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Coconut oil AND diabetes

Annie E Newell-Fugate, Katherine Lenz, Cassandra Skenandore, Romana A Nowak, Bryan A White, Andrea Braundmeier-Fleming
Forty percent of American women are obese and at risk for type II diabetes, impaired immune function, and altered microbiome diversity, thus impacting overall health. We investigated whether obesity induced by an excess calorie, high fat diet containing hydrogenated fats, fructose, and coconut oil (HFD) altered glucose homeostasis, peripheral immunity, and urogenital microbial dynamics. We hypothesized that HFD would cause hyperglycemia, increase peripheral inflammation, and alter urogenital microbiota to favor bacterial taxonomy associated with inflammation...
2017: PloS One
Laura A Velázquez-Villegas, Claudia Tovar-Palacio, Berenice Palacios-González, Nimbe Torres, Armando R Tovar, Andrea Díaz-Villaseñor
SCOPE: Hyperglucagonemia contributes to hyperglycemia in type 2 diabetes (T2D). Previously, we have found that soy protein normalized fasting hyperglucagonemia in obese Zucker (fa/fa) rats, sensitizing the HSL-lipolytic signaling pathway in white adipose tissue (WAT), however the mechanism remains unknown. METHODS AND RESULTS: Zucker (fa/fa) rats were fed casein or soy protein diet in combination with soybean or coconut oil. Glucagon receptor (GR) was increased at the plasma membrane of adipocytes of rats fed soy protein compared to those fed casein, without changes in total GR abundance...
June 27, 2017: Molecular Nutrition & Food Research
Mazhar Hussian, Abdul Qudoos Arain, Sadia Chiragh
OBJECTIVE: To evaluate the anti-dyslipidaemic effects of pioglitazone in diet-induced non-diabetic hyperlipidaemic rats and to compare them with gemfibrozil. METHODS: This comparative animal study was conducted at the Postgraduate Medical Institute, Lahore, Pakistan, from July to September 2011, and comprised Sprague Dawley albino rats divided into three equal groups. Initially all three groups were given high-lipid diet containing cholesterol 1.5g, coconut oil 8ml and sodium cholate 1...
October 2016: JPMA. the Journal of the Pakistan Medical Association
Iván Hu Yang, Jose Enrique De la Rubia Ortí, Pablo Selvi Sabater, Sandra Sancho Castillo, Mariano Julián Rochina, Noemí Manresa Ramón, Inmaculada Montoya-Castilla
BACKGROUND: Alzheimer's dementia is the most prevalent nowadays. As for treatment, there is no definitive cure drug, thus new therapies are needed. In this regard the medium chain triglycerides are a direct source of cellular energy and can be a nonpharmacological alternative to the neuronal death for lack of it, that occurs in Alzheimer patients. OBJECTIVE: to evaluate the impact of coconut oil in the development of Alzheimer's dementia, in any degree of dementia...
December 1, 2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Poonamjot Deol, Jane R Evans, Joseph Dhahbi, Karthikeyani Chellappa, Diana S Han, Stephen Spindler, Frances M Sladek
The obesity epidemic in the U.S. has led to extensive research into potential contributing dietary factors, especially fat and fructose. Recently, increased consumption of soybean oil, which is rich in polyunsaturated fatty acids (PUFAs), has been proposed to play a causal role in the epidemic. Here, we designed a series of four isocaloric diets (HFD, SO-HFD, F-HFD, F-SO-HFD) to investigate the effects of saturated versus unsaturated fat, as well as fructose, on obesity and diabetes. C57/BL6 male mice fed a diet moderately high in fat from coconut oil and soybean oil (SO-HFD, 40% kcal total fat) showed statistically significant increases in weight gain, adiposity, diabetes, glucose intolerance and insulin resistance compared to mice on a diet consisting primarily of coconut oil (HFD)...
2015: PloS One
W M A D B Fernando, Ian J Martins, K G Goozee, Charles S Brennan, V Jayasena, R N Martins
Coconut, Cocos nucifera L., is a tree that is cultivated to provide a large number of products, although it is mainly grown for its nutritional and medicinal values. Coconut oil, derived from the coconut fruit, has been recognised historically as containing high levels of saturated fat; however, closer scrutiny suggests that coconut should be regarded more favourably. Unlike most other dietary fats that are high in long-chain fatty acids, coconut oil comprises medium-chain fatty acids (MCFA). MCFA are unique in that they are easily absorbed and metabolised by the liver, and can be converted to ketones...
July 14, 2015: British Journal of Nutrition
Fazal Shirazi, Dimitrios Farmakiotis, Yuanqing Yan, Nathaniel Albert, Kim-Anh Do, Do Kim-Anh, Dimitrios P Kontoyiannis
In an experimental model of obesity and hyperglycemia in Drosophila melanogaster we studied the effect of diet modification and administration of metformin on systemic infection with Rhizopus, a common cause of mucormycosis in diabetic patients. Female Wt-type Drosophila flies were fed regular (RF) or high-fat diet (HFD; 30% coconut oil) food with or without metformin for 48 h and then injected with R. oryzae. Survival rates, glucose and triglyceride levels were compared between 1) normal-weight flies (RF), 2) obese flies (HFD), 3) obese flies fed with RF, 4) flies continuously fed on HFD + metformin, 5) flies fed on HFD + metformin, then transferred to RF, and 6) obese flies administered metformin after infection [corrected]...
