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nasopharyngeal malt lymphoma

Nilufer Yildirim-Poyraz, Elif Ozdemir, Abdulkadir Basturk, Aydan Kilicarslan, Seyda Turkolmez
Primary orbital lymphomas are rare; the major histopathologic type is extranodal marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) or MALToma. We present a case of a 79-year-old female patient with FDG-avid lacrimal gland MALToma with nodal and pulmonary involvement (stage IVE). Nasopharynx and gastric involvement were detected on restaging F-FDG PET/CT after rituximab therapy, and it was found to have a site of transformation to diffuse large B-cell lymphoma (DLBCL) in the nasopharynx...
February 2015: Clinical Nuclear Medicine
Ajaykumar Patel, Mahmut Ozsahin, Rene-Olivier Mirimanoff, Sumita Bhatia, Kenneth Chang, Robert Clell Miller
The Rare Cancer Network (RCN), founded in 1993, performs research involving rare tumors that are not common enough to be the focus of prospective study. Over 55 studies have either been completed or are in progress.The aim of the paper is to present an overview of the 30 studies done through the RCN to date, organized by disease site. Five studies focus on breast pathology, including sarcoma, lymphoma, phyllodes tumor, adenoid cystic carcinoma, and ductal carcinoma in situ in young women. Three studies on prostate cancer address prostatic small cell carcinoma and adenocarcinoma of young and elderly patients...
June 26, 2012: Rare Tumors
Triantafyllia Koletsa, Georgios Petrakis, Georgia Karayannopoulou, Dimitrios Pappas, Konstantinos Markou, Georgios Karkavelas, Ioannis Kostopoulos
Synchronous malignancy of squamous cell carcinoma and malignant lymphoma in the head and neck region is extremely rare. Nasopharyngeal carcinoma is a nonlymphomatous, squamous cell carcinoma that occurs in the nasopharyngeal epithelium. Reported herein is a unique case of nasopharyngeal carcinoma occurring simultaneously with MALT-type lymphoma in an 83-year-old woman, who complained of deglutition dysfunction. Endoscopic examination of respective organs revealed a submucosal tumour on the posterior wall of pharynx...
2011: Pathology Research International
Wesley O Greaves, Sa A Wang
Lymphoid tissue located in the head and neck region include multiple regional lymph node chains as well as mucosa associated lymphoid tissue of the conjunctiva, buccal and nasopharyngeal cavities (Waldeyer's ring), and thyroid and salivary glands. This region is a rich source of antigenic stimuli including infectious agents coming from the outside environment. Many reactive conditions that affect lymphoid tissue in this region may mimic neoplasia. In fact, distinguishing between benign and malignant lymphoid proliferations in the head and neck region is a relatively frequent diagnostic challenge and in many instances, this distinction is not straightforward...
March 2011: Head and Neck Pathology
Wah Cheuk, Hunter K L Yuen, Alexander C L Chan, Lee-Yung Shih, Tseng-Tong Kuo, Ming-Wai Ma, Yan-Fai Lo, Wai-Kong Chan, John K C Chan
IgG4-related sclerosing disease is a recently recognized inflammatory lesion frequently involving pancreas, submandibular gland, lacrimal gland, and lymph node. We report 3 cases of ocular adnexal lymphoma arising in IgG4-related chronic sclerosing dacryoadenitis, a phenomenon that has not been previously reported. The patients presented with bilateral or unilateral ocular adnexal mass usually present for many years. One patient also had asymptomatic diffuse lymphadenopathy. Two patients had biopsy-proven IgG4-related chronic sclerosing dacryoadenitis before the current presentation, and 1 had systemic involvement by IgG4-related sclerosing disease as evidenced by increased IgG4+ cells in a prior nasopharyngeal biopsy...
August 2008: American Journal of Surgical Pathology
Yan-Fen Feng, Qiu-Liang Wu, Yong-Sheng Zong
BACKGROUND & OBJECTIVE: There are differences in the prevalence rate and composition of immunophenotypes of sinonasal non-Hodgkin's lymphoma (NHL) depending on the geography. This study was to investigate the immunophenotypes of sinonasal NHLs and their relationship to Epstein-Barr virus (EBV) infection in Guangzhou, China. METHODS: Fifty-seven NHL samples of the sinonasal region were collected from the Department of Pathology, Cancer Center of Sun Yat-sen University from Apr...
