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https://www.readbyqxmd.com/read/29792351/peroxiredoxin-6-inhibits-osteogenic-differentiation-and-bone-formation-through-human-dental-pulp-stem-cells-and-induces-delayed-bone-development
#1
Kyung-Ran Park, Hyung-Mun Yun, In Jun Yeo, Sehyung Cho, Jin Tae Hong, Yong Seok Jeong
AIMS: Peroxiredoxins (PRDXs) are thiol-specific antioxidant enzymes that regulate redox balance that are critical for maintaining the cellular potential for self-renewal and stemness. Stem cell-based regenerative medicine is a promising approach in tissue reconstruction. However, to obtain functional cells for use in clinical applications, stem cell technology still requires improvements. RESULTS: In the present study, we found that PRDX6 levels were decreased during osteogenic differentiation in human dental pulp stem cells (hDPSCs)...
May 24, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29792040/lung-cancer-screening-with-mri-characterization-of-nodules-with-different-non-enhanced-mri-sequences
#2
Michael Meier-Schroers, Rami Homsi, Hans Heinz Schild, Daniel Thomas
Background There is increased interest in pulmonary magnetic resonance imaging (MRI) as a radiation-free alternative to computed tomography (CT) for lung cancer screening. Purpose To analyze MRI characteristics of pulmonary nodules with different non-enhanced sequences. Material and Methods Eighty-two participants of a lung cancer screening were included. MRI datasets of 32 individuals with 46 different nodules ≥ 6 mm were prospectively evaluated together with 50 controls by two readers. Acquired sequences were T2- short tau inversion recovery (STIR), T2, balanced steady-state free precession (bSSFP), 3D-T1, and diffusion-weighted imaging (DWI)...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29791966/outcomes-of-bethesda-categories-iii-and-iv-thyroid-nodules-over-5-years-and-performance-of-the-afirma-gene-expression-classifier-a-single-institution-study
#3
Kelsi E Deaver, Bryan R Haugen, Nikita Pozdeyev, Carrie B Marshall
OBJECTIVE: The second edition Bethesda System for Reporting Thyroid Cytology estimates 6-18% malignancy rate of category III (B3) and 10-40% for category IV (B4) nodules; however, reported malignancy rates have considerable variability among institutions. Use of molecular classifiers (including Afirma Gene Expression Classifier, GEC) can be utilized in management of thyroid nodules. Our objective was to analyze malignancy rates of B3 and B4 nodules and determine clinical outcomes of GEC Benign nodules...
May 23, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29791554/chest-x-ray-and-chest-ct-findings-in-patients-diagnosed-with-pulmonary-tuberculosis-following-solid-organ-transplantation-a-systematic-review
#4
Irai Luis Giacomelli, Roberto Schuhmacher Neto, Edson Marchiori, Marisa Pereira, Bruno Hochhegger
The objective of this systematic review was to select articles including chest X-ray or chest CT findings in patients who developed pulmonary tuberculosis following solid organ transplantation (lung, kidney, or liver). The following search terms were used: "tuberculosis"; "transplants"; "transplantation"; "mycobacterium"; and "lung". The databases used in this review were PubMed and the Brazilian Biblioteca Virtual em Saúde (Virtual Health Library). We selected articles in English, Portuguese, or Spanish, regardless of the year of publication, that met the selection criteria in their title, abstract, or body of text...
April 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29791543/rapidly-growing-pulmonary-ground-glass-nodule-caused-by-metastatic-melanoma-lacking-uptake-on-18f-fdg-pet-ct
#5
Giorgia Dalpiaz, Sofia Asioli, Stefano Fanti, Gaetano Rea, Edson Marchiori
No abstract text is available yet for this article.
April 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29791416/oncological-outcomes-in-extended-time-intervals-betweenpreoperative-chemoradiotherapy-with-capecitabine-and-surgery-inoperable-rectal-adenocarcinoma
#6
Miguel A Muñoz, Manuel G Palacios, Jenny Malca, Raúl Mantilla, Paola C Montenegro, Ivan Chavez
OBJECTIVE: To assess whether extended time intervals (8-12, 13-20 and >20 weeks) between the end of neoadjuvant chemoradiotherapy and surgery affect overall survival, disease-free survival. MATERIALS AND METHODS: Retrospective study in 120 patients with rectal adenocarcinoma without evidence of metastasis (T1-4/N0-2/M0) at the time of diagnosis that underwent surgery with curative intent after neoadjuvant chemoradiotherapy with capecitabine and obtained R0 or R1 resection between January 2010 to December 2014 at the National Cancer Institute of Peru...
