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https://www.readbyqxmd.com/read/28925940/zebrafish-as-a-model-for-the-study-of-microvascular-complications-of-diabetes-and-their-mechanisms
#1
REVIEW
Karl Heckler, Jens Kroll
Diabetes mellitus (DM) is a crucial metabolic disease that leads to severe disorders. These include macrovascular complications such as myocardial infarction, stroke, and peripheral artery disease and microvascular complications including diabetic nephropathy, neuropathy, and retinopathy. Diabetes mellitus, along with its associated organ pathologies, is one of the key problems in today's medicine. Zebrafish is an upcoming disease model organism in diabetes research. Its glucose metabolism and the pathways of reactive metabolite formation are very similar to those of humans...
September 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28923179/drugs-and-hyperglycemia-a-practical-guide
#2
REVIEW
Vandana Jain, Ronak Kumar Patel, Zaureen Kapadia, Sneha Galiveeti, Maryann Banerji, Lisel Hope
Drug-induced diabetes is one of the factors contributing to the increasing incidence of diabetes worldwide. This review considers the frequency, pathogenesis and treatment of drug-induced diabetes. Drugs that induce diabetes include hormonal therapy, especially glucocorticoids and androgen blockers, cardiovascular drugs, especially statins, beta-blockers and diuretics, antipsychotics, especially clozapine, olanzapine and quetiapine, antiretrovirals (protease inhibitors and non-reverse transcriptase inhibitors - NRTIs) and other drugs (mechanistic target of rapamycin inhibitors -mTORs, post organ transplantation drugs, tyrosine kinase inhibitors and interferon-alpha)...
October 2017: Maturitas
https://www.readbyqxmd.com/read/28921256/relation-between-different-measures-of-glycemic-exposure-and-microvascular-and-macrovascular-complications-in-patients-with-type-2-diabetes-mellitus-an-observational-cohort-study
#3
Rients P T van Wijngaarden, Jetty A Overbeek, Edith M Heintjes, Agata Schubert, Joris Diels, Huub Straatman, Ewout W Steyerberg, Ron M C Herings
INTRODUCTION: This retrospective cohort study investigated the relation between different measures of glycemic exposure and micro- and macrovascular complications among patients with type 2 diabetes. METHODS: The analysis included patients receiving oral antihyperglycemic agents between 1 January 2006 and 31 December 2014 from the General Practitioner Database from the PHARMO Database Network. All recorded HbA1c levels during follow-up were used to express glycemic exposure in four ways: index HbA1c, time-dependent HbA1c, exponential moving average (EMA) and glycemic burden...
September 18, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28917022/epidemiology-pathogenesis-and-management-of-takotsubo-syndrome
#4
REVIEW
Shams Y-Hassan, Per Tornvall
Takotsubo syndrome is a recently recognized acute cardiac disease entity with a clinical presentation resembling that of an acute coronary syndrome. The typical takotsubo syndrome patient has a unique circumferential left (bi-) ventricular contraction abnormality profile that extends beyond a coronary artery supply territory and appears to follow the anatomical cardiac sympathetic innervation. The syndrome predominantly affects postmenopausal women and is often preceded by emotional or physical stress. Patients with predisposing factors such as malignancy and other chronic comorbidities are more prone to suffer from takotsubo syndrome...
September 15, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28915818/the-impact-of-cardiovascular-co-morbidities-and-duration-of-diabetes-on-the-association-between-microvascular-function-and-glycaemic-control
#5
F Casanova, D D Adingupu, F Adams, K M Gooding, H C Looker, K Aizawa, F Dove, S Elyas, J J F Belch, P E Gates, R C Littleford, M Gilchrist, H M Colhoun, A C Shore, F Khan, W D Strain
BACKGROUND: Good glycaemic control in type 2 diabetes (T2DM) protects the microcirculation. Current guidelines suggest glycaemic targets be relaxed in advanced diabetes. We explored whether disease duration or pre-existing macrovascular complications attenuated the association between hyperglycaemia and microvascular function. METHODS: 743 participants with T2DM (n = 222), cardiovascular disease (CVD = 183), both (n = 177) or neither (controls = 161) from two centres in the UK, underwent standard clinical measures and endothelial dependent (ACh) and independent (SNP) microvascular function assessment using laser Doppler imaging...
