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https://www.readbyqxmd.com/read/28535440/management-of-ventilator-associated-pneumonia-with-a-new-antibiotic-adjuvant-entity-ceftriaxone-sulbactam-disodium-edetate-a-novel-approach-to-spare-carbapenems
#1
Prachee Sathe, Sagar Maddani, Shilpa Kulkarni, Nita Munshi
BACKGROUND: Ventilator associated pneumonia (VAP) is one of the most serious nosocomial infections in Intensive Care Unit (ICU). The aim of this study was to evaluate a new approach to spare the carbapenems for the management of patients diagnosed with VAP due to Acinetobacter baumannii (A. baumannii). METHOD: This retrospective study was conducted on VAP patients presenting for treatment at tertiary care centre between May 2014 and March 2016. The case sheets of patients who have been treated for VAP with meropenem, antibiotic adjuvant entity (AAE) and colistin were analysed...
May 15, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28531351/pharmaceutical-intermediate-modified-gold-nanoparticles-against-multidrug-resistant-bacteria-and-wound-healing-application-via-electrospun-scaffold
#2
Xinglong Yang, Junchuan Yang, Le Wang, Bei Ran, Yuexiao Jia, Lingmin Zhang, Guang Yang, Huawu Shao, Xingyu Jiang
Remedying multidrug-resistant (MDR) bacteria wound infection is major challenge due to the inability of conventional antibiotics in treating such infections against MDR bacteria. Thus, developing wound dressings for wound care, particularly against MDR bacteria, is in huge demand. Here, we present a strategy in designing wound dressings: we use a small molecule (6-aminopenicillanic acid, APA)-coated gold nanoparticles (AuNPs) to inhibit MDR bacteria. We dope the AuNPs into electrospun fibers of poly(ε-caprolactone) (PCL)/gelatin to yield materials that guard against wound infection by MDR bacteria...
May 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28528940/macromolecular-agents-with-antimicrobial-potentialities-a-drive-to-combat-antimicrobial-resistance
#3
REVIEW
Muhammad Bilal, Tahir Rasheed, Hafiz M N Iqbal, Hongbo Hu, Wei Wang, Xuehong Zhang
In recent years, the antimicrobial resistance (AMR) or multidrug resistance (MDR) has become a serious health concern and major challenging issue, worldwide. After decades of negligence, the AMR has now captured global attention. The increasing number of antibiotic-resistant strains has threatened the achievements of science and medicine since it inactivates conventional antimicrobial therapeutics. Scientists are trying to respond to AMR/MDR threat by exploring innovative platforms and new therapeutic strategies to tackle infections from these resistant strains and bypass treatment limitations related to these pathologies...
May 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28526080/post-weaning-diarrhea-in-pigs-risk-factors-and-non-colistin-based-control-strategies
#4
REVIEW
Mohamed Rhouma, John Morris Fairbrother, Francis Beaudry, Ann Letellier
Post-weaning diarrhea (PWD) is one of the most serious threats for the swine industry worldwide. It is commonly associated with the proliferation of enterotoxigenic Escherichia coli in the pig intestine. Colistin, a cationic antibiotic, is widely used in swine for the oral treatment of intestinal infections caused by E. coli, and particularly of PWD. However, despite the effectiveness of this antibiotic in the treatment of PWD, several studies have reported high rates of colistin resistant E. coli in swine...