January 2018: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29791206/effect-of-ct-window-settings-on-size-measurements-of-the-solid-component-in-sub-solid-nodules-evaluation-of-prediction-efficacy-of-the-degree-of-pathological-malignancy-in-lung-adenocarcinoma
#7
Shi-Yuan Liu, Qiong Li, Ya-Feng Gu, Li Fan, Qing-Chu Li, Yi Xiao
To investigate the predictive value of size measurements of the solid components in pulmonary subsolid nodules with different CT window settings and to evaluate the degree of pathological malignancy in lung adenocarcinoma.  Methods: The preoperative chest CT images and pathological data of 125 patients were retrospectively evaluated. The analysis included 127 surgically resected lung adenocarcinomas that manifested as subsolid nodules. All subsolid nodules were divided into two groups: 69 in group A, including 22 adenocarcinomas in situ (AIS) and 47 minimally invasive adenocarcinomas (MIA); 58 in group B that included invasive pulmonary adenocarcinomas (IPA)...
May 23, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29791072/massive-hemothorax-after-computed-tomography-guided-lung-tumor-biopsy-an-unusual-but-disastrous-complication
#8
Wei-Ming Huang, Hui-Chen Lin, Chia-Hung Chen, Chien-Wen Chen, Chih-Hsin Wang, Chung-Yao Huang, Ching-Che Wang, Chun-Chao Huang
Intercostal artery injury during transthoracic puncture is rare but is accompanied by high rates of morbidity and mortality. We report a case with metachronous double primary esophageal cancers and development of multiple lung nodules. Tissue proof for the lung nodules is required to guide the following treatment protocol. Our patient died soon after computed tomography-guided lung tumor biopsy was performed, as a result of procedure-related massive and uncontrolled hemothorax. The cause is likely intercostal artery injury related to the transthoracic puncture...
May 23, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29791027/phenotypical-and-molecular-changes-in-nodule-in-nodule-hepatocellular-carcinoma-with-pathogenetical-implications
#9
Noemi Rudini, Chiara Novello, Annarita Destro, Elena Riboldi, Matteo Donadon, Luca Viganò, Emanuela Morenghi, Massimo Roncalli, Luca Di Tommaso
BACKGROUND: Nodule in nodule hepatocellular carcinoma (N/N HCC) is a convincing proof of multistep hepatocarcinogenesis. In this lesion, an inner HCC develops within an outer more differentiated tumor, which can be rapidly taken over by the former so that N/N HCC is rarely detected. METHODS AND RESULTS: Ten resected N/N HCC in cirrhosis characterized, as outer lesions, by early (n.3) and G1 (n.7) HCC and, as inner lesions, by G1 (n.3) and G2 (n.7) HCC. The largest/smallest diameters of outer and inner nodules were, respectively, 20/6 and 16/4 mm...
May 23, 2018: Histopathology
https://www.readbyqxmd.com/read/29790450/opisthotonos-and-unilateral-internal-hydrocephalus-associated-with-aberrant-migration-of-serratospiculum-sp-or-serratospiculoides-sp-in-a-prairie-falcon
#10
Arnaud J Van Wettere, Jaqueline P Kurz, Amanda Wilhelm, Jay Dee Ipsen
A juvenile, wild-caught prairie falcon ( Falco mexicanus) kept for falconry was presented to a veterinary hospital for intermittent opisthotonos and torticollis. Clinical examination, complete blood count, serum biochemistry panel, and fecal analysis were unremarkable. Clinical signs did not resolve, and the bird was euthanized 6 mo after the appearance of clinical signs. Autopsy revealed a mild, unilateral hydrocephalus and nematodes within the thoracic air sac. Histopathology demonstrated mild, unilateral hydrocephalus; scattered glial nodules; meningeal nematode sections; and meningeal and intraventricular embryonated eggs...
