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Zika and pregnancy

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https://www.readbyqxmd.com/read/28429036/a-review-of-zika-virus-infections-in-pregnancy-and-implications-for-antenatal-care-in-singapore
#1
Harvard Zhenjia Lin, Paul Anantharajah Tambyah, Eu Leong Yong, Arijit Biswas, Shiao-Yng Chan
Given the consensus that there is a causal relationship between Zika virus (ZIKV) infection in pregnancy and congenital Zika syndrome (CZS), clinicians must be prepared to manage affected patients despite the numerous gaps in current knowledge. The clinical course in pregnancy appears similar to that in non-pregnant women, although viraemia may be prolonged. ZIKV infection can be diagnosed by serum and urine reverse transcription-polymerase chain reaction, but commercially available serological tests are currently unreliable in dengue-endemic regions...
April 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28428164/zika-in-twitter-temporal-variations-of-locations-actors-and-concepts
#2
Anthony Stefanidis, Emily Vraga, Georgios Lamprianidis, Jacek Radzikowski, Paul L Delamater, Kathryn H Jacobsen, Dieter Pfoser, Arie Croitoru, Andrew Crooks
BACKGROUND: The recent Zika outbreak witnessed the disease evolving from a regional health concern to a global epidemic. During this process, different communities across the globe became involved in Twitter, discussing the disease and key issues associated with it. This paper presents a study of this discussion in Twitter, at the nexus of location, actors, and concepts. OBJECTIVE: Our objective in this study was to demonstrate the significance of 3 types of events: location related, actor related, and concept related, for understanding how a public health emergency of international concern plays out in social media, and Twitter in particular...
April 20, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28421065/zika-virus-infection-during-pregnancy-and-congenital-abnormalities
#3
REVIEW
Irfan A Rather, Jameel B Lone, Vivek K Bajpai, Yong-Ha Park
The presence of the Zika virus (ZIKV) infection has gone ahead to be a threat to people based on its adverse impacts. More specifically, the pregnant women have been discouraged from traveling to the areas affected by the ZIKV because of the likelihood of the virus causing congenital abnormalities especially the microcephaly. The pregnant women probably attracted the virus during their first trimester while visiting ZIKV affected territories. Although the ZIKV infected cases have reduced in some parts of countries, the global risk assessment has not been changed...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28418539/ophthalmic-manifestations-of-congenital-zika-syndrome-in-colombia-and-venezuela
#4
Juan B Yepez, Felipe A Murati, Michele Pettito, Carlos F Peñaranda, Jazmin de Yepez, Gladys Maestre, J Fernando Arevalo
Importance: The ocular manifestations and sequelae of Zika virus infection are not well known. Recently, the World Health Organization changed the declaration of Zika as a public health emergency and designated the viral outbreak and related microcephaly clusters as a long-term program of work. This change indicates the urgent need to evaluate and document ophthalmic manifestations in patients for timely management of this disease. In addition, confirmation whether the public health problem in Brazil extends to other regions in South America is needed...
April 13, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28410349/zika-virus-and-assisted-reproduction
#5
Christina N Cordeiro, Rashda Bano, Chantel I Washington Cross, James H Segars
PURPOSE OF REVIEW: Due to the fact that the Zika virus can be sexually transmitted, there is a potential risk for disease transmission at several stages of assisted reproduction. Such a possibility poses a serious challenge to couples pursing fertility with reproductive technologies. Here, we discuss what is known regarding Zika virus infection with respect to sexual transmission and correlate this knowledge with recent recommendations in the realm of infertility treatment. RECENT FINDINGS: Zika virus can be transmitted from infected men and women through vaginal, oral or anal intercourse...
April 12, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28409618/zika-virus-common-questions-and-answers
#6
Irogue I Igbinosa, Ingrid B Rabe, Titilope Oduyebo, Sonja A Rasmussen
Since local mosquito-borne transmission of Zika virus was first reported in Brazil in early 2015, the virus has spread rapidly, with active transmission reported in at least 61 countries and territories worldwide, including the United States. Zika virus infection during pregnancy is a cause of microcephaly and other severe brain anomalies. The virus is transmitted primarily through the bite of an infected Aedes mosquito, but other routes of transmission include sexual, mother-to-fetus during pregnancy, mother-to-infant at delivery, laboratory exposure, and, possibly, transfusion of blood products...
