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https://www.readbyqxmd.com/read/29217257/upregulation-of-bdnf-and-interleukin-1%C3%A3-in-rat-spinal-cord-following-noxious-hind-paw-stimulation
#1
Josef Donnerer, Ingrid Liebmann
The aim of the present study was to investigate the protein levels of BDNF and IL-1ß in the lumbar dorsal horn of the rat by Western blot analysis following a noxious thermal hind paw stimulation. Ten min, 1h and 3h after the combined chemical and thermal stimulation an up to 2-fold increase in BDNF and Il-1ß protein expression was observed in the lumbar dorsal spinal cord. A pretreatment with the opioid analgesic morphine or the glial cell activation inhibitor minocycline partly attenuated protein expression...
December 4, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29215830/-study-of-migration-and-distribution-of-bone-marrow-cells-transplanted-animals-with-b16-melanoma
#2
A F Poveshchenko, A O Solovieva, K E Zubareva, D N Strunkin, O B Gricyk, O V Poveshchenko, A V Shurlygina, V I Konenkov
Purpose. Reveal features migration and distribution of syngeneic bone marrow cells (BMC) and subpopulations (MSC) after transplantation into the recipient carrier B16 melanoma bodies. Methods. We used mouse male and female C57BL/6 mice. Induction of Tumor Growth: B16 melanoma cells implanted subcutaneously into right hind paw of female C57BL/6 mice at a dose of 2.5 x 105 cells / mouse. migration study in vivo distribution and BMC and MSC was performed using genetic markers - Y-chromosome specific sequence line male C57Bl/6 syngeneic intravenous transplantation in females using the polymerase chain reaction (PCR) in real time on Authorized Termal Cycler - Light Cycler 480 II / 96 (Roche)...
April 2017: Patologicheskaia Fiziologiia i èksperimental'naia Terapiia
https://www.readbyqxmd.com/read/29214971/corrigendum-evidence-for-immune-activation-in-patients-with-residual-hepatitis-c-virus-rna-long-after-successful-treatment-with-ifn-and-ribavirin
#3
Marek Radkowski, Jolanta Opoka-Kegler, Kamila Caraballo Cortes, Iwona Bukowska-Ośko, Karol Perlejewski, Agnieszka Pawełczyk, Tomasz Laskus
No abstract text is available yet for this article.
December 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29214481/environmental-levels-of-triclosan-and-male-fertility
#4
Joanna Jurewicz, Michał Radwan, Bartosz Wielgomas, Paweł Kałużny, Anna Klimowska, Paweł Radwan, Wojciech Hanke
Triclosan is a synthetic chemical with broad antimicrobial activity that has been used extensively in consumer products, including personal care products, textiles, and plastic kitchenware, although the exposure which is widespread evidence from human studies is scarce. Our study aims to investigate the relationship between triclosan exposure and male fertility. Triclosan (TCS) urinary concentrations were measured using gas chromatography coupled with tandem mass spectrometry in 315 men recruited from a male reproductive health clinic with normal sperm concentration (≥ 15 mln/ml) (WHO 2010) under 45 years of age...
December 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29212832/adenosine-a-2a-receptor-agonist-2-p-2-carboxyethyl-phenethylamino-5-n-ethylcarboxamidoadenosine-hydrochloride-hydrate-cgs21680-inhibits-inflammation-and-increases-fibroblast-growth-factor-2-fgf-2-tissue-expression-in-carrageenan-induced-rat-paw-edema
#5
Armando Ialenti, Elisabetta Caiazzo, Silvana Morello, Rosa Carnuccio, Carla Cicala
Adenosine is the final product of ATP metabolism, mainly derived from the action of 5'-nucleotidase cleavage of AMP. Cellular production of adenosine is greatly enhanced in inflamed tissues, ischemic tissues and under hypoxia, where ATP is released from damaged cells. Much evidence has been accumulated on adenosine antinflammatory effects mediated through A 2A receptor activation; A2A adenosine receptor has also been shown to play a role in matrix deposition and wound healing in a damaged tissue, contributing to dermal tissue protection and repair...
