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group b streptococcus screening pregnancy

Kathryn A Patras, Kelly S Doran
Streptococcus agalactiae (group B Streptococcus, GBS), is a Gram-positive, asymptomatic colonizer of the human gastrointestinal tract and vaginal tract of 10 - 30% of adults. In immune-compromised individuals, including neonates, pregnant women, and the elderly, GBS may switch to an invasive pathogen causing sepsis, arthritis, pneumonia, and meningitis. Because GBS is a leading bacterial pathogen of neonates, current prophylaxis is comprised of late gestation screening for GBS vaginal colonization and subsequent peripartum antibiotic treatment of GBS-positive mothers...
November 16, 2016: Journal of Visualized Experiments: JoVE
H Sefty, A Klivitsky, M Bromberg, R Dichtiar, M Ben Ami, T Shohat, A Glatman-Freedman
BACKGROUND: The crude rate of early-onset Group B streptococcus disease (EOGBS) in Israel has been consistently under 0.5 for 1000 live births for the past 8 years. The Israeli Ministry of Health has adapted the risk factor based approach for preventing EOGBS and universal bacteriological screening for GBS is not recommended. In spite of this policy, there are indications that many pregnant women in Israel undergo bacteriological screening for GBS. The objective of this study is to assess the rate and characteristics of pregnant women who undergo screening for group B streptococcus (GBS) colonization in Israel...
2016: Israel Journal of Health Policy Research
Yi-Ping Li, Chi-Man Kuok, Shin-Yu Lin, Wu-Shiun Hsieh, Ming-Kwang Shyu
AIM: In this study, we collected group B streptococcus (GBS) screening data and analyzed screening rate, antimicrobial resistance rate, and neonatal observation room (NOR) admission rate due to inadequate chemoprophylaxis. METHODS: The GBS screening data for January 2006-December 2013 were retrospectively collected and analyzed. We also collected data for neonates admitted to NOR due to inadequate chemoprophylaxis during the period 1 April 2010-31 December 2013...
November 2016: Journal of Obstetrics and Gynaecology Research
J Raignoux, M Benard, S Huo Yung Kai, O Dicky, A Berrebi, L Bibet, A-S Chetouani, N Marty, L Cavalie, C Casper, C Assouline-Azogui
INTRODUCTION: Group B streptococcus (GBS) is the most common infectious agent responsible for early-onset bacterial sepsis (EOS) in term newborns. French prevention of perinatal GBS disease guidelines recommend screening for maternal vaginal GBS colonization at the 9th month of pregnancy, and use of intrapartum antibiotic prophylaxis (IAP) in case of detected GBS vaginal colonization. Peripheral bacterial sampling (gastric aspiration, ear, or meconium) and measurement of C-reactive protein (CRP) are performed in asymptomatic newborns in case of infectious risk factors and/or incomplete IAP...
September 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
M Defez, F Khizar, M Maurin, F Biot, J-C Pons, F Sergent
OBJECTIVES: The objectives were to evaluate and compare the diagnostic accuracy of a rapid real-time PCR assay at the onset of labor with those of the current antenatal culture-based test at 34-38 weeks gestation for group B Streptococcus (GBS) screening. MATERIALS AND METHODS: A prospective study including all pregnant women admitted for delivery after a 34-week gestation period was conducted in October 2012 at the Grenoble University Hospital Centre. A first culture-based GBS screening test was performed between 34 and 38 weeks of gestation followed by a second screening test at the onset of labor, using a real-time PCR Assay and a culture-based method (gold standard) in order to calculate the diagnostic accuracy...
November 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
Assaad Kesrouani, Elie Chalhoub, Elie El Rassy, Mirna Germanos, Aline Khazzaka, Jamale Rizkallah, Elie Attieh, Norma Aouad
OBJECTIVE: To search for a correlation between mid-pregnancy altered levels of inflammatory markers and preterm delivery. METHODS: A prospective cohort series included 39 patients undergoing amniocentesis one additional milliliter of amniotic fluid (AF) was stored for later dosage of interleukin-6 (Il-6), matrix metalloproteinase-9 (MMP-9), glucose and C-reactive protein (CRP). Maternal serum CRP and glucose levels were also obtained. Exclusion criteria were multiple pregnancies, chorioamnionitis, group B streptococcus colonization, bacterial vaginosis and cases with proven aneuploidy...
