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https://www.readbyqxmd.com/read/28346382/the-balloon-based-manometry-evaluation-of-swallowing-in-patients-with-amyotrophic-lateral-sclerosis
#1
Jerzy Tomik, Barbara Tomik, Sebastian Gajec, Piotr Ceranowicz, Małgorzata Pihut, Rafał Olszanecki, Paweł Stręk, Jacek Składzień
The aim of the study was to analyse the disturbances of the oro-pharyngeal swallowing phase of dysphagia in amyotrophic lateral sclerosis (ALS) patients with the use of specific manometric measurements and to evaluate their plausible association with the duration of the disease. Seventeen patients with ALS were evaluated with manometric examinations of the oral and pharyngeal part of the gastrointestinal tract. Tests were carried out by using the oesophageal balloon-based method with four balloon transducers located 5 cm away from each other...
March 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28345350/boron-enhanced-growth-of-micron-length-carbon-based-nanowalls-a-route-towards-high-rates-electrochemical-biosensing
#2
Katarzyna Siuzdak, Mateusz Ficek, Michal Sobaszek, Jacek Ryl, Marcin Gnyba, Paweł Niedziałkowski, Natalia Malinowska, Jakub Karczewski, Robert Bogdanowicz
In this study we have demonstrated the fabrication of novel material called boron-doped carbon nanowalls (B:CNW) which is characterized by remarkable electrochemical properties like high standard rate constant k°, low peak to peak separation value (ΔE) for oxidation and reduction processes of [Fe(CN)6]3-/4- redox system and low surface resistivity. The B:CNW samples were deposited by the microwave plasma assisted chemical vapor deposition (CVD) using a gas mixture of H2:CH4:B2H6 and N2. Growth results in sharp edge, flat and long carbon nanowalls rich in sp2 as well as sp3 hybridized phases...
March 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28345287/contribution-of-platelet-p2y12-receptors-to-chronic-complete-freund-s-adjuvant-induced-inflammatory-pain
#3
K Bekő, B Koványi, F Gölöncsér, G Horváth, Á Dénes, Zs Környei, B Botz, Zs Helyes, C E Müller, B Sperlágh
BACKGROUND: P2Y12 receptor antagonists are widely used in clinical practice to inhibit platelet aggregation. P2Y12 receptors are also known to regulate different forms of pain as well as local and systemic inflammation. However it is not known if platelet P2Y12 receptors contribute to these effects. OBJECTIVES: In this study, we explored the contribution of platelet P2Y12 receptors to chronic inflammatory pain in mice. METHODS: Complete Freund's adjuvant (CFA)-induced chronic inflammatory pain was induced in wild-type and P2ry12 gene-deficient mice (P2ry12-/-), and the potent, direct-acting and reversible P2Y12 receptor antagonists, PSB-0739, and cangrelor were used...
March 27, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28344624/retrograde-recanalization-of-chronic-total-occlusion-a-novel-maneuver-of-the-old-technique
#4
Mariusz Dębski, Artur Dębski, Paweł Tyczyński, Adam Witkowski, Marcin Demkow
No abstract text is available yet for this article.
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/28344621/transseptal-balloon-atrial-septostomy-for-decompression-of-the-left-atrium-during-extracorporeal-membrane-oxygenation-support-as-a-bridge-to-transplantation-in-dilated-cardiomyopathy
#5
Paweł Litwiński, Marcin Demkow, Małgorzata Sobieszczańska, Jarosław Szymański, Józef Stolarek, Mariusz Kuśmierczyk
No abstract text is available yet for this article.
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/28344618/patient-and-lesion-tailored-algorithm-of-endovascular-treatment-for-arterial-occlusive-disease-of-extracranial-arteries-supplying-the-brain-safety-of-the-treatment-at-30-day-follow-up
#6
Paweł Latacz, Marian Simka, Paweł Brzegowy, Piotr Janas, Marek Kazibudzki, Piotr Pieniążek, Andrzej Ochała, Tadeusz Popiela, Tomasz Mrowiecki
INTRODUCTION: Although surgical endarterectomy remains the treatment of choice for carotid artery stenosis, stenting plays an important role as an alternative treatment modality, especially in high-risk patients. The actual safety profile associated with stenting procedures is probably better than that reported by randomized controlled trials. AIM: To assess the safety of stent implantations in extracranial arteries supplying the brain, and also to identify risk factors associated with this procedure...
