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Cervical ectopic

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https://www.readbyqxmd.com/read/29349699/to-evaluate-the-feasibility-of-magnetic-resonance-imaging-in-predicting-unusual-site-ectopic-pregnancy-a-retrospective-cohort-study
#1
Gabriele Masselli, Martina Derme, Maria Grazia Piccioni, Vincenzo Spina, Francesca Laghi, Gianfranco Gualdi, Marialuisa Framarino-Dei-Malatesta
OBJECTIVE: To evaluate the accuracy of pelvic MRI in the diagnosis of unusual ectopic pregnancy (EP), when ultrasound (US) examination is inconclusive. METHODS: We retrospectively reviewed the medical records of 150 patients with suspected EP. Clinical, US and MRI features of 15 unusual EPs were analysed. Two radiologists independently reviewed each case resolving by consensus any diagnostic discrepancy. Interobserver agreement was assessed using the Cohen κ test...
January 18, 2018: European Radiology
https://www.readbyqxmd.com/read/29339538/e6-protein-expressed-by-high-risk-hpv-activates-super-enhancers-of-the-egfr-and-c-met-oncogenes-by-destabilizing-the-histone-demethylase-kdm5c
#2
Xiaohua Chen, Jun Xian Loo, Xin Shi, Wenjun Xiong, Yong Guo, Haiqiang Ke, Mingkun Yang, Yanping Jiang, Siyu Xia, Min Zhao, Shan Zhong, ChunJiang He, Li Fu, Feng Li
The high-risk (HR) human papillomaviruses (HPV) are causative agents of anogenital tract dysplasia and cancers and a fraction of head and neck cancers. The HR HPV E6 oncoprotein possesses canonical oncogenic functions, such as p53 degradation and telomerase activation. It is also capable of stimulating expression of several oncogenes, but the molecular mechanism underlying these events are poorly understood. Here we provide evidence that HPV16 E6 physically interacts with histone H3K4 demethylase KDM5C, resulting in its degradation in an E3 ligase E6AP- and proteasome-dependent manner...
January 16, 2018: Cancer Research
https://www.readbyqxmd.com/read/29316709/screaming-body-and-silent-healthcare-providers-a-case-study-with-a-childhood-sexual-abuse-survivor
#3
REVIEW
Sigrun Sigurdardottir, Sigridur Halldorsdottir
Stressful early life experiences cause immune dysregulation across the lifespan. Despite the fact that studies have identified childhood sexual abuse (CSA) survivors as a particularly vulnerable group, only a few attempts have been made to study their lived-experience of the physical health consequences of CSA. The aim of this study was to explore a female CSA survivor's lived-experience of the physical health consequences of CSA and how she experienced the reactions of healthcare providers. Seven interviews were conducted with this 40-year-old woman, Anne, using a phenomenological research approach...
January 8, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29312764/ectopic-thymoma-managed-by-neck-dissection-video-assisted-thoracoscopic-thymectomy
#4
John K Peel, Eitan Prisman, Tony L Ng, Anna L McGuire
Ectopic thymoma in the neck is a rare phenomenon, with fewer than 20 cases reported worldwide. Evidence for management of ectopic thymoma comes from literature for mediastinal thymoma despite clinical features that distinguish the two. Here we present a case of a 31-year-old female with an asymptomatic neck mass who was found to have an ectopic cervical thymoma with concomitant mediastinal thymic hyperplasia. The decision was made to perform a left-sided neck dissection and a video-assisted thoracoscopic surgery (VATS) thymectomy...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29290953/viral-e6-e7-oncogene-and-cellular-hexokinase-2-expression-in-hpv-positive-cancer-cell-lines
#5
Karin Hoppe-Seyler, Anja Honegger, Felicitas Bossler, Jasmin Sponagel, Julia Bulkescher, Claudia Lohrey, Felix Hoppe-Seyler
Oncogenic types of human papillomaviruses (HPVs) are major human carcinogens. Cancer cells typically exhibit metabolic alterations which support their malignant growth. These include an enhanced rate of aerobic glycolysis ('Warburg effect') which in cancer cells is often linked to an increased expression of the rate-limiting glycolytic enzyme Hexokinase 2 (HK2). Intriguingly, recent studies indicate that the HPV E6/E7 oncogenes cause the metabolic reprogramming in HPV-positive cancer cells by directly upregulating HK2 expression...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29285171/microrna-10a-5p-suppresses-cancer-proliferation-and-division-in-human-cervical-cancer-by-targeting-bdnf
