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Coconut oil AND brain

Débora de Cássia da Silva, Maryane Gabriela Tavares, Camila Karina Brito do Nascimento, Eduardo Carvalho Lira, Ângela Amâncio Dos Santos, Luciana Maria Silva de Seixas Maia, Manuella Batista-de-Oliveira Hornsby
OBJECTIVE: Virgin coconut oil (CO) and treadmill exercise have been reported to improve memory performance in young rats. CO has also been associated with antistress properties in young, stressed mice. Therefore, in this study we aimed to investigate whether CO and treadmill exercise could synergistically ameliorate the effects of chronic stress on anxiety-like behavior and episodic-like memory in young rats. METHODS: The rats received CO and were exercised (Ex) from the 15th to the 45th day of life...
March 1, 2018: Food & Function
Monica Chintapenta, Justin Spence, Hyanggi Irene Kwon, Amie Taggart Blaszczyk
Type 3 diabetes mellitus has been coined to describe an alternative pathologic pathway of Alzheimer's disease (AD). The insulin resistance and impaired insulin signaling seen on positron-emission tomography scans in the brain of those affected by AD support this disease hypothesis. Two products-the medical food caprylidene (Axona) and coconut oil-seek to target the underlying pathology of type 3 diabetes mellitus by providing an alternative fuel source in the brain. Rather than improving glucose utilization, these two products seek to supply ketone bodies in sufficient quantities to pass through the blood-brain barrier and provide an alternative energy source to glucose...
December 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
B C Perng, M Chen, J C Perng, P Jambazian
BACKGROUND: Coconut oil has been widely used to improve health because there is much information available by word of mouth, in books, and on the internet. However, researchers still continue to search for the best diets to improve the quality of life, especially for people with cognitive decline. OBJECTIVES: The aim of this review is to develop a novel dietary approach, the Keto-Mediet, which may help prevent the onset of Alzheimer's disease. METHODS: Evidence gained through literature review from 1982 to 2015 on gene-by-diet interaction and lipid and glucose metabolism in the brains of Alzheimer's patients is converted into the new Keto-Mediet approach...
2017: Journal of Prevention of Alzheimer's Disease
Ching-I Lin, Chu-Fu Shen, Tsui-Han Hsu, Shyh-Hsiang Lin
We investigated the effects of high-fructose-high-fat diets with different fat compositions on metabolic parameters, hippocampal-dependent cognitive function, and brain leptin (as well as stearoyl-CoA desaturase (SCD1) mRNA expressions). Thirty-two male Wistar rats were divided into 3 groups, a control group (n = 8), a high-fructose soybean oil group (37.5% of fat calories, n = 12), and a high-fructose coconut oil group (37.5% of fat calories, n = 12) for 20 weeks. By the end of the study, the coconut oil group exhibited significantly higher serum fasting glucose, fructosamine, insulin, leptin, and triglyceride levels compared to those of the control and soybean oil groups...
June 16, 2017: Nutrients
D Sugasini, B R Lokesh
Docosahexaenoic acid (DHA) is an important long chain omega-3 polyunsaturated fatty acid (PUFA) primarily found in marine fishes. The diets of vegetarian population do not contain preformed DHA, but they can derive it from shorter chain α-linolenic acid (ALA) found in plant oils. However, the conversion efficiency of ALA to DHA is minimal in human adults. This may cause insufficiency of DHA in the vegetarian population. Curcumin, diferuloyl methane found in the spice turmeric, has the potential to increase the formation of DHA from ALA by activating the enzymes FADS2 and elongase 2...
April 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
Nur Syafiqah Rahim, Siong Meng Lim, Vasudevan Mani, Abu Bakar Abdul Majeed, Kalavathy Ramasamy
CONTEXT: Virgin coconut oil (VCO) has been reported to possess antioxidative, anti-inflammatory and anti-stress properties. OBJECTIVE: Capitalizing on these therapeutic effects, this study investigated for the first time the potential of VCO on memory improvement in vivo. MATERIALS AND METHODS: Thirty male Wistar rats (7-8 weeks old) were randomly assigned to five groups (n = six per group). Treatment groups were administered with 1, 5 and 10 g/kg VCO for 31 days by oral gavages...
December 2017: Pharmaceutical Biology
Christopher K Thompson, Hollis T Cline
Thyroid hormone (TH) regulates many cellular events underlying perinatal brain development in vertebrates. Whether and how TH regulates brain development when neural circuits are first forming is less clear. Furthermore, although the molecular mechanisms that impose spatiotemporal constraints on TH action in the brain have been described, the effects of local TH signaling are poorly understood. We determined the effects of manipulating TH signaling on development of the optic tectum in stage 46-49 Xenopus laevis tadpoles...
