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Necrotizing pancreatitis

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https://www.readbyqxmd.com/read/27920530/blockage-of-both-the-extrinsic-and-intrinsic-pathways-of-diazinon-induced-apoptosis-in-patu-cells-by-magnesium-oxide-and-selenium-nanoparticles
#1
Mahdi Shiri, Mona Navaei-Nigjeh, Maryam Baeeri, Mahban Rahimifard, Hossein Mahboudi, Ahmad Reza Shahverdi, Abbas Kebriaeezadeh, Mohammad Abdollahi
Diazinon (DZ) is an organophosphorus insecticide that acts as an acetylcholinesterase inhibitor. It is important to note that it can induce oxidative stress, lipid peroxidation, diabetic disorders, and cytotoxicity. Magnesium oxide (MgO) and selenium nanoparticles (Se NPs) showed promising protection against oxidative stress, lipid peroxidation, cytotoxicity, and diabetic disorders. Therefore, this study was conducted to explore the possible protective mechanisms of MgO and Se NPs against DZ-induced cytotoxicity in PaTu cell line...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27920277/the%C3%A2-diffuse%C3%A2-reduction%C3%A2-of%C3%A2-spleen%C3%A2-density-%C3%A2-an%C3%A2-indicator%C3%A2-of%C3%A2-severe%C3%A2-acute%C3%A2-pancreatitis
#2
Guangdong Shao, Yanmei Zhou, Zengfu Song, Maitao Jiang, Xiaoqian Wang, Xiangren Jin, Bei Sun, Xuewei Bai
BACKGROUND: We observed that acute pancreatitis (AP) was associated with diffuse reduction of spleen density (DROSD) in some patients. Furthermore, the condition of these patients was more serious, and the potential relationship between DROSD and structural and functional injury of the spleen remained unclear. Therefore, we performed a preliminary exploration of these factors. METHODS: We analysed pertinent clinical data for AP patients with normal spleen density (control group) and for those with DROSD (reduction group) at the First Affiliated Hospital of Harbin Medical University (2013...
December 5, 2016: Bioscience Reports
https://www.readbyqxmd.com/read/27900090/traumatic-rupture-of-solid-pseudopapillary-tumors-of-the-pancreas-in-children-a-case-report
#3
Semih Lütfi Mirapoğlu, Ibrahim Aydogdu, Zuhal Gucin, Temel Fatih Yilmaz, Tarik Umutoglu, Huseyin Kilincaslan
Solid pseudopapillary tumor (SPT) of the pancreas is a pathological entity rarely encountered in children. Despite its malignant characteristics, SPT has a favorable clinical prognosis. This tumor is more frequently observed in females and is commonly localized in the tail and body of the pancreas. This is the case report of a 9-year-old female patient who presented with severe abdominal pain of sudden onset and vomiting following blunt abdominal trauma. Upon physical examination, abdominal distension, tenderness and abdominal guarding were detected...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27899271/the-role-of-transpapillary-drainage-in-management-of-patients-with-pancreatic-fluid-collections-and-pancreatic-duct-disruption-as-a-consequences-of-severe-acute-pancreatitis
#4
EDITORIAL
Mateusz Jagielski, Marian Smoczyński, Krystian Adrych
In last thirty years we have been observing significant development of an endoscopic treatment of pancreatic fluid collections, including transmural drainage of walled-off pancreatic necrosis. Simultaneously, the use of endotherapy in treatment of main pancreatic ducts disruptions has increased. Despite many publications available in current literature, concerning the endoscopic treatment of consequences of acute necrotizing pancreatitis, the role of transpapillary drainage in management of patients with pancreatic fluid collections and pancreatic duct disruption as an after-effect of severe acute pancreatitis remains unclear and is still a current problem...
November 18, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27895456/acute-necrotizing-pancreatitis-after-chemoembolization-for-hepatocellular
#5
S Soulaidopoulos, P Chalevas, E Cholongitas
No abstract text is available yet for this article.