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/28344614/do-we-need-invasive-confirmation-of-cardiac-magnetic-resonance-results
#7
Paweł Siastała, Jacek Kądziela, Łukasz A Małek, Mateusz Śpiewak, Katarzyna Lech, Adam Witkowski
INTRODUCTION: Coronary artery revascularization is indicated in patients with documented significant obstruction of coronary blood flow associated with a large area of myocardial ischemia and/or untreatable symptoms. There are a few invasive or noninvasive methods that can provide information about the functional results of coronary artery narrowing. The application of more than one method of ischemia detection in one patient to reevaluate the indications for revascularization is used in case of atypical or no symptoms and/or borderline stenosis...
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/28343956/effect-of-cd-2-and-cd-2-auxin-mixtures-on-lipid-monolayers-model-membrane-studies-on-the-role-of-auxins-in-phytoremediation-of-metal-ions-from-contaminated-environment
#8
Katarzyna Hąc-Wydro, Marzena Mach, Karolina Węder, Katarzyna Pająk, Paweł Wydro
In this work Langmuir monolayer experiments were performed to analyze the effect of Cd(2+) ions and their mixtures with synthetic auxin (1-naphthaleneacetic acid - NAA) on lipid films. These investigations were motivated by the fact that auxins act effectively as the agents improving the removal of metal ions from contaminated water and soil by plants (phytoextraction), and although their mechanism of action in this area is still unclear, it was suggested that it can be membrane-related. The experiments were done for one component (1,2-dipalmitoyl-sn-glycero-3-phosphocholine - DPPC; 1,2-dioleoyl-sn-glycero-3-phosphocholine - DOPC; 1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) - DPPG) monolayers and mixed (DPPG/DOPC and DPPG/DPPC) films treated as model of plant leaves membranes...
March 23, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28342857/antinociceptive-and-anti-inflammatory-effects-of-the-methanolic-stem-bark-extract-of-antrocaryon-klaineanum-pierre-anacardiaceae-in-mice-and-rats
#9
Annie Laure Magne Fongang, Edwige Laure Nguemfo, Yolande Djouatsa Nangue, Calvin Bogning Zangueu, Yannick Fouokeng, Anatole Guy Blaise Azebaze, Eulogio José Llorent-Martínez, Maria Luisa Fernández-de Córdova, Alain Bertrand Dongmo, Wolfgang Vierling
ETHNOPHARMACOLOGICAL RELEVANCE: Antrocaryon klaineanum is used by traditional healers to treat many disorders including pain and inflammatory diseases. This study aimed to evaluate the analgesic and antiinflammatory activities of methanol extract of A. klaineanum in mice and rats. MATERIALS AND METHODS: Reverse phase high-performance liquid chromatography (RP-HPLC) was performed to establish the chromatographic fingerprint and to identify various chemical components of the plant extract...
March 22, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28341988/unexpected-differences-between-planar-and-column-liquid-chromatographic-retention-of-1-acenaphthenol-enantiomers-controlled-by-supramolecular-interactions-involving-%C3%AE-cyclodextrin-at-subambient-temperatures
#10
Hatsuichi Ohta, Elżbieta Włodarczyk, Krzysztof Piaskowski, Aleksandra Kaleniecka, Lucyna Lewandowska, Michał J Baran, Mariusz Wojnicz, Kiyokatsu Jinno, Yoshihiro Saito, Paweł K Zarzycki
We report the results of experimental work focusing on host-guest supramolecular complex creation between macrocyclic compound (β-cyclodextrin) and 1-acenaphthenol enantiomers (racemic mixture) in liquid phase composed of 35% acetonitrile in water (v/v) at different temperatures ranging from 0 to 90 °C. Experimental setup involved several analytical protocols based on classical non-forced flow planar chromatography (RP-18 TLC plates), micro-TLC (RP-18 W HPTLC plates), column chromatography (HPLC with C-18 and C-30 stationary phases), as well as UV-Vis spectrophotometry and optical microscopy...
