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https://www.readbyqxmd.com/read/28749253/randomized-crossover-study-investigating-daily-versus-on-demand-vulvar-visnadine-spray-in-women-affected-by-female-sexual-arousal-disorder
#1
Salvatore Caruso, Diletta Mauro, Maria Cariola, Valentina Fava, Agnese Maria Chiara Rapisarda, Antonio Cianci
The aim of the study was to verify the efficacy of vulvar Visnadine spray in premenopausal women affected by female sexual arousal disorder (FSAD). Thirty-eight women aged 25-40 years affected by FSAD were enrolled in the randomized crossover study, by two possible sequences: on-demand, washout, daily (A sequence); and daily, washout, on-demand (B sequence). The Female Sexual Function Index (FSFI) and the Female Sexual Distress Scale (FSDS) were used to assess sexual function and sexual distress, respectively...
July 27, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28747643/generation-of-ribosome-imprinted-polymers-for-sensitive-detection-of-translational-responses
#2
Helen A King, Hazim F El-Sharif, Ana M Matia-González, Valentina Iadevaia, Adeola Fowotade, Subrayal M Reddy, André P Gerber
Whilst the profiling of the transcriptome and proteome even of single-cells becomes feasible, the analysis of the translatome, which refers to all messenger RNAs (mRNAs) engaged with ribosomes for protein synthesis, is still an elaborate procedure requiring millions of cells. Herein, we report the generation and use of "smart materials", namely molecularly imprinted polymers (MIPs) to facilitate the isolation of ribosomes and translated mRNAs from merely 1,000 cells. In particular, we show that a hydrogel-based ribosome imprinted polymer could recover ribosomes and associated mRNAs from human, simian and mice cellular extracts, but did not selectively enrich yeast ribosomes, thereby demonstrating selectivity...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747446/transcranial-magnetic-stimulation-distinguishes-alzheimer-disease-from-frontotemporal-dementia
#3
Alberto Benussi, Francesco Di Lorenzo, Valentina Dell'Era, Maura Cosseddu, Antonella Alberici, Salvatore Caratozzolo, Maria Sofia Cotelli, Anna Micheli, Luca Rozzini, Alessandro Depari, Alessandra Flammini, Viviana Ponzo, Alessandro Martorana, Carlo Caltagirone, Alessandro Padovani, Giacomo Koch, Barbara Borroni
OBJECTIVE: To determine whether a transcranial magnetic stimulation (TMS) multiparadigm approach can be used to distinguish Alzheimer disease (AD) from frontotemporal dementia (FTD). METHODS: Paired-pulse TMS was used to investigate short-interval intracortical inhibition (SICI) and facilitation (ICF), long-interval intracortical inhibition, and short-latency afferent inhibition (SAI) to measure the activity of different intracortical circuits in patients with AD, patients with FTD, and healthy controls (HC)...
July 26, 2017: Neurology
https://www.readbyqxmd.com/read/28747268/screening-of-depression-in-cardiology-a-study-on-617-cardiovascular-patients
#4
Valentina Tesio, Sebastiano Marra, Stefania Molinaro, Riccardo Torta, Fiorenzo Gaita, Lorys Castelli
BACKGROUND: Depression screening in the cardiovascular disease (CVD) care setting is under-performed, also because the issue of the optimal screening tools cut-off is still open. We analysed which HADS (Hospital Anxiety and Depression Scale) total score cut-off value shows the best properties in two groups of 357 Acute Coronary Syndrome (ACS) and 260 Chronic Coronary Artery Disease (CAD) hospitalized patients. METHODS: A Receiver Operating Characteristics (ROC) curve was plotted for both groups using the Montgomery-Asberg Depression Rating Scale (MADRS) as the criterion...
July 20, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28746779/hepatic-farnesoid-x-receptor-protein-level-and-circulating-fibroblast-growth-factor-19-concentration-in-children-with-nafld
#5
Valerio Nobili, Anna Alisi, Antonella Mosca, Claudia Della Corte, Silvio Veraldi, Rita De Vito, Cristiano De Stefanis, Valentina D'Oria, Joerg Jahnel, Evelyn Zohrer, Eleonora Scorletti, Christopher D Byrne
BACKGROUND & AIMS: Treatment with the farnesoid X receptor (FXR) agonist obeticholic acid is ineffective in some patients with non-alcoholic steatohepatitis (NASH) but the explanation is uncertain. We investigated hepatic FXR expression, and measurements of fibroblast growth factor 19 (FGF19) and bile acids (BAs) in children with NAFLD to investigate relationships with NASH. METHODS: 33 children with NAFLD who underwent diagnostic liver biopsy were studied. Hepatic FXR protein levels and circulating FGF19 concentrations were compared with those analyzed in five control subjects with proven normal liver histology...
