keyword
https://read.qxmd.com/read/38457485/extracorporeal-membrane-oxygenation-after-liver-transplant-in-children-a-review-of-the-elso-registry
#21
JOURNAL ARTICLE
Matteo Di Nardo, Vladimir L Cousin, Danilo Alunni-Fegatelli, Serge Grazioli, Peter Rycus, Ravi R Thiagarajan, Raphael Joye, Angelo Polito
There are minimal data describing use of extracorporeal membrane oxygenation (ECMO) in pediatric patient after a liver transplantation (LT). This study aimed at describing ECMO run in this specific situation using the data from Extracorporeal Life Support Organization (ELSO) Registry between January 1, 2010, to December 31, 2022. We described patients' characteristics at ECMO initiation, outcome and mortality risk factors. We identified 27 patients with a median age of 2.7 years (interquartile range (IQR) = 1...
March 7, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/38456999/respiratory-extracorporeal-membrane-oxygenation-from-rescue-therapy-to-standard-tool-for-treatment-of-acute-respiratory-distress-syndrome
#22
REVIEW
Richard Greendyk, Rahul Kanade, Madhavi Parekh, Darryl Abrams, Philippe Lemaitre, Cara Agerstrand
BACKGROUND: The use of extracorporeal membrane oxygenation (ECMO) for patients with acute respiratory distress syndrome (ARDS) has increased substantially. With modern trials supporting its efficacy, ECMO has become an important tool in the management of severe ARDS. OBJECTIVES: The objectives of this paper are to discuss ECMO physiology and configurations used for patients with ARDS, review evidence supporting the use of ECMO for ARDS, and discuss aspects of management during ECMO...
March 8, 2024: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://read.qxmd.com/read/38449055/pulmonary-shunt-in-critical-care-a-practical-approach-with-clinical-scenarios
#23
REVIEW
Davide Raimondi Cominesi, Mario Forcione, Matteo Pozzi, Marco Giani, Giuseppe Foti, Emanuele Rezoagli, Francesco Cipulli
BACKGROUND: Pulmonary shunt refers to the passage of venous blood into the arterial blood system bypassing the alveoli-blood gas exchange. Pulmonary shunt is defined by a drop in the physiologic coupling of lung ventilation and lung perfusion. This may consequently lead to respiratory failure. MAIN BODY: The pulmonary shunt assessment is often neglected. From a mathematical point of view, pulmonary shunt can be assessed by estimating the degree of mixing between oxygenated and deoxygenated blood...
March 6, 2024: J Anesth Analg Crit Care
https://read.qxmd.com/read/38448059/protocol-for-venoarterial-extracorporeal-membrane-oxygenation-to-reduce-morbidity-and-mortality-following-bilateral-lung-transplantation-the-ecmotop-randomised-controlled-trial
#24
JOURNAL ARTICLE
Jonathan Messika, Philippine Eloy, David Boulate, Aude Charvet, Julien Fessler, Jacques Jougon, Philippe Lacoste, Olaf Mercier, Philippe Portran, Hadrien Roze, Edouard Sage, Jacques Thes, Francois Tronc, Mickael Vourc'h, Philippe Montravers, Yves Castier, Herve Mal, Pierre Mordant
INTRODUCTION: Lung transplantation (LTx) aims at improving survival and quality of life for patients with end-stage lung diseases. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is used as intraoperative support for LTx, despite no precise guidelines for its initiation. We aim to evaluate two strategies of VA-ECMO initiation in the perioperative period in patients with obstructive or restrictive lung disease requiring bilateral LTx. In the control 'on-demand' arm, high haemodynamic and respiratory needs will dictate VA-ECMO initiation; in the experimental 'systematic' arm, VA-ECMO will be pre-emptively initiated...
March 5, 2024: BMJ Open
https://read.qxmd.com/read/38446867/dissolved-oxygen-relevantly-contributes-to-systemic-oxygenation-during-venovenous-extracorporeal-membrane-oxygenation-support
#25
JOURNAL ARTICLE
Michael C Müller, Sarah K Wilke, Andrej Dobbermann, Sascha Kirsten, Martin Ruß, Steffen Weber-Carstens, Tobias Wollersheim
When determining extracorporeal oxygen transfer (VMLO2) during venovenous extracorporeal membrane oxygenation (VV ECMO) dissolved oxygen is often considered to play a subordinate role due to its poor solubility in blood plasma. This study was designed to assess the impact of dissolved oxygen on systemic oxygenation in patients with acute respiratory distress syndrome (ARDS) on VV ECMO support by differentiating between dissolved and hemoglobin-bound extracorporeal oxygen transfer. We calculated both extracorporeal oxygen transfer based on blood gas analysis using the measuring energy expenditure in extracorporeal lung support patients (MEEP) protocol and measured oxygen uptake by the native lung with indirect calorimetry...
