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https://www.readbyqxmd.com/read/28538949/the-follicular-skin-microbiome-in-patients-with-hidradenitis-suppurativa-and-healthy-controls
#1
Hans Christian Ring, Jonathan Thorsen, Ditte M Saunte, Berit Lilje, Lene Bay, Peter Theut Riis, Niels Larsen, Lee O'Brien Andersen, Henrik V Nielsen, Iben M Miller, Thomas Bjarnsholt, Kurt Fuursted, Gregor Borut Jemec
Importance: Although the pathogenesis of hidradenitis suppurativa (HS) remains enigmatic, several factors point to potential involvement of the cutaneous microbiome. Insight into the cutaneous microbiome in HS using next-generation sequencing may provide novel data on the microbiological diversity of the skin. Objective: To investigate the follicular skin microbiome in patients with HS and in healthy controls. Design, Setting, and Participants: This case-control study obtained punch biopsy specimens from patients with HS (lesional and nonlesional) and healthy controls between October 1, 2014, and August 1, 2016...
May 24, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28538945/purpuric-drug-eruptions-caused-by-epidermal-growth-factor-receptor-inhibitors-for-non-small-cell-lung-cancer-a-clinicopathologic-study-of-32-cases
#2
Yung-Tsu Cho, Kai-Lung Chen, Yi-Shuan Sheen, Che-Wen Yang, Jau-Yu Liau, Yu-Pin Cheng, Chia-Yu Chu
Importance: Purpuric skin lesions have only rarely been reported in patients receiving epidermal growth factor receptor inhibitors. However, their clinical and histopathologic presentations have varied considerably. Objective: To characterize purpuric skin eruptions caused by epidermal growth factor receptor inhibitors. Design, Setting, and Participants: This prospective study enrolled 32 patients who presented to an integrated dermato-oncologic clinic in a tertiary referral medical center with purpuric skin lesions after using epidermal growth factor receptor inhibitors from January 1, 2013, through December 31, 2015...
May 24, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28538878/hidradenitis-suppurativa-epidemiological-study-of-cases-diagnosed-at-a-dermatological-reference-center-in-the-city-of-bauru-in-the-brazilian-southeast-state-of-s%C3%A3-o-paulo-between-2005-and-2015
#3
Tatiana Cristina Pedro Cordeiro de Andrade, Bruna Cortinóvis Vieira, Agnes Mayumi Nakano Oliveira, Tábata Yamasaki Martins, Tatiane Meira Santiago, Antônio Carlos Ceribelli Martelli
Background: Hidradenitis is a chronic inflammatory disease of the hair follicles. A treatment is necessary due to chronicity and psychological changes that patient present. Objective: To investigate epidemiological aspects and elaborate a risk group profile, promote early diagnosis and contribute to the knowledge about the disease. Methods: This cross-sectional descriptive study with retrospective analysis of medical records of 194 patients diagnosed with hidrosadenitis in a dermatological reference center in the city of Bauru (SP) between 2005 and 2015...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28538867/preval%C3%A3%C2%AAncia-de-infec%C3%A3-%C3%A3-o-por-helicobacter-pylori-em-uma-comunidade-ind%C3%A3-gena-em-s%C3%A3-o-paulo-e-fatores-associados-estudo-transversalprevalence-of-helicobacter-pylori-infection-in-an-indigenous-community-in-s%C3%A3-o-paulo-and-associated-factors-cross-sectional-study
#4
Juliana Rejane da Silva Roque, Rodrigo Strehl Machado, Douglas Rodrigues, Patrícia Rech, Elisabete Kawakami
CONTEXT AND OBJECTIVE: The prevalence of Helicobacter pylori infection is unevenly distributed among different populations. The aim here was to evaluate the factors associated with Helicobacter pylori infection among children up to five years of age living in a high-risk community. DESIGN AND SETTING: Cross-sectional study in an indigenous community of Guarani Mbya ethnicity, Tekoa Ytu and Tekoa Pyau villages, Jaraguá district, city of São Paulo (SP), Brazil. METHODS: 74 children aged 0...
