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https://www.readbyqxmd.com/read/28712912/multixplore-visual-exploration-platform-for-multimodal-neuroimaging-data
#1
Saeed M Bakhshmand, Ali R Khan, Sandrine de Ribaupierre, Roy Eagleson
BACKGROUND: Construction of brain functional and structural networks by neuroimaging methods facilitates inter-modal studies. These type of studies often demand exploration tools to carry out functional-structural discoveries and answer questions regarding the anatomical basis of brain networks. NEW METHOD: This paper describes the design and development of a software module for interactive visualization and exploration of dual-modal brain networks. Our objective was to equip the user with a research tool to investigate brain connectivity matrices while visualizing relevant anatomical landmarks within a 3D volumetric view...
July 13, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28707243/research-trends-and-hotspots-related-to-ammonia-oxidation-based-on-bibliometric-analysis
#2
Maosheng Zheng, Hui-Zhen Fu, Yuh-Shan Ho
Ammonia oxidation is the rate-limiting and central step in global biogeochemistry cycle of nitrogen. A bibliometric analysis based on 4314 articles extracted from Science Citation Index Expanded database was carried out to provide insights into publication performances and research trends of ammonia oxidation in the period 1991-2014. These articles were originated from a wide range of 602 journals and 95 Web of Science Categories, among which Applied and Environmental Microbiology and Environmental Sciences took the leading position, respectively...
July 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28704414/examining-the-use-of-amazon-s-mechanical-turk-for-edge-extraction-of-the-occlusal-surface-of-fossilized-bovid-teeth
#3
Gregory J Matthews, George K Thiruvathukal, Maxwell P Luetkemeier, Juliet K Brophy
In order to reconstruct environments associated with Plio-Pleistocene hominins in southern Africa, researchers frequently rely upon the animals associated with the hominins, in particular, animals in the Family Bovidae. Bovids in southern Africa are typically identified by their teeth. However, identifying the taxon of a bovid tooth is challenging due to various biasing factors. Furthermore, inaccurate identification of fossil bovids can have significant consequences on the reconstructed paleoenvironment. Recent research on the classification of bovid fossil teeth has relied on using elliptical Fourier analysis to summarize the shape of the outline of the occlusal surface of the tooth and the resulting harmonic amplitudes...
2017: PloS One
https://www.readbyqxmd.com/read/28699568/evaluation-of-the-informatician-perspective-determining-types-of-research-papers-preferred-by-clinicians
#4
Boshu Ru, Xiaoyan Wang, Lixia Yao
BACKGROUND: To deliver evidence-based medicine, clinicians often reference resources that are useful to their respective medical practices. Owing to their busy schedules, however, clinicians typically find it challenging to locate these relevant resources out of the rapidly growing number of journals and articles currently being published. The literature-recommender system may provide a possible solution to this issue if the individual needs of clinicians can be identified and applied...
July 5, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28699246/a-potential-pitfall-in-studies-of-biological-shape-does-size-matter
#5
David Outomuro, Frank Johansson
The number of published studies using geometric morphometrics (GM) for analysing biological shape has increased steadily since the beginning of the 1990's, covering multiple research areas such as ecology, evolution, development, taxonomy and palaeontology. Unfortunately, we have observed that many published studies using GM do not evaluate the potential allometric effects of size on shape, which normally require consideration or assessment. This might lead to misinterpretations and flawed conclusions in certain cases, especially when size effects explain a large part of the shape variation...
July 12, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28686631/a-new-approach-for-the-analysis-of-facial-growth-and-age-estimation-iris-ratio
#6
Carlos Eduardo Palhares Machado, Marta Regina Pinheiro Flores, Laíse Nascimento Correia Lima, Rachel Lima Ribeiro Tinoco, Ademir Franco, Ana Cristina Barreto Bezerra, Martin Paul Evison, Marco Aurélio Guimarães
The study of facial growth is explored in many fields of science, including anatomy, genetics, and forensics. In the field of forensics, it acts as a valuable tool for combating child pornography. The present research proposes a new method, based on relative measurements and fixed references of the human face-specifically considering measurements of the diameter of the iris (iris ratio)-for the analysis of facial growth in association with age in children and sub-adults. The experimental sample consisted of digital photographs of 1000 Brazilian subjects, aged between 6 and 22 years, distributed equally by sex and divided into five specific age groups (6, 10, 14, 18, and 22 year olds ± one month)...
2017: PloS One
https://www.readbyqxmd.com/read/28685390/cancer-care-coordination-a-systematic-review-and-meta-analysis-of-over-30%C3%A2-years-of-empirical-studies
#7
Sherri Sheinfeld Gorin, David Haggstrom, Paul K J Han, Kathleen M Fairfield, Paul Krebs, Steven B Clauser
BACKGROUND: According to a landmark study by the Institute of Medicine, patients with cancer often receive poorly coordinated care in multiple settings from many providers. Lack of coordination is associated with poor symptom control, medical errors, and higher costs. PURPOSE: The aims of this systematic review and meta-analysis were to (1) synthesize the findings of studies addressing cancer care coordination, (2) describe study outcomes across the cancer continuum, and (3) obtain a quantitative estimate of the effect of interventions in cancer care coordination on service system processes and patient health outcomes...