December 6, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29211359/continent-catheterizable-conduits-in-pediatric-urology-one-center-experience
#6
Paweł Kroll, Ewa Gajewska, Jacek Zachwieja, Danuta Ostalska-Nowicka, Maciej Micker, Andrzej Jankowski
BACKGROUND: Clean intermittent catheterization (CIC) is a standard treatment for patients who are unable to empty the bladder. In the absence of the urethra or if catheterization through the urethra is problematic, a continent vesicostomy is used as a catheterizable conduit. The Malone procedure is an established treatment option for children with neurogenic constipation and fecal incontinence. OBJECTIVES: The aim of the study was to report the authors' experience with continent catheterizable conduits (CCCs) in children, to review the results and to determine the efficacy of the technique, with an emphasis on continence and the need for revision...
October 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29211353/evaluation-of-nmp22-in-bladder-cancer-patients-sensitive-to-environmental-toxins
#7
Beata Szymańska, Krzysztof J Pawlik, Ewa Sawicka, Janusz Dembowski, Paweł Kowal, Romuald Zdrojowy, Anna Długosz
BACKGROUND: Bladder cancer (BC) is recognized as environmentally related. The interaction of environmental exposure to chemicals and genetic susceptibility seem to play important roles in BC development. In order to improve diagnosis and the recognition of BC risk, a group of markers which combine genetic susceptibility with detoxification and nuclear matrix protein (NMP22) is proposed. OBJECTIVES: The aim of the study was to examine the utility of nuclear matrix protein (NMP22) as a diagnostic marker in BC in genetic susceptibility (NAT2 slow acetylators) combined with detoxification abilities (glutathione S-transferase GST and isoenzyme GST-π)...
October 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29210306/synergistic-antinociceptive-activity-of-combined-aqueous-extracts-of-artemisia-campestris-and-artemisia-herba-alba-in-several-acute-pain-models
#8
Imededdine Kadi, Mohamed Ouinten, Nadhir Gourine, Mohamed Yousfi
In this study, total phenolic and flavonoid contents, acute toxicity and the antinociceptive activity of Artemisia campestris and Artemisia herba-alba, individually and in combination, were investigated using multiple forms of pain in animals. Our results have been shown that plants are relatively safe without clinical signs of toxicity in animals. Thus, extracts were presented high levels in phenolic and flavonoid contents. Artemisia decoctions with 100, 200, 400 mg/kg b-w studied dose, clearly attenuate chemical and thermal noxious stimuli in writhing, formalin and hot-plate tests, and significantly reduced paw oedema in formalin test...
December 6, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29210299/new-cyclopentaquinoline-hybrids-with-multifunctional-capacities-for-the-treatment-of-alzheimer-s-disease
#9
Kamila Czarnecka, Małgorzata Girek, Karolina Maciejewska, Robert Skibiński, Jakub Jończyk, Marek Bajda, Jacek Kabziński, Przemysław Sołowiej, Ireneusz Majsterek, Paweł Szymański
Alzheimer's disease (AD) is the most common progressive form of brain neurodegeneration and the most prevailing cause of dementia. Unfortunately, the aetiology of AD is not completely studied but different factors are associated with the development of AD such as among others low level of acetylcholine, aggregation of β-amyloid (Aβ), hyperphosphorylated tau protein, oxidative stress, and inflammation. The study encompass organic syntheses of 2,3-dihydro-1H-cyclopenta[b]quinoline with 5,6-dichloronicotinic acid and suitable linkers derivatives as multifunctional agents for AD treatment...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29210121/proanthocyanidin-rich-pinus-radiata-bark-extract-inhibits-mast-cell-mediated-anaphylaxis-like-reactions
#10
Yun Ho Choi, Chang Ho Song, Sung Phil Mun
Mast cells play a critical role in the effector phase of immediate hypersensitivity and allergic reactions. Pinus radiata bark extract exerts multiple biological effects and exhibits immunomodulatory and antioxidant properties. However, its role in mast cell-mediated anaphylactic reactions has not been thoroughly investigated. In this study, we examined the effects of proanthocyanidin-rich water extract (PAWE) isolated from P. radiata bark on compound 48/80-induced or antidinitrophenyl (DNP) immunoglobulin E (IgE)-mediated anaphylaxis-like reactions in vivo...