March 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28538851/-antimicrobial-sensitivity-of-the-environmental-microbiota-in-the-intensive-care-units-of-a-peruvian-hospital
#5
José Díaz-Tello, Jesús Rojas-Jaimes, Jimmy Ibarra-Trujillo, Delza Tárraga-Gonzales
The objective was to detect Gram-negative bacilli and Gram-positive cocci isolated from the environmental microbiota of the Intensive Care Unit (ICU) departments of Neonatology, Pediatrics, and Transplants (kidney, liver, and general) in a Lima hospital and determine their antimicrobial sensitivity. Eighty samples were obtained from inanimate surfaces using a wet swab. A total of 61 bacterial strains were identified, including Staphylococcus epidermis (46.0%), Alcaligenes sp. (21.3%), Pseudomonas aeruginosa (16...
January 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28538809/self-medication-among-nursing-students-in-the-state-of-amazonas-brazil
#6
Abel Santiago Muri Gama, Silvia Regina Secoli
Objective: To determine the prevalence of self-medication and associated factors among nursing students. Method: This is a cross-sectional study with 116 nursing students from the public university in the state of Amazonas, Brazil, from March to April 2014. Data were collected using a questionnaire with socioeconomic and medicine use variables. The data were subjected to bivariate analysis and logistic regression at a significance level of 5%. Results: The prevalence of self-medication was 76...
May 18, 2017: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/28538746/medical-management-of-hidradenitis-suppurativa
#7
Lauren Av Orenstein, Robert G Micheletti
Hidradenitis suppurativa is a chronic inflammatory disease of the folliculo-infundibular unit for which no individual treatment is uniformly effective. A wide array of therapies has been reported successful in the treatment of hidradenitis, although few high-quality clinical trials have been conducted. Comparing the effectiveness of different therapies has proven challenging due to heterogeneity and limited validation of outcome measures. We performed a systematic review of clinical trials of medical treatments for hidradenitis, yielding 8 articles reporting on 9 trials of antibiotic, hormonal, and biologic therapies...
June 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28538684/magnetic-nanoparticles-for-antibiotics-detection
#8
REVIEW
Cecilia Cristea, Mihaela Tertis, Ramona Galatus
Widespread use of antibiotics has led to pollution of waterways, potentially creating resistance among freshwater bacterial communities. Microorganisms resistant to commonly prescribed antibiotics (superbug) have dramatically increased over the last decades. The presence of antibiotics in waters, in food and beverages in both their un-metabolized and metabolized forms are of interest for humans. This is due to daily exposure in small quantities, that, when accumulated, could lead to development of drug resistance to antibiotics, or multiply the risk of allergic reaction...
May 24, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28538360/consort-may-stereotactic-intracavity-administration-of-antibiotics-shorten-the-course-of-systemic-antibiotic-therapy-for-brain-abscesses
#9
Xin Yu, Rui Liu, Yaming Wang, Hulin Zhao, Jinhui Chen, Jianning Zhang, Chenhao Hu
BACKGROUND: Despite advances in surgical techniques in the management of the brain abscess, continuous systemic long-term antibiotics are necessary and crucial. This study was designed to evaluate the effect of intracavity administration of high-dose antibiotics on the course of antibiotic therapy. METHODS: Between 2003 and 2013, 55 patients with bacterial brain abscesses (83 abscesses) were treated with stereotactic aspiration and intracavity injection of high-dose antibiotics combined with a short course systemic antibiotic therapy...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28538018/low-serum-angiopoietin-1-high-serum-angiopoietin-2-and-high-ang-2-ang-1-protein-ratio-are-associated-with-early-onset-sepsis-in-surinamese-newborns
#10
Rens Zonneveld, Rianne Jongman, Amadu Juliana, Wilco Zijlmans, Frans Plötz, Grietje Molema, Matijs van Meurs
PURPOSE: Vascular inflammation and leakage in sepsis is mediated by Angiopoietin-1 (Ang-1) and -2 (Ang-2) and their phosphorylation of the endothelial Tie-2 receptor. Levels of Ang-2 change in adults and children during sepsis, which is associated with severity of sepsis. This study investigates levels of Ang-1 and Ang-2 in newborns to gain insight in the vascular pathophysiology of early onset sepsis (EOS) within 72 hours after birth. METHODS: A prospective cohort study was performed amongst 71 Surinamese newborns treated with antibiotics for suspected EOS and 20 control newborns...
