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https://www.readbyqxmd.com/read/28929066/surgical-treatment-of-retrosternal-goitre
#1
Kiera Welman, Richard Heyes, Paras Dalal, Sarah Hough, Marciano Bunalade, Vladimir Anikin
This study aims to evaluate surgical approaches to the management of retrosternal goitre. Between 2004 and 2014, 35 patients (eight males; mean age 67.4 ± 10.9 years) with retrosternal goitre (mainly right-sided in 9, left-sided in 14 and bilateral in 12) underwent surgery. A palpable neck mass was found in 11 (31.4%), stridor in 10 (28.6%) and thyrotoxicosis in 4 (11.4%) cases. 4 (11.4%) patients were asymptomatic. Tracheal compression was detected radiologically in 27 (77.2%) patients with deviation in 18 (51...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28838077/the-unique-microbiology-and-molecular-pathogenesis-of-mycoplasma-genitalium
#2
REVIEW
Chris L McGowin, Patricia A Totten
Mycoplasma genitalium is increasingly appreciated as a common cause of sexually transmitted disease syndromes, including urethritis in men and cervicitis, endometritis, pelvic inflammatory disease, and possibly preterm birth, tubal factor infertility, and ectopic pregnancy in women. Despite these disease associations, which parallel those of Chlamydia trachomatis and Neisseria gonorrhoeae, the mechanisms by which this pathogen elicits inflammation, causes cellular damage, and persists in its only natural host (humans) are unique and are not fully understood...
July 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28810526/microrna-374c-5p-regulates-the-invasion-and-migration-of-cervical-cancer-by-acting-on-the-foxc1-snail-pathway
#3
Yi Huang, Hao Huang, Mojuan Li, Xiuqing Zhang, Yusong Liu, Yifeng Wang
Some microRNAs (miRNAs) have been implicated in cervical cancer development and progression. However, the roles and mechanisms of several miRNAs in epithelial-mesenchymal transition (EMT) in cervical cancer remain poorly understood. Here, we conducted a microarray analysis and found that miR-374c-5p was most down-regulated miRNA in TGFβ1-treated cervical cancer cells compared to the expression in parental cell lines. Ectopic overexpression of miR-374c-5p inhibited cervical cancerl invasion and migration in TGFβ1- treated cervical cancer cells...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28802022/microrna-492-overexpression-involves-in-cell-proliferation-migration-and-radiotherapy-response-of-cervical-squamous-cell-carcinomas
#4
Mei Liu, Jusheng An, Manni Huang, Liming Wang, Binbin Tu, Yan Song, Kai Ma, Yu Wang, Shuren Wang, Hongxia Zhu, Ningzhi Xu, Lingying Wu
MicroRNAs (miRNAs) are small non-coding RNA that target protein-coding mRNAs at the post-transcriptional level. The aim of this study was to define the role of miR-492 in cervical squamous cell carcinomas. After microRNA profiling and comparison, we firstly detected miR-492 expression in 104 tumor tissues biopsies derived from advanced staged (FIGO IIB-IIIB) cervical squamous cell carcinoma patients before receiving concomitant chemoradiotherapy and found miR-492 expression was significantly higher in the specimens that were sensitive to concomitant chemoradiotherapy, as compared with insensitive cancer specimens (p < 0...
August 12, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28795042/ectopic-cervical-thymoma-a-case-report-and-review
#5
Hyun Oh Park, Sung Hwan Kim, Seong Ho Moon, Jun Ho Yang, Dong Hoon Kang, Jeong Hee Lee
In the embryo, the thymus originates from the third and fourth pharyngeal pouches and migrates from the superior neck to the mediastinum. Ectopic cervical thymoma (ECT) is an extremely rare tumor that originates from ectopic tissue, and is caused by the aberrant migration of the embryonic thymus. Our patient was a 30-year-old woman who had a nodular lesion in the neck for several years. Ultrasonography and computed tomography were performed. She underwent surgery, and a histological examination resulted in a diagnosis of type AB thymoma...
