keyword
MENU ▼
Read by QxMD icon Read
search

patrolling monocytes

keyword
https://www.readbyqxmd.com/read/29467472/effector-cd4-t-cells-recognize-intravascular-antigen-presented-by-patrolling-monocytes
#1
Clare L V Westhorpe, M Ursula Norman, Pam Hall, Sarah L Snelgrove, Michaela Finsterbusch, Anqi Li, Camden Lo, Zhe Hao Tan, Songhui Li, Susan K Nilsson, A Richard Kitching, Michael J Hickey
Although effector CD4+ T cells readily respond to antigen outside the vasculature, how they respond to intravascular antigens is unknown. Here we show the process of intravascular antigen recognition using intravital multiphoton microscopy of glomeruli. CD4+ T cells undergo intravascular migration within uninflamed glomeruli. Similarly, while MHCII is not expressed by intrinsic glomerular cells, intravascular MHCII-expressing immune cells patrol glomerular capillaries, interacting with CD4+ T cells. Following intravascular deposition of antigen in glomeruli, effector CD4+ T-cell responses, including NFAT1 nuclear translocation and decreased migration, are consistent with antigen recognition...
February 21, 2018: Nature Communications
https://www.readbyqxmd.com/read/29445379/contribution-of-regulatory-t-cells-in-nucleotide-binding-oligomerization-domain-2-response-to-influenza-virus-infection
#2
Benoit Egarnes, Jean Gosselin
Influenza A virus (IAV) is recognized to cause severe pulmonary illnesses in humans, particularly in elderly and children. One of the features associated with IAV infection is an excessive lung inflammation due to an uncontrolled immune response. The nucleotide-binding oligomerization domain 2 (NOD2) receptor is known to recognize ssRNA viruses such as IAV, but its role in the inflammatory process during viral infections remains to be clarified. In a previous report, we have shown that activation of NOD2 with muramyl dipeptide (MDP) significantly reduces both viral loads and lung inflammation and also improves pulmonary function during IAV infection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29440458/macrophage-targeting-fasudil-treatment-protects-liver-from-the-ischemia-reperfusion-injury-by-promoting-m2-macrophage-polarization
#3
Yingli Xie, Di Zhao, Pingshuan Dong, Lihong Lai
Macrophages play essential roles in the generation and resolution of inflammation. Ischemia-reperfusion injury (IRI) triggers a systemic inflammatory response and leads to cellular injury and organ failure. During surgical procedures of the liver, such as hepatic resection and liver transplantation, IRI leads to the dysfunction of the liver. Rho-associated protein kinase (ROCK) inhibitors were reported protecting the liver from IRI. However, the systematic administration of ROCK inhibitors causes severe hypotension...
February 12, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29367702/angiogenic-factor-driven-inflammation-promotes-extravasation-of-human-proangiogenic-monocytes-to-tumours
#4
Adama Sidibe, Patricia Ropraz, Stéphane Jemelin, Yalin Emre, Marine Poittevin, Marc Pocard, Paul F Bradfield, Beat A Imhof
Recruitment of circulating monocytes is critical for tumour angiogenesis. However, how human monocyte subpopulations extravasate to tumours is unclear. Here we show mechanisms of extravasation of human CD14dimCD16+ patrolling and CD14+CD16+ intermediate proangiogenic monocytes (HPMo), using human tumour xenograft models and live imaging of transmigration. IFNγ promotes an increase of the chemokine CX3CL1 on vessel lumen, imposing continuous crawling to HPMo and making these monocytes insensitive to chemokines required for their extravasation...
January 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29290545/immune-regulation-by-monocytes
#5
REVIEW
Peter J Murray
Monocytes emerging from the bone marrow are the progenitors of monocyte-derived macrophages. An essential function of monocytes is to seed tissues with sufficient macrophages to replace loss from infection and tissue damage. Recent work from diverse inflammatory and homeostatic settings has shown monocytes also possess direct protective and pathogenic activities. Thus, monocytes are not simply needed to generate macrophages, but instead contribute to the overall orchestration of immunity. Some recently described properties of monocytes are both surprising and mechanistically specific; for example, inflammatory monocytes are required for the efficacy of transferred activated cytotoxic T cells, but can have potent tissue damaging effects while patrolling monocytes are required for anti-tumor immunity in some cases, but in another example provokes resistance to chemotherapy and thereby aid tumor growth...