July 26, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28745079/cytokine-production-in-mammary-adenocarcinoma-and-its-microenvironmental-cells-in-patients-with-or-without-metastases-in-regional-lymph-nodes
#6
Alexander Autenshlyus, Sergey Arkhipov, Elena Mikhailova, Igor Marinkin, Valentina Arkhipova, Ekaterina Mogilnaya, Nikolay Varaksin, Michael Rukavishnikov
In recent years, the concept of formation of a sufficiently autonomous cytokine network in a malignant tumour has emerged. In this regard, the data on the role of this network and its signalling pathways in the process of metastasis are an interesting topic. The aim of this study was to evaluate the in vitro cytokine-producing potential of mammary adenocarcinoma (MAC; and cells of its microenvironment) from patients with or without metastases in regional lymph nodes (LNs). By enzyme-linked immunosorbent assays of culture supernatants, we studied the cytokine production by biopsy samples of MAC: spontaneous and stimulated by polyclonal activators (PAs: phytohaemagglutinin, concanavalin A and lipopolysaccharide)...
July 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/28744867/antiepileptic-drug-discontinuation-by-people-with-epilepsy-in-the-general-population
#7
Giorgia Giussani, Elisa Bianchi, Valentina Canelli, Giuseppe Erba, Carlotta Franchi, Alessandro Nobili, Josemir W Sander, Ettore Beghi
OBJECTIVE: Rate, reasons, and predictors of antiepileptic drug (AED) discontinuation were investigated in a well-defined cohort of people with epilepsy to verify efficacy and tolerability of treatment up to 20 years from treatment initiation. METHODS: The history of AED usage in children and adults with epilepsy registered with 123 family physicians in an area of Northern Italy between 2000 and 2008 was recorded. Cumulative probabilities of AED withdrawal for specific reasons were estimated using cumulative incidence functions...
July 26, 2017: Epilepsia
https://www.readbyqxmd.com/read/28744723/-body-modifications-and-sexual-health-impact-of-tattoos-body-piercing-and-esthetic-genital-plastic-surgery-on-the-sexual-health-of-women-and-men
#8
REVIEW
Aglaja Valentina Stirn, Ronja Zannoni
The present paper addresses the psychological impact of body modifications (e.g. tattoos, body piercing and esthetic genital plastic surgery) on the sexual health of individuals and refers to past and present research insights. Body modifications are understood as invasive interventions on the human body, especially interventions on the human skin which result in (semi-)permanent changes. Tattoos and body piercing (in particular genital piercing) positively affect the sexual satisfaction and the sexual appeal of men and women but there is a controversial association with high risk sexual behavior...
July 25, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28743719/the-atypical-receptor-ccrl2-is-required-for-cxcr2-dependent-neutrophil-recruitment-and-tissue-damage
#9
Annalisa Del Prete, Laura Martínez-Muñoz, Cristina Mazzon, Lara Toffali, Francesca Sozio, Lorena Za, Daniela Bosisio, Luisa Gazzurelli, Valentina Salvi, Laura Tiberio, Chiara Liberati, Eugenio Scanziani, Annunciata Vecchi, Carlo Laudanna, Mario Mellado, Alberto Mantovani, Silvano Sozzani
CCRL2 is a seven transmembrane domain receptor that shares structural and functional similarities with the family of the Atypical Chemokine Receptors (ACKRs). CCRL2 is upregulated by inflammatory signals and, unlike from other ACKRs, is not a chemoattractant scavenging receptor, does not activate β-arrestins and is widely expressed by many leukocyte subsets. Therefore, the biological role of CCRL2 in immunity is still unclear. Here we report that CCRL2-deficient mice have a defect in neutrophil recruitment and are protected in two models of inflammatory arthritis...
July 25, 2017: Blood
https://www.readbyqxmd.com/read/28743128/anti-vascular-endothelial-growth-factors-protect-retinal-pigment-epithelium-cells-against-oxidation-by-modulating-nitric-oxide-release-and-autophagy
#10
Stefano De Cillà, Serena Farruggio, Stela Vujosevic, Giulia Raina, Davide Filippini, Valentina Gatti, Nausicaa Clemente, David Mary, Diego Vezzola, Giamberto Casini, Luca Rossetti, Elena Grossini
BACKGROUND/AIMS: the anti-vascular endothelial growth factors (VEGF), Aflibercept and Ranibizumab, are used for the treatment of macular degeneration. Here we examined the involvement of nitric oxide (NO), mitochondria function and of apoptosis/autophagy in their antioxidant effects in human retinal pigment epithelium cells (RPE). METHODS: RPE were exposed to Ranibizumab/Aflibercept in the absence or presence of NO synthase (NOS) inhibitor and of autophagy activator/blocker, rapamicyn/3-methyladenine...
