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https://www.readbyqxmd.com/read/29778715/photopheresis-of-a-less-than-10-kg-child-with-acute-graft-versus-host-disease-accompanied-with-hyperbilirubinemia-a-case-report
#1
REVIEW
Ashraf Malek Mohammadi, Amir Hossein Norooznezhad, Jerard Seghatchian, Mohsen Nikbakht, Farhad Heshmati, Saeed Mohammadi, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
Hematopoietic stem cell transplantation is a curative treatment for many hematologic malignancies with its most important side effect being graft-versus-host disease (GVHD). Herein, we present a 3.5 year-old male with weight of 9.8 kg with acute GVHD (grade IV gastrointestinal and cutaneous) who did not respond to the first line therapies (corticosteroids). Thus, the patient was a candidate for extracorporeal photochemotherapy (ECP). Due to the hyperbilirubinemia, two sessions of ECP every week as well as one session of plasmapheresis 24 h before each ECP session were performed (Spectra™ Optia® apheresis system)...
May 9, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29774199/malignant-metastasis-misdiagnosed-as-osteoporotic-compression-fracture-a-case-report
#2
Seul Gi Kim, Chang Il Ju, Hui Sun Wang, Seok Won Kim
In cases of vertebral collapse after a trivial injury in elderly patients with severe osteoporosis, it can be a diagnostic challenge to determine whether the cause is a benign compression fracture or malignant metastasis. A 78-year-old male patient was referred to the emergency department for the evaluation of weakness of the left lower limb. He had undergone percutaneous vertebroplasty four months earlier after being diagnosed with L3 osteoporotic compression fracture. He was treated with foraminotomy at the L3-4 level after being diagnosed with foraminal stenosis two months earlier at a spine clinic...
April 2018: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29730783/tissue-indices-of-telomere-length-and-p53-in-patients-with-different-gastrointestinal-tumors-correlation-with-clinicopathological-status
#3
Hala M ElBadre, Reham I El-Mahdy, Nahed A Mohamed, Madeha M Zakhary, Doaa W Maximous
Telomere length dysfunction is involved in the generation of genomic rearrangements that drive progression to malignancy. A set of serological markers for telomere dysfunction, namely chitinase and N-acetylglucosaminidase (NAG), DNA damage, and tissue alteration of p53 have been identified. The probability that genomic damage, accumulation of reactive oxygen species, and shorter telomeres may be related to the onset and advancement of gastrointestinal (GI) tumors. A total of 40 patients with GI tumors and 20 healthy controls with matched age and sex were included...
May 5, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29705263/previous-use-of-anti-thrombotic-agents-reduces-mortality-and-length-of-hospital-stay-in-patients-with-high-risk-upper-gastrointestinal-bleeding
#4
Philip Dj Dunne, Stig B Laursen, Loren Laine, Harry R Dalton, Jing H Ngu, M Schultz, Adam Rahman, Andrea Anderloni, Iain A Murray, Adrian J Stanley
BACKGROUND AND AIMS: Anti-thrombotic agents are risk factors for upper gastrointestinal bleeding (UGIB). However, few studies have evaluated their effects on patient outcomes. We assessed the effects of anti-thrombotic agents on outcomes of patients with high-risk UGIB. METHODS: We performed a prospective study of 619 patients with acute UGIB (defined by hematemesis, coffee-ground vomit or melena) who required intervention and underwent endoscopy at 8 centers in North America, Asia, and Europe, from March 2014 through March 2015...
April 26, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29703758/immune-checkpoint-inhibitor-induced-gastrointestinal-and-hepatic-injury-pathologists-perspective
#5
REVIEW
Dipti M Karamchandani, Runjan Chetty
Immune checkpoint inhibitors (CPIs) are a relatively new class of 'miracle' dugs that have revolutionised the treatment and prognosis of some advanced-stage malignancies, and have increased the survival rates significantly. This class of drugs includes cytotoxic T lymphocyte antigen-4 inhibitors such as ipilimumab; programmed cell death protein-1 inhibitors such as nivolumab, pembrolizumab and avelumab; and programmed cell death protein ligand-1 inhibitors such as atezolizumab. These drugs stimulate the immune system by blocking the coinhibitory receptors on the T cells and lead to antitumoural response...
