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schizophrenia cognition

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https://www.readbyqxmd.com/read/29453035/changes-in-correlation-characteristics-of-time-consumption-and-mind-reading-performance-in-pre-onset-and-post-onset-psychosis
#1
TianHong Zhang, LiHua Xu, HuiRu Cui, YingYing Tang, YanYan Wei, XiaoChen Tang, XiaoHua Liu, XinMei Cao, ChunBo Li, JiJun Wang
There is a strong correlation between neurocognition and social cognition. However, none of these studies have examined the key role of time consumption during social cognition tasks. Participants included 84 individuals with clinical high risk of psychosis (CHR), 95 healthy controls (HC), and 66 case controls (schizophrenia patients, SZ), who were assessed through the Reading-Mind-in-Eyes Tasks (RMET) with computerized recording of the response time (RT). Neurocognitive tests were also performed for the HC and CHR groups...
February 7, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29453033/the-social-attribution-task-multiple-choice-sat-mc-psychometric-comparison-with-social-cognitive-measures-for-schizophrenia-research
#2
Jason K Johannesen, Joanna M Fiszdon, Andrea Weinstein, David Ciosek, Morris D Bell
The Social Attribution Task-Multiple Choice (SAT-MC) tests the ability to extract social themes from viewed object motion. This form of animacy perception is thought to aid the development of social inference, but appears impaired in schizophrenia. The current study was undertaken to examine psychometric equivalence of two forms of the SAT-MC and to compare their performance against social cognitive tests recommended for schizophrenia research. Thirty-two schizophrenia (SZ) and 30 substance use disorder (SUD) participants completed both SAT-MC forms, the Bell-Lysaker Emotion Recognition Task (BLERT), Hinting Task, The Awareness of Social Inference Test (TASIT), Ambiguous Intentions and Hostility Questionnaire (AIHQ) and questionnaire measures of interpersonal function...
February 7, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29450650/access-to-the-cns-biomarker-strategies-for-dopaminergic-treatments
#3
REVIEW
Willem Johan van den Brink, Semra Palic, Isabelle Köhler, Elizabeth Cunera Maria de Lange
Despite substantial research carried out over the last decades, it remains difficult to understand the wide range of pharmacological effects of dopaminergic agents. The dopaminergic system is involved in several neurological disorders, such as Parkinson's disease and schizophrenia. This complex system features multiple pathways implicated in emotion and cognition, psychomotor functions and endocrine control through activation of G protein-coupled dopamine receptors. This review focuses on the system-wide effects of dopaminergic agents on the multiple biochemical and endocrine pathways, in particular the biomarkers (i...
February 15, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29450447/interplay-among-psychopathologic-variables-personal-resources-context-related-factors-and-real-life-functioning-in-individuals-with-schizophrenia-a-network-analysis
#4
Silvana Galderisi, Paola Rucci, Brian Kirkpatrick, Armida Mucci, Dino Gibertoni, Paola Rocca, Alessandro Rossi, Alessandro Bertolino, Gregory P Strauss, Eugenio Aguglia, Antonello Bellomo, Martino Belvederi Murri, Paola Bucci, Bernardo Carpiniello, Anna Comparelli, Alessandro Cuomo, Domenico De Berardis, Liliana Dell'Osso, Fabio Di Fabio, Barbara Gelao, Carlo Marchesi, Palmiero Monteleone, Cristiana Montemagni, Giulia Orsenigo, Francesca Pacitti, Rita Roncone, Paolo Santonastaso, Alberto Siracusano, Annarita Vignapiano, Antonio Vita, Patrizia Zeppegno, Mario Maj
Importance: Enhanced understanding of factors associated with symptomatic and functional recovery is instrumental to designing personalized treatment plans for people with schizophrenia. To date, this is the first study using network analysis to investigate the associations among cognitive, psychopathologic, and psychosocial variables in a large sample of community-dwelling individuals with schizophrenia. Objective: To assess the interplay among psychopathologic variables, cognitive dysfunctions, functional capacity, personal resources, perceived stigma, and real-life functioning in individuals with schizophrenia, using a data-driven approach...
