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Psoriasis diabetes

Tetsuya Yamamoto, Tsuneaki Kenzaka, Shimpei Mizuki, Yuki Nakashima, Houu Kou, Motoyoshi Maruo, Hozuka Akita
BACKGROUND: We present an extremely rare case of tubo-ovarian abscesses involving Corynebacterium striatum (C. striatum) as causative agent in a 53-year-old woman. CASE PRESENTATION: The patient presented with stomach pain, chills, and nausea. Her medical history included poorly controlled psoriasis vulgaris and diabetes. Laboratory and imaging findings led to diagnosis of septic shock due to tubo-ovarian abscesses. She was treated with antibiotic therapy and surgery to remove the left adnexa...
September 29, 2016: BMC Infectious Diseases
Shivaprasad H Venkatesha, Kamal D Moudgil
Celastrol, a triterpenoid derived from traditional Chinese medicinal plants, has anti-inflammatory, antioxidant, and anticancer activities. Celastrol has shown preventive/therapeutic effects in experimental models of several chronic diseases. These include, chronic inflammatory and autoimmune diseases (e.g., rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, inflammatory bowel disease, and psoriasis), neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis), atherosclerosis, obesity, Type 2 diabetes, and cancer...
2016: Advances in Experimental Medicine and Biology
Mariagrazia Granata, Evangelia Skarmoutsou, Chiara Trovato, Giulio A Rossi, Maria Clorinda Mazzarino, Fabio D'Amico
Obesity, type 1 diabetes, and psoriasis are wide-ranging health problems. Genetics, epigenetics, and environmental factors together with immune disturbances are involved in these diseases. The white adipose tissue is an active endocrine organ, secreting a wide variety of soluble mediators called adipokines that have a central role in the relationship between adipose tissue and immune system. Inflammatory cytokines, including the IL-23/IL-17 and IL-18 axes, and microRNAs are involved in many processes, including immunity and inflammation, thus having a major role in the onset of these three diseases...
September 17, 2016: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
Matteo Megna, Antonio Lobasso, Maddalena Napolitano, Francesca Wanda Rossi, Anna Balato, Caterina Matucci-Cerinic, Francesco Braconaro, Francesca Prignano, Giuseppe Monfrecola, Nicola Balato, Amato De Paulis
Psoriasis is a systemic disease linked to a general state of inflammation and increased risk to develop metabolic and cardiovascular diseases such as obesity, diabetes, and hypertension.(1,2) Physical activity, a vital component in prevention and management of these diseases, is reported to be potentially associated in a negative way with psoriasis, since the latter often cause significant restriction of social activities.(3) The interest in the relationship between exercise and psoriasis is constantly growing...
September 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Sarah M Bronner, Jason R Zbieg, James J Crawford
INTRODUCTION: The transcription factor RORγ plays a critical role in the expression of pro-inflammatory cytokine interleukin IL-17 and is therefore an attractive target for the treatment of inflammatory diseases. Interest in this molecular target has been heightened by the advancement of orally and topically administered RORγ modulators into clinical trials. AREAS COVERED: The present review seeks to summarize published patent applications from assignee companies that have disclosed Investigational New Drug (IND) filings for small molecule RORγ/RORγt antagonists and inverse agonists...
September 15, 2016: Expert Opinion on Therapeutic Patents
Jillian Frieder, Caitriona Ryan
Psoriasis is associated with an increased risk of cardiovascular disease and related comorbidities such as diabetes mellitus, metabolic syndrome, dyslipidemia, and obesity. The precise mechanistic links underlying the association between psoriasis and cardiovascular disease remain unknown, however, multiple pathologic mechanisms have been proposed. Shared inflammatory pathways between psoriasis and atherosclerosis are likely involved. Other possible mechanisms include endothelial dysfunction, cytokine dysregulation, platelet upregulation, and dyslipidemia...
September 14, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Selda Işik, Sevilay Kılıç, Zerrin Öğretmen, Dilek Ülker Çakır, Hakan Türkön, Sibel Cevizci, Meliha Merve Hız
INTRODUCTION: Ischemia-modified albumin (IMA), a novel ischemia marker, and mean platelet volume (MPV), a determinant of platelet activation, have been reported as elevated markers in cardiovascular risk factors such as atherosclerosis, metabolic syndrome, diabetes mellitus (DM), hypertension, and dyslipidemia. As psoriasis is a chronic inflammatory disease having comorbidities, IMA and MPV can help determine the risk factors for psoriasis. AIM: To investigate the correlation between the psoriasis area severity index (PASI), IMA and MPV levels in patients with psoriasis...
