keyword
https://read.qxmd.com/read/38544653/implications-of-human-chorionic-gonadotropin-hcg-therapy-in-a-varicocele-patient-and-its-effect-on-in-vitro-fertilization-ivf-outcome
#1
Shradha M Ulhe, Dipali More, Mayur Wanjari
This case study pertains to a 32-year-old male and a 29-year-old female who sought treatment at a fertility clinic due to their primary infertility, which had persisted for over four years. Both individuals underwent comprehensive physical and hormonal examinations; while all reports for the female partner indicated normal findings, the test reports for the male partner revealed the presence of azoospermia and varicocele. The standard surgical protocol for varicocelectomy was followed. However, no improvement in the semen parameters was observed...
February 2024: Curēus
https://read.qxmd.com/read/38537318/effects-of-donor-age-and-reproductive-history-on-developmental-potential-of-ovum-pickup-oocytes-in-japanese-black-cattle-wagyu
#2
JOURNAL ARTICLE
Yinyan Du, Yuhan Xia, Jiahui Xu, Zhihui Liu, Zhentian Liu, Meijie Zhang, Guangyong Xu, Xuesong Xing, Fuliang Du
The objectives of this study were to analyze the (1) effects of donor age and multiparity on development of in vitro fertilization (IVF) embryos after ovum pickup (OPU), (2) effects of repeated and consecutive OPU-IVF procedures on embryo development, and (3) embryo production from OPU-IVF in donors with differing embryo yields after multiple ovulation and embryo transfer technology (MOET) in Japanese Black cattle (Wagyu). Donors were pre-treated with low-dosage follicle-stimulating hormone (FSH; 200 IU total), and oocytes were collected via OPU and fertilized by IVF to generate blastocysts...
March 22, 2024: Theriogenology
https://read.qxmd.com/read/38532894/developmental-potential-of-non-and-mono-pronuclear-zygotes-and-associated-clinical-outcomes-in-ivf-cycles
#3
JOURNAL ARTICLE
Mengyi Zhu, Qiyin Dong, Yurong Zhu, Yun Le, Tengfei Wang, Yuanping Zhou, Sheng Yang
PURPOSE: This study aims to evaluate the developmental potential of 0PN, 1PN, and 2PN zygotes in IVF cycles and compare their clinical outcomes. METHODS: We conducted a retrospective cohort study involving IVF patients. Blastocyst formation rates were assessed with 0PN, 1PN, and 2PN zygotes. Subsequently, we collected clinical outcome data following the transfer of these zygotes. RESULTS: The overall blastulation rate was similar between 0PN (29...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38527601/embryo-long-term-storage-does-not-affect-art-outcome-analysis-of-58001-vitrified-blastocysts-over-an-11-year-period
#4
JOURNAL ARTICLE
Ana Cobo, Aila Coello, María J DE Los Santos, Jose Remohi, Jose Bellver
BACKGROUND: Recently the potential detrimental effect that the duration of storage time may have on vitrified samples has raised some concern, especially when some studies found an association between cryo-storage length and decreased clinical results. OBJECTIVE: This study aimed to evaluate the effects of the storage time length of day-5 vitrified blastocysts in two study groups: freeze-all cycles and non elective frozen embryo transfers (FET). STUDY DESIGN: This was a retrospective study including 58001 vitrified/warmed day-5 blastocysts from two different populations according to the reason for FET...
March 23, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38525303/arginine-with-leucine-drives-reactive-oxygen-species-mediated-integrin-%C3%AE-5%C3%AE-1-expression-and-promotes-implantation-in-mouse-blastocysts
#5
JOURNAL ARTICLE
Momoka Nakazato, Mumuka Matsuzaki, Daiki Okai, Eisaku Takeuchi, Misato Seki, Miki Takeuchi, Emiko Fukui, Hiromichi Matsumoto
The implantation rate of in vitro fertilization (IVF)-derived blastocysts after embryo transfer remains low, suggesting that the inadequate expression of specific proteins in culture-induced IVF-derived blastocysts contributes to low implantation rates. Therefore, treatment with appropriate regulation may improve the blastocyst implantation ability. This study demonstrated that the combination of l-arginine (Arg) and l-leucine (Leu) exerts distinct effects on IVF-derived mouse blastocysts. Arg with Leu promotes blastocyst implantation, whereas Arg alone decreases the blastocyst ability...
