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Psoriasis diabetes

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https://www.readbyqxmd.com/read/27888057/association-of-rs2294020-in-the-x-linked-ccdc22-with-susceptibility-to-autoimmune-diseases-with-focus-on-systemic-lupus-erythematosus
#1
Fabio D'Amico, Evangelia Skarmoutsou, Lauren J Lo, Mariagrazia Granata, Chiara Trovato, Giulio A Rossi, Chiara Bellocchio, Maurizio Marchini, Raffaella Scorza, Maria Clorinda Mazzarino, Alon Keinan
Autoimmune diseases often share common susceptibility genes. Most genetic variants associated with susceptibility to systemic lupus erythematosus are also associated with other autoimmune diseases. The X-linked variant rs2294020 is positioned in exon 7 of the CCDC22 gene. The encoded protein functions in the regulation of NF-kB, a master regulator in immune response. The aim of this study is to investigate whether the rs2294020 polymorphism may be a general susceptibility factor for autoimmunity. We evaluated case-control association between the occurrence of rs2294020 and different autoimmune diseases, including new data for systemic lupus erythematosus and previous genome-wide association studies (GWAS) (though most did not analyse the X chromosome) of psoriasis, celiac disease, Crohn's disease, ulcerative colitis, multiple sclerosis, vitiligo, type-1 diabetes, rheumatoid arthritis, and ankylosing spondylitis...
November 22, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27867753/diabetic-wounds-exhibit-decreased-ym1-and-arginase-expression-with-increased-expression-of-il-17-and-il-20
#2
Phillip J Finley, Cory E DeClue, Scott A Sell, Joseph M DeBartolo, Laurie P Shornick
Objective: Impaired wound healing in diabetic (DB) patients is a significant health problem; however, the roles that cytokines and innate immune cells contribute to this impaired healing are not completely understood. Approach: A mouse model was used to compare the innate immune response during DB and normal wound healing. Two 5-mm full-thickness wounds were created on the dorsal skin of BKS.Cg-m+/+Leprdb/J (DB) and C57BL/6 (wild-type) mice. Innate immune cell markers and cytokine mRNA levels were measured in wound biopsies during the first week of healing...
November 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27864954/prevalence-of-comorbidity-and-associated-risk-factors-in-adults-with-atopic-dermatitis
#3
Alexander Egeberg, Yuki M F Andersen, Gunnar H Gislason, Lone Skov, Jacob P Thyssen
BACKGROUND: Atopic dermatitis (AD) is a common chronic skin disorder, which may persist into adulthood, however the prevalence of comorbidities in patients with AD is not well characterized. AD is considered a systemic disorder like psoriasis, which has raised a need for data on the comorbidity profile of patients with AD, to assess the potential risks, benefits, and complications in management of patients with AD. We described the occurrence of medical and psychiatric comorbidities and associated risk factors in adults with AD compared with psoriasis and the general population...
November 16, 2016: Allergy
https://www.readbyqxmd.com/read/27859474/polyglandular-autoimmune-syndrome-type-iii-with-a-prevalence-of-cutaneous-features
#4
A Capo, P Amerio
Polyglandular autoimmune syndrome (PAS) is the name given to a group of autoimmune disorders of the endocrine glands. PAS type III (PAS III) comprises several autoimmune diseases (autoimmune thyroiditis, immune-mediated diabetes mellitus, pernicious anaemia, vitiligo, alopecia areata and many others) and is subdivided into four subcategories. We report the case of a 52-year-old woman with autoimmune thyroiditis, vitiligo, alopecia areata, psoriasis and lichen sclerosus, suggesting a clinical diagnosis of PAS IIIC with a singular prevalence of cutaneous features...
