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https://www.readbyqxmd.com/read/28191707/mechanisms-underlying-reflux-symptoms-and-dysphagia-in-patients-with-joint-hypermobility-syndrome-with-and-without-postural-tachycardia-syndrome
#1
A Fikree, Q Aziz, D Sifrim
BACKGROUND: The joint hypermobility syndrome (JHS) is a common non-inflammatory connective tissue disorder which frequently co-exists with postural tachycardia syndrome (PoTS), a form of orthostatic intolerance. Gastrointestinal symptoms and dysmotility have been reported in PoTS. Dysphagia and reflux are common symptoms in JHS, yet no studies have examined the physiological mechanism for these, subdivided by PoTS status. METHODS: Thirty patients (28 female, ages: 18-62) with JHS and symptoms of reflux (n=28) ± dysphagia (n=25), underwent high-resolution manometry and 24 hour pH-impedance monitoring after questionnaire-based symptom assessment...
February 12, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28145965/laparoscopic-anterior-partial-fundoplication-is-comparable-with-nissen-fundoplication-for-gastroesophageal-reflux-disease
#2
Pawanindra Lal, Swati H Shah, Nitin Leekha, Amarender Singh Puri
BACKGROUND: Laparoscopic Nissen fundoplication (LNF) has been the gold standard for gastroesophageal reflux disease (GERD), but the side effects of dysphagia and bloating have lead to interest in partial fundoplication as an alternative. AIM: To compare the symptomatic and objective parameters after LNF and laparoscopic anterior partial fundoplication (LAPF) in patients with GERD. PATIENTS AND METHODS: The study was conducted in the Division of Minimal Access Surgery, Maulana Azad Medical College from June 2008 to October 2016...
February 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28133854/waist-to-hip-ratio-is-a-better-predictor-of-esophageal-acid-exposure-than-body-mass-index
#3
C Ringhofer, J Lenglinger, M Riegler, I Kristo, A Kainz, S Schoppmann
BACKGROUND: Obesity and gastroesophageal reflux disease (GERD) are major health problems showing an inconstant relationship in the literature. Therefore, anthropometric parameters which are predictive and can simply be assessed at first patient presentation may lead to a better patient selection for ambulatory reflux monitoring. We aimed to examine the association of body mass index (BMI) and waist to hip ratio (WHR) with gastroesophageal reflux activity during 24 hour-pH-impedance monitoring...
January 29, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28045635/association-between-laryngeal-pepsin-levels-and-the-presence-of-vocal-fold-polyps
#4
Lu Wang, Jia-Jie Tan, Ting Wu, Rui Zhang, Jia-Nuan Wu, Fang-Fang Zeng, You-Li Liu, Xiao-Yan Han, Yan-Fei Li, Xiang-Ping Li
Objective To determine whether pepsin, the main component of refluxed gastric contents, is significantly associated with vocal fold polyps and to evaluate the diagnostic value of pepsin in vocal fold polyps' tissues. Study Design Cross-sectional study. Setting Nanfang Hospital of Southern Medical University. Subjects and Methods The study included 32 patients with vocal fold polyps and 16 healthy controls between 2011 and 2012. Reflux symptom index and reflux finding score assessments, 24-hour combined multichannel intraluminal impedance and pH monitoring, and biopsy of the vocal fold polyp tissues or posterior laryngeal mucosa (healthy controls) for immunohistochemical pepsin staining were performed...
January 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28011948/molecular-hydrogen-affords-neuroprotection-in-a-translational-piglet-model-of-hypoxic-ischemic-encephalopathy
#5
J Nemeth, V Toth-Szuki, V Varga, V Kovacs, G Remzso, F Domoki
Hypoxic-ischemic encephalopathy (HIE) is the major consequence of perinatal asphyxia (PA) in term neonates. Although the newborn piglet is an accepted large animal PA/HIE model, there is no consensus on PA-induction methodology to produce clinically relevant HIE. We aimed to create and to characterize a novel PA model faithfully reproducing all features of asphyxiation including severe hypercapnia resulting in HIE, and to test whether H2 is neuroprotective in this model. Piglets were anaesthetised, artificially ventilated, and intensively monitored (electroencephalography, core temperature, O2 saturation, arterial blood pressure and blood gases)...