January 2016: Hippokratia
https://www.readbyqxmd.com/read/27891150/splenic-artery-embolization-for-the-treatment-of-gastric-variceal-bleeding-secondary-to-splenic-vein-thrombosis-complicated-by-necrotizing-pancreatitis-report-of-a-case
#6
Hee Joon Kim, Eun Kyu Park, Young Hoe Hur, Yang Seok Koh, Chol Kyoon Cho
Splenic vein thrombosis is a relatively common finding in pancreatitis. Gastric variceal bleeding is a life-threatening complication of splenic vein thrombosis, resulting from increased blood flow to short gastric vein. Traditionally, splenectomy is considered the treatment of choice. However, surgery in necrotizing pancreatitis is dangerous, because of severe inflammation, adhesion, and bleeding tendency. In the Warshaw operation, gastric variceal bleeding is rare, even though splenic vein is resected. Because the splenic artery is also resected, blood flow to short gastric vein is not increased problematically...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27878276/expression-pattern-of-hmgb1-and-its-association-with-autophagy-in-acute-necrotizing-pancreatitis
#7
Can Yu, Xiao Yu, Hong-Wei Zhu, Xia Li, Li-Hua Huang, Zhi-Qiang Li, Duo Han, Hui Huang
High-motility group box protein 1 (HMGB1) has an important role in autophagy; however, its exact role in acute necrotizing pancreatitis (ANP) remains unknown. The present study aimed to investigate the expression pattern of HMGB1 in ANP, and to determine its association with autophagy. Sprague Dawley rats (weight, 350±30 g, n=48) were randomly divided into control (n=12) and experimental (n=36) groups. Experimental rats were retrogradely injected with 5% sodium taurocholate into the biliopancreatic duct to induce ANP...
November 15, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27853829/-hepatopancreaticobiliary-diseases-in-igg4-associated-autoimmune-diseases
#8
L Grenacher
BACKGROUND: IgG4-related diseases are rare systemic multiorgan diseases and can thus affect any organ system. The incidence of diagnosis has significantly increased due to increasing awareness. OBJECTIVE: In the abdomen the hepatopancreaticobiliary system provides an essential organ system for the expression of IgG4-associated autoimmune diseases. The focus here is autoimmune pancreatitis type 1 but IgG4-associated sclerosing cholangitis and IgG4-associated hepatopathy, which can also occur in combination are less well-known...
November 16, 2016: Der Radiologe
https://www.readbyqxmd.com/read/27853493/implantability-complications-and-follow-up-after-transjugular-intrahepatic-portosystemic-stent-shunt-creation-with-the-6f-self-expanding-sinus-superflex-visual-stent
#9
Daniel Spira, Jakub Wiskirchen, Ulrich Lauer, Dominik Ketelsen, Konstantin Nikolaou, Benjamin Wiesinger
BACKGROUND: The transjugular intrahepatic portosystemic stent-shunt (TIPSS) builds a shortcut between the portal vein and a liver vein, and represents a sophisticated alternative to open surgery in the management of portal hypertension or its complications. OBJECTIVES: To describe clinical experiences with a low-profile nitinol stent system in TIPSS creation, and to assess primary and long-term success. PATIENTS AND METHODS: Twenty-six patients (5 females, 21 males; mean age 54...
July 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27832819/negative-pressure-irrigation-and-endoscopic-necrosectomy-through-man-made-sinus-tract-in-infected-necrotizing-pancreatitis-a-technical-report
#10
Zhihui Tong, Lu Ke, Baiqiang Li, Gang Li, Jing Zhou, Xiao Shen, Weiqin Li, Ning Li, Jieshou Li
BACKGROUND: In recent years, a step-up approach based on minimally invasive techniques was recommended by latest guidelines as initial invasive treatment for infected pancreatic necrosis (IPN). In this study, we aimed to describe a novel step-up approach for treating IPN consisting of four steps including negative pressure irrigation (NPI) and endoscopic necrosectomy (ED) as a bridge between percutaneous catheter drainage (PCD) and open necrosectomy METHODS: A retrospective review of a prospectively collected internal database of patients with a diagnosis of IPN between Jan, 2012 to Dec, 2012 at a single institution was performed...