September 15, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28913317/reconstruction-of-a-complex-scalp-defect-after-the-failure-of-free-flaps-changing-plans-and-strategy
#6
Youn Hwan Kim, Gyeong Hoe Kim, Sang Wha Kim
The ideal scalp reconstruction involves closure of the defect with similar hair-bearing local tissue in a single step. Various reconstructions can be used including primary closure, secondary healing, skin grafts, local flaps, and microvascular tissue transfer. A 53-year-old female patient suffered glioblastoma, which had recurred for the second time. The neurosurgeons performed radial debridement and an additional resection of the tumor, followed by reconstruction using a serratus anterior muscle flap with a split-thickness skin graft...
June 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28911306/management-of-blood-pressure-and-heart-rate-in-patients-with-diabetes-mellitus
#7
Ioanna Gouni-Berthold, Ruth Hanssen, Lisa Ravarani, Heiner K Berthold
BACKGROUND: In patients with diabetes mellitus (DM) there is a clear association between blood pressure (BP) levels and macrovascular and microvascular complications. However, the BP targets that need to be achieved for optimal outcomes remain controversial. METHODS: The purpose of this narrative review is to discuss BP targets and management in patients with DM. The subject of elevated heart rate, which has been associated with mortality in many populations, and which is observed in some patients with DM will also be addressed...
June 8, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28906481/insights-into-the-diagnostic-potential-of-extracellular-vesicles-and-their-mirna-signature-from-liquid-biopsy-as-early-biomarkers-of-diabetic-micro-macrovascular-complications
#8
REVIEW
Valeria La Marca, Alessandra Fierabracci
Extracellular vesicles (EVs) represent a heterogeneous population of small vesicles, consisting of a phospholipidic bilayer surrounding a soluble interior cargo. Almost all cell types release EVs, thus they are naturally present in all body fluids. Among the several potential applications, EVs could be used as drug delivery vehicles in disease treatment, in immune therapy because of their immunomodulatory properties and in regenerative medicine. In addition to general markers, EVs are characterized by the presence of specific biomarkers (proteins and miRNAs) that allow the identification of their cell or tissue origin...
September 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28905270/activities-of-lysosomal-enzymes-in-alloxan-induced-diabetes-in-the-mouse
#9
Bożena Witek, Danuta Rochon-Szmejchel, Iwona Stanisławska, Marek Łyp, Krzysztof Wróbel, Arkadiusz Zapała, Agnieszka Kamińska, Adam Kołątaj
The study investigated a panel of lysosomal enzymes in the liver and kidney tissues in alloxan-induced diabetes in the mouse. The mice were divided into six experimental groups receiving 10% alloxan at a dose of 50 and 75 mg/kg over a period of four, eight, and twelve days; each group was compared with controls receiving 0.9% NaCl. The findings were that diabetes induced by both doses of alloxan was accompanied by significant increases in the lysosomal activities of acid phosphatase and the glycosidases investigated: β-glucuronidase, β-galactosidase, β-glucosidase, and N-acetyl-hexosaminidase...
September 14, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28905114/long-term-outcomes-of-microvascular-decompression-and-gamma-knife-surgery-for-trigeminal-neuralgia-a-retrospective-comparison-study
#10
Takuro Inoue, Hisao Hirai, Ayako Shima, Fumio Suzuki, Masayuki Yamaji, Takanori Fukushima, Masayuki Matsuda
BACKGROUND: There is still no clear guideline for surgical treatment for patients with medically refractory trigeminal neuralgia (TN). When it comes to which surgical treatment to choose, microvascular decompression (MVD) or Gamma Knife surgery (GKS), we should know the long-term outcome of each treatment. METHODS: We analyzed 179 patients undergoing MVD and 52 patients undergoing GKS followed for 1 year or longer. We evaluated the patient's neurological status including pain relief, complications and recurrence...