March 2024: PNAS Nexus
https://read.qxmd.com/read/38524208/oocyte-cryopreservation-and-reciprocal-in%C3%A2-vitro-fertilization-in-a-transgender-man-on-long-term-testosterone-gender-affirming-hormone-therapy-a-case-report
#6
JOURNAL ARTICLE
Justin White, Aaron Jackson, Irena Druce, Jenna Gale
OBJECTIVE: To report a successful case of oocyte cryopreservation and subsequent in vitro fertilization (IVF) in a transgender male receiving continued testosterone gender-affirming hormone therapy, followed by reciprocal embryo transfer (ET). DESIGN: A case report of a rare case of fertility preservation in a transgender man with concomitant use of testosterone therapy for 4 years before and during ovarian stimulation. SETTING: Private fertility clinic with university affiliation...
March 2024: F&S reports
https://read.qxmd.com/read/38524206/comparing-reproductive-outcomes-between-conventional-in%C3%A2-vitro-fertilization-and-nonindicated-intracytoplasmic-sperm-injection-in-autologous-embryo-transfer-cycles-a-society-for-assisted-reproductive-technology-clinic-outcome-reporting-system-study
#7
JOURNAL ARTICLE
Julian A Gingold, Haotian Wu, Harry Lieman, Manvinder Singh, Sangita Jindal
OBJECTIVE: To compare clinical outcomes between nonindicated intracytoplasmic sperm injection (ICSI) and conventional insemination. DESIGN: Autologous cycles performed from 2014-2017 were identified, excluding frozen oocyte cycles. Outcomes were compared between conventional insemination (in vitro fertilization [IVF]) and nonindiated ICSI and analyzed separately for fresh, frozen-thawed preimplantation genetic testing (PGT) and frozen-thawed non-PGT cycles. SETTING: US-based fertility clinics reporting to the Society for Assisted Reproductive Technology...
March 2024: F&S reports
https://read.qxmd.com/read/38524204/does-embryo-biopsy-independent-of-vitrification-impact-perinatal-outcomes-an-analysis-of-perinatal-outcomes-following-preimplantation-genetic-testing-biopsy-in-fresh-and-frozen-embryo-transfer-cycles
#8
JOURNAL ARTICLE
Kristin Van Heertum, Elizabeth A DeVilbiss, James Goldfarb, Sunni L Mumford, Rachel Weinerman
OBJECTIVE: To compare neonatal outcomes in pregnancies resulting from embryos that have undergone preimplantation genetic testing (PGT) biopsy compared with no biopsy in both fresh and frozen embryo transfers (ETs) and determine whether findings are mediated by multiple births. DESIGN: Retrospective cohort study. SETTING: Society of Assisted Reproductive Technologies-Clinical Outcomes Reporting System data, 2014-2015. PATIENTS: Autologous in vitro fertilization treatment cycles using fresh or frozen blastocyst ET, with or without PGT biopsy...
March 2024: F&S reports
https://read.qxmd.com/read/38519105/interleukin-6-supplementation-improves-bovine-conceptus-elongation-and-transcriptomic-indicators-of-developmental-competence
#9
JOURNAL ARTICLE
Savannah L Speckhart, Mary A Oliver, Jessica A Keane, Nicholas W Dias, Vitor R G Mercadante, Fernando H Biase, Alan D Ealy
A high incidence of pregnancy failures occurs in cattle during the second week of pregnancy as blastocysts transition into an elongated conceptus. This work explored whether interleukin-6 (IL6) supplementation during in vitro embryo production would improve subsequent conceptus development. Bovine embryos were treated with 0 or 100 ng/mL recombinant bovine IL6 beginning on day 5 post-fertilization. At day 7.5 post-fertilization, blastocysts were transferred into estrus synchronized beef cows (n = 5 recipients/treatment, 10 embryos/recipient)...
March 22, 2024: Biology of Reproduction
https://read.qxmd.com/read/38515829/blastocyst-telomere-length-predicts-successful-implantation-after-frozen-thawed-embryo-transfer
#10
JOURNAL ARTICLE
Chun-Wei Chien, Yen-An Tang, Shuen-Lin Jeng, Hsien-An Pan, H Sunny Sun
STUDY QUESTION: Do embryos with longer telomere length (TL) at the blastocyst stage have a higher capacity to survive after frozen-thawed embryo transfer (FET)? SUMMARY ANSWER: Digitally estimated TL using low-pass whole genome sequencing (WGS) data from the preimplantation genetic testing for aneuploidy (PGT-A) process demonstrates that blastocyst TL is the most essential factor associated with likelihood of implantation. WHAT IS KNOWN ALREADY: The lifetime TL is established in the early cleavage cycles following fertilization through a recombination-based lengthening mechanism and starts erosion beyond the blastocyst stage...