May 22, 2017: Shock
https://www.readbyqxmd.com/read/28537857/cost-effectiveness-analysis-of-using-dermatologists-versus-pediatricians-to-treat-mild-to-moderate-acne
#11
Scott A Davis, Sebastian Himmler, Steven R Feldman
OBJECTIVE: To assess the cost-effectiveness from the payer perspective of using dermatologists versus pediatricians to treat acne in adolescents ages 10-18. METHODS: A Markov model was constructed to explore outcomes over a 2-year period from the US private payer perspective. Patients ages 10-18 with acne entered the model under the "dermatologist"and "pediatrician" conditions. In each 3-month cycle,each modeled patient received topical retinoids,benzoyl peroxide (BP), antibiotics, or no treatment,and could progress to an acne-free state or remain in an acne state...
May 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28537778/antibacterial-susceptibilities-of-escherichia-coli-from-community-acquired-urinary-tract-infections-in-the-faroe-islands-associations-with-antibacterial-sales-and-comparison-with-iceland-and-denmark
#12
Marita Debess Magnussen, Hannes Gislason, Shahin Gaini, Karl G Kristinsson
Currently, data on Escherichia coli antibacterial susceptibilities in the Faroe Islands are lacking. The aim was to investigate the antibacterial susceptibilities of E. coli from patients with community-acquired urinary tract infections in the Faroe Islands, correlate with antibacterial sales, and compare with Iceland and Denmark. From 2009 to 2010 and in 2012, 12 general practitioners from the Faroe Islands were recruited to provide urine samples from patients. Antibacterial susceptibilities were determined by disc diffusion testing according to the Clinical and Laboratory Standards Institute methods and criteria...
May 24, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28535607/generation-of-the-new-discovered-resistant-gene-mcr-1-knockout-in-escherichia-coli-using-crispr-cas9-system
#13
Lichang Sun, Tao He, Lili Zhang, Maoda Pang, Qiaoyan Zhang, Yan Zhou, Hongduo Bao, Ran Wang
The mcr-1 gene was the new discovered "superbug" gene which makes the bacteria highly resistant to the last-resort class of antibiotics in China in 2016. The mcr-1 gene raised serious concern about its possible global dissemination and spread. Here, we report a potential anti-resistant strategy that CRISPR/Cas9 mediated approach can efficiently induce mcr-1 gene knockout in Escherichia coli. Our findings suggested that using CRISPPR/Cas9 system to knockout the resistant gene mcr-1 might be a potential anti-resistant strategy...
May 24, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28535485/quantification-of-residual-antibiotics-in-cow-manure-being-spread-over-agricultural-land-and-assessment-of-their-behavioral-effects-on-antibiotic-resistant-bacteria
#14
Ji-Ran Yeom, Soon-Uk Yoon, Chang-Gyun Kim
Antibiotic resistant bacteria (ARB) in livestock manure used as fertilizer and spread over agriculture land, may pose a threat to the health of humans. Considering this, the concentrations of tetracycline (TC), oxytetracycline (OTC), and sulfathiazole (STZ) in the surface soil were quantified using LC-MS. These antibiotics have been used in livestock and are found in fertilizer produced from livestock excretions. Species of ABR were identified using 16S rDNA. Soil samples were collected at depths of 0, 7, and 15 cm from farmland in Incheon (South Korea)...
May 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/28535470/pharmacophore-guided-discovery-of-small-molecule-interleukin-15-inhibitors
#15
Barbara Żyżyńska-Granica, Bartosz Trzaskowski, Szymon Niewieczerzał, Sławomir Filipek, Oliwia Zegrocka-Stendel, Małgorzata Dutkiewicz, Piotr Krzeczyński, Magdalena Kowalewska, Katarzyna Koziak
Upregulation of interleukin 15 (IL-15) contributes directly i.a. to the development of inflammatory and autoimmune diseases. Selective blockade of IL-15 aimed to treat rheumatoid arthritis, psoriasis and other IL-15-related disorders has been recognized as an efficient therapeutic method. The aim of the study was to identify small molecules which would interact with IL-15 or its receptor IL-15Rα and inhibit the cytokine's activity. Based on the crystal structure of IL-15Rα·IL-15, we created pharmacophore models to screen the ZINC database of chemical compounds for potential IL-15 and IL-15Rα inhibitors...