April 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28402153/maternal-fetal-transmission-of-zika-virus-routes-and-signals-for-infection
#7
Bin Cao, Michael S Diamond, Indira U Mysorekar
The emerging mosquito-borne virus, Zika virus (ZIKV), has been causally associated with adverse pregnancy and neonatal outcomes, including miscarriage, microcephaly, serious brain abnormalities, and other birth defects indicative of a congenital ZIKV syndrome. In this review, we highlight work from human and animal studies on routes of infection in pregnancy that lead to adverse fetal and neonatal outcomes. A number of innate and adaptive immune mechanisms and signaling molecules that may have key roles in ZIKV infection pathogenesis are discussed along with putative viral entry pathways...
April 12, 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28399888/a-guinea-pig-model-of-zika-virus-infection
#8
Mukesh Kumar, Keeton K Krause, Francine Azouz, Eileen Nakano, Vivek R Nerurkar
BACKGROUND: Animal models are critical to understand disease and to develop countermeasures for the ongoing epidemic of Zika virus (ZIKV). Here we report that immunocompetent guinea pigs are susceptible to infection by a contemporary American strain of ZIKV. METHODS: Dunkin-Hartley guinea pigs were inoculated with 10(6) plaque-forming units of ZIKV via subcutaneous route and clinical signs were observed. Viremia, viral load in the tissues, anti-ZIKV neutralizing antibody titer, and protein levels of multiple cytokine and chemokines were analyzed using qRT-PCR, plaque assay, plaque reduction neutralization test (PRNT) and multiplex immunoassay...
April 11, 2017: Virology Journal
https://www.readbyqxmd.com/read/28398684/studying-the-effects-of-emerging-infections-on-the-fetus-experience-with-west-nile-and-zika-viruses
#9
Sonja A Rasmussen, Dana M Meaney-Delman, Lyle R Petersen, Denise J Jamieson
Emerging infections have the potential to produce adverse effects on the pregnant woman or her fetus; however, studying these effects is often challenging. We review our experiences with investigating the prenatal effects of two mosquito-borne infections that emerged in the past 2 decades, West Nile virus (WNV) and Zika virus. Concerns regarding teratogenicity were raised about both viruses; Zika virus has been confirmed to be teratogenic, while WNV appears not to increase the risk for adverse outcomes, although teratogenicity has not been excluded...
March 15, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28398681/population-based-pregnancy-and-birth-defects-surveillance-in-the-era-of-zika-virus
#10
Suzanne M Gilboa, Cara T Mai, Carrie K Shapiro-Mendoza, Janet D Cragan, Cynthia A Moore, Dana M Meaney-Delman, Denise J Jamieson, Margaret A Honein, Coleen A Boyle
BACKGROUND: Zika virus is a newly recognized human teratogen; monitoring its impact on the birth prevalence of microcephaly and other adverse pregnancy outcomes will continue to be an urgent need in the United States and worldwide. METHODS: When the Centers for Disease Control and Prevention (CDC) activated the Emergency Operations Center for the Zika virus outbreak response in January of 2016, public health leadership recognized that a joint, coordinated effort was required between activities focused on the effects of the infection among pregnant women and those focused on birth defects in fetuses and infants...
March 15, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28398676/treatment-of-infections-during-pregnancy-progress-and-challenges
#11
REVIEW
Lisa M Noguchi, Richard H Beigi
BACKGROUND: Emergence of Zika virus as a pathogen with important implications for perinatal outcomes highlights the need to identify safe and effective strategies for prevention and treatment of maternal infections. METHODS: While substantial progress has been made in this area in recent years, significant regulatory and health systems barriers must still be overcome to identify and deliver evidence-based drug therapies for pregnant women. RESULTS: We review progress and outstanding challenges associated with the identification and implementation of new treatment options for maternal infections...