February 14, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29449801/lithium-inhibits-gsk3%C3%AE-and-augments-glun2a-receptor-expression-in-the-prefrontal-cortex
#5
Sarah A Monaco, Brielle R Ferguson, Wen-Jun Gao
Glycogen synthase kinase 3β (GSK3β) is a highly conserved serine/threonine kinase that has been implicated in both psychiatric and neurodegenerative diseases including schizophrenia, bipolar disorder, and Alzheimer's disease; therefore regulating its activity has become an important strategy for treatment of cognitive impairments in these disorders. This study examines the effects of lithium on GSK3β and its interaction with β-catenin and NMDA receptors within the prefrontal cortex. Lithium, a clinically relevant drug commonly prescribed as a mood stabilizer for psychiatric disorders, significantly increased levels of phosphorylated GSK3β serine 9, an inhibitory phosphorylation site, and decreased β-catenin ser33/37/thr41 phosphorylation in vitro , indicating GSK3β inhibition and reduced β-catenin degradation...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29449712/imaging-structural-and-functional-brain-development-in-early-childhood
#6
REVIEW
John H Gilmore, Rebecca C Knickmeyer, Wei Gao
In humans, the period from term birth to ∼2 years of age is characterized by rapid and dynamic brain development and plays an important role in cognitive development and risk of disorders such as autism and schizophrenia. Recent imaging studies have begun to delineate the growth trajectories of brain structure and function in the first years after birth and their relationship to cognition and risk of neuropsychiatric disorders. This Review discusses the development of grey and white matter and structural and functional networks, as well as genetic and environmental influences on early-childhood brain development...
February 16, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29447074/social-cognition-in-the-course-of-psychosis-and-its-correlation-with-biomarkers-in-a-male-cohort
#7
Evangelos Ntouros, Evangelos Karanikas, Georgios Floros, Christina Andreou, Aikaterini Tsoura, Georgios Garyfallos, Vasilios P Bozikas
INTRODUCTION: Patients diagnosed with schizophrenia display deficits in Theory of Mind (ToM) and Emotion Perception (EP) even before the appearance of full-blown symptomatology. METHODS: We evaluated ToM and EP in a male cohort consisting of 25 First Episode Psychosis (FEP) and 16 relapsed schizophrenic patients (CHRON) compared to 12 subjects in Ultra-high Risk (UHR) and 23 healthy controls (CTR). Furthermore, we measured the levels of Cortisol, Insulin like Growth Factor (IGF-1), TNF-a, TNF-b and several interleukins as potential biomarkers...
February 15, 2018: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/29445345/the-impact-of-sex-differences-on-odor-identification-and-facial-affect-recognition-in-patients-with-schizophrenia-spectrum-disorders
#8
Nilufar Mossaheb, Rainer M Kaufmann, Monika Schlögelhofer, Thushara Aninilkumparambil, Claudia Himmelbauer, Anna Gold, Sonja Zehetmayer, Holger Hoffmann, Harald C Traue, Harald Aschauer
Background: Social interactive functions such as facial emotion recognition and smell identification have been shown to differ between women and men. However, little is known about how these differences are mirrored in patients with schizophrenia and how these abilities interact with each other and with other clinical variables in patients vs. healthy controls. Methods: Standardized instruments were used to assess facial emotion recognition [Facially Expressed Emotion Labelling (FEEL)] and smell identification [University of Pennsylvania Smell Identification Test (UPSIT)] in 51 patients with schizophrenia spectrum disorders and 79 healthy controls; furthermore, working memory functions and clinical variables were assessed...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29445197/differences-in-frontotemporal-dysfunction-during-social-and-non-social-cognition-tasks-between-patients-with-autism-spectrum-disorder-and-schizophrenia
#9
Keiko Hirata, Kazuteru Egashira, Kenichiro Harada, Mami Nakashima, Masako Hirotsu, Shinji Isomura, Toshio Watanuki, Toshio Matsubara, Yoichi Kaku, Hiroshi Kaneyuki, Yoshifumi Watanabe, Koji Matsuo
Although literature evidence suggests deficits in social and non-social cognition in patients with autistic spectrum disorder (ASD) and schizophrenia (SCZ), the difference in neural correlates of the impairments between the two disorders has not been elucidated. We examined brain function in response to a non-social cognition and a social cognition task using functional near-infrared spectroscopy (fNIRS) in 13 patients with ASD, 15 patients with SCZ, and 18 healthy subjects. We assessed the brain function of participants using a verbal fluency task and an emotional facial recognition task...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444522/psychotic-symptoms-and-attitudes-toward-medication-mediate-the-effect-of-insight-on-personal-social-functions-in-patients-with-schizophrenia-one-year-randomized-controlled-trial-and-follow-up
#10
Yingjun Zheng, Yuping Ning, Shenglin She, Yongjie Deng, Yuwei Chen, Wenying Yi, Xiaodan Lu, Xinrui Chen, Juanhua Li, Ruikeng Li, Jie Zhang, Di Xiao, Haibo Wu, Chao Wu
AIMS: This study aimed to investigate the mediating pathway of 3 factors (psychotic symptoms, attitude toward medication, and cognitive processing speed) on the effect of insight on personal-social functioning in patients with schizophrenia. METHODS: Chinese inpatients with schizophrenia (n = 168; mean age 18 ± 50 years) diagnosed according to the DSM-IV were randomly assigned to treatment with antipsychotic medication alone or combined treatment. Positive and Negative Syndrome Scale (PANSS), Drug Attitude Inventory (DAI), Assessment of Insight (SAI), and Social-Personal Performance Scale (PSPS) scores were evaluated at baseline and at 3, 6, and 12 months...
