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Coconut oil AND brain

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https://www.readbyqxmd.com/read/27707971/thyroid-hormone-acts-locally-to-increase-neurogenesis-neuronal-differentiation-and-dendritic-arbor-elaboration-in-the-tadpole-visual-system
#1
Christopher K Thompson, Hollis T Cline
: Thyroid hormone (TH) regulates many cellular events underlying perinatal brain development in vertebrates. Whether and how TH regulates brain development when neural circuits are first forming is less clear. Furthermore, although the molecular mechanisms that impose spatiotemporal constraints on TH action in the brain have been described, the effects of local TH signaling are poorly understood. We determined the effects of manipulating TH signaling on development of the optic tectum in stage 46-49 Xenopus laevis tadpoles...
October 5, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27430387/lauric-acid-stimulates-ketone-body-production-in-the-kt-5-astrocyte-cell-line
#2
Yudai Nonaka, Tetsuo Takagi, Makoto Inai, Shuhei Nishimura, Shogo Urashima, Kazumitsu Honda, Toshiaki Aoyama, Shin Terada
Coconut oil has recently attracted considerable attention as a potential Alzheimer's disease therapy because it contains large amounts of medium-chain fatty acids (MCFAs) and its consumption is thought to stimulate hepatic ketogenesis, supplying an alternative energy source for brains with impaired glucose metabolism. In this study, we first reevaluated the responses of plasma ketone bodies to oral administration of coconut oil to rats. We found that the coconut oil-induced increase in plasma ketone body concentration was negligible and did not significantly differ from that observed after high-oleic sunflower oil administration...
August 1, 2016: Journal of Oleo Science
https://www.readbyqxmd.com/read/26429666/dietary-fats-significantly-influence-the-survival-of-penumbral-neurons-in-a-rat-model-of-chronic-ischemic-by-modifying-lipid-mediators-inflammatory-biomarkers-nos-production-and-redox-dependent-apoptotic-signals
#3
Natalia Lausada, Nathalie Arnal, Mariana Astiz, María Cristina Marín, Juan Manuel Lofeudo, Pablo Stringa, María J Tacconi de Alaniz, Nelva Tacconi de Gómez Dumm, Graciela Hurtado de Catalfo, Norma Cristalli de Piñero, María Cristina Pallanza de Stringa, Eva María Illara de Bozzolo, Enrique Gustavo Bozzarello, Diana Olga Cristalli, Carlos Alberto Marra
OBJECTIVE: Brain stroke is the third most important cause of death in developed countries. We studied the effect of different dietary lipids on the outcome of a permanent ischemic stroke rat model. METHODS: Wistar rats were fed diets containing 7% commercial oils (S, soybean; O, olive; C, coconut; G, grape seed) for 35 d. Stroke was induced by permanent middle cerebral artery occlusion. Coronal slices from ischemic brains and sham-operated animals were supravitally stained...
November 2015: Nutrition
https://www.readbyqxmd.com/read/26306884/ketosis-may-promote-brain-macroautophagy-by-activating-sirt1-and-hypoxia-inducible-factor-1
#4
Mark F McCarty, James J DiNicolantonio, James H O'Keefe
Ketogenic diets are markedly neuroprotective, but the basis of this effect is still poorly understood. Recent studies demonstrate that ketone bodies increase neuronal levels of hypoxia-inducible factor-1α (HIF-1α), possibly owing to succinate-mediated inhibition of prolyl hydroxylase activity. Moreover, there is reason to suspect that ketones can activate Sirt1 in neurons, in part by increasing cytoplasmic and nuclear levels of Sirt1's obligate cofactor NAD(+). Another recent study has observed reduced activity of mTORC1 in the hippocampus of rats fed a ketogenic diet - an effect plausibly attributable to Sirt1 activation...
November 2015: Medical Hypotheses
https://www.readbyqxmd.com/read/26095118/effects-of-alpha-tocopherol-associated-with-lovastatin-on-brain-tissue-and-memory-function-in-shrsps
#5
Marcela Rodrigues Moreira Guimarães, Leonardo Borges Murad, Aline Paganelli, Carlos Alberto Basílio de Oliveira, Lucia Marques Alves Vianna
Strokes are preceded by oxidative stress and inflammation, two processes linked to atherosclerosis and hypertension. Statins have been widely employed to control atherosclerosis; however, there could be neurological implications to its use—including cognitive impairment. Thus,we aimed to determine whether alpha-tocopherol is capable of reversing the neurological side effects of statins and enhancing its anti-inflammatory properties. To assess these effects, 15-week-old stroke-prone spontaneously hypertensive rats (SHRSPs) were divided into four groups (n = 6, each): alpha-tocopherol (AT), lovastatin (LoV), alpha-tocopherol + lovastatin (AT + LoV), and control (C)...