March 5, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/38446842/percutaneous-venopulmonary-extracorporeal-membrane-oxygenation-as-bridge-to-lung-transplantation
#26
JOURNAL ARTICLE
Asad Ali Usman, Audrey Elizabeth Spelde, Wasim Lutfi, Jacob T Gutsche, William J Vernick, Omar Toubat, Salim E Olia, Edward Cantu, Andrew Courtright, Maria M Crespo, Joshua Diamond, Mauer Biscotti, Christian A Bermudez
Mechanical circulatory support (MCS) as a bridge to lung transplant is an infrequent but accepted pathway in patients who have refractory end-stage pulmonary failure. The American Association of Thoracic Surgeons Expert Consensus Guidelines, published in 2023, recommends venovenous (VV) extracorporeal membrane oxygenation (ECMO) as the initial configuration for those patients who have failed conventional medical therapy, including mechanical ventilation, while waiting for lung transplantation and needing MCS...
March 6, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/38446827/does-size-matter-the-effect-of-size-of-distal-perfusion-catheter-on-acute-limb-ischemia-a-meta-analysis
#27
JOURNAL ARTICLE
Doug A Gouchoe, Sameer Chaurasia, Matthew C Henn, Bryan A Whitson, Nahush A Mokadam, David Mast, Sree Satyapriya, Ajay Vallakati, Asvin M Ganapathi
Prevention of limb ischemia in patients with venoarterial extracorporeal membrane oxygenation (VA-ECMO) is primarily achieved through the use of distal perfusion catheters (DPC). Our objective was to assess the role of DPC, and specifically the size of the catheter, in reducing the incidence of acute limb ischemia (ALI) through a meta-analysis. Seventeen studies met criteria for analysis. Pooled analysis included a total of 2,040 patients, of which 904 patients received ECMO with DPC and 1,136 patients underwent ECMO without DPC...
March 5, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/38443964/neonatal-persistent-pulmonary-hypertension-related-to-a-novel-tbx4-mutation-case-report-and-review-of-the-literature
#28
REVIEW
Chiara Maddaloni, Sara Ronci, Domenico Umberto De Rose, Iliana Bersani, Francesca Campi, Matteo Di Nardo, Francesca Stoppa, Rachele Adorisio, Antonio Amodeo, Alessandra Toscano, Maria Cristina Digilio, Antonio Novelli, Giovanni Chello, Annabella Braguglia, Andrea Dotta, Flaminia Calzolari
TBX4 gene, located on human chromosome 17q23.2, encodes for T-Box Transcription Factor 4, a transcription factor that belongs to the T-box gene family and it is involved in the regulation of some embryonic developmental processes, with a significant impact on respiratory and skeletal illnesses. Herein, we present the case of a female neonate with persistent pulmonary hypertension (PH) who underwent extracorporeal membrane oxygenation (ECMO) on the first day of life and then resulted to have a novel variant of the TBX4 gene identified by Next-Generation Sequencing...
March 5, 2024: Italian Journal of Pediatrics
https://read.qxmd.com/read/38442924/-annual-review-of-clinical-research-on-extracorporeal-life-support-in-2023
#29
JOURNAL ARTICLE
Hongling Zhang, Yuan Yu, Dechang Chen, You Shang
The clinical research in the field of extracorporeal life support (ECLS) in 2023 has focused on the efficacy of veno-arterial extracorporeal membrane oxygenation (ECMO) in patients with infarct-related cardiogenic shock. Additionally, the research also explored the efficacy of prone positioning during veno-venous ECMO, transfusion strategies, and the impact of obesity on outcomes. Awake veno-venous ECMO has shown novel therapeutic potential, but its optimal practice methods and management strategies remain to be determined...
February 2024: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/38442737/nosocomial-infections-in-adults-receiving-extracorporeal-membrane-oxygenation-a-review-for-infectious-diseases-clinicians
#30
JOURNAL ARTICLE
Joseph E Marcus, Aditya Shah, Giles J Peek, Graeme MacLaren
Over the past ten years, there has been a rapid expansion in the use of extracorporeal membrane oxygenation (ECMO) in the care of patients with refractory cardiac or respiratory failure. Infectious diseases clinicians must reconcile conflicting evidence from limited studies as they develop practices at their own institutions, which has resulted in considerably different practices globally. This review describes infection control and prevention as well as antimicrobial prophylaxis strategies in this population...
