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https://www.readbyqxmd.com/read/27924134/a-physical-map-of-important-qtls-functional-markers-and-genes-available-for-sesame-breeding-programs
#1
Komivi Dossa
Sesame is one of the oldest oilseed crops grown mainly in Africa and Asia. Although genetic and genomic studies on sesame have started late, the past 5 years have witnessed extensive progresses in these areas on this crop. Important genomic sequence resources such as functional markers, genes and QTLs linked to agronomically important traits, have been generated through linkage mapping and association analysis to assist sesame improvement programs. However, most of these data are scattered in different maps making them hard to be exploited efficiently in breeding programs...
October 2016: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/27914852/a-call-to-strengthen-the-global-strategy-against-schistosomiasis-and-soil-transmitted-helminthiasis-the-time-is-now
#2
REVIEW
Nathan C Lo, David G Addiss, Peter J Hotez, Charles H King, J Russell Stothard, Darin S Evans, Daniel G Colley, William Lin, Jean T Coulibaly, Amaya L Bustinduy, Giovanna Raso, Eran Bendavid, Isaac I Bogoch, Alan Fenwick, Lorenzo Savioli, David Molyneux, Jürg Utzinger, Jason R Andrews
In 2001, the World Health Assembly (WHA) passed the landmark WHA 54.19 resolution for global scale-up of mass administration of anthelmintic drugs for morbidity control of schistosomiasis and soil-transmitted helminthiasis, which affect more than 1·5 billion of the world's poorest people. Since then, more than a decade of research and experience has yielded crucial knowledge on the control and elimination of these helminthiases. However, the global strategy has remained largely unchanged since the original 2001 WHA resolution and associated WHO guidelines on preventive chemotherapy...
November 30, 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27896724/genomic-database-searching
#3
James R A Hutchins
The availability of reference genome sequences for virtually all species under active research has revolutionized biology. Analyses of genomic variations in many organisms have provided insights into phenotypic traits, evolution and disease, and are transforming medicine. All genomic data from publicly funded projects are freely available in Internet-based databases, for download or searching via genome browsers such as Ensembl, Vega, NCBI's Map Viewer, and the UCSC Genome Browser. These online tools generate interactive graphical outputs of relevant chromosomal regions, showing genes, transcripts, and other genomic landmarks, and epigenetic features mapped by projects such as ENCODE...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27886811/morphoarchitectural-variation-in-south-african-fossil-cercopithecoid-endocasts
#4
Amélie Beaudet, Jean Dumoncel, Frikkie de Beer, Benjamin Duployer, Stanley Durrleman, Emmanuel Gilissen, Jakobus Hoffman, Christophe Tenailleau, John Francis Thackeray, José Braga
Despite the abundance of well-preserved crania and natural endocasts in the South African Plio-Pleistocene cercopithecoid record, which provide direct information relevant to the evolution of their endocranial characteristics, few studies have attempted to characterize patterns of external brain morphology in this highly successful primate Superfamily. The availability of non-destructive penetrating radiation imaging systems, together with recently developed computer-based analytical tools, allow for high resolution virtual imaging and modeling of the endocranial casts and thus disclose new perspectives in comparative paleoneurology...
December 2016: Journal of Human Evolution
https://www.readbyqxmd.com/read/27882504/media-portrayal-of-a-landmark-neuroscience-experiment-on-free-will
#5
Eric Racine, Valentin Nguyen, Victoria Saigle, Veljko Dubljevic
The concept of free will has been heavily debated in philosophy and the social sciences. Its alleged importance lies in its association with phenomena fundamental to our understandings of self, such as autonomy, freedom, self-control, agency, and moral responsibility. Consequently, when neuroscience research is interpreted as challenging or even invalidating this concept, a number of heated social and ethical debates surface. We undertook a content analysis of media coverage of Libet's et al.'s (Brain 106(Pt 3):623-642, 1983) landmark study, which is frequently interpreted as posing a serious challenge to the existence of free will...
November 23, 2016: Science and Engineering Ethics
https://www.readbyqxmd.com/read/27875190/combined-visualization-of-vessel-deformation-and-hemodynamics-in-cerebral-aneurysms
#6
Monique Meuschke, Samuel Voss, Oliver Beuing, Bernhard Preim, Kai Lawonn
We present the first visualization tool that combines patient-specific hemodynamics with information about the vessel wall deformation and wall thickness in cerebral aneurysms. Such aneurysms bear the risk of rupture, whereas their treatment also carries considerable risks for the patient. For the patient-specific rupture risk evaluation and treatment analysis, both morphological and hemodynamic data have to be investigated. Medical researchers emphasize the importance of analyzing correlations between wall properties such as the wall deformation and thickness, and hemodynamic attributes like the Wall Shear Stress and near-wall flow...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27874150/the-radiological-research-for-pelvis-asymmetry-of-unilateral-developmental-dysplasia-of-the-hip-in-adult
#7
Ya-Min Li, Jue-Hong Li, Bin Li, Jia-Xing Wang, Yun-Su Chen
To investigate whether adult patients with unilateral developmental dysplasia of the hip (UDDH) have pelvic asymmetry and what correlation existing between them. Methods: A total of 100 adult patients with UDDH were enrolled in the retrospective observational study in Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China, between January 2012 and February 2014. The anteroposterior pelvic radiographs were reviewed and the pelvic heights and ischium heights were measured and compared between the affected and non-affected sides to find out the relationship between the pelvic morphology and hip dysplasia...
