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Cervical ectopic

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https://www.readbyqxmd.com/read/28077648/human-papillomavirus-16-e6-up-regulates-apobec3b-via-the-tead-transcription-factor
#1
Seiichiro Mori, Takamasa Takeuchi, Yoshiyuki Ishii, Takashi Yugawa, Tohru Kiyono, Hiroshi Nishina, Iwao Kukimoto
: The cytidine deaminase APOBEC3B (A3B) underlies the genetic heterogeneity of several human cancers including cervical cancer, which is caused by human papillomavirus (HPV) infection. We previously identified a region within the A3B promoter that is activated by the viral protein HPV16 E6 in human keratinocytes. Here, we discovered three sites recognized by the TEAD family of transcription factors within this region of the A3B promoter. Reporter assays in HEK293 cells showed that exogenously expressed TEAD4 induced A3B promoter activation through binding to these sites...
January 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28059468/gene-expression-analysis-combined-with-functional-genomics-approach-identifies-itih5-as-tumor-suppressor-gene-in-cervical-carcinogenesis
#2
Jessica Dittmann, Angelique Ziegfeld, Lars Jansen, Mieczyslaw Gajda, Vera Kloten, Edgar Dahl, Ingo B Runnebaum, Matthias Dürst, Claudia Backsch
Progression from human papillomavirus-induced premalignant cervical intraepithelial neoplasia (CIN) to cervical cancer (CC) is driven by genetic and epigenetic events. Our microarray-based expression study has previously shown that inter-α-trypsin-inhibitor heavy chain 5 (ITIH5) mRNA levels in CCs were significantly lower than in high-grade precursor lesions (CIN3s). Therefore, we aimed to analyze in depth ITIH5 expression during cervical carcinogenesis in biopsy material and cell culture. Moreover, functional analyses were performed by ectopic expression of ITIH5 in different cell lines...
January 6, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28053597/mir-324-3p-suppresses-migration-and-invasion-by-targeting-wnt2b-in-nasopharyngeal-carcinoma
#3
Chao Liu, Guo Li, Nianting Yang, Zhongwu Su, Shuiting Zhang, Tengbo Deng, Shuling Ren, Shanhong Lu, Yongquan Tian, Yong Liu, Yuanzheng Qiu
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a malignant epithelial carcinoma of the head and neck with strong ability of invasion and metastasis. Our previous study indicated that miR-324-3p, as a tumor-suppressive factor, could regulate radioresistance of NPC cells by targeting WNT2B. The purpose of this study is to investigate the role of miR-324-3p on migration and invasion in NPC cells. METHODS: Quantitative real time PCR was applied to measure the expression level of miR-324-3p and WNT2B mRNA in both cells and tissues, and the expression level of WNT2B protein was determined by western blotting...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/27989102/tazarotene-induced-gene-1-enhanced-cervical-cell-autophagy-through-transmembrane-protein-192
#4
Rong-Yaun Shyu, Chun-Hua Wang, Chang-Chieh Wu, Mao-Liang Chen, Ming-Cheng Lee, Lu-Kai Wang, Shun-Yuan Jiang, Fu-Ming Tsai
Tazarotene-induced gene 1 (TIG1) is a retinoic acid-inducible protein that is considered a putative tumor suppressor. The expression of TIG1 is decreased in malignant prostate carcinoma or poorly differentiated colorectal adenocarcinoma, but TIG1 is present in benign or well-differentiated tumors. Ectopic TIG1 expression led to suppression of growth in cancer cells. However, the function of TIG1 in cell differentiation is still unknown. Using a yeast two-hybrid system, we found that transmembrane protein 192 (TMEM192) interacted with TIG1...
December 2016: Molecules and Cells
https://www.readbyqxmd.com/read/27976570/aberrant-cervical-thymus-and-the-role-of-ultrasonography-a-case-report
#5
Emre Ünal, Hanife Gülden Düzkalır, Seray Kurt-Güney, Emek Tolga Işıldak
Ectopic/aberrant cervical thymic tissue is a rare cause of neck mass and usually detected incidentally. Aberrant thymic tissue can occur anywhere in the course of thymic descent from the angle of the mandible to the superior mediastinum. We report a case of aberrant cervical thymus demonstrated by ultrasound.