March 15, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28393598/-zika-virus-infection-in-pregnancy
#12
Gabriella Varjasi, Róbert Póka
The Zika virus is a flavivirus spread by mosquitoes. Its primary vectors are the Aedes aegypti and the Aedes albopictus. Before 2007 it sporadically caused benign morbidity. Since 2015, it started spreading "explosively" in America, especially in Brazil. In August 2016 they reported cases from New York and Poland, too. Most of the infections don't produce any symptoms, but can cause grave complications. The most important lesion is microcephalia that forms in fetuses. Microcephalia's most serious consequence is mental retardation, which puts great burden on both the family and the society...
April 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28390691/zika-virus-detected-in-amniotic-fluid-and-umbilical-cord-blood-in-an-in%C3%A2-vitro-fertilization-conceived-pregnancy-in-venezuela
#13
Isaac Benjamin, Gissel Fernández, José Valentin Figueira, Leticia Parpacén, María Teresa Urbina, Randolfo Medina
OBJECTIVE: To describe the consequences of Zika virus infection at 10 weeks of gestation in an IVF-conceived pregnancy in Venezuela. DESIGN: A case report. SETTING: Private assisted reproduction unit. PATIENT(S): A 36-year-old patient who conceived her first pregnancy through IVF and became infected with Zika virus at 10 weeks' gestation in Venezuela. INTERVENTION(S): In vitro fertilization with fresh ET...
April 6, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28384133/vital-signs-update-on-zika-virus-associated-birth-defects-and-evaluation-of-all-u-s-infants-with-congenital-zika-virus-exposure-u-s-zika-pregnancy-registry-2016
#14
Megan R Reynolds, Abbey M Jones, Emily E Petersen, Ellen H Lee, Marion E Rice, Andrea Bingham, Sascha R Ellington, Nicole Evert, Sarah Reagan-Steiner, Titilope Oduyebo, Catherine M Brown, Stacey Martin, Nina Ahmad, Julu Bhatnagar, Jennifer Macdonald, Carolyn Gould, Anne D Fine, Kara D Polen, Heather Lake-Burger, Christina L Hillard, Noemi Hall, Mahsa M Yazdy, Karnesha Slaughter, Jamie N Sommer, Alys Adamski, Meghan Raycraft, Shannon Fleck-Derderian, Jyoti Gupta, Kimberly Newsome, Madelyn Baez-Santiago, Sally Slavinski, Jennifer L White, Cynthia A Moore, Carrie K Shapiro-Mendoza, Lyle Petersen, Coleen Boyle, Denise J Jamieson, Dana Meaney-Delman, Margaret A Honein
BACKGROUND: In collaboration with state, tribal, local, and territorial health departments, CDC established the U.S. Zika Pregnancy Registry (USZPR) in early 2016 to monitor pregnant women with laboratory evidence of possible recent Zika virus infection and their infants. METHODS: This report includes an analysis of completed pregnancies (which include live births and pregnancy losses, regardless of gestational age) in the 50 U.S. states and the District of Columbia (DC) with laboratory evidence of possible recent Zika virus infection reported to the USZPR from January 15 to December 27, 2016...
April 7, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28375541/unravelling-the-paediatric-and-perinatal-zika-virus-epidemic-through-population-based-research
#15
Cdc Christie, C Giaquinto
Zika virus epidemic now involves 72 countries, worldwide. Transmission is multimodal through mosquito bites and blood and body fluids. Zika virus causes Guillain Barre Syndrome syndrome and pregnancy complications including perinatal microcephaly. Diagnosis is complicated by subclinical infection in 80%, co-circulation with dengue and chikungunya fevers with similar presentations and cross-reactivity in serological tests. There is no cure, or preventive vaccine. Large population-based studies will help to elucidate ZIKV epidemiology, vertical transmission, risks to the fetus of maternal ZIKV infection and natural history of congenital and non-congenital ZIKV infection as provided by the activities in the "ZIKAction" research consortium in Latin America, Europe and the Caribbean, which was recently funded by the European Commission...
