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https://www.readbyqxmd.com/read/29143107/how-i-do-it-endoscopic-microvascular-decompression-for-hemifacial-spasm-associated-with-the-vertebral-artery
#1
Fuminari Komatsu, Masaaki Imai, Mitsunori Matsumae
BACKGROUND: Microvascular decompression (MVD) of hemifacial spasm (HFS) associated with the vertebral artery (VA) shows higher rates of incomplete cure and complications compared to non-VA-related HFS. METHOD: Purely endoscopic MVD for VA-associated HFS via a retrosigmoid keyhole was performed. Neurovascular conflicts by a directly offending artery and VA around the root exit zone of the facial nerve were clearly demonstrated under 30° endoscopic view without significant cerebellar retraction...
November 15, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29142635/microvascular-decompression-for-glossopharyngeal-neuralgia-clinical-analyses-of-30-cases
#2
Mi Kyung Kim, Jae Sung Park, Young Hwan Ahn
Objective: We present our experience of microvascular decompression (MVD) for glossopharyngeal neuralgia (GPN) and evaluate the postoperative outcomes in accordance with four different operative techniques during MVD. Methods: In total, 30 patients with intractable primary typical GPN who underwent MVD without rhizotomy and were followed for more than 2 years were included in the analysis. Each MVD was performed using one of four different surgical techniques: interposition of Teflon pieces, transposition of offending vessels using Teflon pieces, transposition of offending vessels using a fibrin-glue-coated Teflon sling, and removal of offending veins...
November 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29138274/five-year-effectiveness-of-the-multidisciplinary-risk-assessment-and-management-program-for-primary-care-patients-with-type-2-diabetes-mellitus%C3%A2-ramp-dm-on-dm-related-complications-and-health-service-uses-a-population-based-and-propensity-matched-cohort-study
#3
Eric Yuk Fai Wan, Colman Siu Cheung Fung, Fang Fang Jiao, Esther Yee Tak Yu, Weng Yee Chin, Daniel Yee Tak Fong, Carlos King Ho Wong, Anca Ka Chun Chan, Karina Hiu Yen Chan, Ruby Lai Ping Kwok, Cindy Lo Kuen Lam
OBJECTIVE: To evaluate the 5-year effectiveness of a multidisciplinary Risk Assessment and Management Program for primary care patients with type 2 Diabetes Mellitus (RAMP-DM)‎. RESEARCH DESIGN AND METHODS: A 5-year prospective cohort study was conducted with 121,584 Chinese primary care patients with type 2 DM who were recruited between August 2009 and June 2011. Missing data were dealt with multiple imputations. After excluding patients with prior DM-related complications and one-to-one propensity score matching on all patient characteristics, 26,718 RAMP-DM participants and 26,718 matched usual-care patients were followed up for a median time of 4...
November 14, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29137568/first-dorsal-metatarsal-artery-perforator-flap-to-cover-great-toe-defect
#4
Roongsak Limthongthang, Perajit Eamsobhana
BACKGROUND: There were very few options available for distal foot and toe defects that required a vascularized flap for coverage. As such, the use of a free flap was often justified in this region of the foot. The use of perforator flaps has created a new subset of local tissue transfer alternatives that increases the potential that the difficulties associated with microvascular tissue transfers could be avoided. The first dorsal metatarsal artery (FDMA) perforator flap was one variant of this new type of tissue transfer...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29133026/levels-of-adhesion-molecules-in-peripheral-blood-correlat-with-stages-of-diabetic-retinopathy-and-may-serve-as-bio-markers-for-microvascular-complications
#5
Arnon Blum, Nina Pastukh, Dorina Socea, Hanin Jabaly
BACKGROUND: Proliferative diabetic retinopathy is a devastating complication of diabetes mellitus, developing within 15 years in 50% of patients with type 1 diabetes mellitus (DM) and in 10% of patients with type 2 DM. The correlation between levels of inflammatory markers in the peripheral blood and retinopathy staging has not been studied yet, and the purpose of this prospective study was to find a possible association between inflammation and staging of diabetic retinopathy. METHODS: A prospective (pilot) study that measured level of adhesion molecules in the peripheral blood of 10 healthy subjects and 30 patients with type 2 diabetes mellitus...
