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https://www.readbyqxmd.com/read/29656434/evaluation-of-antioxidant-antiinflammatory-and-gastroprotective-properties-of-rubus-fruticosus-l-fruit-juice
#1
Maria Teresa Monforte, Antonella Smeriglio, Maria Paola Germanò, Simona Pergolizzi, Clara Circosta, Enza Maria Galati
The juice of R. fruticosus (RFJ) fruits grown in Sicily was analysed for polyphenol compounds and tested to evaluate in vitro antioxidant and in vivo antiinflammatory and gastroprotective effects. RFJ, containing mainly anthocyanins, such as cyanidin derivatives, significant amounts of phenolic acids, and smaller amounts of flavonoids, showed significant antioxidant activity in DPPH (2,2-diphenyl-1-picrylhydrazyl radical) (4,147.194 ± 17.199 mg trolox equivalent [TE]/100 ml), TE antioxidant capacity (8,312...
April 15, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29656315/acamprosate-protects-against-adjuvant-induced-arthritis-in-rats-via-blocking-the-erk-mapk-and-nf-%C3%AE%C2%BAb-signaling-pathway
#2
Jun Pan, Rilong Jin, Miaoda Shen, Ronghuan Wu, Sanzhong Xu
Osteoarthritis is a type of joint disease that results from the breakdown of joint cartilage and underlying bone and is believed to be caused by mechanical stress on the joint and low-grade inflammatory processes. Acamprosate significantly ameliorates the pathological features of experimental autoimmune encephalomyelitis due to its anti-inflammatory effect. The aims of the present study were to investigate the anti-arthritis activities of acamprosate and elucidate the underlying mechanisms. Adjuvant-induced arthritis (AIA) was induced by intradermal injection of complete Freund's adjuvant...
April 14, 2018: Inflammation
https://www.readbyqxmd.com/read/29656207/dihydromyricetin-relieves-rheumatoid-arthritis-symptoms-and-suppresses-expression-of-pro-inflammatory-cytokines-via-the-activation-of-nrf2-pathway-in-rheumatoid-arthritis-model
#3
Jianguo Chu, Xiujun Wang, Huanjie Bi, Lifeng Li, Mingguang Ren, Jingwei Wang
Rheumatoid arthritis (RA) is a systemic inflammatory and autoimmune disease. In this research, we estimated the protective effects of Dihydromyricetin (DMY) on RA induced by Complete Freund's Adjuvant (CFA). We found that DMY effectively relieved rheumatoid arthritis symptoms, such as body weight change, paw swelling and rheumatoid arthritis scores. In addition, we also observed that DMY significantly lowered the immune organ indexes (including thymus and spleen) and exhibited the anti-inflammatory effect in CFA-induced rheumatoid arthritis...
April 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29655928/effects-of-3-months-sitting-callisthenic-balance-and-resistance-exercise-on-aerobic-capacity-aortic-stiffness-and-body-composition-in-healthy-older-participants-randomized-controlled-trial
#4
Sławomir Kujawski, Agnieszka Kujawska, Małgorzata Gajos, Jacek J Klawe, Małgorzata Tafil-Klawe, Katarzyna Mądra-Gackowska, Błażej Stankiewicz, Julia L Newton, Kornelia Kędziora-Kornatowska, Paweł Zalewski
BACKGROUND: Arterial stiffness (AS) is a reduction in the ability of large arteries to readily accommodate the increase in blood ejected from the heart during systole related with aging. Physical exercise is associated with AS reduction. However, it remains controversial as to which modality and intensity (resistance vs aerobic, high vs low) would be the most effective. The aim of these studies is to examine the effects of 3-months sitting callisthenic balance (SCB) and resistance exercise (RET) on aerobic capacity, aortic stiffness and body composition in older participants...
April 12, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29655911/antinociceptive-activity-of-riparin-ii-from-aniba-riparia-further-elucidation-of-the-possible-mechanisms
#5
Alyne Mara Rodrigues de Carvalho, Leonardo Freire Vasconcelos, Nayrton Flávio Moura Rocha, Emiliano Ricardo Vasconcelos Rios, Marília Leite Dias, Marta Maria de França Fonteles, Danielle Macêdo Gaspar, José Maria Barbosa Filho, Stanley Juan Chavez Gutierrez, Francisca Cléa Florenço de Sousa
Riparin II (RipII) has an anti-inflammatory activity potentially due its ability to decrease TNF-α and IL-1β production and its histamine antagonism. The objective of this study was to evaluate the role of RipII in the pain process and the possible antinociceptive mechanisms involved, using classic models of nociception. Male Swiss mice were used in the assays. Determinate the acute toxicity according to the OECD 425 test guideline. The models used were the acetic acid-, formalin-, hot plate and glutamate-induced nociception...