November 10, 2016: BMC Surgery
https://www.readbyqxmd.com/read/27830885/the-protective-role-of-melatonin-on-l-arginine-induced-acute-pancreatitis-in-adult-male-albino-rats
#11
Ahmed S Sadek, Rehab T Khattab
BACKGROUND: Acute pancreatitis (AP) is an inflammatory disease that has an increasing incidence worldwide. It is associated with high morbidity and mortality rates ranging from 15-40% in its severe form. Oxidative stress plays an important role in pancreatic acinar cell injury in case of AP. Melatonin is proven to have both antioxidant and anti-inflammatory effects. The aim of the work was to investigate the protective role of melatonin (Mel) against L-arginine (L-arg)-induced AP in adult male albino rats...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27826206/necrotizing-pancreatitis-challenges-and-solutions
#12
REVIEW
Victoria A Bendersky, Mohan K Mallipeddi, Alexander Perez, Theodore N Pappas
Acute pancreatitis is a common disease that can progress to gland necrosis, which imposes significant risk of morbidity and mortality. In general, the treatment for pancreatitis is a supportive therapy. However, there are several reasons to escalate to surgery or another intervention. This review discusses the pathophysiology as well as medical and interventional management of necrotizing pancreatitis. Current evidence suggests that patients are best served by delaying interventions for at least 4 weeks, draining as a first resort, and debriding recalcitrant tissue using minimally invasive techniques to promote or enhance postoperative recovery while reducing wound-related complications...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27807566/olanzapine-induced-hypertriglyceridemia-resulting-in-necrotizing-pancreatitis
#13
Samantha M Buszek, Prabir Roy-Chaudhury, Ganesh Yadlapalli
Olanzapine is an atypical antipsychotic agent that was approved by the Food and Drug Administration in 1996 for treatment of psychotic disorders, bipolar disorder, and schizophrenia. Since that time, numerous case reports have been published that describe the association of olanzapine and the development of pancreatitis. Furthermore, 3 reports suggest the mechanism of olanzapine-induced hypertriglyceridemia as the etiology of this progression. We report a case of a 36-year-old man who developed necrotizing pancreatitis secondary to olanzapine-induced hypertriglyceridemia...
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27806778/-experience-of-minimal-access-video-assisted-retroperitoneal-debridement-in-treatment-of-infected-pancreatic-necrosis
#14
J Feng, Z W Liu, S W Cai, H H Jiao, J D Du, X L Xin, J Y Chen, P F Wang, L He, S C Lu, Y Y Xiao, M Q Wang
Objective: To explore the experience of minimal-access video-assisted retroperitoneal debridement in treatment of infected pancreatic necrosis(IPN). Methods: A retrospective review was performed on 12 patients with IPN who underwent minimal-access video-assisted retroperitoneal debridement between June 2008 and June 2013 in People's Liberation Army General Hospital and First Affiliated Hospital of People's Liberation Army General Hospital, respectively.There were 10 male patients and 2 female patients aging from 33 to 55 years with mean age of(43±8)years...
November 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27805963/outcome-of-acute-pancreatic-and-peripancreatic-collections-occurring-in-patients-with-acute-pancreatitis
#15
Manish Manrai, Rakesh Kochhar, Vikas Gupta, Thakur Deen Yadav, Narendra Dhaka, Naveen Kalra, Saroj K Sinha, Niranjan Khandelwal
OBJECTIVE: To study the outcome of acute collections occurring in patients with acute pancreatitis BACKGROUND:: There are limited data on natural history of acute collections arising after acute pancreatitis (AP). METHODS: Consecutive patients of AP admitted between July 2011 and December 2012 were evaluated by imaging for development of acute collections as defined by revised Atlanta classification. Imaging was repeated at 1 and 3 months. Spontaneous resolution, evolution, and need for intervention were assessed...
