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https://www.readbyqxmd.com/read/29115998/effect-of-gastric-acid-suppressive-therapy-and-biological-variation-of-serum-gastrin-concentrations-in-dogs-with-chronic-enteropathies
#1
Romy M Heilmann, Nora Berghoff, Niels Grützner, Nolie K Parnell, Jan S Suchodolski, Jörg M Steiner
BACKGROUND: Serum gastrin concentration can help diagnose gastrinomas in dogs if >3-10× the upper reference limit (URL), but antisecretory therapy and other conditions can also cause hypergastrinemia. Effects of antisecretory therapy (famotidine or ranitidine, omeprazole) on serum gastrin concentration in dogs with chronic enteropathy (CE) and its biological variation (BV) are unknown. Aim of the study was to evaluate serum gastrin in acid-suppressant-treated or -naïve CE dogs; test the association between serum gastrin and histopathologic findings in acid-suppressant-naïve CE dogs; and evaluate the BV of serum gastrin in dogs not receiving any gastric acid suppressive therapy...
November 7, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29055278/enhanced-sensitivity-to-detection-nanomolar-level-of-cu-2-compared-to-spectrophotometry-method-by-functionalized-gold-nanoparticles-design-of-sensor-assisted-by-exploiting-first-order-data-with-chemometrics
#2
Zolaikha Rasouli, Raouf Ghavami
A simple, sensitive and efficient colorimetric assay platform for the determination of Cu(2+) was proposed with the aim of developing sensitive detection based on the aggregation of AuNPs in presence of a histamine H2-receptor antagonist (famotidine, FAM) as recognition site. This study is the first to demonstrate that the molar extinction coefficients of the complexes formed by FAM and Cu(2+) are very low (by analyzing the chemometrics methods on the first order data arising from different metal to ligand ratio method), leading to the undesirable sensitivity of FAM-based assays...
October 12, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29038754/histamine-2-receptor-antagonist-famotidine-modulates-cardiac-stem-cell-characteristics-in-hypertensive-heart-disease
#3
Sherin Saheera, Ajay G Potnuri, Renuka Nair
BACKGROUND: Cardiac stem cells (CSCs) play a vital role in cardiac homeostasis. A decrease in the efficiency of cardiac stem cells is speculated in various cardiac abnormalities. The maintenance of a healthy stem cell population is essential for the prevention of adverse cardiac remodeling leading to cardiac failure. Famotidine, a histamine-2 receptor antagonist, is currently used to treat ulcers of the stomach and intestines. In repurposing the use of the drug, reduction of cardiac hypertrophy and improvement in cardiac function of spontaneously hypertensive rats (SHR) was reported by our group...
2017: PeerJ
https://www.readbyqxmd.com/read/28964871/anti-ulcer-and-anti-helicobacter-pylori-potentials-of-the-ethyl-acetate-fraction-of-physalis-alkekengi-l-var-franchetii-solanaceae-in-rodent
#4
Yong Wang, Sui Lou Wang, Jiong Yi Zhang, Xiao Ning Song, Zhi Yong Zhang, Jing Feng Li, Song Li
ETHNOPHARMACOLOGICAL RELEVANCE: Physalis alkekengi L. var. franchetii (Solanaceae) has been widely used in Chinese folk medicine due to its wide distribution throughout the country, for the treatment of a wide range of diseases including heat and cold, sore throat, fever, fungal infection, inflammation, toothache, rheumatism, burn, analgesic, ulcer and urinary diseases. However, the effect of P. alkekengi var. franchetii on ulcer and Helicobacter pylori infection has not been reported to date...
September 28, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28924528/near-fatal-gastrointestinal-hemorrhage-in-a-child-with-medulloblastoma-on-high-dose-dexamethasone
#5
Derek Yecies, Daniel Tawfik, Jennifer Damman, Chad Thorson, David S Hong, Gerald A Grant, Rachel Bensen, Mihaela Damian
A four-year-old female was admitted to a university-based children's hospital with a newly-diagnosed posterior fossa tumor. She was started on famotidine and high-dose dexamethasone and underwent gross total resection of a medulloblastoma. She was continued on dexamethasone and famotidine. She exhibited postoperative posterior fossa syndrome and was started on enteral feeds via the nasoduodenal tube. She had small gastrointestinal bleeds on postoperative days eight, 11, and 18, and was found to have a well-circumscribed posterior duodenal ulcer...
