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lymphoma nasopharynx

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https://www.readbyqxmd.com/read/27816363/patterns-of-primary-tumor-invasion-and-regional-lymph-node-spread-based-on-magnetic-resonance-imaging-in-early-stage-nasal-nk-t-cell-lymphoma-implications-for-clinical-target-volume-definition-and-prognostic-significance
#1
Run-Ye Wu, Kang Liu, Wei-Hu Wang, Jing Jin, Yong-Wen Song, Shu-Lian Wang, Yue-Ping Liu, Hua Ren, Hui Fang, Qing-Feng Liu, Yong Yang, Bo Chen, Shu-Nan Qi, Ning-Ning Lu, Yu Tang, Yuan Tang, Ning Li, Han Ouyang, Ye-Xiong Li
PURPOSE: This study aimed to determine the pathways of primary tumor invasion (PTI) and regional lymph node (LN) spread based on magnetic resonance imaging (MRI) in early-stage nasal NK/T-cell lymphoma (NKTCL), to improve clinical target volume (CTV) delineation and evaluate the prognostic value of locoregional extension patterns. METHODS AND MATERIALS: A total of 105 patients with newly diagnosed early-stage nasal NKTCL who underwent pretreatment MRI were retrospectively reviewed...
September 17, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27807488/uveitis-and-myositis-as-immune-complications-in-chemorefractory-nk-t-cell-nasal-type-lymphoma-successfully-treated-with-allogeneic-stem-cell-transplant
#2
Maria José Gómez-Crespo, Aránzazu García-Raso, Jose Luis López-Lorenzo, Teresa Villaescusa, María Rodríguez-Pinilla, José Fortes, Cristina Serrano, Salma Machan, Pilar Llamas, Raúl Córdoba
NK/T-cell lymphomas are a group of clonal proliferations of NK- or, rarely, T-cell types and have peculiar clinicopathologic features. Most common site of involvement is the upper aerodigestive tract (nasal cavity, nasopharynx, paranasal sinuses, and palate). Association of autoimmune paraneoplastic disorders with NK/T-cell lymphomas is not well studied. Our patient was diagnosed with NK/T-cell lymphoma stage IV with skin involvement and treated frontline with CHOEP regimen. While he was under treatment, two immune complications presented: anterior uveitis of autoimmune origin refractory to steroids and myositis in lower limbs muscles...
2016: Case Reports in Hematology
https://www.readbyqxmd.com/read/27757479/-diagnosis-and-treatment-of-parapharyngeal-space-tumors
#3
F Bootz, S Greschus, T van Bremen
The parapharyngeal space extends from the nasopharynx to the oropharynx. It is bordered medially by the pharyngeal wall and the constrictor pharyngis muscles, and laterally by the mandible. One distinguishes between a pre- and a poststyloid space. Tumors of the parapharyngeal space are rare and represent less than 1 % of all head and neck neoplasms. Benign (70-80 %) as well as malignant (20-30 %) tumors arise from different structures of the parapharyngeal space, mainly from salivary glands and nerve structures...
October 18, 2016: HNO
https://www.readbyqxmd.com/read/27692503/a-14-year-old-boy-with-extranodal-natural-killer-cell-lymphoma-of-the-nose-nasopharynx-larynx-and-trachea-in-remission-6years-after-primary-diagnosis-a-longitudinal-case-report
#4
Anil Gungor, Lindsey Pennington, Senthil Sankararaman, Samer Zaid-Kaylani, Majed Aldin Jeroudi
Nasal type extranodal natural killer/T-cell lymphoma (ENKTL) is a rare lymphoma in the USA and Europe but endemic in East Asia and in areas of South and Central America. Clinically natural killer cell lymphomas are divided into three categories; nasal, non-nasal and aggressive lymphoma/leukemia subtypes. ENKTL, nasal type occurs in the nose and can extend to the upper aero-digestive tract as reported in this longitudinal case study. This is a longitudinal report of progress of a 14-year-old boy with ENKTL originating in the nasal cavity with subsequent extension and recurrence in the contralateral nose, nasopharynx, larynx and trachea presenting with varying degrees of respiratory problems and eventually, respiratory distress...
