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Achilles tendinitis

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https://www.readbyqxmd.com/read/28806294/the-tissue-engineered-tendon-bone-interface-in-vitro-and-in-vivo-synergistic-effects-of-adipo-derived-stem-cells-platelet-rich-plasma-and-extracellular-matrix-hydrogel
#1
Rory McGoldrick, Arhana Chattopadhyay, Christopher Crowe, Grace Chiou, Kenneth Hui, Simon Farnebo, Christopher Davis, Anais Le Grand, Molly Jacobs, Hung Pham, James Chang
INTRODUCTION: Suboptimal healing of the tendon bone interface (TBI) remains an unsolved problem. One solution is a biocompatible tissue engineered construct that promotes augmented healing. We hypothesisze that 1.) the presence of Platelet Rich Plasma (PRP) and prolonged in vitro incubation produces tissue engineered tendon bone interface scaffolds with greater reseeding of viable Adipo-derived Stem Cells (ADSC) and 2.) when implanted with extracellular matrix hydrogel, constructs will display superior in vivo strength repair and biocompatibility...
August 3, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28766166/rhpdgf-bb-combined-with-adscs-in-the-treatment-of-achilles-tendinitis-via-mir-363-pi3%C3%A2-k-akt-pathway
#2
Qiao-Jie Chen, Liang Chen, Shao-Kun Wu, Yao-Jun Wu, Qing-Jiang Pang
To investigate the mechanism of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and human adipose-derived stem cells (hADSCs) in the treatment of Achilles tendinitis. Biomechanical indices of stiffness, stress, and maximum load-to-failure were detected by biomechanical test. mRNA and protein levels of miR-363, p-PI3K/AKT, tendon-related genes Collagen I, Scleraxis (Scx), and Tenascin C (TNC) were measured by qRT-PCR and western blot. The proliferation of hADSCs was accessed by MTT assay. Biomechanical indices of stiffness, stress, and maximum load-to-failure, and mRNA and protein levels of tendon-related genes could be improved by rhPDGF-BB or hADSCs alone, and could be further improved by rhPDGF-BB + hADSCs...
August 1, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28728791/the-effects-of-achilles-tendon-compliance-on-triceps-surae-mechanics-and-energetics-in-walking
#3
Maria Isabel V Orselli, Jason R Franz, Darryl G Thelen
Achilles tendon (AT) compliance can affect the generation and transmission of triceps surae muscle forces, and thus has important biomechanical consequences for walking performance. However, the uniarticular soleus (SOL) and the biarticular (GAS) function differently during walking, with in vivo evidence suggesting that their associated fascicles and tendinous structures exhibit unique kinematics during walking. Given the strong association between muscle fiber length, velocity and force production, we conjectured that SOL and GAS mechanics and energetic behavior would respond differently to altered AT compliance...
July 26, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28717615/outcomes-of-prolotherapy-for-intra-tendinous-achilles-tears-a-case-series
#4
Otto Chan, Ben Havard, Sarah Morton, Mel Pritchard, Nicola Maffulli, Tom Crisp, Nat Padhiar, Jeremy David Perry, John King, Dylan Morrissey
BACKGROUND: The intra-tendinous tear is a new pathology that is defined as a discontinuity of fibres situated entirely within the tendon. Prolotherapy involves injecting an irritant, such as hyperosmolar dextrose, to stimulate a tissue healing response and ultimately reduce pain. METHODS: 43 consecutive patients diagnosed with an intra-tendinous tear were included (27 males: 16 females, mean (SD) age 41 (11.3). Patients were injected with 0.4ml-1.5ml (mean 0.8ml) of 50% dextrose and 0...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28587393/effects-of-hypoxia-on-differentiation-of-menstrual-blood-stromal-stem-cells-towards-tenogenic-cells-in-a-co-culture-system-with-achilles-tendon-cells
#5
Yijing Zheng, Yifei Zhou, Xiaolei Zhang, Yuemiao Chen, Xuhao Zheng, Tao Cheng, Chaonan Wang, Xuqi Hu, Jianjun Hong
