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renal autoinmune

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https://www.readbyqxmd.com/read/8864821/dysregulated-transforming-growth-factor-beta-in-neonatal-and-adult-autoimmune-mrl-lpr-mice
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B Kreft, H Yokoyama, T Naito, V R Kelley
Transforming growth factor- beta (TGF- beta) is a cytokine that promotes inflammatory processes and prevents tissue injury. Autoimmune destruction of the kidney in MRL-lpr mice is spontaneous, rapid, fatal and consists of glomerular damage and an influx of lymphocytes surrounding vessels and in the interstitium. In MRL-lpr mice, cytokine dysregulation is apparent in neonates and continues throughout the life span. Circulating levels of tumour necrosis factor (TNF- alpha) and colony stimulating factor-1 (CSF-1) are detected in neonatal mice and progressively increase in proportion to the loss of renal function...
August 1996: Journal of Autoimmunity
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