November 10, 2017: Cytokine
https://www.readbyqxmd.com/read/29130997/non-diabetic-kidney-disease-in-type-2-diabetic-patients-prevalence-clinical-predictors-and-outcomes
#6
Siyar Erdogmus, Saba Kiremitci, Zeynep Kendi Celebi, Serkan Akturk, Neval Duman, Kenan Ates, Sehsuvar Erturk, Gokhan Nergizoglu, Sim Kutlay, Sule Sengul, Arzu Ensari, Kenan Keven
BACKGROUND/AIMS: Diabetic kidney disease (DKD) is one of the most frequent microvascular complications of diabetes and is the leading cause of end-stage kidney disease worldwide. In patients with diabetes, non-diabetic kidney disease (NDKD) can also occur. NDKD can be either alone or superimposed with the DKD. In this study, we aimed to investigate the utility of kidney biopsy in patients with type 2 diabetes mellitus (T2DM) and the predictability of diagnosing DKD versus NDKD from clinical and laboratory data...
November 1, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29129773/gambogic-acid-ameliorates-diabetes-induced-proliferative-retinopathy-through-inhibition-of-the-hif-1%C3%AE-vegf-expression-via-targeting-pi3k-akt-pathway
#7
Jianyi Cui, Rui Gong, Shuiqing Hu, Ling Cai, Lei Chen
AIMS: Gambogic acid (GA) is one of active components of Chinese medicine gamboges resin. Diabetic retinopathy (DR) is a most serious microvascular complication of diabetes and also the leading cause of blindness. The aim of this study is to evaluate the beneficial effect of GA on diabetes-induced retinal angiogenesis and further explore the potential mechanisms. MATERIAL AND METHODS: High glucose (HG)-treated RF/6A cells and STZ-induced diabetic mice were used as in vitro and in vivo models...
November 9, 2017: Life Sciences
https://www.readbyqxmd.com/read/29127507/influence-of-coupler-size-on-revision-rate-and-timing-of-revision-after-free-flap-tissue-transfer-in-the-head-and-neck
#8
Ulrich Kisser, Christine Adderson-Kisser, Philipp Baumeister, Maximilian Reiter
OBJECTIVE: Microvascular coupler devices have been proven an effective alternative to standard hand-sutured anastomoses in reconstructive surgery. Until now, the influence of the coupler size on the revision rate after free flap tissue transfer in head and neck surgery has not been investigated. Neither has its influence on the timing of venous revisions. MATERIALS AND METHODS: A retrospective mono-center cohort study was performed in order to analyze the influence of coupler size on timing and revision rate of microvascular procedures...
November 10, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29126769/cardiovascular-complications-in-head-neck-microvascular-flap-reconstruction-a-retrospective-risk-stratification-and-outcomes-assessment
#9
Naseem Ghazali, Steven Caldroney, Donita Dyalram, Joshua E Lubek
BACKGROUND: To determine the incidence and predictors of cardiac complications (CC) in head & neck microvascular flap reconstruction. METHODS: A series of 216 microvascular flaps performed between 2012 and 2015 were analyzed using the Revised Cardiac Risk Index (CRCI) and the Charlson Comorbidity Index (CCI). Multivariate regression analysis was undertaken for predictive factors of outcomes. RESULTS: Twenty patients developed CC (9.7%) with transient cardiac arrhythmia (6...
October 12, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29126250/diabetic-microvascular-disease-an-endocrine-society-scientific-statement
#10
Eugene J Barrett, Zhenqi Liu, Mogher Khamaisi, George L King, Ronald Klein, Barbara E K Klein, Timothy M Hughes, Suzanne Craft, Barry I Freedman, Donald W Bowden, Aaron I Vinik, Carolina M Casellini
Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs. Our understanding of the genesis of this injury and of potential interventions to prevent, limit, or reverse injury/dysfunction is continuously evolving. This statement reviews biochemical/cellular pathways involved in facilitating and abrogating microvascular injury. The statement summarizes the types of injury/dysfunction that occur in the three classical diabetes microvascular target tissues, the eye, the kidney, and the peripheral nervous system; the statement also reviews information on the effects of diabetes and insulin resistance on the microvasculature of skin, brain, adipose tissue, and cardiac and skeletal muscle...