November 1, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27798150/epigenetic-regulation-of-early-and-late-response-genes-in-acute-pancreatitis
#16
Juan Sandoval, Javier Pereda, Salvador Pérez, Isabela Finamor, Azahara Vallet-Sánchez, José Luis Rodríguez, Luis Franco, Juan Sastre, Gerardo López-Rodas
Chromatin remodeling seems to regulate the patterns of proinflammatory genes. Our aim was to provide new insights into the epigenetic mechanisms that control transcriptional activation of early- and late-response genes in initiation and development of severe acute pancreatitis as a model of acute inflammation. Chromatin changes were studied by chromatin immunoprecipitation analysis, nucleosome positioning, and determination of histone modifications in promoters of proinflammatory genes in vivo in the course of taurocholate-induced necrotizing pancreatitis in rats and in vitro in rat pancreatic AR42J acinar cells stimulated with taurocholate or TNF-α...
October 19, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27795463/histopathological-changes-in-the-pancreas-of-cattle-with-abdominal-fat-necrosis
#17
Chikako Tani, Watanyoo Pratakpiriya, Mineto Tani, Takenori Yamauchi, Takuya Hirai, Ryoji Yamaguchi, Hitoshi Ano, Hiromu Katamoto
The association between pancreatic disorder and abdominal fat necrosis in cattle remains unclear. The pancreases of 29 slaughtered cattle with or without fat necrosis were collected to investigate pathological changes. Japanese Black (JB) cattle were classified into the FN group (with abdominal fat necrosis; n=9) and N group (without fat necrosis; n=5). The pancreases were also collected from 15 Holstein Friesian (HF) cows. All JB cattle showed high body condition scores. Regarding the pathological findings, fatty pancreas which involves adipocyte infiltration into the pancreas and fat necrosis (saponification) were observed in 25 and 27 cases, respectively...
October 30, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27793575/unrecognized-necrosis-at-same-admission-cholecystectomy-for-pancreatitis-increases-organ-failure-and-infected-necrosis
#18
Wilson Tak-Yu Kwong, Santhi Swaroop Vege
BACKGROUND AND AIMS: Guidelines recommend same admission cholecystectomy (SAC) in the management of mild acute gallstone pancreatitis (AGP) with a recent randomized trial supporting this recommendation. However, the push for early cholecystectomy will lead a subset of patients with evolving, unrecognized necrotizing pancreatitis (NP) to undergo laparoscopic cholecystectomy (LC) with unknown consequences. With concerns about potentially serious outcomes, we studied the outcomes in patients with unrecognized NP who underwent SAC and identified predictors of unrecognized NP at the time of SAC...
October 21, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27793122/acute-pancreatitis-associated-with-everolimus-after-kidney-transplantation-a-case-report
#19
Francesco Fontana, Gianni Cappelli
BACKGROUND: Acute pancreatitis (AP) following KT is a rare and often fatal complication of the early post-transplant period. Common causative factors for AP are rare after KT; anti-rejection drugs as CyA, prednisone and MMF have been implicated, although evidence is not strong and we found no reports on possible causative role for mTOR inhibitors. CASE PRESENTATION: A 55-year-old Caucasian man with end-stage renal disease due to idiopathic membrano-prolipherative glomerulonephritis underwent single kidney transplantation (KT) from cadaveric donor...
October 28, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27779235/one-compound-of-saponins-from-disocorea-zingiberensis-protected-against-experimental-acute-pancreatitis-by-preventing-mitochondria-mediated-necrosis
#20
Rui Zhang, Li Wen, Yan Shen, Na Shi, Zhihua Xing, Qing Xia, Hai Niu, Wen Huang
Acute pancreatitis (AP) is a painful inflammatory disorder of the exocrine pancreas, ranking as the most common gastrointestinal reasons for hospitalization with no specific therapy currently. Diosgenyl saponins extracted from natural products and diosgenin or its derivatives have been shown to exert anti-inflammatory effects in various diseases. However, the therapeutic effects of diosgenyl saponins from Dioscorea zingiberensis C. H. Wright in AP have not yet been determined. Five compounds were extracted and screened for taurocholate-induced necrosis in mouse pancreatic acinar cells...
October 25, 2016: Scientific Reports
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