December 6, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29209243/love-influences-reproductive-success-in-humans
#11
Piotr Sorokowski, Agnieszka Sorokowska, Marina Butovskaya, Maciej Karwowski, Agata Groyecka, Bogdan Wojciszke, Bogusław Pawłowski
As love seems to be universal, researchers have attempted to find its biological basis. However, no studies till date have shown its direct association with reproductive success, which is broadly known to be a good measure of fitness. Here, we show links between love, as defined by the Sternberg Triangular Theory of Love, and reproductive success among the Hadza-traditional hunter-gatherer population. We found that commitment and reproductive success were positively and consistently related in both sexes, with number of children showing negative and positive associations with intimacy and passion, respectively, only among women...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29209170/noradrenaline-modulates-the-membrane-potential-and-holding-current-of-medial-prefrontal-cortex-pyramidal-neurons-via-%C3%AE-1-adrenergic-receptors-and-hcn-channels
#12
Katarzyna Grzelka, Przemysław Kurowski, Maciej Gawlak, Paweł Szulczyk
The medial prefrontal cortex (mPFC) receives dense noradrenergic projections from the locus coeruleus. Adrenergic innervation of mPFC pyramidal neurons plays an essential role in both physiology (control of memory formation, attention, working memory, and cognitive behavior) and pathophysiology (attention deficit hyperactivity disorder, posttraumatic stress disorder, cognitive deterioration after traumatic brain injury, behavioral changes related to addiction, Alzheimer's disease and depression). The aim of this study was to elucidate the mechanism responsible for adrenergic receptor-mediated control of the resting membrane potential in layer V mPFC pyramidal neurons...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29209138/effects-of-glutathione-on-mechanical-allodynia-and-central-sensitization-in-chronic-postischemic-pain-rats
#13
Jinseok Yeo, Hoon Jung, Hyerim Lee
Background: The chronic postischemia pain (CPIP) model is an animal model using ischemia/reperfusion injury that mimics the symptoms of complex regional pain syndrome type I. Glutathione (GSH) prevents ischemia/reperfusion injury by scavenging free radicals. We conducted this study to investigate the protective effect of GSH in CPIP rats via changes of mechanical allodynia and phospholyration of the N-methyl-D-aspartate receptor subunit GluN1. Methods: We divided 45 rats into 5 groups: sham, CPIP, CPIP + GSH 100 mg/kg, CPIP + GSH 200 mg/kg, and CPIP + GSH 500 mg/kg...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29206644/antinociceptive-and-antioxidant-activities-of-hunteria-umbellata-stem-bark-possible-role-of-the-serotonergic-opioidergic-and-dopaminergic-pathways
#14
Osaze Edosuyi, Ighodaro Igbe, Loretta Oghenekome Iniaghe
Background Hunteria umbellata (HU) (K. Schum) is used in ethnomedicine for the management of pain, diabetes mellitus and dysmenorrhoea. This study evaluated the analgesic and antioxidant activities of aqueous extract of HU stem bark and the possible mechanism(s) of action. Methods The antinociceptive effect of HU was evaluated using acetic acid mouse writhing, tail flick, hot plate and formalin-induced paw licking models. To establish the possible mechanism(s) of action of HU, separate group of animals were pretreated with naloxone (1 mg/kg, i...
December 5, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29206131/influence-of-maternal-care-on-behavioural-development-of-domestic-dogs-canis-familiaris-living-in-a-home-environment
#15
Giovanna Guardini, Jon Bowen, Chiara Mariti, Jaume Fatjó, Claudio Sighieri, Angelo Gazzano
Maternal care has been shown to affect the development of the brain, behaviour, social skills and emotional systems of the young of many mammalian species including dogs. The aim of the present study was to determine the effects of maternal care on the behavioural responses of family dog puppies towards environmental and social stimuli. In order to do this, maternal care (licking puppy's ano-genital area, licking the puppy, nursing and mother-puppy contact) during the first three weeks after birth was assessed in 12 litters of domestic dog puppies reared in home environments (total = 72 puppies)...