March 24, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28341986/enhancing-effectiveness-of-capillary-electrophoresis-as-an-analytical-tool-in-the-supramolecular-acidity-modification
#11
Paweł Mateusz Nowak, Michał Woźniakiewicz, Magdalena Janus, Paweł Kościelniak
A strategic modification of acidity (pK a values) by the non-covalent host-guest interactions is one of the most promising concepts in current supramolecular chemistry. This work is aimed at enhancing the effectiveness of capillary electrophoresis (CE) in determination of pK a shifts caused by such interactions and their thermal dependencies crucial in a deep thermodynamic description. We show how to (i) minimize the systematic errors related to Joule heating, (ii) minimize the influence of a voltage ramp time, (iii) speed up pK a shift identification and estimation, (iv) interpret thermal effects related to two overlapped dynamic equilibria, and (v) determine pK a shifts by an alternative spectrophotometric method (CE-DAD)...
March 24, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28341722/sciatic-and-femoral-nerve-blockade-using-bupivacaine-alone-or-in-combination-with-dexmedetomidine-or-buprenorphine-in-cats
#12
M C Evangelista, G M Doodnaught, D T Fantoni, P V M Steagall
The aim of this study was to determine the onset and offset of antinociception after sciatic (ScN) and femoral (FN) nerve blocks. Six healthy adult cats (4.8±1.3years; 4.3±0.4 kg) were included in a randomised, crossover, blinded and controlled study. Following sedation with dexmedetomidine (25 µg/kg, intramuscular), each ScN and FN injection was performed using 0.1 ml/kg of saline (CONTROL), bupivacaine (0.46 per cent, 0.46 mg/kg; BUPI), bupivacaine and dexmedetomidine (1 µg/kg; BUPI-DEX) or bupivacaine and buprenorphine (2...
March 24, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28341461/sequential-therapy-of-anti-nogo-a-antibody-treatment-and-treadmill-training-leads-to-cumulative-improvements-after-spinal-cord-injury-in-rats
#13
Kinon Chen, Barnaby C Marsh, Matthew Cowan, Yazi D Al'Joboori, Sylvain Gigout, Calvin C Smith, Neil Messenger, Nikita Gamper, Martin E Schwab, Ronaldo M Ichiyama
Intense training is the most clinically successful treatment modality following incomplete spinal cord injuries (SCIs). With the advent of plasticity enhancing treatments, understanding how treatments might interact when delivered in combination becomes critical. Here, we investigated a rational approach to sequentially combine treadmill locomotor training with antibody mediated suppression of the fiber growth inhibitory protein Nogo-A. Following a large but incomplete thoracic lesion, rats were immediately treated with either anti-Nogo-A or control antibody (2weeks) and then either left untrained or step-trained starting 3weeks after injury for 8weeks...
March 21, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28341433/minimizing-the-impact-of-joule-heating-as-a-prerequisite-for-the-reliable-analysis-of-metal-protein-complexes-by-capillary-electrophoresis
#14
Paweł Mateusz Nowak, Klaudyna Śpiewak, Michał Woźniakiewicz, Paweł Kościelniak
Herein we report on a drastic release of metal ions from the Fe-bound transferrin, and Fe- or Mn-bound lactoferrin, observed upon the increase in the separation voltage during CE-based analysis. To verify whether this process is caused directly by electric field, we developed an Isothermal Voltage Increase approach (IVI), which is the extension of methods reported by Krylov et al. IVI ensures isothermal conditions while increasing separation voltage by a hydrodynamic pushing of the injected sample to the actively cooled capillary section, combined with a rationale choice of cooling temperature, dependent on the value of current...
