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patrolling monocytes

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https://www.readbyqxmd.com/read/29625610/a-novel-interaction-between-cx-3-cr-1-and-ccr-2-signalling-in-monocytes-constitutes-an-underlying-mechanism-for-persistent-vincristine-induced-pain
#1
Karli Montague, Raffaele Simeoli, Joao Valente, Marzia Malcangio
BACKGROUND: A dose-limiting side effect of chemotherapeutic agents such as vincristine (VCR) is neuropathic pain, which is poorly managed at present. Chemokine-mediated immune cell/neuron communication in preclinical VCR-induced pain forms an intriguing basis for the development of analgesics. In a murine VCR model, CX3 CR1 receptor-mediated signalling in monocytes/macrophages in the sciatic nerve orchestrates the development of mechanical hypersensitivity (allodynia). CX3 CR1 -deficient mice however still develop allodynia, albeit delayed; thus, additional underlying mechanisms emerge as VCR accumulates...
April 6, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29548546/the-effects-of-monocytes-on-tumor-cell-extravasation-in-a-3d-vascularized-microfluidic-model
#2
A Boussommier-Calleja, Y Atiyas, K Haase, M Headley, C Lewis, R D Kamm
Metastasis is the leading cause of cancer-related deaths. Recent developments in cancer immunotherapy have shown exciting therapeutic promise for metastatic patients. While most therapies target T cells, other immune cells, such as monocytes, hold great promise for therapeutic intervention. In our study, we provide primary evidence of direct engagement between human monocytes and tumor cells in a 3D vascularized microfluidic model. We first characterize the novel application of our model to investigate and visualize at high resolution the evolution of monocytes as they migrate from the intravascular to the extravascular micro-environment...
March 5, 2018: Biomaterials
https://www.readbyqxmd.com/read/29547441/role-of-tlr4-asp299gly-polymorphism-in-the-development-of-cardiovascular-diseases-in-hiv-infected-patients
#3
Laura Tarancon-Diez, Rebeca S De Pablo-Bernal, José Luis Jiménez, Ana I Álvarez-Ríos, Miguel Genebat, Isaac Rosado-Sánchez, María-Ángeles Muñoz-Fernández, Ezequiel Ruiz-Mateos, Manuel Leal
OBJECTIVE: Cardiovascular diseases (CVDs) are one of the main causes of morbimortality in HIV-infected patients on suppressive antiretroviral therapy. The objective of this work was to evaluate the role of single nucleotide polymorphisms (SNPs) in lipopolysaccharide (LPS) Toll-like receptor 4 (TLR4) and CVDs occurrence in HIV-infected patients. Additionally, the functional consequences of carrying these SNPs were analyzed. METHODS: The association of TLR4 SNPs, Asp299Gly/Thr399Ile with CVDs occurrence was analyzed using multivariate logistic regression models...
March 15, 2018: AIDS
https://www.readbyqxmd.com/read/29500407/mt4-mmp-deficiency-increases-patrolling-monocyte-recruitment-to-early-lesions-and-accelerates-atherosclerosis
#4
Cristina Clemente, Cristina Rius, Laura Alonso-Herranz, Mara Martín-Alonso, Ángela Pollán, Emilio Camafeita, Fernando Martínez, Rubén A Mota, Vanessa Núñez, Cristina Rodríguez, Motoharu Seiki, José Martínez-González, Vicente Andrés, Mercedes Ricote, Alicia G Arroyo
Matrix metalloproteinases are involved in vascular remodeling. Little is known about their immune regulatory role in atherosclerosis. Here we show that mice deficient for MT4-MMP have increased adherence of macrophages to inflamed peritonea, and larger lipid deposits and macrophage burden in atherosclerotic plaques. We also demonstrate that MT4-MMP deficiency results in higher numbers of patrolling monocytes crawling and adhered to inflamed endothelia, and the accumulation of Mafb+ apoptosis inhibitor of macrophage (AIM)+ macrophages at incipient atherosclerotic lesions in mice...
March 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29499723/increases-in-inflammatory-and-cd14-dim-cd16-pos-cd45-pos-patrolling-monocytes-in-sepsis-correlation-with-final-outcome
#5
Gabriela Gainaru, Antonios Papadopoulos, Iraklis Tsangaris, Malvina Lada, Evangelos J Giamarellos-Bourboulis, Aikaterini Pistiki
BACKGROUND: Evidence on the changes in the absolute counts of monocyte subpopulations in sepsis is missing. METHODS: Firstly, absolute counts of circulating CD14pos /HLA-DRpos /CD45pos monocytes were measured by flow cytometry in 70 patients with Gram-negative sepsis and in 10 healthy volunteers. In the second phase, immunophenotyping was performed and the absolute count of circulating inflammatory monocytes and of circulating CD14dim /CD16pos /CD45pos patrolling monocytes were measured in another 55 patients and 10 healthy volunteers...