February 14, 2018: Psychopathology
https://www.readbyqxmd.com/read/29442325/zic-family-proteins-in-emerging-biomedical-studies
#11
Jun Aruga
Zic family proteins have been investigated in various biomedical studies. Here we summarize the contact points between Zic proteins and recent medical research. The topics cover a wide range, reflecting the pleiotropic roles of these proteins in early embryogenesis and organogenesis. Zic1, Zic2, and Zic3 proteins play important roles in the development of axial and limb bones, and of muscles, among the derivatives of the notochord and somites. Zic1 is involved in bone's response to mechanical stress, and it also serves as a marker specific for brown adipocytes...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29440953/are-negative-symptoms-in-schizophrenia-a-distinct-therapeutic-target
#12
Octavia Oana Capatina, Ioana Valentina Miclutia
Background and aims: The relationship between negative symptoms and cognition in schizophrenia is not clear, inconsistent findings have been reported by multiple authors and meta analyses. The aim of this study was to investigate the relationship between cognition and primary negative symptoms. Methods: 67 outpatients diagnosed with schizophrenia were evaluated using PANSS and the NSA-16 scale. Correlation and regression analyses were used in the present study to investigate the relationship between the primary negative symptoms and cognition...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29440309/the-phosphodiesterase-2a-inhibitor-tak-915-ameliorates-cognitive-impairments-and-social-withdrawal-in-n-methyl-d-aspartate-receptor-antagonist-induced-rat-models-of-schizophrenia
#13
Masato Nakashima, Haruka Imada, Eri Shiraishi, Yuki Ito, Noriko Suzuki, Maki Miyamoto, Takahiko Taniguchi, Hiroki Iwashita
The pathophysiology of schizophrenia has been associated with glutamatergic dysfunction. Modulation of the glutamatergic signaling pathway, including N-methyl-D-aspartate (NMDA) receptors, can provide a new therapeutic target for schizophrenia. Phosphodiesterase 2A (PDE2A) is highly expressed in the forebrain, and is a dual substrate enzyme that hydrolyzes both cAMP and cGMP, which play pivotal roles as intracellular second messengers downstream of NMDA receptors. Here we characterize the in vivo pharmacological profile of a selective and brain penetrant PDE2A inhibitor, (N-{(1S)-1-[3-fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide) (TAK-915) as a novel treatment for schizophrenia...
February 13, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29439776/clinical-risk-factors-for-the-development-of-tardive-dyskinesia
#14
REVIEW
Marco Solmi, Giorgio Pigato, John M Kane, Christoph U Correll
BACKGROUND: Tardive dyskinesia (TD) is a severe condition that can affect almost 1 out of 4 patients on current or previous antipsychotic treatment, including both first-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs). While two novel vesicular monoamine transporter inhibitors, deutetrabenazine and valbenazine, have shown acute efficacy for TD, the majority of patients do not remit, and TD appears to recur once treatment is withdrawn. Hence, prevention of TD remains a crucial goal...
February 5, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29436320/long-term-outcomes-of-trauma-focused-treatment-in-psychosis
#15
David van den Berg, Paul A J M de Bont, Berber M van der Vleugel, Carlijn de Roos, Ad de Jongh, Agnes van Minnen, Mark van der Gaag
We present 12-month follow-up results for a randomised controlled trial of prolonged exposure and eye movement desensitisation and reprocessing (EMDR) therapy in 85 (78.8%) participants with psychotic disorder and comorbid post-traumatic stress disorder (PTSD). Positive effects on clinician-rated PTSD, self-rated PTSD, depression, paranoid-referential thinking and remission from schizophrenia were maintained up to 12-month follow-up. Negative post-traumatic cognitions declined in prolonged exposure and were stable in EMDR...