September 19, 2016: West Indian Medical Journal
https://www.readbyqxmd.com/read/28372356/zika-virus-on-youtube-an-analysis-of-english-language-video-content-by-source
#16
Corey H Basch, Isaac Chun-Hai Fung, Rodney N Hammond, Elizabeth B Blankenship, Zion Tsz Ho Tse, King-Wa Fu, Patrick Ip, Charles E Basch
OBJECTIVES: The purpose of this study was to describe the source, length, number of views, and content of the most widely viewed Zika virus (ZIKV)-related YouTube videos. We hypothesized that ZIKV-related videos uploaded by different sources contained different content. METHODS: The 100 most viewed English ZIKV-related videos were manually coded and analyzed statistically. RESULTS: Among the 100 videos, there were 43 consumer-generated videos, 38 Internet-based news videos, 15 TV-based news videos, and 4 professional videos...
March 2017: Journal of Preventive Medicine and Public Health, Yebang Ŭihakhoe Chi
https://www.readbyqxmd.com/read/28370966/zika-infection-and-the-development-of-neurological-defects
#17
REVIEW
Fabiele Baldino Russo, Patricia Jungmann, Patricia Cristina Baleeiro Beltrão-Braga
Starting with the outbreak in Brazil, Zika virus (ZIKV) infection has been correlated with severe syndromes such as Congenital Zika Syndrome (CZS) and Guillain- Barré Syndrome (GBS). Here we review the status of Zika virus pathogenesis in the central nervous system (CNS). One of the main concerns about ZIKV exposure during pregnancy is abnormal brain development, which results in microcephaly in newborns. Recent advances in in vitro research show that ZIKV can infect and obliterate cells from the CNS, such as progenitors, neurons, and glial cells...
March 31, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28358795/zika-virus-transmission-region-of-the-americas-may-15-2015-december-15-2016
#18
Juniorcaius Ikejezie, Craig N Shapiro, Jisoo Kim, Monica Chiu, Maria Almiron, Ciro Ugarte, Marcos A Espinal, Sylvain Aldighieri
Zika virus, a mosquito-borne flavivirus that can cause rash with fever, emerged in the Region of the Americas on Easter Island, Chile, in 2014 and in northeast Brazil in 2015 (1). In response, in May 2015, the Pan American Health Organization (PAHO), which serves as the Regional Office of the Americas for the World Health Organization (WHO), issued recommendations to enhance surveillance for Zika virus. Subsequently, Brazilian investigators reported Guillain-Barré syndrome (GBS), which had been previously recognized among some patients with Zika virus disease, and identified an association between Zika virus infection during pregnancy and congenital microcephaly (2)...
March 31, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28352303/paediatric-virology-a-rapidly-increasing-educational-challenge
#19
Ioannis N Mammas, Maria Theodoridou, Anna Kramvis, Prakash Thiagarajan, Sharryn Gardner, Georgia Papaioannou, Angeliki Melidou, Maria Koutsaki, Georgia Kostagianni, Vassilis Achtsidis, Chryssie Koutsaftiki, Marcos Calachanis, Apostolos Zaravinos, Anne Greenough, Demetrios A Spandidos
The '2nd Workshop on Paediatric Virology', which took place on Saturday the 8th of October 2016 in Athens, Greece, provided an overview on recent views and advances on Paediatric Virology. Emphasis was given to HIV-1 management in Greece, a country under continuous financial crisis, hepatitis B vaccination in Africa, treatment options for hepatitis C virus in childhood, Zika virus in pregnancy and infancy, the burden of influenza on childhood, hand-foot-mouth disease and myocarditis associated with Coxsackie viruses...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28343414/zika-virus-and-pregnant-women-a-psychological-approach
#20
Juliana Fernandes Filgueiras Meireles, Clara Mockdece Neves, Fabiane Frota da Rocha Morgado, Maria Elisa Caputo Ferreira
Zika virus presents risk of physical harm to pregnant women, but the fear of infection is also affecting women around the world. There is a gap in the research on Zika virus in the areas involving the impact on the psychosocial well-being of pregnant women. Therefore, this study is aimed at the investigation of the psychosocial adjustment of pregnant women to the risks of Zika virus infection during pregnancy. We investigated 14 pregnant women who were classified in three different groups: six in the first trimester, five in the second trimester and three in the third trimester, aged from 28 to 40 years (33...
March 27, 2017: Psychology & Health
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