March 5, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38435953/a-comprehensive-review-of-extra-corporeal-membrane-oxygenation-the-lifeline-in-critical-moments
#31
REVIEW
Sindhu Geetha, Neeta Verma, Vivek Chakole
Extracorporeal membrane oxygenation (ECMO) has evolved into a pivotal intervention in critical care, offering a lifeline for patients facing severe respiratory or cardiac failure. This review provides a comprehensive exploration of ECMO, spanning its definition and historical background to its contemporary advancements and ongoing impact in critical care. The versatility of ECMO in addressing diverse critical conditions, careful patient selection criteria, and the nuanced management of complications are discussed...
January 2024: Curēus
https://read.qxmd.com/read/38432196/neonatal-extracorporeal-membrane-oxygenation-associations-between-continuous-renal-replacement-therapy-thrombocytopenia-and-outcomes
#32
JOURNAL ARTICLE
Lauren R Walker, Laura E Hollinger, W Michael Southgate, David T Selewski, Jeffrey E Korte, Mathew Gregoski, Heidi J Steflik
INTRODUCTION: The incidence of thrombocytopenia in neonates receiving extracorporeal membrane oxygenation (ECMO) with and without concurrent continuous renal replacement therapy (CRRT) and associated complications have not been well described. The primary aims of the current study were to (1) characterize thrombocytopenia in neonates receiving ECMO (including treated concurrently with CRRT) and (2) evaluate risk factors (including CRRT utilization) associated with severe thrombocytopenia...
March 1, 2024: Blood Purification
https://read.qxmd.com/read/38429791/impact-of-hyperoxia-on-the-gut-during-critical-illnesses
#33
REVIEW
Ninan Dai, Juan Gu, Yanhong Luo, Yuanfa Tao, Yuehting Chou, Ying He, Han Qin, Tao Chen, Xiaoyun Fu, Miao Chen, Zhouxiong Xing
Molecular oxygen is typically delivered to patients via oxygen inhalation or extracorporeal membrane oxygenation (ECMO), potentially resulting in systemic hyperoxia from liberal oxygen inhalation or localized hyperoxia in the lower body from peripheral venoarterial (VA) ECMO. Consequently, this exposes the gastrointestinal tract to excessive oxygen levels. Hyperoxia can trigger organ damage due to the overproduction of reactive oxygen species and is associated with increased mortality. The gut and gut microbiome play pivotal roles in critical illnesses and even small variations in oxygen levels can have a dramatic influence on the physiology and ecology of gut microbes...
March 1, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38428755/vasoplegic-syndrome-during-heart-transplantation-a-systematic-review-and-meta-analysis
#34
JOURNAL ARTICLE
Nicolas Kumar, Michael G Fitzsimons, Manoj H Iyer, Michael Essandoh, Julia E Kumar, Adam A Dalia, Asishana Osho, Tamara R Sawyer, Amit Bardia
BACKGROUND: Vasoplegic syndrome (VS) is a common occurrence during heart transplantation (HT). It currently lacks a uniform definition between transplant centers, and its pathophysiology and treatment remain enigmatic. This systematic review summarizes the available published clinical data regarding VS during HT. METHODS: We searched databases for all published reports on VS during HT. Data collected included the incidence of VS in the HT population, patient and intraoperative characteristics, and postoperative outcomes...
February 28, 2024: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/38421440/venoarterial-extracorporeal-membrane-oxygenation-implementation-in-septic-shock-rat-model
#35
JOURNAL ARTICLE
Tianlong Wang, Mingru Zhang, Wenhao Dong, Jing Wang, Han Zhang, Yuefu Wang, Bingyang Ji
Septic shock, a global health concern, boasts high mortality rates. Research exploring the efficacy of venoarterial extracorporeal membrane oxygenation (VA-ECMO) in septic shock remains limited. Our study aimed to establish a rodent model employing VA-ECMO in septic shock rats, assessing the therapeutic impact of VA-ECMO on septic shock. Nineteen Sprague-Dawley rats were randomly assigned to sham, septic shock, and (septic shock + VA-ECMO; SSE) groups. Septic shock was induced by intravenous lipopolysaccharides, confirmed by a mean arterial pressure drop to 25-30% of baseline...
