keyword
MENU ▼
Read by QxMD icon Read
search

Aging epigenetics histone

keyword
https://www.readbyqxmd.com/read/29049850/-epigenetic-control-of-early-neurodegenerative-events-in-diabetic-retinopathy-by-the-histone-deacetylase-sirt6
#1
María A Zorrilla-Zubilete, Ada Yeste, Francisco J Quintana, Debra Toiber, Raul Mostoslavsky, Dafne M Silberman
Diabetic retinopathy (DR) is one of the common complications associated with diabetes mellitus (DM) and the leading cause of blindness worldwide. Recent research has demonstrated that DR is not only a microvascular disease but may be a result of neurodegenerative processes. Moreover, glucose-induced neuron and glial cell damage may occur shortly after the onset of diabetes which makes the disease hard to diagnose at early stages. SIRT6, a NAD-dependent sirtuin deacylase, modulates aging, energy metabolism and neurodegeneration...
October 19, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29037228/neuroepigenetic-mechanisms-in-disease
#2
REVIEW
Michael A Christopher, Stephanie M Kyle, David J Katz
Epigenetics allows for the inheritance of information in cellular lineages during differentiation, independent of changes to the underlying genetic sequence. This raises the question of whether epigenetic mechanisms also function in post-mitotic neurons. During the long life of the neuron, fluctuations in gene expression allow the cell to pass through stages of differentiation, modulate synaptic activity in response to environmental cues, and fortify the cell through age-related neuroprotective pathways. Emerging evidence suggests that epigenetic mechanisms such as DNA methylation and histone modification permit these dynamic changes in gene expression throughout the life of a neuron...
October 16, 2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/29025858/histone-modifications-regulate-the-developmental-expression-of-human-hepatic-ugt1a1
#3
Ya-Li Nie, Xiang-Guang Meng, Jing-Yang Liu, Liang Yan, Pei Wang, Hong-Zheng Bi, Quan-Cheng Kan, Li-Rong Zhang
Human UDP-glucuronosyltransferase 1A1 (UGT1A1) is a unique enzyme involved in bilirubin conjugation. We previously characterized the hepatic expression of transcription factors affecting UGT1A1 expression during development. Accordingly, in this study, we characterized the ontogenetic expression of hepatic UGT1A1 from the perspective of epigenetic regulation. We observed significant histone-3-lysine-4 dimethylation (H3K4me2) enrichment in the adult liver and histone-3-lysine-27 trimethylation (H3K27me3) enrichment in the fetal liver, indicating that dynamic alterations of histone methylation were associated with ontogenetic UGT1A1 expression...
October 12, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29018479/epigenetic-regulation-of-cellular-senescence-and-aging
#4
REVIEW
Corinne Sidler, Olga Kovalchuk, Igor Kovalchuk
Aging is characterized by functional decline of diverse organs and an increased risk for several diseases. Therefore, a high interest exists in understanding the molecular mechanisms that stimulate aging at all levels, from cells and tissues to organs and organisms, in order to develop ways to promote healthy aging. While many molecular and biochemical mechanisms are already understood in some detail, the role of changes in epigenetic regulation has only begun to be considered in recent years. The age-dependent global reduction in heterochromatin, along with site-specific changes in the patterns of DNA methylation and modification of histones, have been observed in several aging model systems...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29017914/the-roles-of-class-i-histone-deacetylases-hdacs-in-memory-learning-and-executive-cognitive-functions-a-review
#5
REVIEW
Claudia Schmauss
Coordinated changes in gene expression are critical for synaptic plasticity supporting learning, memory, and optimal cognitive task performance. These gene expression changes are not only mediated by signaling pathways that activate transcription factors, but also by chromatin modifications that influence the accessibility of the transcriptional machinery to specific genomic regions. During the past decade, evidence accumulated that alterations in chromatin-based epigenetic regulation of gene expression are linked to cognitive dysfunctions in the ageing or neurodegenerating brain as well as to cognitive dysfunctions resulting from chronic stress exposure...