#6
Liancheng Zhai, Yanli Li, Xinzhi Lan, Liang Ai
The aim of the present study was to investigate the effect and mechanism of microRNA (miR)-10a-5p in human cervical cancer. The expression level of miR-10-5p in cervical cancer lines was assessed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). In cervical cancer HeLa and SiHa cells, miR-10-5p was ectopically overexpressed by lentiviral transduction. Brain-derived neurotrophic factor (BDNF) was then overexpressed in HeLa and SiHa cells to evaluate its selective effect on miR-10-5p in cervical cancer modulation...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29218126/a-pilot-study-comparing-hysteroscopic-adhesiolysis-by-conventional-resectoscope-versus-mini-resectoscope
#7
Kallol Kumar Roy, Archana Lingampally, Yamini Kansal, Juhi Bharti, Sunesh Kumar, Perumal Vanamail, Seema Singhal, Jyoti Meena
Objectives: To compare the feasibility and efficacy of the mini-resectoscope with the conventional resectoscope in terms of the operative, menstrual, and reproductive outcome in hysteroscopic adhesiolysis in infertile women. Methods: We conducted a parallel prospective randomized study at All India Institute of Medical Sciences, New Delhi. A total of 60 patients underwent hysteroscopic adhesiolysis using either conventional resectoscope (n = 30) or mini-resectoscope (n = 30)...
November 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29208873/correlation-between-seropositivity-of-chlamydia-trachomatis-and-tubal-and-or-pelvic-pathology-detected-by-diagnostic-laparoscopy-in-subfertile-women
#8
N Begum, S A Anwary, M Alfazzaman, Z Mahzabin, F Deeba, M A Mostafa, M Akhter, M M Rahman
This prospective observational study was carried out in the Infertility Unit, Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from February 2011 to December 2013. Sixty-nine (69) subfertile women who were seropositive for Chlamydia Trachomatis were included in this study. Inclusion criteria was patients with sub-fertility having age between 22 and 40 years, seeking infertility treatment, normal ovarian function, all normozoospermic male partner, duration of infertility ranged from 1...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29170443/should-we-screen-for-the-sexually-transmitted-infection-mycoplasma-genitalium-evidence-synthesis-using-a-transmission-dynamic-model
#9
Ruthie Birger, John Saunders, Claudia Estcourt, Andrew John Sutton, Catherine H Mercer, Tracy Roberts, Peter J White
There is increasing concern about Mycoplasma genitalium as a cause of urethritis, cervicitis, pelvic inflammatory disease (PID), infertility and ectopic pregnancy. Commercial nucleic acid amplification tests (NAATs) are becoming available, and their use in screening for M. genitalium has been advocated, but M. genitalium's natural history is poorly-understood, making screening's effectiveness unclear. We used a transmission-dynamic compartmental model to synthesise evidence from surveillance data and epidemiological and behavioural studies to better understand M...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29156233/trans-cervical-resection-of-a-separate-substernal-goitre
#10
Henry To, Antara Karmakar, Stephen Farrell, Steve Manolas
INTRODUCTION: A separate substernal goitre which is not continuous with the main cervical thyroid proves a unique challenge for resection. A trans-cervical approach is preferred but may be hazardous due to the possibility of ectopic thyroid tissue with alternate blood supply. PRESENTATION OF CASE: A 72year old female who had a previous left hemithyroidectomy presents with a symptomatic central substernal thyroid mass. Following radiological work-up, the separate goitre was carefully removed via a trans-cervical approach and avoidance of sternotomy...