July 7, 2017: Curēus
https://www.readbyqxmd.com/read/28887671/histamine-2-receptor-antagonism-elicits-protection-against-doxorubicin-induced-cardiotoxicity-in-rodent-model
#6
Sundar Kumar Kondru, Ajay Godwin Potnuri, Lingesh Allakonda, Prasad Konduri
Doxorubicin (DOX), an anthracycline-based antibiotic, is regularly used in the management of carcinomas, and haematological malignancies have been downplayed in chemotherapy because of its ability to induce dilated cardiomyopathy (DCM). Dexrazoxane is approved to combat the cardiotoxicity, but limited by its adverse effects. Redox imbalance and reactive oxygen species generation plays major role in DOX-induced cardiotoxicity. Histamine, known to mediate various cardiovascular effects, but nevertheless the role of histamine or its receptors in DOX-induced DCM is remained obscure...
September 8, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28874228/multivariate-validated-models-for-simultaneous-determination-of-ibuprofen-and-famotidine-in-the-presence-of-related-substances
#7
Eman S Elzanfaly, Hala E Zaazaa, Aya T Soudi, Maissa Y Salem
Two multivariate validated spectrophotometric methods, namely partial least-squares (PLS) and principal component regression (PCR), were developed and validated for the determination of ibuprofen and famotidine in presence of famotidine degradation products and ibuprofen impurity (4-isobutylacetophenone). A calibration set was prepared in which the two drugs together with the degradation products and impurity were modeled using a multilevel multifactor design. This calibration set was used to build the PLS and PCR models...
September 6, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28867258/risk-factors-for-suboptimal-drug-concentration-of-posaconazole-oral-suspension-in-patients-with-hematologic-malignancy
#8
E J Kim, K-S Yu, S H Na, E Y Nam, H S Oh, M Kim, S H Yoon, J-O Lee, Y Koh, K-H Song, P G Choe, J-Y Cho, S H Song, E S Kim, H B Kim, S-M Bang, N J Kim, M-D Oh, I Kim, W B Park
Absorption of posaconazole oral suspension is influenced by several factors including diet, medications, and mucosal integrity. However, there are few prospective data about which is the most important modifiable factor in routine clinical practice. We prospectively analyzed clinical risk factors associated with low posaconazole trough concentrations in 114 patients receiving anticancer chemotherapy due to acute myeloid leukemia or myelodysplastic syndrome who received posaconazole oral suspension. In multivariate analyses, risk factors for drug level<500ng/mL included low calorie intake, mucositis≥grade 2, H2 blocker famotidine and proton-pump inhibitor...
August 31, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28834579/topical-flurbiprofen-toxicosis-in-a-cat
#9
Elizabeth M Yi, Elizabeth Leech
OBJECTIVE: To describe the clinical presentation and treatment of a cat with flurbiprofen toxicosis due to topical cream exposure. CASE SUMMARY: A 3-year-old castrated male domestic shorthair cat presented to an emergency and referral center for acute lethargy, hematemesis, and anemia. Severe azotemia was observed on serum biochemistry panel. The patient's anemia was treated with packed RBC transfusion, and treatment with crystalloid fluids, famotidine, pantoprazole, ampicillin, and sucralfate were begun on presentation...
August 23, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28817204/new-insight-into-the-control-of-peptic-ulcer-by-targeting-the-histamine-h2-receptor
#10
Vijai Singh, Nisarg Gohil, Robert Ramírez-García
Peptic ulcer disease is one of the major challenges in public health globally and new evidence shows that it can be controlled by targeting the histamine H2 receptor (H2 R). Recently, a number of H2 R antagonists have been synthesized and used to block the action of histamine on the parietal cells in the stomach and decrease the acid production. In this study, we modeled the H2 R by homology modeling using the 3-D crystal structure and this model was validated based on free energy and amino acid residues present in the allowed regions of a Ramachandran plot...
