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https://www.readbyqxmd.com/read/29436564/the-effects-of-celery-leaf-apium-graveolens-l-treatment-on-blood-glucose-and-insulin-levels-in-elderly-pre-diabetics
#1
Yusni Yusni, Hendra Zufry, Firdalena Meutia, Krishna W Sucipto
To analyze the effect of celery leaf extract on blood glucose and plasma insulin levels in elderly pre-diabetics. Methods: This study was conducted between March and November 2014 at the Faculty of Medicine, Syiah Kuala University, Banda Aceh, Indonesia. A quasi-experimental pretest-posttest with a control group was conducted with elderly pre-diabetic volunteers. The subjects included 16 elderly pre-diabetics older than 60 (6 males and 10 females). The subjects were randomly divided into 2 groups: a control group (placebo-treated) and a treatment group (celery-treated)...
February 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29427177/trends-in-diabetes-treatment-and-monitoring-among-medicare-beneficiaries
#2
Bruce E Landon, Alan M Zaslavsky, Jeffrey Souza, John Z Ayanian
BACKGROUND: Diabetes is a costly and common condition, but little is known about recent trends in diabetes management among Medicare beneficiaries. OBJECTIVE: To evaluate the use of diabetes medications and testing supplies among Medicare beneficiaries. DESIGN/SETTING: Retrospective cohort analysis of Medicare claims from 2007 to 2014. PARTICIPANTS: Traditional Medicare beneficiaries with a diagnosis of diabetes in the current or any prior year...
February 9, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29356912/current-status-and-issues-of-the-artificial-pancreas-abridged-english-translation-of-a-special-issue-in-japanese
#3
REVIEW
Tsutomu Namikawa, Masaya Munekage, Tomoaki Yatabe, Hiroyuki Kitagawa, Kazuhiro Hanazaki
Surgical stress induces hyperglycemia and gives rise to glucose toxicity, which causes infectious diseases, resulting in unfavorable surgical outcomes. Intensive insulin treatment can control short- and long-term complications in patients with not only diabetes mellitus, but also surgical diabetes; however, it is associated with an increased risk of hypoglycemia. The wearable artificial pancreas was originally developed to control glucose levels in patients with type 1 diabetes, progressing to a device with enhanced stability and safety for these patients...
January 22, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29251783/effect-of-metformin-on-hypothalamic-pituitary-thyroid-axis-activity-in-elderly-antipsychotic-treated-women-with-type-2-diabetes-and-subclinical-hypothyroidism-a-preliminary-study
#4
Robert Krysiak, Witold Szkróbka, Bogusław Okopień
Metformin was found to reduce elevated serum thyrotropin levels, and this effect was partially determined by endogenous dopaminergic tone. The aim of this study was to compare the effect of metformin treatment on hypothalamic-pituitary-thyroid axis activity in elderly women with subclinical hypothyroidism treated with antipsychotic agents and not receiving this drug. The study population consisted of 34 elderly women with subclinical hypothyroidism, 16 of whom received antipsychotic drugs. Because of coexistent type 2 diabetes, these women were treated with metformin (2...
December 18, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29228945/trends-in-incidence-of-proximal-humerus-fractures-surgical-procedures-and-outcomes-among-elderly-hospitalized-patients-with-and-without-type-2-diabetes-in-spain-2001-2013
#5
Maria Angeles Martinez-Huedo, Rodrigo Jiménez-García, Eduardo Mora-Zamorano, Valentín Hernández-Barrera, Manuel Villanueva-Martinez, Ana Lopez-de-Andres
BACKGROUND: Several studies have reported that diabetic persons have an increased risk for fractures than non-diabetes patients. The association between proximal humerus fractures and type 2 diabetes (T2DM) is unclear and some studies point to insulin treatment, hypoglycaemic episodes consequently to inadequate control of diabetes or, more recently, to an alteration of trabecular bone. We examined trends in the incidence of proximal humerus fractures, surgical procedures and outcomes among hospitalized patients aged ≥65 years, with and without T2DM in Spain, 2001-2013...