December 28, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/29194752/the-regulatory-role-of-the-oral-commensal-streptococcus-mitis-on-human-monocytes
#6
Stian André Engen, Olav Schreurs, Fernanda Petersen, Inger Johanne Schytte Blix, Espen S Baekkevold, Karl Schenck
Streptococcus mitis colonizes all niches of the human oral cavity from early infancy and throughout life. Monocytes patrol blood vessels, lymphoid and non-lymphoid tissues, and migrate into infected tissue where they participate in the inflammatory cascade and immune regulation. Here, we studied the effect of S. mitis on monocytes. Transcriptome analysis of monocytes exposed to S. mitis (SmMo) revealed increased transcription of chemotactic factors (CCL2, CCL3, CCL20, CXCL1, CXCL2) and cytokines (IL1A, IL1B, IL6, IL23, IL36G, TNF), indicating that S...
December 1, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29105655/pre-metastatic-cancer-exosomes-induce-immune-surveillance-by-patrolling-monocytes-at-the-metastatic-niche
#7
Michael P Plebanek, Nicholas L Angeloni, Elena Vinokour, Jia Li, Anna Henkin, Dalia Martinez-Marin, Stephanie Filleur, Reshma Bhowmick, Jack Henkin, Stephen D Miller, Igal Ifergan, Yesung Lee, Iman Osman, C Shad Thaxton, Olga V Volpert
Metastatic cancers produce exosomes that condition pre-metastatic niches in remote microenvironments to favor metastasis. In contrast, here we show that exosomes from poorly metastatic melanoma cells can potently inhibit metastasis to the lung. These "non-metastatic" exosomes stimulate an innate immune response through the expansion of Ly6C(low) patrolling monocytes (PMo) in the bone marrow, which then cause cancer cell clearance at the pre-metastatic niche, via the recruitment of NK cells and TRAIL-dependent killing of melanoma cells by macrophages...
November 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/29045904/inkt-cells-orchestrate-a-switch-from-inflammation-to-resolution-of-sterile-liver-injury
#8
Pei Xiong Liew, Woo-Yong Lee, Paul Kubes
After traumatic injury, some cells function as detectors to sense injury and to modulate the local immune response toward a restitution phase by affecting the local cytokine milieu. Using intravital microscopy, we observed that patrolling invariant natural killer T (iNKT) cells were initially excluded from a site of hepatic injury but subsequently were strategically arrested first via self-antigens and then by cytokines, circumscribing the injured site at exactly the location where monocytes co-localized and hepatocytes proliferated...
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29042196/dcir3-and-dcir4-are-co-expressed-on-inflammatory-and-patrolling-monocytes
#9
Yu Hsu, Ryo Okada, Takashi Nishimura, Norihito Kawasaki, Kazuo Yamamoto, Naoki Matsumoto
Dendritic cell inhibitory receptor 3 (DCIR3) is a member of dendritic immuno-receptor family, of which protein expression has been unknown. We established a specific monoclonal antibody against mouse DCIR3 and investigated the expression of DCIR3 on immune cells of various immune organs. We found that DCIR3 was expressed on monocytes, but not on eosinophils and neutrophils. We also found the existence of a dichotomy in the levels of the expression of DCIR3 on monocytes in bone marrow, blood and spleen. Further investigation of the expression of several cell surface markers on DCIR3(High) cells and DCIR3(Low) cells revealed that DCIR3(High) cells were Ly-6C(-) CD43(High) CD11c(+) CD80(+) NK1...
October 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28993702/erv1-overexpression-in-myeloid-cells-protects-against-high-fat-diet-induced-obesity-and-glucose-intolerance
#10
Corneliu Sima, Eduardo Montero, Daniel Nguyen, Marcelo Freire, Paul Norris, Charles N Serhan, Thomas E Van Dyke
Non-resolving inflammation is a central pathologic component of obesity, insulin resistance, type 2 diabetes and associated morbidities. The resultant hyperglycemia is deleterious to the normal function of many organs and its control significantly improves survival and quality of life for patients with diabetes. Macrophages play critical roles in both onset and progression of obesity-associated insulin resistance. Here we show that systemic activation of inflammation resolution prevents from morbid obesity and hyperglycemia under dietary overload conditions...
