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https://www.readbyqxmd.com/read/29780141/hemorrhagic-stress-induced-gastric-ulcer-in-a-healthy-toddler
#1
Katsunori Matsueda, Tatsuya Toyokawa, Masahiro Sakata, Isao Fujita, Jouichiro Horii, Yoshiko Abe, Toru Araki
A 1-year-old female toddler who was under a great amount of psychological stress presented with acute hematemesis. She had no significant medical history; she displayed lethargy and was anemic. Although blood transfusion and famotidine were administered for upper gastrointestinal bleeding (UGIB), the anemia did not improve. Thus, early endoscopy was performed under general anesthesia, revealing a gastric ulcer with exposed vessels in the supra-angular region. Cauterization via bipolar hemostatic forceps was performed on the exposed vessels, and the bleeding was controlled successfully...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29657733/contrast-medium-induced-transient-severe-leukopenia
#2
Takashi Hongo, Satoshi Nozaki, Midori Tsuchiya, Mototaka Inaba, Kenji Takahashi, Toshifumi Fujiwara
Case: Contrast medium-induced transient leukopenia is very rare. Here, we report a case of a 73-year-old man diagnosed with contrast media-induced transient leukopenia. The patient underwent abdominal contrast-enhanced computed tomography, where he was given non-ionic iodinated contrast medium i.v. His medical history included an allergic reaction to a different contrast medium. One hour later, the patient was admitted to the emergency department complaining of chest discomfort. He had leukopenia and a fever (temperature of 38...
April 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29609611/association-between-industry-payments-and-prescribing-costly-medications-an-observational-study-using-open-payments-and-medicare-part-d-data
#3
Manvi Sharma, Aisha Vadhariya, Michael L Johnson, Zachary A Marcum, Holly M Holmes
BACKGROUND: While many new medications may offer advantages over existing drugs, some newer drugs are reformulations of existing products that provide little innovation or incremental benefit while driving up drug costs. Despite the lack of benefit of these medications, prescribers may be motivated by payments made by the pharmaceutical industry. The objective of the study was to determine the association between payments made to physicians by the pharmaceutical industry and prescriptions for certain selected costly brand name drugs...
April 2, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29593173/-evaluation-of-dissolution-profiles-of-famotidine-from-over-the-counter-drugs
#4
Yuji Saito, Naoki Adachi, Miki Kato, Masayuki Nadai
  In recent years, self-medication has started to receive more attention in Japan owing to increasing medical costs and health awareness among people. One of the main roles of pharmacists in self-medication is to provide appropriate information regarding over-the-counter (OTC) drugs. However, pharmacists promoting the proper use of OTC drugs have little information on their formulation properties. In this study, we performed dissolution tests on both OTC drugs and ethical drug (ED) containing famotidine, and evaluated the differences in their dissolution profiles...
March 27, 2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29572958/pharmacokinetics-and-efficacy-of-intravenous-famotidine-in-adult-cattle
#5
Christie C Balcomb, Meera C Heller, Munashe Chigerwe, Heather K Knych, Allison M Meyer
BACKGROUND: Abomasal ulceration is recognized in neonatal and adult cattle, but research regarding treatment is limited. Histamine-2 receptor antagonists (H2 RA), such as famotidine, are used clinically with little evidence-based research about efficacy in adult cattle. HYPOTHESIS AND OBJECTIVES: Intravenous famotidine administered at 0.4 mg/kg will increase the pH of abomasal outflow digesta compared to saline control in adult cattle. The objectives were to assess the effect of famotidine, administered as a single dose and as multiple doses, on abomasal outflow fluid pH in adult cattle...