December 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29215660/-prioritization-of-non-recommended-clinical-activities-in-primary-care
#6
L García Mochon, A Olry de Labry Lima, C Bermudez-Tamayo
OBJECTIVE: To prioritize non-recommended clinical activities in Primary Care (PC), from "Do not do" recommendations listed by the Sociedad Española de Medicina de Familia y Comunitaria (Semfyc), according to expert consensus (physicians, nurses and pharmacists). METHODS: The consensus for the prioritization of non-recommended practices in PC was performed through an online procedure. We used as a base the list of "do not-do" recommendations of the SEMFYC. We asked the experts to prioritize practices that should be de-adopted in PC, based on four prioritization criteria: frequency of occurrence, cost of the activity, ease of disposal and damage caused, which were scored from one to five, according to their recommendation...
December 7, 2017: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/29209633/protein-intake-especially-vegetable-protein-intake-is-associated-with-higher-skeletal-muscle-mass-in-elderly-patients-with-type-2-diabetes
#7
Akane Miki, Yoshitaka Hashimoto, Shinobu Matsumoto, Emi Ushigome, Takuya Fukuda, Takafumi Sennmaru, Muhei Tanaka, Masahiro Yamazaki, Michiaki Fukui
Background/Aims: Protein intake is important for maintaining muscle mass in general population. However, it remains to be elucidated the association between dietary protein intake and skeletal muscle mass in elderly patients with type 2 diabetes. Methods: In this cross-sectional study of 168 elderly patients with type 2 diabetes, we investigated the relationship between skeletal muscle index (SMI) and protein intake. Bioimpedance analysis was used for measurement for skeletal muscle mass (kg) and SMI (%), which was defined as skeletal muscle mass (kg)/total body weight (kg) × 100...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29202033/synthetic-smart-gel-provides-glucose-responsive-insulin-delivery-in-diabetic-mice
#8
Akira Matsumoto, Miyako Tanaka, Hiroko Matsumoto, Kozue Ochi, Yuki Moro-Oka, Hirohito Kuwata, Hironori Yamada, Ibuki Shirakawa, Taiki Miyazawa, Hitoshi Ishii, Kazunori Kataoka, Yoshihiro Ogawa, Yuji Miyahara, Takayoshi Suganami
Although previous studies have attempted to create "electronics-free" insulin delivery systems using glucose oxidase and sugar-binding lectins as a glucose-sensing mechanism, no successful clinical translation has hitherto been made. These protein-based materials are intolerant of long-term use and storage because of their denaturing and/or cytotoxic properties. We provide a solution by designing a protein-free and totally synthetic material-based approach. Capitalizing on the sugar-responsive properties of boronic acid, we have established a synthetic polymer gel-based insulin delivery device confined within a single catheter, which exhibits an artificial pancreas-like function in vivo...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29193561/effectiveness-and-tolerability-of-therapy-with-exenatide-once-weekly-versus-basal-insulin-among-injectable-na%C3%A3-ve-elderly-or-renal-impaired-patients-with-type-2-diabetes-in-the-united-states
#9
Anita M Loughlin, Qing Qiao, Anthony Philip Nunes, Peter Öhman, Stephen Ezzy, Laura Yochum, C Robin Clifford, Robert Gately, David D Dore, John Seeger
AIM: To evaluate the effectiveness and tolerability of exenatide once-weekly (EQW) compared to basal insulin (BI) among injectable-naïve T2DM patients who are elderly or have renal impairment (RI). METHODS AND MATERIALS: Initiators of EQW and BI with T2DM were identified from 2012-2015 within a United States electronic health record database and matched by propensity score. Matched EQW and BI initiators aged 65+ years or who have RI were compared. Weight, HbA1c, eGFR, blood pressure, and lipids were obtained at baseline and quarterly (Q1-Q4) or semi-annually for one year following drug initiation...
November 30, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29139589/severe-fasting-hypoglycemia-in-a-child-after-total-pancreatectomy-with-islet-autotransplantation
#10
Jacob M Redel, Jaimie D Nathan, Maisam Abu-El-Haija, Tom K Lin, Joseph J Palermo, Deborah A Elder
TPIAT is an increasingly utilized treatment option for select children with CP. Post-TPIAT fasting hypoglycemia, unrelated to exogenous insulin, is a complication recently reported in adults. This phenomenon has not been described in children. We review a case of severe fasting hypoglycemia in an adolescent female occurring 10 months post-TPIAT. A 12-year-old girl underwent TPIAT for CP. Ten months postoperatively she developed recurrent hypoglycemia on a total daily insulin dose of 0.03 units/kg. Consequently, insulin therapy was discontinued...