October 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28969686/s100a8-a9-increases-the-mobilization-of-pro-inflammatory-ly6c-high-monocytes-to-the-synovium-during-experimental-osteoarthritis
#11
Niels A J Cremers, Martijn H J van den Bosch, Stephanie van Dalen, Irene Di Ceglie, Giuliana Ascone, Fons van de Loo, Marije Koenders, Peter van der Kraan, Annet Sloetjes, Thomas Vogl, Johannes Roth, Edwin J W Geven, Arjen B Blom, Peter L E M van Lent
BACKGROUND: Monocytes are dominant cells present within the inflamed synovium during osteoarthritis (OA). In mice, two functionally distinct monocyte subsets are described: pro-inflammatory Ly6C(high) and patrolling Ly6C(low) monocytes. Alarmins S100A8/A9 locally released by the synovium during inflammatory OA for prolonged periods may be dominant proteins involved in stimulating recruitment of Ly6C(high) monocytes from the circulation to the joint. Our objective was to investigate the role of S100A8/A9 in the mobilization of Ly6C(high) and Ly6C(low) monocytic populations to the inflamed joint in collagenase-induced OA (CiOA)...
September 29, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28935758/scavenger-receptor-cd36-directs-nonclassical-monocyte-patrolling-along-the-endothelium-during-early-atherogenesis
#12
Paola M Marcovecchio, Graham D Thomas, Zbigniew Mikulski, Erik Ehinger, Karin A L Mueller, Amy Blatchley, Runpei Wu, Yury I Miller, Anh Tram Nguyen, Angela M Taylor, Coleen A McNamara, Klaus Ley, Catherine C Hedrick
OBJECTIVE: Nonclassical monocytes (NCM) function to maintain vascular homeostasis by crawling or patrolling along the vessel wall. This subset of monocytes responds to viruses, tumor cells, and other pathogens to aid in protection of the host. In this study, we wished to determine how early atherogenesis impacts NCM patrolling in the vasculature. APPROACH AND RESULTS: To study the role of NCM in early atherogenesis, we quantified the patrolling behaviors of NCM in ApoE(-/-) (apolipoprotein E) and C57BL/6J mice fed a Western diet...
November 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28933216/dexamethasone-attenuates-the-enhanced-rewarding-effects-of-cocaine-following-experimental-traumatic-brain-injury
#13
Steven F Merkel, Allison M Andrews, Evan M Lutton, Roshanak Razmpour, Lee Anne Cannella, Servio H Ramirez
Clinical studies have identified traumatic brain injury (TBI) as a risk factor for the development of cocaine dependence. This claim is supported by our recent preclinical studies showing enhancement of the rewarding effects of cocaine in mice sustaining moderate controlled cortical impact (CCI) injury during adolescence. Here we test the efficacy of dexamethasone, an anti-inflammatory corticosteroid, to attenuate augmentation of the behavioral response to cocaine observed in CCI-TBI animals using the conditioned place preference (CPP) assay...
July 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28912781/microrna-dynamic-regulators-of-macrophage-polarization-and-plasticity
#14
REVIEW
Jezrom Bokcaerin Self-Fordham, Afsar Raza Naqvi, Juhi Raju Uttamani, Varun Kulkarni, Salvador Nares
The ability of a healthy immune system to clear the plethora of antigens it encounters incessantly relies on the enormous plasticity displayed by the comprising cell types. Macrophages (MΦs) are crucial member of the mononuclear phagocyte system (MPS) that constantly patrol the peripheral tissues and are actively recruited to the sites of injury and infection. In tissues, infiltrating monocytes replenish MΦ. Under the guidance of the local micro-milieu, MΦ can be activated to acquire specialized functional phenotypes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28834747/triggering-of-nod2-receptor-converts-inflammatory-ly6c-high-into-ly6c-low-monocytes-with-patrolling-properties
#15
Anne-Julie Lessard, Manon LeBel, Benoit Egarnes, Paul Préfontaine, Peter Thériault, Arnaud Droit, Alexandre Brunet, Serge Rivest, Jean Gosselin
The signals that regulate the fate of circulating monocytes remain unknown. In the present study, we demonstrate that triggering of the NOD2 receptor by muramyl dipeptide (MDP) converts inflammatory Ly6C(high) monocytes into patrolling Ly6C(low) monocytes. Administration of MDP to Nr4a1(-/-) mice, which lack Ly6C(low) monocytes, or to Ly6C(low)-depleted mice led to the emergence of blood-patrolling monocytes with a profile similar to that of Ly6C(low) monocytes, including high expression of CX3CR1 and LFA1...
