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https://www.readbyqxmd.com/read/28079633/criterion-referenced-values-of-grip-strength-and-usual-gait-speed-using-instrumental-activities-of-daily-living-disability-as-the-criterion
#1
Meng-Chih Lee, Chih-Cheng Hsu, Yi-Fen Tsai, Ching-Yu Chen, Cheng-Chieh Lin, Ching-Yi Wang
BACKGROUND AND PURPOSE: Current evidence suggests that grip strength and usual gait speed (UGS) are important predictors of instrumental activities of daily living (IADL) disability. Knowing the optimum cut points of these tests for discriminating people with and without IADL disability could help clinicians or researchers to better interpret the test results and make medical decisions. The purpose of this study was to determine the cutoff values of grip strength and UGS for best discriminating community-dwelling older adults with and without IADL disability, separately for men and women, and to investigate their association with IADL disability...
January 10, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28070686/turn-left-where-you-felt-unhappy-how-affect-influences-landmark-based-wayfinding
#2
Ceylan Z Balaban, Harun Karimpur, Florian Röser, Kai Hamburger
The present work investigated the impact of affect in landmark-based wayfinding. We assumed that affect-laden landmarks improve wayfinding performance and have an impact on later landmark recognition. To investigate our hypotheses, we ran two experiments in a virtual maze. In Experiment 1, we investigated how affect-laden landmarks influence wayfinding and recognition in comparison with neutral landmarks. The aim of Experiment 2 was to focus on the affective valence of a landmark. The memory tasks of both experiments were repeated after 1 week in order to assess memory consolidation...
January 9, 2017: Cognitive Processing
https://www.readbyqxmd.com/read/28065299/labeling-membrane-domains-in-dividing-echinoderm-eggs
#3
M Bennett, J Meaders, S Ruvolo, D Burgess
Sea urchins have long been used as a model organism to address questions in cell biology and development. Work utilizing this model has elucidated processes of fertilization, the description of centrosomes, the separation of chromosomes during mitosis, and numerous other landmark discoveries. They have been a favorite among researchers for a variety of reasons: Eggs are large and malleable, making them relatively easy to work with; the embryos have synchronized, rapid divisions; they are easy to microinject and manipulate; and their genome sequence is available...
2017: Methods in Cell Biology
https://www.readbyqxmd.com/read/28062516/systems-thinking-in-public-health-a-bibliographic-contribution-to-a-meta-narrative-review
#4
Saad Chughtai, Karl Blanchet
BACKGROUND: Research across the formal, natural and social sciences has greatly expanded our knowledge about complex systems in recent decades, informing a broadly inclusive, cross-disciplinary conceptual framework referred to as Systems Thinking (ST). Its use in public health is rapidly increasing, although there remains a poor understanding of how these ideas have been imported, adapted and elaborated by public health research networks worldwide. METHOD: This review employed a mixed methods approach to narrate the development of ST in public health...
January 6, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28057260/a-renaissance-in-nepovirus-research-provides-new-insights-into-their-molecular-interface-with-hosts-and-vectors
#5
REVIEW
M Fuchs, C Schmitt-Keichinger, H Sanfaçon
Nepoviruses supplied seminal landmarks to the historical trail of plant virology. Among the first agriculturally relevant viruses recognized in the late 1920s and among the first plant viruses officially classified in the early 1970s, nepoviruses also comprise the first species for which a soil-borne ectoparasitic nematode vector was identified. Early research on nepoviruses shed light on the genome structure and expression, biological properties of the two genomic RNAs, and mode of transmission. In recent years, research on nepoviruses enjoyed an extraordinary renaissance...
2017: Advances in Virus Research
https://www.readbyqxmd.com/read/28048467/su-g-jep2-08-image-guided-radiation-therapy-using-synthetic-cts-in-brain-cancer
#6
R G Price, J Kim, W Zheng, I J Chetty, C Glide-Hurst
PURPOSE: Synthetic-CTs(synCTs) are essential for MR-only treatment planning. However, the performance of synCT for IGRT must be carefully assessed. This work evaluated the accuracy of synCT and synCT-generated DRRs and determined their performance for IGRT in brain cancer radiation therapy. METHODS: MR-SIM and CT-SIM images were acquired of a novel anthropomorphic phantom and a cohort of 12 patients. SynCTs were generated by combining an ultra-short echo time (UTE) sequence with other MRI datasets using voxel-based weighted summation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048364/we-fg-207a-01-introduction-to-dedicated-breast-ct-early-studies
#7
S Vedantham
: Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047870/tu-h-campus-tep2-03-high-sensitivity-and-high-resolution-fiber-based-micro-detector-for-sub-millimeter-preclinical-dosimetry
#8
E Izaguirre, S Pokhrel, S Hedrick, T Knewtson
PURPOSE: Current precision of small animal and cell micro-irradiators has continuously increased during the past years. Currently, preclinical irradiators can deliver sub-millimeter fields with micrometric precision but there are no water equivalent dosimeters to determine small field profiles and dose in the orthovoltage range of energies with micrometric resolution and precision. We have developed a fiber based micro-dosimeter with the resolution and dosimetric accuracy required for radiobiological research...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047717/we-fg-207a-02-why-we-need-breast-ct-clinical-perspective
#9
A O'Connell
: Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047661/su-f-j-180-a-reference-data-set-for-testing-two-dimension-registration-algorithms
#10
A Dankwa, E Castillo, T Guerrero