March 3, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29467472/effector-cd4-t-cells-recognize-intravascular-antigen-presented-by-patrolling-monocytes
#6
Clare L V Westhorpe, M Ursula Norman, Pam Hall, Sarah L Snelgrove, Michaela Finsterbusch, Anqi Li, Camden Lo, Zhe Hao Tan, Songhui Li, Susan K Nilsson, A Richard Kitching, Michael J Hickey
Although effector CD4+ T cells readily respond to antigen outside the vasculature, how they respond to intravascular antigens is unknown. Here we show the process of intravascular antigen recognition using intravital multiphoton microscopy of glomeruli. CD4+ T cells undergo intravascular migration within uninflamed glomeruli. Similarly, while MHCII is not expressed by intrinsic glomerular cells, intravascular MHCII-expressing immune cells patrol glomerular capillaries, interacting with CD4+ T cells. Following intravascular deposition of antigen in glomeruli, effector CD4+ T-cell responses, including NFAT1 nuclear translocation and decreased migration, are consistent with antigen recognition...
February 21, 2018: Nature Communications
https://www.readbyqxmd.com/read/29445379/contribution-of-regulatory-t-cells-in-nucleotide-binding-oligomerization-domain-2-response-to-influenza-virus-infection
#7
Benoit Egarnes, Jean Gosselin
Influenza A virus (IAV) is recognized to cause severe pulmonary illnesses in humans, particularly in elderly and children. One of the features associated with IAV infection is an excessive lung inflammation due to an uncontrolled immune response. The nucleotide-binding oligomerization domain 2 (NOD2) receptor is known to recognize ssRNA viruses such as IAV, but its role in the inflammatory process during viral infections remains to be clarified. In a previous report, we have shown that activation of NOD2 with muramyl dipeptide (MDP) significantly reduces both viral loads and lung inflammation and also improves pulmonary function during IAV infection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29440458/macrophage-targeting-fasudil-treatment-protects-liver-from-the-ischemia-reperfusion-injury-by-promoting-m2-macrophage-polarization
#8
Yingli Xie, Di Zhao, Pingshuan Dong, Lihong Lai
Macrophages play essential roles in the generation and resolution of inflammation. Ischemia-reperfusion injury (IRI) triggers a systemic inflammatory response and leads to cellular injury and organ failure. During surgical procedures of the liver, such as hepatic resection and liver transplantation, IRI leads to the dysfunction of the liver. Rho-associated protein kinase (ROCK) inhibitors were reported protecting the liver from IRI. However, the systematic administration of ROCK inhibitors causes severe hypotension...
February 12, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29367702/angiogenic-factor-driven-inflammation-promotes-extravasation-of-human-proangiogenic-monocytes-to-tumours
#9
Adama Sidibe, Patricia Ropraz, Stéphane Jemelin, Yalin Emre, Marine Poittevin, Marc Pocard, Paul F Bradfield, Beat A Imhof
Recruitment of circulating monocytes is critical for tumour angiogenesis. However, how human monocyte subpopulations extravasate to tumours is unclear. Here we show mechanisms of extravasation of human CD14dimCD16+ patrolling and CD14+CD16+ intermediate proangiogenic monocytes (HPMo), using human tumour xenograft models and live imaging of transmigration. IFNγ promotes an increase of the chemokine CX3CL1 on vessel lumen, imposing continuous crawling to HPMo and making these monocytes insensitive to chemokines required for their extravasation...
January 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29290545/immune-regulation-by-monocytes
#10
REVIEW
Peter J Murray
Monocytes emerging from the bone marrow are the progenitors of monocyte-derived macrophages. An essential function of monocytes is to seed tissues with sufficient macrophages to replace loss from infection and tissue damage. Recent work from diverse inflammatory and homeostatic settings has shown monocytes also possess direct protective and pathogenic activities. Thus, monocytes are not simply needed to generate macrophages, but instead contribute to the overall orchestration of immunity. Some recently described properties of monocytes are both surprising and mechanistically specific; for example, inflammatory monocytes are required for the efficacy of transferred activated cytotoxic T cells, but can have potent tissue damaging effects while patrolling monocytes are required for anti-tumor immunity in some cases, but in another example provokes resistance to chemotherapy and thereby aid tumor growth...
