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https://www.readbyqxmd.com/read/28441151/recent-clinical-trials-in-valvular-heart-disease
#1
Daniel Kiss, Saif Anwaruddin
PURPOSE OF REVIEW: With widespread adoption of transcatheter aortic valve replacement, there has been a change in the approach to management of valvular heart disease. New interest has taken hold in transcatheter therapies for valvular heart disease, as well as research into pathophysiology and progression of disease. Additionally, several key trials have further refined our understanding of surgical management of valvular heart disease. This review will elucidate recent clinical trial data leading to changes in practice...
April 24, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28426520/nursing-practice-research-and-education-in-the-west-the-best-is-yet-to-come
#2
Heather M Young, Susan Bakewell-Sachs, Linda Sarna
PURPOSE: This paper celebrates the 60th anniversary of the Western Institute of Nursing, the nursing organization representing 13 states in the Western United States, and envisions a preferred future for nursing practice, research, and education. BACKGROUND: Three landmark calls to action contribute to transforming nursing and healthcare: the Patient Protection and Affordable Care Act of 2010; the Institute of Medicine report Future of Nursing: Leading Change, Advancing Health; and the report Advancing Healthcare Transformation: A New Era for Academic Nursing...
April 20, 2017: Nursing Research
https://www.readbyqxmd.com/read/28418987/the-roles-of-behavioral-and-social-science-research-in-the-fight-against-hiv-aids-a-functional-framework
#3
Paul Gaist, Michael J Stirratt
Landmark advances have been made in HIV/AIDS prevention and treatment. These include proof-of-concept and public health implementation of pre-exposure prophylaxis (PrEP) and "treatment as prevention" (TasP) to reduce HIV transmission as well as definitive evidence of the clinical gain from early antiretroviral treatment (ART) initiation. Significant progress has been made in understanding and addressing the social contexts and behavioral factors that impact HIV prevention, care, and treatment interventions...
April 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28417467/retraction-statement-cxcl12-cxcr4-chemokine-signaling-in-spinal-glia-induces-pain-hypersensitivity-through-mapks-mediated-neuroinflammation-in-bone-cancer-rats
#4
(no author information available yet)
'CXCL12/CXCR4 chemokine signaling in spinal glia induces pain hypersensitivity through MAPKs-mediated neuroinflammation in bone cancer rats' by Hu X.-M., Liu Y.-N., Zhang H.-L., Cao S.-B., Zhang T., Chen L.-P. and Shen W. The above article from Journal of Neurochemistry, published online on 26 January 2015 and in volume 132, issue 4, pages 452-463 (available through www.onlinelibrary.wiley.com), and its subsequent Corrigendum, published online on 5 February 2015 and in volume 132, issue 4, p. 487, have been retracted by agreement between the Journal's Editor-in-Chief, Jörg Schulz, corresponding author Wen Shen on behalf of the authors, and John Wiley & Sons Ltd...
May 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28415862/multivariate-analysis-and-statistics-in-pharmaceutical-process-research-and-development
#5
José E Tabora, Nathan Domagalski
The application of statistics in pharmaceutical process research and development has evolved significantly over the past decades, motivated in part by the introduction of the Quality by Design paradigm, a landmark change in regulatory expectations for the level of scientific understanding associated with the manufacturing process. Today, statistical methods are increasingly applied to accelerate the characterization and optimization of new drugs created via numerous unit operations well known to the chemical engineering discipline...
April 17, 2017: Annual Review of Chemical and Biomolecular Engineering
https://www.readbyqxmd.com/read/28413269/localization-of-epidural-space-a-review-of-available-technologies
#6
REVIEW
Hesham Elsharkawy, Abraham Sonny, Ki Jinn Chin
Although epidural analgesia is widely used for pain relief, it is associated with a significant failure rate. Loss of resistance technique, tactile feedback from the needle, and surface landmarks are traditionally used to guide the epidural needle tip into the epidural space (EDS). The aim of this narrative review is to critically appraise new and emerging technologies for identification of EDS and their potential role in the future. The PubMed, Cochrane Central Register of Controlled Clinical Studies, and Web of Science databases were searched using predecided search strategies, yielding 1048 results...
January 2017: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/28411852/the-molecular-revolution-in-cutaneous-biology-era-of-molecular-diagnostics-for-inherited-skin%C3%A2-diseases
#7
REVIEW
John A McGrath
The discovery of pathogenic mutations in inherited skin diseases represents one of the major landmarks of late 20th century molecular genetics. Mutation data can provide accurate diagnoses, improve genetic counseling, help define disease mechanisms, establish disease models, and provide a basis for translational research and testing of novel therapeutics. The process of detecting disease mutations, however, has not always been straightforward. Traditional approaches using genetic linkage or candidate gene analysis have often been limited, costly, and slow to yield new insights, but the advent of next-generation sequencing (NGS) technologies has altered the landscape of current gene discovery and mutation detection approaches...