May 19, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28525941/environmental-contamination-with-staphylococcus-aureus-at-a-large-midwestern-university-campus
#5
Dipendra Thapaliya, Mohammed Taha, Mark R Dalman, Jhalka Kadariya, Tara C Smith
BACKGROUND: Staphylococcus aureus can cause minor to severe life-threatening infections. The changing epidemiology of S. aureus is of public health concern due to the emergence of multi-drug resistant (MDR) strains. Environmental surfaces play a crucial role in the transmission of S. aureus. The objective of this study was to examine environmental contamination and molecular characteristics of S. aureus in health professional-associated (HPA) and non-health professional-associated (NHPA) buildings at a large university...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28523044/evaluation-of-the-synergistic-effect-of-a-combination-of-colistin-and-tigecycline-against-multidrug-resistant-acinetobacterbaumannii
#6
Ilkem Acar Kaya, Muberra Devrim Guner, Gulcin Akca, Semra Tuncbilek, Aslihan Alhan, Emin Tekeli
OBJECTIVE: Acinetobacter baumannii species cause nosocomial infections and can subsequently develop multidrug resistance (MDR). The objective of this study was to evaluate the susceptibility of A. baumannii to a novel combination of colistin and tigecycline, which may provide a faster and more efficacious treatment via a synergistic effect. METHODS: We included 50 MDR A. baumannii samples that were isolated in our clinics between 2009 and 2014. We used broth microdilution (BMD) and the E-test to evaluate the effects of colistin and tigecycline, and the E-test to assess the interaction of the colistin-tigecycline combination...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28522011/vaccination-with-a-live-attenuated-acinetobacter-baumannii-deficient-in-thioredoxin-provides-protection-against-systemic-acinetobacter-infection
#7
Sarah Ainsworth, Patrick M Ketter, Jieh-Juen Yu, Rose C Grimm, Holly C May, Andrew P Cap, James P Chambers, M Neal Guentzel, Bernard P Arulanandam
Multi-drug resistant Acinetobacter baumannii (MDR-Ab), an opportunistic pathogen associated with nosocomial and combat related infections, has a high mortality due to its virulence and limited treatment options. Deletion of the thioredoxin gene (TrxA) from a clinical isolate of MDR-Ab resulted in a 100-fold increase in 50% lethal dose (LD50) in a systemic challenge murine model. Thus, we investigated the potential use of this attenuated strain as a live vaccine against MDR-Ab. Mice were vaccinated by subcutaneous (s...
May 15, 2017: Vaccine
https://www.readbyqxmd.com/read/28521338/klebsiella-pneumoniae-a-major-worldwide-source-and-shuttle-for-antibiotic-resistance
#8
Shiri Navon-Venezia, Kira Kondratyeva, Alessandra Carattoli
Klebsiella pneumoniae is an important multidrug-resistant (MDR) pathogen affecting humans and a major source for hospital infections associated with high morbidity and mortality due to limited treatment options. We summarize the wide resistome of this pathogen, which encompasses plentiful chromosomal and plasmid-encoded antibiotic resistance genes (ARGs). Under antibiotic selective pressure, K. pneumoniae continuously accumulates ARGs, by de novo mutations, and via acquisition of plasmids and transferable genetic elements, leading to extremely drug resistant (XDR) strains harboring a 'super resistome'...
May 1, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28518072/in-vivo-investigation-of-antimicrobial-blue-light-therapy-for-multidrug-resistant-acinetobacter-baumannii-burn-infections-using-bioluminescence-imaging
#9
Yucheng Wang, Olivia D Harrington, Ying Wang, Clinton K Murray, Michael R Hamblin, Tianhong Dai
Burn infections continue to be an important cause of morbidity and mortality. The increasing emergence of multidrug-resistant (MDR) bacteria has led to the frequent failure of traditional antibiotic treatments. Alternative therapeutics are urgently needed to tackle MDR bacteria. An innovative non-antibiotic approach, antimicrobial blue light (aBL), has shown promising effectiveness against MDR infections. The mechanism of action of aBL is not yet well understood. It is commonly hypothesized that naturally occurring endogenous photosensitizing chromophores in bacteria (e...
April 28, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28516494/recommendations-for-approaches-to-meticillin-resistant-staphylococcal-infections-of-small-animals-diagnosis-therapeutic-considerations-and-preventative-measures-clinical-consensus-guidelines-of-the-world-association-for-veterinary-dermatology
#10
REVIEW
Daniel O Morris, Anette Loeffler, Meghan F Davis, Luca Guardabassi, J Scott Weese
BACKGROUND: Multiple drug resistance (MDR) in staphylococci, including resistance to the semi-synthetic penicillinase-resistant penicillins such as meticillin, is a problem of global proportions that presents serious challenges to the successful treatment of staphylococcal infections of companion animals. OBJECTIVES: The objective of this document is to provide harmonized recommendations for the diagnosis, prevention and treatment of meticillin-resistant staphylococcal infections in dogs and cats...