2014: PloS One
He Sun, Tao Jiang, Shubao Wang, Bing He, Yongyan Zhang, Dongxu Piao, Chong Yu, Na Wu, Ping Han
AIMS: We aimed to investigate the effects of LXRα, ChREBP and Elovl6 in the development of insulin resistance-induced by medium- and long-chain fatty acids. METHODS: Sprague Dawley rats were fed a standard chow diet (Control group) or a high-fat, high sucrose diet with different fat sources (coconut oil, lard, sunflower and fish oil) for 8 weeks. These oils were rich in medium-chain saturated fatty acids (MCFA group), long-chain saturated fatty acids (LCFA group), n-6 and n-3 long-chain polyunsaturated fatty acids (n-6 PUFA and n-3 PUFA groups), respectively, which had different chain lengths and degrees of unsaturation...
December 2013: Diabetes Research and Clinical Practice
Anna Pietraszek, Kjeld Hermansen, Steen B Pedersen, Bente L Langdahl, Jens J Holst, Søren Gregersen
OBJECTIVE: Patients with type 2 diabetes and their relatives (REL) have increased risk for cardiovascular disease (CVD). Postprandial triglyceridemia (PPL), which is influenced by diet, is an independent risk factor for CVD. Little is known about the effects of medium-chain saturated fatty acids (medium-chain SFA) on PPL and gene expression in REL. The objective of this study was to test the hypothesis that medium-chain SFA cause larger PPL response in REL compared with controls (CON) and have a differential effect on circulating incretins and ghrelin and gene expression in muscle and adipose tissue in REL and CON...
July 2013: Nutrition
Venkatesh Mani, James H Hollis, Nicholas K Gabler
UNLABELLED: HASH(0x3481b60) BACKGROUND: Intestinal derived endotoxin and the subsequent endotoxemia can be considered major predisposing factors for diseases such as atherosclerosis, sepsis, obesity and diabetes. Dietary fat has been shown to increase postprandial endotoxemia. Therefore, the aim of this study was to assess the effects of different dietary oils on intestinal endotoxin transport and postprandial endotoxemia using swine as a model. We hypothesized that oils rich in saturated fatty acids (SFA) would augment, while oils rich in n-3 polyunsaturated fatty acids (PUFA) would attenuate intestinal endotoxin transport and circulating concentrations...
2013: Nutrition & Metabolism
P Sabitha, Kannan Vaidyanathan, D M Vasudevan, Prakash Kamath
In this study, we compared the lipid profile and antioxidant enzymes of normal and diabetic subjects consuming two different types of oil as cooking medium. 70 normal, healthy subjects were taken as controls and 70 subjects with Type 2 diabetes were recruited in patient group. Each group was further subdivided into two subgroups of 35 subjects each, consuming coconut oil and sunflower oil respectively as cooking medium. Samples of blood were collected and analyzed for serum total cholesterol, triacylglycerols, and cholesterol in lipoprotein fractions...
January 2009: Indian Journal of Clinical Biochemistry: IJCB
Shastri Motilal, Rohan G Maharaj
OBJECTIVES: Current treatment strategies for painful diabetic neuropathy (PDN) include oral medications, which are costly and may have adverse effects. Topical therapies have been used for PDN with some benefit. Nutmeg has certain properties that may be effective in ameliorating neuropathic pain. The purpose of this study was to determine whether topical nutmeg extracts can reduce pain or improve the quality of life in PDN sufferers. DESIGN: This study was a randomized, double-blind, placebo-controlled trial...
April 2013: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
John F Trepanowski, Mohammad M Kabir, Rick J Alleman, Richard J Bloomer
UNLABELLED: HASH(0x3a0eca8) BACKGROUND: The Daniel Fast is a vegan diet that prohibits the consumption of animal products, refined foods, white flour, preservatives, additives, sweeteners, flavorings, caffeine, and alcohol. Following this dietary plan for 21 days has been demonstrated to improve blood pressure, LDL-C, and certain markers of oxidative stress, but it has also been shown to lower HDL-C. Krill oil supplementation has been shown to increase HDL-C. METHODS: We investigated the effects of following a Daniel Fast dietary plan with either krill oil supplementation (2 g/day) or placebo supplementation (coconut oil; 2 g/day) for 21 days...