May 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28411551/an-alternative-whole-body-marker-set-to-accurately-and-reliably-quantify-joint-kinematics-during-load-carriage
#8
Gavin K Lenton, Tim L A Doyle, David J Saxby, David G Lloyd
Body armor covers anatomical landmarks that would otherwise be used to track trunk and pelvis movement in motion analysis. This study developed and evaluated a new marker set, and compared it to placing markers on the skin and over-top of body armor. In our method, pelvis and trunk motions were measured using a custom-built sacral and upper-back marker cluster, respectively. Joint angles and ranges of motion were determined while participants walked without and with body armor. Angles were obtained from the new marker set and compared against conventional marker sets placed on the skin or over-top the body armor...
April 2, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28393063/neuropsychological-and-psychiatric-outcomes-in-dextro-transposition-of-the-great-arteries-across-the-lifespan-a-state-of-the-art-review
#9
REVIEW
Leila Kasmi, Damien Bonnet, Michèle Montreuil, David Kalfa, Nikoletta Geronikola, David C Bellinger, Johanna Calderon
Advances in prenatal diagnosis, perioperative management, and postoperative care have dramatically increased the population of survivors of neonatal and infant heart surgery. The high survival rate of these patients into adulthood has exposed the alarming prevalence of long-term neuropsychological and psychiatric morbidities. Dextro-transposition of the great arteries (d-TGA) is one of the most extensively studied cyanotic congenital heart defect (CHD) with regard to neurodevelopmental outcomes. Landmark studies have described a common neurodevelopmental and behavioral phenotype associated with d-TGA...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28388941/prediction-of-the-optimal-depth-for-superior-vena-cava-cannulae-with-cardiac-computed-tomography-during-minimally-invasive-cardiac-surgery-a-prospective-observational-cohort-study
#10
Ji-Hyun Chin, Eun-Ho Lee, Jong-Il Kim, In-Cheol Choi
BACKGROUND: The determination of the adequate depth of superior vena cava cannulae during minimally invasive cardiac surgery is important for warranting venous drainage and preventing complications during cardiopulmonary bypass. We investigated whether preoperative cardiac computed tomography might be useful for predicting the optimal depth of superior vena cava cannulae. METHODS: The patients who required superior vena cava cannulation and had cardiac tomographic image among those scheduled to undergo a minimally invasive cardiac surgery were evaluated...
April 7, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28388542/emerging-proteomics-biomarkers-and-prostate-cancer-burden-in-africa
#11
REVIEW
Henry A Adeola, Jonathan M Blackburn, Timothy R Rebbeck, Luiz F Zerbini
Various biomarkers have emerged via high throughput omics-based approaches for use in diagnosis, treatment, and monitoring of prostate cancer. Many of these have yet to be demonstrated as having value in routine clinical practice. Moreover, there is a dearth of information on validation of these emerging prostate biomarkers within African cohorts, despite the huge burden and aggressiveness of prostate cancer in men of African descent. This review focusses of the global landmark achievements in prostate cancer proteomics biomarker discovery and the potential for clinical implementation of these biomarkers in Africa...
March 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28367498/how-sense-of-direction-and-learning-intentionality-relate-to-spatial-knowledge-acquisition-in-the-environment
#12
Heather Burte, Daniel R Montello
People's impression of their own "sense-of-direction" (SOD) is related to their ability to effectively find their way through environments, such as neighborhoods and cities, but is also related to the speed and accuracy with which they learn new environments. In the current literature, it is unclear whether the cognitive skills underlying SOD require intentional cognitive effort to produce accurate knowledge of a new environment. The cognitive skills underlying SOD could exert their influence automatically-without conscious intention-or they might need to be intentionally and effortfully applied...
2017: Cognitive Research: Principles and Implications
https://www.readbyqxmd.com/read/28364486/genetic-basis-of-chronotype-in-humans-insights-from-three-landmark-gwas
#13
David A Kalmbach, Logan D Schneider, Joseph Cheung, Sarah J Bertrand, Thiruchelvam Kariharan, Allan I Pack, Philip R Gehrman
Study Objectives: Chronotype, or diurnal preference, refers to behavioral manifestations of the endogenous circadian system that governs preferred timing of sleep and wake. As variations in circadian timing and system perturbations are linked to disease development, the fundamental biology of chronotype has received attention for its role in the regulation and dysregulation of sleep and related illnesses. Family studies indicate that chronotype is a heritable trait, thus directing attention toward its genetic basis...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28362894/occipitocervical-instability-after-far-lateral-transcondylar-surgery-a-biomechanical-analysis
#14
Marcus D Mazur, William T Couldwell, Aaron Cutler, Lubdha M Shah, Darrel S Brodke, Kent Bachus, Andrew T Dailey
BACKGROUND: After a far-lateral transcondylar approach, patients may maintain neutral alignment in the immediate postoperative period, but severe occipitoatlantal subluxation may occur gradually with cranial settling and possible neurological injury. Previous research is based on assumptions regarding the extent of condylar resection and the change in biomechanics that produces instability. OBJECTIVE: To quantify the extent of bone removal during a far-lateral transcondylar approach, determine the changes in range of motion (ROM) and stiffness that occur after condylar resection, and identify the threshold of condylar resection that predicts alterations in occipitocervical biomechanics...