September 14, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28902411/functional-changes-in-the-neural-retina-occur-in-the-absence-of-mitochondrial-dysfunction-in-a-rodent-model-of-diabetic-retinopathy
#11
Dustin R Masser, Laura Otalora, Nicholas W Clark, Michael T Kinter, Michael H Elliott, Willard M Freeman
Diabetic retinopathy is a neurovascular diabetes complication resulting in vision loss. A wealth of literature reports retinal molecular changes indicative of neural deficits, inflammation, and vascular leakage with chronic diabetes, but the mechanistic causes of disease initiation and progression are unknown. Microvascular mitochondrial DNA (mtDNA) damage leading to mitochondrial dysfunction has been proposed to drive vascular dysfunction in retinopathy. However, growing evidence suggests that neural retina dysfunction precedes and may cause vascular damage...
September 13, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28901704/audit-of-the-dietetic-care-of-patients-with-type-1-diabetes-at-a-large-australian-paediatric-tertiary-hospital-and-comparison-with-the-international-society-for-paediatric-and-adolescent-diabetes-nutrition-guidelines
#12
Rachel Battersby, Annabel Sweeney, Sarah Toome, Janice Fairchild, Jacqueline Miller
AIM: Optimal glycaemic control is important in children and adolescents with type 1 diabetes (T1D) to reduce the risk of developing microvascular complications. Modest reductions in HbA1c translate to significant risk reductions of these complications. Research indicates that targeted dietetic care using evidence-based guidelines improves HbA1c levels. The aim of this study was to audit the dietetic care provided to patients with T1D at the Women's and Children's Hospital (WCH) and compare the service provided to the International Society for Paediatric and Adolescent Diabetes (ISPAD) nutrition guidelines...
September 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28895459/hearing-loss-following-posterior-fossa-microvascular-decompression-a-systematic-review
#13
Matthew Bartindale, Matthew Kircher, William Adams, Neelam Balasubramanian, Jeffrey Liles, Jason Bell, John Leonetti
Objectives (1) Determine the prevalence of hearing loss following microvascular decompression (MVD) for trigeminal neuralgia (TN) and hemifacial spasm (HFS). (2) Demonstrate factors that affect postoperative hearing outcomes after MVD. Data Sources PubMed-NCBI, Scopus, CINAHL, and PsycINFO databases from 1981 to 2016. Review Methods Systematic review of prospective cohort studies and retrospective reviews in which any type of hearing loss was recorded after MVD for TN or HFS. Three researchers extracted data regarding operative indications, procedures performed, and diagnostic tests employed...
September 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28895276/osteoporotic-fractures-may-impair-life-as-much-as-the-complications-of-diabetes
#14
Zoltán Vokó, Katalin Gáspár, András Inotai, Csaba Horváth, Katalin Bors, Gábor Speer, Zoltán Kaló
RATIONALE, AIMS, AND OBJECTIVES: To compare the effect of osteoporotic fractures and complications of diabetes mellitus on quality of life (QoL). METHOD: A cross-sectional study was performed in 840 patients with osteoporosis and in 943 patients with diabetes in Hungary to estimate the effect of osteoporotic fractures and microvascular and macrovascular complications of diabetes on QoL using the EQ-5D questionnaire. Ordinary least-squares regression was performed for the analysis to control for age and gender...
September 12, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28894667/dual-vascular-free-anterolateral-thigh-flap
#15
Toshiaki Numajiri, Daiki Morita, Shoko Tsujiko, Hiroko Nakamura, Yoshihiro Sowa, Akihito Arai, Matsui Masahiro, Hiroshi Nakano, Shigeru Hirano
BACKGROUND: The optimum number of microvascular anastomoses for safe free tissue transfer is controversial. Although the case for 2 venous anastomoses versus 1 anastomosis has been argued, the use of an additional arterial anastomosis has not been examined in detail. METHODS: Twelve patients who underwent 2 arterial anastomoses for a free flap transfer were identified retrospectively from the medical records of patients undergoing reconstruction for head and neck cancer...
