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https://www.readbyqxmd.com/read/29228178/genome-sequence-analysis-of-a-hypermucoviscous-hypervirulent-and-mdr-ctx-m-15-k19-st29-klebsiella-pneumoniae-isolated-from-human-infection
#1
Quézia Moura, Fernanda Esposito, Miriam R Fernandes, Maria Espinoza-Muñoz, Tiago A Souza, Silvia R Santos, Louise Cerdeira, Valéria Cassettari, Nilton Lincopan
The emergence of hypervirulent Klebsiella pneumoniae (hvKP) with multidrug-resistance (MDR) profile is a worrisome public health issue. We report the first draft genome sequence of a hypermucoviscous (positive string test) and MDR K. pneumoniae serotype K19, belonging to ST29, isolated from human infection. This strain harboured multiple antimicrobial resistance genes, including blaCTX-M-15, besides yersiniabactin and type 3 fimbriae virulence genes. In vivo experiments carried out with the Galleria mellonella infection model revealed that K...
December 6, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/29217144/histatin-5-induces-the-reversal-of-pdr5p-mediated-fluconazole-resistance-in-saccharomyces%C3%A2-cerevisae
#2
J A da Rocha Curvelo, L F Reis de Sá, D C Clemente de Moraes, R M Soares, A Ferreira-Pereira
BACKGROUND: Candidiasis is a major opportunistic fungal infection in humans. The low number of antifungal drugs available to treat Candida infections and the increasing incidence of multidrug resistant (MDR) strains point to an urgent need of identifying new therapeutic options. The role of salivary components can provide insights for the development of new methodologies of control. OBJECTIVE: The aim of this study was to evaluate the ability of histatin-5, a constitutive immunological peptide present in saliva, in reversing fungal MDR phenotype, using a resistant Saccharomyces cerevisiae strain as model of study...
December 4, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29216350/italian-nationwide-survey-on-pseudomonas-aeruginosa-from-invasive-infections-activity-of-ceftolozane-tazobactam-and-comparators-and-molecular-epidemiology-of-carbapenemase-producers
#3
Tommaso Giani, Fabio Arena, Simona Pollini, Vincenzo Di Pilato, Marco Maria D'Andrea, Lucia Henrici De Angelis, Matteo Bassetti, Gian Maria Rossolini
Objectives: Pseudomonas aeruginosa is a major cause of severe healthcare-associated infections and often shows MDR phenotypes. Ceftolozane/tazobactam is a new cephalosporin/β-lactamase inhibitor combination with potent activity against P. aeruginosa. This survey was carried out to evaluate the susceptibility of P. aeruginosa, circulating in Italy, to ceftolozane/tazobactam and comparators and to investigate the molecular epidemiology of carbapenemase-producing strains. Methods: Consecutive non-replicate P...
December 5, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29213998/phenotypic-and-genetic-characterization-of-%C3%AE-lactam-resistance-in-klebsiella-from-retail-chicken-meat-in-mansoura-egypt
#4
Hazem Ramadan, Amal Awad
Background and Objectives: This study was undertaken to characterize antimicrobial resistance phenotypes and genes encoding extended spectrum β-lactamases (ESBLs) in Klebsiella isolated from retail chicken meat in Mansoura, Egypt. Materials and Methods: Three hundred sixty chicken meat samples from 120 eviscerated chicken carcasses (3 cuts each) collected randomly from local retail chicken shops in Mansoura, Egypt during the period from April to June 2015, were assayed for the presence of Klebsiella by conventional bacteriological methods...
April 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29210348/mediating-effect-of-repeated-tuberculosis-exposure-on-the-risk-of-transmission-to-household-contacts-of-multidrug-resistant-tuberculosis-patients
#5
Peng Lu, Xiaoyan Ding, Qiao Liu, Wei Lu, Leonardo Martinez, Jiansheng Sun, Feng Lu, Chongqiao Zhong, Hui Jiang, Changdong Miao, Limei Zhu, Haitao Yang
Primary Mycobacterium tuberculosis transmission is an important driver of the global epidemic of resistance to tuberculosis drugs. A few studies have compared tuberculosis infection in contacts of index cases with different drug-resistant profiles, suggesting that contacts of multidrug-resistant (MDR) tuberculosis cases are at higher risk. Repeated tuberculosis exposure in contacts of MDR tuberculosis patients through recurrent tuberculosis may modify this relationship. We compared tuberculosis infection in household contacts of MDR and drug-susceptible (DS) tuberculosis patients from six cities in southeastern China and investigated whether repeated tuberculosis exposure was a mediating factor...