October 5, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Yudai Nonaka, Tetsuo Takagi, Makoto Inai, Shuhei Nishimura, Shogo Urashima, Kazumitsu Honda, Toshiaki Aoyama, Shin Terada
Coconut oil has recently attracted considerable attention as a potential Alzheimer's disease therapy because it contains large amounts of medium-chain fatty acids (MCFAs) and its consumption is thought to stimulate hepatic ketogenesis, supplying an alternative energy source for brains with impaired glucose metabolism. In this study, we first reevaluated the responses of plasma ketone bodies to oral administration of coconut oil to rats. We found that the coconut oil-induced increase in plasma ketone body concentration was negligible and did not significantly differ from that observed after high-oleic sunflower oil administration...
August 1, 2016: Journal of Oleo Science
Natalia Lausada, Nathalie Arnal, Mariana Astiz, María Cristina Marín, Juan Manuel Lofeudo, Pablo Stringa, María J Tacconi de Alaniz, Nelva Tacconi de Gómez Dumm, Graciela Hurtado de Catalfo, Norma Cristalli de Piñero, María Cristina Pallanza de Stringa, Eva María Illara de Bozzolo, Enrique Gustavo Bozzarello, Diana Olga Cristalli, Carlos Alberto Marra
OBJECTIVE: Brain stroke is the third most important cause of death in developed countries. We studied the effect of different dietary lipids on the outcome of a permanent ischemic stroke rat model. METHODS: Wistar rats were fed diets containing 7% commercial oils (S, soybean; O, olive; C, coconut; G, grape seed) for 35 d. Stroke was induced by permanent middle cerebral artery occlusion. Coronal slices from ischemic brains and sham-operated animals were supravitally stained...
November 2015: Nutrition
Mark F McCarty, James J DiNicolantonio, James H O'Keefe
Ketogenic diets are markedly neuroprotective, but the basis of this effect is still poorly understood. Recent studies demonstrate that ketone bodies increase neuronal levels of hypoxia-inducible factor-1α (HIF-1α), possibly owing to succinate-mediated inhibition of prolyl hydroxylase activity. Moreover, there is reason to suspect that ketones can activate Sirt1 in neurons, in part by increasing cytoplasmic and nuclear levels of Sirt1's obligate cofactor NAD(+). Another recent study has observed reduced activity of mTORC1 in the hippocampus of rats fed a ketogenic diet - an effect plausibly attributable to Sirt1 activation...
November 2015: Medical Hypotheses
Marcela Rodrigues Moreira Guimarães, Leonardo Borges Murad, Aline Paganelli, Carlos Alberto Basílio de Oliveira, Lucia Marques Alves Vianna
Strokes are preceded by oxidative stress and inflammation, two processes linked to atherosclerosis and hypertension. Statins have been widely employed to control atherosclerosis; however, there could be neurological implications to its use—including cognitive impairment. Thus,we aimed to determine whether alpha-tocopherol is capable of reversing the neurological side effects of statins and enhancing its anti-inflammatory properties. To assess these effects, 15-week-old stroke-prone spontaneously hypertensive rats (SHRSPs) were divided into four groups (n = 6, each): alpha-tocopherol (AT), lovastatin (LoV), alpha-tocopherol + lovastatin (AT + LoV), and control (C)...
October 1, 2015: Physiology & Behavior
W M A D B Fernando, Ian J Martins, K G Goozee, Charles S Brennan, V Jayasena, R N Martins
Coconut, Cocos nucifera L., is a tree that is cultivated to provide a large number of products, although it is mainly grown for its nutritional and medicinal values. Coconut oil, derived from the coconut fruit, has been recognised historically as containing high levels of saturated fat; however, closer scrutiny suggests that coconut should be regarded more favourably. Unlike most other dietary fats that are high in long-chain fatty acids, coconut oil comprises medium-chain fatty acids (MCFA). MCFA are unique in that they are easily absorbed and metabolised by the liver, and can be converted to ketones...
July 14, 2015: British Journal of Nutrition
P C De Velasco, P C Sandre, M G Tavares Do Carmo, A C Faria-Melibeu, P Campello-Costa, A C Ferraz, B L S Andrade Da Costa, C A Serfaty
Retinocollicular connections form precise topographical maps that are normally completed through the selective elimination of misplaced axons and the stabilization of topographically ordered axon terminals during early development. Omega-3 fatty acids, acquired exclusively through the diet, and its main metabolite, docosahexaenoic acid (DHA), are involved in brain development and synaptic maturation. We have previously shown that the nutritional restriction of omega-3/DHA results in abnormal retinocollicular topographical fine-tuning...
July 30, 2015: Brain Research
Swee Keong Yeap, Boon Kee Beh, Norlaily Mohd Ali, Hamidah Mohd Yusof, Wan Yong Ho, Soo Peng Koh, Noorjahan Banu Alitheen, Kamariah Long
Virgin coconut oil (VCO) has been consumed worldwide for various health-related reasons and some of its benefits have been scientifically evaluated. Medium-chain fatty acids were found to be a potential antidepressant functional food; however, this effect had not been evaluated in VCO, which is rich in polyphenols and medium-chain fatty acids. The aim of this study was to evaluate the antistress and antioxidant effects of VCO in vivo, using mice with stress-induced injury. The antistress effect of VCO (administered per os, at a dose of 10 ml/kg body weight) was evaluated using the forced swim test and chronic cold restraint stress models...
