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Cell siganlling

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https://www.readbyqxmd.com/read/29423271/dual-roles-of-endothelial-fgf-2-fgfr1-pdgf-bb-and-perivascular-fgf-2-fgfr2-pdgfr%C3%AE-signaling-pathways-in-tumor-vascular-remodeling
#1
Kayoko Hosaka, Yunlong Yang, Masaki Nakamura, Patrik Andersson, Xiaojuan Yang, Yin Zhang, Takahiro Seki, Martin Scherzer, Olivier Dubey, Xinsheng Wang, Yihai Cao
Perivascular cells are important cellular components in the tumor microenvironment (TME) and they modulate vascular integrity, remodeling, stability, and functions. Here we show using mice models that FGF-2 is a potent pericyte-stimulating factor in tumors. Mechanistically, FGF-2 binds to FGFR2 to stimulate pericyte proliferation and orchestrates the PDGFRβ signaling for vascular recruitment. FGF-2 sensitizes the PDGFRβ signaling through increasing PDGFRβ levels in pericytes. To ensure activation of PDGFRβ, the FGF-2-FGFR1-siganling induces PDGF-BB and PDGF-DD, two ligands for PDGFRβ, in angiogenic endothelial cells...
2018: Cell Discovery
https://www.readbyqxmd.com/read/27800305/notch-signaling-contributes-to-liver-inflammation-by-regulation-of-interleukin-22-producing-cells-in-hepatitis-b-virus-infection
#2
Xin Wei, Jiu-Ping Wang, Chun-Qiu Hao, Xiao-Fei Yang, Lin-Xu Wang, Chang-Xing Huang, Xue-Fan Bai, Jian-Qi Lian, Ye Zhang
The mechanism of hepatitis B virus (HBV) induced liver inflammation is not fully elucidated. Notch signaling augmented interleukin (IL)-22 secretion in CD4(+) T cells, and Notch-IL-22 axis fine-tuned inflammatory response. We previously demonstrated a proinflammatory role of IL-22 in HBV infection. Thus, in this study, we analyzed the role of Notch in development of IL-22-producing cells in HBV infection by inhibition of Notch signaling using γ-secretase inhibitor DAPT in both hydrodynamic induced HBV-infected mouse model and in peripheral blood cells isolated from patients with HBV infection...
2016: Frontiers in Cellular and Infection Microbiology
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