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Chondrocalcinosis

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https://www.readbyqxmd.com/read/27933211/systematic-review-and-quality-analysis-of-emerging-diagnostic-measures-for-calcium-pyrophosphate-crystal-deposition-disease
#1
Y Wu, K Chen, R Terkeltaub
OBJECTIVES: Calcium pyrophosphate crystal deposition disease (CPPD) is common, yet prevalence and overall clinical impact remain unclear. Sensitivity and specificity of CPPD reference standards (conventional crystal analysis (CCA) and radiography (CR)) were meta-analysed by EULAR (published 2011). Since then, new diagnostic modalities are emerging. Hence, we updated 2009-2016 literature findings by systematic review and evidence grading, and assessed unmet needs. METHODS: We performed systematic search of full papers (PubMed, Scopus/EMBASE, Cochrane 2009-2016 databases)...
2016: RMD Open
https://www.readbyqxmd.com/read/27917633/-differential-diagnosis-of-monoarthritis
#2
Kateřina Zegzulková, Šárka Forejtová
Making the diagnosis of monoarthritis can be quite difficult, because in contrast with polyarthritis just a few clinical data is available and wide diagnostic spectrum is present.The diagnosis of inflammatory rheumatic disease is usually in responsibility of a rheumatologist, but we know from experience that is necessary to carry out the basal differential diagnostic assessment as soon as possible to begin the optimal therapy. General practitioners and orthopaedists are usually first to face this problem.Monoarthritis can be divided into non-inflammatory arthritis where activated osteoarthritis and trauma belongs and inflammatory arthritis, which include gouty arthritis, chondrocalcinosis, infectious arthritis, juvenile idiopathic arthritis, spondylitis, incipient rheumatoid arthritis and many others...
2016: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/27890247/reproducibility-of-x-rays-and-ct-arthrography-in-slac-snac-scac-wrists
#3
R Belhaouane, N Lebeau, C Maes-Clavier, C Hustin, E Krief, B Bonnaire, M Warin, V Rotari, E David
The purpose of this study was to assess the inter-observer and intra-observer reproducibility of the interpretation of CT arthrography and plain X-rays for scapholunate advanced collapse (SLAC), scaphoid non-union advanced collapse (SNAC) and scaphoid chondrocalcinosis advanced collapse (SCAC) wrist conditions, as well as the clinical relevance of these imaging modalities. The CT and X-rays images were reviewed twice in a blinded and randomized manner by two experienced orthopedic surgeons specialized in hand surgery, two orthopedic surgery residents and two experienced radiologists specialized in bone and joint imaging...
December 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27848164/septic-arthritis-due-to-legionella-cincinnatiensis-case-report-and-review-of-the-literature
#4
Florian Banderet, Annette Blaich, Evelin Soleman, Valeria Gaia, Michael Osthoff
Legionella spp. are an important cause of pulmonary and rarely extrapulmonary infections. L. cincinnatiensis has only been implicated in five cases to date. We herein report the first case of L. cincinnatiensis septic arthritis in a 90-year old lady with a past medical history of chronic kidney disease. She developed septic arthritis of her left wrist after having received intraarticular corticosteroid injections and oral corticosteroids administered for presumed chondrocalcinosis. Appropriate antimicrobial treatment of L...
November 15, 2016: Infection
https://www.readbyqxmd.com/read/27815654/musculoskeletal-manifestations-of-primary-hyperparathyroidism
#5
REVIEW
Ramesh Pappu, Serge A Jabbour, Antonio M Regianto, Antonio J Reginato
Primary hyperparathyroidism (PHPT) can be associated with a variety of musculoskeletal complaints, which occasionally can be the leading or presenting manifestation. In this paper, we describe the musculoskeletal manifestations observed in patients with primary hyperparathyroidism. Medical record reviews of a select population of 74 patients with primary hyperparathyroidism are seen in a rheumatology practice. Bone manifestations included back pain in 11 patients (15.2 %), generalized bone pain in 7 patients (9...