May 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29790102/classification-of-malignant-and-benign-lung-nodules-using-taxonomic-diversity-index-and-phylogenetic-distance
#11
Robherson Wector de Sousa Costa, Giovanni Lucca França da Silva, Antonio Oseas de Carvalho Filho, Aristófanes Corrêa Silva, Anselmo Cardoso de Paiva, Marcelo Gattass
Lung cancer presents the highest cause of death among patients around the world, in addition of being one of the smallest survival rates after diagnosis. Therefore, this study proposes a methodology for diagnosis of lung nodules in benign and malignant tumors based on image processing and pattern recognition techniques. Mean phylogenetic distance (MPD) and taxonomic diversity index (Δ) were used as texture descriptors. Finally, the genetic algorithm in conjunction with the support vector machine were applied to select the best training model...
May 23, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29789911/the-role-of-core-needle-biopsy-in-the-diagnosis-of-initially-detected-thyroid-nodules-a-systematic-review-and-meta-analysis
#12
Sae Rom Chung, Chong Hyun Suh, Jung Hwan Baek, Young Jun Choi, Jeong Hyun Lee
OBJECTIVES: To systematically review the published literature and evaluate the efficacy and safety of core needle biopsy (CNB) for initially detected thyroid nodules. METHODS: The Ovid-MEDLINE and Embase databases were searched for studies evaluating CNB for the diagnosis of initially detected thyroid nodules. A meta-analysis was performed to evaluate non-diagnostic results, inconclusive results and diagnostic accuracy for a diagnosis of malignancy with CNB. To overcome heterogeneity, multiple subgroup analyses were performed...
May 22, 2018: European Radiology
https://www.readbyqxmd.com/read/29789808/the-value-of-18-f-fdg-pet-ct-mathematical-prediction-model-in-diagnosis-of-solitary-pulmonary-nodules
#13
Ling Wang, Yao Chen, Kun Tang, Jie Lin, Hong Zhang
Purpose: To establish an 18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT) mathematical prediction model to improve the diagnosis of solitary pulmonary nodules (SPNs). Materials and Methods: We retrospectively reviewed 177 consecutive patients who underwent 18 F-FDG PET/CT for evaluation of SPNs. The mathematical model was established by logistic regression analysis. The diagnostic capabilities of the model were calculated, and the areas under the receiver operating characteristic curve (AUC) were compared with Mayo and VA model...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29789629/non-coding-rnas-in-various-stages-of-liver-disease-leading-to-hepatocellular-carcinoma-differential-expression-of-mirnas-pirnas-lncrnas-circrnas-and-sno-mt-rnas
#14
Srinivas V Koduru, Ashley N Leberfinger, Yuka I Kawasawa, Milind Mahajan, Niraj J Gusani, Arun J Sanyal, Dino J Ravnic
Hepatocellular carcinoma (HCC) was the fifth leading cause of cancer death in men and eighth leading cause of death in women in the United States in 2017. In our study, we sought to identify sncRNAs in various stages of development of HCC. We obtained publicly available small RNA-seq data derived from patients with cirrhosis (n = 14), low-grade dysplastic nodules (LGDN, n = 9), high grade dysplastic nodules (HGDN, n = 6), early hepatocellular carcinoma (eHCC, n = 6), and advanced hepatocellular carcinoma (HCC, n = 20), along with healthy liver tissue samples (n = 9)...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789443/low-intensity-pulsed-ultrasound-stimulation-facilitates-in-vitro-osteogenic-differentiation-of-human-adipose-derived-stem-cells-via-up-regulation-of-heat-shock-protein-hsp-70-hsp90-and-bone-morphogenetic-protein-bmp-signaling-pathway
#15
Zhonglei Zhang, Yalin Ma, Shaowen Guo, Yi He, Gang Bai, Wenjun Zhang
Low-intensity pulsed ultrasound (LIPUS) has positive effects on osteogenic differentiation. However, the effect of LIPUS on osteogenic differentiation of human adipose-derived stem cells (hASCs) is unclear. In the present study, we investigated whether LIPUS could promote the proliferation and osteogenic differentiation of hASCs. hASCs were isolated and osteogenically induced with LIPUS stimulation at 20 and 30 mW cm-2 for 30 min day-1 Cell proliferation and osteogenic differentiation potential of hASCs were respectively analyzed by cell counting kit-8 assay, Alizarin Red S staining, real-time polymerase chain reaction, and Western blotting...