August 2016: Postȩpy Dermatologii i Alergologii
Katarzyna Bańska-Kisiel, Maciej Haberka, Beata Bergler-Czop, Ligia Brzezińska-Wcisło, Bogusław Okopień, Zbigniew Gąsior
INTRODUCTION: Psoriasis is a chronic inflammatory disease associated with a significantly higher morbidity and various comorbidities (obesity, metabolic syndrome, diabetes). Previous studies focused mainly on patients with severe psoriasis who were found to have increased markers of early atherosclerosis, higher intima-media thickness (IMT) values. AIM: To evaluate the association between the severity or duration of psoriasis and carotid IMT in patients with mild and moderate psoriasis...
August 2016: Postȩpy Dermatologii i Alergologii
Deeksha Singh, Uttam Singh Baghel, Anshoo Gautam, Dheeraj Singh Baghel, Divya Yadav, Jai Malik, Rakesh Yadav
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Anogeissus (axlewood tree, ghatti tree, button tree and chewing stick tree) belongs to Combretaceae, includes eight species that are distributed in Asia and Africa. Plants are used as an ethnomedicine in Asia and Africa to treat various ailments like diabetes, fever, diarrhoea, dysentery, tuberculosis, wound healing, skin diseases (eczema, psoriasis), snake and scorpion venom. Based on the traditional knowledge, different phytochemical and pharmacological activities have been at the focus of research...
August 23, 2016: Journal of Ethnopharmacology
Bobbak Mansouri, Dario Kivelevitch, Balaji Natarajan, Aditya A Joshi, Caitriona Ryan, Katie Benjegerdes, Jeffrey M Schussler, Daniel J Rader, Muredach P Reilly, Alan Menter, Nehal N Mehta
Importance: Psoriasis is associated with an increased risk of cardiovascular diseases. Subclinical atherosclerosis in patients with psoriasis has not been compared with other conditions associated with increased cardiovascular risk and more rigorous cardiovascular disease screening, such as type 2 diabetes. Objective: To assess the burden of asymptomatic coronary atherosclerosis measured by coronary artery calcium score in patients with moderate to severe psoriasis compared with patients with type 2 diabetes and healthy controls...
August 24, 2016: JAMA Dermatology
T Hillary, J Gutermuth
Psoriasis is a frequent skin disease with a prevalence up to 3% in Western populations. In recent years, it has been demonstrated that the prevalence of metabolic syndrome in psoriasis patients is increased up to three times compared to the general population.(1) The risk of associated conditions, including dyslipidaemia, visceral obesity and diabetes in psoriasis patients positively correlates to the severity of the skin disease.(2) Moreover, it is well known that male obesity is associated with hypogonadism, partially due to elevated P450 aromatase activity in fatty tissue, responsible for metabolizing testosterone into estrogen...
August 24, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Kerstin Wolk, Robert Sabat
Psoriasis is a chronic inflammatory skin disease most common in Europe, North America, and Australia. The etiology and pathomechanisms underlying the evolution and persistence of the skin alterations are increasingly being understood and have led to the development of effective anti-psoriatic therapies. Apart from the skin manifestations, psoriasis is associated with the metabolic syndrome (MetS), known to increase the risk of type 2 diabetes mellitus and cardiovascular disorders. Research of the last years demonstrated a dysregulated adipokine balance as an important link between inflammation, MetS, and consequential disorders...
August 23, 2016: Reviews in Endocrine & Metabolic Disorders
Craig Leonardi, Jerry Bagel, Paul Yamauchi, David Pariser, Zhenyi Xu, Anders Moller, Marie Louise Osterdal, Linda Stein Gold
INTRODUCTION: Psoriasis has a major impact on patient quality of life, similar to that seen in other chronic diseases, eg, diabetes. Health-related quality of life (HRQoL) measures are commonly included in clinical trial designs, capturing the disease burden and therapeutic success of a treatment. In the randomized, double-blind, phase III PSO-FAST (<b>Pso</b>riasis vulgaris, a <b>F</b>our-week, vehicle-controlled, efficacy <b>A</b>nd <b>S</b>afety <b>T</b>rial) study (nCT01866163), fixed combination calcipotriene (Cal) 0...
