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https://www.readbyqxmd.com/read/29051543/cryoem-structure-of-saccharomyces-cerevisiae-u1-snrnp-offers-insight-into-alternative-splicing
#1
Xueni Li, Shiheng Liu, Jiansen Jiang, Lingdi Zhang, Sara Espinosa, Ryan C Hill, Kirk C Hansen, Z Hong Zhou, Rui Zhao
U1 snRNP plays a critical role in 5'-splice site recognition and is a frequent target of alternative splicing factors. These factors transiently associate with human U1 snRNP and are not amenable for structural studies, while their Saccharomyces cerevisiae (yeast) homologs are stable components of U1 snRNP. Here, we report the cryoEM structure of yeast U1 snRNP at 3.6 Å resolution with atomic models for ten core proteins, nearly all essential domains of its RNA, and five stably associated auxiliary proteins...
October 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29028624/foot-pressure-pattern-hindfoot-deformities-and-their-associations-with-foot-pain-in-individuals-with-advanced-medial-knee-osteoarthritis
#2
Isao Saito, Kyoji Okada, Masahiko Wakasa, Hidekazu Abe, Akira Saito
This survey clarified foot pressure patterns and hindfoot deformities in individuals with advanced knee osteoarthritis (OA) and analyzed their associations with foot pain. Sixty-four individuals with unilateral knee OA who underwent total knee arthroplasty (TKA) were divided into the following groups: no foot pain (n=26; men:women, 4:22; mean age, 73.7 years), foot pain resolved after TKA (12; 2:10; 75.8), and foot pain remaining after TKA (26; 4:22; 74.7). Elderly individuals without pain or deformity in either knee (54; 10:44; 74...
October 6, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28969275/the-relation-between-dermatoglyphics-and-mesiodistal-width-of-the-deciduous-second-molar-and-permanent-first-molar
#3
Naveen Kumar Ramagoni, Vinod Kumar, Hamsini Adusumilli, Km Parveen Reddy, Nh Praveen Kumar
INTRODUCTION: Dermatoglyphics is one of the important diagnostic tools used in the recent days for identification of an individual. Dermatoglyphics is the study of type of patterns present on digits, palms and foot. The mesiodistal diameter of the tooth is an important factor which reveals the tooth-bone discrepancy. Deciduous second molar and permanent first molar exhibit least degree of variation. Both the dermal ridges and the enamel layer of the tooth originate from ectodermal layer and during the same period of intrauterine life...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28934734/correlation-between-foot-arch-index-and-intensity-of-foot-knee-and-low-back-pain-among-pregnant-women-in-a-south-eastern-nigerian-community
#4
Chidiebele Petronilla Ojukwu, Emeka Godson Anyanwu, Ginika Gladys Nwafor
OBJECTIVES: To assess the arch height index of pregnant women and its correlation with foot pain, anterior knee pain and low back pain. SUBJECTS AND METHODS: Two hundred and fifteen (215) consenting pregnant women participated in this cross-sectional study. Arch height index was assessed from their foot prints while pain intensity was rated on a numerical pain rating scale. Data was summarized with descriptive statistics and Pearson's correlation was used to determine correlations between the variables at p<0...
September 19, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28933975/foot-problems-in-older-women
#5
F Guidozzi
Between 20 and 45% of women aged over 65 years of age will develop one or more foot problems, which, although not specific to older women, are more common in that age group than in younger women. These include structural defects of the toes including hallux valgus, hammer, mallet or claw toes, skin disorders, fungal infection of the toes and toe nails, thickened toe nails, ulcers, fissures or cracks between the toes, corns and calluses, flat or high-arched feet. Foot pain is common and may be associated with other co-morbid diseases of the foot...
September 21, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28925669/lower-extremity-abnormalities-in-children
#6
Caitlyn M Rerucha, Caleb Dickison, Drew C Baird
Leg and foot problems in childhood are common causes of parental concern. Rotational problems include intoeing and out-toeing. Intoeing is most common in infants and young children. Intoeing is caused by metatarsus adductus, internal tibial torsion, and femoral anteversion. Out-toeing is less common than intoeing and occurs more often in older children. Out-toeing is caused by external tibial torsion and femoral retroversion. Angular problems include genu varum (bowleg) and genu valgum (knock knee). With pes planus (flatfoot), the arch of the foot is usually flexible rather than rigid...
August 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28902682/the-influence-of-foot-strike-technique-on-the-neuromechanical-function-of-the-foot
#7
Luke A Kelly, Dominic J Farris, Glen A Lichtwark, Andrew G Cresswell
PURPOSE: The aim of this study was to investigate the influence of foot-strike technique on longitudinal arch mechanics and intrinsic foot muscle function during running. METHODS: 13 healthy participants ran barefoot on a force-instrumented treadmill at 2.8ms with a forefoot (FFS) and rear-foot (RFS, habitual) running technique, while kinetic, kinematic and electromyographic (EMG) data from the intrinsic foot muscles were collected simultaneously. The longitudinal arch was modeled as a single "mid-foot" joint representing motion of the rear-foot (calcaneus) relative to the forefoot (metatarsals)...