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27943496/the-treatment-of-cervical-pregnancy-with-ultrasound-guided-local-methotrexate-injection
#6
Munekage Yamaguchi, Ritsuo Honda, Chimeddulam Erdenebaatar, Mahina Monsur, Tomoko Honda, Isao Sakaguchi, Yoshinori Okamura, Takashi Ohba, Hidetaka Katabuchi
OBJECTIVES: Cervical pregnancy (CP) is a rare type of ectopic pregnancy. Methotrexate (MTX) appears to be the first-line therapy for clinically stable women; however, there is still no consensus on the most appropriate treatment for this abnormal pregnancy. The aim of the present study was to investigate the efficacy of a single local MTX injection under transvaginal ultrasound guidance for the initial treatment of CP and to assess the post-treatment fertility. METHODS: We retrospectively reviewed 15 CP patients treated with local MTX injection under transvaginal ultrasonography...
December 10, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27926641/vaginal-hysterectomy-for-treatment-of-cervical-ectopic-pregnancy
#7
Roa Alammari, Renee Thibodeau, Oz Harmanli
BACKGROUND: Cervical ectopic pregnancy can lead to catastrophic hemorrhage, and may be managed conservatively with intra-amniotic methotrexate (MTX), systemic MTX, or both; surgical evacuation with or without balloon tamponade; and uterine artery embolization. However, some patients require hysterectomy, which has traditionally been performed abdominally. CASE: A 39-year-old parous woman was diagnosed with cervical ectopic pregnancy at an estimated 7 1/7 weeks of gestation...
January 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27894088/lsd1-binds-to-hpv16-e7-and-promotes-the-epithelial-mesenchymal-transition-in-cervical-cancer-by-demethylating-histones-at-the-vimentin-promoter
#8
Yuan Liu, Yanan Wang, Chunqin Chen, Jiawen Zhang, Wenyan Qian, Yu Dong, Zhiqiang Liu, Xi Zhang, Xiaoyun Wang, Zhenbo Zhang, Xiaobing Shi, Sufang Wu
Lysine-specific demethylase 1 (LSD1), which specifically demethylates histone H3 lysine 4 (H3K4) and lysine 9 (H3K9), is dysregulated in several cancers. We found that ectopic expression of LSD1 in cervical cancer cells promoted invasion and metastasis in vitro and in vivo, reduced the expression of the epithelial marker E-cadherin, and induced the expression of the mesenchymal marker, Vimentin. By contrast, LSD1 knockdown had the opposite effect and attenuated the HPV16 E7-induced epithelial-mesenchymal transition (EMT)...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27866035/a-unique-presentation-of-ectopic-thyroid-a-case-report
#9
Erika Allen, Masoud Alzeerah, Stevenson Tsiao, Nail Aydin, Subhasis Misra
INTRODUCTION: This case presents a painful ectopic thyroid, an unusual presentation, in an atypical location. The patient's history of an ingested fish bone, her acute presentation, and inconclusive imaging, made this case a diagnostic dilemma. PRESENTATION OF CASE: 61-year-old female presented with acutely worsening history of left throat pain and dysphagia after swallowing a fish bone. CT scan showed a foreign body in the anterior wall of the cervical esophagus...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27865941/local-injection-of-diluted-vasopressin-followed-by-suction-curettage-for-cervical-ectopic-pregnancy
#10
Hiroshi Ishikawa, Youichi Unno, Akiko Omoto, Makio Shozu
OBJECTIVE: To report the results of local injection of diluted vasopressin followed by suction curettage as a conservative treatment for women with cervical ectopic pregnancy, who wish to preserve their future fertility. STUDY DESIGN: This was a retrospective chart review in a university hospital and a municipal hospital. We injected diluted vasopressin (Pitressin R, total amount of 4-10 units) transvaginally into the cervix surrounding the gestational sac, but not directly into the gestational sac, and/or the lower segment of the uterine body under transvaginal ultrasonographic guidance...