November 10, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29120527/castle-tumor-of-the-parotid-first-documented-case-literature-review-and-genetic-analysis-of-the-cancer
#11
Eugene Hung Chih Wong, Nora Tetter, Alexandar Tzankov, Laurent Muller
BACKGROUND: Carcinoma showing thymus-like elements (CASTLE) is a rare tumor that normally affects the thyroid gland and was thought to arise from either the remnants of the branchial pouch or the ectopic cervical thymic tissue. These tumors show strong immunopositivity for CD5, P63, and CD117. Most CASTLE of the thyroid gland is treated with surgery with or without adjuvant radiotherapy or chemotherapy. METHOD: A 55-year-old woman presented with a slow-growing right parotid mass...
November 9, 2017: Head & Neck
https://www.readbyqxmd.com/read/29118270/upregulation-of-pir-gene-expression-induced-by-human-papillomavirus-e6-and-e7-in-epithelial-oral-and-cervical-cells
#12
Diego Carrillo, Juan P Muñoz, Hernán Huerta, Gabriel Leal, Alejandro Corvalán, Oscar León, Gloria M Calaf, Ulises Urzúa, Enrique Boccardo, Julio C Tapia, Francisco Aguayo
The hallmark of high-risk human papillomavirus (HR-HPV)-related carcinogenesis is E6 and E7 oncogene overexpression. The aim of this work was to characterize epithelial oral and cervical cancer cells that express HR-HPV E6 and E7 oncoproteins. Transcriptomic assay using DNA microarrays revealed that PIR gene expression was detected in oral cells in an HR-HPV E6/E7-dependent manner. In addition, PIR was overexpressed in HPV-positive SiHa and Ca Ski cells, whereas it was undetectable in HPV-negative C33A cells...
November 2017: Open Biology
https://www.readbyqxmd.com/read/29078646/extended-thymectomy-by-a-cervical-incision-additional-to-bilateral-vats-approach
#13
Liang Xue, Xuguang Pang, Yongxing Zhang, Jianyong Ding
BACKGROUND: Video-assisted thoracoscopic surgery (VATS) in thymectomy has shown safe and effective with many advantages in myasthenia gravis (MG) patients with or without thymoma than transsternal approach. This video aims to show the procedure of extended thymectomy via a cervical incision additional to bilateral VATS approach in a MG patient with an early stage thymoma. METHODS: The patient was a 46-year-old male who had onset of symptoms of blurred vision, dysarthria and dysphagia for 10 months before administration...
2017: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29061638/motor-neurons-with-limb-innervating-character-in-the-cervical-spinal-cord-are-sculpted-by-apoptosis-based-on-the-hox-code-in-chick-embryo
#14
Katsuki Mukaigasa, Chie Sakuma, Tomoaki Okada, Shunsaku Homma, Takako Shimada, Keiji Nishiyama, Noboru Sato, Hiroyuki Yaginuma
In the developing chick embryo, a certain population of motor neurons (MNs) in the non-limb-innervating cervical spinal cord undergoes apoptosis between embryonic days 4 and 5. However, the characteristics of these apoptotic MNs remain undefined. Here, by examining the spatiotemporal profiles of apoptosis and MN subtype marker expression in normal or apoptosis-inhibited chick embryos, we found that this apoptotic population is distinguishable by Foxp1 expression. When apoptosis was inhibited, the survived Foxp1+ MNs showed characteristics of lateral motor column (LMC) neurons, which are of a limb-innervating subtype, suggesting that cervical Foxp1(+) MNs are the rostral continuation of LMC...
October 23, 2017: Development
https://www.readbyqxmd.com/read/29048632/microrna-1297-inhibits-metastasis-and-epithelial-mesenchymal-transition-by-targeting-aeg-1-in-cervical-cancer
#15
Zengyan Wang, Shanyang He, Peng Guo, Xu Guo, Jingxuan Zheng
Accumulating evidence has demonstrated that aberrant miRNAs contribute to cervical cancer (CC) development and progression. However, the roles of various miRNAs in CC remain to be determined. In the present study, we confirmed that a decreased miR-1297 expression was present in CC tissues and cell lines. Our clinical analysis revealed that the downregulated miR-1297 expression was significantly correlated with poor prognostic features including lymph node metastasis and lymphovascular space invasion. Moreover, we confirmed that miR-1297 was a novel independent prognostic marker for predicting the 5-year survival of CC patients...