November 8, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29122486/trapezius-flaps-for-reconstruction-of-head-and-neck-defects-following-oncological-resection-a-systematic-review
#11
Conor M Sugrue, Grainne Rooney, Ryan M Sugrue
OBJECTIVE: Head and neck (H&N) reconstruction after cancer resection is challenging. Myocutaneous trapezius flaps provide an alternative reconstruction for patients not suitable for microvascular free tissue transfer. METHODS: A systematic review was performed on studies involving trapezius flaps for H&N reconstruction post oncological resection between the years 1985-2015. Data extracted included patient numbers and demographics, operative technique and complications...
October 10, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29121455/bench-to-bedside-and-back-again-finding-the-goldilocks-zone-within-the-scleroderma-universe
#12
EDITORIAL
Janet E Pope, Jason J Lee, Christopher P Denton
Systemic sclerosis (SSc) is a complex inflammatory connective tissue disease characterized by skin thickening, organ fibrosis and vasculopathy [1, 2]. The underlying disease mechanisms and pathophysiology are not fully understood. However, it appears to be, at least in part, driven by autoimmunity and inflammation associated with microvascular dysfunction ultimately resulting in excess extracellular matrix deposition in target organs [2-4]. Clinical heterogeneity coupled with our lack of understanding of the disease pathogenesis means that current treatment strategies are mostly organ based therapies using anti-rheumatic drugs that were originally approved for other indications [5]...
November 9, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29121074/proteome-profiling-in-the-aorta-and-kidney-of-type-1-diabetic-rats
#13
Moustafa Al Hariri, Mohamad Elmedawar, Rui Zhu, Miran A Jaffa, Jingfu Zhao, Parvin Mirzaei, Adnan Ahmed, Firas Kobeissy, Fuad N Ziyadeh, Yehia Mechref, Ayad A Jaffa
Diabetes is associated with a number of metabolic and cardiovascular risk factors that contribute to a high rate of microvascular and macrovascular complications. The risk factors and mechanisms that contribute to the development of micro- and macrovascular disease in diabetes are not fully explained. In this study, we employed mass spectrometric analysis using tandem LC-MS/MS to generate a proteomic profile of protein abundance and post-translational modifications (PTM) in the aorta and kidney of diabetic rats...
2017: PloS One
https://www.readbyqxmd.com/read/29119919/polyphenols-and-microvascular-function-in-humans-a-systematic-review
#14
Kirsty A Woodward, Richard Draijer, Dick H J Thijssen, David A Low
BACKGROUND: Polyphenol-rich dietary sources are acknowledged to have potential cardiovascular health benefits, particularly in reducing cardiovascular disease risk. METHODS: This systematic review sought to determine the effect of polyphenol-rich foods and beverages upon microvascular function, which is of considerable importance in its contribution towards the pathophysiology of microvascular-related complications but also in the future development of (macro-vessel) cardiovascular disease...
November 8, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29118913/protease-activated-receptor-2-in-diabetic-nephropathy-a-double-edged-sword
#15
Maaike Waasdorp, JanWillem Duitman, Sandrine Florquin, Arnold C Spek
Diabetic nephropathy is a major microvascular complication of diabetes mellitus, and the leading cause of end stage renal disease worldwide. The pathogenesis of diabetic nephropathy is complex, making the development of novel treatments that stop or reverse the progression of microalbuminuria into end stage renal disease a challenge. Protease activated receptor (PAR)-2 has recently been shown to aggravate disease progression in diabetic nephropathy based upon which it was suggested that PAR-2 would be a potential target for the treatment of diabetic nephropathy...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29117833/management-of-the-pediatric-patient-following-upper-extremity-replantation-or-revascularization-a-suggested-protocol
#16
Alec Sundet, Kyros Ipaktchi, Claudia Kunrath, Rodrigo N Banegas
BACKGROUND: Traumatic pediatric amputations of the hand and upper extremity can have long-term financial, psychological, developmental, and functional consequences that readily extend beyond the realm of that which is normally encountered in comparatively injured adults. These factors, along with a paucity of medical comorbidities, have guided a more liberal and aggressive approach to treating pediatric amputations in hopes of optimizing psychosocial, aesthetic, and developmental outcomes...
