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https://www.readbyqxmd.com/read/28220268/anterolateral-ligament-expert-group-consensus-paper-on-the-management-of-internal-rotation-and-instability-of-the-anterior-cruciate-ligament-deficient-knee
#1
REVIEW
Bertrand Sonnery-Cottet, Matthew Daggett, Jean-Marie Fayard, Andrea Ferretti, Camilo Partezani Helito, Martin Lind, Edoardo Monaco, Vitor Barion Castro de Pádua, Mathieu Thaunat, Adrian Wilson, Stefano Zaffagnini, Jacco Zijl, Steven Claes
Purpose of this paper is to provide an overview of the latest research on the anterolateral ligament (ALL) and present the consensus of the ALL Expert Group on the anatomy, radiographic landmarks, biomechanics, clinical and radiographic diagnosis, lesion classification, surgical technique and clinical outcomes. A consensus on controversial subjects surrounding the ALL and anterolateral knee instability has been established based on the opinion of experts, the latest publications on the subject and an exchange of experiences during the ALL Experts Meeting (November 2015, Lyon, France)...
February 20, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/28217505/noncommunicable-disease-in-rural-india-are-we-seriously-underestimating-the-risk-the-nallampatti-noncommunicable-disease-study
#2
Krishnan Swaminathan, Ganesh Veerasekar, Sujatha Kuppusamy, Mohanraj Sundaresan, Ganesan Velmurugan, Nalla G Palaniswami
AIM: To assess the prevalence of noncommunicable diseases in a true rural farming population in South India and compare the data with the landmark contemporary Indian Council of Medical Research-India Diabetes (ICMR-INDIAB) study. METHODS: Local Ethics Committee approval and informed consent was obtained from all participants. Inclusion criteria were participants, aged ≥20 and ≤85 years, from Nallampatti, a classical farming village from Tamil Nadu state, India...
January 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28217294/molecular-hydrogen-a-therapeutic-antioxidant-and-beyond
#3
REVIEW
Lei Huang
Molecular hydrogen (H2) medicine research has flourished since a landmark publication in Nature Medicine that revealed the antioxidant and cytoprotective effects of hydrogen gas in a focal stroke model. Emerging evidence has consistently demonstrated that molecular hydrogen is a promising therapeutic option for a variety of diseases and the underlying comprehensive mechanisms is beyond pure hydroxyl radicals scavenging. The non-toxicity at high concentrations and rapid cellular diffusion features of molecular hydrogen ensure the feasibility and readiness of its clinical translation to human patients...
October 2016: Medical Gas Research
https://www.readbyqxmd.com/read/28208764/spatial-impairment-and-memory-in-genetic-disorders-insights-from-mouse-models
#4
Sang Ah Lee, Valter Tucci, Giorgio Vallortigara
Research across the cognitive and brain sciences has begun to elucidate some of the processes that guide navigation and spatial memory. Boundary geometry and featural landmarks are two distinct classes of environmental cues that have dissociable neural correlates in spatial representation and follow different patterns of learning. Consequently, spatial navigation depends both on the type of cue available and on the type of learning provided. We investigated this interaction between spatial representation and memory by administering two different tasks (working memory, reference memory) using two different environmental cues (rectangular geometry, striped landmark) in mouse models of human genetic disorders: Prader-Willi syndrome (PWScr(m+/p-) mice, n = 12) and Beta-catenin mutation (Thr653Lys-substituted mice, n = 12)...
February 9, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28196766/projecting-the-self-outside-the-body-body-representations-underlying-proprioceptive-imagery
#5
Nataşa Ganea, Matthew R Longo
Recent research has shown that proprioception relies on distorted representations of body size and shape. By asking participants to localise multiple landmarks on their occluded hand, perceptual maps of hand size and shape can be constructed and compared to actual hand structure. These maps are different from the actual size and shape of the occluded hand, revealing underestimation of finger length and overestimation of hand width. Here we tested whether the same distorted body model underlies proprioceptive imagery (i...
February 11, 2017: Cognition
https://www.readbyqxmd.com/read/28192864/a-reassessment-of-cervical-surface-anatomy-via-ct-scan-in-an-adult-chinese-population
#6
Xin-Hua Shen, Hua-Dan Xue, Yu Chen, Man Wang, S Ali Mirjalili, Zhu-Hua Zhang, Chao Ma
Surface landmarks in the neck are important for orientations of cervical glands, arteries, veins, nerves and vertebrae. Recent research suggests some orientations are not correct. What are the cervical landmark orientations in the Chinese population? In this study, two essential cervical anatomy planes, the thyroid cartilage and C7 planes, were assessed in living adult Chinese subjects using computed tomography (CT), and the hyoid, carotid bifurcation, cricoid cartilage, thyroid arteries and vertebral artery were simultaneously positioned...