December 2016: Saudi Medical Journal
https://www.readbyqxmd.com/read/27872577/sex-determination-using-discriminant-function-analysis-in-indigenous-kurubas-children-and-adolescents-of-coorg-karnataka-india-a-lateral-cephalometric-study
#8
Darshan Devang Divakar, Jacob John, Abdulaziz Abdullah Al Kheraif, Seema Mavinapalla, Ravikumar Ramakrishnaiah, Sajith Vellappally, Mohamed Ibrahim Hashem, M H N Dalati, B H Durgesh, Rima A Safadi, Sukumaran Anil
Aim: To test the validity of sex discrimination using lateral cephalometric radiograph and discriminant function analysis in Indigenous (Kuruba) children and adolescents of Coorg, Karnataka, India. Methods and materials: Six hundred and sixteen lateral cephalograms of 380 male and 236 females of age ranging from 6.5 to 18 years of Indigenous population of Coorg, Karnataka, India called Kurubas having a normal occlusion were included in the study. Lateral cephalograms were obtained in a standard position with teeth in centric occlusion and lips relaxed...
November 2016: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/27855737/genetic-basis-of-chronotype-in-humans-insights-from-three-landmark-gwas
#9
David A Kalmbach, Logan D Schneider, Joseph Cheung, Sarah J Bertrand, Thiruchelvam Kariharan, Allan I Pack, Philip R Gehrman
Chronotype, or diurnal preference, refers to behavioral manifestations of the endogenous circadian system that governs preferred timing of sleep and wake. As variations in circadian timing and system perturbations are linked to disease development, the fundamental biology of chronotype has received attention for its role in the regulation and dysregulation of sleep and related medical and psychiatric illnesses. Twin and family studies have shown that chronotype is a heritable trait, thus directing attention toward its genetic basis...
October 28, 2016: Sleep
https://www.readbyqxmd.com/read/27842565/regional-anesthesia-for-painful-injuries-after-disasters-rapid-study-protocol-for-a-randomized-controlled-trial
#10
Adam C Levine, Carrie Teicher, Adam R Aluisio, Tess Wiskel, Pola Valles, Miguel Trelles, Justin Glavis-Bloom, Rebecca F Grais
BACKGROUND: Lower extremity trauma during earthquakes accounts for the largest burden of disaster-related injuries. Insufficient pain management is common in resource-limited disaster settings, and regional anesthesia (RA) may reduce pain in injured patients beyond current standards of care. To date, no controlled trials have been conducted to evaluate the use of RA for pain management in a disaster setting. METHODS/DESIGN: The Regional Anesthesia for Painful Injuries after Disasters (RAPID) study aims to evaluate whether regional anesthesia (RA), either with or without ultrasound (US) guidance, can reduce pain from earthquake-related lower limb injuries in a disaster setting...
November 14, 2016: Trials
https://www.readbyqxmd.com/read/27836503/in-vitro-hip-testing-in-the-international-society-of-biomechanics-coordinate-system
#11
Richard J van Arkel, Jonathan R T Jeffers
Many innovative experiments are designed to answer research questions about hip biomechanics, however many fail to define a coordinate system. This makes comparisons between studies unreliable and is an unnecessary hurdle in extrapolating experimental results to clinical reality. The aim of this study was to present a specimen mounting protocol which aligns and registers hip specimens in the International Society of Biomechanics (ISB) coordinate system, which is defined by bony landmarks that are identified by palpation of the patient׳s body...
October 29, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27816086/quantity-and-quality-of-homework-compliance-a-meta-analysis-of-relations-with-outcome-in-cognitive-behavior-therapy
#12
Nikolaos Kazantzis, Craig Whittington, Leah Zelencich, Michael Kyrios, Peter J Norton, Stefan G Hofmann
Homework assignments have been shown to produce both causal and correlational effects in prior meta-analytic reviews of cognitive behavior therapy (CBT), but this research area has been characterized by a focus on the amount of compliance (i.e., quantity), and little is known about the role of skill acquisition (i.e., quality). A landmark study by Neimeyer and Feixas (1990) showed stronger homework-outcome relations when quality was assessed, but previous reviews have not considered whether the same pattern is evident across studies...
September 2016: Behavior Therapy
https://www.readbyqxmd.com/read/27812962/implications-of-the-empa-reg-trial-for-clinical-care-and-research
#13
REVIEW
Angeliki M Stamatouli, Silvio E Inzucchi
EMPA-REG OUTCOME was a multicenter, randomized placebo-controlled trial that examined the effect of empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor in addition to standard of care in patients with type 2 diabetes and established cardiovascular (CV) disease. The primary goal was to assess CV safety, as mandated by the US Food and Drug Administration since 2008 for all new glucose-lowering agents. Secondary goals were to examine the effects of empagliflozin on microvascular outcomes and, in particular, kidney disease...