2024: Human Reproduction Open
https://read.qxmd.com/read/38499932/human-metaphase-ii-oocytes-with-narrow-perivitelline-space-have-poor-fertilization-developmental-and-pregnancy-potentials
#11
JOURNAL ARTICLE
Masashi Shioya, Miki Okabe-Kinoshita, Tatsuya Kobayashi, Maki Fujita, Keiichi Takahashi
PURPOSE: To analyze the fertilization, developmental, and pregnancy potentials in oocytes with narrow perivitelline space. METHODS: Perivitelline space (PVS) of oocytes was evaluated at the time of ICSI, and those without sufficient PVS were judged as oocytes with narrow PVS (NPVS oocytes), and those with sufficient PVS formation were judged as oocytes with non-narrow PVS (non-NPVS oocytes). The analysis included 634 NPVS oocytes from 278 cycles and 12,121 non-NPVS oocytes from 1698 cycles...
March 19, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38497547/technology-for-biobanking-of-epididymal-spermatozoa-from-patient-with-obstructive-azoospermia-case-report-about-baby-born-after-conventional-freezing-only-with-a-nonpermeable-cryoprotectant-360-kda-polyvinylpyrrolidone
#12
JOURNAL ARTICLE
Maryna Petrushko, Taisiia Yurchuk, Volodymyr Piniaiev, Evgenia Isachenko, Gohar Rahimi, Peter Mallmann, Volodimir Isachenko
This publication reports, for the first time, the birth of a healthy child after intracytoplasmic sperm injection (ICSI) of motile spermatozoa after conventional ("slow") freezing of epididymal spermatozoa using 5% polyvinylpyrrolidone (PVP) of high molecular weight (360 kDa). Cryopreservation solution with 10% PVP was added to 30 µL of spermatozoa suspension in a 1:1 ratio, with a final PVP concentration of 5%. Then, polycarbonate capillaries for oocyte denudation with a diameter of 170 µm were filled with 60 µL of the resulting sperm suspension...
March 18, 2024: Biopreservation and Biobanking
https://read.qxmd.com/read/38488008/single-cell-sequencing-shows-mosaic-aneuploidy-in-most-human-embryos
#13
JOURNAL ARTICLE
Sarah A Robertson, Robert I Richards
Mammalian preimplantation embryos often contain chromosomal defects that arose in the first divisions after fertilization and affect a subpopulation of cells - an event known as mosaic aneuploidy. In this issue of the JCI, Chavli et al. report single-cell genomic sequencing data for rigorous evaluation of the incidence and degree of mosaic aneuploidy in healthy human in vitro fertilization (IVF) embryos. Remarkably, mosaic aneuploidy occurred in at least 80% of human blastocyst-stage embryos, with often less than 20% of cells showing defects...
March 15, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38482566/elagolix-represents-a-less-invasive-and-cheaper-option-than-injectable-gnrh-antagonist-for-ovulation-suppression-in-ivf
#14
JOURNAL ARTICLE
Marco Mouanness, Zaher Merhi
BACKGROUND: The injectable GnRH antagonists have traditionally been used for ovulation suppression during controlled ovarian hyperstimulation in IVF, leading to increased painful daily injections and cost. The use of the oral GnRH antagonist elagolix for ovulation suppression in IVF has not been studied. METHODS: A retrospective cohort study of patients undergoing IVF received either oral elagolix 50 mg every other day or ganirelix/cetrotide injection daily for ovulation suppression during controlled ovarian hyperstimulation...
March 14, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38482262/preimplantation-genetic-testing-within-the-public-healthcare-system-in-slovenia
#15
JOURNAL ARTICLE
M Volk, K Writzl, A Veble, H Jaklič, N Teran, B Prosenc, M Štimpfel, I Virant Klun, E Vrtačnik Bokal, H Ban Frangež, B Peterlin
Preimplantation genetic testing (PGT) is the earliest form of prenatal diagnosis that has become an established procedure for couples at risk of passing a severe genetic disease to their offspring. At UMC Ljubljana, we conducted a retrospective register-based study to present 15 years of PGT service within the public healthcare system in Slovenia. We collected the data of the PGT cycles from 2004 to 2019 and compared clinical outcomes for chromosomal and monogenic diseases using different embryo biopsy and testing approaches...