February 13, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28183212/3d-biometrics-for-hindfoot-alignment-using-weightbearing-ct
#7
François Lintz, Matthew Welck, Alessio Bernasconi, James Thornton BSc, Nicholas P Cullen, Dishan Singh, Andy Goldberg
BACKGROUND: Hindfoot alignment on 2D radiographs can present anatomical and operator-related bias. In this study, software designed for weightbearing computed tomography (WBCT) was used to calculate a new 3D biometric tool: the Foot and Ankle Offset (FAO). We described the distribution of FAO in a series of data sets from clinically normal, varus, and valgus cases, hypothesizing that FAO values would be significantly different in the 3 groups. METHODS: In this retrospective cohort study, 135 data sets (57 normal, 38 varus, 40 valgus) from WBCT (PedCAT; CurveBeam LLC, Warrington, PA) were obtained from a specialized foot and ankle unit...
February 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28174317/dual-antiplatelet-therapy-and-clinical-outcomes-after-coronary-drug-eluting-stent-implantation-in-patients-on-hemodialysis
#8
Yung-Tai Chen, Hung-Ta Chen, Chien-Yi Hsu, Pei-Wen Chao, Shu-Chen Kuo, Shuo-Ming Ou, Chia-Jen Shih
BACKGROUND AND OBJECTIVES: We aimed to investigate the benefits and risks of dual antiplatelet therapy (DAPT) after coronary drug-eluting stent (DES) implantation in patients undergoing hemodialysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A nested case-control analysis of patients on hemodialysis after receipt of DES and DAPT treatment was conducted using data from Taiwan's National Health Insurance Research Database for the period 2007-2011. Cases of myocardial infarction or death within 1 year after DES implantation were matched one-to-one with control patients...
February 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28168691/sexual-dimorphism-of-the-first-rib-a-comparative-approach-using-metric-and-geometric-morphometric-analyses
#9
Jeffrey James Lynch, Peter Cross, Vivienne Heaton
This research investigated the sexual dimorphism of the first human rib using geometric morphometric and metric approaches on a sample of 285 specimens containing European Americans and African Americans from the Hamann-Todd collection. Metric measurements were investigated for sexual dimorphism and ancestral differences using univariate statistics. Four type II landmarks and 40 sliding semi-landmarks were placed outlining the dorsal and ventral curvatures of the ribs. Landmark data were processed using Generalized Procrustes Analyses with Procrustes distance sliding, and the subsequent coordinates were investigated for sexual dimorphism and ancestral differences using Procrustes ANOVAs...
February 7, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28165148/a-correlative-study-of-the-allantois-in-pig-and-rabbit-highlighting-the-diversity-of-extraembryonic-tissues-in-four-mammalian-species-including-mouse-and-man
#10
Waad Hassan, Christoph Viebahn
Despite its conserved role in placenta and umbilical cord formation, the mammalian allantois shows remarkable diversity in size and form as well as in the timing of its appearance and attachment to the chorion. In the mouse, the common allantoic diverticulum is lacking; instead, the allantoic core domain is defined as a progenitor center for allantoic development. In this study, the allantoises of the pig and the rabbit as two nonrodent mammals of increasing significance in biomedical research are compared (1) morphologically using high resolution light and electron microscopy and (2) molecularly using brachyury mRNA expression as a mesodermal marker...
February 6, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28161593/a-generalized-active-shape-model-for-segmentation-of-liver-in-low-contrast-ct-volumes
#11
Mina Esfandiarkhani, Amir Hossein Foruzan
PURPOSE: To improve segmentation of normal/abnormal livers in contrast-enhanced/non-contrast CT image using the Active Shape Model (ASM) algorithm; we introduce a generalized profile model. We also intend to accurately detect boundary of liver where it touches nearby organs with similar intensities. METHOD: Initial boundary of a liver in a CT slice is found using an intensity-based technique and it is then represented by a set of points. The profile of a boundary point is represented by a generalized edge model and the parameters of the model are obtained using a non-linear fitting scheme...
January 24, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28153583/evolution-of-skin-grafting-for-treatment-of-burns-reverdin-pinch-grafting-to-tanner-mesh-grafting-and-beyond
#12
REVIEW
Mansher Singh, Kristo Nuutila, K C Collins, Anne Huang
BACKGROUND: Skin grafting is the current standard care in the treatment of full thickness burns. It was first described around 1500 BC but the vast majority of advancements have been achieved over the past 200 years. METHODS: An extensive literature review was conducted on Pubmed, Medline and Google Scholar researching the evolution of skin grafting techniques. The authors concentrated on the major landmarks of skin grafting and also provide an overview of ongoing research efforts in this field...
January 30, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28150107/acne-and-rosacea
#13
REVIEW
Mauro Picardo, Lawrence F Eichenfield, Jerry Tan
Acne, one of the most common skin diseases, affects approximately 85% of the adolescent population, and occurs most prominently at skin sites with a high density of sebaceous glands such as the face, back, and chest. Although often considered a disease of teenagers, acne is occurring at an increasingly early age. Rosacea is a chronic facial inflammatory dermatosis characterized by flushing (or transient facial erythema), persistent central facial erythema, inflammatory papules/pustules, and telangiectasia. Both acne and rosacea have a multifactorial pathology that is incompletely understood...