November 2007: Ai Zheng, Aizheng, Chinese Journal of Cancer
Amira Kamal El-Hawary
INTRODUCTION: MALT lymphoma arises in a variety of body tissues, but most often in the stomach. Though relatively rare, these MALT lymphomas may arise within several sites in the head and neck, and often present diagnostic and therapeutic challenges. Immunohistochemical analysis are helpful in confirming the diagnosis between the MALT-lymphoma and the reactive lymphoid hyperplasia. MALT-type lymphoma demonstrated characteristic negative staining for CD3, CD5 and CD43, positive staining for CD20, and monotypic staining for either kappa or lambda light chain immunoglobulin markers, whereas reactive lymphoid hyperplasia all expressed B and T cell markers...
June 2006: Journal of the Egyptian National Cancer Institute
Sarah E Coupland, Doris Jaehne, Michael Hummel, Harald Stein
PURPOSE: To report a case of a MALT lymphoma of the eyelid, which recurred in several sites over a time period of 14 years, and where the identical B-cell clone could be demonstrated in most samples using polymerase chain reaction (PCR) and GeneScan analysis. METHODS: Clinical, histologic, immunohistochemical, PCR and GeneScan analysis findings are presented. RESULTS: A 58-year-old woman presented with a swelling of the left lower lid. Excisional biopsy of the tumour revealed a low-grade malignant B-cell Non-Hodgkin lymphoma (NHL) of MALT type...
July 2007: Graefe's Archive for Clinical and Experimental Ophthalmology
C Frieke Kuper
Mucosa-associated lymphoid tissue (MALT) is a generalized term incorporating a disseminated collection of lymphoid tissues in multiple sites throughout the body. MALT sites that have been/are primarily studied include bronchus-associated lymphoid tissue (BALT), gut-associated lymphoid tissue (GALT), and nasopharynx-associated lymphoid tissue (NALT). Since MALT sites are often under-sampled in conventional toxicity studies, MALT lesions have not been extensively documented in these lymphoid effector sites. Lesions of the nasopharyngeal lymphoid tissue and Peyer's patches include degeneration, inflammation, and both primary and metastatic neoplasia...
2006: Toxicologic Pathology
Omar A El-Banhawy, Ibraheim El-Desoky
BACKGROUND: Malignant tumors of the nasopharynx are always a challenging problem, both from the diagnostic and from the therapeutic standpoint. Most extranodal lymphomas arise in the gastrointestinal tract, but the other mucosal organs also may be involved, especially the upper aerodigestive tract. Nasopharyngeal lymphomas are rare among lymphoma of the upper aerodigestive tract. METHODS: Twenty-two patients with primary lymphoma arising in mucosa-associated lymphoid tissue of the nasopharynx have been studied with reference to age, sex, clinical symptoms, laboratory finding, radiological finding, histological subtype, and immunohistochemistry...
July 2005: American Journal of Rhinology
L H Tan
INTRODUCTION: This review revisits Waldeyer's ring lymphomas as classified by the World Health Organisation. MATERIALS AND METHODS: Sources of data include international studies on Waldeyer's ring lymphomas as well as from personal observations gleaned from lymphoma statistics of Singapore General Hospital, Changi General Hospital, Tan Tock Seng Hospital and National University Hospital within the last decade or so. RESULTS: Waldeyer's ring shares many of the histopathological trends of the rest of mucosa-associated lymphoid tissue (MALT), such as the high frequency of diffuse large B-cell lymphomas, and the relative rarity of follicular lymphomas in spite of its rich endowment with reactive lymphoid follicles...
July 2004: Annals of the Academy of Medicine, Singapore
Eduardo Prades, Isam Alobid, Llucia Alós, Jose Maria Guilemany, Manuel Bernal-Sprekelsen, Joaquim Mullol
Non-Hodgkin's lymphoma originating from mucosa-associated lymphoid tissue has been connected with autoimmune disease. These tumours often arise in gastric mucosa and are extremely rare in airway mucosa. Three cases of mucosa-associated lymphoid tissue lymphoma in the cavum have been reported in the literature. A 52-year-old male with rheumatoid arthritis presented with an 8-month history of nasal obstruction and recurrent nasal blood discharge. On physical examination a bulky mass was observed in the nasopharynx...
December 2003: Acta Oto-laryngologica
K Sundaram, B Singh, G Har-El
No abstract text is available yet for this article.