September 11, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28882059/mri-evaluation-of-ligaments-and-tendons-of-foot-arch-in-talar-dome-osteochondral-lesions
#8
Ali Koç, Özgür Karabiyik
Background There are no publications in literature describing an association between disorders of the ligaments and tendons supporting the foot arch and osteochondral lesions of the talus (OCLT). We believe there may be a correlation between the damage of these structures. Purpose To investigate the pathologies of main ligaments and tendons that support the foot arch in sprained ankles, by reviewing magnetic resonance imaging (MRI) studies and comparing the results in two groups of patients, with and without OCLT...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28877185/feet-deformities-are-correlated-with-impaired-balance-and-postural-stability-in-seniors-over-75
#9
Ewa Puszczalowska-Lizis, Przemyslaw Bujas, Jaroslaw Omorczyk, Slawomir Jandzis, Marek Zak
OBJECTIVE: Understanding the factors and mechanisms that determine balance in seniors appears vital in terms of their self-reliance and overall safety. The study aimed to determine the relationship between the features of feet structure and the indicators of postural stability in the elderly. METHODS: The study group comprised 80 seniors (41F, 39M; aged 75-85 years). CQ-ST podoscope and the CQ-Stab 2P two-platform posturograph were used as primary research tools...
2017: PloS One
https://www.readbyqxmd.com/read/28876565/pattern-and-distribution-of-peripheral-arterial-disease-in-diabetic-patients-with-critical-limb-ischemia-rutherford-clinical-category-4-6
#10
M J Motsumi, N G Naidoo
BACKGROUND: This study investigated the pattern and distribution of peripheral arterial disease in diabetic patients with critical limb ischaemia (CLI) and to stratify the findings according to the patients' risk factor profile, gender and age group. METHOD: We conducted a one-year prospective descriptive study (January 2014 to December 2014) at Groote Schuur Hospital, University of Cape Town. The research protocol and the informed consent were approved by the Institutional Review Board, and all subjects included in this study gave an informed consent...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28871902/height-of-the-medial-longitudinal-arch-during-classical-ballet-steps
#11
Carolina Cabral de Mello Viero, Luíza Pillar Kessler, Camila Pinto, Kaanda Nabilla Souza Gontijo, Rodrigo Gomes da Rosa, Ana Kleiner, Leonardo Alexandre Peyré-Tartaruga, Alexandre Severo do Pinho, Aline de Souza Pagnussat
The purpose of this study was to evaluate the midfoot longitudinal arch height and correlate it with active hip external rotation (ER) in dancers during static postures and technical steps of classical ballet (i.e., first position, demi-plié, battement fondu à la seconde, pas jeté à la seconde, and grand jeté à la seconde). A 3D motion analysis system was used for kinematic analysis. The arch height was significantly reduced during the battement fondu à la seconde, pas jeté à la seconde, and grand jeté à la seconde when compared to standing (p = 0...
September 15, 2017: Journal of Dance Medicine & Science
https://www.readbyqxmd.com/read/28840674/-case-report-comprehensive-treatment-of-forefoot-with-double-brachymetatarsia-in-one-surgical-stage
#12
I Caldiño-Lozada, O Gallegos-de la Torre, R Esperón-Hernández
Brachymetatarsia (shortening of the metatarsal) directly affects the transversal arch of the foot causing severe deformities, such as hallux valgus, divergent toes, overlapping toes, metatarsalgia, all of these alter the biomechanics of the foot and gait. Treatment consists of two main techniques, one-stage lengthening with bone graft or elongation through callotaxis with external fixator; there are variants of both techniques used to minimize the disadvantages of each. The objective of treatment must be to return the structural harmony to the forefoot, improving the biomechanics, resulting in a satisfactory outcome for the patients...
March 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28839522/the-thermoregulation-of-healthy-individuals-overweight-obese-and-diabetic-from-the-plantar-skin-thermogram-a-clue-to-predict-the-diabetic-foot
#13
REVIEW
Francisco-J Renero-C
Background: Thermoregulation is a complex autonomic process to keep or to dissipate heat in the human body. Methods: In this work, by means of the thermogram of the plantar skin, the thermoregulation of healthy individuals, overweight-obese, and diabetic is discussed. Results: The thermograms of the plantar skin, for the healthy individuals, are: (1) symmetrical, the temperature distribution of the right foot being a mirror image of that of the left foot ; (2) the thermograms of women, on average, are 3°C colder than those of the men; and (3) the temperature distributions decrease distally from the medial longitudinal arch...
