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IVF Blastocyst Transfer

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https://www.readbyqxmd.com/read/29648640/should-extended-blastocyst-culture-include-day-7
#1
Elizabeth R Hammond, Lynsey M Cree, Dean E Morbeck
Extended culture to the blastocyst stage is widely practised, improving embryo selection and promoting single embryo transfer. Selection of useable blastocysts typically occurs on Days 5 and 6 of embryo culture. Embryos not suitable for transfer, biopsy or cryopreservation after Day 6 are routinely discarded. Some embryos develop at a slower rate, however, forming blastocysts on Day 7 of culture. Day 7 blastocysts can be viable, they can be of top morphological grade, euploid and result in a healthy live birth...
April 10, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29616311/serum-levels-of-pentraxin-3-differ-significantly-at-the-time-of-blastocyst-transfer-depending-on-implantation-success-a-pilot-study
#2
Alexander Freis, Kyra Von Horn, Tamara Göggl, Stephanie Hecht, Sabine Roesner, Thomas Strowitzki, Ariane Germeyer
OBJECTIVE: Many approaches try to identify the underlying molecular mechanisms to detect new potential biomarkers for successful artificial reproductive therapies. One factor has been described as a possible regulator of inflammation during implantation: Pentraxin 3 (PTX3), which seems to be essential for female fertility on one hand, but whose overexpression has been described in many obstetric complications based on abnormal placentation on the other hand. Therefore, we investigated if serum levels of PTX3 at the time of embryo transfer differ between women with an ongoing pregnancy compared to those without implantation...
April 3, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29605408/cumulus-oophorus-complexes-favor-physiologic-selection-of-spermatozoa-for-intracytoplasmic-sperm-injection
#3
Caizhu Wang, Guixue Feng, Jinhui Shu, Hong Zhou, Bo Zhang, Huanhua Chen, Ruoyun Lin, Xianyou Gan, Zhulian Wu, Tinglv Wei
OBJECTIVE: To investigate the effectiveness of cumulus oophorus complexes (COCs) in the physiologic selection of spermatozoa for intracytoplasmic sperm injection (ICSI). DESIGN: A prospective sibling oocytes study. SETTING: Center of reproductive medicine. PATIENT(S): Couples undergoing ICSI during 2016, females aged ≤38 years, and at least six metaphase II (MII) oocytes retrieved. Sixty patients were included in the study...
March 28, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29574310/high-serum-igf-1-levels-are-associated-with-pregnancy-loss-following-frozen-thawed-euploid-embryo-transfer-cycles
#4
Mohamad Irani, Dimitrios Nasioudis, Steven S Witkin, Vinay Gunnala, Steven D Spandorfer
An elevated level of insulin growth factor (IGF-1) in rat uterine fluid has been shown to exert detrimental effects of embryo development possibly leading to an increase in pregnancy loss. Interestingly, the administration of somatostatin to rats undergoing superovulation reduced IGF-1 levels in uterine luminal fluid and thus reversed its deleterious effects on embryo development and increased the number of normal embryos. Therefore, we investigated whether serum levels of IGF-1 correlate with the incidence of pregnancy loss following IVF...
March 16, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29564832/time-lapse-imaging-for-the-detection-of-chromosomal-abnormalities-in-primate-preimplantation-embryos
#5
Brittany L Daughtry, Shawn L Chavez
The use of time-lapse microscopic imaging has proven to be a powerful tool for the study of mitotic divisions and other cellular processes across diverse species and cell types. Although time-lapse monitoring (TLM) of human preimplantation development was first introduced to the in vitro fertilization (IVF) community several decades ago, it was not until relatively recently that TLM systems were commercialized for clinical embryology purposes. Traditionally, human IVF embryos are assessed by successful progression and morphology under a stereomicroscope at distinct time points prior to selection for transfer...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29551013/the-interval-transfer-of-a-frozen-thawed-embryo-is-more-successful-than-a-fresh-embryo-transfer-for-women-undergoing-ivf-with-recurrent-implantation-failure-after-cleavage-stage-embryo-biopsy
#6
Jennifer C Pontré, John P Ryan, Andy Tan, Roger J Hart
BACKGROUND: Recurrent implantation failure (RIF) is repeated unsuccessful embryo transfers (ETs). AIMS: To identify predictive embryonic markers of implantation in RIF, following pre-implantation genetic screening (PGS) of cleavage stage embryos, after accounting for male and female factors. MATERIALS AND METHODS: Retrospective analysis of RIF patients undergoing PGS after correction of modifiable causes. RESULTS: Eighty-four patients underwent 140 in vitro ferilisation cycles...