December 4, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29210346/serious-neurological-adverse-events-after-ivermectin-do-they-occur-beyond-the-indication-of-onchocerciasis
#6
Rebecca E Chandler
Serious neurological adverse events have been reported from large scale community-based ivermectin treatment campaigns against Onchocerciasis volvulus in Africa. The mechanism of these events has been debated in the literature, largely focusing on the role of concomitant infection with Loa loa versus the presence of mdr-1 gene variants in humans allowing ivermectin penetration into the central nervous system. A case series of serious neurological adverse events occurring with the use of ivermectin outside of the onchocerciasis indication has been identified in VigiBase, an international database of suspected adverse drug reactions...
December 4, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29210342/antibiotics-potentiating-potential-of-catharanthine-against-superbug-pseudomonas-aeruginosa
#7
Gaurav Raj Dwivedi, Rekha Tyagi, Sanchita Gupta, Shubhandra Tripathi, Sanghamitra Pati, Santosh K Srivastava, Mahendra P Darokar, Ashok Sharma
Multidrug resistance (MDR) put an alarming situation like preantibiotic era which compels us to invigorate the basic science of anti-infective chemotherapy. Hence the drug resistant genes/proteins were explored as promising drug targets. Keeping this thing in mind, proteome of Pseudomonas aeruginosa PA01 was explored, which resulted in the identification of tripartite protein complexes (MexA, MexB and OprM) as promising drug target for the screening of natural and synthetic inhibitors. The purpose of present investigation was to explore the drug resistance reversal potential mechanism of catharanthine isolated from the leaves of Catharanthus roseous...
December 6, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29209302/influence-of-stress-and-antibiotic-resistance-on-cell-length-distribution-in-mycobacterium-tuberculosis-clinical-isolates
#8
Srinivasan Vijay, Dao N Vinh, Hoang T Hai, Vu T N Ha, Vu T M Dung, Tran D Dinh, Hoang N Nhung, Trinh T B Tram, Bree B Aldridge, Nguyen T Hanh, Do D A Thu, Nguyen H Phu, Guy E Thwaites, Nguyen T T Thuong
Mycobacterial cellular variations in growth and division increase heterogeneity in cell length, possibly contributing to cell-to-cell variation in host and antibiotic stress tolerance. This may be one of the factors influencing Mycobacterium tuberculosis persistence to antibiotics. Tuberculosis (TB) is a major public health problem in developing countries, antibiotic persistence, and emergence of antibiotic resistance further complicates this problem. We wanted to investigate the factors influencing cell-length distribution in clinical M...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29205192/genetic-diversity-study-of-various-%C3%AE-lactamase-producing-multidrug-resistant-escherichia-coli-isolates-from-a-tertiary-care-hospital-using-eric-pcr
#9
Jayanti Jena, Nagen Kumar Debata, Rajesh Kumar Sahoo, Mahendra Gaur, Enketeswara Subudhi
BACKGROUND & OBJECTIVES: The prevalence of multidrug-resistant (MDR) Escherichia coli isolates producing β-lactamase enzyme is a growing problem across the globe. Strain typing is an epidemiologically important tool not only for detecting the cross transmission of nosocomial pathogens but also for determining the source of infection. The present study was conducted to understand the clonal relationship among various β-lactamase-producing MDR E. coli isolates using enterobacterial repetitive intergenic consensus (ERIC) polymerase chain reaction (PCR)...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29203482/presence-of-mcr-3-variant-in-aeromonas-caviae-proteus-mirabilis-and-escherichia-coli-from-one-domestic-duck
#10
Xiaoming Wang, Weishuai Zhai, Jiyun Li, Dejun Liu, Qidi Zhang, Zhangqi Shen, Shaolin Wang, Yang Wang
The rapid rise and dissemination of MDR bacteria is a major threat to public health worldwide, and has narrowed the treatment options for infections caused by these bacteria (1).….