May 29, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29788999/the-first-case-of-multiple-pulmonary-granulomas-with-amyloid-deposition-in-a-dental-technician-a-rare-manifestation-as-an-occupational-lung-disease
#16
Taizou Hirano, Tadahisa Numakura, Hiroshi Moriyama, Ryoko Saito, Yutaka Shishikura, Jun Shiihara, Hisatoshi Sugiura, Masakazu Ichinose
BACKGROUND: Occupational lung diseases, such as pneumoconiosis, are one of the health problems of dental workers that have been receiving increasing interest. Pulmonary amyloidosis is a heterogenous group of diseases, and can be classified into primary (idiopathic) and secondary (associated with various inflammatory diseases, hereditary, or neoplastic). To date, the development of pulmonary amyloidosis in dental workers has not been reported. CASE PRESENTATION: A 58-year-old Japanese female presented with chest discomfort and low-grade fever that has persisted for 2 months...
May 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29788927/chronic-kirschsteiniothelia-infection-superimposed-on-a-pre-existing-non-infectious-bursitis-of-the-ankle-the-first-case-report-of-human-infection
#17
Masanori Nishi, Ichiro Okano, Takatoshi Sawada, Yasuka Hara, Kiwamu Nakamura, Katsunori Inagaki, Takashi Yaguchi
BACKGROUND: Kirschsteiniothelia is a saprophytic fungus that is abundantly present in the environment. To date, there have been no reports of human infection caused by this fungus. We report a case of Kirschsteiniothelia infection superimposed on a pre-existing non-infectious bursitis of the ankle. CASE PRESENTATION: An 81-year-old immunocompetent female local farmer noticed the presence of a nodule on her right ankle 5 years before her first visit to our hospital...
May 22, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29788738/hashimoto-s-thyroiditis-nodular-goiter-or-follicular-adenoma-combined-with-papillary-thyroid-carcinoma-play-protective-role-in-patients
#18
H Ma, L Li, K Li, T Wang, Y Zhang, C Zhang, Y Xu, X Wu, J Yu, H Wang, B Xiang, R Zhang, W Wang
Papillary thyroid carcinoma (PTC) is often combined with other types of thyroid disease, such as Hashimoto's thyroiditis(HT), nodular goiter(NG), Follicular adenoma(FA) and other types. However, the function of these diseases in PTC tumorigenesis and development is not well understood. In this research, 563 PTC patients were recruited and divided into two groups according to pathological diagnosis, namely simple PTC (PTC) and PTC combined with other thyroid diseases (PTC+). Clinicopathological characteristics and BRAFV600E mutation status were compared between PTC and PTC+...
March 14, 2018: Neoplasma
https://www.readbyqxmd.com/read/29788513/-granular-cell-tumor-of-the-lung-a-visual-diagnosis-on-bronchoscopy
#19
S Keymel, S Büter, S Krüger
A 38 years old patient presented with a progressive reduction of his general condition and weight loss. Chest imaging revealed consolidations and cavities suggesting a mycobacterial infection. For further diagnosis, a bronchoscopy was performed. In fact, a nontuberculous mycobacterial infection was found. As an incidental finding, we saw a white polypoid tumor in the middle lobe bronchus. The histology of this tumor revealed a granular cell tumor (GCT). The GCT is a rare tumor entity which occurs at different anatomical locations...
May 22, 2018: Pneumologie
https://www.readbyqxmd.com/read/29788139/microsurgical-resection-of-spinal-cord-hemangioblastoma-2-dimensional-operative-video
#20
Mirza Pojskic, Kenan I Arnautovic
This video demonstrates microsurgical resection of spinal cord hemangioblastoma. Hemangioblastomas are rare, benign, highly vascularized tumors classified as grade I according to World Health Organization classification systems. About 3% of all intramedullary tumors are hemangioblastomas.1,2 Spinal cord hemangioblastomas are either sporadic3,4 or manifestations of von Hippel-Lindau (VHL) disease in 20% to 45% of patients.5,6 A 30-year-old male presented with sudden onset urinary incontinence. Magnetic resonance imaging showed contrast enhancing intramedullary tumor with adjacent cyst in T11, and syringomyelia extending to C1...
May 18, 2018: Operative Neurosurgery (Hagerstown, Md.)
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