November 4, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27777815/the-prevalence-of-pisotriquetral-arthritis-in-the-setting-of-scapholunate-advanced-collapse
#6
Schneider K Rancy, Samir K Trehan, Angela E Li, Steve K Lee, Hollis G Potter, Scott W Wolfe
Background Previous authors have reported pisotriquetral pain and subsequent pisiform excision following partial or total wrist fusion in patients with scapholunate advanced collapse (SLAC). Prior studies have not considered the potential role of SLAC biomechanics on pisotriquetral osteoarthritis (PT OA) development preoperatively. Purpose To determine the prevalence and severity of PT OA in patients with SLAC as compared with a control population. Patients and Methods Magnetic resonance imaging (MRI) studies of 24 patients with SLAC wrist and 24 sex- and age-matched control patients were analyzed...
November 2016: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/27704199/evaluation-of-chondrocalcinosis-and-associated-knee-joint-degeneration-using-mr-imaging-data-from-the-osteoarthritis-initiative
#7
Alexandra S Gersing, Benedikt J Schwaiger, Ursula Heilmeier, Gabby B Joseph, Luca Facchetti, Martin Kretzschmar, John A Lynch, Charles E McCulloch, Michael C Nevitt, Lynne S Steinbach, Thomas M Link
OBJECTIVES: To evaluate the ability of different MRI sequences to detect chondrocalcinosis within knee cartilage and menisci, and to analyze the association with joint degeneration. METHODS: Subjects with radiographic knee chondrocalcinosis (n = 90, age 67.7 ± 7.3 years, 50 women) were selected from the Osteoarthritis Initiative and matched to controls without radiographic chondrocalcinosis (n = 90). Visualization of calcium-containing crystals (CaC) was compared between 3D T1-weighted gradient-echo (T1GE), 3D dual echo steady-state (DESS), 2D intermediate-weighted (IW), and proton density (PD)-weighted fast spin-echo (FSE) sequences obtained with 3T MRI and correlated with a semiquantitative CaC score obtained from radiographs...
October 4, 2016: European Radiology
https://www.readbyqxmd.com/read/27592805/avelumab-in-patients-with-chemotherapy-refractory-metastatic-merkel-cell-carcinoma-a-multicentre-single-group-open-label-phase-2-trial
#8
Howard L Kaufman, Jeffery Russell, Omid Hamid, Shailender Bhatia, Patrick Terheyden, Sandra P D'Angelo, Kent C Shih, Céleste Lebbé, Gerald P Linette, Michele Milella, Isaac Brownell, Karl D Lewis, Jochen H Lorch, Kevin Chin, Lisa Mahnke, Anja von Heydebreck, Jean-Marie Cuillerot, Paul Nghiem
BACKGROUND: Merkel cell carcinoma is a rare, aggressive skin cancer with poor prognosis in patients with advanced disease. Current standard care uses various cytotoxic chemotherapy regimens, but responses are seldom durable. Tumour oncogenesis is linked to Merkel cell polyomavirus integration and ultraviolet-radiation-induced mutations, providing rationale for treatment with immunotherapy antibodies that target the PD-L1/PD-1 pathway. We assessed treatment with avelumab, an anti-PD-L1 monoclonal antibody, in patients with stage IV Merkel cell carcinoma that had progressed after cytotoxic chemotherapy...
October 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27580439/-arthroscopic-synovectomy-of-the-wrist-in-chondrocalcinosis
#9
N Borisch
BACKGROUND: Operative treatment of chondrocalcinosis (calcium pyrophosphate dihydrate deposition disease=CPPD disease) of the wrist is hardly ever mentioned in the literature. Since the chronic, recurrent type of this disease resembles rheumatoid arthritis (RA) as well as osteoarthritis, the author has performed arthroscopic synovectomy of the wrist, which achieves excellent results in RA und offers high patient comfort as an atraumatic procedure with low morbidity. This article presents the experience made with arthroscopic synovectomy in CPPD disease of the wrist...