October 7, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28988828/epigenetics-and-cardiovascular-regenerative-medicine-in-the-elderly
#6
REVIEW
Sarah Costantino, Giovanni G Camici, Shafeeq Ahmed Mohammed, Massimo Volpe, Thomas F Lüscher, Francesco Paneni
Cardiovascular disease (CVD) is a recognized age-dependent condition whose incidence is set to increase due to the gradual aging of the population. Moreover, ischemic cardiovascular diseases (i.e. stroke, myocardial infarction, critical limb ischemia) requiring blood vessel growth are associated with a worse outcome in elderly patients. Therefore, understanding the molecular cues regulating the vascular repair process is of paramount importance to prevent undesirable cardiovascular complications in this setting...
September 27, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28984297/expression-patterns-of-class-i-histone-deacetylases-in-osteosarcoma-a-novel-prognostic-marker-with-potential-therapeutic-implications
#7
Parunya Chaiyawat, Dumnoensun Pruksakorn, Areerak Phanphaisarn, Pimpisa Teeyakasem, Jeerawan Klangjorhor, Jongkolnee Settakorn
Epigenetic aberrations are recognized as having pivotal roles in cancer etiology and progression. Histone deacetylases are among the most studied epigenetic modulators in various cancer types. The expression levels of class I histone deacetylase isoforms 1, 2, and 3 in patient-derived primary osteosarcoma cells (6 cases) was investigated, comparing them to normal bone graft-derived osteoblasts (6 cases) using the immunoblotting technique. Expression profiles of histone deacetylases in high-grade osteosarcoma tissue of 89 patients were examined and their association with clinicopathologic parameters and the patient survival was evaluated...
October 6, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28976920/chronic-%C3%AE-%C3%A2-thc-exposure-differently-affects-histone-modifications-in-the-adolescent-and-adult-rat-brain
#8
Pamela Prini, Federica Penna, Emanuele Sciuccati, Tiziana Alberio, Tiziana Rubino
Adolescence represents a vulnerable period for the psychiatric consequences of delta9-tetrahydrocannabinol (Δ⁸-THC) exposure, however, the molecular underpinnings of this vulnerability remain to be established. Histone modifications are emerging as important epigenetic mechanisms involved in the etiopathogenesis of psychiatric diseases, thus, we investigated the impact of chronic Δ⁸-THC exposure on histone modifications in different brain areas of female rats. We checked histone modifications associated to both transcriptional repression (H3K9 di- and tri-methylation, H3K27 tri-methylation) and activation (H3K9 and H3K14 acetylation) after adolescent and adult chronic Δ⁸-THC exposure in the hippocampus, nucleus accumbens, and amygdala...
October 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28968025/-the-role-of-interactions-of-transposons-with-epigenetic-factors-in-the-aging-process
#9
R N Mustafin, E K Khusnutdinova
The review considers modern theories of aging mechanisms and data on epigenetic regulation of ontogenesis. Transposons may be the material bases of the epigenetic control system, their movements affect the differentiation of cells and can cause genomic instability. Control systems aimed at protecting against foreign DNA (splicing machine, microRNA processing) became the basis of regulatory networks of genomes underlying cell differentiation. Transposon sequences are the basis for non-coding RNAs that suppress the expression of the transposons themselves and protein-coding genes at the posttranscriptional level, as well as by altering the activity of methyltransferases and modifying the histone modification...
2017: Advances in Gerontology, Uspekhi Gerontologii
https://www.readbyqxmd.com/read/28967098/epigenetic-regulation-of-melatonin-receptors-in-neuropsychiatric-disorders
#10
REVIEW
Sarra G Bahna, Lennard P Niles
Melatonin, the primary indoleamine hormone of the mammalian pineal gland, is known to have a plethora of neuroregulatory, neuroprotective and other properties. Melatonergic signaling is mediated by its two G protein-coupled receptors, MT1 and MT2 , which are widely expressed in the mammalian CNS. Melatonin levels and receptor expression often show a decrease during normal aging, and this reduction may be accelerated in some disease states. Depleted melatonergic signaling has been associated with neuropsychiatric dysfunction and impairments in cognition, memory, neurogenesis and neurorestorative processes...