March 23, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29564944/tablet-formulation-of-famotidine-loaded-p-gp-inhibiting-nanoparticles-using-pla-g-peg-grafted-polymer
#6
Mohamed Mokhtar, Patrick M Gosselin, Lacasse François-Xavier, Patrice Hildgen
Our work aimed at evaluating the use of Permeability glycoprotein (P-gp) inhibiting nanoparticles (NPs) as a part of a suitable oral solid dosage to improve bioavailability. Famotidine (Pepcid®), a stomach acid production inhibitor, was used as a drug model to test our hypothesis. Famotidine-loaded NPs were prepared by solvent emulsion evaporation using PEG grafted on a polylactide acid (PLA) polymer backbone (PLA-g-PEG), with a 5% molar ratio of PEG vs lactic acid monomer and PEG of either 750 or 2000 Da molecular weight...
March 22, 2018: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29557529/clinical-pharmacokinetics-and-drug-drug-interactions-of-elbasvir-grazoprevir
#7
Tony K L Kiang
Elbasvir and grazoprevir, in a fixed-dose combination of 50 and 100 mg, respectively, have received approval to be administered orally once daily, with or without ribavirin, for the treatment of chronic hepatitis C virus (HCV) infections. The absorption characteristics of elbasvir and grazoprevir have been adequately summarized, although differences were observed for grazoprevir (e.g., increased exposure at steady state in patients), but not elbasvir, between healthy and HCV-infected subjects. Inconsistencies with respect to absorption were also reported on the effects of food or acid reducers (famotidine or pantoprazole) in the literature...
March 20, 2018: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29522172/does-common-prescription-medication-affect-the-rate-of-orthodontic-tooth-movement-a-systematic-review
#8
Militiadis A Makrygiannakis, Eleftherios G Kaklamanos, Athanasios E Athanasiou
Background: As the taking of any medication may theoretically affect the complex pathways responsible for periodontal tissue homeostasis and the events leading to orthodontic tooth movement, it is considered important for the orthodontist to be able to identify prospective patients' history and patterns of pharmaceutical consumption. Objective: To systematically investigate and appraise the quality of the available evidence regarding the effect of commonly prescribed medications on the rate of orthodontic tooth movement...
March 6, 2018: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29513129/in-vivo-anti-ulcerogenic-effect-of-okra-abelmoschus-esculentus-on-ethanol-induced-acute-gastric-mucosal-lesions
#9
Deniz Ortaç, Mustafa Cemek, Turan Karaca, Mehmet E Büyükokuroğlu, Zafer Ö Özdemir, Ayşe Tuba Kocaman, Sadık Göneş
CONTEXT: Okra, Abelmoschus esculentus (L.) (Malvaceae), is a medicinal plant widely used in Turkish traditional medicine for the treatment of various diseases such as ulcers and gastritis. OBJECTIVE: In the present study, we evaluated the gastroprotective effect of okra against ethanol-induced acute gastric mucosal injury in animal models. MATERIALS AND METHODS: Wistar rats were treated with 500, 250 or 100 mg/kg okra; 20 mg/kg famotidine (Fam); and 75 mg/kg quercetin (Que)...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29493162/-clinical-therapy-of-zisheng-decoction-recipe-for-chronic-atrophic-gastritis-with-intestinal-metaplasia
#10
Xiu-Xia Wu, Xian Li, Zhong-Qin Dang, Wen-Zhao Luo, Chang-Pu Zhao, Kun Yu
To explore the therapeutic effect and security of Zisheng decoction recipein treatment of the chronic atrophic gastritis (CAG) with intestinal metaplasia(IM). A total of 147 eligible cases were randomly divided into the traditional Chinese medicine group, Western medicine group and the combined group,47 cases in each group. Zisheng decoction recipe, famotidine, as well as Zisheng decoction recipe + famotidine were respectively given in the above three groups, with a treatment course of 30 d. The symptoms of traditional Chinese medicine, pathological score of gastric mucosa and the negative rate of Helicobacter pylori before and after treatment were observed in each group...
