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Fragility fractures

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https://www.readbyqxmd.com/read/28089982/fragility-fractures-are-associated-with-an-increased-risk-for-cardiovascular-events-in-women-and-men-with-rheumatoid-arthritis-a-population-based-study
#1
Orla Ni Mhuircheartaigh, Cynthia S Crowson, Sherine E Gabriel, Veronique L Roger, L Joseph Melton, Shreyasee Amin
OBJECTIVE: Women and men with rheumatoid arthritis (RA) have an increased risk for fragility fractures and cardiovascular disease (CVD), each of which has been reported to contribute to excess morbidity and mortality in these patients. Fragility fractures share similar risk factors for CVD but may occur at relatively younger ages in patients with RA. We aimed to determine whether a fragility fracture predicts the development of CVD in women and men with RA. METHODS: We studied a population-based cohort with incident RA from 1955 to 2007 and compared it with age- and sex-matched non-RA subjects...
January 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28089404/the-schhs-hip-fracture-clinical-network-experience-improving-care-and-outcomes-through-an-interprofessional-approach
#2
Gillian Puckeridge, Morné Terblanche, Debbie Massey
BACKGROUND: Hip fractures are a major global health care issue, with the 1.26 million estimated cases in 1990 predicted to increase to 4.5 million by 2050. Varying models of care have been developed to improve outcomes following fragility hip fractures. Most of these care models embrace an interprofessional approach to care. Specialist orthopedic nurses play an important role in the management of fragility hip fracture patients and their contribution to the interprofessional health care team is an important predictor of patient outcomes...
December 18, 2016: International Journal of Orthopaedic and Trauma Nursing
https://www.readbyqxmd.com/read/28078372/fragility-fractures-of-the-spine
#3
EDITORIAL
Oliver Gonschorek, Marius Keel
No abstract text is available yet for this article.
January 11, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28077497/bone-material-strength-index-as-measured-by-impact-microindentation-is-altered-in-patients-with-acromegaly
#4
Frank Malgo, Neveen Hamdy, Ton J Rabelink, H Kroon, Kim M J A Claessen, Alberto M Pereira, N R Biermasz, Natasha M Appelman-Dijkstra
OBJECTIVE: Acromegaly is a rare disease caused by excess growth hormone (GH) production by a pituitary adenoma. The skeletal complications of GH and IGF-1 excess include increased bone turnover, increased cortical bone mass and deteriorated microarchitecture of trabecular bone, associated with a high risk of vertebral fractures in the presence of relatively normal Bone Mineral Density (BMD). We aimed to evaluate tissue-level properties of bone using impact microindentation (IMI) in well-controlled patients with acromegaly aged ≥18 years compared to 44 controls from the outpatient clinic of the Centre for Bone Quality...
January 11, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28070676/-upper-extremity-fractures-in-the-elderly
#5
Roland Biber, S Grüninger, H J Bail
Upper extremity fractures in the elderly are very frequent and second only to hip fractures in the group of fragility fractures. Their impact on mobility and functional decline seems to be underestimated especially when they occur in combination with lower extremity fractures. Fractures of the proximal humerus and the distal radius can often be treated conservatively; however, the indications for operative treatment must not be based on fracture morphology alone and due consideration should be given to all concomitant circumstances affecting functional aspects of patients...
January 9, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28068558/targeted-next-generation-sequencing-of-the-entire-vitamin-d-receptor-gene-reveals-polymorphisms-correlated-with-vitamin-d-deficiency-among-older-filipino-women-with-and-without-fragility-fracture
#6
Mark Pretzel Zumaraga, Paul Julius Medina, Juan Miguel Recto, Lauro Abrahan, Edelyn Azurin, Celeste C Tanchoco, Cecilia A Jimeno, Cynthia Palmes-Saloma
This study aimed to discover genetic variants in the entire 101 kB vitamin D receptor (VDR) gene for vitamin D deficiency in a group of postmenopausal Filipino women using targeted next generation sequencing (TNGS) approach in a case-control study design. A total of 50 women with and without osteoporotic fracture seen at the Philippine Orthopedic Center were included. Blood samples were collected for determination of serum vitamin D, calcium, phosphorus, glucose, blood urea nitrogen, creatinine, aspartate aminotransferase, alanine aminotransferase and as primary source for targeted VDR gene sequencing using the Ion Torrent Personal Genome Machine...
December 21, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28068425/predictive-factors-for-pressure-ulcers-in-an-older-adult-population-hospitalized-for-hip-fractures-a-prognostic-cohort-study
#7
Paolo Chiari, Cristiana Forni, Monica Guberti, Domenica Gazineo, Sabrina Ronzoni, Fabio D'Alessandro
BACKGROUND: Older adult patients with fragility hip fractures constitute a population at high risk for complications, in particular pressure ulcers. The aim was to evaluate the incidence of pressure ulcers and potential predictive factors. METHODS AND FINDINGS: A prospective multicentric prognostic cohort study in orthopedic wards in three Italian public hospitals. Participants were all consecutive patients 65 years of age or older diagnosed with a fragility hip fracture...