October 2, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28964938/impact-of-dna-methylation-programming-on-normal-and-pre-leukemic-hematopoiesis
#11
REVIEW
Jens Langstein, Michael D Milsom, Daniel B Lipka
Epigenome regulation is a critical mechanism that governs cell identity, lineage specification and developmental cell fates. With the advent of low-input and single-cell technologies as well as sophisticated cell labeling techniques, our understanding of transcriptional and epigenetic regulation of hematopoiesis is currently undergoing dramatic changes. Increasingly, evidence suggests that the epigenome conformation acts as a critical decision-making mechanism that instructs self-renewal, differentiation and developmental fates of hematopoietic progenitor cells...
September 27, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28960024/new-aspects-of-vascular-calcification-histone-deacetylases-and-beyond
#12
REVIEW
Duk Hwa Kwon, Young Kook Kim, Hyun Kook
Vascular calcification is a pathologic phenomenon in which calcium phosphate is ectopically deposited in the arteries. Previously, calcification was considered to be a passive process in response to metabolic diseases, vascular or valvular diseases, or even aging. However, now calcification is recognized as a highly-regulated consequence, like bone formation, and many clinical trials have been carried out to elucidate the correlation between vascular calcification and cardiovascular events and mortality. As a result, vascular calcification has been implicated as an independent risk factor in cardiovascular diseases...
November 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28951285/maternal-consumption-of-high-fat-diet-and-grape-juice-modulates-global-histone-h4-acetylation-levels-in-offspring-hippocampus-a-preliminary-study
#13
Luciana Kneib Gonçalves, Ivy Reichert Vital da Silva, Laura Reck Cechinel, Marina Rocha Frusciante, Alexandre Silva de Mello, Viviane Rostirola Elsner, Claudia Funchal, Caroline Dani
This study aimed to investigate the impact of maternal consumption of a hyperlipid diet and grape juice on global histone H4 acetylation levels in the offsprinǵs hippocampus at different stages of development. During pregnancy and lactation of offspring, dams were divided into 4 groups: control diet (CD), high-fat diet (HFD), control diet and purple grape juice (PGJCD) and purple grape juice and high-fat diet (PGJHFD). Male Wistar rats were euthanized at 21days of age (PN21, adolescents) and at 50days of age (PN50, adults)...
September 23, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28887637/epigenetic-regulation-in-cell-senescence
#14
REVIEW
Li-Qin Cheng, Zhu-Qin Zhang, Hou-Zao Chen, De-Pei Liu
Cell senescence, which is an irreversible state of cell proliferative arrest, has emerged as a potentially important contributor to tissue dysfunction and organismal ageing. Cell senescence is triggered by a variety of senescence stressors, which affect gene expression and multiple signalling pathways that give rise to various senescence phenotypes. Epigenetic mechanisms, as critical regulators of chromosomal architecture and gene expression, have added an extra dimension to the molecular mechanisms of cell senescence...
September 8, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28843433/hdac-inhibitors-a-new-promising-drug-class-in-anti-aging-research
#15
REVIEW
Elena G Pasyukova, Alexander M Vaiserman
In the last years, epigenetic regulation of gene expression is regarded as an important factor involved in a broad spectrum of aging-associated processes including loss of physical activity, frailty and genomic instability, and in development of various pathological conditions such as atherosclerosis, type 2 diabetes, cancer, immune deficits and neurodegenerative diseases. Accordingly, inhibitors of the members of superfamilies of histone deacetylases (HDACs) have been proposed, among other drugs targeting epigenetic pathways, as a promising type of therapeutics that is able to combat aging and its manifestations...
