Leonie F Becker, Sinem Tunc, Peter Murphy, Tobias Bäumer, Anne Weissbach, Martje G Pauly, Duha M Al-Shorafat, Gerard Saranza, Anthony E Lang, Christian Beste, Tobias H Donner, Julius Verrel, Alexander Münchau
Dopa-responsive dystonia (DRD) is caused by an impaired dopamine biosynthesis due to a GTP-cyclohydrolase-1 (GCH1) deficiency, resulting in a combination of dystonia and parkinsonism. However, the effect of GCH1 mutations and levodopa treatment on motor control beyond simple movements, such as timing, action preparation and feedback processing, have not been investigated so far. In an active time estimation task with trial-by-trial feedback, participants indicated a target interval (1200 ms) by a motor response...
August 22, 2022: Scientific Reports