October 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28008387/role-of-ph-monitoring-in-laryngopharyngeal-reflux-patients-with-voice-disorders
#6
Swati Maldhure, Ramanathan Chandrasekharan, Amit-Kumar Dutta, Ashok Chacko, Mary Kurien
INTRODUCTION: Laryngopharyngeal reflux (LPR) is considered an important cause of voice disorder. We aimed to determine the frequency of LPR in patients with voice disorder and the association between Koufman Reflux Symptom Index (RSI), Reflux Finding Score (RFS), gastroesophageal reflux disease (GERD), and proximal acid reflux in these patients. MATERIALS AND METHODS: We performed a prospective study in patients aged more than 18 years presenting at the ear, nose, and throat (ENT) clinic with a change in voice lasting more than 3 weeks...
November 2016: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28004504/association-between-24-hour-combined-multichannel-intraluminal-impedance-ph-monitoring-and-symptoms-or-quality-of-life-in-patients-with-laryngopharyngeal-reflux
#7
S I Kim, O E Kwon, S Y Na, Y C Lee, J M Park, Y G Eun
OBJECTIVE: To evaluate the association between the parameters of 24-hour multichannel intraluminal impedance (MII)-pH monitoring and the symptoms or quality of life (QoL) in laryngopharyngeal reflux (LPR) patients. DESIGN: Prospective cohort study without controls. SETTING: University teaching hospital. METHODS: Forty-five LPR patients were selected from subjects who underwent 24-hour MII-pH monitoring and were diagnosed with LPR from September 2014 to May 2015...
December 22, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28002471/dose-finding-study-of-omeprazole-on-gastric-ph-in-neonates-with-gastro-esophageal-acid-reflux-using-a-bayesian-sequential-approach
#8
Florentia Kaguelidou, Corinne Alberti, Valerie Biran, Olivier Bourdon, Caroline Farnoux, Sarah Zohar, Evelyne Jacqz-Aigrain
OBJECTIVE: Proton pump inhibitors are frequently administered on clinical symptoms in neonates but benefit remains controversial. Clinical trials validating omeprazole dosage in neonates are limited. The objective of this trial was to determine the minimum effective dose (MED) of omeprazole to treat pathological acid reflux in neonates using reflux index as surrogate marker. DESIGN: Double blind dose-finding trial with continual reassessment method of individual dose administration using a Bayesian approach, aiming to select drug dose as close as possible to the predefined target level of efficacy (with a credibility interval of 95%)...
2016: PloS One
https://www.readbyqxmd.com/read/27928793/-subtype-classification-and-clinicopathological-characteristics-of-gastric-neuroendocrine-neoplasms-an-analysis-of-241-cases
#9
Pan Zhang, Yu Zhang, Chi Zhang, Yanfen Shi, Jixi Liu, Qing Liu, Lili Yu, Miao Wang, Guoming Zou, Jie Lou, Jie Chen, Huangying Tan
OBJECTIVE: To study subtype classification of gastric neuroendocrine neoplasm (NEN) and their clinicopathological characteristics in order to provide reference for clinical practice. METHODS: Clinicopathological data of 241 gastric NEN patients (174 cases from China-Japan Friendship Hospital and 67 cases from The First Affiliated Hospital of Sun Yat-Sen University) between January 2011 and June 2016 were retrospectively summarized. According to serum gastrin, 24-hour intragastric pH monitoring and pathological grade, patients with gastric NEN were divided into 4 types: type I( (hypergastrinemia and achlorhydria, related to autoimmune chronic atrophic gastritis), type II( [hypergastrinemia and Zollinger-Ellison syndrome, related to gastrinoma or multiple endocrine neoplasia type I( (MEN-I()], type III( (sporadic disease with normal serum gastrin level), and type IIII( [poorly differentiated gastric neuroendocrine carcinoma (NEC) and mixed adenoneuroendocrine carcinoma (MANEC)]...