2017: PloS One
https://www.readbyqxmd.com/read/28065423/investigating-the-effects-of-motion-streaks-on-pqct-derived-leg-muscle-density-and-its-association-with-fractures
#8
Adrian C H Chan, Jonathan D Adachi, Alexandra Papaioannou, Andy Kin On Wong
Lower peripheral quantitative computed tomography (pQCT)-derived leg muscle density has been associated with fragility fractures in postmenopausal women. Limb movement during image acquisition may result in motion streaks in muscle that could dilute this relationship. This cross-sectional study examined a subset of women from the Canadian Multicentre Osteoporosis Study. pQCT leg scans were qualitatively graded (1-5) for motion severity. Muscle and motion streak were segmented using semi-automated (watershed) and fully automated (threshold-based) methods, computing area, and density...
January 3, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28059033/independent-relationship-of-osteocalcin-circulating-levels-with-obesity-type-2-diabetes-hypertension-and-hdl-cholesterol
#9
Giovanni De Pergola, Vincenzo Triggiani, Nicola Bartolomeo, Adele Nardecchia, Vito Angelo Giagulli, Irene Bruno, Domenico Caccavo, Franco Silvestris
BACKGROUND: Osteocalcin, a protein synthesized by osteoblasts during the bone formation phase of bone remodeling, is used as a biomarker for the bone production process, and its serum levels are positively correlated with bone mineral density during treatment with anabolic bone drugs for osteoporosis. Higher fat mass has been shown to be a risk factor for osteoporosis and fragility fractures and body fat and bone interplay through several adipokines and bone-derived molecules, regulating bone remodeling, adipogenesis, body weight control, and glucose homeostasis...
January 6, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28057908/clinical-application-of-quantitative-computed-tomography-in-osteogenesis-imperfecta-suspected-cat
#10
Sungjun Won, Woo-Jo Chung, Junghee Yoon
One year-old male Persian cat was presented with multiple fractures without known traumatic history. Marked decrease of bone radiopacity and thin cortices of all long bones were identified in radiography. Tentative diagnosis was osteogenesis imperfecta, which is congenital disorder characterized with fragile bone. To identify bone material density (BMD), quantitative computed tomography (QCT) was performed. With QCT, mean trabecular BMD of vertebral bodies was 149.9 ± 86.5 mg/cm³. After bisphosphonate therapy, BMD of same site was 218...
January 4, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28043896/marrow-adipose-tissue-composition-in-adults-with-morbid-obesity
#11
Elaine W Yu, Logan Greenblatt, Alireza Eajazi, Martin Torriani, Miriam A Bredella
Patients with type 2 diabetes mellitus (T2DM) have increased fracture risk despite normal or increased bone mineral density (BMD). Elevations in marrow adipose tissue (MAT) and declines in MAT unsaturation are both associated with increased skeletal fragility. The objective of our study was to characterize the quantity and composition of MAT in adults with morbid obesity and T2DM, and to evaluate determinants of MAT. We studied 21 adults with morbid obesity prior to bariatric surgery, 8 of whom had T2DM. All subjects underwent 1H-MR spectroscopy of the lumbar spine and femur for assessment of MAT and dual-energy x-ray absorptiometry (DXA) and quantitative computed tomography (QCT) of the lumbar spine and hip for assessment of areal BMD (aBMD) and volumetric BMD (vBMD)...
December 30, 2016: Bone
https://www.readbyqxmd.com/read/28042512/the-measurement-of-bone-quality-using-gray-level-co-occurrence-matrix-textural-features
#12
Mukul Shirvaikar, Ning Huang, Xuanliang Neil Dong
In this paper, statistical methods for the estimation of bone quality to predict the risk of fracture are reported. Bone mineral density and bone architecture properties are the main contributors of bone quality. Dual-energy X-ray Absorptiometry (DXA) is the traditional clinical measurement technique for bone mineral density, but does not include architectural information to enhance the prediction of bone fragility. Other modalities are not practical due to cost and access considerations. This study investigates statistical parameters based on the Gray Level Co-occurrence Matrix (GLCM) extracted from two-dimensional projection images and explores links with architectural properties and bone mechanics...
October 2016: Journal of Medical Imaging and Health Informatics
https://www.readbyqxmd.com/read/28039870/outcomes-of-treated-hypertension-at-age-80-and-older-cohort-analysis-of-79-376-individuals
#13
João Delgado, Jane A H Masoli, Kirsty Bowman, W David Strain, George A Kuchel, Kate Walters, Louise Lafortune, Carol Brayne, David Melzer, Alessandro Ble
OBJECTIVES: To estimate outcomes according to attained blood pressure (BP) in the oldest adults treated for hypertension in routine family practice. DESIGN: Cohort analysis of primary care inpatient and death certificate data for individuals with hypertension. SETTING: Primary care practices in England (Clinical Practice Research Datalink). PARTICIPANTS: Individuals aged 80 and older taking antihypertensive medication and free of dementia, cancer, coronary heart disease, stroke, heart failure, and end-stage renal failure at baseline...