July 25, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28742879/epidemiological-investigations-of-the-introduction-of-porcine-reproductive-and-respiratory-syndrome-virus-in-chile-2013-2015
#11
Víctor Neira, Barbara Brito, Juan Mena, Marie Culhane, Maria Ignacia Apel, Vanessa Max, Patricio Perez, Valentina Moreno, Christian Mathieu, Magdalena Johow, Catalina Badia, Montserrat Torremorell, Rafael Medina, Rene Ortega
Porcine reproductive and respiratory syndrome (PRRS) is endemic in most pork producing countries. In Chile, eradication of PRRS virus (PRRSV) was successfully achieved in 2009 as a result of the combined efforts of producers and the animal health authorities. In October 2013, after several years without detecting PRRSV under surveillance activities, suspected cases were confirmed on a commercial swine farm. Here, we describe the PRRS epidemic in Chile between October 2013 and April 2015, and we studied the origins and spread of PRRSV throughout the country using official surveillance data and Bayesian phylogenetic analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28742227/melatonin-prevents-mitochondrial-dysfunctions-and-death-in-differentiated-skeletal-muscle-cells
#12
Sara Salucci, Michela Battistelli, Valentina Baldassarri, Debora Burini, Elisabetta Falcieri, Sabrina Burattini
Oxidative stress increase induces cellular damage and apoptosis activation, a mechanism believed to represent a final common pathway correlated to sarcopenia and many skeletal muscle disorders. The goal of this study is to evaluate if melatonin, a ROS scavenger molecule, is able to counteract or modulate myotube death. Here, differentiated C2C12 skeletal muscle cells have been treated with melatonin before chemicals known to induce apoptotic death and oxidative stress, and its effect has been investigated by means of morpho-functional analyses...
July 25, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28742022/modeling-of-axonal-endoplasmic-reticulum-network-by-spastic-paraplegia-proteins
#13
Belgin Yalçın, Lu Zhao, Martin Stofanko, Niamh C O'Sullivan, Zi Han Kang, Annika Roost, Matthew R Thomas, Sophie Zaessinger, Olivier Blard, Alex L Patto, Anood Sohail, Valentina Baena, Mark Terasaki, Cahir J O'Kane
Axons contain a smooth tubular endoplasmic reticulum (ER) network that is thought to be continuous with ER throughout the neuron; the mechanisms that form this axonal network are unknown. Mutations affecting reticulon or REEP proteins, with intramembrane hairpin domains that model ER membranes, cause an axon degenerative disease, hereditary spastic paraplegia (HSP). We show that Drosophila axons have a dynamic axonal ER network, which these proteins help to model. Loss of HSP hairpin proteins causes ER sheet expansion, partial loss of ER from distal motor axons, and occasional discontinuities in axonal ER...
July 25, 2017: ELife
https://www.readbyqxmd.com/read/28741392/recent-advances-in-the-development-and-use-of-molecular-tests-to-predict-antimicrobial-resistance-in-neisseria-gonorrhoeae
#14
Valentina Donà, Nicola Low, Daniel Golparian, Magnus Unemo
The number of genetic tests, mostly real-time PCRs, to detect antimicrobial resistance (AMR) determinants and predict AMR in Neisseria gonorrhoeae is increasing. Several of these assays are promising, but there are important shortcomings and few assays have been adequately validated and quality assured. Areas covered: Recent advances, focusing on publications since 2012, in the development and use of molecular tests to predict gonococcal AMR for surveillance and for clinical use, advantages and disadvantages of these tests and of molecular AMR prediction compared with phenotypic AMR testing, and future perspectives for effective use of molecular AMR tests for different purposes...
July 25, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28741085/the-effect-of-sleep-deprivation-on-retrieval-of-emotional-memory-a-behavioural-study-using-film-stimuli
#15
Daniela Tempesta, Valentina Socci, Giada Dello Ioio, Luigi De Gennaro, Michele Ferrara
Although the deleterious effects of sleep deprivation on memory consolidation are well documented, it is still unclear how the facilitating effect of emotions on memory consolidation processes could be modulated by the lack of sleep. In this study, we investigated the effects of sleep deprivation on episodic memory using emotional and non-emotional film stimuli. Forty-eight healthy subjects, divided into a sleep group (SG) and a sleep-deprived (SD) group, completed an Encoding and a Recall phase. Participants in the SD group were sleep deprived the night immediately following the Encoding phase, whereas the control group slept at home...