March 18, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29546361/single-embryo-transfer-by-day-3-time-lapse-selection-versus-day-5-conventional-morphological-selection-a-randomized-open-label-non-inferiority-trial
#7
Lanlin Yang, Sufen Cai, Shuoping Zhang, Xiangyi Kong, Yifan Gu, Changfu Lu, Jing Dai, Fei Gong, Guangxiu Lu, Ge Lin
STUDY QUESTION: Does single cleavage-stage (Day 3) embryo transfer using a time-lapse (TL) hierarchical classification model achieve comparable ongoing pregnancy rates (OPR) to single blastocyst (Day 5) transfer by conventional morphological (CM) selection? SUMMARY ANSWER: Day 3 single embryo transfer (SET) with a hierarchical classification model had a significantly lower OPR compared with Day 5 SET with CM selection. WHAT IS KNOWN ALREADY: Cleavage-stage SET is an alternative to blastocyst SET...
March 13, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29546326/a-rationale-for-biopsying-embryos-reaching-the-morula-stage-on-day-6-in-women-undergoing-preimplantation-genetic-testing-for-aneuploidy
#8
M Irani, N Zaninovic, C Canon, C O'Neill, V Gunnala, Q Zhan, G Palermo, D Reichman, Z Rosenwaks
STUDY QUESTION: Is there a benefit to assessing ploidy in delayed embryos reaching the morula stage on Day 6 of development? SUMMARY ANSWER: Day-6 morulae should be considered for biopsy in women <40 years old undergoing preimplantation genetic testing for aneuploidy (PGT-A) because they are associated with acceptable, albeit reduced, euploidy and implantation rates (IRs). WHAT IS KNOWN ALREADY: Embryo development and morphology have been shown to correlate with aneuploidy and pregnancy rates...
March 13, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29545772/a-proof-of-concept-clinical-trial-of-a-single-luteal-use-of-long-acting-gonadotropin-releasing-hormone-antagonist-degarelix-in-controlled-ovarian-stimulation-for-in-vitro-fertilization-long-antagonist-protocol
#9
Evangelos G Papanikolaou, Hakan Yarali, Evi Timotheou, Michael Grynberg, Odysseas Zafeiratis, Herman Tournaye, Robert Najdecki
Introduction: A drawback of gonadotropin-releasing hormone (GnRH) antagonist protocols in in vitro fertilization (IVF) is that they have limited flexibility in cycle programming. This proof of concept study explored the efficacy of a single-dose, long-acting GnRH antagonist IVF protocol. Trial registration number is NCT03240159, retrospectively registered on March 08, 2017. Materials and methods: The efficacy of a single-dose long-acting antagonist, degarelix, was explored initially in healthy donors and subsequently in infertile patients...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29544364/should-all-embryos-be-cultured-to-blastocyst-for-advanced-maternal-age-women-with-low-ovarian-reserve-a-single-center-retrospective-study
#10
Panyu Chen, Tingting Li, Lei Jia, Cong Fang, Xiaoyan Liang
The purpose of this study is to determine whether all-blastocyst-culture can benefit advanced maternal age (AMA) patients with low ovarian reserve. We retrospectively analyze AMA patients with low ovarian reserve undergoing IVF/ICSI in Reproductive Medicine Research Center of the Sixth Affiliated Hospital of Sun Yat-sen University from May 2016 to August 2017. We divide them into group A (all-blastocyst-culture) and group B (none-blastocystculture) based on different culture approach of D3 transferrable embryo...
March 16, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29538675/determinants-of-monozygotic-twinning-in-art-a-systematic-review-and-a-meta-analysis
#11
Kathrine Vauvert R Hviid, Sara Sofia Malchau, Anja Pinborg, Henriette Svarre Nielsen
BACKGROUND: The incidence of monozygotic twins (MZT) after ART appears to be higher than the incidence after spontaneous conceptions contradicting the aim of ART to avoid multiple pregnancies because of the associated risks. OBJECTIVE AND RATIONALE: The aim was to study the frequency of MZT after IVF and ICSI and how it is influenced by the day of embryo transfer, maternal age, zona pellucida manipulation, controlled ovarian stimulation, stimulation protocol, culture media and embryo quality...