April 27, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29669540/predictive-values-of-upper-gastrointestinal-cancer-alarm-symptoms-in-the-general-population-a-nationwide-cohort-study
#6
Sanne Rasmussen, Peter Fentz Haastrup, Kirubakaran Balasubramaniam, René DePont Christensen, Jens Søndergaard, Dorte Ejg Jarbøl
BACKGROUND: Survival rates for upper gastrointestinal (GI) cancer are poor since many are diagnosed at advanced stages. Fast track endoscopy has been introduced to prompt diagnosis for patients with alarm symptoms that could be indicative of upper GI cancer. However, these symptoms may represent benign conditions and little is known about the predictive values of alarm symptoms of upper GI cancer in the general population. METHODS: The study is a nationwide cohort study of 60,562 individuals aged 45 years or above randomly selected from the Danish general population...
April 18, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29607447/oropharyngeal-dysphagia-evaluation-tools-in-adults-with-solid-malignancies-outside-the-head-and-neck-and-upper-gi-tract-a-systematic-review
#7
REVIEW
Ciarán Kenny, Órla Gilheaney, Declan Walsh, Julie Regan
Dysphagia is often associated with head and neck and upper gastrointestinal (GI) tract cancers. Evidence suggests that those with solid malignancies in other primary sites may also have swallowing difficulties. Timely and accurate identification of dysphagia is important given the impact it has on hydration, medical treatment, nutrition, prognosis, and quality of life. A systematic review was conducted to identify swallow screening, evaluation, and quality of life tools for those with solid malignancies outside the head and neck and upper GI tract...
April 2, 2018: Dysphagia
https://www.readbyqxmd.com/read/29598887/expression-of-programmed-cell-death-1-programmed-cell-death-ligand-1-in-the-tumor-microenvironments-of-primary-gastrointestinal-diffuse-large-b-cell-lymphomas
#8
Yang Liu, Jing Ma, Kangjie Yu, Mingyang Li, Fang Liu, Qingguo Yan, Zhe Wang, Shuangping Guo
BACKGROUND: Gastrointestinal diffuse large B cell lymphoma (GI DLBCL) is the most common gastrointestinal lymphoma. However, there has not been a comprehensive investigation into the expression patterns of programmed cell death 1 (PD-1) and programmed cell death ligand 1(PD-L1) in GI DLBCL tissues. METHODS: PD-1 protein expression in tumor-infiltrating lymphocytes (TILs) was evaluated by immunohistochemical staining, and expression of PD-L1 was evaluated by using PD-L1/PAX5 immunohistochemical double staining in 92 GI DLBCL specimens...
March 12, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29582639/diagnostic-value-of-glypican-3-for-hepatocellular-carcinomas
#9
Sherif El-Saadany, Taher El-Demerdash, Amal Helmy, Wael Wahid Mayah, Boshra El-Sayed Hussein, Mohammed Hassanien, Nehal Elmashad, Mahmoud Ali Fouad, Eman Ahmed Basha
Background: Hepatocellular carcinoma (HCC) is a common and dangerous malignancy in many parts of the world, and especially in Egypt. Early diagnosis is the most important step in successful HCC management. However most cases are detected at late stage making effective intervention impossible. Aim: The aim of this study was to evaluate the potential of Glypican-3 (GPC-3) to aid in diagnosis of HCC, especially in patients with low serum alpha-fetoprotein (AFP). Subjects and methods: Serum GPC-3 was assessed by flow-cytometry and serum AFP by enzyme-linked immunosorbent assay (ELISA) in 40 HCC patients with AFP< 400ug\l...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29566903/the-gastrointestinal-microbiota-and-its-role-in-oncogenesis
#10
REVIEW
S Y Lam, J Yu, S H Wong, M P Peppelenbosch, G M Fuhler
Advances in research techniques have made it possible to map the microbial communities in the gastrointestinal (GI) tract, where the majority of bacteria in the human body reside. Disturbances in these communities are referred to as dysbiosis and have been associated with GI cancers. Although dysbiosis is observed in several GI malignancies, the specific role of these changes has not been understood to the extent of Helicobacter pylori (HP) in gastric cancer (GC). This review will address the bacterial communities along the GI tract, from the oral cavity to the anal canal, particularly focusing on bacterial dysbiosis and carcinogenesis...