November 13, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27859213/role-of-wnt5a-in-the-pathogenesis-of-inflammatory-diseases
#5
REVIEW
Mehran Pashirzad, Mojtaba Shafiee, Farzad Rahmani, Reihane Behnam-Rassouli, Fatemeh Hoseinkhani, Mikhail Ryzhikov, Maryam Moradi Binabaj, Mohammad Reza Parizadeh, Amir Avan, Seyed Mahdi Hassanian
Wnt5a initiates pro-inflammatory responses through activation of non-canonical Wnt signaling pathway. Pro-inflammatory functions of Wnt5a trigger pro-inflammatory signaling cascades and increase secretion of pro-inflammatory cytokines and chemokines. Wnt5a as a potent signaling molecule is strongly implicated in a number of diseases including cancer, diabetes, metabolic disorders, and of special interest in this review, inflammatory diseases. This review summarizes the role of Wnt5a in the pathogenesis of inflammatory diseases including atherosclerosis, rheumatoid arthritis, psoriasis vulgaris and sepsis, promoting greater understanding and clinical management of these diseases...
November 11, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27835645/pocos-population-covering-locus-sets-for-risk-assessment-in-complex-diseases
#6
Marzieh Ayati, Mehmet Koyutürk
: Susceptibility loci identified by GWAS generally account for a limited fraction of heritability. Predictive models based on identified loci also have modest success in risk assessment and therefore are of limited practical use. Many methods have been developed to overcome these limitations by incorporating prior biological knowledge. However, most of the information utilized by these methods is at the level of genes, limiting analyses to variants that are in or proximate to coding regions...
November 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27832688/changes-in-body-mass-index-and-lipid-profile-in-psoriatic-patients-after-treatment-with-standard-protocol-of-infliximab
#7
Amir Houshang Ehsani, Hossein Mortazavi, Kamran Balighi, Mahboubeh Sadat Hosseini, Arghavan Azizpour, Seyyedeh Pardis Hejazi, Azadeh Goodarzi, Seyyedeh Bahareh Darvari
Psoriasis is a chronic and inflammatory dermatologic disease. Psoriasis may predispose to cardiovascular disease and diabetes. However, the role of tumor necrosis factor (TNF) inhibitor in mediating this risk is controversial. Regarding frequent use of infliximab in psoriasis, and the hypothesis that anti TNF-α treatment may increase Body Mass Index (BMI) and alter lipid profile in these patients, the aim of this study was to assess changes in BMI and Lipid Profile and level of leptin in Psoriatic Patients under Treatment of Standard Protocol of Infliximab in a 24 week period...
September 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/27815622/-cutaneous-manifestations-of-metabolic-syndrome
#8
REVIEW
G Holzer, B Straßegger, B Volc-Platzer
BACKGROUND: Metabolic syndrome (MetS) is a cluster of risk factors which increase the risk of developing cardiovascular diseases and type II diabetes mellitus. High blood pressure, hyperglycemia, dyslipidemia, and central obesity are the main risk factors. While MetS is not a dermatological diagnosis per se, several cutaneous manifestations can serve as a clinical indicator for impending MetS and facilitate an early diagnosis and therapy in order to prevent its long-term sequelae...
December 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27786588/serum-irisin-levels-in-patients-with-psoriasis
#9
A Baran, H Myśliwiec, P Kiluk, M Świderska, I Flisiak
BACKGROUND: Irisin has been proposed to regulate metabolic diseases such as obesity, diabetes or metabolic syndrome which are common comorbidities in psoriasis. OBJECTIVES: The aim of this study was to evaluate the serum irisin level in psoriasis and elucidate possible associations with disease activity, inflammatory or metabolic parameters and topical treatment. METHODS: Thirty-seven individuals with active plaque-type psoriasis and 15 healthy controls were enrolled...
October 27, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27686475/an-extremely-rare-case-of-tubo-ovarian-abscesses-involving-corynebacterium-striatum-as-causative-agent
#10
Tetsuya Yamamoto, Tsuneaki Kenzaka, Shimpei Mizuki, Yuki Nakashima, Houu Kou, Motoyoshi Maruo, Hozuka Akita
BACKGROUND: We present an extremely rare case of tubo-ovarian abscesses involving Corynebacterium striatum (C. striatum) as causative agent in a 53-year-old woman. CASE PRESENTATION: The patient presented with stomach pain, chills, and nausea. Her medical history included poorly controlled psoriasis vulgaris and diabetes. Laboratory and imaging findings led to diagnosis of septic shock due to tubo-ovarian abscesses. She was treated with antibiotic therapy and surgery to remove the left adnexa...