2017: Diabetic Foot & Ankle
https://www.readbyqxmd.com/read/28814975/the-typically-developing-paediatric-foot-how-flat-should-it-be-a-systematic-review
#14
REVIEW
Hayley Uden, Rolf Scharfbillig, Ryan Causby
BACKGROUND: All typically developing children are born with flexible flat feet, progressively developing a medial longitudinal arch during the first decade of their lives. Whilst the child's foot is expected to be flat, there is currently no consensus as to how flat this foot should be. Furthermore, whilst feet are observed to decrease in flatness with increasing age, it is not known how flat they should be at each age increment. The objective of this systematic review is to define the postural characteristics of the 'typically' developing paediatric foot...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28808276/growing-up-habitually-barefoot-influences-the-development-of-foot-and-arch-morphology-in-children-and-adolescents
#15
Karsten Hollander, Johanna Elsabe de Villiers, Susanne Sehner, Karl Wegscheider, Klaus-Michael Braumann, Ranel Venter, Astrid Zech
The development of the human foot is crucial for motor learning in children and adolescents as it ensures the basic requirements for bipedal locomotion and stable standing. Although there is an ongoing debate of the advantages and disadvantages of early and permanent footwear use, the influence of regular barefootness on foot characteristics in different stages of child development has not been extensively evaluated. A multicenter epidemiological study was conducted to compare the foot morphology between habitually barefoot children and adolescents (N = 810) to age-, sex- and ethnicity-matched counterparts that are used to wearing shoes...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28783556/foot-structure-is-significantly-associated-to-subtalar-joint-kinetics-and-mechanical-energetics
#16
Jayishni N Maharaj, Andrew G Cresswell, Glen A Lichtwark
INTRODUCTION/AIM: Foot structure has been implicated as a risk factor of numerous overuse injuries, however, the mechanism linking foot structure and the development of soft-tissue overuse injuries are not well understood. The aim of this study was to identify factors that could predict foot function during walking. METHODS: A total of eleven variables (including measures of foot structure, anthropometry and spatiotemporal gait characteristics) were investigated for their predictive ability on identifying kinematic, kinetic and energetic components of the foot...
October 2017: Gait & Posture
https://www.readbyqxmd.com/read/28779804/what-to-do-with-the-spring-ligament
#17
REVIEW
Brian Steginsky, Anand Vora
The spring ligament complex is an important static restraint of the medial longitudinal arch of the foot and its failure has been associated with progressive flatfoot deformity. Reconstruction of the spring ligament complex is most appropriate in stage II posterior tibial tendon dysfunction, before severe peritalar subluxation and rigid deformity develops. Although an understanding of the spring ligament complex and its contribution to medial arch stability has grown, there is no unanimously accepted surgical technique that has consistently demonstrated satisfactory outcomes...
September 2017: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/28777349/a-foot-arch-parameter-measurement-system-using-a-rgb-d-camera
#18
Sungkuk Chun, Sejin Kong, Kyung-Ryoul Mun, Jinwook Kim
The conventional method of measuring foot-arch parameters is highly dependent on the measurer's skill level, so accurate measurements are difficult to obtain. To solve this problem, we propose an autonomous geometric foot-arch analysis platform that is capable of capturing the sole of the foot and yields three foot-arch parameters: arch index (AI), arch width (AW) and arch height (AH). The proposed system captures 3D geometric and color data on the plantar surface of the foot in a static standing pose using a commercial RGB-D camera...
August 4, 2017: Sensors
https://www.readbyqxmd.com/read/28777274/a-long-term-follow-up-of-young-adults-with-idiopathic-clubfoot-does-foot-morphology-relate-to-pain
#19
Adam N Graf, Ken N Kuo, Nikhil T Kurapati, Joseph J Krzak, Sahar Hassani, Angela K Caudill, Ann Flanagan, Gerald F Harris, Peter A Smith
BACKGROUND: Individuals with clubfoot, treated in infancy with either the Ponseti method or comprehensive clubfoot release, often encounter pain as adults. Multiple studies have characterized residual deformity after Ponseti or surgical correction using physical exam, radiographs and pedobarography; however, the relationship between residual foot deformity and pain is not well defined. The purpose of the current study was 2-fold: (1) to evaluate the relationship between foot morphology and pain for young adults treated as infants for idiopathic clubfoot and (2) to describe and compare pedobarographic measures and outcome measures of pain and morphology among surgically treated, Ponseti treated, and typically developing feet...
August 2, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28770006/categorisation-of-foot-complaints-in-systemic-lupus-erythematosus-sle-from-a-new-zealand-cohort
#20
Simon J Otter, Maheswaran Rohan, Kevin A Davies, Sunil Kumar, Peter Gow, Nicola Dalbeth, Michael Corkill, Sam Panthakalam, Keith Rome
BACKGROUND: Foot complaints have been shown to be common in systemic lupus erythematosus (SLE) and heterogeneous in nature. We aimed to categorize self-reported foot complaints in people with SLE and foot symptoms. METHODS: A self-administered validated questionnaire was posted to 406 people with SLE attending adult rheumatology clinics across three health boards in Auckland, New Zealand. In addition to foot pain, vascular complaints, dermatological lesions and neurological symptoms were included in the analysis...
2017: Journal of Foot and Ankle Research
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