December 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/29536052/a-cross-sectional-analysis-of-long-term-immunosuppressive-regimens-after-liver-transplantation-at-asan-medical-center-increased-preference-for-mycophenolate-mofetil
#11
Shin Hwang, Chul-Soo Ahn, Ki-Hun Kim, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung, Gil-Chun Park, Sung-Gyu Lee
Backgrounds/Aims: Long-term immunosuppression regimens after liver transplantation (LT) are rarely reported in detail. We aimed to provide information on actual long-term immunosuppression regimens through this cross-sectional study. Methods: Our institutional LT database was searched for adult patients who underwent primary LT operation from 2000 to 2016. We identified 3620 live recipients with actual information on immunosuppressive agent use for 1-17 years. Results: The study cohort was divided into 7 groups according to posttransplantation period...
February 2018: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/29528991/whole-recombinant-saccharomyces-cerevisiae-yeast-expressing-ras-mutations-as-treatment-for-patients-with-solid-tumors-bearing-ras-mutations-results-from-a-phase-1-trial
#12
Allen Cohn, Michael A Morse, Bert O'Neil, Samuel Whiting, Claire Coeshott, John Ferraro, Donald Bellgrau, David Apelian, Timothy C Rodell
We are developing whole, heat-killed, recombinant Saccharomyces cerevisiae yeast, engineered to encode target proteins, which stimulate immune responses against malignant cells expressing those targets. This phase 1 trial, enrolling patients with advanced colorectal or pancreas cancer, was designed to evaluate safety, immunogenicity, response, and overall survival of ascending doses of the GI-4000 series of products, which express 3 different forms of mutated Ras proteins. The study enrolled 33 heavily pretreated subjects (14 with pancreas and 19 with colorectal cancer), whose tumors were genotyped before enrollment to identify the specific ras mutation and thereby to identify which GI-4000 product to administer...
April 2018: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29524855/melena-as-an-unusual-presentation-of-gastrointestinal-stromal-tumour-a-case-report
#13
G Mulkerrin, N M Hogan, M Sheehan, M R Joyce
INTRODUCTION: Gastrointestinal Stromal Tumors (GISTs) are a rare slow growing malignancy, accounting for less than 1% of all gastrointestinal (GI) tract tumors. These tumors are usually discovered incidentally by endoscopy, surgery or radiology. However on occasions they may present with significant symptoms including GI blood loss. This case report discusses an atypical presentation of a GIST in a 57-year-old female. CASE PRESENTATION: A 57-year-old woman presented to the emergency department following one episode of melena...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29520180/double-stent-system-with-long-duodenal-extension-for-palliative-treatment-of-malignant-extrahepatic-biliary-obstructions-a-prospective-study
#14
Dong Il Gwon, Gi-Young Ko, Jong Woo Kim, Heung Kyu Ko, Hyun-Ki Yoon, Kyu-Bo Sung
Objective: To investigate the technical safety and clinical efficacy of a double-stent system with long duodenal extension in patients with malignant extrahepatic biliary obstruction. Materials and Methods: This prospective study enrolled 48 consecutive patients (31 men, 17 women; mean age, 61 years; age range, 31-77 years) with malignant extrahepatic biliary obstructions from May 2013 to December 2015. All patients were treated with a double-stent system with long duodenal covered extension (16 cm or 21 cm)...
March 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29478825/early-postoperative-and-late-metabolic-morbidity-after-pancreatic-resections-an-old-and-new-challenge-for-surgeons-a-review
#15
REVIEW
Hans G Beger, Benjamin Mayer
The metrics for measuring early postoperative morbidity after resection of pancreatic neoplastic tumors are overall morbidity, severe surgery-related morbidity, frequency of reoperation and reintervention, in-hospital, 30-day and 90-day mortality and length of hospital stay. Thirty-day readmission after discharge is additionally an indispensable criterion to assess quality of surgery. The metrics for surgery-associated long-term results after pancreatic resections are survival times, new onset of diabetes (DM), impaired glucose tolerance, exocrine pancreatic insufficiency, body mass index and GI motility dysfunctions...