October 1, 2015: Physiology & Behavior
https://www.readbyqxmd.com/read/25997382/the-role-of-dietary-coconut-for-the-prevention-and-treatment-of-alzheimer-s-disease-potential-mechanisms-of-action
#6
REVIEW
W M A D B Fernando, Ian J Martins, K G Goozee, Charles S Brennan, V Jayasena, R N Martins
Coconut, Cocos nucifera L., is a tree that is cultivated to provide a large number of products, although it is mainly grown for its nutritional and medicinal values. Coconut oil, derived from the coconut fruit, has been recognised historically as containing high levels of saturated fat; however, closer scrutiny suggests that coconut should be regarded more favourably. Unlike most other dietary fats that are high in long-chain fatty acids, coconut oil comprises medium-chain fatty acids (MCFA). MCFA are unique in that they are easily absorbed and metabolised by the liver, and can be converted to ketones...
July 14, 2015: British Journal of Nutrition
https://www.readbyqxmd.com/read/25916576/a-critical-period-for-omega-3-nutritional-supplementation-in-the-development-of-the-rodent-visual-system
#7
P C De Velasco, P C Sandre, M G Tavares Do Carmo, A C Faria-Melibeu, P Campello-Costa, A C Ferraz, B L S Andrade Da Costa, C A Serfaty
Retinocollicular connections form precise topographical maps that are normally completed through the selective elimination of misplaced axons and the stabilization of topographically ordered axon terminals during early development. Omega-3 fatty acids, acquired exclusively through the diet, and its main metabolite, docosahexaenoic acid (DHA), are involved in brain development and synaptic maturation. We have previously shown that the nutritional restriction of omega-3/DHA results in abnormal retinocollicular topographical fine-tuning...
July 30, 2015: Brain Research
https://www.readbyqxmd.com/read/25452773/antistress-and-antioxidant-effects-of-virgin-coconut-oil-in-vivo
#8
Swee Keong Yeap, Boon Kee Beh, Norlaily Mohd Ali, Hamidah Mohd Yusof, Wan Yong Ho, Soo Peng Koh, Noorjahan Banu Alitheen, Kamariah Long
Virgin coconut oil (VCO) has been consumed worldwide for various health-related reasons and some of its benefits have been scientifically evaluated. Medium-chain fatty acids were found to be a potential antidepressant functional food; however, this effect had not been evaluated in VCO, which is rich in polyphenols and medium-chain fatty acids. The aim of this study was to evaluate the antistress and antioxidant effects of VCO in vivo, using mice with stress-induced injury. The antistress effect of VCO (administered per os, at a dose of 10 ml/kg body weight) was evaluated using the forced swim test and chronic cold restraint stress models...
January 2015: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/24075847/the-effects-of-dietary-saturated-fat-on-basal-hypothalamic-neuroinflammation-in-rats
#9
Tia Maric, Barbara Woodside, Giamal N Luheshi
Recent evidence has demonstrated that consumption of high fat diets can trigger brain inflammation and subsequent injury in the absence of any peripheral inflammatory signaling. Here we sought to investigate whether a link exists between the concentration of highly saturated fats in the diet and the development of inflammation in the brain of rats and, whether the source of the saturated fat was an important factor in this process. Adult male rats had access to diets with a moderate level of total fat (32% of calories as fat) varying in level of saturated fat [low (20%) vs high (>60%)] and its source (butter or coconut oil)...
February 2014: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/23676313/acceleration-of-reflex-maturation-and-physical-development-in-suckling-rats-effects-of-a-maternal-diet-containing-lipids-from-goat-milk
#10
Juliana Kessia Barbosa Soares, Rita de Cássia Ramos do Egypto Queiroga, Marco Aurélio Delmondes Bomfim, Debora Catarine Nepomuceno de Pontes Pessoa, Elida de Andrade Barbosa, Dione Lins Souza, Jose Eulálio Cabral-Filho, Maria do Carmo Medeiros
OBJECTIVE: To investigate the effects of lipids from goat milk containing conjugated linoleic acids on body weight and reflex ontogeny of neonatal rats treated during the prenatal and suckling periods. METHODS: Three groups were studied: soybean oil (S), coconut oil (C), and goat milk lipids (GM). Reflex maturation (palm grasp, righting reflex, cliff avoidance, vibrissae placing, negative geotaxis, auditory startle, and free-fall righting) as well as body weight evolution were recorded during lactation...