August 24, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28833141/transcriptional-profiling-of-human-neural-precursors-post-alcohol-exposure-reveals-impaired-neurogenesis-via-dysregulation-of-erk-signaling-and-mir-145
#16
Lithin K Louis, Renjitha Gopurappilly, Harshini Surendran, Sunit Dutta, Rajarshi Pal
Gestational alcohol exposure causes a range of neuropsychological disorders by modulating neurodevelopmental genes and proteins. The extent of damage depends on the stage of the embryo, as well as dosage, duration, and frequency of exposure. Here, we investigated the neurotoxic effects of alcohol using Human Embryonic Stem Cells (hESC). Multiple read-outs were engaged to assess the proliferation and differentiation capacity of neural precursor cells (NPC) upon exposure to 100 mM ethanol for 48 hrs corresponding to the blood alcohol levels for binge drinkers...
August 21, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28831600/encouraging-results-with-the-compassionate-use-of-hydralazine-valproate-transkrip%C3%A2-as-epigenetic-treatment-for-myelodysplastic-syndrome-mds
#17
Myrna Candelaria, Sebastian Burgos, Mayra Ponce, Ramiro Espinoza, Alfonso Dueñas-Gonzalez
The hypomethylating agents azacytidine and decitabine are unaffordable for many patients with MDS. The combination of the DNA methyltransferase inhibitor hydralazine and the histone deacetylase inhibitor valproate has shown preliminary efficacy in MDS. The aim of this study is to evaluate the clinical efficacy and safety of hydralazine/valproate in a case series of MDS patients treated in a compassionate manner. Hydralazine was dosed according to the acetylation genotype of patients (slow acetylators 83 mg daily; fast acetylators 182 mg daily), and valproate was dosed at 30 mg/kg/day...
August 23, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28830839/the-potential-for-targeted-rewriting-of-epigenetic-marks-in-copd-as-a-new-therapeutic-approach
#18
REVIEW
Dan-Dan Wu, Juan Song, Sabine Bartel, Susanne Krauss-Etschmann, Marianne G Rots, Machteld N Hylkema
Chronic obstructive pulmonary disease (COPD) is an age and smoking related progressive, pulmonary disorder presenting with poorly reversible airflow limitation as a result of chronic bronchitis and emphysema. The prevalence, disease burden for the individual, and mortality of COPD continues to increase, whereas no effective treatment strategies are available. For many years now, a combination of bronchodilators and anti-inflammatory corticosteroids has been most widely used for therapeutic management of patients with persistent COPD...
August 19, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28827187/epigenetics-in-osteoarthritis-potential-of-hdac-inhibitors-as-therapeutics
#19
REVIEW
Nazir M Khan, Tariq M Haqqi
Osteoarthritis (OA) is the most common joint disease and the leading cause of chronic disability in middle-aged and older populations worldwide. The development of disease modifying therapy for OA is in its infancy largely because the regulatory mechanisms for the molecular effectors of OA pathogenesis are poorly understood. Recent studies identified epigenetic events as a critical regulator of molecular players involved in the induction and development of OA. Epigenetic mechanisms include DNA methylation, non-coding RNA and histone modifications...
August 18, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28826859/tet2-restrains-inflammatory-gene-expression-in-macrophages
#20
Alyssa H Cull, Brooke Snetsinger, Rena Buckstein, Richard A Wells, Michael J Rauh
Tet methylcytosine dioxygenase 2 (TET2) is one of the earliest and most frequently mutated genes in clonal hematopoiesis of indeterminate potential (CHIP) and myeloid cancers, including myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML). TET2 catalyzes the oxidation of 5-methylcytosine to 5-hydroxymethylcytosine, leading to DNA demethylation, and also affects transcription by recruiting histone modifiers. Inactivating TET2 mutations cause epigenetic dysregulation, clonal hematopoietic stem cell (HSC) dominance, and monocytic lineage skewing...
August 18, 2017: Experimental Hematology
keyword
keyword
98097
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"