December 30, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28034360/role-of-nanoparticles-in-drug-delivery-and-regenerative-therapy-for-bone-diseases
#14
Sonia Gera, Sunitha Sampathi, Sujatha Dodoala
Osteoporosis (OP) is a disease characterized by progressive bone loss due to aging and menopause in women leading to bone fragility with increased susceptibility towards fractures. The silent disease weakens the bone by altering its microstructure and mass. Therapy is based on either promoting strength (via osteoblast action) or preventing disease (via osteoclast action). Current therapy with different drugs belonging to antiresorptive, anabolic and hormonal classification suffers from poor pharmacokinetic and pharmacodynamic profile...
December 30, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/28032704/treatment-and-management-of-osteoporotic-fractures-a-nation-wide-survey-of-484-senior-orthopaedists-in-china
#15
Yi Man, Wei Pan, Jin Lu, Sen-Yuan Li, Pian Zhang, Jun-Zhe Guo, Shu-Fang Yu, Bei Zhang, En Xiao, Chao Zhang, Wei Zuo, He-Juan Jin, Yi Chen, Bin Wu, Xiao-En Shi, Di Hong, Xun Liu, Ying-Xu Gao, Jing Li, Lu Yin, Qing-Yun Xue
OBJECTIVE: To investigate the treatment given to osteoporotic fracture patients by orthopaedists at major hospitals in China. METHODS: A 25-item quantitative questionnaire survey, categorized into five domains, including primary purpose of osteoporosis treatment, anti-osteoporosis therapy, calcium and vitamin D supplement, monitoring of osteoporosis, and knowledge of osteoporosis treatment, was designed to elicit information on orthopaedists' views on the treatment of osteoporotic fracture...
November 2016: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28028555/hip-and-other-fragility-fracture-incidence-in-real-world-teriparatide-treated-patients-in-the-united-states
#16
R T Burge, D P Disch, S Gelwicks, X Zhang, J H Krege
: This study demonstrates real-world effectiveness of teriparatide in reducing the risk of hip and other fragility fractures. Fracture incidence significantly decreased as adherence and persistence increased for any clinical, vertebral, nonvertebral, and hip fractures among patients who were observed for 2 years after teriparatide initiation. INTRODUCTION: Examine the relationship of treatment adherence and persistence to teriparatide with hip and other fractures...
December 27, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/28025971/-primary-and-secondary-prevention-of-hip-fragility-fracture-in-teruel-health-sector-aragon-spain
#17
Rafael Gómez Navarro, Paloma González García, Carlos Martín Hernández, Ángel Castro Sauras, Santiago Valdearcos Enguídanos
OBJECTIVE: Osteoporosis should be prevented, diagnosed and treated, preferably before the fragility fracture occurs. The objective was to analyze primary and secondary interventions carried out in individuals diagnosed with femur fragility fracture at Teruel in 2014. METHODS: Descriptive retrospective study. Variables assessed were sex, age, main health district, place of residence, basal functional situation, diagnosis on osteoporosis, hip or vertebral fracture, loss of height, use of FRAX tool, treatment on discharge, survival and cause of exitus...
January 2, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/28017957/-development-of-osteoporosis-drugs-the-past-the-present-and-the-future
#18
Shinya Tanaka
From 1990s to 2000s, new drugs for osteoporosis have been developed, and the bone metabolism researches have livened up. In those days, many a people gathered to the meeting from many countries, and the each booth of pharmaceutics was proud of its preeminence. The dedications by the society and its members have had osteoporosis diagnostics developed, the anchor drugs become prevalent, and the number of fractures reduced. Although the brilliant effects of Romosozumab and Abaloparatide were presented in the meeting held this year, the members had to accept the convergence state of new drug developments...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28012057/chronic-kidney-disease-and-fragility-fracture
#19
REVIEW
Junichiro James Kazama
Osteoporosis is defined simply as "a skeletal disorder characterized by compromised bone strength predisposing to an increased risk of fracture. Thus, any bone lesion that causes fragility fracture is osteoporosis, which has quite heterogeneous backgrounds. Chronic kidney disease-related bone and mineral disease (CKD-MBD) is defined as "a systemic disorder of mineral and bone metabolism due to CKD, which is manifested by abnormalities in bone and mineral metabolism and/or extra-skeletal calcification". Although CKD-MBD is one of the possible causes of osteoporosis, we do not have evidences that CKD-MBD is the only or crucial determinant of bone mechanical strength in CKD patients...
December 23, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28009707/the-spine-in-patients-with-osteogenesis-imperfecta
#20
Maegen J Wallace, Richard W Kruse, Suken A Shah
Osteogenesis imperfecta is a genetic disorder of type I collagen. Although multiple genotypes and phenotypes are associated with osteogenesis imperfecta, approximately 90% of the mutations are in the COL1A1 and COL1A2 genes. Osteogenesis imperfecta is characterized by bone fragility. Patients typically have multiple fractures or limb deformity; however, the spine can also be affected. Spinal manifestations include scoliosis, kyphosis, craniocervical junction abnormalities, and lumbosacral pathology. The incidence of lumbosacral spondylolysis and spondylolisthesis is higher in patients with osteogenesis imperfecta than in the general population...
December 22, 2016: Journal of the American Academy of Orthopaedic Surgeons
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