January 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28351758/the-mouse-cortical-meninges-are-the-site-of-immune-responses-to-many-different-pathogens-and-are-accessible-to-in-vivo-imaging
#15
REVIEW
Jonathan A Coles, Phillip J Stewart-Hutchinson, Elmarie Myburgh, James M Brewer
A wide range of viral and microbial infections are known to cause meningitis, and there is evidence that the meninges are the gateway to pathogenic invasion of the brain parenchyma. Hence observation of these regions has wide application to understanding host-pathogen interactions. Interactions between pathogens and cells of the immune response can be modified by changes in their environment, such as suppression of the flow of blood and lymph, and, particularly in the case of the meninges with their unsupported membranes, invasive dissection can alter the tissue architecture...
March 25, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28349911/evaluation-of-soft-tissue-landmark-reliability-between-manual-and-computerized-plotting-methods
#16
Geetha Kasinathan, Pradeep B Kommi, Senthil M Kumar, Aniruddh Yashwant, Nandakumar Arani, Senkutvan Sabapathy
AIM: The aim of the study is to evaluate the reliability of soft tissue landmark identification between manual and digital plot-tings in both X and Y axes. MATERIALS AND METHODS: A total of 50 pretreatment lateral cephalograms were selected from patients who reported for orthodontic treatment. The digital images of each cephalogram were imported directly into Dolphin software for onscreen digi-talization, while for manual tracing, images were printed using a compatible X-ray printer...
April 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28347863/common-bean-proteomics-present-status-and-future-strategies
#17
Sajad Majeed Zargar, Reetika Mahajan, Muslima Nazir, Preeti Nagar, Sun Tae Kim, Vandna Rai, Antonio Masi, Syed Mudasir Ahmad, Riaz Ahmad Shah, Nazir Ahmad Ganai, Ganesh K Agrawal, Randeep Rakwal
Common bean (Phaseolus vulgaris L.) is a legume of appreciable importance and usefulness worldwide to the human population providing food and feed. It is rich in high-quality protein, energy, fiber and micronutrients especially iron, zinc, and pro-vitamin A; and possesses potentially disease-preventing and health-promoting compounds. The recently published genome sequence of common bean is an important landmark in common bean research, opening new avenues for understanding its genetics in depth. This legume crop is affected by diverse biotic and abiotic stresses severely limiting its productivity...
March 24, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28335555/activity-recognition-and-semantic-description-for-indoor-mobile-localization
#18
Sheng Guo, Hanjiang Xiong, Xianwei Zheng, Yan Zhou
As a result of the rapid development of smartphone-based indoor localization technology, location-based services in indoor spaces have become a topic of interest. However, to date, the rich data resulting from indoor localization and navigation applications have not been fully exploited, which is significant for trajectory correction and advanced indoor map information extraction. In this paper, an integrated location acquisition method utilizing activity recognition and semantic information extraction is proposed for indoor mobile localization...
March 21, 2017: Sensors
https://www.readbyqxmd.com/read/28328064/a-bibliometric-analysis-of-pediatric-liver-transplantation-publications
#19
Dermot T McDowell, Alexandre Darani, Albert Shun, Gordon Thomas, Andrew J A Holland
Citation counts can identify landmark papers. The aim of this study was to identify and characterize the top-cited articles in the pediatric liver transplantation literature. A search strategy for the Scopus(®) database was designed for pediatric liver transplantation publications from 1945 to 2014. The 50 top-cited articles were analyzed. Author co-citation analysis was performed using VOSviewer techniques. There were 2896 articles published between 1969 and 2015. The mean citation count of the top 50 cited articles was 166 (range 95-635)...
March 22, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28319004/updated-risk-factors-should-be-used-to-predict-development-of-diabetes
#20
Mary Angelyn Bethel, Kristen A Hyland, Antonio R Chacra, Prakash Deedwania, Gregory R Fulcher, Rury R Holman, Trond Jenssen, Naomi S Levitt, John J V McMurray, Eleni Boutati, Laine Thomas, Jie-Lena Sun, Steven M Haffner
AIMS: Predicting incident diabetes could inform treatment strategies for diabetes prevention, but the incremental benefit of recalculating risk using updated risk factors is unknown. We used baseline and 1-year data from the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) Trial to compare diabetes risk prediction using historical or updated clinical information. METHODS: Among non-diabetic participants reaching 1year of follow-up in NAVIGATOR, we compared the performance of the published baseline diabetes risk model with a "landmark" model incorporating risk factors updated at the 1-year time point...
May 2017: Journal of Diabetes and its Complications
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