July 6, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28684296/a-systematic-investigation-of-navigation-impairment-in-chronic-stroke-patients-evidence-for-three-distinct-types
#8
Michiel H G Claessen, Johanna M A Visser-Meily, Tobias Meilinger, Albert Postma, Nicolien K de Rooij, Ineke J M van der Ham
OBJECTIVE: In a recent systematic review, Claessen and van der Ham (2017) have analyzed the types of navigation impairment in the single-case study literature. Three dissociable types related to landmarks, locations, and paths were identified. This recent model as well as previous models of navigation impairment have never been verified in a systematic manner. The aim of the current study was thus to investigate the prevalence of landmark-based, location-based, and path-based navigation impairment in a large sample of stroke patients...
July 3, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28680647/accuracy-of-anthropometric-measurements-by-general-practitioners-in-overweight-and-obese-patients
#9
Paul Sebo, François R Herrmann, Dagmar M Haller
BACKGROUND: We recently showed that abdominal obesity measurements (waist and hip circumference, waist-to-hip ratio) were inaccurate when performed by general practitioners (GPs). We hypothesise that measurement error could be even higher in overweight and obese patients due to difficulty in locating anatomical landmarks. We aimed to estimate GPs' measurement error of general (weight, height and body mass index (BMI)) and abdominal obesity measurements across BMI subgroups. METHODS: This cross-sectional study involved 26 GPs in Geneva, Switzerland...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28677167/anterior-femoral-bow-and-possible-effect-on-the-stifle-joint-a-comparison-between-humans-and-dogs
#10
M K Ocal, S S Sabanci, M Cobanoglu, M Enercan
The aim of the study was to compare the anterior bow of the femur between dogs and humans in terms of the possible impact on the stifle joint. The femoral radiographs obtained retrospectively were used to determine the angles and positions of the anterior bow in both dogs (n = 135) and humans (n = 57). Descriptive statistics and Pearson's correlation analysis were used for the statistical analyses of the variables. The mean anterior bow angle (ABA) was 18.3 ± 2.02° and 4.88 ± 1.24° in dogs and humans, respectively...
July 4, 2017: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/28659977/facial-mobility-after-maxilla-mandibular-advancement-in-patients-with-severe-obstructive-sleep-apnea-syndrome-a-three-dimensional-study
#11
Laura Verzé, Francesca Antonella Bianchi, Niccolò Barla, Serena Maria Curti, Giovanni Gerbino, Guglielmo Amedeo Ramieri
Introduction. The functional results of surgery in terms of facial mobility are key elements in the treatment of patients. Little is actually known about changes in facial mobility following surgical treatment with maxillomandibular advancement (MMA). Objectives. The three-dimensional (3D) methods study of basic facial movements in typical OSAS patients treated with MMA was the topic of the present research. Materials and Methods. Ten patients affected by severe obstructive sleep apnea syndrome (OSAS) were engaged for the study...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28656622/a-population-level-atlas-of-mus-musculus-craniofacial-skeleton-and-automated-image-based-shape-analysis
#12
A Murat Maga, Nicholas J Tustison, Brian B Avants
Laboratory mice are staples for evo/devo and genetics studies. Inbred strains provide a uniform genetic background to manipulate and understand gene-environment interactions, while their crosses have been instrumental in studies of genetic architecture, integration and modularity, and mapping of complex biological traits. Recently, there have been multiple large-scale studies of laboratory mice to further our understanding of the developmental basis, evolution, and genetic control of shape variation in the craniofacial skeleton (i...
June 28, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28644430/the-clinical-landscape-for-sma-in-a-new-therapeutic-era
#13
REVIEW
K Talbot, E F Tizzano
Despite significant advances in basic research, the treatment of degenerative diseases of the nervous system remains one of the greatest challenges for translational medicine. The childhood onset motor neuron disorder spinal muscular atrophy (SMA) has been viewed as one of the more tractable targets for molecular therapy, due to a detailed understanding of the molecular genetic basis of the disease. In SMA, inactivating mutations in the SMN1 gene can be partially compensated for by limited expression of SMN protein from a variable number of copies of the SMN2 gene, which provides both a molecular explanation for phenotypic severity and a target for therapy...