March 12, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29530836/the-effect-of-intramural-fibroids-without-an-intra-cavity-component-on-in-vitro-fertilization-outcomes-in-single-fresh-blastocyst-transfer-cycles
#12
Sadikah Behbehani, Stefano Polesello, Joseph Hasson, Justin Silver, Weon-Young Son, Michael Dahan
OBJECTIVE: Asses clinical pregnancy rates and live birth rates in the presence of non-cavity deforming intramural fibroids in single fresh blastocyst transfer cycles DESIGN CLASSIFICATION: Canadian Task Force classification II-2 SETTING SETTING: Academic fertility center. PATIENT(S): 929 fresh single blastocyst transfer cycles were included; 94 with only non cavity distorting intramural fibroids and 764 without fibroids. Cleavage embryo transfers were excluded to reduce bias based on embryo quality INTERVENTION(S): none MAIN OUTCOME MEASURE(S): Live birth rate (LBR) and clinical pregnancy rate (CPR) RESULT(S): There were no differences noted in gravity, parity, or body mass index in patients with and without fibroids...
March 9, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29510635/-various-approaches-of-endometrial-preparation-for-frozen-thawed-embryo-transfer
#13
J Vodička, M Dvořan, K Smékalová, L Michnová, P Hejtmánek, K Lehnertová, J Dostál, M Pešková, M Annenková, R Pilka
OBJECTIVE: Various approaches of endometrial preparation for frozen-thawed embryo transfer. DESIGN: Retrospective analysis. SETTING: Department of Obstetric and Gyneacology, Faculty of Medicine, Palacky University, University Hospital Olomouc. METHODS: Effectivity of frozen-thawed embryo transfers was carried out between January and August 2017 in the IVF unit at the University Hospital Olomouc. Results were compared among groups A, B, C with various approaches of endometrial preparation...
2018: Ceská Gynekologie
https://www.readbyqxmd.com/read/29508122/embryonal-mitochondrial-dna-relationship-to-embryo-quality-and-transfer-outcomes
#14
Amber M Klimczak, Lucia E Pacheco, Kelsey E Lewis, Niloofar Massahi, Jon P Richards, William G Kearns, Antonio F Saad, John R Crochet
PURPOSE: The aim was to study the association between embryonal mitochondrial DNA (mtDNA) content and embryo quality and implantation outcomes. METHODS: A retrospective chart review was performed with data collected from a private IVF center database. The study population included female infertility patients with ages ranging from 31 to 38 years old, and the main outcome measures were embryo quality and transfer outcomes. RESULTS: From a total of 1510 blastocyst biopsies, the majority of embryos consisted of grade 1 (High), followed by grade 2 (mid), and grade 3 (poor)...
March 5, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29499098/the-impact-of-histones-linked-to-sperm-chromatin-on-embryo-development-and-art-outcome
#15
C Fournier, E Labrune, J Lornage, G Soignon, S Giscard d'Estaing, J-F Guérin, M Benchaib
The purpose of this study was to investigate the relationship between the proportion of sperm chromatin linked to remaining histone and assisted reproductive technology (ART) outcome. A prospective cohort study was performed on couples undergoing ART process at the Department of Reproduction Medicine (HFME, Bron, France). The histone-to-protamine ratio (HPR) was measured using the method described by Wykes & Krawetz (2003) J Biol Chem 278, 29471. The correlations with sperm DFI, blastocyst formation, pregnancy rate, and delivery rate were investigated...