August 17, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28811943/reviewing-the-emergence-of-lactococcus-garvieae-a-case-of-catheter-associated-urinary-tract-infection-caused-by-lactococcus-garvieae-and-escherichia-coli-coinfection
#11
Tatvam T Choksi, Farhan Dadani
Lactococcus garvieae is considered a low virulence organism which is rarely associated with human infections. Most of the reported cases have been associated with bacteremia with or without endocarditis. We report a rare case of catheter associated urinary tract infection (CAUTI) caused by Lactococcus garvieae and Escherichia coli coinfection without any bacteremia in a patient with indwelling urinary catheter placed for benign prostatic hyperplasia (BPH). The patient also had a history of gastroesophageal reflux disease (GERD) with long standing famotidine treatment...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28801980/effects-of-proton-pump-inhibitors-and-famotidine-on-elimination-of-plasma-methotrexate-evaluation-of-drug-drug-interactions-mediated-by-organic-anion-transporter-3
#12
Katsuya Narumi, Yu Sato, Masaki Kobayashi, Ayako Furugen, Kumiko Kasashi, Takehiro Yamada, Takanori Teshima, Ken Iseki
Methotrexate (MTX) is an antifolate agent used in the treatment of numerous types of cancer, and eliminated by active tubular secretion via organic anion transporter 3 (OAT3). Gastric antisecretory drugs, such as proton pump inhibitors (PPIs) and histamine H2 receptor antagonists, are widely used among patients with cancer in clinical practice. The aim of the present study was to analyze the potential drug-drug interactions between MTX and gastric antisecretory drugs in high-dose MTX (HD-MTX) therapy. We retrospectively analyzed the impact of PPIs on the plasma MTX concentration on 73 cycles of HD-MTX therapy performed in 43 patients...
August 12, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/28776226/a-screen-of-pharmaceutical-drugs-for-their-ability-to-cause-short-term-morbidity-and-mortality-in-the-common-bed-bug-cimex-lectularius-l
#13
Johnathan M Sheele, Gale E Ridge, Wenjing Du, Nikhil Mallipeddi, Mayur Vallabhaneni
The common bed bug, Cimex lectularius L., is a hematophagous ectoparasite that preferentially feeds on humans. Pharmaceuticals present in a person's blood may adversely affect C. lectularius when it feeds. We fed >10,000 C. lectularius on blood samples containing more than 400 different drug doses and drug combinations using an in vitro feeding system to determine insect mortality. The majority of drug doses approximated the peak plasma concentration in humans taking those drugs. Twenty-one drugs were found to cause >17% 12-14-day mortality compared to 8...
October 2017: Parasitology Research
https://www.readbyqxmd.com/read/28738449/pbpk-modeling-of-the-effect-of-reduced-kidney-function-on-the-pharmacokinetics-of-drugs-excreted-renally-by-organic-anion-transporters
#14
C-H Hsueh, V Hsu, P Zhao, L Zhang, K M Giacomini, S-M Huang
Altered pharmacokinetics (PK) in subjects with chronic kidney disease (CKD) may lead to dosing adjustment of certain drugs in subjects with CKD. It can be valuable to quantitatively predict PK in CKD for the management of drug dosing in these subjects. We developed physiologically based pharmacokinetic (PBPK) models of seven renally eliminated drugs: adefovir, avibactam, entecavir, famotidine, ganciclovir, oseltamivir carboxylate, and sitagliptin. These drugs are all substrates of renal organic anion transporters (OATs)...
July 24, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28699491/a-case-of-pantoprazole-anaphylaxis-with-cross-reactivity-to-all-proton-pump-inhibitors-finding-a-safe-alternative
#15
Özlem Türedi, Zeynep Çelebi Sözener, Reşat Kendirlinan, Sevim Bavbek
BACKGROUND: Hypersensitivity reactions due to Proton pump inhibitors (PPIs ) are rare, and further anaphylaxis to a PPI with cross-reactivity to all commercially available PPIs is very rare Objective: To present a case of anaphylaxis to pantoprazole with cross-reactivity to all commercially available PPIs Method: Skin prick tests (SPTs), intradermal tests (IDTs) and oral provocation tests (OPTs) were performed with available PPIs according to the method described in previous studies. RESULTS: All tested PPIs except lansoprazole were positive on skin tests either SPT or IDT...
July 11, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/28690192/suppression-of-osteogenic-differentiation-in-mesenchymal-stem-cells-from-patients-with-ossification-of-the-posterior-longitudinal-ligament-by-a-histamine-2-receptor-antagonist
#16
Xizhe Liu, Gentaro Kumagai, Kanichiro Wada, Toshihiro Tanaka, Taku Fujita, Ayako Sasaki, Ken-Ichi Furukawa, Yasuyuki Ishibashi
Mesenchymal stem cells (MSCs) in ossification of the posterior longitudinal ligament (OPLL) patients have a high propensity toward osteogenesis. Histamine receptor H2 (H2R) antagonists (H2 blockers) like famotidine decrease ossification in patients, by an unclear mechanism. To confirm that MSCs express H2R and to clarify how H2 blockers suppress osteogenic differentiation, we used spinal-ligament MSCs from patients with OPLL or with cervical spondylotic myelopathy (CSM) (control). The MSCs were treated with 10, 30, or 100nM famotidine for 7 or 21 days...