PURPOSE: To create and characterize a reference data set for testing image registration algorithms that transform portal image (PI) to digitally reconstructed radiograph (DRR). METHODS: Anterior-posterior (AP) and Lateral (LAT) projection and DRR image pairs from nine cases representing four different anatomical sites (head and neck, thoracic, abdominal, and pelvis) were selected for this study. Five experts will perform manual registration by placing landmarks points (LMPs) on the DRR and finding their corresponding points on the PI using computer assisted manual point selection tool (CAMPST), a custom-made MATLAB software tool developed in house...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047520/we-fg-207a-05-dedicated-breast-ct-as-a-diagnostic-imaging-tool-physics-and-clinical-feasibility
#11
A Karellas
: Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047262/tu-h-campus-iep3-03-validation-of-image-registration-methods-for-brain-magnetic-resonance-imaging
#12
J Lin, D Fuentes, A Chandler, J Hazle, D Schellingerhout, C MacLellan
PURPOSE: To assess the performance of both commercial and open-source co-registration solutions as applied to intra-subject, multi-sequence, magnetic resonance (MR) images of the brain. METHODS: Twenty (20) patients were imaged on clinical 3.0T MR scanners to obtain T2-weighted (T2W), fluid attenuation inversion recovery (FLAIR), susceptibility weighted angiography (SWAN), and T1 post-contrast (T1C) image sequences. Fiducial landmark sites (n=15 per sequence, 4 sequences per patient, 1200 total planned for 4 sequences and 20 patients, 1175 total realized) were specified throughout these image volumes to define identical locations across sequences...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047089/th-cd-206-05-machine-learning-based-segmentation-of-organs-at-risks-for-head-and-neck-radiotherapy-planning
#13
B Ibragimov, F Pernus, P Strojan, L Xing
PURPOSE: Accurate and efficient delineation of tumor target and organs-at-risks is essential for the success of radiotherapy. In reality, despite of decades of intense research efforts, auto-segmentation has not yet become clinical practice. In this study, we present, for the first time, a deep learning-based classification algorithm for autonomous segmentation in head and neck (HaN) treatment planning. METHODS: Fifteen HN datasets of CT, MR and PET images with manual annotation of organs-at-risk (OARs) including spinal cord, brainstem, optic nerves, chiasm, eyes, mandible, tongue, parotid glands were collected and saved in a library of plans...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047068/we-fg-207a-03-low-dose-cone-beam-breast-ct-physics-and-technology-development
#14
J Boone
: Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047060/su-c-209-02-3d-fluoroscopic-image-generation-from-patient-specific-4dcbct-based-motion-models-derived-from-clinical-patient-images
#15
S Dhou, D Ionascu, W Cai, M Hurwitz, C Williams, J Lewis
PURPOSE: We develop a method to generate time varying volumetric images (3D fluoroscopic images) using patient-specific motion models derived from four-dimensional cone-beam CT (4DCBCT). METHODS: Motion models are derived by selecting one 4DCBCT phase as a reference image, and registering the remaining images to it. Principal component analysis (PCA) is performed on the resultant displacement vector fields (DVFs) to create a reduced set of PCA eigenvectors that capture the majority of respiratory motion...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046803/mo-ab-bra-09-development-and-evaluation-of-a-biomechanical-modeling-assisted-cbct-reconstruction-technique-bio-recon
#16
Y Zhang, J Nasehi Tehrani, J Wang
PURPOSE: To develop a Bio-recon technique by incorporating the biomechanical properties of anatomical structures into the deformation-based CBCT reconstruction process. METHODS: Bio-recon reconstructs the CBCT by deforming a prior high-quality CT/CBCT using a deformation-vector-field (DVF). The DVF is solved through two alternating steps: 2D-3D deformation and finite-element-analysis based biomechanical modeling. 2D-3D deformation optimizes the DVF through an 'intensity-driven' approach, which updates the DVF to minimize intensity mismatches between the acquired projections and the simulated projections from the deformed CBCT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046653/tu-ab-bra-05-optimization-of-a-novel-large-field-of-view-distortion-phantom-for-mr-only-treatment-planning
#17
R G Price, R A Knight, K Hwang, E Bayram, C Glide-Hurst
PURPOSE: MR-only treatment planning requires images of high geometric fidelity, particularly for large fields of view (FOV). However, the availability of large FOV distortion phantoms with accompanying analysis software is currently limited to in-house solutions. This work sought to optimize the design of a modular distortion phantom that can accommodate several bore configurations and implement distortion corrections. METHODS: 1.0T MR and CT images were acquired of twelve urethane foam samples of various densities and strengths...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046408/we-fg-207a-04-performance-characteristics-of-photon-counting-breast-ct
#18
W Kalender
: Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046291/we-fg-207a-00-advances-in-dedicated-breast-ct
#19
Srinivasan Vedantham, Sabee Molloi
: Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28030896/cancer-metabolism-fueling-more-than-just-growth
#20
REVIEW
Namgyu Lee, Dohoon Kim
The early landmark discoveries in cancer metabolism research have uncovered metabolic processes that support rapid proliferation, such as aerobic glycolysis (Warburg effect), glutaminolysis, and increased nucleotide biosynthesis. However, there are limitations to the effectiveness of specifically targeting the metabolic processes which support rapid proliferation. First, as other normal proliferative tissues also share similar metabolic features, they may also be affected by such treatments. Secondly, targeting proliferative metabolism may only target the highly proliferating "bulk tumor" cells and not the slower-growing, clinically relevant cancer stem cell subpopulations which may be required for an effective cure...
December 2016: Molecules and Cells
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