June 23, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28643774/insufficient-antibody-validation-challenges-oestrogen-receptor-beta-research
#14
Sandra Andersson, Mårten Sundberg, Nusa Pristovsek, Ahmed Ibrahim, Philip Jonsson, Borbala Katona, Carl-Magnus Clausson, Agata Zieba, Margareta Ramström, Ola Söderberg, Cecilia Williams, Anna Asplund
The discovery of oestrogen receptor β (ERβ/ESR2) was a landmark discovery. Its reported expression and homology with breast cancer pharmacological target ERα (ESR1) raised hopes for improved endocrine therapies. After 20 years of intense research, this has not materialized. We here perform a rigorous validation of 13 anti-ERβ antibodies, using well-characterized controls and a panel of validation methods. We conclude that only one antibody, the rarely used monoclonal PPZ0506, specifically targets ERβ in immunohistochemistry...
June 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28639836/development-of-a-2-dof-uterine-manipulator-with-led-illumination-system-as-a-new-transvaginal-uterus-amputation-device-for-gynecological-surgeries
#15
Serkan Dikici, Betül Aldemir Dikici, Hakan Eser, Erkin Gezgin, Özgün Başer, Savaş Şahin, Bülent Yılmaz, Hakan Oflaz
BACKGROUND: Hysterectomy, the most common major gynecological operation worldwide, consists of removal of the uterus and can be performed abdominally, vaginally, or laparoscopically. A uterine manipulator is a key device used for uterine manipulation and cannulation in hysterectomies. The challenges of conventional manipulators are to move the uterus in two distinct planes and to identify cervical landmarks during circular cut and coagulation. MATERIAL AND METHODS: In this study, a structural synthesis of the two degrees of freedom parallel manipulator was performed considering the constraints noted by surgeons...
June 22, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/28634446/are-distal-and-proximal-visual-cues-equally-important-during-spatial-learning-in-mice-a-pilot-study-of-overshadowing-in-the-spatial-domain
#16
Marie Hébert, Jan Bulla, Denis Vivien, Véronique Agin
Animals use distal and proximal visual cues to accurately navigate in their environment, with the possibility of the occurrence of associative mechanisms such as cue competition as previously reported in honey-bees, rats, birds and humans. In this pilot study, we investigated one of the most common forms of cue competition, namely the overshadowing effect, between visual landmarks during spatial learning in mice. To this end, C57BL/6J × Sv129 mice were given a two-trial place recognition task in a T-maze, based on a novelty free-choice exploration paradigm previously developed to study spatial memory in rodents...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28629678/history-of-electromyography-and-nerve-conduction-studies-a-tribute-to-the-founding-fathers
#17
REVIEW
Mohamed Kazamel, Paula Province Warren
The early development of nerve conduction studies (NCS) and electromyography (EMG) was linked to the discovery of electricity. This relationship had been concluded by observing the effect of applying electricity to the body of an animal and discovering that nerves and muscles themselves could produce electricity. We attempt to review the historical evolution of NCS and EMG over the last three centuries by reviewing the landmark publications of Galvani, Adrian, Denny-Brown, Larrabee, and Lambert. In 1771, Galvani showed that electrical stimulation of animal muscle tissue produced contraction and, thereby, the concept of animal electricity was born...
June 16, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28626470/multi-infarct-dementia-a-historical-perspective
#18
REVIEW
Erin McKay, Scott E Counts
BACKGROUND: Multi-infarct dementia (MID), a prominent subtype of vascular dementia (VaD), has only achieved recognition in the last 4 decades. Since its original description, the characterization, etiological understanding, and therapeutic direction of MID and other VaD subtypes has progressed at an astounding rate. SUMMARY: This paper divides the landmark discoveries and emergence of new research strategies for MID into decade-defining patterns so that a condensed picture of the total history of MID and its eventual inclusion as a VaD subtype emerges...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28622927/evolution-of-the-hominin-knee-and-ankle
#19
Mélanie A Frelat, Colin N Shaw, Simone Sukhdeo, Jean-Jacques Hublin, Stefano Benazzi, Timothy M Ryan
The dispersal of the genus Homo out of Africa approximately 1.8 million years ago (Ma) has been understood within the context of changes in diet, behavior, and bipedal locomotor efficiency. While various morphological characteristics of the knee and ankle joints are considered part of a suite of traits indicative of, and functionally related to, habitual bipedal walking, the timing and phylogenetic details of these morphological changes remain unclear. To evaluate the timing of knee and ankle joint evolution, we apply geometric morphometric methods to three-dimensional digital models of the proximal and distal tibiae of fossil hominins, Holocene Homo sapiens, and extant great apes...
July 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28620458/reproducibility2020-progress-and-priorities
#20
REVIEW
Leonard P Freedman, Gautham Venugopalan, Rosann Wisman
The preclinical research process is a cycle of idea generation, experimentation, and reporting of results. The biomedical research community relies on the reproducibility of published discoveries to create new lines of research and to translate research findings into therapeutic applications. Since 2012, when scientists from Amgen reported that they were able to reproduce only 6 of 53 "landmark" preclinical studies, the biomedical research community began discussing the scale of the reproducibility problem and developing initiatives to address critical challenges...
2017: F1000Research
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