February 7, 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29432505/the-use-of-eeg-biofeedback-neurofeedback-in-psychiatric-rehabilitation
#16
REVIEW
Renata Markiewcz
The aim of the systematic review was to evaluate the use of EEG Biofeedback/Neurofeedback in patients treated for mental disorders. The review covered publications analyzing influences and effects of therapy in patients receiving psychiatric treatment based on EEG Biofeedback/Neurofeedback. Selection of publications was made by searching PubMed and Scopus databases. 328 records concerning applications of the presented method were identified in total, including 84 records for patients diagnosed with mental disorders...
December 30, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29432331/evaluation-of-the-effect-of-fluvoxamine-in-patients-with-schizophrenia-under-risperidone-treatment-a-clinical-trial
#17
Alireza Haji Seyed Javadi, Ali Akbar Shafikhani, Seyed Mohsen Zamir, Zahra Farzane Khanshir
PURPOSE/BACKGROUND: The effectiveness of selective-serotonin reuptake inhibitors in the improvement of schizophrenia is a controversial issue. The aim of this study was to evaluate the effect of fluvoxamine on the symptoms of schizophrenia including positive and negative symptoms, cognitive impairment, and quality of life. METHODS/PROCEDURES: This clinical trial was performed on 68 patients with chronic schizophrenia, treated with risperidone at 22 Bahman Hospital of Qazvin, Iran during 2015 to 2016...
February 9, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29431277/mecp2-at-hook1-mutations-in-patients-with-intellectual-disability-and-or-schizophrenia-disrupt-dna-binding-and-chromatin-compaction-in-vitro
#18
Taimoor I Sheikh, Ricardo Harripaul, Muhammad Ayub, John B Vincent
Mutations in the Methyl-CpG-binding protein-2 gene (MECP2) are commonly associated with Rett syndrome. However, it has long been appreciated that there exists a spectrum of neuropsychiatric phenotypes associated with MECP2 variants. The most frequent Rett missense mutations are located in either the methyl-CpG-binding domain (MBD) or transcription repression domain (TRD). Clinical roles for mutations in other domains such as the intervening domain (ID) or AT-Hook domains have yet to be determined. Here, we report functional analysis of MECP2 missense mutations, located in AT-Hook1 within the ID, in a large Pakistani family with childhood onset cognitive decline and schizophrenia, de novo in a girl with atypical Rett syndrome, and de novo in a woman with schizophrenia...
February 12, 2018: Human Mutation
https://www.readbyqxmd.com/read/29427913/l-carnosine-as-an-add-on-to-risperidone-for-treatment-of-negative-symptoms-in-patients-with-stable-schizophrenia-a-double-blind-randomized-placebo-controlled-trial
#19
Alireza Ghajar, Mohammad-Reza Khoaie-Ardakani, Zahara Shahmoradi, Amir-Reza Alavi, Mohsen Afarideh, Mohammad-Reza Shalbafan, Maryam Ghazizadeh-Hashemi, Shahin Akhondzadeh
Since l-carnosine has shown effectiveness in improvement of cognition in patients with schizophrenia, this 8-week, randomized, double-blind, placebo-controlled pilot study was conducted. Sixty-three patients with chronic schizophrenia, who were clinically stable on a stable dose of risperidone, entered the study. The patients were randomly assigned to l-carnosine (2 gr/day in two divided doses) or placebo for eight weeks. The patients were assessed using the positive and negative syndrome scale (PANSS), extrapyramidal symptom rating scale (ESRS), and Hamilton depression rating scale (HDRS) during the study course...
February 3, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29426848/sleep-endophenotypes-of-schizophrenia-slow-waves-and-sleep-spindles-in-unaffected-first-degree-relatives
#20
Armando D'Agostino, Anna Castelnovo, Simone Cavallotti, Cecilia Casetta, Matteo Marcatili, Orsola Gambini, Mariapaola Canevini, Giulio Tononi, Brady Riedner, Fabio Ferrarelli, Simone Sarasso
Sleep spindles and slow waves are the main brain oscillations occurring in non-REM sleep. Several lines of evidence suggest that spindles are initiated within the thalamus, whereas slow waves are generated and modulated in the cortex. A decrease in sleep spindle activity has been described in Schizophrenia (SCZ), including chronic, early course, and early onset patients. In contrast, slow waves have been inconsistently found to be reduced in SCZ, possibly due to confounds like duration of illness and antipsychotic medication exposure...
February 9, 2018: NPJ Schizophrenia
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