April 12, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29655678/anti-inflammatory-and-antioxidant-activities-of-naringin-isolated-from-carissa-carandas-l-in-vitro-and-in-vivo-evidence
#6
Ahmed H El-Desoky, Rehab F Abdel-Rahman, Osama K Ahmed, Hossam S El-Beltagi, Masao Hattori
BACKGROUND: Carissa carandas L. is known in folk medicine for its anti-inflammatory and hepatoprotective activities. Meanwhile it is an evergreen shrub that constitutes a continuous source of leaves throughout the year. HYPOTHESIS/PURPOSE: The leaves of Carissa carandas L. may be rich in compounds that can be used as safe anti-inflammatory and antioxidant remedies. The combined antioxidant and anti-inflammatory activities provoked the study of the hepatoprotective effects...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29652427/the-network-of-invasive-cardiology-facilities-in-poland-in-2016-data-from-the-orpki-polish-national-registry
#7
Paweł Kleczyński, Zbigniew Siudak, Artur Dziewierz, Tomasz Tokarek, Tomasz Rakowski, Jacek Legutko, Stanislaw Bartuś, Dariusz Dudek
No abstract text is available yet for this article.
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29651969/synthesis-characterization-of-ethyl-5-substituted-1h-pyrazole-3-carboxylate-derivative-as-potent-anti-inflammatory-agents
#8
Sujeet Kumar Gupta, Pratik Khanal, Arun Kumar, Arun Kumar, Neha Srivastava, Bhumika Yogi, Anshuman Sinha
BACKGROUND: Recently, pyrazole derivatives have shown significant anti-inflammatory activity. Non-steroidal anti-inflammatory drugs have the drawbacks of such as gastric irritation and gastric ulceration in treatment of inflammation. So the current study deals with the synthesis and pharmacological evaluation of a series of novel pyrazole derivatives as anti-inflammatory agents. METHODS: A series of novel ethyl 5-(substituted)-1H-pyrazole-3-carboxylate (2a-j) were synthesized and evaluated for anti-inflammatory activity using carrageenan-induced inflammation in rat paw edema model...
April 11, 2018: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29651968/design-synthesis-characterization-qsar-anti-inflammatory-and-analgesic-evaluation-of-some-new-phthalazinediones
#9
Yousery E Sherif, Ryan A Ansary, Moustafa A Gouda
Interaction of dibenzobarallene 3 with thiosemicarbazides 4-8 afforded the Phthalazinediones 10-15. The structures of the newly synthesized compounds were confirmed on the basis of elemental analysis and spectral data. One equation was predicted using quantitative structure activity relationship (QSAR) and regression analysis for the anti-inflammatory activity with a regression correlation (R) close to unity. The anti-inflammatory activity and analgesic effect of the thioamides 10-15 were determined by collagen II-adjuvant induced paw edema test in rats...
April 12, 2018: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29651867/molecular-modelling-insights-into-a-physiologically-favourable-approach-to-eicosanoid-biosynthesis-inhibition-through-novel-thieno-2-3-b-pyridine-derivatives
#10
Mosaad S Mohamed, Yara E Mansour, Hatem K Amin, Moustafa E El-Araby
In this research, we exploited derivatives of thieno[2,3-b]pyridine as dual inhibitors of the key enzymes in eicosanoid biosynthesis, cyclooxygenase (COX, subtypes 1 and 2) and 5-lipoxygensase (5-LOX). Testing these compounds in a rat paw oedema model revealed potency higher than ibuprofen. The most active compounds 7a, 7b, 8b, and 8c were screened against COX-1/2 and 5-LOX enzymes. Compound 7a was the most powerful inhibitor of 5-LOX with IC50  = 0.15 µM, while its p-chloro analogue 7b was more active against COX-2 (IC50  = 7...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29650410/assessment-of-intersegmental-coordination-of-rats-during-walking-at-different-speeds-application-of-continuous-relative-phase
#11
Peter C Raffalt, Louise R Nielsen, Stefan Madsen, Laurits Munk Højberg, Jessica Pingel, Jens Bo Nielsen, Tine Alkjær, Jacob Wienecke
The present study investigated the feasibility and reliability of continuous relative phase (CRP) and deviation phase (DP) to assess intersegmental hind limb coordination pattern and coordination variability in rats during walking. Twenty-six adult rats walked at 8 m/min, 12 m/min and 16 m/min while two-dimensional kinematics were recorded. Segment angles and segment angular velocities of the paw, shank and thigh on the left hind-limb were extracted from 15 strides and CRP was calculated for the paw-shank and shank-thigh coupling...