December 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29477541/surface-modification-and-evaluation-of-bacterial-cellulose-for-drug-delivery
#11
Munair Badshah, Hanif Ullah, Abdur Rahman Khan, Shaukat Khan, Joong Kon Park, Taous Khan
The current study was designed to prepare surface modified BC matrices loaded with model drugs selected on the basis of their aqueous solubility, i.e., poorly water soluble famotidine and highly water soluble tizanidine. Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA) confirmed the successful drug loading and thermal stability of the BC matrices. In-vitro dissolution studies using USP type-II dissolution apparatus showed that most of the drug was released in 0...
July 1, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29455270/ventricular-tachycardia-triggered-by-loperamide-and-famotidine-abuse
#12
Timothy R Larsen, Jedediah McMunn, Hala Ahmad, Soufian T AlMahameed
A 32-year-old male developed recurrent ventricular tachycardia after taking mega doses of loperamide and famotidine in order to experience an opiate-like euphoric effect. He was taking up to 200 mg of loperamide and multiple doses of famotidine each day. He developed palpitations and syncope. Electrocardiography demonstrated ventricular tachycardia and QT interval prolongation (corrected QT interval was 597 ms). He was diagnosed with loperamide-induced QT prolongation resulting in incessant ventricular tachycardia...
February 17, 2018: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29426514/application-of-polyacrylonitrile-nanofibers-decorated-with-magnetic-carbon-dots-as-a-resonance-light-scattering-sensor-to-determine-famotidine
#13
Somayeh Maleki, Tayyebeh Madrakian, Abbas Afkhami
In this study, a novel resonance light scattering (RLS) sensor was synthesized using polyacrylonitrile nanofibers decorated with magnetic carbon dots (MCDs@NFs) nanocomposite and applied for famotidine (FMD) determination. The MCDs@NFs nanocomposite was synthesized by combining electrospinning and a simple one-step hydrothermal method. Different methods were applied in order to characterize the MCDs@NFs nanocomposite such as: scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), Transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD)...
May 1, 2018: Talanta
https://www.readbyqxmd.com/read/29397336/artesunate-affords-protection-against-aspirin-induced-gastric-injury-by-targeting-oxidative-stress-and-proinflammatory-signaling
#14
Sneh Verma, Vijay L Kumar
BACKGROUND: Prolonged use of aspirin, a commonly prescribed non steroidal anti-inflammatory drug, is well known to produce gastrointestinal toxicity which could be minimized by various anti-secretory agents. The present study was carried out to evaluate the protective effect of artesunate against aspirin induced gastric injury in rats. METHODS: Gastric injury was induced in fasted Wistar rats by oral administration of aspirin. The effect of 50 and 150mg/kg of artesunate was studied on macroscopic changes, gastric secretions, histology, oxidative stress and inflammatory markers in the stomach tissue after 5h of induction of gastric injury...
April 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29378195/inhibition-of-hepatic-apolipoprotein-a-i-gene-expression-by-histamine
#15
Michael J Haas, Monica Plazarte, Ayham Chamseddin, Luisa Onstead-Haas, Norman C W Wong, Gabriela Plazarte, Arshag D Mooradian
In a recent high throughput analysis to identify drugs that alter hepatic apolipoprotein A-I (apo A-I) expression, histamine receptor one (H1 ) antagonists emerged as potential apo A-1 inducing drugs. Thus the present study was undertaken to identify some of the underlying molecular mechanisms of the effect of antihistaminic drugs on apo AI production. Apo A-I levels were measured by enzyme immunoassay and Western blots. Apo A-I mRNA levels were measured by reverse transcription real-time PCR using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA as the internal control...
March 15, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29360138/interventions-to-reduce-acute-and-late-adverse-gastrointestinal-effects-of-pelvic-radiotherapy-for-primary-pelvic-cancers
#16
REVIEW
Theresa A Lawrie, John T Green, Mark Beresford, Linda Wedlake, Sorrel Burden, Susan E Davidson, Simon Lal, Caroline C Henson, H Jervoise N Andreyev
BACKGROUND: An increasing number of people survive cancer but a significant proportion have gastrointestinal side effects as a result of radiotherapy (RT), which impairs their quality of life (QoL). OBJECTIVES: To determine which prophylactic interventions reduce the incidence, severity or both of adverse gastrointestinal effects among adults receiving radiotherapy to treat primary pelvic cancers. SEARCH METHODS: We conducted searches of CENTRAL, MEDLINE, and Embase in September 2016 and updated them on 2 November 2017...