Achilles tendons have a very poor capacity for intrinsic regeneration. The cell-based treatment strategy for Achilles tendinitis includes the application of mesenchymal stem cells (MSCs), which have high proliferative and multipotent differentiation ability, and is a promising approach. The aim of the present study was to explore the tenogenic potential of human menstrual blood stromal stem cells (MenSCs) in a co-culture system and to compare the tenogenic capability under normoxic and hypoxic conditions. MenSCs were co-cultured indirectly with Achilles tendon cells in a Transwell co-culture system for 1, 2, or 3 weeks in two different concentrations of oxygen (20 and 2% O2), whereas the control contained only MenSCs...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28446388/medial-shoe-ground-pressure-and-specific-running-injuries-a-1-year-prospective-cohort-study
#6
René B K Brund, Sten Rasmussen, Rasmus O Nielsen, Uwe G Kersting, Uffe Laessoe, Michael Voigt
OBJECTIVES: Achilles tendinitis, plantar fasciopathy and medial tibial stress syndrome injuries (APM-injuries) account for approximately 25% of the total number of running injuries amongst recreational runners. Reports on the association between static foot pronation and APM-injuries are contradictory. Possibly, dynamic measures of pronation may display a stronger relationship with the risk of APM-injuries. Therefore, the purpose of the present study was to investigate if running distance until the first APM-injury was dependent on the foot balance during stance phase in recreational male runners...
April 15, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28410782/posterior-arthroscopic-tibiotalar-arthrodesis-anatomic-feasibility-study
#7
Louis Malekpour, Said Rahali, Damien Potage, Fabrice Duparc, Franck Dujardin, Xavier Roussignol
Anterior arthroscopic tibiotalar arthrodesis has been well codified. A posterior approach with the patient in prone position is indicated when the anterior approach is precluded by soft tissue issues or for a 1-step procedure associated with posterior subtalar fusion. In an anatomic study, we assessed the feasibility of posterior arthroscopic tibiotalar fusion and sought to determine the arthroscopy entry points, mortise cartilage freshening quality, and risk of osseous, tendinous, vascular, and neural complications...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28394684/treatment-algorithm-for-chronic-achilles-tendon-lesionsreview-of-the-literature-and-proposal-of-a-new-classification
#8
Roberto Buda, Francesco Castagnini, Gherardo Pagliazzi, Sandro Giannini
Chronic Achilles tendon lesions (CATLs) ensue from a neglected acute rupture or a degenerated tendon. Surgical treatment is usually required. The current English literature (PubMed) about CATLs was revised, and particular emphasis was given to articles depicting CATL classification. The available treatment algorithms are based on defect size. We propose the inclusion of other parameters, such as tendon degeneration, etiology, and time from injury to surgery. Partial lesions affecting less than (I stage) or more than (II stage) half of the tendon should be treated conservatively for healthy tendons, within 12 weeks of injury...
March 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28321341/singleton-merten-syndrome-a-rare-cause-of-early-onset-aortic-stenosis
#9
Harshavardhan Ghadiam, Sudhir Mungee
Singleton Merten syndrome (SMS) is a rare autosomal dominant genetic disorder with variable expression. Its characteristic features include abnormal aortic calcification, abnormal ossification of extremities, and dental anomalies. We present a young man with dyspnea who was noted to have aortic stenosis in the background of glaucoma, psoriasis, dental anomalies, hand and foot deformities, Achilles tendinitis, osteopenia, and nephrolithiasis. The conglomeration of features led to the diagnosis of SMS. His mother had a very similar phenotype...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28294565/ankle-pathologies-in-patients-with-inflammatory-rheumatic-diseases-a-clinical-and-ultrasonographic-study
#10
Halil Harman, İbrahim Tekeoğlu
AIM: We determined ankle pathologies in patients with different types of inflammatory rheumatic diseases using high-resolution ultrasonographic (US) images, and compared the findings among the different patient groups. METHODS: The study included 142 randomly selected inflammatory rheumatic disease patients with clinically swollen or painful ankle joints; 69 patients had rheumatoid arthritis (RA), 58 had spondyloarthropathies (SpA) and 15 had gout. Ankle assessment on US included all of the important anatomical structures...