April 4, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29650384/the-effect-of-combined-drugs-therapy-on-the-course-of-clinical-rabies-infection-in-a-murine-model
#12
Marcin Smreczak, Anna Orłowska, Anna Marzec, Paweł Trębas, Anna Kycko, Michał Reichert, Penelope Koraka, Albert D M E Osterhaus, Jan Franciszek Żmudziński
Rabies is a fatal disease of all mammals causing almost 60,000 human deaths every year. To date, there is no effective treatment of clinical rabies once the symptoms appear. Here, we describe the promising effect of combination therapy composed of molecules that target replication of the rabies virus (RV) at different stages of life cycle and molecules that inhibit some pathways of the innate host immune response accompanied by a blood-brain barrier opener on the outcome of RV infection. The study reports statistically significant extension of survival of mice treated with the drug cocktail containing T-705, ribavirin, interferon α/β, caspase-1 inhibitor, TNF-α inhibitor, MAPKs inhibitor and HRIG compared to the survival of mice in the virus control group (p = 0...
April 9, 2018: Vaccine
https://www.readbyqxmd.com/read/29649753/fragmentation-patterns-involving-ammonium-adduct-fragment-ions-a-comparison-of-the-determination-of-metaldehyde-in-human-blood-by-hplc-qqq-ms-ms-and-uhplc-q-tof-ms
#13
Paweł Szpot, Grzegorz Buszewicz, Tomasz Jurek, Grzegorz Teresiński
This paper presents a rapid, sensitive and precise method for the determination of metaldehyde in human blood, using ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry and high-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry. Separation was performed with a Poroshell 120 EC-C18 column; 2.7 μm atrazine‑d5 (IS) and 200 mg NaCl were added to the blood sample. Proteins in human blood were precipitated using acetonitrile; the supernatant was then analyzed with the UHPLC-Q-TOF-MS or HPLC-QqQ-MS/MS system...
March 8, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29649683/modulation-of-udp-glucuronidation-by-acridinone-antitumor-agents-c-1305-and-c-1311-in-hepg2-and-ht29-cell-lines-despite-slight-impact-in-noncellular-systems
#14
Anna Bejrowska, Monika Pawłowska, Anna Mróz, Zofia Mazerska
BACKGROUND: Among the studied antitumor acridinone derivatives developed in our laboratory, 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) and 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) exhibited cytotoxic and antitumor properties against several cancer types and were selected to be evaluated in preclinical and early-phase clinical trials. In the present work, we investigated the impact of C-1305 and C-1311 on UDP-glucuronosyltransferase (UGT) activity...
November 22, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29648984/facilitation-of-locomotor-spinal-networks-activity-by-buspirone-after-a-complete-spinal-cord-lesion-in-mice
#15
Renaud Jeffrey-Gauthier, Nicolas Josset, Frédéric Bretzner, Hugues Leblond
Despite efforts to potentiate spinal cord lesioned (SCL) patients' functional recovery with multi-targeted therapy combining pharmacological treatment and training, consistent improvements in locomotor control by descending transmission or spinal network facilitation are still eluding clinicians and researchers. Lately, US Food and Drug Administration-approved buspirone has shown promise and promoted locomotor-like movement occurrence in SCL patients, but evidence on how and where it exerts its effects is lacking...
March 16, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29643968/gastric-wall-thickness-and-stapling-in-laparoscopic-sleeve-gastrectomy-a-literature-review
#16
REVIEW
Krzysztof Barski, Artur Binda, Emilia Kudlicka, Paweł Jaworski, Wiesław Tarnowski
Despite the growing experience of bariatric surgeons in performing laparoscopic sleeve gastrectomy, the number of complications involving staple line leaks remains constant. Hence a solution to avoid such complications is still sought. A defect of the staple line may be the consequence of an inappropriate choice of staple size in relation to gastric wall thickness. Due to the variable nature of gastric wall thickness, the choice of proper staple height is not obvious. In the few studies in which gastric wall thickness was measured, it was observed to decrease gradually from the antrum to the fundus...