December 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29113999/index-of-microcirculatory-resistance-at-the-time-of-primary-percutaneous-coronary-intervention-predicts-early-cardiac-complications-insights-from-the-oxami-oxford-study-in-acute-myocardial-infarction-cohort
#17
Gregor Fahrni, Mathias Wolfrum, Giovanni Luigi De Maria, Florim Cuculi, Sam Dawkins, Mohammad Alkhalil, Niket Patel, John C Forfar, Bernard D Prendergast, Robin P Choudhury, Keith M Channon, Adrian P Banning, Rajesh K Kharbanda
BACKGROUND: Early risk stratification after primary percutaneous coronary intervention (PPCI) for ST-segment-elevation myocardial infarction is currently challenging. Identification of a low-risk group may improve triage of patients to alternative clinical pathways and support early hospital discharge. Our aim was to assess whether the index of microcirculatory resistance (IMR) at the time of PPCI can identify patients at low risk of early major cardiac complications and to compare its performance against guideline-recommended risk scores...
November 7, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29113918/the-impact-of-diabetes-on-corneal-nerve-morphology-and-ocular-surface-integrity
#18
REVIEW
Maria Markoulli, Judith Flanagan, Shyam Sunder Tummanapalli, Jenny Wu, Mark Willcox
Diabetes mellitus is a chronic disease that results from inadequate insulin production or ineffective insulin utilization. It is one of the most common systemic diseases worldwide with increasing prevalence. Diabetes mellitus is associated with premature mortality, macrovascular complications such as cardiovascular disease, and microvascular complications, including nephropathy leading to kidney failure, potentially blinding diabetic retinopathy, and diabetic neuropathy. While the retinal complications of diabetes are well recognized by eye care professionals, the effects on the ocular surface are poorly understood...
November 4, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29110188/percutaneous-balloon-compression-for-persistent-or-recurrent-trigeminal-neuralgia-after-microvascular-decompression-personal-experience-of-28-patients
#19
Wu Xu, Chengrong Jiang, Chen Yu, Weibang Liang
The objective of this study is to investigate the long-term effects of percutaneous balloon compression (PBC) for treating persistent or recurrent trigeminal neuralgia (TN) after microvascular decompression (MVD). The clinical features, surgical findings, outcomes, and complications of 28 patients underwent PBC for TN in Nanjing Drum Tower Hospital between April 2011 and March 2015 were analyzed retrospectively. All the patients had received MVD before but they did not get cured or the symptom relapsed during follow-up...
November 6, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29107454/prevalence-of-micro-and-macrovascular-diabetes-complications-at-time-of-type-2-diabetes-diagnosis-and-associated-clinical-characteristics-a-cross-sectional-baseline-study-of-6958-patients-in-the-danish-dd2-cohort
#20
Anne Gedebjerg, Thomas Peter Almdal, Klara Berencsi, Jørgen Rungby, Jens Steen Nielsen, Daniel R Witte, Søren Friborg, Ivan Brandslund, Allan Vaag, Henning Beck-Nielsen, Henrik Toft Sørensen, Reimar Wernich Thomsen
AIMS: To examine the prevalence of micro- and macrovascular complications and their associated clinical characteristics at time of type 2 diabetes (T2D) diagnosis. METHODS: We examined the prevalence of complications and associated clinical characteristics among 6958 newly diagnosed T2D patients enrolled in the prospective Danish Center for Strategic Research in T2D cohort during 2010-2016. We calculated age- and gender-adjusted prevalence ratios (aPRs) of complications using log-binomial and Poisson regression...
September 19, 2017: Journal of Diabetes and its Complications
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