between patient and disease-related characteristics with monotherapy, dual therapy, or triple therapy prescribed as COPD maintenance regimens were also examined. Eligible physicians completed patient record forms (PRFs) for up to 6 consecutive patients with COPD. Patients for whom a PRF was completed were invited to complete a patient self-completion (PSC) survey consisting of questions similar to those on the PRF, as well as several validated measures to assess the impact of COPD on patients' lives...
2015: COPD
Zhenhua Cong, Zhaojun Liu, Zengguang Qin, Xingyu Zhang, Shiwu Wang, Han Rao, Qiang Fu
This paper describes a high pulse repetition frequency Nd:YAG twisted-mode laser that uses an RTP crystal as the electro-optic Q-switch. Stable single-longitudinal-mode laser beams at 1, 5, and 10 kHz were obtained with a linewidth less than 0.1 GHz. Under an incident pump power of 7.5 W and a PRF of 10 kHz, the maximum output power of the single-longitudinal-mode laser was 1.19 W. The corresponding conversion efficiency, single pulse energy and pulse peak power were 15.8%, 119 μJ, and 2.5 kW, respectively...
June 1, 2015: Applied Optics
Xiao-Lin Sun, Yan-Min Zhou, Jing-Hui Zhao, Ling Zheng, Ting-Ting Yang
PURPOSE: To investigate the effect of platelet-rich fibrin on biologic characteristics of osteoblasts. METHODS: Osteoblasts were cultured with or without a PRF membrane. The cell proliferation was detected by MTT. The alkaline phosphatase (ALP) stain and the positive expression of collagen type I, osteoprotegerin and RANKL were measured. The data was statistically analyzed with SPSS17.0 software package. RESULTS: PRF promoted cell proliferation and increased expression of ALP, collagen typeI and OPG significantly, but there was no significant impact on expression of RANKL...
February 2015: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
Jeong-Hwa Yang, Gwansuk Kang, Min Joo Choi
PURPOSE: The aim of this experimental study was to evaluate whether the acoustic radiation force (ARF) is a potential source of twinkling artifacts in color Doppler images. METHODS: Color Doppler images were obtained using a clinical ultrasonic scanner (Voluson e, GE Healthcare) for a high contrast (+15 dB) circular scattering phantom at pulse repetition frequencies (PRFs) ranging from 0.1 to 13 kHz. Ultrasound transmissions resulting in ARF were measured using a hydrophone at the various PRFs considered...
April 2015: Ultrasonography
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