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https://www.readbyqxmd.com/read/28742109/young-sprague-dawley-rats-infected-by-plasmodium-berghei-a-relevant-experimental-model-to-study-cerebral-malaria
#1
Sokhna Keita Alassane, Marie-Laure Nicolau-Travers, Sandie Menard, Olivier Andreoletti, Jean-Pierre Cambus, Noémie Gaudre, Myriam Wlodarczyk, Nicolas Blanchard, Antoine Berry, Sarah Abbes, David Colongo, Babacar Faye, Jean-Michel Augereau, Caroline Lacroux, Xavier Iriart, Françoise Benoit-Vical
Cerebral malaria (CM) is the most severe manifestation of human malaria yet is still poorly understood. Mouse models have been developed to address the subject. However, their relevance to mimic human pathogenesis is largely debated. Here we study an alternative cerebral malaria model with an experimental Plasmodium berghei Keyberg 173 (K173) infection in Sprague Dawley rats. As in Human, not all infected subjects showed cerebral malaria, with 45% of the rats exhibiting Experimental Cerebral Malaria (ECM) symptoms while the majority (55%) of the remaining rats developed severe anemia and hyperparasitemia (NoECM)...
2017: PloS One
https://www.readbyqxmd.com/read/28723945/haematological-and-cd4-t-cells-reference-ranges-in-healthy-adult-populations-in-gojjam-zones-in-amhara-region-ethiopia
#2
Wondemagegn Mulu, Bayeh Abera, Zewdie Mekonnen, Yesuf Adem, Mulat Yimer, Yohannes Zenebe, Asmare Amuamuta, Wondimu Gebeyehu
INTRODUCTION: Establishing national population haematological and immunological reference ranges are essential for clinical management of patients. However, there is scarcity of information on community based haematological reference ranges established from Ethiopian population. Therefore, this study aimed at determining haematological and CD4+ T cells reference ranges in healthy adults from East and West Gojjam zones, Ethiopia. METHODS: Community based cross-sectional study was conducted from May 2015 to December 2015 in healthy adult residents of Gojjam zone...
2017: PloS One
https://www.readbyqxmd.com/read/28718264/malignant-infantile-osteopetrosis
#3
Saima Gillani, Zaheer Abbas
Two main forms of osteopetrosis are recognized, a severe autosomal recessive form (MIM 259700) with an incidence of approximately 1 in 250,000 births and a mild autosomal dominant form (MIM166600) with an incidence of 1 in 20,000 births. Intrinsic disturbances of osteoclastic function due to mutations in genes encoding osteoclast-specific subunits of the vacuolar proton pump (TCIRG1, CLCN7) are found in most patients with recessive form. Mutations of CLCN7 are observed in dominant form of osteopetrosis .The recessive form of ostreopetrosis, i...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28694726/a-nationwide-multicentre-study-in-turkey-for-establishing-reference-intervals-of-haematological-parameters-with-novel-use-of-a-panel-of-whole-blood
#4
Yesim Ozarda, Kiyoshi Ichihara, Ebubekir Bakan, Harun Polat, Nurinnisa Ozturk, Nurcan K Baygutalp, Fatma Taneli, Yesim Guvenc, Murat Ormen, Zubeyde Erbayraktar, Nurten Aksoy, Hatice Sezen, Meltem Demir, Gulcin Eskandari, Gurbuz Polat, Nuriye Mete, Hatice Yuksel, Husamettin Vatansev, Fatma Gun, Okhan Akin, Ozlem Ceylan, Tevfik Noyan, Ozgul Gozlukaya, Yuksel Aliyazicioglu, Sevim Kahraman, Melahat Dirican, Gul Ozlem Tuncer, Shogo Kimura, Pinar Eker
INTRODUCTION: A nationwide multicentre study was conducted to establish well-defined reference intervals (RIs) of haematological parameters for the Turkish population in consideration of sources of variation in reference values (RVs). MATERIALS AND METHODS: K2-EDTA whole blood samples (total of 3363) were collected from 12 laboratories. Sera were also collected for measurements of iron, UIBC, TIBC, and ferritin for use in the latent abnormal values exclusion (LAVE) method...
June 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28693196/early-diagnosis-of-venous-thromboembolism-as-a-clinical-primary-symptom-of-occult-cancer-core-proteins-of-a-venous-thrombus
#5
Siwan Wen, Qianglin Duan, Fan Yang, Guiyuan Li, Lemin Wang
Malignancy is one of the risk factors of venous thromboembolism (VTE). As a common accompanying factor of malignant tumors, almost 20% of idiopathic VTEs are identified in patients with occult types of cancer as the primary symptom. The type of internal association that exists between malignant tumors and VTE has not yet been determined. The present review discusses the following: i) Reversible combinations between core proteins of venous thrombi and their ligand proteins. With the condition of immune cell balancing function collapse, which is characterized as dysfunction immune cells and impaired immune functions, the human body loses the function of eliminating infectious/malignant cells quickly and effectively...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28683066/a-pilot-study-evaluating-changes-to-haematological-and-biochemical-tests-after-flexible-ureterorenoscopy-for-the-treatment-of-kidney-stones
#6
Alyson Jayne Moyes, Rebecca May Lamb, Peter Ella-Tongwiis, Anish Pushkaran, Issam Ahmed, Iqbal Shergill, Stephen Fôn Hughes
BACKGROUND: Currently there is limited research documenting the changes in blood parameters, following Flexible Ureterorenoscopy. This study aims to determine whether there are any changes in haematology and biochemistry parameters, following Flexible Ureterorenoscopy for the treatment of kidney stones. METHODS: 40 consecutive patients aged between 27-87 years (median 49 years) undergoing Flexible Ureterorenoscopy for the treatment of kidney stones were recruited (26 male, 14 female)...
