Read by QxMD icon Read


Ersan Arda, Ilkan Yuksel, Basri Cakiroglu, Esra Akdeniz, Nusret Cilesiz
Introduction We investigated the association of the neutrophil/lymphocyte ratio (NLR) with tumor size and Fuhrman grade in nonmetastatic renal cell carcinoma (RCC) cases. Materials and methods Data of nonmetastatic RCC (T1-4N0M0) cases, operated between 2010 and 2016, were retrospectively reviewed and 103 patients were included in the study. The patients were divided into two groups according to tumor diameter (Group 1 T < 4 cm, Group 2 T ≥ 4 cm) and into three groups according to Fuhrman grade. Twenty-eight patients with a tumor diameter of 4 cm or less in Group 1 and 75 patients with a tumor diameter greater than 4 cm in Group 2 were compared...
January 10, 2018: Curēus
Kyungyong Choi, Hyunryul Ryu, Katherine J Siddle, Anne Piantadosi, Lisa Freimark, Daniel J Park, Pardis Sabeti, Jongyoon Han
In blood samples from patients with viral infection, it is often important to separate viral particles from human cells, for example to minimize background in performing viral whole genome sequencing. Here, we present a microfluidic device that uses spiral inertial microfluidics with continuous circulation to separate host cells from viral particles and free nucleic acid. We demonstrate that this device effectively reduces white blood cells, red blood cells, and platelets from both whole blood and plasma samples with excellent recovery of viral nucleic acid...
March 14, 2018: Analytical Chemistry
Kali G Makedou, Eleni Vagdatli, Evangelia Patziarela, Vasiliki Konstantinidou, Eirini Poimenidou, Evgenia Lymperaki
BACKGROUND: Orthodox Christian believers fast abstaining from meat, eggs, dairy products or even fish and oil in certain days of the fasting period, three times a year. AIM: The present study aimed to investigate the impact of a 48-day fast before Easter in blood count parameters, coagulation and antioxidant status. MATERIAL AND METHODS: A total of 35 healthy volunteers, 19-66 years old, were included in the study. White blood cells (WBC), lymphocytes (Lymph), granulocytes (Gran), haemoglobin (Hb), hematocrit (Ht), red blood cells (RBC), mean erythrocyte volume (MCV), platelets (Plt), were measured...
February 15, 2018: Open Access Macedonian Journal of Medical Sciences
Gian Lorenzo D'Alterio, Chris Barichievy, William Macasero
BACKGROUND: The Arabian Sand Gazelle (Gazella subgutturosa marica, Thomas, 1897) has been extirpated throughout the Arabian Peninsula. Captive breeding and reintroduction for conservation purposes require veterinary support and the use of hematology RIs. OBJECTIVES: The purpose of the study was to establish hematological RIs for the Arabian Sand Gazelle. METHODS: Blood from 231 clinically healthy captive and 22 wild (reintroduced) Arabian Sand Gazelles were sampled...
March 7, 2018: Veterinary Clinical Pathology
Sarah Hintermair, Elisabeth Zwickl-Traxler, Martin Pecherstorfer, Josef Singer
Myeloproliferative neoplasms (MPN), classified as polycythemia vera (PV), essential thrombocytosis (ET) and myelofibrosis (MF) are stem-cell derived disorders. Mutations in either the januskinase-2 (JAK-2) or the calreticulin (CALR) gene are characteristic for MPN and may result in enhanced proliferation of red blood cells, white blood cells and platelets, and thus increase the risk for vascular events. This study is a retrospective and descriptive analysis of records of patients, who underwent treatment for myeloproliferative syndromes at the Department of Hemato-Oncology of the University hospital Krems from 2008 to the end of 2015...
February 2, 2018: Oncotarget
Rainer Moog, Remo Rothe, Nicole Arlt, Thomas Burkhardt
INTRODUCTION: Platelet additive solutions (PAS) allow to maintain platelet storage properties in platelet concentrates (PCs). The aim of the present study was to evaluate the in-vitro quality of irradiated and non-irradiated PCs, suspended in PAS, over a storage period of 6 days. METHODS: Plateletpheresis donors fulfilling current eligibility criteria underwent plateletpheresis with the MCS+ blood cell separator. The PAS SSP+ was used to store platelets (PLT) for up to 6 days...