February 2018: Seminars in Immunology
https://www.readbyqxmd.com/read/29194752/the-regulatory-role-of-the-oral-commensal-streptococcus-mitis-on-human-monocytes
#11
S A Engen, O Schreurs, F Petersen, I J S Blix, E S Baekkevold, K Schenck
Streptococcus mitis colonizes all niches of the human oral cavity from early infancy and throughout life. Monocytes patrol blood vessels, lymphoid and non-lymphoid tissues and migrate into infected tissue where they participate in the inflammatory cascade and immune regulation. Here, we studied the effect of S. mitis on monocytes. Transcriptome analysis of monocytes exposed to S. mitis (SmMo) revealed increased transcription of chemotactic factors (CCL2, CCL3, CCL20, CXCL1, CXCL2) and cytokines (IL1A, IL1B, IL6, IL23, IL36G, TNF), indicating that S...
February 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29105655/pre-metastatic-cancer-exosomes-induce-immune-surveillance-by-patrolling-monocytes-at-the-metastatic-niche
#12
Michael P Plebanek, Nicholas L Angeloni, Elena Vinokour, Jia Li, Anna Henkin, Dalia Martinez-Marin, Stephanie Filleur, Reshma Bhowmick, Jack Henkin, Stephen D Miller, Igal Ifergan, Yesung Lee, Iman Osman, C Shad Thaxton, Olga V Volpert
Metastatic cancers produce exosomes that condition pre-metastatic niches in remote microenvironments to favor metastasis. In contrast, here we show that exosomes from poorly metastatic melanoma cells can potently inhibit metastasis to the lung. These "non-metastatic" exosomes stimulate an innate immune response through the expansion of Ly6Clow patrolling monocytes (PMo) in the bone marrow, which then cause cancer cell clearance at the pre-metastatic niche, via the recruitment of NK cells and TRAIL-dependent killing of melanoma cells by macrophages...
November 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/29045904/inkt-cells-orchestrate-a-switch-from-inflammation-to-resolution-of-sterile-liver-injury
#13
Pei Xiong Liew, Woo-Yong Lee, Paul Kubes
After traumatic injury, some cells function as detectors to sense injury and to modulate the local immune response toward a restitution phase by affecting the local cytokine milieu. Using intravital microscopy, we observed that patrolling invariant natural killer T (iNKT) cells were initially excluded from a site of hepatic injury but subsequently were strategically arrested first via self-antigens and then by cytokines, circumscribing the injured site at exactly the location where monocytes co-localized and hepatocytes proliferated...
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29042196/dcir3-and-dcir4-are-co-expressed-on-inflammatory-and-patrolling-monocytes
#14
Yu Hsu, Ryo Okada, Takashi Nishimura, Norihito Kawasaki, Kazuo Yamamoto, Naoki Matsumoto
Dendritic cell inhibitory receptor 3 (DCIR3) is a member of dendritic immuno-receptor family, of which protein expression has been unknown. We established a specific monoclonal antibody against mouse DCIR3 and investigated the expression of DCIR3 on immune cells of various immune organs. We found that DCIR3 was expressed on monocytes, but not on eosinophils and neutrophils. We also found the existence of a dichotomy in the levels of the expression of DCIR3 on monocytes in bone marrow, blood and spleen. Further investigation of the expression of several cell surface markers on DCIR3High cells and DCIR3Low cells revealed that DCIR3High cells were Ly-6C- CD43High CD11c+ CD80+ NK1...
December 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28993702/erv1-overexpression-in-myeloid-cells-protects-against-high-fat-diet-induced-obesity-and-glucose-intolerance
#15
Corneliu Sima, Eduardo Montero, Daniel Nguyen, Marcelo Freire, Paul Norris, Charles N Serhan, Thomas E Van Dyke
Non-resolving inflammation is a central pathologic component of obesity, insulin resistance, type 2 diabetes and associated morbidities. The resultant hyperglycemia is deleterious to the normal function of many organs and its control significantly improves survival and quality of life for patients with diabetes. Macrophages play critical roles in both onset and progression of obesity-associated insulin resistance. Here we show that systemic activation of inflammation resolution prevents from morbid obesity and hyperglycemia under dietary overload conditions...