January 2014: Nutritional Neuroscience
https://www.readbyqxmd.com/read/22227060/nutritional-restriction-of-omega-3-fatty-acids-alters-topographical-fine-tuning-and-leads-to-a-delay-in-the-critical-period-in-the-rodent-visual-system
#11
Patricia Coelho de Velasco, Henrique Rocha Mendonça, Juliana Maria Carrazzone Borba, Belmira Lara da Silveira Andrade da Costa, Rubem Carlos Araujo Guedes, Daniela Maria do Amaral Ferraz Navarro, Geanne Karla Novais Santos, Adriana da Cunha Faria-Melibeu, Paula Campello Costa, Claudio Alberto Serfaty
The development and maturation of sensory systems depends on the correct pattern of connections which occurs during a critical period when axonal elimination and synaptic plasticity are involved in the formation of topographical maps. Among the mechanisms involved in synaptic stabilization, essential fatty acids (EFAs), available only through diet, appear as precursors of signaling molecules involved in modulation of gene expression and neurotransmitter release. Omega-3 fatty acids, such as docosahexaenoic acid (DHA), are considered EFAs and are accumulated in the brain during fetal period and neonatal development...
March 2012: Experimental Neurology
https://www.readbyqxmd.com/read/21955812/extra-virgin-olive-oil-improves-learning-and-memory-in-samp8-mice
#12
COMPARATIVE STUDY
Susan A Farr, Tulin O Price, Ligia J Dominguez, Antonio Motisi, Filippo Saiano, Michael L Niehoff, John E Morley, William A Banks, Nuran Ercal, Mario Barbagallo
Polyphenols are potent antioxidants found in extra virgin olive oil (EVOO); antioxidants have been shown to reverse age- and disease-related learning and memory deficits. We examined the effects of EVOO on learning and memory in SAMP8 mice, an age-related learning/memory impairment model associated with increased amyloid-β protein and brain oxidative damage. We administered EVOO, coconut oil, or butter to 11 month old SAMP8 mice for 6 weeks. Mice were tested in T-maze foot shock avoidance and one-trial novel object recognition with a 24 h delay...
2012: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/21535919/diet-induced-effects-on-neuronal-and-glial-elements-in-the-middle-aged-rat-hippocampus
#13
Linnea R Freeman, Vivian Haley-Zitlin, Cheryl Stevens, Ann-Charlotte Granholm
Consumption of a high-fat and/or high-cholesterol diet can have detrimental effects on the brain. In the present study, dietary treatment with saturated fats, trans fats, or cholesterol to middle-aged Fischer 344 rats resulted in alterations to serum triglyceride and cholesterol levels, organ weights, and hippocampal morphology. Previously, we demonstrated that a 10% hydrogenated coconut oil and 2% cholesterol diet resulted in worse performance on the 12-day water radial arm maze, increased cholesterol and triglyceride levels, and decreased dendritic microtubule associated protein 2 (MAP2) staining in the hippocampus...
January 2011: Nutritional Neuroscience
https://www.readbyqxmd.com/read/21396159/a-high-fat-high-cholesterol-diet-inhibits-growth-of-fetal-hippocampal-transplants-via-increased-inflammation
#14
L R Freeman, B J Small, P C Bickford, C Umphlet, A-Ch Granholm
A diet containing high levels of saturated fat and cholesterol is detrimental to many aspects of health and is known to lead to obesity, metabolic syndrome, heart disease, diabetes, and cancer. However, the effects of a diet rich in saturated fat and cholesterol on the brain are not currently well understood. In order to determine direct effects of a high saturated fat and cholesterol diet upon fetal hippocampal tissue, we transplanted hippocampal grafts from embryonic day 18 rats to the anterior eye chamber of 16-month-old host animals that were fed either a normal rat chow diet or a 10% hydrogenated coconut oil + 2% cholesterol diet (HFHC diet) for 8 weeks...
2011: Cell Transplantation
https://www.readbyqxmd.com/read/21349251/effect-of-fish-oil-and-coconut-fat-supplementation-on-depressive-type-behavior-and-corticosterone-levels-of-prenatally-stressed-male-rats
#15
COMPARATIVE STUDY
Elizabethe Cristina Borsonelo, Deborah Suchecki, José Carlos Fernandes Galduróz
Prenatal stress (PNS) during critical periods of brain development has been associated with numerous behavioral and/or mood disorders in later life. These outcomes may result from changes in the hypothalamic-pituitary-adrenal (HPA) axis activity, which, in turn, can be modulated by environmental factors, such as nutritional status. In this study, the adult male offspring of dams exposed to restraint stress during the last semester of pregnancy and fed different diets were evaluated for depressive-like behavior in the forced swimming test and for the corticosterone response to the test...