March 12, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28257670/noninsertional-achilles-tendinopathy-pathologic-background-and-clinical-examination
#11
REVIEW
Mindi Feilmeier
The term tendinopathy includes a series of pathologies, all of which have a combination of pain, swelling, and impaired performance. The terms tendinosis, tendinitis and peritendinitis are all within the main heading of tendinopathy; this terminology provides a more accurate understanding of the condition and highlights the uniformity of clinical findings while distinguishing the individual histopathological findings of each condition. Understanding the clinical features and the underlying histopathology leads to a more accurate clinical diagnosis and subsequent treatment selection...
April 2017: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/28139009/the-twisted-structure-of-the-achilles-tendon-unraveled-a-detailed-quantitative-and-qualitative-anatomical-investigation
#12
P A Pękala, B M Henry, A Ochała, P Kopacz, G Tatoń, A Młyniec, J A Walocha, K A Tomaszewski
The Achilles tendon (AT) consists of fibers originating from the soleus muscle (SOL), which lies deep, and the medial (GM) and lateral (GL) heads of the gastrocnemius muscle, which lie superficial. As the fibers descend toward the insertion of the AT, the individual subtendons twist around each other. The aim of this study was to investigate the twisted structure of the AT and its individual subtendons. Specimens of the AT, with preserved calcaneal bone and a fragment of the triceps surae muscle, were obtained from 53 fresh-frozen, male cadavers (n=106 lower limbs)...
January 30, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28027872/the-effect-of-platelet-rich-plasma-on-achilles-tendon-healing-in-a-rabbit-model
#13
Masaki Takamura, Toshito Yasuda, Atsushi Nakano, Hiroaki Shima, Masashi Neo
OBJECTIVE: The aim of the present study was to evaluate the effects of PRP on Achilles tendon healing in rabbits during the inflammatory, proliferative, and remodeling phases by histological examination and quantitative assessments. METHODS: Fifty mature male Japanese albino rabbits with severed Achilles tendons were divided into two equal groups and treated with platelet-rich plasma (PRP) or left untreated. Tendon tissue was harvested at 1, 2, 3, 4, and 6 weeks after treatment, and sections were stained with hematoxylin-eosin and monoclonal antibodies against CD31 and type I collagen...
January 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27833002/a-mathematical-model-characterising-achilles-tendon-dynamics-in-flexion
#14
N Chatzistefani, M J Chappell, C Hutchinson, S Kletzenbauer, N D Evans
The purpose of this study is to acquire mechanistic knowledge of the gastrocnemius muscle-Achilles tendon complex behaviour during specific movements in humans through mathematical modelling. Analysis of this muscle-tendon complex was performed to see if already existing muscle-tendon models of other parts of the body could be applied to the leg muscles, especially the gastrocnemius muscle-Achilles tendon complex, and whether they could adequately characterise its behaviour. Five healthy volunteers were asked to take part in experiments where dorsiflexion and plantar flexion of the foot were studied...
November 8, 2016: Mathematical Biosciences
https://www.readbyqxmd.com/read/27746496/reconstruction-of-kuwada-grade-iv-chronic-achilles-tendon-rupture-by-minimally-invasive-technique
#15
Xudong Miao, Yongping Wu, Huimin Tao, Disheng Yang, Lu Huang
BACKGROUND: Transfer of a flexor hallucis longus (FHL) tendon can not only reconstruct the Achilles tendon but also provide ischemic tendinous tissues with a rich blood supply to enhance wound healing. This retrospective study aims to investigate clinical outcomes in patients who underwent repair of Kuwada grade IV chronic Achilles tendon rupture with long hallucis longus tendons harvested using a minimally invasive technique. MATERIALS AND METHODS: 35 patients who were treated for Kuwada grade IV Achilles tendon injuries from July 2006 to June 2011 were included in this retrospective study...