January 1999: American Journal of Otolaryngology
V Ascoli, F Lo Coco, M Artini, M Levrero, M Martelli, F Negro
Hepatitis C virus (HCV) infection may be complicated by non-Hodgkin's lymphoma. We describe eight cases of B-cell extranodal non-Hodgkin's lymphoma occurring during the course of chronic HCV-related hepatic disease (low-grade of mucosa-associated lymphoid tissue [MALT]-type; diffuse large cell; Burkitt; diffuse small cell). Some were localized to the liver (2), liver and spleen (1), spleen (1), peritoneal cavity (1), parotid gland (1); others manifested in the nasopharynx (1) and eyelid (1) but were accompanied by nodal disease...
May 1998: American Journal of Clinical Pathology
G Seifert
Diagnostic pitfalls exist when benign salivary gland diseases are mistakenly classified as malignant, with consequences for treatment and prognosis. Examples are necrotizing sialometaplasia, metaplastic Warthin tumour and sclerosing polycystic sialadenopathy. The proper diagnosis is of eminent importance to distinguish cases of primary tumours that have developed in salivary glands or their lymph nodes from cases of extraglandular tumours with metastases in these glands or their nodes. In these cases clinical data and additional immunocytochemical methods are necessary to clarify the exact diagnosis, especially when the primary salivary gland tumours have a structure largely identical to the metastases (e...
March 1998: Mund-, Kiefer- und Gesichtschirurgie: MKG
O M Koch, M Probst, M Tiemann, I Jakob, M Volkenandt, R Wienecke, J Buer, J Atzpodien, H J Lenz, P V Danenberg
Analysis of complementary RNA molecules of junctional regions of rearranged T-cell-receptor-gamma genes show a pattern of conformational polymorphisms which is specific for an individual lymphocytic clone. In a blinded study we analysed formalin-fixed, paraffin-embedded histological specimens from gastrointestinal lymphomas and control tissues (lymphomas: pleomorphic T-cell 10, anaplastic large cell [Ki1+] 9, centroblastic 5, immunocytoma 1, B-CLL 2, Hodgkin's 2, centroblastic-centrocytic 1, MALT [mucosa associated lymphoid tissue] 1, T-cell acute lymphoblastic leukaemia 1, non-lymphoid or polyclonal lymphoid tissues 5)...
February 1994: British Journal of Haematology
J Menárguez, M Mollejo, R Carrión, H Oliva, C Bellas, J Forteza, C Martin, C Ruiz-Marcellán, M Morente, V Romagosa
Waldeyer ring lymphomas belong to a category of tumours which has not yet been fully defined. Their relation to mucosa-associated lymphoid tissue (MALT) and other extranodal lymphomas remains largely unknown. We performed a clinicopathological retrospective study of 79 patients, and compared them with a series of MALT and nodal lymphomas. Tumours from the nasopharynx and palatine tonsil showed similar histological profiles, with a predominance of large B-cells. Centroblastic lymphomas constituted the largest group (n = 45), followed by those of centrocytic type (9) with smaller groups of centroblastic-centrocytic (5) and Hodgkin's lymphomas (2)...
January 1994: Histopathology
Q Liu, K Ohshima, Y Masuda, M Kikuchi
The Epstein-Barr virus (EBV) has been shown to be associated with numerous human malignancies including Burkitt's lymphoma and nasopharyngeal lymphoepithelioma. In addition, some typical gastric adenocarcinomas were also recently reported to demonstrate EBV relevance. The present study was designed to detect EBV in primary gastric lymphoma, using the in situ hybridization (ISH) method, in which oligonucleotide probes for the EBER1 RNA and the EBV DNA W region have been used. Of the 49 cases of primary gastric lymphoma studied, which all showed B cell immunophenotype, EBER1 sequences could only be found in four cases, including two low-grade cases and two high-grade cases of histological subtypes while the number of positive cells was less than 50% of the tumor cells...
February 1995: Pathology International
J K Chan, C S Ng, S T Lo
Among extranodal lymphomas, the Waldeyer's ring is the second most frequently involved site after the gastrointestinal tract. Fresh tissue from 23 consecutive cases of malignant lymphoma of the faucial tonsil, palate and base of tongue were studied histologically and with a panel of 25 monoclonal antibodies. Twenty cases were primary Waldeyer's ring lymphoma, and all were found to express B-cell phenotype. Most cases were classified as diffuse centroblastic lymphoma, polymorphic subtype, in which there were immunoblast-like, centrocyte-like and/or multilobated centroblasts...
September 1987: Histopathology
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