August 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28761619/ectopic-thyroid-tissue-unusual-differential-diagnosis-of-cervical-paraganglioma
#6
Houda Chahed, Ghada Kharrat, Rim Bechraoui, Jihene Marrakchi, Azza Mediouni, Mohamed Ben Amor, Rim Zainine, Nejeh Beltaief, Ghazi Besbes
Ectopic thyroid tissue (ETT) lateral to the midline is rare. Its occurrence in the carotid bifurcation is exceptional. We present a 45 years woman who consulted with a slow growing right cervical swelling. Clinical examination Ultrasonography, contrast enhanced CT and cervical MRI concluded to a paraganglioma. Intra-operatively, the tumor didn't have the characteristic aspect of a paraganglioma. Complete excision was performed. Histology concluded to an ectopic micro-vesicular thyroid adenoma.Previous literature was reviewed to summarize clinical and radiologic characteristics of such rare entity...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28731196/microrna-106a-promotes-cell-migration-and-invasion-by-targeting-tissue-inhibitor-of-matrix-metalloproteinase-2-in-cervical-cancer
#7
Xia Li, Qi Zhou, Ling Tao, Chunxia Yu
Increasing evidence has demonstrated that miRNAs play a critical role in tumor development and progression. Previous studies have revealed that miR-106a is abnormally expressed in various cancers. However, its function and underlying mechanism in cervical cancer (CC) remains unknown. In this study, we confirmed that the expression of miR-106a was significantly upregulated in both CC cell lines and tissues by qRT-PCR. The increased expression of miR-106a was obviously associated with adverse prognostic features...
July 18, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28702266/papillary-thyroid-carcinoma-ectopic-malignancy-versus-metastatic-disease
#8
Yanery's Agosto-Vargas, Madeleine Gutiérrez, José Hernán Martínez, Michelle Mangual-Garcia, Coromoto Palermo, Sharon Vélez-Maymi, Luis Hernández-Vázquez, Samayra Miranda-Rodríguez, Alex González-Bossolo, Ernesto Solá-Sánchez, Marianne Hernández-Negrón
Papillary thyroid carcinoma frequently metastasizes to regional lymph nodes. However, cervical lymph node metastasis as a sole manifestation of occult papillary thyroid carcinoma is rarely observed. Ectopic thyroid is an uncommon condition defined as the presence of thyroid tissue at a site other than pretracheal area. Approximately 1-3% of all ectopic thyroid tissue is located in the lateral neck. This entity may represent the only functional thyroid tissue in the body. Malignant transformation of ectopic thyroid is uncommon; but even rarer is the development of papillary carcinoma on it...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28689684/-ectopic-thymus-a-rare-cause-of-neck-mass-in-children
#9
S Kallel, M Mnejja, M Kessentini, A Ben Said, I Charfeddine, B Hammami, A Ghorbel
INTRODUCTION: Ectopic cervical thymus (ECT) is a rare embryological abnormality in children. It can be revealed by a compressive neck mass mistaken for a malignant tumor. Through a new case of ECT, we review the embryopathogenesis, diagnostic difficulties and therapeutic features. CLINICAL OBSERVATION: A 19-month-old girl presented a right cervical mass that quickly increased in size, causing intermittent dyspnea. The physical examination objectified a 6-cm, soft and compressible, painless right cervical tumefaction, extending from the mastoid area to the ipsilateral supraclavicular fossa...
July 6, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28681918/microrna-137-is-negatively-associated-with-clinical-outcome-and-regulates-tumor-development-through-ezh2-in-cervical-cancer
#10
Huimin Zhang, Ting Yan, Zhijun Liu, Jun Wang, Yu Lu, Donglin Li, Wentong Liang
PURPOSE: We intend to evaluate the expression, clinical relevance and functional role of microRNA-137 (miR-137) in human cervical cancer (CC). METHODS: MiR-137 expressions were assessed by qPCR in CC cell lines and human CC tumors. The correlation between endogenous miR-137 expression and CC Patients' postoperative overall survival was examined statistically. CC cell lines, Ca-Ski and SiHa cells were transduced with lentivirus to ectopically upregulate endogenous miR-137 expressions...