September 29, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27671821/celastrol-and-its-role-in-controlling%C3%A2-chronic-diseases
#11
Shivaprasad H Venkatesha, Kamal D Moudgil
Celastrol, a triterpenoid derived from traditional Chinese medicinal plants, has anti-inflammatory, antioxidant, and anticancer activities. Celastrol has shown preventive/therapeutic effects in experimental models of several chronic diseases. These include, chronic inflammatory and autoimmune diseases (e.g., rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, inflammatory bowel disease, and psoriasis), neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis), atherosclerosis, obesity, Type 2 diabetes, and cancer...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27639922/obesity-type-1-diabetes-and-psoriasis-an-autoimmune-triple-flip
#12
Mariagrazia Granata, Evangelia Skarmoutsou, Chiara Trovato, Giulio A Rossi, Maria Clorinda Mazzarino, Fabio D'Amico
Obesity, type 1 diabetes, and psoriasis are wide-ranging health problems. Genetics, epigenetics, and environmental factors together with immune disturbances are involved in these diseases. The white adipose tissue is an active endocrine organ, secreting a wide variety of soluble mediators called adipokines that have a central role in the relationship between adipose tissue and immune system. Inflammatory cytokines, including the IL-23/IL-17 and IL-18 axes, and microRNAs are involved in many processes, including immunity and inflammation, thus having a major role in the onset of these three diseases...
September 17, 2016: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27632580/soccer-helps-in-controlling-the-development-of-psoriasis-in-italian-second-league-players
#13
Matteo Megna, Antonio Lobasso, Maddalena Napolitano, Francesca Wanda Rossi, Anna Balato, Caterina Matucci-Cerinic, Francesco Braconaro, Francesca Prignano, Giuseppe Monfrecola, Nicola Balato, Amato De Paulis
Psoriasis is a systemic disease linked to a general state of inflammation and increased risk to develop metabolic and cardiovascular diseases such as obesity, diabetes, and hypertension.(1,2) Physical activity, a vital component in prevention and management of these diseases, is reported to be potentially associated in a negative way with psoriasis, since the latter often cause significant restriction of social activities.(3) The interest in the relationship between exercise and psoriasis is constantly growing...
September 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27629281/ror%C3%AE-antagonists-and-inverse-agonists-a-patent-review
#14
Sarah M Bronner, Jason R Zbieg, James J Crawford
INTRODUCTION: The transcription factor RORγ plays a critical role in the expression of pro-inflammatory cytokine interleukin IL-17 and is therefore an attractive target for the treatment of inflammatory diseases. Interest in this molecular target has been heightened by the advancement of orally and topically administered RORγ modulators into clinical trials. AREAS COVERED: The present review seeks to summarize published patent applications from assignee companies that have disclosed Investigational New Drug (IND) filings for small molecule RORγ/RORγt antagonists and inverse agonists...
September 15, 2016: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/27627099/psoriasis-and-cardiovascular-disorders
#15
Jillian Frieder, Caitriona Ryan
Psoriasis is associated with an increased risk of cardiovascular disease and related comorbidities such as diabetes mellitus, metabolic syndrome, dyslipidemia, and obesity. The precise mechanistic links underlying the association between psoriasis and cardiovascular disease remain unknown, however, multiple pathologic mechanisms have been proposed. Shared inflammatory pathways between psoriasis and atherosclerosis are likely involved. Other possible mechanisms include endothelial dysfunction, cytokine dysregulation, platelet upregulation, and dyslipidemia...