March 18, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28340784/separation-of-20-coumarin-derivatives-using-the-capillary-electrophoresis-method-optimized-by-a-series-of-doehlert-experimental-designs
#15
Michał Woźniakiewicz, Marta Gładysz, Paweł M Nowak, Justyna Kędzior, Paweł Kościelniak
The aim of this study was to develop the first CE-based method enabling separation of 20 structurally similar coumarin derivatives. To facilitate method optimization a series of three consequent Doehlert experimental designs with the response surface methodology was employed, using number of peaks and the adjusted time of analysis as the selected responses. Initially, three variables were examined: buffer pH, ionic strength and temperature (No. 1 Doehlert design). The optimal conditions provided only partial separation, on that account, several buffer additives were examined at the next step: organic cosolvents and cyclodextrin (No...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28340740/quantification-of-polybrominated-diphenyl-ethers-pbdes-in-food-a-review
#16
REVIEW
Wojciech Jerzy Pietroń, Paweł Małagocki
The polybrominated diphenyl ethers (PBDEs), a class of brominated flame retardants (BFRs), are food contaminants of animal origin. Interest in food matrices analysis is growing due to the toxicity of PBDEs and European Commission (EC) recommendation (118/2014/EU). Here we review papers concerning methods of PBDEs analysis while focusing on extraction, clean up, chromatographic separation and detection techniques. The emphasis is put on EC recommendation, the congeners and the efficiency of different detection systems...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28339439/dezocine-antagonizes-morphine-analgesia-upon-simultaneous-administration-in-rodent-models-of-acute-nociception
#17
Na-Na Li, Ya-Qin Huang, Ling-Er Huang, Shao-Hui Guo, Maxwell R Shen, Chen-Ling Guo, Sheng-Mei Zhu, Yong-Xing Yao
BACKGROUND: Dezocine is a powerful analgesic that can be less addictive than morphine, yet how the two drugs interact in vivo is poorly understood. Here we administered dezocine alone or in combination with morphine to different acute nociception paradigms to explore the interactions of the 2 drugs upon co-administration. OBJECTIVE: To evaluate how dezocine interacts with morphine in different acute nociception paradigms. STUDY DESIGN: Laboratory animal study...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28338602/design-and-synthesis-of-novel-pyrazole-substituted-different-nitrogenous-heterocyclic-ring-systems-as-potential-anti-inflammatory-agents
#18
Eman S Nossier, Hoda H Fahmy, Nagy M Khalifa, Wafaa I El-Eraky, Marawan A Baset
With the aim of developing novel anti-inflammatory scaffolds, a new series of pyrazole-substituted various nitrogenous heterocyclic ring systems at C-4 position were synthesized through different chemical reactions and validated by means of spectral and elemental data. The new obtained compounds were investigated for their anti-inflammatory activity using the carrageenan-induced paw edema standard technique and revealed that, compound 6b showed increased potency with % inhibition of edema 85.23 ± 1.92 and 85...
March 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28337957/transplantation-of-cultured-olfactory-bulb-cells-prevents-abnormal-sensory-responses-during-recovery-from-dorsal-root-avulsion-in-the-rat
#19
Andrew Collins, Daqing Li, Stephen B McMahon, Geoffrey Raisman, Ying Li
The central branches of the C7 and C8 dorsal roots were avulsed close to their entry point into the spinal cord in adult rats. The forepaw responses to heat and cold stimuli were tested at 1, 2 and 3 weeks after injury. Over this period the paws were sensitive to both stimuli at 1-2 weeks and returned towards normal at 3 weeks. Immunohistology showed no evidence of axonal regeneration into the spinal cord in a control group of rats with avulsion only, implying that adjacent dorsal roots and their corresponding dermatomes were involved in the recovery...
March 23, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28337462/time-and-dose-dependent-effects-of-17-beta-estradiol-on-short-term-real-time-proliferation-and-gene-expression-in-porcine-granulosa-cells
#20
Sylwia Ciesiółka, Joanna Budna, Karol Jopek, Artur Bryja, Wiesława Kranc, Sylwia Borys, Michal Jeseta, Adrian Chachuła, Agnieszka Ziółkowska, Paweł Antosik, Dorota Bukowska, Klaus P Brüssow, Małgorzata Bruska, Michał Nowicki, Maciej Zabel, Bartosz Kempisty
The key mechanisms responsible for achievement of full reproductive and developmental capability in mammals are the differentiation and transformation of granulosa cells (GCs) during folliculogenesis, oogenesis, and oocyte maturation. Although the role of 17 beta-estradiol (E2) in ovarian activity is widely known, its effect on proliferative capacity, gap junction connection (GJC) formation, and GCs-luteal cells transformation requires further research. Therefore, the goal of this study was to assess the real-time proliferative activity of porcine GCs in vitro in relation to connexin (Cx), luteinizing hormone receptor (LHR), follicle stimulating hormone receptor (FSHR), and aromatase (CYP19A1) expression during short-term (168 h) primary culture...
2017: BioMed Research International
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