February 9, 2018: Transfusion and Apheresis Science
Mahmoud M Elgari, Omar F Khabour, Samaher M Alhag
Preeclampsia is a condition that might severely impact the health of mothers and their newborns. The aim of this investigation is to examine hematological parameters in mothers with preeclampsia and umbilical cord blood. Eighty preecalmptic mothers were recruited in the study. In addition, eighty normal pregnant mothers served as controls. Hematological parameters that include hemoglobin (Hb), red blood cell count (RBC), red cell distribution width (RDW), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), white blood cell counts (WBC), platelet counts, mean platelet volume (MPV) and Platelet large cell ratio (PLCR) were examined...
February 23, 2018: Clinical and Experimental Hypertension: CHE
Kyohei Misawa, Hajime Yasuda, Marito Araki, Tomonori Ochiai, Soji Morishita, Shuichi Shirane, Yoko Edahiro, Akihiko Gotoh, Akimichi Ohsaka, Norio Komatsu
The majority of patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) harbor JAK2, CALR, or MPL mutations. We compared clinical manifestations of different subtypes of JAK2 and CALR mutations in Japanese patients with MPNs. Within our cohort, we diagnosed 166 patients as polycythemia vera (PV), 212 patients as essential thrombocythemia (ET), 23 patients as pre-primary myelofibrosis (PMF), 65 patients as overt PMF, and 27 patients as secondary myelofibrosis following the 2016 WHO criteria...
February 20, 2018: International Journal of Hematology
Camille Lassale, Alyscia Curtis, Itziar Abete, Yvonne T van der Schouw, W M Monique Verschuren, Yunxia Lu, H B As Bueno-de-Mesquita
All blood cells (white blood cells [WBC], red blood cells [RBC] and platelets) can play a role in atherosclerosis. Complete blood count (CBC) is widely available in clinical practice but utility as potential risk factors for cardiovascular disease (CVD) is uncertain. Our aim was to assess the associations of pre-diagnostic CBC with incidence of CVD in 14,362 adults free of CVD and aged 47.8 (±11.7) years at baseline, followed-up for 11.4 years (992 incident cases). Cox proportional hazards regressions were used to estimate HRs and 95%CI...
February 19, 2018: Scientific Reports
Elisabeth Karsten, Edmond Breen, Benjamin R Herbert
Red blood cells (RBCs) have been shown to affect immune function and can induce inflammatory responses after transfusion. The transfusion of washed RBCs can significantly reduce adverse effects, however, the soluble factors that may mediate these effects have not been identified. Previous studies have identified, but not quantified, a small number of chemokines associated with RBCs. We isolated RBCs from healthy volunteers and quantified of a panel of 48 cytokines, chemokines, and growth factors in the lysate, cytosol, and conditioned media of these cells using Luminex® technology...
February 15, 2018: Scientific Reports
A Molina, L Guiñon, A Perez, A Segurana, J L Bedini, J C Reverter, A Merino
INTRODUCTION: It is important for clinical laboratories to maintain under control the possible sources of error in its analytical determinations. The objective of this work is to perform an analysis of the total error committed by laboratories using the data extracted from the Spanish External Quality Assessment Program in Hematology and to compare them with the specifications based on the biological variability proposed by the Ricós group. MATERIAL AND METHODS: We analyzed a total of 3 89 000 results during the period 2015-2016 from the following quantitative schemes of Spanish External Quality Assessment Program: complete blood count, blood coagulation tests, differential leukocyte count, reticulocytes, hemoglobin A2 , antithrombin, factor VIII, protein C, and von Willebrand factor...
February 5, 2018: International Journal of Laboratory Hematology
Preethi S Chari, Sujay Prasad
Image analysis based automated systems aiming to automate the manual microscopic review of peripheral blood smears have gained popularity in recent times. In this paper, we evaluate a new blood smear analysis system based on artificial intelligence, Shonit™ by SigTuple Technologies Private Limited. One hundred normal samples with no flags from an automated haematology analyser were taken. Peripheral blood smear slides were prepared using the autostainer integrated with an automated haematology analyser and stained using May-Grunwald-Giemsa stain...
January 2018: Indian Journal of Hematology & Blood Transfusion
N E Mohamed, S E Ashour
PURPOSE: The present study aimed to evaluate the protective role of "Morus alba Linn. (Family: Moraceae) commonly known as mulberry" leaves extract against hazardous effects of gamma rays in male rats. MATERIALS AND METHODS: Thirty six male albino rats were divided into six groups (6 rats/group); 1 - control group received 1 ml distilled water, 2- low dose of extract (100 mg/Kg) group treated daily with low oral dose of ethanolic extract of mulberry leaves (100 mg/kg body weight (b...