February 16, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29477437/simultaneous-detection-and-classification-of-breast-masses-in-digital-mammograms-via-a-deep-learning-yolo-based-cad-system
#16
Mohammed A Al-Masni, Mugahed A Al-Antari, Jeong-Min Park, Geon Gi, Tae-Yeon Kim, Patricio Rivera, Edwin Valarezo, Mun-Taek Choi, Seung-Moo Han, Tae-Seong Kim
BACKGROUND AND OBJECTIVE: Automatic detection and classification of the masses in mammograms are still a big challenge and play a crucial role to assist radiologists for accurate diagnosis. In this paper, we propose a novel Computer-Aided Diagnosis (CAD) system based on one of the regional deep learning techniques, a ROI-based Convolutional Neural Network (CNN) which is called You Only Look Once (YOLO). Although most previous studies only deal with classification of masses, our proposed YOLO-based CAD system can handle detection and classification simultaneously in one framework...
April 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29466074/prevalence-and-survival-impact-of-pretreatment-cancer-associated-weight-loss-a-tool-for-guiding-early-palliative-care
#17
Bhavani S Gannavarapu, Steven K M Lau, Kristen Carter, Nathan A Cannon, Ang Gao, Chul Ahn, Jeffrey J Meyer, David J Sher, Aminah Jatoi, Rodney Infante, Puneeth Iyengar
PURPOSE: Cancer-associated weight loss is associated with poor prognosis in advanced malignancy; however, its pretreatment prevalence and survival impact are inadequately described in large cohorts. Such data, stratified by tumor type and stage, may facilitate the optimal and timely allocation of complementary care, leading to improvements in patient survival and quality of life. METHODS: We performed a retrospective cohort study of 3,180 consecutively treated adult patients with lung or GI (including colorectal, liver, and pancreatic) cancer...
April 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29457119/effects-of-glucose-insulin-infusion-during-major-oral-and-maxillofacial-surgery-on-postoperative-complications-and-outcomes
#18
Akina Tohya, Atsushi Kohjitani, Sachi Ohno, Kaoru Yamashita, Yozo Manabe, Mitsutaka Sugimura
Background: Secretion of hormones, which antagonize the action of insulin, is facilitated in response to surgery, and acute resistance to the action of insulin develops. Our aim is to elucidate the effects of intraoperative glycemic control by glucose-insulin (GI) infusion on postoperative complications and outcomes in major oral and maxillofacial surgery. Findings: Thirty patients aged ≥ 60 years undergoing a radical operation of oral malignant tumors with tissue reconstruction (≥ 8 h) were analyzed...
2018: JA Clinical Reports
https://www.readbyqxmd.com/read/29448806/endovascular-treatment-for-the-control-of-active-vaginal-bleeding-from-uterine-cervical-cancer-treated-with-radiotherapy
#19
Cheng Shi Chen, Sohee Park, Ji Hoon Shin, Yasir Nouri, Jong-Woo Kim, Hyun-Ki Yoon, Gi-Young Ko
Background Endovascular treatment has become a significant therapeutic option for the management of intractable bleeding in gynecologic malignancies. However, the endovascular treatment types were almost never mentioned when active bleeding from different arteries was identified. Purpose To present angiographic details and evaluate clinical efficacy of endovascular treatments to control active vaginal bleeding in uterine cervical cancer patients treated with radiotherapy. Material and Methods In this retrospective study, six, consecutive cervical cancer patients treated with radiotherapy who underwent endovascular treatment for active vaginal bleeding were included...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29413710/comparing-the-geographic-distribution-and-location-characteristics-of-hiv-seropositive-and-hiv-seronegative-individuals-with-a-diagnosis-of-cancer-living-in-the-southeast-us
#20
Benjamin D Hallowell, Sara W Robb, Kristina W Kintziger
As HIV-seropositive individuals live longer, they are more likely to acquire conditions seen in the general population. Excluding AIDS-defining malignancies, HIV-seropositive individuals are more likely to develop cancer than individuals in the general population. In order to better inform future screening and prevention efforts in this population, we compared the geographic distribution and location characteristics of HIV-seropositive and HIV-seronegative cancer cases in South Carolina (SC). To do this we obtained linked HIV and cancer data from the SC enhanced HIV/AIDS Reporting System and Central Cancer Registry...
February 2018: Spatial and Spatio-temporal Epidemiology
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