August 2016: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/27478398/rapid-growth-of-lung-nodules-due-to-combined-pulmonary-vasculitis-silicoanthracosis-and-chondrocalcinosis
#10
Wolfgang Jungraithmayr, Stefanos Tzafos, Oliver Distler, Antonios G A Kolios, Walter Weder, Daniel Franzen
Background. Silicoanthracosis is a pneumoconiosis due to occupational inhalation of silica and carbon dusts. Clinically, it can be associated with vasculitis or rheumatoid arthritis. In association with these diseases, silicoanthracosis can present within the lung with multiple pulmonary nodules which, as a differential diagnosis, can mimic metastatic disease or multiple abscesses. Case Presentation. We present the case of a 62-year old former pit worker with pulmonary nodules, chondrocalcinosis due to calcium pyrophosphate deposition (CPPD), and a history of renal cancer...
2016: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/27466194/the-progressive-ankyloses-protein-ank-facilitates-clathrin-and-adaptor-mediated-membrane-traffic-at-the-trans-golgi-network-to-endosome-interface
#11
Wenke Seifert, York Posor, Peter Schu, Gudrun Stenbeck, Stefan Mundlos, Sabine Klaassen, Peter Nürnberg, Volker Haucke, Uwe Kornak, Jirko Kühnisch
Dominant or recessive mutations in the progressive ankylosis gene ANKH have been linked with familial chondrocalcinosis (CCAL2), craniometaphyseal dysplasia (CMD), and mental retardation, deafness, ankylosis syndrome (MRDA). The function of the encoded membrane protein ANK in cellular compartments other than the plasma membrane is unknown. Here, we show that ANK localizes to the trans-Golgi network (TGN), clathrin-coated vesicles, and the plasma membrane. ANK functionally interacts with clathrin and clathrin associated adaptor protein (AP) complexes as loss of either protein causes ANK dispersion from the TGN to cytoplasmic endosome-like puncta...
July 27, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27339375/gitelman-syndrome-disclosed-by-calcium-pyrophosphate-deposition-disease-early-diagnosis-by-ultrasonographic-study
#12
A Zabotti, P Della Siega, L Picco, L Quartuccio, M Bassetti, S De Vita
Gitelman's syndrome is a rare autosomal-recessive tubular disorder characterized by hypomagnesemia and hypocalciuria associated to hypokalemia. The clinical spectrum is wide and usually characterized by chronic fatigue, cramps, muscle weakness and paresthesiae. We describe a case of a 43 year-old male patient with early onset of knee arthritis and no other symptoms. Ultrasound revealed diffuse and confluent hyperechoic deposits in cartilage, fibrocartilage of the menisci and synovium and calcium pyrophosphate crystals were observed in the synovial fluid of the knee...
2016: Reumatismo
https://www.readbyqxmd.com/read/27303630/case-report-cervical-chondrocalcinosis-as-a-complication-of-gitelman-syndrome
#13
Zahra Iqbal, Paul Mead, John A Sayer
Gitelman syndrome is an inherited tubulopathy leading to a hypokalaemic metabolic alkalosis with hypomagnesaemia and hypocalciuria. Most cases are due to mutations in SLC12A3, encoding the apical thiazide sensitive co-transporter in the distal convoluted tubule. Musculoskeletal effects of Gitelman syndrome are common, including muscle weakness, tetany and cramps. Chronic hypomagnesaemia can lead to chondrocalcinosis, which often affects knees but can affect other joints. Here we present a case of Gitelman syndrome complicated by cervical chondrocalcinosis leading to neck pain and numbness of the fingers...
2016: F1000Research
https://www.readbyqxmd.com/read/27263425/combining-cytology-and-microcrystal-detection-in-nonpurulent-joint-fluid-benefits-the-diagnosis-of-septic-arthritis
#14
Marine Ferreyra, Guillaume Coiffier, Jean-David Albert, Claire David, Aleth Perdriger, Pascal Guggenbuhl
OBJECTIVE: To evaluate the performance of combined cytology and microcrystal detection in joint fluid for diagnosing septic arthritis. METHODS: Retrospective single-center study of joint fluid samples from patients with manifestations suggesting acute or chronic arthritis. The absolute leukocyte count (/mm(3)) was recorded; as well as the differential counts, particularly of neutrophils (%). Microcrystals were sought and bacteriological cultures performed. Septic arthritis was defined as positive cultures of joint fluid or blood samples...