December 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27861141/mir-1-inhibits-progression-of-high-risk-papillomavirus-associated-human-cervical-cancer-by-targeting-g6pd
#11
Tao Hu, Ye-Fei Chang, Zhangang Xiao, Rui Mao, Jun Tong, Bo Chen, Guang-Cai Liu, Ying Hong, Hong-Lan Chen, Shu-Yi Kong, Yan-Mei Huang, Yan-Bin Xiyang, Hua Jin
Ectopic glucose-6-phosphate dehydrogenase (G6PD) expression may contribute to tumorigenesis in cervical cancer associated with high-risk human papillomavirus (HR-HPV 16 and 18) infections. Here, we demonstrate that microRNA-1 (miR-1) in association with AGO proteins targets G6PD in HR-HPV-infected human cervical cancer cells. miR-1 inhibited expression of a reporter construct containing a putative G6PD 3'-UTR seed region and suppressed endogenous G6PD expression. Down-regulation of miR-1 increased G6PD expression in cervical cancer cells...
November 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27829233/mir-142-inhibits-the-development-of-cervical-cancer-by-targeting-hmgb1
#12
Daqiong Jiang, Huiyan Wang, Zhuyan Li, Zhen Li, Xin Chen, Hongbing Cai
It has been reported that miRNAs is deregulated in diverse human cancers, involving human cervical cancer. However, the clinical significances and potential mechanisms of miR-142 in the development and progression of cervical cancer were not elucidated completely till now. In this study, we found that the expression of miR- 142 was obviously down-regulated in human cervical cancer tissues and a panel of cell lines. According to statistics, the expression of miR-142 was negatively related to advanced FIGO stage and lymphatic metastasis (p < 0...
November 5, 2016: Oncotarget
https://www.readbyqxmd.com/read/27819791/-effectiveness-of-a-rapid-response-team-rrt-in-a-case-of-ruptured-ectopic-pregnancy
#13
José Miguel Campechano-López, María Lourdes Carranza-Bernal, Guillermina Juanico-Morales, María Rayo Reyes-Gil
BACKGROUND: An ectopic pregnancy happens when a fertilized egg attaches somewhere outside the endometrial surface. This sort of pregnancy has an estimated incidence of 1.6 to 2 each 100 births. The main objective was to expose the effective answer of a Rapid Response Team in a case of ruptured cervical ectopic pregnancy. We also describe a clinical case of this sort of pregnancy. CLINICAL CASE: 37-year-old female with a two-month history of amenorrhea. The patient entered the Labor & Delivery department with hypovolemic shock secondary to vaginal bleeding...
November 2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27818285/down-regulation-of-microrna-146a-is-associated-with-high-risk-human-papillomavirus-infection-and-epidermal-growth-factor-receptor-overexpression-in-penile-squamous-cell-carcinoma
#14
Elektra Peta, Rocco Cappellesso, Giulia Masi, Alessandro Sinigaglia, Marta Trevisan, Angela Grassi, Barbara Di Camillo, Elisa Vassarotto, Ambrogio Fassina, Giorgio Palù, Luisa Barzon
Dysregulation of host microRNA expression has been involved in the development and progression of human papillomavirus (HPV)-related tumors. Analysis of miR-146a expression in a series of 59 penile squamous cell carcinomas (PSCCs) showed that its levels were lower in high-risk HPV-positive than in HPV-negative PSCCs and inversely correlated with expression of epidermal growth factor receptor (EGFR), a known target for miR-146a. Analysis of genotype distribution for rs2910164, a common functional polymorphism of miR-146a, did not identify correlations with miR-146a levels and EGFR expression in PSCCs...