August 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28894665/late-arterial-thrombosis-after-microvascular-head-and-neck-reconstruction-due-to-combined-factors-of-pedicle-artery-loop-and-submandibular-gland-swelling
#16
Yu Kagaya, Masaki Arikawa, Shimpei Miyamoto
Late arterial thrombosis of a free flap is rare and usually unsalvageable because it is hard to detect. We herein report 2 cases of arterial thrombosis of a free flap after microvascular head and neck reconstruction due to the combined factors of pedicle artery loop and compression by a swollen submandibular gland, the occurrence of thrombosis in both of which was > 72 hours after the operation. In case 1, the arterial thrombosis was undetectable, and it was too late for a successful take-back operation, so the flap was lost...
August 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28882717/the-effects-of-combined-intraoperative-monitoring-of-abnormal-muscle-response-and-z-l-response-for-hemifacial-spasm
#17
Xin Zhang, Hua Zhao, Yin-Da Tang, Jin Zhu, Ping Zhou, Yan Yuan, Shi-Ting Li
BACKGROUND: Microvascular decompression (MVD) is the most useful treatment for hemifacial spasm (HFS). During MVD surgery, abnormal muscle response (AMR) is widely used. ZL response (ZLR) is a new monitoring method for HFS. We compared the effect of AMR plus ZLR and simple AMR. METHODS: We performed a retrospective study of 1,868 cases of HFS treated using intraoperative monitoring between January 2013 and December 2015. Among the 1,868 cases, 896 patients underwent simple AMR monitoring and 972 underwent combined intraoperative monitoring of AMR and ZLR...
September 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28878941/clinical-profiles-comorbidities-and-complications-of-type-2-diabetes-mellitus-in-patients-from-united-arab-emirates
#18
Herbert F Jelinek, Wael M Osman, Ahsan H Khandoker, Kinda Khalaf, Sungmun Lee, Wael Almahmeed, Habiba S Alsafar
OBJECTIVE: To assess clinical profiles of patients with type 2 diabetes in the United Arab Emirates (UAE), including patterns, frequencies, and risk factors of microvascular and macrovascular complications. RESEARCH DESIGN AND METHODS: Four hundred and ninety patients with type 2 diabetes were enrolled from two major hospitals in Abu Dhabi. The presence of microvascular and macrovascular complications was assessed using logistic regression, and demographic, clinical and laboratory data were collected...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28871454/non-genetic-mechanisms-of-diabetic-nephropathy
#19
REVIEW
Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu
Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetes mellitus patients and is characterized by thickened glomerular basement membrane, increased extracellular matrix formation, and podocyte loss. These phenomena lead to proteinuria and altered glomerular filtration rate, that is, the rate initially increases but progressively decreases. DN has become the leading cause of end-stage renal disease. Its prevalence shows a rapid growth trend and causes heavy social and economic burden in many countries...
September 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28865505/-prevalence-of-dental-caries-in-patients-with-type-1-diabetes-mellitus-treated-with-multiple-insulin-injections-and-that-of-individuals-without-diabetes
#20
Diogo Machado, Ana Coelho, Anabela Paula, Francisco Caramelo, Francisco Carrilho, Luísa Barros, Carla Batista, Miguel Melo, Manuel Marques Ferreira, Eunice Carrilho
INTRODUCTION: In addition to macro and microvascular complications that are associated with the disease, hyperglycaemia is also a risk factor for several oral complications. The aim of this study is to establish a relationship between dental caries in patients with type 1 diabetes mellitus treated with multiple insulin injections and that of individuals without diabetes. It is also an aim to characterize the oral hygiene habits of this population. MATERIAL AND METHODS: An observational clinical study of analytical and cross-sectional nature was conducted...
May 31, 2017: Acta Médica Portuguesa
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