December 2016: Current Diabetes Reports
https://www.readbyqxmd.com/read/27812480/interfacial-materials-for-organic-solar-cells-recent-advances-and-perspectives
#14
Zhigang Yin, Jiajun Wei, Qingdong Zheng
Organic solar cells (OSCs) have shown great promise as low-cost photovoltaic devices for solar energy conversion over the past decade. Interfacial engineering provides a powerful strategy to enhance efficiency and stability of OSCs. With the rapid advances of interface layer materials and active layer materials, power conversion efficiencies (PCEs) of both single-junction and tandem OSCs have exceeded a landmark value of 10%. This review summarizes the latest advances in interfacial layers for single-junction and tandem OSCs...
August 2016: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/27796401/geometric-morphometrics-of-different-malocclusions-in-lateral-skull-radiographs
#15
Josef Freudenthaler, Aleš Čelar, Christopher Ritt, Philipp Mitteröcker
BACKGROUND: To evaluate the role of craniofacial shape in malocclusion by application of geometric morphometrics to a set of two-dimensional landmarks and semilandmarks obtained from lateral skull radiographs. METHODS: Cephalometric radiograph tracings of 88 untreated Caucasians (age range 7-39 years) were assigned to four groups according to their occlusion: neutrocclusion, distocclusion, mesiocclusion, and anterior open bite. The geometric morphometric shape analysis incorporated 66 landmarks and semilandmarks, which underwent generalized Procrustes analysis, between-groups principal component analysis, thin-plate spline deformation grid visualization, permutation tests, and receiver operating characteristic curves...
October 31, 2016: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/27766137/epidemiology-of-colorectal-cancer
#16
Andrew R Marley, Hongmei Nan
Colorectal cancer is currently the third deadliest cancer in the United States and will claim an estimated 49,190 U.S. lives in 2016. The purpose of this review is to summarize our current understanding of this disease, based on nationally published statistics and information presented in peer-reviewed journal articles. Specifically, this review will cover the following topics: descriptive epidemiology (including time and disease trends both in the United States and abroad), risk factors (environmental, genetic, and gene-environment interactions), screening, prevention and control, and treatment...
2016: International Journal of Molecular Epidemiology and Genetics
https://www.readbyqxmd.com/read/27765878/diagnosing-pediatric-malnutrition-paradigm-shifts-of-etiology-related-definitions-and-appraisal-of-the-indicators
#17
Sandra Bouma
The publication of the landmark paper "Defining Pediatric Malnutrition: A Paradigm Shift Toward Etiology-Related Definitions" launched a new era in diagnosing pediatric malnutrition. This work introduced the paradigm shift of etiology-related definitions-nonillness and illness related-and the use of anthropometric z scores to help identify and describe children with malnutrition (undernutrition) in the developed world. Putting the new definition into practice resulted in some interesting observations: (1) Etiology-related definitions result in etiology-related interventions...
October 20, 2016: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/27751787/scientific-profile-of-brain-computer-interfaces-bibliometric-analysis-in-a-10-year-period
#18
Kejia Hu, Chao Chen, Qingyao Meng, Ziv Williams, Wendong Xu
BACKGROUND: With the tremendous advances in the field of brain-computer interfaces (BCI), the literature in this field has grown exponentially; examination of highly cited articles is a tool that can help identify outstanding scientific studies and landmark papers. This study examined the characteristics of 100 highly cited BCI papers over the past 10 years. METHODS: The Web of Science was searched for highly cited papers related to BCI research published from 2006 to 2015...
December 2, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27738751/a-kinematic-examination-of-hand-perception
#19
Lara A Coelho, Giovanna Zaninelli, Claudia L R Gonzalez
Previous research has found that the perception of our hands is inaccurate. This distorted representation has several constant characteristics including an overestimation of hand width and an underestimation of finger length. In this study, we further investigate this phenomenon by exploring the boundaries of hand representation. Participants placed one hand underneath a table top so it was occluded from view. Using their free hand, participants were instructed to point to the location where they believed the tips and bases of each of their fingers were...
October 13, 2016: Psychological Research
https://www.readbyqxmd.com/read/27736742/a-rational-choice-for-translational-research
#20
Tim Aitman, Paraminder Dhillon, Aron M Geurts
Future prospects continue to be strong for research using the rat as a model organism. New technology has enabled the proliferation of many new transgenic and knockout rat strains, the genomes of more than 40 rat strains have been sequenced, publications using the rat as a model continue to be produced at a steady rate, and discoveries of disease-associated genes and mechanisms from rat experiments abound, frequently with conservation of function between rats and humans. However, advances in genome technology have led to increasing insights into human disease directly from human genetic studies, pulling more and more researchers into the human genetics arena and placing funding for model organisms and their databases under threat...
October 1, 2016: Disease Models & Mechanisms
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