September 2016: Cytokine
Shabir A Madhi, Clare L Cutland, Lisa Jose, Anthonet Koen, Niresha Govender, Frederick Wittke, Morounfolu Olugbosi, Ajoke Sobanjo-Ter Meulen, Sherryl Baker, Peter M Dull, Vas Narasimhan, Karen Slobod
BACKGROUND: Maternal group B streptococcus (GBS) serotype-specific capsular antibody concentrations are correlated with susceptibility to neonatal GBS invasive disease. Maternal immunisation against GBS during pregnancy might protect infants across the period of susceptibility to invasive disease, but no licensed vaccine exists. This study assessed the safety and immunogenicity of a CRM197-conjugated trivalent GBS vaccine in non-pregnant and pregnant women, and antibody transfer to their infants...
August 2016: Lancet Infectious Diseases
X Wang, L K Ma, Y N Song, J T Liu, Y C Xu, J Yi
OBJECTIVE: To study the sensitivity of the quantitative fluorescence polymerase chain reaction (QF-PCR) in detecting group B streptococcus (GBS) in late pregnant women and the influence of vaginal/rectal GBS colonization on the maternal-neonatal outcomes. METHODS: A total of 2020 swabs were taken from 505 women who received routine culture and QF-PCR screening at 35 and 37 weeks of gestation from September, 2013 to April, 2014 at Peking Union Medical College Hospital...
April 19, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Piet Cools, Vicky Jespers, Liselotte Hardy, Tania Crucitti, Sinead Delany-Moretlwe, Mary Mwaura, Gilles F Ndayisaba, Janneke H H M van de Wijgert, Mario Vaneechoutte
BACKGROUND: One million neonates die each year in low- and middle-income countries because of neonatal sepsis; group B Streptococcus (GBS) and Escherichia coli are the leading causes. In sub-Saharan Africa, epidemiological data on vaginal GBS and E. coli carriage, a prerequisite for GBS and E. coli neonatal sepsis, respectively, are scarce but necessary to design and implement prevention strategies. Therefore, we assessed vaginal GBS and E. coli carriage rates and risk factors and the GBS serotype distribution in three sub-Saharan countries...
2016: PloS One
Mark A Turrentine, Laura C Colicchia, Emmet Hirsch, Po-Jen Cheng, Teresa Tam, Patrick S Ramsey, Sarah M Page-Ramsey
OBJECTIVE: The objective of this study was to evaluate the risk of recurrent group B streptococcus (GBS) colonization in a subsequent pregnancy and to assess clinical characteristics that influence this risk. STUDY DESIGN: A systematic review and meta-analysis was performed. Databases were searched from inception through June 2015 using PubMed, Embase, Scopus, Central, and Studies were eligible if they assessed antenatal GBS colonization in two successive pregnancies...
April 2016: American Journal of Perinatology
Kristen M Basnet, Rhonda Bentley-Lewis, Deborah J Wexler, Fusun Kilic, Drucilla J Roberts
Intervillous thrombus (IVT) is a placental pathology of unclear cause. One possible cause is that IVT protects against fetomaternal transfusion due to trophoblastic disruption. A role for hyperglycemia in trophoblast apoptosis has been suggested. We sought to determine whether placentas from pregnancies complicated by diabetes had an increased incidence of IVT. Medical records of 206 patients with type 1 diabetes (n = 39), type 2 diabetes (n = 37), and gestational diabetes (GDM, n = 130) at the Massachusetts General Hospital were identified...
November 2016: Pediatric and Developmental Pathology
Danielle Clack
Women in Australia are offered a variety of options for screening and treatment of group B streptococcus (GBS), depending on which health service they are engaged with, including a risk-based approach or universal screening. The difficulty for midwives when addressing the evidence supporting these differing policies is that there is no unified national policy on GBS screening in Australia. Furthermore, the Australian population is a discerning one, questioning the implications of procedures and exploring all options...
October 2015: Practising Midwife
S Ahmad
This study aims to determine the asymptomatic bacteriuria in pregnancy due to GBS and its antimicrobial sensitivity pattern for planning strategy for the management of these cases and also to determine the relationship between asymptomatic bacteriuria and pyuria. A total of 3863 consecutive urine specimens were collected from 3863 pregnant women with asymptomatic bacteriuria attending the obstetrics and gynaecology department of our hospital over a period of two years. Specimens were processed using standard microbiological procedures...
2015: British Journal of Biomedical Science
Agata Pruss, Katarzyna Galant, Stefania Giedrys-Kalemba
OBJECTIVE: The aim of the study was to determine the degree of colonization Streptococcus agalactiae (GBS--Group B Streptococcus) in women at 35.-37. weeks of pregnancy and to evaluate drug susceptibility of the isolated strains. MATERIAL AND METHODS: We analyzed the results of 1111 tests for GBS colonization performed between 2010-2013 in pregnant women (aged 16-40) from the West Pomeranian region. Swabs were taken from the vagina and the anus of the study subjects at 35...