January 23, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29303081/a-new-approach-to-enhance-the-solubility-of-famotidine-tablet-by-using-naturally-isolated-pear-starch
#17
Anjali Kushwaha, Manjul Pratap Singh
PURPOSE- The solubility of drug is affected by various excipients presents in formulation. In case of tablets the role of binders is very important for solubility of dosage form as well as drug. Thus in following study an attempt is made to improve the solubility and dissolution rate of a drug by use of natural excipients. The starch was extracted from the Pear fruits and used as a binder in different concentrations, in famotidine tablets and evaluate them. There are some recent patents on modified starch (WO2011002730A1), directly compressed starch (US6455069B1), pre-compacted starches (US4072535A), which helped in my study...
January 4, 2018: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29280084/the-effect-of-nesfatin-1-on-food-intake-in-neonatal-chicks-role-of-crf-1-crf2-and-h1-h3-receptors
#18
Hooman Heidarzadeh, Morteza Zendehdel, Vahab Babapour, Hasan Gilanpour
The present study was designed to determine the effect of central injection of Nesfatin-1 and corticotropin and histaminergic systems on food intake in neonatal meat-type chicks. In this study, 7 experiments were designed, each with 4 treatment groups. In experiment 1, four groups of chicks received the ICV injection of (A) phosphate-buffered saline (PBS), (B) Nesfatin-1 (10 ng), (C) Nesfatin-1 (20 ng) and (D) Nesfatin-1 (40 ng). In experiment 2, (A) PBS, (B) Astressin-B (CRF1 /CRF2 receptors antagonist; 30 µg), (C) Nesfatin-1 (40 ng) and (D) Nesfatin-1 + Astressin-B were injected...
March 2018: Veterinary Research Communications
https://www.readbyqxmd.com/read/29200812/application-of-micellar-extraction-for-isolation-of-famotidine-from-aqueous-samples-prior-to-its-chromatographic-determination
#19
Ilona Kiszkiel-Taudul, Barbara Starczewska, Joanna Karpińska, Monika Kasabuła
Micellar extraction was applied to isolate famotidine from aqueous samples. This drug is an H2 receptor antagonist used for the treatment of stomach diseases. The process was performed with a mixture of anionic sodium dodecylsulfate and nonionic Triton X-114 surfactants. The effect of different parameters on the efficiency of the micellar extraction such as electrolyte and surfactant concentration, pH of sample, temperature, shaking and centrifugation time was investigated. The influence of foreign substances on a studied process was tested...
2017: Journal of Surfactants and Detergents
https://www.readbyqxmd.com/read/29115998/effect-of-gastric-acid-suppressive-therapy-and-biological-variation-of-serum-gastrin-concentrations-in-dogs-with-chronic-enteropathies
#20
Romy M Heilmann, Nora Berghoff, Niels Grützner, Nolie K Parnell, Jan S Suchodolski, Jörg M Steiner
BACKGROUND: Serum gastrin concentration can help diagnose gastrinomas in dogs if >3-10× the upper reference limit (URL), but antisecretory therapy and other conditions can also cause hypergastrinemia. Effects of antisecretory therapy (famotidine or ranitidine, omeprazole) on serum gastrin concentration in dogs with chronic enteropathy (CE) and its biological variation (BV) are unknown. Aim of the study was to evaluate serum gastrin in acid-suppressant-treated or -naïve CE dogs; test the association between serum gastrin and histopathologic findings in acid-suppressant-naïve CE dogs; and evaluate the BV of serum gastrin in dogs not receiving any gastric acid suppressive therapy...
November 7, 2017: BMC Veterinary Research
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