December 2023: Balkan Journal of Medical Genetics: BJMG
https://read.qxmd.com/read/38474081/when-the-embryo-meets-the-endometrium-identifying-the-features-required-for-successful-embryo-implantation
#16
REVIEW
Valentina Lacconi, Micol Massimiani, Ilenia Carriero, Claudia Bianco, Carlo Ticconi, Valentina Pavone, Alessandra Alteri, Ludovico Muzii, Rocco Rago, Valerio Pisaturo, Luisa Campagnolo
Evaluation of the optimal number of embryos, their quality, and the precise timing for transfer are critical determinants in reproductive success, although still remaining one of the main challenges in assisted reproduction technologies (ART). Indeed, the success of in vitro fertilization (IVF) treatments relies on a multitude of events and factors involving both the endometrium and the embryo. Despite concerted efforts on both fronts, the overall success rates of IVF techniques continue to range between 25% and 30%...
February 29, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472564/culture-media-affect-sex-after-ivf-treatment-a-detailed-analysis-of-explanatory-variables
#17
JOURNAL ARTICLE
T Guldager, A Gabrielsen, L H Iversen, K Kirkegaard
PURPOSE: The purpose of this study was to provide a detailed analysis of clinical and laboratory factors associated with skewed secondary sex ratio (SSR) after ART. METHOD: Retrospective cohort study of embryos resulting in live births, from frozen and fresh single blastocyst transfers. Embryos were cultured in either G-TL (n = 686) or Sage media (n = 685). Data was analyzed using a multivariate logistic regression model and a mixed model analysis...
March 13, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38472563/live-birth-outcomes-following-single-step-blastocyst-warming-technique-optimizing-efficiency-without-impacting-live-birth-rates
#18
JOURNAL ARTICLE
Victoria S Jiang, Panagiotis Cherouveim, Mackenzie N Naert, Irene Dimitriadis, Irene Souter, Charles L Bormann
PURPOSE: To evaluate the impact of a single-step (SS) warming versus standard warming (SW) protocol on the survival/expansion of vitrified blastocysts and their clinical outcomes post-frozen embryo transfer (FET). METHODS: Retrospective analysis was performed on 200 vitrified/warmed research blastocysts equally divided amongst two thawing protocols utilizing the Fujifilm Warming NX kits (Fujifilm, CA). SW utilized the standard 14-minute manufacturer's guidelines...
March 13, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38469148/effects-of-flaxseed-oil-supplementation-on-metaphase-ii-oocyte-rates-in-ivf-cycles-with-decreased-ovarian-reserve-a-randomized-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Qi Chu, Yue-Xin Yu, Jing-Zi Zhang, Yi-Tong Zhang, Jia-Ping Yu
BACKGROUND: This study was designed to explore the effects of flaxseed oil on the metaphase II (MII) oocyte rates in women with decreased ovarian reserve (DOR). METHODS: The women with DOR were divided into a study group (n = 108, flaxseed oil treatment) and a control group (n = 110, no treatment). All patients were treated with assisted reproductive technology (ART). Subsequently, the ART stimulation cycle parameters, embryo transfer (ET) results, and clinical reproductive outcomes were recorded...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38452358/does-recurrent-implantation-failure-exist-prevalence-and-outcomes-of-five-consecutive-euploid-blastocyst-transfers-in-123%C3%A2-987-patients
#20
JOURNAL ARTICLE
Pavan Gill, Baris Ata, Ana Arnanz, Danilo Cimadomo, Alberto Vaiarelli, Human M Fatemi, Filippo Maria Ubaldi, Juan A Garcia-Velasco, Emre Seli
STUDY QUESTION: What are the clinical pregnancy and live birth rates in women who underwent up to two more euploid blastocyst transfers after three failures in the absence of another known factor that affects implantation? SUMMARY ANSWER: The fourth and fifth euploid blastocyst transfers resulted in similar live birth rates of 40% and 53.3%, respectively, culminating in a cumulative live birth rate of 98.1% (95% CI = 96.5-99.6%) after five euploid blastocyst transfers...
March 7, 2024: Human Reproduction
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