October 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28969686/s100a8-a9-increases-the-mobilization-of-pro-inflammatory-ly6c-high-monocytes-to-the-synovium-during-experimental-osteoarthritis
#16
Niels A J Cremers, Martijn H J van den Bosch, Stephanie van Dalen, Irene Di Ceglie, Giuliana Ascone, Fons van de Loo, Marije Koenders, Peter van der Kraan, Annet Sloetjes, Thomas Vogl, Johannes Roth, Edwin J W Geven, Arjen B Blom, Peter L E M van Lent
BACKGROUND: Monocytes are dominant cells present within the inflamed synovium during osteoarthritis (OA). In mice, two functionally distinct monocyte subsets are described: pro-inflammatory Ly6C(high) and patrolling Ly6C(low) monocytes. Alarmins S100A8/A9 locally released by the synovium during inflammatory OA for prolonged periods may be dominant proteins involved in stimulating recruitment of Ly6C(high) monocytes from the circulation to the joint. Our objective was to investigate the role of S100A8/A9 in the mobilization of Ly6C(high) and Ly6C(low) monocytic populations to the inflamed joint in collagenase-induced OA (CiOA)...
September 29, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28935758/scavenger-receptor-cd36-directs-nonclassical-monocyte-patrolling-along-the-endothelium-during-early-atherogenesis
#17
Paola M Marcovecchio, Graham D Thomas, Zbigniew Mikulski, Erik Ehinger, Karin A L Mueller, Amy Blatchley, Runpei Wu, Yury I Miller, Anh Tram Nguyen, Angela M Taylor, Coleen A McNamara, Klaus Ley, Catherine C Hedrick
OBJECTIVE: Nonclassical monocytes (NCM) function to maintain vascular homeostasis by crawling or patrolling along the vessel wall. This subset of monocytes responds to viruses, tumor cells, and other pathogens to aid in protection of the host. In this study, we wished to determine how early atherogenesis impacts NCM patrolling in the vasculature. APPROACH AND RESULTS: To study the role of NCM in early atherogenesis, we quantified the patrolling behaviors of NCM in ApoE(-/-) (apolipoprotein E) and C57BL/6J mice fed a Western diet...
November 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28933216/dexamethasone-attenuates-the-enhanced-rewarding-effects-of-cocaine-following-experimental-traumatic-brain-injury
#18
Steven F Merkel, Allison M Andrews, Evan M Lutton, Roshanak Razmpour, Lee Anne Cannella, Servio H Ramirez
Clinical studies have identified traumatic brain injury (TBI) as a risk factor for the development of cocaine dependence. This claim is supported by our recent preclinical studies showing enhancement of the rewarding effects of cocaine in mice sustaining moderate controlled cortical impact (CCI) injury during adolescence. Here we test the efficacy of dexamethasone, an anti-inflammatory corticosteroid, to attenuate augmentation of the behavioral response to cocaine observed in CCI-TBI animals using the conditioned place preference (CPP) assay...
July 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28912781/microrna-dynamic-regulators-of-macrophage-polarization-and-plasticity
#19
REVIEW
Jezrom Bokcaerin Self-Fordham, Afsar Raza Naqvi, Juhi Raju Uttamani, Varun Kulkarni, Salvador Nares
The ability of a healthy immune system to clear the plethora of antigens it encounters incessantly relies on the enormous plasticity displayed by the comprising cell types. Macrophages (MΦs) are crucial member of the mononuclear phagocyte system (MPS) that constantly patrol the peripheral tissues and are actively recruited to the sites of injury and infection. In tissues, infiltrating monocytes replenish MΦ. Under the guidance of the local micro-milieu, MΦ can be activated to acquire specialized functional phenotypes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28834747/triggering-of-nod2-receptor-converts-inflammatory-ly6c-high-into-ly6c-low-monocytes-with-patrolling-properties
#20
Anne-Julie Lessard, Manon LeBel, Benoit Egarnes, Paul Préfontaine, Peter Thériault, Arnaud Droit, Alexandre Brunet, Serge Rivest, Jean Gosselin
The signals that regulate the fate of circulating monocytes remain unknown. In the present study, we demonstrate that triggering of the NOD2 receptor by muramyl dipeptide (MDP) converts inflammatory Ly6C(high) monocytes into patrolling Ly6C(low) monocytes. Administration of MDP to Nr4a1(-/-) mice, which lack Ly6C(low) monocytes, or to Ly6C(low)-depleted mice led to the emergence of blood-patrolling monocytes with a profile similar to that of Ly6C(low) monocytes, including high expression of CX3CR1 and LFA1...
August 22, 2017: Cell Reports
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