July 24, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28740532/is-this-a-seizure
#16
Giulio Franceschet, Marta Mazzucato, Simona Censi, Stefano Simmini, Marco Boscaro, Valentina Camozzi
We describe a case of a 65-year-old woman admitted to the hospital for suspected of epileptic crisis. She was affected by diabetes and hiatal hernia for which she was taking Proton Pump Inhibitors (PPIs) for about 8 years. She showed hypocalcaemia, hypomagnesaemia, hyperparathyroidism and severe hypovitaminosis D. We exclude malabsorption and magnesium loss. After restored vitamin D levels, stopped use of PPI, start calcium and magnesium supplementation normal values of the ions were restored. This case underlies the importance of evaluate magnesium routinely, other than calcium and vitamin D, and use PPI more carefully...
January 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28740429/comparative-diagnostic-accuracy-of-18f-fdg-pet-ct-for-breast-cancer-recurrence
#17
REVIEW
Roberta Piva, Flavia Ticconi, Valentina Ceriani, Federica Scalorbi, Francesco Fiz, Selene Capitanio, Matteo Bauckneht, Giuseppe Cittadini, Gianmario Sambuceti, Silvia Morbelli
In the last decades, in addition to conventional imaging techniques and magnetic resonance imaging (MRI), (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) has been shown to be relevant in the detection and management of breast cancer recurrence in doubtful cases in selected groups of patients. While there are no conclusive data indicating that imaging tests, including FDG PET/CT, produce a survival benefit in asymptomatic patients, FDG PET/CT can be useful for identifying the site of relapse when traditional imaging methods are equivocal or conflicting and for identifying or confirming isolated loco-regional relapse or isolated metastatic lesions...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28740396/antithrombotic-prophylaxis-of-atrial-fibrillation-in-an-italian-real-world-setting-a-retrospective-study
#18
Giuliano Ermini, Valentina Perrone, Chiara Veronesi, Luca Degli Esposti, Giuseppe Di Pasquale
OBJECTIVES: The aims of this study were to assess the prevalence of diagnosed atrial fibrillation (AF), the drug use in patients with AF in terms of antithrombotic (AT) strategies used and the compliance with treatment, and to describe the characteristics of patients affected by AF in relation to treatment. METHODS: The data collected were provided from databases of general practitioners (GPs) of the Local Health Unit of Bologna in Italy. From January 1, 2009, to December 31, 2012, all subjects aged ≥18 years followed by the 44 GPs enrolled in the study were evaluated, and the subjects with a diagnosis of AF were included in the analysis...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28740170/a-galnac-gal-specific-lectin-from-the-sea-mussel-crenomytilus-grayanus-modulates-immune-response-in-macrophages-and-in-mice
#19
Oleg V Chernikov, Wei-Ting Wong, Lan-Hui Li, Irina V Chikalovets, Valentina I Molchanova, Shih-Hsiung Wu, Jiahn-Haur Liao, Kuo-Feng Hua
A GalNAc/Gal-specific lectin (CGL) from the edible mussel Crenomytilus grayanus has been demonstrated to exhibit antibacterial properties. However, the mechanism of immune modulation by CGL in mammalian cells remains unclear. Here, we demonstrated that CGL can activate immune responses in macrophages and in mice. In the in vitro cell models, CGL induced tumour necrosis factor-α and interleukin-6 secretion in mouse RAW264.7 macrophages, mouse bone marrow-derived macrophages, human THP-1 macrophages, human peripheral blood mononuclear cells and human blood monocyte-derived macrophages...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28739735/knockdown-of-epha1-using-crispr-cas9-suppresses-aggressive-properties-of-ovarian-cancer-cells
#20
Yuxin Cui, B O Wu, Valentina Flamini, Bronwen A J Evans, Deshan Zhou, Wen G Jiang
BACKGROUND/AIM: Overexpression of erythropoietin-producing hepatocellular A1 (EPHA1), a member of the EPH super family, is frequently observed in various cancer types. The dysregulated interaction of EPHA1 with its ligand Ephrin A1 has been linked to the progression of ovarian cancer (OC). However, the contribution of EPHA1 in the regulation of the aggressive properties of OC cells remains unknown. MATERIALS AND METHODS: In this study we investigated the differential expression of EPHA1 in human OC cells...
August 2017: Anticancer Research
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