April 18, 2011: Brain Research
https://www.readbyqxmd.com/read/21120792/the-profile-of-fatty-acids-in-frontal-cortex-of-rats-depends-on-the-type-of-fat-used-in-the-diet-and-correlates-with-neuropeptidase-activities
#16
A B Segarra, J I Ruiz-Sanz, M B Ruiz-Larrea, M Ramírez-Sánchez, M de Gasparo, I Banegas, M Martínez-Cañamero, F Vives, I Prieto
The kind of fat in the diet modifies the profile of fatty acids in brain and also affects aminopeptidase activities in tissues. Although modifications in brain fatty acids, neurotransmitters, or enzymes due to dietary fat composition have been reported, no direct relationship has yet been described between specific brain fatty acid changes and neuropeptide metabolism following the fat composition of the diet. We investigated the lipid profile and some neuropeptidase activities in the frontal cortex of adult male rats after a period in which diets were supplemented with fatty acids differing in their degrees of saturation such as fish oil (rich in polyunsaturated fatty acids, PUFAs), olive oil (rich in monounsaturated fatty acids, MUFAs), and coconut oil (rich in saturated fatty acids, SAFAs)...
February 2011: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/20675109/early-development-of-essential-fatty-acid-deficiency-in-rats-fat-free-vs-hydrogenated-coconut-oil-diet
#17
COMPARATIVE STUDY
Pei-Ra Ling, Charlotte E De Leon, Hau Le, Mark Puder, Bruce R Bistrian
This study examined the effects of feeding an essential fatty acid deficient (EFAD) diet either without fat or with added hydrogenated coconut oil (HCO) on fatty acid profiles in rats. Both diets induced equivalent biochemical evidence of EFAD reflected by the triene/tetraene ratio in plasma phospholipids within 2 weeks. However, the HCO diet led to larger increases of 16:1n7 and 18:1n9 in muscle but smaller increases in fat tissue and plasma triglycerides than the fat-free diet, suggesting greater increases in hepatic de novo lipogenesis with the latter...
October 2010: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/20423564/essential-fatty-acid-deficiency-reduces-cortical-spreading-depression-propagation-in-rats-a-two-generation-study
#18
Juliana Maria Carrazzone Borba, Ana Paula Rocha-de-Melo, Angela Amâncio dos Santos, Belmira Lara da Silveira Andrade da Costa, Reginaldo Pereira da Silva, Priscila Pereira Passos, Rubem Carlos Araújo Guedes
Cortical spreading depression (CSD) propagation was investigated in rats under dietary essential fatty acid (EFA) deficiency over two generations (F1 and F2). Wistar rat dams received diets containing 5% fat either from coconut-oil (EFA-deficient) or soybean-oil (control). F1-pups received their dams' diets until the day of CSD recording (30-40 days or 90-100 days). F2-pups were kept on their F1 dams' diet until 30-40 days. Compared to the controls, the EFA-deficient group had reduced (P < 0.05) body weights in both F1 and F2 conditions...
June 2010: Nutritional Neuroscience
https://www.readbyqxmd.com/read/18378130/the-antidepressant-role-of-dietary-long-chain-polyunsaturated-n-3-fatty-acids-in-two-phases-in-the-developing-brain
#19
Anete Curte Ferraz, Agata Kiss, Renata Lins Fuentes Araújo, Hélidy Maria Rossi Salles, Katya Naliwaiko, Juliana Pamplona, Francesca Matheussi
In this work we investigated the effect from fish oil (FO) supplementation, rich in n-3 fatty acids, on an antidepressant effect on adult rats in Phase A (supplementation during pregnancy and lactation) and phase B (supplementation during post-weaning until adulthood). During Phase A, female rats, used as matrix to obtain male rats, were divided in three groups: FO (daily supplemented), CF (coconut fat daily supplemented) and control (not supplemented). Our results showed that adult rats whose mothers were supplemented with FO during Phase A and rats supplemented during phase B demonstrated a significantly decreased immobility time when compared to control and CF groups...
March 2008: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/18028965/inhibition-of-cognitive-decline-in-mice-fed-a-high-salt-and-cholesterol-diet-by-the-angiotensin-receptor-blocker-olmesartan
#20
Masaki Mogi, Kana Tsukuda, Jian-Mei Li, Jun Iwanami, Li-Juan Min, Akiko Sakata, Teppei Fujita, Masaru Iwai, Masatsugu Horiuchi
The metabolic syndrome is closely related to dietary habits and seems to be associated with impairment of cognitive function in humans. Angiotensin receptor blockers are widely used with the expectation of preventing cardiovascular events and stroke and potential amelioration of the metabolic syndrome. We examined the diet-induced changes of cognitive function in mice treated with a high-salt and high-cholesterol diet. C57BL/6J mice were fed a high-salt (2% NaCl in drinking water) and high-cholesterol (1.25% cholesterol, 10% coconut oil) diet (HSCD) or a normal diet (ND), and subjected to 20 trials of a passive avoidance task every week from 8weeks of age...
December 2007: Neuropharmacology
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