August 12, 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27680487/extranodal-natural-killer-t-cell-lymphoma-nasal-type-with-primary-manifestation-as-an-upper-eyelid-swelling
#5
Akiko Kanzaki, Yoko Funasaka, Munenaga Nakamizo, Ayaka Shima, Takeshi Ryotokuji, Kazuo Dan, Mika Terasaki, Yuichi Sugisaki, Yu Fukuda, Seiji Kawana, Hidehisa Saeki
Extranodal natural killer/T-cell lymphoma (ENK/TCL) is most often in the nose or the nasopharynx but can present elsewhere. We report a rare case of ENK/TCL that presented as swelling of an upper eyelid without ocular involvement. A 76-year-old man visited our hospital with a swollen lesion of the left upper eyelid which had appeared 2 months earlier. A biopsy of the upper eyelid revealed slight perivascular and periadnexal infiltration of mononuclear cells with dermal edema. Treatment with oral prednisolone at a dosage of 20 mg/day decreased the eyelid swelling...
2016: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/27631245/hiv-and-cancer-registry-linkage-identifies-a-substantial-burden-of-cancers-in-persons-with-hiv-in-india
#6
Sheela V Godbole, Karabi Nandy, Mansi Gauniyal, Pallavi Nalawade, Suvarna Sane, Shravani Koyande, Joy Toyama, Asha Hegde, Phil Virgo, Kishor Bhatia, Ramesh S Paranjape, Arun R Risbud, Sam M Mbulaiteye, Ronald T Mitsuyasu
We utilized computerized record-linkage methods to link HIV and cancer databases with limited unique identifiers in Pune, India, to determine feasibility of linkage and obtain preliminary estimates of cancer risk in persons living with HIV (PLHIV) as compared with the general population.Records of 32,575 PLHIV were linked to 31,754 Pune Cancer Registry records (1996-2008) using a probabilistic-matching algorithm. Cancer risk was estimated by calculating standardized incidence ratios (SIRs) in the early (4-27 months after HIV registration), late (28-60 months), and overall (4-60 months) incidence periods...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27321059/epidemiological-evidence-on-environmental-tobacco-smoke-and-cancers-other-than-lung-or-breast
#7
Peter N Lee, Alison J Thornton, Janette S Hamling
We reviewed 87 epidemiological studies relating environmental tobacco smoke (ETS) exposure to risk of cancer other than lung or breast in never smoking adults. This updates a 2002 review which also considered breast cancer. Meta-analysis showed no significant relationship with ETS for nasopharynx cancer, head and neck cancer, various digestive cancers (stomach, rectum, colorectal, liver, pancreas), or cancers of endometrium, ovary, bladder and brain. For some cancers (including oesophagus, colon, gall bladder and lymphoma) more limited data did not suggest a relationship...
October 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27075854/association-between-hepatitis-c-virus-and-head-and-neck-cancers
#8
Parag Mahale, Erich M Sturgis, David J Tweardy, Ella J Ariza-Heredia, Harrys A Torres
BACKGROUND: Hepatitis C virus (HCV) infection is associated with hepatocellular carcinoma and non-Hodgkin's lymphoma. In 2009, MD Anderson established the first US clinic for treating HCV-infected cancer patients, where we observed an unexpectedly large number of patients with head and neck cancers (HNCs). We sought to determine whether HCV is associated with HNCs. METHODS: In this case-control study, medical records of cancer patients tested for HCV antibodies at our center from 2004 through 2014 were identified...
August 2016: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/26933411/extranodal-natural-killer-t-cell-lymphoma-of-the-nasal-type-with-skin-metastases
#9
Fadi Al Akhrass, Brooklyn Hensley, Lillian Thomas, Raymond Elsoueidi
Extranodal natural killer/T-cell lymphoma (ENKL) of the nasal type is a rare, clinically aggressive disease. ENKL of the nasal type is often localized in the upper aerodigestive tract, including the nasal cavity, nasopharynx, paranasal sinuses, tonsils, hypopharynx and larynx, and usually presents as stage I/II. Extranasal involvement can occur, and a common site of extranasal involvement or metastatic disease includes the skin. Identifying skin metastases is important for the appropriate staging and treatment...
January 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/26778387/expression-and-significance-of-ku80-and-pdgfr-%C3%AE-in-nasal-nk-t-cell-lymphoma
#10
Jun Li, Ping Chen, Wei Liu, Zian Xia, Feng Shi, Meizuo Zhong
BACKGROUND: To investigate the clinical and prognostic significance of Ku80 and PDGFR-α in nasal type NK/T cell lymphoma (NKTCL). METHODS: Immunohistochemistry for Ku80 and PDGFR-α was performed on tissue sections from 35 patients diagnosed with NKTCL. We analyzed the relationship between Ku80 and PDGFR-α expression and the clinicopathological features of NKTCL. We further performed multivariate analyses to identify prognostic factors for progression free survival (PFS) of patients...