December 4, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29201114/once-versus-thrice-daily-colistin-in-critically-ill-ptients-with-multi-drug-resistant-infections
#11
Monireh Ghazaeian, Majid Mokhtari, Mehran Kouchek, MirMohammad Miri, Reza Goharani, Robabeh Ghodssi-Ghassemabadi, Mohammad Sistanizad
The aim of this study was to evaluate the procalcitonin (PCT) changes in two different high-dose colistin regimens in the treatment of multi-drug resistant MDR gram negative infections in ICU patients. This is a prospective study of adult ICU patients with bacteremia and ventilator associated pneumonia (VAP) caused by MDR gram negative pathogens. Patients were assigned to two colistin administration groups. Group A received 9 and group B received 3 million international units every 24 and 8 h respectively. Baseline characteristics and measurements of PCT concentrations at the start, the 3rd and the 5th day of the antibiotic therapy and their trends between the two groups were recorded and compared...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29188779/mrsa-prevalence-and-susceptibility-pattern-in-health-care-setups-of-karachi
#12
Tuba Siddiqui, Iyad Naeem Muhammad, Muhammad Naseem Khan, Shazia Naz, Lubna Bashir, Nosheen Sarosh, Rida Masood, Aatka Ali, Sakina Fatima, Talat Naqvi
This assessment aims to determine the prevalence of methicillin resistance and multidrug resistance (MDR) among the clinical isolates of Staphylococcus aureus and antimicrobial susceptibility profile of methicillin resistant Staphylococcus aureus (MRSA) to the frequently prescribed antibiotics in Karachi. Isolates of MRSA, recovered from various clinical samples were included in this prospective, cross-sectional study from Jan 2015 to June 2017. Agar diffusion method was employed according to the protocols of Clinical Laboratory Standards Institute...
November 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29186509/moxifloxacin-target-site-concentrations-in-patients-with-pulmonary-tb-utilizing-microdialysis-a-clinical-pharmacokinetic-study
#13
M Tobias Heinrichs, Sergo Vashakidze, Ketino Nikolaishvili, Irina Sabulua, Nestani Tukvadze, Nino Bablishvili, Shota Gogishvili, Brent P Little, Adam Bernheim, Jeannette Guarner, Charles A Peloquin, Henry M Blumberg, Hartmut Derendorf, Russell R Kempker
Background: Moxifloxacin is a second-line anti-TB drug that is useful in the treatment of drug-resistant TB. However, little is known about its target site pharmacokinetics. Lower drug concentrations at the infection site (i.e. in severe lung lesions including cavitary lesions) may lead to development and amplification of drug resistance. Improved knowledge regarding tissue penetration of anti-TB drugs will help guide drug development and optimize drug dosing. Methods: Patients with culture-confirmed drug-resistant pulmonary TB scheduled to undergo adjunctive surgical lung resection were enrolled in Tbilisi, Georgia...
November 23, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29186432/bacterial-zincophore-s-s-ethylenediamine-n-n-disuccinic-acid-is-an-effective-inhibitor-of-mbls
#14
Anna Proschak, Jan Kramer, Ewgenij Proschak, Thomas A Wichelhaus
Objectives: Carbapenemases such as MBLs are spreading among Gram-negative bacterial pathogens. Infections due to these MDR bacteria constitute a major global health challenge. Therapeutic strategies against carbapenemase-producing bacteria include β-lactamase inhibitor combinations. [S,S]-ethylenediamine-N,N'-disuccinic acid (EDDS) is a chelator and potential inhibitor of MBLs. We investigated the activity of EDDS in combination with imipenem against MBL-producing bacteria in vitro as well as in vivo...
November 23, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29186408/a-significant-therapeutic-effect-of-immunoglobulins-administered-alone-or-in-combination-with-conventional-chemotherapy-in-experimental-pulmonary-tuberculosis-caused-by-drug-sensitive-or-drug-resistant-strains
#15
Nesty Olivares, Yadira Rodriguez, Zyanya Lucia Zatarain-Barron, Brenda Marquina, Dulce Mata-Espinosa, Jorge Barrios-Payán, Cristina Parada, Bárbara Moguel, Clara Espitia Pinzón, Iris Estrada, Rogelio Hernandez-Pando
The recommended chemotherapy for drug sensitive tuberculosis (TB) consists of four different antibiotics administrated for 6-months. This long treatment leads to significant compliance problems and consequently to recrudescence of the disease and to the development of multi drug resistant strains (MDR). Thus, new alternatives are needed to shorten or simplify the treatment of TB. Antibodies have therapeutic effects in animal models of TB, so their use as adjuvants in drug sensitive and MDR TB is an interesting alternative...