January 2015: Experimental and Therapeutic Medicine
Tia Maric, Barbara Woodside, Giamal N Luheshi
Recent evidence has demonstrated that consumption of high fat diets can trigger brain inflammation and subsequent injury in the absence of any peripheral inflammatory signaling. Here we sought to investigate whether a link exists between the concentration of highly saturated fats in the diet and the development of inflammation in the brain of rats and, whether the source of the saturated fat was an important factor in this process. Adult male rats had access to diets with a moderate level of total fat (32% of calories as fat) varying in level of saturated fat [low (20%) vs high (>60%)] and its source (butter or coconut oil)...
February 2014: Brain, Behavior, and Immunity
Juliana Kessia Barbosa Soares, Rita de Cássia Ramos do Egypto Queiroga, Marco Aurélio Delmondes Bomfim, Debora Catarine Nepomuceno de Pontes Pessoa, Elida de Andrade Barbosa, Dione Lins Souza, Jose Eulálio Cabral-Filho, Maria do Carmo Medeiros
OBJECTIVE: To investigate the effects of lipids from goat milk containing conjugated linoleic acids on body weight and reflex ontogeny of neonatal rats treated during the prenatal and suckling periods. METHODS: Three groups were studied: soybean oil (S), coconut oil (C), and goat milk lipids (GM). Reflex maturation (palm grasp, righting reflex, cliff avoidance, vibrissae placing, negative geotaxis, auditory startle, and free-fall righting) as well as body weight evolution were recorded during lactation...
January 2014: Nutritional Neuroscience
Patricia Coelho de Velasco, Henrique Rocha Mendonça, Juliana Maria Carrazzone Borba, Belmira Lara da Silveira Andrade da Costa, Rubem Carlos Araujo Guedes, Daniela Maria do Amaral Ferraz Navarro, Geanne Karla Novais Santos, Adriana da Cunha Faria-Melibeu, Paula Campello Costa, Claudio Alberto Serfaty
The development and maturation of sensory systems depends on the correct pattern of connections which occurs during a critical period when axonal elimination and synaptic plasticity are involved in the formation of topographical maps. Among the mechanisms involved in synaptic stabilization, essential fatty acids (EFAs), available only through diet, appear as precursors of signaling molecules involved in modulation of gene expression and neurotransmitter release. Omega-3 fatty acids, such as docosahexaenoic acid (DHA), are considered EFAs and are accumulated in the brain during fetal period and neonatal development...
March 2012: Experimental Neurology
Susan A Farr, Tulin O Price, Ligia J Dominguez, Antonio Motisi, Filippo Saiano, Michael L Niehoff, John E Morley, William A Banks, Nuran Ercal, Mario Barbagallo
Polyphenols are potent antioxidants found in extra virgin olive oil (EVOO); antioxidants have been shown to reverse age- and disease-related learning and memory deficits. We examined the effects of EVOO on learning and memory in SAMP8 mice, an age-related learning/memory impairment model associated with increased amyloid-β protein and brain oxidative damage. We administered EVOO, coconut oil, or butter to 11 month old SAMP8 mice for 6 weeks. Mice were tested in T-maze foot shock avoidance and one-trial novel object recognition with a 24 h delay...
2012: Journal of Alzheimer's Disease: JAD
Linnea R Freeman, Vivian Haley-Zitlin, Cheryl Stevens, Ann-Charlotte Granholm
Consumption of a high-fat and/or high-cholesterol diet can have detrimental effects on the brain. In the present study, dietary treatment with saturated fats, trans fats, or cholesterol to middle-aged Fischer 344 rats resulted in alterations to serum triglyceride and cholesterol levels, organ weights, and hippocampal morphology. Previously, we demonstrated that a 10% hydrogenated coconut oil and 2% cholesterol diet resulted in worse performance on the 12-day water radial arm maze, increased cholesterol and triglyceride levels, and decreased dendritic microtubule associated protein 2 (MAP2) staining in the hippocampus...
January 2011: Nutritional Neuroscience
L R Freeman, B J Small, P C Bickford, C Umphlet, A-Ch Granholm
A diet containing high levels of saturated fat and cholesterol is detrimental to many aspects of health and is known to lead to obesity, metabolic syndrome, heart disease, diabetes, and cancer. However, the effects of a diet rich in saturated fat and cholesterol on the brain are not currently well understood. In order to determine direct effects of a high saturated fat and cholesterol diet upon fetal hippocampal tissue, we transplanted hippocampal grafts from embryonic day 18 rats to the anterior eye chamber of 16-month-old host animals that were fed either a normal rat chow diet or a 10% hydrogenated coconut oil + 2% cholesterol diet (HFHC diet) for 8 weeks...
2011: Cell Transplantation
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