March 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/26524027/-analysis-of-clinicopathological-characteristics-and-prognosis-of-112-patients-with-primary-waldeyer-s-ring-lymphoma
#11
Da-Lin Gao, Qian-Qian Fu, Tian-Tian Zhang, Shao-Ling Li, Yi Pan, Qiong-Li Zhai
OBJECTIVE: To investigate the clinical and pathological characteristics of patients with primary Waldeyer's ring lymphomas (PWRL), and to analyze its therapeutic efficacy and prognostic factors. METHODS: A total of 112 patients with PWRL confirmed by pathological and immunohistochemical methods between January 2009 and January 2014 were studied. Clinical data were collected and analyzed retrospectively. RESULTS: PWRL accounted for 3.9% of lymphoma over the same period...
October 2015: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/26290577/nonmuscle-myosin-heavy-chain-iia-mediates-epstein-barr-virus-infection-of-nasopharyngeal-epithelial-cells
#12
Dan Xiong, Yong Du, Hong-Bo Wang, Bo Zhao, Hua Zhang, Yan Li, Li-Juan Hu, Jing-Yan Cao, Qian Zhong, Wan-Li Liu, Man-Zhi Li, Xiao-Feng Zhu, Sai Wah Tsao, Lindsey M Hutt-Fletcher, Erwei Song, Yi-Xin Zeng, Elliott Kieff, Mu-Sheng Zeng
EBV causes B lymphomas and undifferentiated nasopharyngeal carcinoma (NPC). Although the mechanisms by which EBV infects B lymphocytes have been extensively studied, investigation of the mechanisms by which EBV infects nasopharyngeal epithelial cells (NPECs) has only recently been enabled by the successful growth of B lymphoma Mo-MLV insertion region 1 homolog (BMI1)-immortalized NPECs in vitro and the discovery that neuropilin 1 expression positively affects EBV glycoprotein B (gB)-mediated infection and tyrosine kinase activations in enhancing EBV infection of BMI1-immortalized NPECs...
September 1, 2015: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26141204/primary-mantle-cell-lymphoma-of-the-nasopharynx-a-rare-clinical-entity
#13
Ji-Hun Kang, Young-Dae Park, Chang-Hoon Lee, Kyu-Sup Cho
No abstract text is available yet for this article.
July 2015: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/26106000/histopathological-characteristics-of-lymphomas-in-the-upper-aerodigestive-tract-a-single-institute-study-in-japan
#14
Akiko Miyagi Maeshima, Hirokazu Taniguchi, Shinichi Makita, Hideaki Kitahara, Kenichi Miyamoto, Suguru Fukuhara, Wataru Munakata, Tatsuya Suzuki, Dai Maruyama, Yukio Kobayashi, Kensei Tobinai
We analyzed the histopathological characteristics of lymphomas biopsied from the upper aerodigestive tract between 2000 and 2014 at the National Cancer Center Hospital in Japan. Of a total of 309 consecutive cases, the following incidences were observed: mature B-cell neoplasms, 77% (n = 239); mature T- and NK-cell neoplasms, 20% (n = 63); classical Hodgkin lymphomas, 0.7% (n = 2); and lymphoblastic lymphomas, 2% (n = 5). Lymphomas were most frequently (57%) detected in the oropharynx. The majority of cases (89%) were mature B-cell neoplasms (diffuse large B-cell lymphoma, 60%; follicular lymphoma, 10%), and 10% of cases were mature T-cell neoplasms...
2015: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/25828281/prevalence-and-treatment-outcomes-of-second-primary-malignancies-in-saudi-patients-with-differentiated-thyroid-cancers
#15
Khalid H Al-Qahtani, Mushabbab Al-Asiri, Mutahir A Tunio, Naji J Aljohani, Yasser Bayoumi, Hussain Al-Hussain, Ahmad M Maklad
OBJECTIVES: To evaluate the clinicopathologic features, and explore the treatment outcomes of synchronous, or metachronous second primary malignancies (SPM) in conjunction with differentiated thyroid cancers (DTC). METHODS: This retrospective study was conducted on 823 DTC patients treated between 2000 and 2012 at 2 tertiary care hospitals (King Fahad Medical City and King Khalid University Hospital) in Riyadh, Kingdom of Saudi Arabia. Forty-one (5%) DTC patients were found to have SPM (61% metachronous and 39% synchronous)...