January 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28145692/from-carbon-based-nanotubes-to-nanocages-for-advanced-energy-conversion-and-storage
#14
Qiang Wu, Lijun Yang, Xizhang Wang, Zheng Hu
Carbon-based nanomaterials have been the focus of research interests in the past 30 years due to their abundant microstructures and morphologies, excellent properties, and wide potential applications, as landmarked by 0D fullerene, 1D nanotubes, and 2D graphene. With the availability of high specific surface area (SSA), well-balanced pore distribution, high conductivity, and tunable wettability, carbon-based nanomaterials are highly expected as advanced materials for energy conversion and storage to meet the increasing demands for clean and renewable energies...
February 1, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28134823/correction-of-monogenic-and-common-retinal-disorders-with-gene-therapy
#15
REVIEW
Jesse D Sengillo, Sally Justus, Thiago Cabral, Stephen H Tsang
The past decade has seen major advances in gene-based therapies, many of which show promise for translation to human disease. At the forefront of research in this field is ocular disease, as the eye lends itself to gene-based interventions due to its accessibility, relatively immune-privileged status, and ability to be non-invasively monitored. A landmark study in 2001 demonstrating successful gene therapy in a large-animal model for Leber congenital amaurosis set the stage for translation of these strategies from the bench to the bedside...
January 27, 2017: Genes
https://www.readbyqxmd.com/read/28131856/embryology-meets-molecular-biology-deciphering-the-apical-ectodermal-ridge
#16
REVIEW
Jamie M Verheyden, Xin Sun
More than sixty years ago, while studying feather tracks on the shoulder of the chick embryo, Dr. John Saunders used Nile Blue dye to stain the tissue. There, he noticed a darkly stained line of cells that neatly rims the tip of the growing limb bud. Rather than ignoring this observation, he followed it up by removing this tissue and found that it led to a striking truncation of the limb skeletons. This landmark experiment marks the serendipitous discovery of the apical ectodermal ridge (AER), the quintessential embryonic structure that drives the outgrowth of the limb...
January 25, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28121962/a-ct-based-simulation-study-to-compare-the-risk-of-facet-joint-violation-by-the-cervical-pedicle-screw-between-degenerative-and-nondegenerative-cervical-spines
#17
Dong-Ho Lee, Hyounmin Noh, Chang Ju Hwang, Choon Sung Lee, Kuniyoshi Abumi, Jae Hwan Cho
STUDY DESIGN: A retrospective case-control study. OBJECTIVE: This study aimed (A) to compare entry points and trajectories of the cervical pedicle screw (CPS) between degenerative and nondegenerative spines, and (B) to evaluate the risk of facet joint violation by the CPS according to the degree of facet degeneration. SUMMARY OF BACKGROUND DATA: Entry point, trajectories, and risk of misplacement of the CPS have been widely researched; however, its application to degenerative cervical spine has to be elucidated...
February 2017: Spine
https://www.readbyqxmd.com/read/28113308/webly-supervised-fine-grained-visual-categorization-via-deep-domain-adaptation
#18
Zhe Xu, Shaoli Huang, Ya Zhang, Dacheng Tao
Learning visual representations from web data has recently attracted attention for object recognition. Previous studies have mainly focused on overcoming label noise and data bias and have shown promising results by learning directly from web data. However, we argue that it might be better to transfer knowledge from existing human labeling resources to improve performance at nearly no additional cost. In this paper, we propose a new semi-supervised method for learning via web data. Our method has the unique design of exploiting strong supervision, i...
December 8, 2016: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28102030/impact-of-sodium-glucose-cotransporter-2-inhibitors-on-nonglycemic-outcomes-in-patients-with-type-2-diabetes
#19
Jennifer M Trujillo, Wesley A Nuffer
The efficacy of the sodium-glucose cotransporter 2 (SGLT2) inhibitors canagliflozin, dapagliflozin, and empagliflozin in reducing hyperglycemia in patients with type 2 diabetes is well documented. In addition, positive effects have been observed with these agents on nonglycemic variables, such as reductions in body weight and blood pressure, which may confer additional health benefits. SGLT2 inhibitors are also associated with evidence of renal-protecting benefits. Furthermore, during the landmark Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes (EMPA-REG OUTCOME) trial, a substantial reduction in major adverse cardiovascular outcomes was demonstrated with empagliflozin therapy...
January 19, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28101648/the-limits-of-boundaries-unpacking-localization-and-cognitive-mapping-relative-to-a-boundary
#20
Ruojing Zhou, Weimin Mou
Previous research (Zhou, Mou, Journal of Experimental Psychology: Learning, Memory and Cognition 42(8):1316-1323, 2016) showed that learning individual locations relative to a single landmark, compared to learning relative to a boundary, led to more accurate inferences of inter-object spatial relations (cognitive mapping of multiple locations). Following our past findings, the current study investigated whether the larger number of reference points provided by a homogeneous circular boundary, as well as less accessible knowledge of direct spatial relations among the multiple reference points, would lead to less effective cognitive mapping relative to the boundary...
January 19, 2017: Psychological Research
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