December 5, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29205212/experimental-identification-of-a-mathematical-model-of-human-operator-working-under-mental-stress
#16
Antoni Kopyt, Krystyna Zużewicz, Paweł Bartuzi
In engineering the human is considered as one of the system elements. In most studies, his/her model remains unchanged due to the external factors. The present study shows that a relation between the mental stress and human dynamics cannot be neglected. The dynamic characteristics of the operator model change due to external stimuli, i.e., mental stress. The aim of this study was to present identification of a mathematical human model and measurement methodology of the mental stress level. To determine the level of human response to external stimuli, the electrocardiography (ECG) and electromyography (EMG) methods were applied...
2017: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29205209/foot-mechanics-in-young-women-are-altered-after-walking-in-high-heeled-shoes
#17
Sławomir Winiarski, Alicja Rutkowska-Kucharska, Paweł Zostawa, Natalia Uścinowicz-Zostawa, Sebastian Klich
PURPOSE: Nowadays, fashion has caused that many young women are wearing high-heeled shoes. Therefore, the aim of this study was to examine the effects of long-term walking in high-heeled shoes on the foot mechanics during barefoot gait. METHODS: Forty-three young women (22 ± 2.1 years) divided into two groups participated in this retrospective cohort study. The first group was composed of women who frequently wear high-heeled footwear. The second, infrequent wearers group, consisted of women who preferred flat-heeled shoes...
2017: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29205120/synthesis-and-in-vitro-antioxidant-activity-study-of-some-novel-substituted-piperazinyl-flavone-compounds
#18
Elmas Sari, Paweł Berczynski, Aleksandra Kładna, Irena Kruk, Oya B Dundar, Monika Szymanska, Hassan Y Aboul-Enein
BACKGROUND: A new series of 13 piperazinyl flavone derivatives has been synthesized and examined for their in vitro antiradical and antioxidant activities as response to the pharmacy industry's increasing demand for new non-toxic anti-inflammatory and anticancer drugs. METHODS: Their antioxidant activity was evaluated by the reactive oxygen species (ROS) scavenging assays, 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH ) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical cation (ABTS+ ) scavenging assays, and the ferric reducing antioxidant potency (TAC) method, and compared to known positive controls, herbal infusions, and penicillins...
December 3, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/29203733/-assessment-of-knowledge-about-hypothermia-among-the-medical-personnel-of-polish-medical-air-rescue
#19
Tomasz Derkowski, Sylweriusz Kosiński, Paweł Podsiadło, Tomasz Sanak, Kinga Sałapa, Arkadiusz Wejnarski, Robert Gałązkowski, Tomasz Darocha
Polish Medical Air Rescue is tasked to deal with the most serious incidents associated with life threatening situations, in multiple circumstances. As a consequence, medical personnel have to meet high standards of education and show a continuous theoretical and practical development of the skills which are necessary during medical treatment. Thanks to the introduction of ECMO treatment for accidental hypothermia patients, new clinical and operational possibilities have arisen, so more patients can be saved with a very good neurological outcome...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29203652/divergence-of-regulatory-networks-governed-by-the-orthologous-transcription-factors-flc-and-pep1-in-brassicaceae-species
#20
Julieta L Mateos, Vicky Tilmes, Pedro Madrigal, Edouard Severing, René Richter, Colin W M Rijkenberg, Paweł Krajewski, George Coupland
Genome-wide landscapes of transcription factor (TF) binding sites (BSs) diverge during evolution, conferring species-specific transcriptional patterns. The rate of divergence varies in different metazoan lineages but has not been widely studied in plants. We identified the BSs and assessed the effects on transcription of FLOWERING LOCUS C (FLC) and PERPETUAL FLOWERING 1 (PEP1), two orthologous MADS-box TFs that repress flowering and confer vernalization requirement in the Brassicaceae species Arabidopsis thaliana and Arabis alpina, respectively...
December 4, 2017: Proceedings of the National Academy of Sciences of the United States of America
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