November 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27920480/comparison-of-multichannel-intraluminal-impedance-ph-monitoring-and-reflux-scintigraphy-in-pediatric-patients-with-suspected-gastroesophageal-reflux
#10
Nuray Uslu Kızılkan, Murat Fani Bozkurt, Inci Nur Saltık Temizel, Hülya Demir, Aysel Yüce, Biray Caner, Hasan Özen
AIM: To evaluate the agreement of multichannel intraluminal impedance-pH monitoring (MII-pHM) and gastroesophageal reflux scintigraphy (GES) for the diagnosis of gastroesophageal reflux disease. METHODS: Seventy-five consecutive patients with suspected gastroesophageal reflux disease (GERD) underwent 24-h combined MII-pHM recording and one hour radionuclide scintigraphy during the course of the MII-pHM study. Catheters with 6 impedance channels and 1 pH sensor were placed transnasally...
November 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27916213/gastric-ph-and-therapeutic-responses-to-exsomeprazole-in-patients-with-functional-dyspepsia-potential-clinical-implications
#11
Marek Majewski, Irene Sarosiek, Chad J Cooper, Grzegorz Wallner, Richard W McCallum, Stanley A Edlavitch, Jerzy Sarosiek
BACKGROUND: Therapy for functional dyspepsia remains a challenge. This study aimed to evaluate esomeprazole (E) versus placebo (P) regarding (1) the effectiveness in providing relief of abdominal pain or discomfort during 16 weeks of therapy in patients with functional dyspepsia having moderate or severe symptoms; (2) the effects on gastric acid suppression and (3) the relationship between symptom relief and gastric pH. METHODS: Enrolled patients were randomized to E (n = 38) or P (n = 35) in a double-blind, placebo-controlled trial...
December 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27875359/symptom-index-or-symptom-association-probability-a-closer-look-at-symptom-association-in-suspected-gerd-patients
#12
Mustafa Abdul-Hussein, Crystal Zhang, Donald Castell
BACKGROUND: Symptom index (SI) and symptom association probability (SAP) are popular methods used to measure symptom association in patients with gastroesophageal reflux disease (GERD). AIM: To investigate whether these 2 methods yield similar results in analysis of both typical and atypical GERD symptoms. MATERIALS AND METHODS: Combined impedance-pH reflux studies of 1471 patients tested for possible GERD symptoms from January 2010 to May 2015 were reviewed...
November 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27862298/two-years-experience-of-using-the-bravo-wireless-oesophageal-ph-monitoring-system-at-a-single-uk-tertiary-centre
#13
Nagendra M Rao, David I Campbell, Prithviraj Rao
AIM: The Bravo wireless pH monitoring system enables oesophageal pH to be monitored in children intolerant to nasal catheters and records measurements over 48 hours. This study aimed to document the minimum child weight that enabled successful capsule placement and any associated complications. We also compared the diagnostic sensitivity of 48 hours versus 24 hours. METHODS: We included 203 consecutive patients (122 male children) with clinically documented or suspected reflux symptoms...
February 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/27804042/esophageal-mucosal-integrity-improves-after-laparoscopic-antireflux-surgery-in-children-with-gastroesophageal-reflux-disease
#14
Femke A Mauritz, Nicolaas F Rinsma, Ernest L W van Heurn, Cornelius E J Sloots, Peter D Siersema, Roderick H J Houwen, David C van der Zee, Ad A M Masclee, José M Conchillo, Maud Y A Van Herwaarden-Lindeboom
BACKGROUND: Esophageal intraluminal baseline impedance reflects the conductivity of the esophageal mucosa and may be an instrument for in vivo evaluation of mucosal integrity in children with gastroesophageal reflux disease (GERD). Laparoscopic antireflux surgery (LARS) is a well-established treatment option for children with proton pump inhibitory (PPI) therapy resistant GERD. The effect of LARS in children on baseline impedance has not been studied in detail. The aim of this study was to evaluate the effect of LARS on baseline impedance in children with GERD...
November 1, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27803732/bioavailability-safety-and-pharmacodynamics-of-delayed-release-dexlansoprazole-administered-as-two-30-mg-orally-disintegrating-tablets-or-one-60-mg-capsule
#15
Michael Kukulka, Sai Nudurupati, Maria Claudia Perez
BACKGROUND: Dual delayed-release dexlansoprazole is approved for use in adults as a 30 mg orally disintegrating tablet (ODT) or as 30 mg and 60 mg capsules. The pharmacokinetics, pharmacodynamics, and safety profile of two dexlansoprazole 30 mg ODTs were compared with one dexlansoprazole 60 mg capsule in this randomized, phase I, open-label, single-center, multiple-dose, two-period crossover study. METHODS: Participants were randomized in one of two treatment sequences, each comprised two 5-day treatment periods during which two dexlansoprazole 30 mg ODTs or one 60 mg capsule was administered once daily...