March 2, 2018: Andrology
https://www.readbyqxmd.com/read/29480852/combined-analysis-of-endometrial-thickness-and-pattern-in-predicting-clinical-outcomes-of-frozen-embryo-transfer-cycles-with-morphological-good-quality-blastocyst-a-retrospective-cohort-study
#16
Wei Yang, Tao Zhang, Zhou Li, Xinling Ren, Bo Huang, Guijin Zhu, Lei Jin
To evaluate the combined effect of endometrial thickness and pattern on clinical outcomes in females following in vitro fertilization/intracytoplasmic sperm injection and frozen-thawed embryo transfer (IVF/ICSI-FET).FET cycles using at least 1 morphological good-quality blastocyst conducted between 2012 and 2013 at a university-based reproductive center were reviewed retrospectively. Endometrial ultrasonographic characteristics were recorded on the day of progesterone supplementation in FET cycles. In the combined analysis, endometrial thickness groups (group 1: equal or < 8 mm; group 2: >8 mm) were subdivided into 2 endometrial patterns (pattern A: triple-line; pattern B: no-triple line)...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29458903/day-4-good-morula-embryo-transfer-provided-compatible-live-birth-rate-with-day-5-blastocyst-embryo-in-fresh-ivf-et-cycles
#17
Ryh-Sheng Li, Yuh-Ming Hwu, Robert Kuo-Kuang Lee, Sheng-Hsiang Li, Ming-Huei Lin
OBJECTIVE: Embryo transfers during cleavage stage (day 2 or day 3) and blastocyst stages (day 5 or day 6) are common in current daily practice in fresh IVF/ET cycles. Data regarding transferring day 4 embryos, morula/compact stage, is still restricted and the grading system is also inconsistent, as between IVF clinics. This study provided a new detailed classification system for morula/compact stage embryos and compared successes rates between day 4 and day 5 ET. MATERIALS AND METHODS: This was a retrospective study...
February 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29453221/h3k9-demethylase-kdm4e-is-an-epigenetic-regulator-for-bovine-embryonic-development-and-a-defective-factor-for-nuclear-reprogramming
#18
Xin Liu, Yizhi Wang, Yuanpeng Gao, Jianmin Su, Jingcheng Zhang, Xupeng Xing, Chuan Zhou, Kezhen Yao, Quanli An, Yong Zhang
Aberrant epigenetic reprogramming often results in developmental defects in somatic cell nuclear transfer (SCNT) embryos during embryonic genome activation (EGA). Bovine eight-cell SCNT embryos exhibit global hypermethylation of histone H3 lysine 9 tri- and di-methylation (H3K9me3/2), but the intrinsic reason for this remains elusive. Here, we provide evidence that two H3K9 demethylase genes, lysine-specific demethylase 4D ( KDM4D ) and 4E ( KDM4E ), are related to active H3K9me3/2 demethylation in in vitro fertilized (IVF) embryos and are deficiently expressed in cloned embryos at the time of EGA...
February 16, 2018: Development
https://www.readbyqxmd.com/read/29447173/dynamic-changes-of-setd2-a-histone-h3k36-methyltransferase-in-porcine-oocytes-ivf-and-scnt-embryos
#19
Yun Fei Diao, Tao Lin, Xiaoxia Li, Reza K Oqani, Jae Eun Lee, So Yeon Kim, Dong Il Jin
SETD2 (SET domain containing protein 2) acts as a histone H3 lysine 36 (H3K36)-specific methyltransferase and may play important roles in active gene transcription in human cells. However, its expression and role in porcine oocytes and preimplantation embryos are not well understood. Here, we used immunofluorescence and laser scanning confocal microscopy to examine SETD2 expression in porcine fetal fibroblasts, oocytes, and preimplantation embryos derived from in vitro fertilization (IVF), parthenogenetic activation (PA), and somatic cell nuclear transfer (SCNT)...
2018: PloS One
https://www.readbyqxmd.com/read/29436143/infertility-treatment-strategy-involving-combined-freeze-all-embryos-and-single-vitrified-warmed-embryo-transfer-during-hormonal-replacement-cycle-for-in-vitro-fertilization-of-women-with-hypogonadotropic-hypogonadism
#20
Keiji Kuroda, Kenji Ezoe, Keiichi Kato, Akiko Yabuuchi, Tomoya Segawa, Tamotsu Kobayashi, Asako Ochiai, Noriko Katoh, Satoru Takeda
AIM: Hypogonadotropic hypogonadism (HH) is a condition caused by the deficient secretion of pituitary gonadotropins, leading to diminished ovarian function. Several studies of in vitro fertilization (IVF) in women with HH revealed acceptable clinical pregnancy outcomes but high multiple pregnancy rates after multiple fresh embryo transfer (ET). The purpose of this study was to analyze the outcomes of combined freeze-all embryos and single vitrified-warmed ET in women with HH. METHODS: Of 91 infertile women with HH (basal luteinizing hormone and follicle-stimulating hormone levels <2...
February 13, 2018: Journal of Obstetrics and Gynaecology Research
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