November 23, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/29184888/targeting-dna-replication-and-repair-for-the-development-of-novel-therapeutics-against-tuberculosis
#16
REVIEW
Michael A Reiche, Digby F Warner, Valerie Mizrahi
Mycobacterium tuberculosis is the etiological agent of tuberculosis (TB), an infectious disease which results in approximately 10 million incident cases and 1.4 million deaths globally each year, making it the leading cause of mortality from infection. An effective frontline combination chemotherapy exists for TB; however, this regimen requires the administration of four drugs in a 2 month long intensive phase followed by a continuation phase of a further 4 months with two of the original drugs, and is only effective for the treatment of drug-sensitive TB...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29182223/tuberculosis-in-poland-in-2015
#17
Maria Korzeniewska-Koseła
AIM OF THE STUDY: To evaluate the main features of TB epidemiology in 2015 in Poland and to compare with the data on the same phenomena in the EU/EEA countries. METHODS: Analysis of case – based data on TB patients from National TB Register, data on anti-TB drug susceptibility testing results in cases notified in 2015, data from National Institute of Public Health- National Institute of Hygiene on cases of tuberculosis as AIDS-defining disease, data from Central Statistical Office on deaths from tuberculosis based on death certificates, data from ECDC report „ European Centre for Disease Prevention and Control/WHO Regional Office for Europe...
2017: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29181039/epidemiology-and-genetic-diversity-of-colistin-nonsusceptible-nosocomial-acinetobacter-baumannii-strains-from-russia-for-2013-2014
#18
Eugene A Sheck, Mikhail V Edelstein, Marina V Sukhorukova, Natali V Ivanchik, Elena Yu Skleenova, Andrey V Dekhnich, Ilya S Azizov, Roman S Kozlov
A high level of resistance to carbapenems in Acinetobacter baumannii strains severely limits therapeutic possibilities. Colistin is the last resort drug against such strains, although the cases of resistance to this drug have become more frequent. This article presents the epidemiological features and genetic diversity of colistin nonsusceptible A. baumannii strains collected as part of a national multicenter epidemiological study of the antibiotic resistance of pathogens of nosocomial infections (MARATHON), which was conducted in 2013-2014 in Russia...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/29180984/risk-of-transmission-of-antimicrobial-resistant-escherichia-coli-from-commercial-broiler-and-free-range-retail-chicken-in-india
#19
Arif Hussain, Sabiha Shaik, Amit Ranjan, Nishant Nandanwar, Sumeet K Tiwari, Mohammad Majid, Ramani Baddam, Insaf A Qureshi, Torsten Semmler, Lothar H Wieler, Mohammad A Islam, Dipshikha Chakravortty, Niyaz Ahmed
Multidrug-resistant Escherichia coli infections are a growing public health concern. This study analyzed the possibility of contamination of commercial poultry meat (broiler and free-range) with pathogenic and or multi-resistant E. coli in retail chain poultry meat markets in India. We analyzed 168 E. coli isolates from broiler and free-range retail poultry (meat/ceca) sampled over a wide geographical area, for their antimicrobial sensitivity, phylogenetic groupings, virulence determinants, extended-spectrum-β-lactamase (ESBL) genotypes, fingerprinting by Enterobacterial Repetitive Intergenic Consensus (ERIC) PCR and genetic relatedness to human pathogenic E...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29177048/impact-of-single-room-design-on-the-spread-of-multi-drug-resistant-bacteria-in-an-intensive-care-unit
#20
Teysir Halaby, Nashwan Al Naiemi, Bert Beishuizen, Roel Verkooijen, José A Ferreira, Rob Klont, Christina Vandenbroucke-Grauls
Background: Cross-transmission of nosocomial pathogens occurs frequently in intensive care units (ICU). The aim of this study was to investigate whether the introduction of a single room policy resulted in a decrease in transmission of multidrug-resistant (MDR) bacteria in an ICU. Methods: We performed a retrospective study covering two periods: between January 2002 and April 2009 (old-ICU) and between May 2009 and March 2013 (new-ICU, single-room). These periods were compared with respect to the occurrence of representative MDR Gram-negative bacteria...
2017: Antimicrobial Resistance and Infection Control
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