September 13, 2012: Nutrition & Metabolism
Manisha DebMandal, Shyamapada Mandal
Coconut, Cocos nucifera L., is a tree that is cultivated for its multiple utilities, mainly for its nutritional and medicinal values. The various products of coconut include tender coconut water, copra, coconut oil, raw kernel, coconut cake, coconut toddy, coconut shell and wood based products, coconut leaves, coir pith etc. Its all parts are used in someway or another in the daily life of the people in the traditional coconut growing areas. It is the unique source of various natural products for the development of medicines against various diseases and also for the development of industrial products...
March 2011: Asian Pacific Journal of Tropical Medicine
Ricardo K Yamazaki, Gleisson A P Brito, Isabela Coelho, Danielle C T Pequitto, Adriana A Yamaguchi, Gina Borghetti, Dalton Luiz Schiessel, Marcelo Kryczyk, Juliano Machado, Ricelli E R Rocha, Julia Aikawa, Fabiola Iagher, Katya Naliwaiko, Ricardo A Tanhoffer, Everson A Nunes, Luiz Claudio Fernandes
BACKGROUND: Obesity is commonly associated with diabetes, cardiovascular diseases and cancer. The purpose of this study was to determinate the effect of a lower dose of fish oil supplementation on insulin sensitivity, lipid profile, and muscle metabolism in obese rats. METHODS: Monosodium glutamate (MSG) (4 mg/g body weight) was injected in neonatal Wistar male rats. Three-month-old rats were divided in normal-weight control group (C), coconut fat-treated normal weight group (CO), fish oil-treated normal weight group (FO), obese control group (Ob), coconut fat-treated obese group (ObCO) and fish oil-treated obese group (ObFO)...
2011: Lipids in Health and Disease
L R Freeman, B J Small, P C Bickford, C Umphlet, A-Ch Granholm
A diet containing high levels of saturated fat and cholesterol is detrimental to many aspects of health and is known to lead to obesity, metabolic syndrome, heart disease, diabetes, and cancer. However, the effects of a diet rich in saturated fat and cholesterol on the brain are not currently well understood. In order to determine direct effects of a high saturated fat and cholesterol diet upon fetal hippocampal tissue, we transplanted hippocampal grafts from embryonic day 18 rats to the anterior eye chamber of 16-month-old host animals that were fed either a normal rat chow diet or a 10% hydrogenated coconut oil + 2% cholesterol diet (HFHC diet) for 8 weeks...
2011: Cell Transplantation
V P Veerapur, K R Prabhakar, B S Thippeswamy, Punit Bansal, K K Srinivasan, M K Unnikrishnan
To study the effect and mode of action of water extract (DVW) and polar fraction of ethanol extract (DVE-4) of D. viscosa in high-fructose diet induced insulin resistance in male Wistar rats. D. viscosa's effects were evaluated on a battery of targets involved in glucose homeostasis (in vitro studies). Rats were rendered insulin resistant by feeding 66% (w/w) fructose and 1.1% (v/w) coconut oil mixed with normal pellet diet (NPD) for six weeks. DVW and DVE4 at different doses were administered simultaneously...
August 2010: Indian Journal of Experimental Biology
Benson Mathai Kochikuzhyil, Kshama Devi, Santosh Raghunandan Fattepur
OBJECTIVE: To study the effect of saturated fatty acid (SFA)-rich dietary vegetable oils on the lipid profile, endogenous antioxidant enzymes and glucose tolerance in type 2 diabetic rats. MATERIALS AND METHODS: Type 2 diabetes was induced by administering streptozotocin (90 mg/kg, i.p.) in neonatal rats. Twenty-eight-day-old normal (N) and diabetic (D) male Wistar rats were fed for 45 days with a fat-enriched special diet (10%) prepared with coconut oil (CO) - lauric acid-rich SFA, palm oil (PO) - palmitic acid-rich SFA and groundnut oil (GNO) - control (N and D)...
June 2010: Indian Journal of Pharmacology
Anoop Misra, Neha Singhal, Lokesh Khurana
Developing countries are undergoing rapid nutrition transition concurrent with increases in obesity, the metabolic syndrome, and type 2 diabetes mellitus (T2DM). From a healthy traditional high-fiber, low-fat, low-calorie diet, a shift is occurring toward increasing consumption of calorie-dense foods containing refined carbohydrates, fats, red meats, and low fiber. Data show an increase in the supply of animal fats and increased intake of saturated fatty acid (SFAs) (obtained from coconut oil, palm oil, and ghee [clarified butter]) in many developing countries, particularly in South Asia and South-East Asia...
June 2010: Journal of the American College of Nutrition
B A Houssay, C Martínez
In the experiments described the following observations have been made: (1) The toxic and diabetogenic action of alloxan increases in rats fed a low protein diet and even more so in the case of a high lard or ox fat diet. (2) The action of these fat diets was corrected by the addition of methionine, thiouracil, or coconut oil, but there was no modification either by addition of choline or sulfonamide or by increase in the protein proportion. (3) In rats fed other high fat diets (olive oil, butter) the actions of alloxan were not modified, but there was a slight diminution when high oleomargarine or corn oil diets were fed...
May 23, 1947: Science
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