November 2016: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/27766735/perfusion-of-the-gastric-conduit-during-esophagectomy
#16
Gustav Linder, Jakob Hedberg, Martin Björck, Magnus Sundbom
In esophageal cancer surgery, perfusion of the gastric conduit is a critical issue. Measurement of gastric intramucosal pH (pHi ) is a method to identify anaerobic metabolism as a sign of impaired perfusion. In this study we aimed to monitor changes in the perfusion of the gastric conduit at key steps during and after esophagectomy. pHi was measured per- and postoperatively using intermittent gastric tonometry in 32 patients undergoing open, 65%, or video-assisted thoracoscopic esophagectomy for esophageal cancer...
October 21, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27727523/the-importance-of-combined-24-hour-multichannel-intraluminal-impedance-ph-monitoring-in-the-evaluation-of-children-with-suspected-laryngopharyngeal-reflux
#17
I Pavić, I Babić, J Čepin Bogović, I Hojsak
OBJECTIVE: The aim of this study was to investigate the diagnostic usefulness of combined multichannel intraluminal impedance-pH (MII-pH) monitoring in children with suspected laryngopharyngeal reflux (LPR). DESIGN, SETTING AND PARTICIPANTS: A prospective study including children in whom, due to LPR suggestive symptoms, MII-pH monitoring was performed at tertiary medical centre from February 2012 to July 2015. INTERVENTIONS: All included children underwent same diagnostic protocol which included examination by single pulmonologist and ENT specialist and underwent 24-hour MII-pH monitoring...
October 11, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27693175/esophageal-abnormalities-in-juvenile-localized-scleroderma-is-it-associated-with-other-extracutaneous-manifestations
#18
Clarissa C M Valões, Glaucia V Novak, Juliana B Brunelli, Katia T Kozu, Ricardo K Toma, Clovis A Silva
OBJECTIVE: To assess esophageal involvement (EI) in juvenile localized scleroderma (JLS) population and the possible association between this gastrointestinal manifestation and demographic data, clinical features, laboratory exams, treatments and outcomes. METHODS: For a period of 31 years, 5,881 patients with rheumatic diseases were followed in our Pediatric Rheumatology Division. EI was defined by the presence of symptoms (solid/liquid dysphagia, heartburn, esophageal regurgitation, nausea/vomiting and epigastralgia) and confirmed by at least one EI exam abnormality: barium contrast radiography, upper gastrointestinal endoscopy and 24-hour esophageal pH-monitoring...
September 17, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27666703/-a-comparison-of-ph-4-and-ph-5-as-thresholds-for-24-hour-ph-monitoring-in-the-diagnosis-of-laryngopharyngeal-reflux
#19
J S Wang, J R Li
Objective: To evaluate the consistency between 24-hour pH monitoring, reflux symptom index(RSI) and reflux finding score(RFS) when using pH<4 or pH<5 as threshold for 24-hour pH monitoring in the diagnosis of laryngopharyngeal reflux. Methods: Patients who presented with suspicious laryngopharyngeal reflux between February 2014 and December 2015 were included in this study. pH<4 and pH<5 reflux episodes, RSI and RFS were collected. The consistency between 24-hour pH monitoring and scale results were analyzed when pH<4 or pH<5 as threshold respectively...
September 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27630010/the-impact-of-the-speed-of-food-intake-on-gastroesophageal-reflux-events-in-obese-female-patients
#20
Serhat Bor, Askin Erdogan, Berna Bayrakci, Esra Yildirim, Rukiye Vardar
Obesity increases the risk of gastroesophageal reflux disease (GERD). The majority of the reflux attacks occur postprandially. The influence of the speed of food intake on gastroesophageal reflux events is unclear in obese patients. To determine the influence of the speed of food intake on intraesophageal reflux events in obese patients with and without GERD. A total of 26 obese female patients were recruited. The patients underwent esophageal manometry to evaluate the upper limit of the lower esophageal sphincter and subsequently placement of a Multichannel intraluminal impedance-pH (MII-pH) catheter...
September 15, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
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