November 15, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29119382/role-of-brown-adipose-tissue-in-metabolic-syndrome-aging-and-cancer-cachexia
#11
REVIEW
Meng Dong, Jun Lin, Wonchung Lim, Wanzhu Jin, Hyuek Jong Lee
Brown adipose tissue (BAT) plays a fundamental role in maintaining body temperature by producing heat. BAT that had been know to exist only in mammals and the human neonate has received great attention for the treatment of obesity and diabetes due to its important function in energy metabolism, ever since it is recently reported that human adults have functional BAT. In addition, beige adipocytes, brown adipocytes in white adipose tissue (WAT), have also been shown to take part in whole body metabolism. Multiple lines of evidence demonstrated that transplantation or activation of BAT or/and beige adipocytes reversed obesity and improved insulin sensitivity...
November 8, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29106815/high-dose-glucocorticoids-treatment-does-not-induce-severe-hyperglycemia-in-young-patients-with-autoimmune-diseases-by-cgms
#12
Ying Zhou, Yan Zhao, Tao Yuan, Nan Jiang, Yingyue Dong, Yunjiao Yang, Li Wang, Jiuliang Zhao, Le Min, Weigang Zhao
INTRODUCTION: High-dose glucocorticoids (HDG) are used in the treatment of autoimmune diseases. Glucocorticoids-induced hyperglycemia (GIH) is often described in elderly patients. In young patients with autoimmune diseases, however, the risk for GIH has not been well characterized. METHODS: Twenty-four inpatients (median age 32 years (interquatile range 25-42)) with exacerbations of autoimmune diseases, receiving 1-2mg/kg/day prednisone or equivalent methylprednisone, were recruited...
November 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28977924/antihyperglycemic-treatment-in-patients-with-type-2-diabetes-in-italy-the-impact-of-age-and-kidney-function
#13
Sandro Gentile, Pamela Piscitelli, Francesca Viazzi, Giuseppina Russo, Antonio Ceriello, Carlo Giorda, Piero Guida, Paola Fioretto, Roberto Pontremoli, Felice Strollo, Salvatore De Cosmo
We describe AHA utilization pattern according to age and renal function in type 2 diabetes mellitus (T2DM), in real-life conditions. The analysis was performed using the data set of electronic medical records collected between 1 January and 31 December, 2011 in 207 Italian diabetes centers. The study population consisted of 157,595 individuals with T2DM. The AHA treatment regimens was evaluated. Kidney function was assessed by eGFR, estimated using the CKD-EPI formula. Other determinations: HbA1c, blood pressure (BP), low- density lipoprotein (LDL-c), total and high density lipoprotein cholesterol (TC and HDL-c), triglycerides (TG) and serum uric acid (SUA)...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28966225/a-case-report-of-fulminant-type-1-diabetes-mellitus-associated-with-drug-induced-hypersensitivity-syndrome-in-an-elderly-patient-with-coxsackie-b4-virus-infection-and-human-leukocyte-antigen-a24-haplotype
#14
Ayumu Takeno, Ippei Kanazawa, Miwa Morita, Kai Takedani, Hitomi Miyake, Masahiro Yamamoto, Kyoko Nogami, Sakae Kaneko, Toshitsugu Sugimoto
Drug-induced hypersensitivity syndrome (DIHS) is a severe systemic adverse drug reaction. Previous studies showed that DIHS is associated with the onset of fulminant type 1 diabetes mellitus (FT1D). Although genetic background and abnormalities in immune response or viral infection are considered to be associated with pathogenesis of FT1D, it remains unclear whether virus infection and specific human leukocyte antigen (HLA) typing are involved in DIHS-associated FT1D. Here, we report a case of a 78-year-old female patient with FT1D after DIHS treatment...
September 29, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28943478/sexual-dimorphism-of-metabolic-and-vascular-dysfunction-in-aged-mice-and-those-lacking-the-sphingosine-1-phosphate-receptor-3
#15
Amanda T Cao, Martina Mackova, Daniel Kerage, David N Brindley, Denise G Hemmings
Elderly people often suffer adverse health because of inflammation associated with poor metabolism and cardiovascular dysfunction, but these conditions present differently in men and women. We performed experiments in aged male and female mice to understand this sexual dimorphism. We focused on sphingosine 1-phosphate (S1P) signaling, which has both protective and detrimental effects on vascular and metabolic function. We examined vascular function of mesenteric (resistance) arteries from aged male and female wild-type (WT) mice compared to littermate S1P receptor 3 (S1PR3) knockouts (KO)...