September 20, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29023799/mir-214-activates-tp53-but-suppresses-the-expression-of-rela-ctnnb1-and-stat3-in-human-cervical-and-colorectal-cancer-cells
#16
Karthik Subramanian Chandrasekaran, Anusha Sathyanarayanan, Devarajan Karunagaran
High Mobility Group AT-hook 1 (HMGA1) was identified as a target of miR-214 in human cervical and colorectal cancers (CaCx and CRC) in a previous study. While the expression of miR-214 remains suppressed, HMGA1 behaves as a potent oncogene and plays crucial roles in several aberrant signalling pathways by interacting with intermediates like RELA, CTNNB1, STAT3, and TP53 in CaCx and CRC. Hypothetically, miR-214 should be able to regulate the stabilization of some of these intermediates through the regulation of HMGA1...
October 10, 2017: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/28978307/mir-216b-inhibits-cell-proliferation-by-targeting-foxm1-in-cervical-cancer-cells-and-is-associated-with-better-prognosis
#17
Shanyang He, Bing Liao, Yalan Deng, Chang Su, Jiuling Tuo, Jun Liu, Shuzhong Yao, Lin Xu
BACKGROUND: Our previous study showed FOXM1 expression was significantly up-regulated in cervical cancer, and was associated with poor prognosis. To clarify miRNAs-FOXM1 modulation pathways, in this study, we investigated the relationships between miR-216b and FOXM1 and the role of miR-216b in cell proliferation and prognosis of cervical cancer patients. METHODS: Western blotting and qPCR were used to determine expression of FOXM1, cell cycle related factors and miR-216b level...
October 4, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28974881/ectopic-salivary-gland-cyst-in-the-neck-association-with-congenital-plunging-ranula
#18
Nitin Pant, Ajay Kumar Verma, Tanvir Rashan Khan, Ashish Wakhlu
Congenital ranula is rare. We report a large, symptomatic, congenital plunging ranula associated with a salivary gland cyst in the neck. To the best of our knowledge, this is the first such reported case. Even though both the cysts had their origin from the sublingual gland, only the cervical cyst had a capsular covering. Herniation of a part of the immature sublingual gland anlage through a congenital mylohyoid defect, its separation, and subsequent maturation could explain this occurrence.
October 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28968467/kdm6a-addiction-of-cervical-carcinoma-cell-lines-is-triggered-by-e7-and-mediated-by-p21cip1-suppression-of-replication-stress
#19
David R Soto, Christopher Barton, Karl Munger, Margaret E McLaughlin-Drubin
Expression of E7 proteins encoded by carcinogenic, high-risk human papillomaviruses (HPVs) triggers increased expression of the histone H3 lysine 27 demethylase KDM6A. KDM6A expression is necessary for survival of high-risk HPV E7 expressing cells, including several cervical cancer lines. Here we show that increased KDM6A in response to high-risk HPV E7 expression causes epigenetic de-repression of the cell cycle and DNA replication inhibitor p21CIP1, and p21CIP1 expression is necessary for survival of high-risk HPV E7 expressing cells...
October 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28955106/cervical-ectopic-pregnancy-in-resource-deprived-areas-a-rare-and-difficult-diagnosis
#20
Mohammed Mouhajer, Samuel Obed, Amalachukwu M Okpala
Ectopic pregnancy is a common cause of morbidity and mortality in women of reproductive age especially in resource deprived areas worldwide. Cervical ectopic pregnancy is a rare, life threatening form of ectopic pregnancy which needs a high index of suspicion for diagnosis, thus adding a complex twist to the dilemma faced by the obstetrician in resource deprived areas. A case of a cervical ectopic pregnancy which presented in a resource deprived area in a region in Ghana is discussed, and the difficulties encountered in diagnosis and management of this life threatening condition are outlined...
June 2017: Ghana Medical Journal
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