September 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27671520/the-effect-of-foot-overpronation-on-achilles-tendon-blood-supply-in-healthy-male-subjects
#16
K Karzis, M Kalogeris, D Mandalidis, N Geladas, K Karteroliotis, S Athanasopoulos
The purpose of this study was to investigate Achilles tendon blood flow in individuals with overpronated feet during non-weight- and weight-bearing positions. Achilles tendon blood flow was measured by means of the pulsatility index (PI) and the resistance index (RI) in 15 male individuals with overpronated feet and 15 counterparts with normal feet, using power Doppler ultrasonography (PDI). Achilles tendon ultrasonographic (US) assessment was performed at its musculo-tendinous junction (MTJ), mid-tendon (MT), and osseotendinous junction (OTJ) at a non-weight-bearing relaxed position (RP) and during two-leg stance (TLS) and one-leg upright stance (OLS)...
September 27, 2016: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/27578138/an-unusual-cause-of-achilles-tendon-xanthoma
#17
Fabienne Parente, Matthew Vesnaver, Rami Massie, Alexis Baass
Tendinous xanthomas are often thought to be pathognomonic for familial hypercholesterolemia. In this report, we present the case of a young man with a normal lipid profile and Achilles tendon xanthoma. Biochemical and genetic studies confirmed the diagnosis of cerebrotendinous xanthomatosis in this patient. Cerebrotendinous xanthomatosis is a rare autosomal recessive disease associated with xanthoma in tendons and the brain as well as progressive neurologic deficits. Unfortunately, this rare form of reversible dementia is thought to be underdiagnosed...
July 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27517731/genome-wide-analysis-identifies-differential-promoter-methylation-of-leprel2-foxf1-mmp25-igfbp6-and-peg12-in-murine-tendinopathy
#18
Katie J Trella, Jun Li, Eleni Stylianou, Vincent M Wang, Jonathan M Frank, Jorge Galante, John D Sandy, Anna Plaas, Robert Wysocki
We have used a murine Achilles tendinopathy model to investigate whether tissue changes (such as collagen disorganization, chondroid metaplasia, and loss of tensile properties) which are broadly characteristic of human tendinopathies, are accompanied by changes in the expression of chromatin-modifying enzymes and the methylation status of promoter regions of tendon cell DNA. Tendinopathy was induced by two intra-tendinous TGF-β1 injections followed by cage activity or treadmill running for up to 28 days. Activation of DNA methyltransferases occurred at 3 days after the TGF-β1 injections and also at 14 days, but only with treadmill activity...
May 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27477928/what-tendon-pathology-is-seen-on-imaging-in-people-who-have-taken-fluoroquinolones-a-systematic-review
#19
REVIEW
Tina R Lang, Jill Cook, Ebonie Rio, James E Gaida
Fluoroquinolones (FQs) are highly effective broad-spectrum antibiotics. Clinical data reveal an increased incidence of tendon pain and rupture in those taking FQs, yet little is known about tendon structural changes. This review synthesises published data on tendon structural changes in people who have taken FQs. Eight databases were searched for potentially relevant articles (Medline, CINAHL, Biological Abstracts, AMED, Web of Knowledge, SCOPUS, SportDiscus and EMBASE) using MeSH and free-text searches. Inclusion and exclusion criteria determined which articles were used for this review...
February 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/27470952/-comparative-analysis-of-the-ankle-joints-in-juvenile-male-soccer-players-with-imaging
#20
COMPARATIVE STUDY
Y B Huang, Y X Zhao, J J Xiao, M W Li, R Zhang, S L Li
OBJECTIVE: To investigate the characteristics of children male soccer players' ankle imaging features. METHODS: From October 2015 to February 2016, a total of 32 male children players of two soccer clubs in Guangzhou were enrolled in this study.The ages of all cases were from 10 to 14 years, average age was (11.3±0.9) years.A total of 15 male children in region ordinary primary and secondary school students were set as control group, ages were from 10 to 14 years, average age was (12...
July 5, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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