February 2, 2018: International Journal of Radiation Biology
Stephanie Grainger, David Traver, Karl Willert
Leukemia and lymphoma are a wide encompassing term for a diverse set of blood malignancies that affect people of all ages and result in approximately 23,000 deaths in the United States per year (Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66(1):7-30.). Hematopoietic stem cells (HSCs) are tissue-specific stem cells at the apex of the hierarchy that gives rise to all of the terminally differentiated blood cells, through progressively restricted progenitor populations, a process that is known to be Wnt-responsive...
January 2018: Progress in Molecular Biology and Translational Science
E Schapkaitz, S Raburabu
BACKGROUND: The automated Sysmex XN-9000 hematology system has been designed to meet the throughput and efficiency requirements of high volume laboratories with predominantly abnormal samples. New measurement channels have been introduced namely the white cell nucleated (WNR), white cell differential (WDF), white cell precursor (WPC) and fluorescent platelet (PLT-F) channels. METHODS: The performance of the new measurement channels was evaluated with regards to precision, accuracy, linearity, carryover, throughput and stability...
January 25, 2018: Clinical Biochemistry
Mun Hee Choi, Geun Hwa Park, Jin Soo Lee, Sung Eun Lee, Seong-Joon Lee, Jang-Hee Kim, Ji Man Hong
BACKGROUND AND PURPOSE: Recent advent of endovascular thrombectomy (EVT) enables us to provide a new perspective on the use of tPA (tissue-type plasminogen activator) through histological analysis of retrieved thrombus. We investigated the responsiveness of intravenous thrombolysis (IVT) according to the thrombus composition in EVT-attempted patients with acute ischemic stroke. METHODS: We reviewed 92 consecutive patients with anterior circulation stroke who received combined IVT and EVT for 2 years...
March 2018: Stroke; a Journal of Cerebral Circulation
X Yin, P Liu, B-Y Liu, Y-Y Liu, W-L Fan, J-H Zhao
OBJECTIVE: Deep vein thrombosis (DVT) is one of the most common complications for patients undergoing spinal surgery. This study aims to investigate preventive effects of low-molecular-weight heparin (LMWH) on the formation of DVT. PATIENTS AND METHODS: This study involved 37 patients who underwent spinal surgery between April 2016 and April 2017. Patients were divided into LMWH group and Control group. Clinical parameters, including operation time, intra-operative blood loss, incision length, post-operative visual analogue scale (VAS), exercise-time leaving bed and post-operative extubation time, were collected...
January 2018: European Review for Medical and Pharmacological Sciences
Nejat Siraj, John Issac, Mohammed Anwar, Yohannes Mehari, Shushan Russom, Semere Kahsay, Haben Frezghi
OBJECTIVES: Clinical laboratory reference intervals used in a specific area should be derived from the local population as they are influenced by many factors. The purpose of this quantitative cross sectional study was to establish hematological reference intervals for healthy adults in Asmara and to determine whether the currently used reference interval do represent the adult population in the city. In addition, the established reference intervals were compared to findings from similar studies conducted in selected countries in Africa...
January 22, 2018: BMC Research Notes
Morenike Agnes Akinlosotu, Samuel Ademola Adegoke, Saheed Babajide Oseni, Oluwagbemiga Oyewole Adeodu
BACKGROUND: Foetal haemoglobin (HbF, α2γ2) retards polymerisation of haemoglobin (Hb) in sickle cell anaemia (SCA). In Nigeria, studies on the levels of HbF and its relationship with haematological indices are scanty. This study evaluated HbF concentrations of children with SCA from Southwestern Nigeria and correlated the levels with various haematological indices. MATERIALS AND METHODS: HbF levels were quantified by high-performance liquid chromatography and haematological parameters determined with automated haemoanalyser...
October 2017: Nigerian Postgraduate Medical Journal
Yang Zeng, Michelle Dabay, Virginia George, Shalini Seetharaman, Monika de Arruda Indig, Sharon Graminske, Nicole Kimpel, Anna Schmidt, Amanda Boerner, Sarai Paradiso, Tatyana Delman, Yunyao Li, Viktoriya Litvak, Farzad Oreizy, Angela Chen, Maryam Saleminik, Fred Mosqueda, Anna Lin, Kevin Judge
The BD FACSVia™ System features novel designs in hardware, software, and instrument QC. We compared the performance of the BD FACSVia System using the BD Leucocount™ kit with the BD FACSCalibur™ flow cytometer. Leucoreduced platelet (PLT, n = 252) and red blood cell (RBC, n = 278) specimens were enrolled at four sites. Each specimen was stained in four tubes using the BD Leucocount kit reagents and acquired on the two systems. BD Leucocount Control cells (high and low) were used to evaluate the inter-site reproducibility on the BD FACSVia System at three sites over 20 days...
January 18, 2018: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"