June 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28513421/clinical-and-bacteriological-characteristics-associated-with-clustering-of-multidrug-resistant-tuberculosis
#11
J-Y J-Y Feng, L G Jarlsberg, K Salcedo, J Rose, M Janes, S-Y G Lin, D H Osmond, K C Jost, M K Soehnlen, J Flood, E A Graviss, E Desmond, P K Moonan, P Nahid, P C Hopewell, M Kato-Maeda
<h2>SETTING:</h2><p>The impact of the genetic characteristics of Mycobacterium tuberculosis on the clustering of multidrug-resistant tuberculosis (MDR-TB) has not been analyzed together with clinical and demographic characteristics.</p><h2>OBJECTIVE:</h2><p>To determine factors associated with genotypic clustering of MDR-TB in a community-basedstudy.</p><h2>DESIGN:</h2><p>We measured the proportion of clustered cases among MDR-TB patients and determined the impact of clinical and demographic characteristics and that of three M...
May 16, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28512603/bactericidal-activity-of-herbal-volatile-oil-extracts-against-multidrug-resistant-acinetobacter-baumannii
#12
Amornrat Intorasoot, Piyaorn Chornchoem, Siriwoot Sookkhee, Sorasak Intorasoot
AIM: The aim of the study is to investigate the antibacterial activity of 10 volatile oils extracted from medicinal plants, including galangal (Alpinia galanga Linn.), ginger (Zingiber officinale), plai (Zingiber cassumunar Roxb.), lime (Citrus aurantifolia), kaffir lime (Citrus hystrix DC.), sweet basil (Ocimum basilicum Linn.), tree basil (Ocimum gratissimum), lemongrass (Cymbopogon citratus DC.), clove (Syzygium aromaticum), and cinnamon (Cinnamomum verum) against four standard strains of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, and 30 clinical isolates of multidrug-resistant A...
April 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28511708/enzyme-mediated-formulation-of-stable-elliptical-silver-nanoparticles-tested-against-clinical-pathogens-and-mdr-bacteria-and-development-of-antimicrobial-surgical-thread
#13
Rupak Thapa, Chintan Bhagat, Pragya Shrestha, Suvash Awal, Pravin Dudhagara
BACKGROUND: Silver nanoparticles (AgNPs) are believed to be emerging tool against various infectious diseases including multi-drug resistant (MDR) bacteria. In the present study, in vitro synthesis of AgNPs was optimized using 1:50 ratio of macerozyme (25 μg/μl) and 1 mM AgNO3 incubated at 80 °C for 8 h. AgNPs were characterized by UV-Visible spectroscopy, dynamic light scattering (DLS), scanning electron microscopy, energy-dispersive X-ray spectroscopy, transmission electron microscopy (TEM) and X-ray diffraction (XRD)...
May 16, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28507348/microbiological-pattern-of-diabetic-foot-infections-at-a-tertiary-care-center-in-a-developing-country
#14
Zahid Miyan, Asher Fawwad, Rubina Sabir, Abdul Basit
OBJECTIVE: To determine the microbiological profile and antibiotic susceptibility patterns of organisms isolated from diabetic foot ulcers in a tertiary care hospital Karachi, Pakistan. METHODS: This descriptive study was conducted at the Baqai Institute of Diabetology and Endocrinology (BIDE), from January 2013 to March 2014. Bone, pus and tissue samples were collected from 342 patients with diabetic foot infections and inoculated on appropriate media. Antibiotic susceptibility tests were done by Kirby Bauer disk diffusion method...
May 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28506250/antimicrobial-resistance-profile-of-staphylococcus-aureus-isolates-isolated-from-ear-discharges-of-patients-at-university-of-hawassa-comprehensive-specialized-hospital
#15
Serawit Deyno, Alemayehu Toma, Mesfin Worku, Muluken Bekele
BACKGROUND: Drug-resistant microorganism are a growing global danger. Strains of S. aureus have developed resistance to many commonly used antimicrobials due to indiscriminate use of antimicrobials, and treatment becoming a challenge. Studies assessing pattern and determinants of S. aureus resistance in ear infection in Ethiopia are very scarce. This study presents overview of pattern and determinants S. aureus resistance from samples of ear discharge in Ethiopia. METHOD: A prospective cross-sectional study was conducted on patients who visit ENT clinic of University of Hawassa comprehensive specialized hospital from February 1, 2016 to November 1, 2016...