April 2015: Saudi Medical Journal
https://www.readbyqxmd.com/read/25665998/malignant-tumors-of-the-upper-aerodigestive-tract-as-seen-in-a-nigerian-tertiary-health-institution
#16
D Sabageh, T O Solaja, B J Olasode
BACKGROUND: Cancers of the upper aerodigestive tract constitute a diverse heterogeneous group of malignant neoplasms with unique epidemiological, pathological, and treatment considerations. Only few studies have been conducted so far on these tumors in Nigeria. This study aims to study in greater detail, the pathological features of these cancers in Nigerian patients. MATERIALS AND METHODS: The surgical specimens of patients diagnosed with malignant tumors of the upper aerodigestive tracts in the Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University Teaching Hospital Complex (OAUTHC) in Ile-Ife, Nigeria, over a 10-year period, formed the basis of this study...
March 2015: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/25654951/eight-years-of-clinical-findings-and-biopsy-results-of-nasopharyngeal-pathologies-in-1647-adult-patients-a-retrospective-study
#17
G Berkiten, T L Kumral, G Yildirim, Y Uyar, Y Atar, Z Salturk
OBJECTIVES: We performed an 8-year retrospective study to evaluate the presentation, clinical findings and nasopharyngeal biopsy results of adult nasopharyngeal pathologies. METHODOLOGY: This study included 1647 patients (801 males and 846 females) admitted to outpatient clinics. All patients underwent a nasopharyngeal biopsy for a nasopharyngeal mass. In addition, a blind biopsy was taken if there was suspicion of nasopharyngeal carcinoma, even in the absence of a mass lesion...
2014: B-ENT
https://www.readbyqxmd.com/read/25643759/hodgkin-lymphoma-of-the-nasopharynx-case-report-with-review-of-the-literature
#18
REVIEW
Adepitan A Owosho, Casey E Gooden, Alden G McBee
We report an uncommon case and histopathologic work-up of Hodgkin lymphoma of the nasopharynx in a 49-year old female patient who presented with a 2-year complaint of bilateral nasal congestion. Histologic study revealed a lymphocyte rich subtype of classic Hodgkin lymphoma. Immunohistochemical analysis revealed CD15, CD30, OCT-2, BOB.1, and MUM-1 expression by the neoplastic cells and a lack of expression of CD45, CD20, CD3, EMA, and EBER. The review of the literature showed that Hodgkin lymphoma of the nasopharynx is rare, the most common reported subtype is the mixed cellularity, and Hodgkin lymphoma of the nasopharynx has a favorable prognosis...
September 2015: Head and Neck Pathology
https://www.readbyqxmd.com/read/25580308/numb-chin-syndrome-as-first-symptom-of-diffuse-large-b-cell-lymphoma
#19
Mario Carbone, Francesco Della Ferrera, Lucio Carbone, Gaia Gatti, Marco Carrozzo
Numb chin syndrome is a rare sensory neuropathy of the mental nerve characterized by numbness, hypoesthesia, paraesthesia, and very rarely pain. Dental causes, especially iatrogenic ones, maxillofacial trauma, or malignant neoplasm are etiologic factors for this rare syndrome. Many malignant and metastatic neoplasms are causing this syndrome, like primary osteosarcoma, squamous cell carcinoma, and mandibular metastasis of primary carcinoma of breast, lung, thyroid, kidney, prostate, and nasopharynx. Haematological malignancies like acute lymphocytic leukaemia, Hodgkin and non-Hodgkin lymphoma, and myeloma can cause this neuropathy...
2014: Case Reports in Dentistry
https://www.readbyqxmd.com/read/25553969/extranodal-lymphoma-of-the-head-and-neck-a-67-case-series
#20
A Picard, C Cardinne, Y Denoux, I Wagner, F Chabolle, C A Bach
UNLABELLED: The present study sought to describe clinical presentation in extranodal lymphoma of the head and neck (ELHN), with the aim of improving diagnostic management. MATERIAL AND METHODS: A single-center retrospective observational study was conducted over the period 2001-13. Age, gender, histologic type, location, type of clinical presentation, time interval between symptom onset and histologic diagnosis and presence of specific symptoms were recorded, as were the specialty of the physician initially consulted and of the physician taking the diagnostic sample...
April 2015: European Annals of Otorhinolaryngology, Head and Neck Diseases
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