August 1, 2016: Journal of Drugs in Dermatology: JDD
Suad AlFadhli, Alaa A M Al-Zufairi, Rasheeba Nizam, Huda A AlSaffar, Nawaf Al-Mutairi
The purpose of our study was to identify the currently lacking molecular mechanism that accounts for the co-occurrence of two seemingly disparate diseases: psoriasis and type II diabetes. We aimed to investigate a panel of 84 genes related to the diabetic regulatory network in psoriasis (Ps), psoriasis type II diabetes (Ps-T2D), type II diabetes (T2D) and healthy control (HC). We hypothesize that such attempts would provide novel diagnostic markers and/or insights into pathogenesis of the disease. A quantitative Real Time-PCR Human Diabetes RT(2) Profiler PCR Array was chosen to explore the expression profile 84 diabetic genes in study subjects...
November 15, 2016: Gene
Jinlong Jian, Guangfei Li, Aubryanna Hettinghouse, Chuanju Liu
Autoimmune disease encompasses an array of conditions with a variety of presentations and the involvement of multiple organs. Though the etiologies of many autoimmune conditions are unclear, uncontrolled inflammatory immune response is believed to be a major cause of disease development and progression. Progranulin (PGRN), an anti-inflammatory molecule with therapeutic effect in inflammatory arthritis, was identified as an endogenous antagonist of TNFα by competitively binding to TNFR. PGRN exerts its anti-inflammatory activity through multiple pathways, including induction of Treg differentiation and IL-10 expression and inhibition of chemokine release from macrophages...
August 12, 2016: Cytokine
M A Radtke, I Schäfer, G Glaeske, A Jacobi, M Augustin
BACKGROUND: Most data suggesting an association between psoriasis and cardiovascular disease (CVD) have come from specialized populations at either low or high risk of CVD. Atopic dermatitis (AD) has been associated with a number of modifiable risk factors, particularly obesity. There has been a recent controversy on the suggestion that associations with comorbidities in psoriasis may be due to overreporting or biased by disease severity and therefore not necessarily representative of the general psoriasis population...
August 13, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
E Papadavid, P Katsimbri, I Kapniari, D Koumaki, A Karamparpa, M Dalamaga, K Tzannis, D Βoumpas, D Rigopoulos
OBJECTIVES: To evaluate the prevalence and its clinical characteristics of psoriatic arthritis (PsA) in a specialized psoriasis clinic of a University Hospital. METHODS: In this retrospective study, 278 patients with psoriasis were evaluated between 2011 and 2013. RESULTS: The study included 278 patients with psoriasis: 144 (52%) were male and 134 (48%) female. Their median age was 51.41 with median psoriasis presenting age of 34.52 years...
August 10, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Nadeem Ahmed, James A Prior, Ying Chen, Richard Hayward, Christian D Mallen, Samantha L Hider
The aim of this study is to compare the prevalence of cardiovascular (CVD)-related comorbidities in patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA) or psoriasis (Ps) in UK primary care against matched cohorts. Matched retrospective cohort study used a primary care consultation database. Three cohorts were constructed using all patients with a Read code diagnosis of AS, PsA or Ps between 1999 and 2009; each cohort was then compared in a 1:4 ratio to a matched cohort. The prevalence of CVD-related comorbidities (hypertension, ischaemic heart disease, hyperlipidaemia and diabetes mellitus) were identified by the first consultation of a comorbid Read code, in those with an inflammatory condition of interest...
August 2, 2016: Clinical Rheumatology
Louis Jacob, Karel Kostev
AIM: To analyze psoriasis risk in type 2 diabetes mellitus (T2DM) patients treated in German primary care practices. METHODS: The study included 87,964 T2DM patients aged 40 years or over who received their initial diabetes diagnosis between 2004 and 2013. Patients were excluded if they had been diagnosed with psoriasis prior to diabetes diagnosis or if the observation period prior to the index date was less than 365 days. After applying these exclusion criteria, 72,148 T2DM patients were included...
July 23, 2016: Primary Care Diabetes
E Theodorakopoulou, Z Z N Yiu, C Bundy, L Chularojanamontri, M Gittins, L A Jamieson, L Motta, R B Warren, C E M Griffiths
BACKGROUND: There is accumulating evidence that early onset psoriasis (EOP; presenting at or before 40 years of age) and late onset psoriasis (LOP; presenting after 40 years of age) are different diseases. OBJECTIVES AND METHODS: We aimed to identify potential differences between EOP and LOP by assessing immunocytochemistry involved (PP) and uninvolved (PN) skin (n=31) and demographics, psoriasis phenotype and psychological parameters (n=340) in a cross-sectional study...
July 26, 2016: British Journal of Dermatology
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