November 3, 2016: Human Pathology
https://www.readbyqxmd.com/read/27818117/-induced-abortion-guidelines-for-clinical-practice%C3%A2-%C3%A2-text-of-the-guidelines-short-text
#15
C Vayssière, A Gaudineau, L Attali, K Bettahar, S Eyraud, P Faucher, P Fournet, D Hassoun, M Hatchuel, C Jamin, B Letombe, T Linet, M Msika Razon, A Ohanessian, H Segain, S Vigoureux, N Winer, S Wylomanski, A Agostini
OBJECTIVE: Develop recommendations for the practice of induced abortion. MATERIALS AND METHODS: The Pubmed database, the Cochrane Library and the recommendations from the French and foreign Gyn-Obs societies or colleges have been consulted. RESULTS: The number of induced abortions (IA) has been stable for several decades. There are a lot of factors explaining the choice of abortion when there is an unplanned pregnancy (UPP). Early initiation and choice of contraception in connection to the woman's life are associated with lower NSP...
December 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/27803524/cervical-ectopic-pregnancy-a-clinician-s-dilemma
#16
Priyanka H Vora, M J Jassawalla, Sarita Bhalerao, Trupti Nadkarni
No abstract text is available yet for this article.
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27769860/microrna-146a-inhibits-proliferation-migration-and-invasion-of-human-cervical-and-colorectal-cancer-cells
#17
Anusha Sathyanarayanan, Karthik Subramanian Chandrasekaran, Devarajan Karunagaran
microRNAs (miRNAs) play significant roles in diverse biological processes and their deregulation is implicated in carcinogenesis. miR-146a executes tumour suppressive or oncogenic functions depending on the cancer type, but its effect on human cervical (CaCx) and colorectal (CRC) cancers have not been examined thus far. In this study, miR-146a exhibited high expression in CaCx but poor expression in CRC, in comparison to corresponding normal tissues. Nevertheless, ectopic expression of miR-146a inhibited proliferation in both CaCx and CRC cells and curbed their migration and invasion...
October 18, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27769049/mir-424-acts-as-a-tumor-radiosensitizer-by-targeting-aprataxin-in-cervical-cancer
#18
Xia Wang, Qing Li, Hua Jin, Hua Zou, Wei Xia, Nan Dai, Xiao-Yan Dai, Dong Wang, Cheng-Xiong Xu, Yi Qing
Previous studies have shown that some dysregulated miRNAs are involved in radioresistance of tumor cells. Here, we identified significantly decreased miR-424 expression in radioresistant cervical cancer cells and specimens from cervical cancer patients with radioresistance compared to their radiosensitive parental cells and specimens from radiosensitive patients, respectively. Ectopic expression of miR-424 significantly increased radiation-induced DNA damage, cell apoptosis and G2/M cell cycle arrest in radioresistant cervical cancer cells...
October 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27752891/patients-with-cervical-ureaplasma-urealyticum-and-chlamydia-trachomatis-infection-undergoing-ivf-icsi-et-the-need-for-new-paradigm
#19
Qing-Zhen Xie, Wang-Ming Xu, Qian-Rong Qi, Zeng-Li Luo, Lan Dong
Genital tract infections with ureaplasma urealyticum (UU) and chlamydia trachomatis (CT) are the most frequent sexually-transmitted disease worldwide. UU and CT infections are considered to be the leading cause for infertility and adverse pregnancy outcomes. However, little is known about the specific effect of cervical UU and CT infections on the etiology of female infertility, as well as the pregnancy outcomes of the patients undergoing in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET)...
October 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27743413/mir-25-3p-reverses-epithelial-mesenchymal-transition-via-targeting-sema4c-in-cisplatin-resistance-cervical-cancer-cells
#20
Jing Song, Yue Li
Acquisition of epithelial-mesenchymal transition (EMT) has recently been proposed as an important contributor of drug resistance in cervical cancer cells. However, the underlying mechanisms are still unclear. MicroRNAs play a crucial role in regulating EMT. The aim of this study was to explore the potential role of miR-25-3p in regulating EMT in cisplatin-resistant (CR) cervical cancer cells. To this end, we established stable CR cervical cancer cells, HeLa-CR and CaSki-CR, and investigated the function of miR-25-3p in regulating EMT...
October 15, 2016: Cancer Science
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