August 2015: Ginekologia Polska
Jennifer Ka Yee Ko, Sofie Shuk Fei Yung, Mimi Tin Yan Seto, Chin Peng Lee
BACKGROUND: Group B Streptococcus (GBS) is a leading cause of neonatal morbidity and mortality. In an effort to reduce the impact of this serious affliction, universal screening for GBS has been adopted in many countries. The objective of this study was to examine the acceptability of self-collected GBS swabs in a local population in Hong Kong. METHODS: This study is a cross-sectional questionnaire survey conducted in a tertiary teaching hospital. A total of 327 pregnant women who attended the antenatal clinic for GBS screening from April 2012 to May 2012 were included in our study...
February 2016: Journal of the Chinese Medical Association: JCMA
Alberto Berardi, Chiara Cattelani, Roberta Creti, Reinhard Berner, Zaira Pietrangiolillo, Immaculada Margarit, Domenico Maione, Fabrizio Ferrari
Group B Streptococcus (GBS) is a leading cause of neonatal bacterial infections in developed countries. Early-onset disease (EOD) occurs at day 0-6 and late-onset disease occurs at day 7-89. Currently, the prevention of EOD relies upon intrapartum antibiotic prophylaxis (IAP) given to women who are GBS positive at prenatal screening or women with risk factors for EOD. Although successfully implemented, IAP has not fully eradicated EOD, and incidence rates of late-onset disease remain unchanged. Furthermore, antibiotic resistance may result from widespread antibiotic use...
2015: Expert Review of Anti-infective Therapy
Magdalena Bulska, Piotr Szcześniak, Anna Stepowicz, Aleksandra Wasiak, Agnieszka Pięta-Dolińska, Przemysław Oszukowski, Daria Orszulak-Michalak
OBJECTIVES: The aim of the study was to investigate the effectiveness of erythromycin in preventing intrauterine infection caused by group B streptococcus (GBS). MATERIAL AND METHODS: The study included 20 pregnant women with GBS-positive screening or whose laboratory screening was not available, who delivered between April 17, 2013 and July 22, 2013. The women were given 600 mg of erythromycin intravenously After delivery blood was drawn in parallel from maternal antecubital vein and umbilical cord artery Serum erythromycin concentrations were evaluated using enzyme-linked immunosorbent assay (ELISA) kit...
June 2015: Ginekologia Polska
Kathryn A Patras, Philip A Wescombe, Berenice Rösler, John D Hale, John R Tagg, Kelly S Doran
Streptococcus agalactiae (group B streptococcus [GBS]) colonizes the rectovaginal tract in 20% to 30% of women and during pregnancy can be transmitted to the newborn, causing severe invasive disease. Current routine screening and antibiotic prophylaxis have fallen short of complete prevention of GBS transmission, and GBS remains a leading cause of neonatal infection. We have investigated the ability of Streptococcus salivarius, a predominant member of the native human oral microbiota, to control GBS colonization...
September 2015: Infection and Immunity
Wondemagegn Mulu, Mulat Yimer, Yohannes Zenebe, Bayeh Abera
BACKGROUND: Bacterial vaginosis, candidal, trichomonal and Gonococcal vaginal infections are a major health problems associated with gynecologic complications and increase in replication, shedding and transmission of HIV and other STIs in women of reproductive age. The study aimed at determining the prevalence of common vaginal infections and antimicrobial susceptibility profiles of aerobic bacterial isolates in women of reproductive age, attending Felegehiwot referral Hospital. METHODS: A hospital based cross sectional study was conducted from May to November, 2013...
2015: BMC Women's Health
Tanja Obermajer, Luka Lipoglavšek, Gorazd Tompa, Primož Treven, Petra Mohar Lorbeg, Bojana Bogovič Matijašić, Irena Rogelj
Microbial communities inhabiting the breast milk microenvironment are essential in supporting mammary gland health in lactating women and in providing gut-colonizing bacterial 'inoculum' for their infants' gastro-intestinal development. Bacterial DNA was extracted from colostrum samples of 45 healthy Slovenian mothers. Characteristics of the communities in the samples were assessed by polymerase chain reaction (PCR) coupled with denaturing gradient gel electrophoresis (DGGE) and by quantitative real-time PCR (qPCR)...
2014: PloS One
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