July 6, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28668435/magnetic-resonance-imaging-in-tubal-and-non-tubal-ectopic-pregnancy
#11
REVIEW
Sitthipong Srisajjakul, Patcharin Prapaisilp, Sirikan Bangchokdee
Ectopic pregnancy is the leading cause of pregnancy-related death in the first trimester. Ectopic pregnancy is usually diagnosed by clinical, laboratory, and sonographic findings, with implantation most commonly located in the ampullary part of the fallopian tube. However, pregnancies that develop at unusual implantation sites, such as angular, interstitial, cornual, cervical, ovarian, cesarean scar, and abdominal cavity pregnancies, may rarely occur. Although ultrasound is considered the primary pregnancy-related imaging modality, it may not be able to illustrate the implantation site in certain types of pregnancy...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28651495/mir-205-serves-as-a-prognostic-factor-and-suppresses-proliferation-and-invasion-by-targeting-insulin-like-growth-factor-receptor-1-in-human-cervical-cancer
#12
Hui Pang, Xiuying Yue
MicroRNAs are a kind of small and non-coding RNAs, which have been demonstrated to play an important role in the progression of human cervical cancer. Here, we found that the expression of miR-205 was low in cervical cancer cell lines and tissues, compared with matched non-tumor tissues and human endocervical epithelial cells. Also, miR-205 was inversely correlated with histological differentiation, metastasis, International Federation of Gynecology and Obstetrics stage, and the expression of insulin-like growth factor receptor 1 messenger RNA and protein...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28650075/isl1-controls-patterning-and-mineralization-of-enamel-in-the-continuously-renewing-mouse-incisor
#13
Adrien Naveau, Bin Zhang, Bo Meng, McGarrett T Sutherland, Michaela Prochazkova, Timothy Wen, Pauline Marangoni, Kyle B Jones, Timothy C Cox, Bernhard Ganss, Andrew H Jheon, Ophir D Klein
Rodents are characterized by continuously renewing incisors whose growth is fueled by epithelial and mesenchymal stem cells housed in the proximal compartments of the tooth. The epithelial stem cells reside in structures known as the labial (toward the lip) and lingual (toward the tongue) cervical loops (laCL and liCL, respectively). An important feature of the rodent incisor is that enamel, the outer, highly mineralized layer, is asymmetrically distributed, because it is normally generated by the laCL but not the liCL...
June 26, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28641487/microrna-337-inhibits-cell-proliferation-and-invasion-of-cervical-cancer-through-directly-targeting-specificity-protein-1
#14
Wei Dong, Baosheng Li, Juan Wang, Yipeng Song, Zicheng Zhang, Chengrui Fu
Cervical cancer is the fourth most commonly occurring malignancy in females worldwide. Accumulated studies have demonstrated that the aberrant expression of microRNAs plays important roles in tumorigenesis and tumor development and potentially serves as therapeutic targets in various cancers including cervical cancer. Therefore, the identification of specific microRNAs contributed to cervical cancer formation and progression would provide critical clues for the treatments for patients with this disease. In this study, we aimed to detect microRNA-337 expression pattern and investigate the biological roles of microRNA-337 in the regulation of the malignant phenotypes of cervical cancer and its underlying mechanisms...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28631522/evidence-based-management-of-non-tubal-ectopic-pregnancies
#15
Aderemi Olaoluwa Alalade, Fredrick John Ennis Smith, Charlotte Emma Kendall, Funlayo Odejinmi
Recent advances in ultrasonography and the use of other modalities including magnetic resonance imaging scans have led to the early and more accurate diagnosis of non-tubal ectopic pregnancies (NTE). As a result, the management of these pregnancies has evolved. This article addresses the management options currently available for NTE. While surgical management remains the mainstay of treatment for ovarian, abdominal and cornual ectopics, there is growing evidence that some of these can be managed medically...