June 2, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27037810/prevalence-of-asymptomatic-chondrocalcinosis-in-the-pelvis
#15
James Derek Stensby, David A Lawrence, James T Patrie, Cree M Gaskin
OBJECTIVE: To determine trends in incidentally detected age- and gender-associated chondrocalcinosis on pelvic CT. MATERIALS AND METHODS: Twenty patients of each gender at the center of each decade of life who underwent a CT scan of the pelvis performed 2009-2013 were identified and selected for a total of 400 pelvic CTs. Images were reviewed independently by two radiologists for the presence or absence of chondrocalcinosis within the pelvis. Patients with hip or low back pain, known CPPD arthropathy or any known predisposing condition, prior hip arthroplasty, or articular fracture were excluded...
July 2016: Skeletal Radiology
https://www.readbyqxmd.com/read/27026693/chondrocalcinosis-and-gitelman-syndrome
#16
Z Iqbal, J A Sayer
No abstract text is available yet for this article.
August 2016: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/27020953/crystal-induced-arthritis-after-arthroplasty-7-cases
#17
Salim Ahmed Yahia, Valérie Zeller, Nicole Desplaces, Pascal Chazerain, Luc Lhotellier, Simon Marmor, Jean-Marc Ziza
OBJECTIVES: To describe the occurrence in prosthetic joints of crystal-induced arthritis (CIA) defined as the deposition within the synovial membrane and/or joint cavity of calcium pyrophosphate dehydrate (CPPD) (chondrocalcinosis), sodium urate (gout), or hydroxyapatite. METHODS: We retrospectively reviewed the 7 cases of prosthetic-joint CIA seen between 1993 and 2013 at a medical-surgical center specialized in the management of osteoarticular infections. RESULTS: The 4 females and 3 males ranged in age from 67 to 79 years...
October 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/26861035/the-prevalence-of-chondrocalcinosis-of-the-symphysis-pubis-on-ct-scan-and-correlation-with-calcium-pyrophosphate-dihydrate-crystal-deposition-disease
#18
Trusha Patel, Lawrence Ryan, Melissa Dubois, Guillermo Carrera, Keith Baynes, Rajeev Mannem, Jennifer Mulkerin, Alexis Visotcky
Calcium pyrophosphate dihydrate (CPP) crystal deposition in the articular cartilage can often be seen radiographically as chondrocalcinosis (CC). CPP crystals preferentially deposit in fibrocartilages such as the knee menisci and symphysis pubis (SP). We sought to determine the prevalence of CC in the SP on computed tomography (CT) of the abdomen and pelvis. This retrospective study involved readings on 1070 consecutive CTs of the abdomen and pelvis performed over 3 months in patients over 65 years of age. Medical records of 226 patients found to have CC were reviewed to determine age, gender, documentation of CPPD on problem lists or in medical histories, and whether radiology readings of the CTs mentioned CC...
March 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/26810974/aetiology-of-lateral-progression-of-arthritis-following-oxford-medial-unicompartmental-knee-replacement-a-case-control-study
#19
H Pandit, B Spiegelberg, A Clavé, C McGrath, A D Liddle, D W Murray
PURPOSE: The aim of this case-control study is to assess for predictive factors that may determine development of lateral compartment progression after Oxford medial unicompartmental knee replacement. METHODS: Twenty-eight patients who were revised as a result of lateral osteoarthritis progression were matched to 52 alive and unrevised patients. Body mass index, intra-operative findings, postoperative leg alignment, meniscal bearing size and histological findings have been analysed...
August 2016: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/26626724/calcium-pyrophosphate-deposition-disease-a-review-of-epidemiologic-findings
#20
Abhishek Abhishek
PURPOSE OF REVIEW: The purpose of this review is to summarize the recent advances in the epidemiology of calcium pyrophosphate deposition disease (CPPD), and to discuss their implications. This review is particularly timely as several epidemiological studies that enhance the understanding of CPPD have been published recently. RECENT FINDINGS: This article will review recent findings on the prevalence of chondrocalcinosis; discuss new data on the associations between bone mineral density and chondrocalcinosis; and between diuretic use, chronic kidney disease 5 and 'pseudogout' (now termed acute calcium pyrophosphate crystal arthritis)...
March 2016: Current Opinion in Rheumatology
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