February 20, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/38420563/racial-disparities-among-patients-on-venovenous-extracorporeal-membrane-oxygenation-in-the-pre-coronavirus-disease-2019-and-coronavirus-disease-2019-eras-a-retrospective-registry-review
#36
JOURNAL ARTICLE
Zachary Obinna Enumah, Eric W Etchill, Bo Soo Kim, Katherine A Giuliano, Andrew Kalra, Sung-Min Cho, Glenn J R Whitman, Jinny S Ha, Chun Woo Choi, Robert S D Higgins, Errol L Bush
OBJECTIVES: Although many studies have addressed such disparities caused by COVID-19, to our knowledge, no study has focused on the association of race on outcomes for patients with COVID-19 requiring venovenous extracorporeal membrane oxygenation support. The goal of this study was to assess association of race on death and duration on venovenous extracorporeal membrane oxygenation in both the pre-COVID-19 and COVID-19 eras. METHODS: We retrospectively reviewed the Extracorporeal Life Support Organization registry and included adults (≥18 years) who required venovenous extracorporeal membrane oxygenation between January 2019 and April 2021...
February 2024: JTCVS open
https://read.qxmd.com/read/38417432/clinical-effects-of-nitric-oxide-added-to-the-oxygenator-of-children-on-extracorporeal-membrane-oxygenation-pre-post-cohort-study
#37
JOURNAL ARTICLE
Kevin C Pan, Siva P Namachivayam, Roberto Chiletti, Derek Best, Stephen Horton, Warwick Butt
Nitric oxide (NO) can be safely delivered through the sweep gas to the oxygenator of an extracorporeal membrane oxygenation (ECMO) circuit. It has theoretical benefits such as preventing platelet adhesion to surfaces, mitigating inflammatory response and protection against ischemia-reperfusion injury. In this uncontrolled before-after study of children on ECMO, the outcomes of those who received NO were compared with those who did not. Among 393 ECMO runs (from 337 patients), 192 of 393 (49%) received NO and 201 of 393 (51%) did not...
February 29, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/38411671/late-onset-progressive-sensorineural-hearing-loss-in-the-paediatric-population-a-systematic-review
#38
REVIEW
Virginia Corazzi, Surina Fordington, Tamsin Holland Brown, Neil Donnelly, Jessica Bewick, Diana Ehsani, Stefano Pelucchi, Chiara Bianchini, Andrea Ciorba, Daniele Borsetto
PURPOSE: To review possible risk factors for permanent delayed-onset, progressive sensorineural hearing loss (SNHL) in the paediatric population to recommend follow-up protocols for early detection. METHODS: PRISMA-compliant systematic review was performed, including observational studies on the paediatric population up to 16 years old who have passed the newborn hearing screening programme (NHSP), investigating the development of late-onset, progressive SNHL...
February 27, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38410596/a-risk-score-for-predicting-extracorporeal-membrane-oxygenation-support-before-lung-transplantation
#39
JOURNAL ARTICLE
Yaoliang Zhang, Juan Li, Wenjie Xie, Chao Yang, Guilin Peng, Xin Xu, Lan Lan
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) has been increasingly used as life support for lung transplantation. However, there are no clinical risk models to predict whether ECMO support is required for lung transplantation. This study developed a simple risk score to predict the need for intraoperative ECMO in patients undergoing lung transplantation, identify high-risk patients who need ECMO support, and guide clinical interventions. METHODS: Patients, who underwent lung transplantation between January 1, 2016 and July 31, 2021, were systematically reviewed...
January 30, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38410544/visual-analysis-of-the-research-literature-on-extracorporeal-membrane-oxygenation-assisted-support-for-respiratory-failure-based-on-citespace-and-vosviewer-a-20-year-study
#40
JOURNAL ARTICLE
Wei Wang, Bin Xiong, Shulin Xiang, Jianyu Ji, Jing Pang, Lin Han
BACKGROUND: This study aims to visually assess the bibliometric status, current hotspots, and development trends in the field of extracorporeal membrane oxygenation (ECMO)-assisted support for respiratory failure through an examination of articles pertaining to ECMO-assisted support for respiratory failure. METHODS: A search was conducted on pertinent literature in the domain of ECMO-assisted support for respiratory failure published from 2003 to 2023, utilizing the Web of Science Core Collection (WOSCC) database...
January 30, 2024: Journal of Thoracic Disease
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