November 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28626980/comparison-of-management-regimens-following-ultrasound-diagnosis-of-nontubal-ectopic-pregnancies-a-retrospective-cohort-study
#16
J Ramkrishna, G R Kan, K L Reidy, W C Ang, R Palma-Dias
OBJECTIVE: To review management options for nontubal ectopic pregnancies. DESIGN: Retrospective cohort study. SETTING: Tertiary hospital in Melbourne, Australia. POPULATION: A total of 100 nontubal pregnancies: 1 abdominal, 32 caesarean scar, 14 cervical, 41 cornual-interstitial, 12 ovarian. METHODS: Cases were classified according to ectopic site. Management categories were medical, surgical, combination or expectant...
June 19, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28617891/esophageal-adenocarcinoma-with-enteroblastic-differentiation-arising-in-ectopic-gastric-mucosa-in-the-cervical-esophagus-a-case-report-and-literature-review
#17
Ryosuke Gushima, Rei Narita, Takashi Shono, Hideaki Naoe, Takashi Yao, Yutaka Sasaki
BACKGROUND: Adenocarcinoma with enteroblastic differentiation is a subtype of alpha-fetoprotein (AFP) producing adenocarcinoma. This type of tumor is associated with a poor prognosis and is prone to metastasize. Esophageal adenocarcinoma with enteroblastic differentiation is extremely rare. CASE PRESENTATION: The patient was a 65-year-old woman who was referred to our hospital with dysphagia. Endoscopic examination revealed an elevated lesion 20mm in diameter at 17cm from the upper incisors...
June 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28616412/assessing-the-presence-of-chlamydia-trachomatis-genome-in-pregnant-women-with-spontaneous-abortion-using-polymerase-chain-reaction-method-in-yasuj-first-report-from-southwest-of-iran
#18
Alborz Jahangiri Sisakht, Navid Omidifar, Nahid Mohamadkhani, Maryam Karimpoorfard, Mohammad Kargar, Mansoureh Shokripour
CONTEXT: Chlamydia trachomatis is one of the most prevalent factors of sexually transmitted diseases worldwide, which causes abortion, premature rupture of membrane, uterine cervicitis, pelvic inflammatory diseases, and ectopic pregnancy. AIMS: The aim of this study was to investigate the presence of C. trachomatis genome in pregnant women with abortion in Yasuj, Iran. SETTINGS AND DESIGN: This is a descriptive-analytical study in Shahid Mofateh Gyneco-obstetrics clinic and Emam sajjad Hospital...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28602544/morbidity-of-total-thyroidectomy-for-substernal-goiter-a-series-of-70-patients
#19
N Tabchouri, Z Anil, F Marques, N Michot, P Dumont, V Arnault, L De Calan
Total thyroidectomy for substernal goiter occasionally requires a sternotomy associated with a cervical incision. We sought to analyze the postoperative complications of thyroidectomy for substernal goiters in our center and more precisely the complications related to the sternotomy. All patients who underwent total thyroidectomy for substernal goiter in our center between 2007 and 2016 were reviewed retrospectively. Patients with combined cervical incision and sternotomy (ST group, n=16) were compared to those with cervical incision alone (CT group, n=54), with regard to postoperative complications...
June 8, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/28586112/conservative-management-of-cervical-ectopic-pregnancy-single-center-experience
#20
Semih Zeki Uludag, Mehmet Serdar Kutuk, Ercan Mustafa Aygen, Yılmaz Sahin
AIM: The aim of this study was to assess the results of conservative treatment of cervical ectopic pregnancy (CEP). METHODS: We retrospectively reviewed all cervical ectopic pregnancies diagnosed at the present department between January 2010 and July 2015. Patients with CEP who were treated with either systemic or intra-amniotic methotrexate (MTX) injection were included in the study. RESULTS: Ten CEP patients were identified. Median maternal age was 33 years (range, 23-40 years)...
August 2017: Journal of Obstetrics and Gynaecology Research
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