May 15, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28505331/antimicrobial-susceptibility-of-clinical-isolates-of-neisseria-gonorrhoeae-to-alternative-antimicrobials-with-therapeutic-potential
#16
P R S Lagacé-Wiens, H J Adam, N M Laing, M R Baxter, I Martin, M R Mulvey, J A Karlowsky, D J Hoban, G G Zhanel
Background: The prevalence of MDR Neisseria gonorrhoeae is increasing globally and represents a public health emergency. Development and approval of new anti-gonococcal agents may take years. As a concurrent approach to developing new antimicrobials, the laboratory and clinical evaluation of currently licensed antimicrobials not widely used for the treatment of gonorrhoea may provide new options for the treatment of gonococcal infections. Objectives: To determine the in vitro activity of nine alternative, currently licensed and late-development antimicrobials with the potential to treat gonococcal infections against 112 clinical isolates of N...
May 12, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28503342/phenotypic-detection-and-antibiogram-of-%C3%AE-lactamase-producing-proteus-species-in-a-tertiary-care-hospital-india
#17
N Pal, S Hooja, R Sharma, R K Maheshwari
BACKGROUND: Proteus species cause a variety of community- and hospital-acquired illnesses. Synthesis of β-lactamases is the predominant mechanism for resistance to β-lactam antibiotics. Among the β-lactamases, extended spectrum β-lactamases (ESBLs) and AmpC β-lactamases are the most common. AIM: The objective of this study was to determine the occurrence of ESBL and AmpC β-lactamases in Proteus species among various clinical isolates at a tertiary care hospital, India...
September 2016: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/28503325/ceftolozane-tazobactam-for-febrile-uti-due-to-multidrug-resistant-pseudomonas-aeruginosa-in-a-patient-with-neurogenic-bladder
#18
Aurélien Dinh, Benjamin Davido, Ruxandra Calin, Julie Paquereau, Clara Duran, Frédérique Bouchand, Véronique Phé, Emmanuel Chartier-Kastler, Martin Rottman, Jérôme Salomon, Patrick Plésiat, Anaïs Potron
INTRODUCTION: Urinary tract infections (UTI) are a major public health problem among spinal cord injury (SCI) patients. They frequently involve multidrug-resistant (MDR) bacteria. Ceftolozane/tazobactam (C/T) is a novel antibiotic combination approved for complicated intra-abdominal and UTI caused by Gram-positive and Gram-negative organisms, including some MDR strains. Little is known about the use of this agent for complicated febrile UTI occurring among SCI patients with neurogenic bladder due to MDR Pseudomonas aeruginosa (PSA)...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28500792/changing-trends-in-the-aetiology-treatment-and-outcomes-of-bloodstream-infection-occurring-in-the-first-year-after-solid-organ-transplantation-a-single-centre-prospective-cohort-study
#19
Isabel Oriol, Núria Sabé, Antonella F Simonetti, Laura Lladó, Anna Manonelles, Jose González, Fe Tubau, Jordi Carratalà
To analyse trends in the aetiology, treatment and outcomes of BSI within the first year post-transplant over the last 10-year period, we prospectively recorded all episodes of BSI occurring in SOT recipients during the first year post-transplant from 2007 to 2016. Trends of factors were analysed by 2-year periods. Of 475 consecutive episodes of BSI, 218 occurred within a year of SOT in 178 SOT recipients. Gram-positive BSI decreased over time (40.5% to 2.2%). In contrast, there was a steady increase in Gram-negative bacilli (GNB) BSI (54...
May 13, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28497114/selectable-markers-for-use-in-genetic-manipulation-of-extensively-drug-resistant-xdr-acinetobacter-baumannii-humc1
#20
Brian M Luna, Amber Ulhaq, Jun Yan, Paul Pantapalangkoor, Travis B Nielsen, Bryan W Davies, Luis A Actis, Brad Spellberg
Acinetobacter baumannii is one of the most antibiotic-resistant pathogens in clinical medicine, and extensively drug-resistant (XDR) strains are commonly isolated from infected patients. Such XDR strains are already resistant to traditional selectable genetic markers, limiting the ability to conduct pathogenesis research by genetic disruption. Optimization of selectable markers is therefore critical for the advancement of fundamental molecular biology techniques to use in these strains. We screened 23 drugs that constitute a broad array of antibiotics spanning multiple drug classes against HUMC1, a highly virulent and XDR A...
March 2017: MSphere
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