March 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29642585/mitochondrial-biogenesis-in-diverse-cauliflower-cultivars-under-mild-and-severe-drought-impaired-coordination-of-selected-transcript-and-proteomic-responses-and-regulation-of-various-multifunctional-proteins
#17
Michał Rurek, Magdalena Czołpińska, Tomasz Andrzej Pawłowski, Aleksandra Maria Staszak, Witold Nowak, Włodzimierz Krzesiński, Tomasz Spiżewski
Mitochondrial responses under drought within Brassica genus are poorly understood. The main goal of this study was to investigate mitochondrial biogenesis of three cauliflower ( Brassica oleracea var. botrytis ) cultivars with varying drought tolerance. Diverse quantitative changes (decreases in abundance mostly) in the mitochondrial proteome were assessed by two-dimensional gel electrophoresis (2D PAGE) coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Respiratory (e.g., complex II, IV (CII, CIV) and ATP synthase subunits), transporter (including diverse porin isoforms) and matrix multifunctional proteins (e...
April 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29642584/antileishmanial-activity-of-2-methoxy-4h-spiro-naphthalene-1-2-oxiran-4-one-epoxymethoxy-lawsone-a-promising-new-drug-candidate-for-leishmaniasis-treatment
#18
Luiz Filipe Gonçalves Oliveira, Franklin Souza-Silva, Luzia Monteiro de Castro Côrtes, Lea Cysne-Finkelstein, Mirian Cláudia de Souza Pereira, Francisco Odêncio de Oliveira Junior, Rosa Teixeira Pinho, Suzana Corte Real, Saulo Cabral Bourguignon, Vitor Francisco Ferreira, Carlos Roberto Alves
Epoxymethoxylawsone is a naphthoquinone derivative promising as drug candidate for the treatment of leishmaniases. In the present work the effectiveness of epoxymethoxylawsone, and meglumine antimoniate on Leishmania ( Leishmania ) amazonensis parasites and on mice paw lesions of infected BALB/c mice was assessed. In an intracellular amastigotes assay, the half-maximal inhibitory concentration (IC50 ) value for epoxymethoxylawsone was slightly higher (1.7-fold) than that found for meglumine antimoniate. The efficacy of both drugs became more evident after 48 h of exposure when either the oxirane compound and reference drug reached 18-fold and 7...
April 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29642417/molecular-consortia-various-structural-and-synthetic-concepts-for-more-effective-therapeutics-synthesis
#19
REVIEW
Anna Pawełczyk, Katarzyna Sowa-Kasprzak, Dorota Olender, Lucjusz Zaprutko
The design and discovery of novel drug candidates are the initial and most probably the crucial steps in the drug development process. One of the tasks of medicinal chemistry is to produce new molecules that have a desired biological effect. However, even today the search for new pharmaceuticals is a very complicated process that is hard to rationalize. Literature provides many scientific reports on future prospects of design of potentially useful drugs. Many trends have been proposed for the design of new drugs containing different structures (dimers, heterodimers, heteromers, adducts, associates, complexes, biooligomers, dendrimers, dual-, bivalent-, multifunction drugs and codrugs, identical or non-identical twin drugs, mixed or combo drugs, supramolecular particles and various nanoindividuals...
April 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29629295/-in-vivo-anti-arthritic-and-anti-nociceptive-effects-of-ethanol-extract-of-moringa-oleifera-leaves-on-complete-freund-s-adjuvant-cfa-induced-arthritis-in-rats
#20
Harith Jameel Mahdi, Nurzalina Abdul Karim Khan, Mohd Zaini Bin Asmawi, Roziahanim Mahmud, Vikneswaran A/L Murugaiyah
Background: The medicinal uses of plants are in many cases based exclusively on traditional knowledge without enough scientific evidences. Different parts of Moringa oleifera were traditionally used for the treatment of wide variety of ailments including arthritis and joints pain. The present study had been designed to evaluate the anti-arthritic and anti-nociceptive activities of ethanol extract of Moringa leaves, this being the most abundant plant part suitable for commercial mass production of botanical medicinal products...
March 2018: Integrative Medicine Research
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