September 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28625018/no-pharmacokinetic-interaction-between-the-hepatitis-c-virus-inhibitors-elbasvir-grazoprevir-and-famotidine-or-pantoprazole
#17
H-P Feng, P Vaddady, Z Guo, F Liu, D Panebianco, V Levine, L Caro, J R Butterton, M Iwamoto, W W Yeh
Use of agents to suppress gastric acid secretion is common among patients with hepatitis C virus (HCV) infection. The aims of this open-label, three-period, fixed-sequence study were to evaluate the effect of famotidine and pantoprazole on the pharmacokinetics and safety of elbasvir/grazoprevir fixed-dose combination (FDC) in 16 healthy subjects. Elbasvir and grazoprevir each exhibited similar pharmacokinetics following single-dose administration of elbasvir/grazoprevir with or without famotidine or pantoprazole...
September 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28618071/histamine-receptor-2-modifies-inkt-cell-activity-within-the-inflamed-lung
#18
R Ferstl, R Frei, W Barcik, E Schiavi, K Wanke, M Ziegler, N Rodriguez-Perez, D Groeger, P Konieczna, S Zeiter, D Nehrbass, R Lauener, C A Akdis, L O'Mahony
BACKGROUND: Histamine is a key immunoregulatory mediator and can dampen proinflammatory responses via activation of histamine receptor 2 (H2 R). The aim of this study was to determine the role of H2 R in modulating lung inflammatory responses. METHODS: H2 R was blocked using famotidine or activated using dimaprit in both the ovalbumin (OVA) and house dust mite extract (HDM) murine models of respiratory inflammation. H2 R-deficient animals and CD1d/H2 R-deficient animals were utilized to examine the CD1d presentation of lipid antigens (αGalCer or OCH) to invariant natural killer T (iNKT) cells...
June 15, 2017: Allergy
https://www.readbyqxmd.com/read/28605740/a-randomized-double-blind-pilot-study-of-the-effect-of-famotidine-on-acotiamide-treatment-for-functional-dyspepsia
#19
Mariko Hojo, Akihito Nagahara, Daisuke Asaoka, Tsutomu Takeda, Kentaro Izumi, Kohei Matsumoto, Hiroya Ueyama, Yuji Shimada, Kenshi Matsumoto, Shuko Nojiri, Sumio Watanabe
BACKGROUND/AIMS: Acotiamide, a prokinetic drug, is used to treat functional dyspepsia (FD), especially postprandial distress syndrome (PDS). However, a treatment for FD patients with PDS and/or epigastric pain syndrome (EPS) has not been established. We investigated the efficacy of famotidine in combination with acotiamide for FD. METHODS: Fifty blindly randomized FD patients received placebo with acotiamide, or famotidine with acotiamide, for 4 weeks. Treatment efficacy was assessed by overall treatment effects (OTE), total, PDS and EPS symptom scores, and impairment of quality of life (QOL)...
2017: Digestion
https://www.readbyqxmd.com/read/28580333/oral-administration-of-vitamin-c-cimetidine-and-famotidine-on-micronuclei-induced-by-low-dose-radiation-in-mouse-bone-marrow-cells
#20
A Naeeji, H Mozdarani, A Shabestani Monfared, F Faeghi, A A Ahmadi, M Gholami, R Behzadi, M R Momtaz
BACKGROUND: In many studies, chemicals and natural materials were tested to reduce the harmful effects of radiation. It is known that Famotidine and vitamin C reduce DNA damage. OBJECTIVE: The aim of this study was to evaluate the radioprotective effect of vitamin C, Cimetidine and Famotidine on gamma-radiation-induced damage on mouse bone marrow. METHODS: Six-to-seven week male NMRI mice (28 g ±3) were randomly divided into fourteen groups: control, 2Gy irradiation, six group drugs without irradition (Famotidine, Cimetidine, vitaminC, Fam-Cim, Fam-Vit, Cim-Vit), six groups received drugs and 2Gy radiation with a 60Co |γ|-ray source at room temperature 22 ± 2 °C...
June 2017: Journal of Biomedical Physics & Engineering
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