September 14, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27605901/the-correlation-between-the-psoriasis-area-severity-index-and-ischemia-modified-albumin-mean-platelet-volume-levels-in-patients-with-psoriasis
#16
Selda Işik, Sevilay Kılıç, Zerrin Öğretmen, Dilek Ülker Çakır, Hakan Türkön, Sibel Cevizci, Meliha Merve Hız
INTRODUCTION: Ischemia-modified albumin (IMA), a novel ischemia marker, and mean platelet volume (MPV), a determinant of platelet activation, have been reported as elevated markers in cardiovascular risk factors such as atherosclerosis, metabolic syndrome, diabetes mellitus (DM), hypertension, and dyslipidemia. As psoriasis is a chronic inflammatory disease having comorbidities, IMA and MPV can help determine the risk factors for psoriasis. AIM: To investigate the correlation between the psoriasis area severity index (PASI), IMA and MPV levels in patients with psoriasis...
August 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27605900/carotid-intima-media-thickness-in-patients-with-mild-or-moderate-psoriasis
#17
Katarzyna Bańska-Kisiel, Maciej Haberka, Beata Bergler-Czop, Ligia Brzezińska-Wcisło, Bogusław Okopień, Zbigniew Gąsior
INTRODUCTION: Psoriasis is a chronic inflammatory disease associated with a significantly higher morbidity and various comorbidities (obesity, metabolic syndrome, diabetes). Previous studies focused mainly on patients with severe psoriasis who were found to have increased markers of early atherosclerosis, higher intima-media thickness (IMT) values. AIM: To evaluate the association between the severity or duration of psoriasis and carotid IMT in patients with mild and moderate psoriasis...
August 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27566202/the-genus-anogeissus-a-review-on-ethnopharmacology-phytochemistry-and-pharmacology
#18
Deeksha Singh, Uttam Singh Baghel, Anshoo Gautam, Dheeraj Singh Baghel, Divya Yadav, Jai Malik, Rakesh Yadav
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Anogeissus (axlewood tree, ghatti tree, button tree and chewing stick tree) belongs to Combretaceae, includes eight species that are distributed in Asia and Africa. Plants are used as an ethnomedicine in Asia and Africa to treat various ailments like diabetes, fever, diarrhoea, dysentery, tuberculosis, wound healing, skin diseases (eczema, psoriasis), snake and scorpion venom. Based on the traditional knowledge, different phytochemical and pharmacological activities have been at the focus of research...
August 23, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27556410/comparison-of-coronary-artery-calcium-scores-between-patients-with-psoriasis-and-type-2-diabetes
#19
Bobbak Mansouri, Dario Kivelevitch, Balaji Natarajan, Aditya A Joshi, Caitriona Ryan, Katie Benjegerdes, Jeffrey M Schussler, Daniel J Rader, Muredach P Reilly, Alan Menter, Nehal N Mehta
Importance: Psoriasis is associated with an increased risk of cardiovascular diseases. Subclinical atherosclerosis in patients with psoriasis has not been compared with other conditions associated with increased cardiovascular risk and more rigorous cardiovascular disease screening, such as type 2 diabetes. Objective: To assess the burden of asymptomatic coronary atherosclerosis measured by coronary artery calcium score in patients with moderate to severe psoriasis compared with patients with type 2 diabetes and healthy controls...
August 24, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27556231/should-psoriasis-be-considered-a-risk-factor-for-hypogonadism-in-male-patients-a-monocentric-prospective-observational-pilot-study
#20
T Hillary, J Gutermuth
Psoriasis is a frequent skin disease with a prevalence up to 3% in Western populations. In recent years, it has been demonstrated that the prevalence of metabolic syndrome in psoriasis patients is increased up to three times compared to the general population.(1) The risk of associated conditions, including dyslipidaemia, visceral obesity and diabetes in psoriasis patients positively correlates to the severity of the skin disease.(2) Moreover, it is well known that male obesity is associated with hypogonadism, partially due to elevated P450 aromatase activity in fatty tissue, responsible for metabolizing testosterone into estrogen...
August 24, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
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