December 1, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28939527/assessment-of-fructose-overload-in-the-metabolic-profile-and-oxidative-nitrosative-stress-in-the-kidney-of-senescent-female-rats
#16
Deborah Chianelli Costalonga Seraphim, Giovana Rita Punaro, Thamires de Oliveira Fernandes, Milton Ginoza, Guiomar Silva Lopes, Elisa Mieko Suemitsu Higa
The aging process is a complex phenomenon that leads the body to several changes, affecting its integrity and resulting in chronic pathologies, which compromises health and quality of life of elderly people. Animals supplemented with fructose have been used as an experimental model for induction of insulin resistance. The objective of this study was to evaluate the metabolic effects and the levels of oxidative/nitrosative stress in the kidney of senescent rats with a high fructose intake. The animals were allocated into 4 groups: young control (Y), aged control (A), young fructose (YF) and aged fructose (AF)...
December 1, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28935388/%C3%AE-cell-function-over-time-in-adolescents-with-new-type-2-diabetes-and-obese-adolescents-without-diabetes
#17
Deborah A Elder, Lindsey N Hornung, Jane C Khoury, David A D'Alessio
PURPOSE: The progression of β-cell function in newly diagnosed adolescents with type 2 diabetes mellitus (T2DM) is not well documented. We hypothesized that at the time of diagnosis with T2DM, adolescents would have impaired β-cell function as demonstrated by the disposition index (calculated as: insulin secretion adjusted for insulin sensitivity), and this would be followed by a rapid decline of function despite standard medical management. METHODS: Thirty-nine adolescents with recently diagnosed T2DM and 32 obese adolescent controls with normal glucose tolerance had acute insulin response to glucose, homeostatic model assessment of insulin resistance, and disposition index measured serially over 2 years...
September 18, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28918198/are-we-missing-hypoglycaemia-elderly-patients-with-insulin-treated-diabetes-present-to-primary-care-frequently-with-non-specific-symptoms-associated-with-hypoglycaemia
#18
Suzy V Hope, Phil J Taylor, Beverley M Shields, Andrew T Hattersley, Willie Hamilton
INTRODUCTION: We assessed if patients with known hypoglycaemia present on other occasions with non-specific symptoms associated with (but not diagnosed as) hypoglycaemia, potentially representing missed hypoglycaemia. METHODS: 335 primary care records (5/2/12-4/2/13) from patients aged >65 (79 on insulin, 85 on sulphonylureas, 121 on metformin only, 50 without diabetes) were assessed for hypoglycaemia episodes and consultations with non-specific symptoms, "hypo clues"...
September 11, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28899347/case-report-of-hyperglycemic-nonketotic-chorea-with-rapid-radiological-resolution
#19
H M M T B Herath, S P Pahalagamage, Sunethra Senanayake
BACKGROUND: Hemichorea is a rare manifestation of nonketotic hyperglycemia that usually affects elderly Asian women with poor glycemic control. Non-contrast computerized Tomography and T1- weighted Magnetic Resonance Imaging shows characteristic hyperintense basal ganglia lesions. CASE PRESENTATION: A Fifty-seven year old Sri Lankan female presented with a two-day history of right upper limb chorea. She had been diagnosed with diabetes mellitus one year ago, but was not on any treatment and did not have any micro vascular or macro vascular complications...
September 12, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28870545/arterial-stiffness-and-cognitive-impairment
#20
REVIEW
Xiaoxuan Li, Peiyuan Lyu, Yanyan Ren, Jin An, Yanhong Dong
BACKGROUND: Arterial stiffness is one of the earliest indicators of changes in vascular wall structure and function and may be assessed using various indicators, such as pulse-wave velocity (PWV), the cardio-ankle vascular index (CAVI), the ankle-brachial index (ABI), pulse pressure (PP), the augmentation index (AI), flow-mediated dilation (FMD), carotid intima media thickness (IMT) and arterial stiffness index-β. Arterial stiffness is generally considered an independent predictor of cardiovascular and cerebrovascular diseases...
September 15, 2017: Journal of the Neurological Sciences
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