August 22, 2017: Cell Reports
https://www.readbyqxmd.com/read/28811289/primary-tumors-limit-metastasis-formation-through-induction-of-il15-mediated-crosstalk-between-patrolling-monocytes-and-nk-cells
#16
Hiroshi Kubo, Sofia Mensurado, Natacha Goncalves-Sousa, Karine Serre, Bruno Silva-Santos
Metastases are responsible for the vast majority of cancer-related deaths. Although tumor cells can become invasive early during cancer progression, metastases formation typically occurs as a late event. How the immune response to primary tumors may dictate this outcome remains poorly understood, which hampers our capacity to manipulate it therapeutically. Here we used a two-step experimental model, based on the highly aggressive B16F10 melanoma, that temporally segregates the establishment of primary tumors (subcutaneously) and the formation of lung metastases (from intravenous injection)...
August 15, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28650342/inflammatory-ly6chi-monocytes-and-their-conversion-to-m2-macrophages-drive-atherosclerosis-regression
#17
Karishma Rahman, Yuliya Vengrenyuk, Stephen A Ramsey, Noemi Rotllan Vila, Natasha M Girgis, Jianhua Liu, Viktoria Gusarova, Jesper Gromada, Ada Weinstock, Kathryn J Moore, P'ng Loke, Edward A Fisher
Atherosclerosis is a chronic inflammatory disease, and developing therapies to promote its regression is an important clinical goal. We previously established that atherosclerosis regression is characterized by an overall decrease in plaque macrophages and enrichment in markers of alternatively activated M2 macrophages. We have now investigated the origin and functional requirement for M2 macrophages in regression in normolipidemic mice that received transplants of atherosclerotic aortic segments. We compared plaque regression in WT normolipidemic recipients and those deficient in chemokine receptors necessary to recruit inflammatory Ly6Chi (Ccr2-/- or Cx3cr1-/-) or patrolling Ly6Clo (Ccr5-/-) monocytes...
August 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28615357/donor-pulmonary-intravascular-nonclassical-monocytes-recruit-recipient-neutrophils-and-mediate-primary-lung-allograft-dysfunction
#18
Zhikun Zheng, Stephen Chiu, Mahzad Akbarpour, Haiying Sun, Paul A Reyfman, Kishore R Anekalla, Hiam Abdala-Valencia, Daphne Edgren, Wenjun Li, Daniel Kreisel, Farida V Korobova, Ramiro Fernandez, Alexandra McQuattie-Pimentel, Zheng J Zhang, Harris Perlman, Alexander V Misharin, G R Scott Budinger, Ankit Bharat
Primary graft dysfunction is the predominant driver of mortality and graft loss after lung transplantation. Recruitment of neutrophils as a result of ischemia-reperfusion injury is thought to cause primary graft dysfunction; however, the mechanisms that regulate neutrophil influx into the injured lung are incompletely understood. We found that donor-derived intravascular nonclassical monocytes (NCMs) are retained in human and murine donor lungs used in transplantation and can be visualized at sites of endothelial injury after reperfusion...
June 14, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28586340/patrolling-monocytes-sense-peripheral-infection-and-induce-cytokine-mediated-neuronal-dysfunction
#19
Josef Priller, Chotima Böttcher
No abstract text is available yet for this article.
June 6, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28566450/monocyte-subtypes-and-the-ccr2-chemokine-receptor-in-cardiovascular-disease
#20
REVIEW
Carolina N França, Maria C O Izar, Marinella N S Hortêncio, Jônatas B do Amaral, Carlos E S Ferreira, Izabela D Tuleta, Francisco A H Fonseca
Monocytes circulate in the blood and migrate to inflammatory tissues, but their functions can be either detrimental or beneficial, depending on their phenotypes. In humans, classical monocytes are inflammatory cluster of differentiation (CD)14(++)CD16(-)CCR2(++) cells originated from the bone marrow or spleen reservoirs and comprise ≥92% of monocytes. Intermediate monocytes (CD14(++)CD16(+)CCR2(+)) are involved in the production of anti-inflammatory cytokines [such as interleukin (IL)-10], reactive oxygen species (ROS), and proinflammatory mediators [such as tumor necrosis factor-α (TNF-α) and IL-1β)...
June 1, 2017: Clinical Science (1979-)
keyword
keyword
98088
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"