May 12, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28535440/management-of-ventilator-associated-pneumonia-with-a-new-antibiotic-adjuvant-entity-ceftriaxone-sulbactam-disodium-edetate-a-novel-approach-to-spare-carbapenems
#16
Prachee Sathe, Sagar Maddani, Shilpa Kulkarni, Nita Munshi
BACKGROUND: Ventilator associated pneumonia (VAP) is one of the most serious nosocomial infections in Intensive Care Unit (ICU). The aim of this study was to evaluate a new approach to spare the carbapenems for the management of patients diagnosed with VAP due to Acinetobacter baumannii (A. baumannii). METHOD: This retrospective study was conducted on VAP patients presenting for treatment at tertiary care centre between May 2014 and March 2016. The case sheets of patients who have been treated for VAP with meropenem, antibiotic adjuvant entity (AAE) and colistin were analysed...
May 15, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28535362/tympanostomy-tube-placement-vs-medical-management-for-recurrent-acute-otitis-media-in-tricare-insured-children
#17
Nikhila Raol, Meesha Sharma, Emily F Boss, Wei Jiang, John W Scott, Peter Learn, Joel S Weissman
Objective To compare number of infections and health care utilization in children insured by TRICARE with recurrent acute otitis media (RAOM) managed surgically with tympanostomy tube (TT) placement compared with those managed medically. Study Design Retrospective matched cohort study. Setting TRICARE claims database from 2006 to 2010. Subjects and Methods We matched TRICARE beneficiaries ≤5 years of age diagnosed with RAOM who underwent TT placement with those managed medically using 1:1 coarsened-exact matching on age, sex, race, sponsor rank, and region...
May 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28535271/measuring-trachomatous-inflammation-intense-ti-when-prevalence-is-low-provides-data-on-infection-with-chlamydia-trachomatis
#18
Andrea I Zambrano, Beatriz E Muñoz, Harran Mkocha, Laura Dize, Charlotte A Gaydos, Thomas Quinn, Sheila K West
Purpose: Clinical trachoma is the current measure of effectiveness of antibiotic and environmental improvements in trachoma endemic communities. Impact assessments measure only trachomatous inflammation-follicular (TF). Trachomatous inflammation-intense (TI) is not used for decisions on stopping mass drug administration (MDA) or achieving intervention goals. We tested the supposition that TI was not associated with Chlamydia trachomatis when disease prevalence is low. Methods: In 35 communities undergoing MDA as part of a larger project, 110 children ages 1 to 9 years were randomly selected in each community for surveys at baseline, 6, and 12 months...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28535139/otitis-media-with-effusion-our-national-practice
#19
Rachel E Roditi, Richard M Rosenfeld, Jennifer J Shin
Otitis media with effusion (OME) is the focus of an updated multidisciplinary clinical practice guideline published by the American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) and the American Academy of Pediatrics (AAP). Based on data from clinical trials, the guideline recommends against using antihistamines, antibiotics, oral steroids, and intranasal steroids for OME. To understand practice patterns related to these guidelines, we assessed nationally representative data. Despite controlling for age, sex, race/ethnicity, and other potential confounders individualized for each medication class, an increased risk of antihistamine (odds ratio [OR], 3...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28534807/lobophorin-k-a-new-natural-product-with-cytotoxic-activity-produced-by-streptomyces-sp-m-207-associated-with-the-deep-sea-coral-lophelia-pertusa
#20
Alfredo F Braña, Aida Sarmiento-Vizcaíno, Miguel Osset, Ignacio Pérez-Victoria, Jesús Martín, Nuria de Pedro, Mercedes de la Cruz, Caridad Díaz, Francisca Vicente, Fernando Reyes, Luis A García, Gloria Blanco
The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Avilés Canyon. Its structure was determined using a combination of spectroscopic techniques, mainly ESI-TOF MS and 1D and 2D NMR. This new natural product displayed cytotoxic activity against two human tumor cell lines, such as pancreatic carcinoma (MiaPaca-2) and breast adenocarcinoma (MCF-7)...
May 19, 2017: Marine Drugs
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