2017: PloS One
https://www.readbyqxmd.com/read/28679351/modulatory-effects-of-quercetin-on-liver-histopathological-biochemical-hematological-oxidative-stress-and-dna-alterations-in-rats-exposed-to-graded-doses-of-score-250
#7
Sabrine Kasmi, Intithar Bkhairia, Bahira Harrabi, Hela Mnif, Rim Marrakchi, Hanen Ghozzi, Choumous Kallel, Moncef Nasri, Khaled Zeghal, Kamel Jamoussi, Ahmed Hakim
This study investigated the morphological, biochemical and molecular aspects of liver injury in rats after the exposure to difenoconazole and the protective effects of quercetin against hepatotoxicity and genotoxicity induced by this fungicide. Rats were given graded doses of difenoconazole associated or not to quercetin daily for 20 days. Our results showed a significant increase in PLT (Platelets) and WBC (white blood cells) in rats treated with higher doses of difenoconazole (1/38 and 1/9 of LD50). However, a significant decrease in Hb (Hemoglobin) rate and RBC (Red blood cells) number in rats treated with higher doses of difenoconazole (1/38 and 1/9 of LD50) was obtained...
July 5, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28672770/performance-of-automated-digital-cell-imaging-analyzer-sysmex-di-60
#8
Hyeong Nyeon Kim, Mina Hur, Hanah Kim, Seung Wan Kim, Hee-Won Moon, Yeo-Min Yun
BACKGROUND: The Sysmex DI-60 system (DI-60, Sysmex, Kobe, Japan) is a new automated digital cell imaging analyzer. We explored the performance of DI-60 in comparison with Sysmex XN analyzer (XN, Sysmex) and manual count. METHODS: In a total of 276 samples (176 abnormal and 100 normal samples), white blood cell (WBC) differentials, red blood cell (RBC) classification and platelet (PLT) estimation by DI-60 were compared with the results by XN and/or manual count. RBC morphology between pre-classification and verification was compared according to the ICSH grading criteria...
June 16, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28657582/biocompatibility-of-hbv-liposome-encapsulated-hemoglobin-molecules-liposome-effects-on-immune-function
#9
REVIEW
Hiroshi Azuma, Mitsuhiro Fujihara, Hiromi Sakai
Hemoglobin vesicles (HbVs) are oxygen carriers consisting of Hb molecules and liposome in which human hemoglobin (Hb) molecules are encapsulated. Investigations of HbV biocompatibility have shown that HbVs have no significant effect on either the quality or quantity of blood components such as RBC, WBC, platelets, complements, or coagulation factors, reflecting its excellent biocompatibility. However, their effects on the immune system remain to be evaluated. HbVs might affect the function of macrophages because they accumulate in the reticuloendothelial system...
June 28, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28646487/immunotoxic-effects-of-thymus-in-mice-following-exposure-to-nanoparticulate-tio2
#10
Fashui Hong, Yaoming Zhou, Yingjun Zhou, Ling Wang
Titanium dioxide nanoparticles (TiO2 NPs) have been extensively used in industry, medicine, and daily life, and have shown potential toxic effects for animals or humans. We noted that the effects of TiO2 NPs on the immune system and its mechanism of action in animals or humans have not been elucidated. Thus, mice were exposed to the TiO2 NPs (0, 1.25, 2.5, or 5 mg kg(-1) body weight) for 9 consecutive months. Exposure to TiO2 NPs was accumulated in the thymus, leading to a decrease in body weight and increases in the weight of the thymus or thymus indices...
June 24, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28641617/-biological-characteristics-and-therapeutic-efficacy-of-103-patients-with-acute-erythroleukemia
#11
Yue Yin, Wen-Qi Zhan, Hui-Fang Huang, Chen-Qing Zhang, Dang-Hui Fu, Shu-Juan Xu, Jian-Da Hu, Xin-Ji Chen
OBJECTIVE: To investigate the biological characteristics and therapeutic efficacyt of acute erythroleukemia (AEL,AML-M6). METHODS: Blood cell count, liver function, lactate dehydrogenase level, coagulation, morphology, immunology, cell genetics and molecular biology were retrospectively analyzed in 103 cases of acute erythroleukemia patients admitted in our department from May 2016 to June 2009. The therapeutic efficacy was observed by means of remission rate, relapse rate, relapse-free survival and overall survival...
June 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28638159/in-vitro-evaluation-of-the-fresenius-kabi-catsmart-autotransfusion-system
#12
Melissa Alberts, Robert C Groom, Richard Walczak, Robert Kramer, Adrienne Karpiel, Jeanette Dieter, Lisa Sheth, Nathaniel H Greene, Edmund H Jooste
Use of autotransfusion systems to collect, wash, and concentrate shed blood during surgical procedures is a widely used method for reducing postoperative anemia and the need for blood transfusions. The aim of this study was to evaluate the CATSmart Continuous Autotransfusion System wash program performance with small (200 or 700 mL) and large volumes (1,000 mL) of shed blood and to determine non-inferiority of the CATSmart to the C.A.T.S (plus) system. Human whole blood was collected in citrate phosphate dextrose, diluted, and divided into two aliquots to be processed as a pair using the C...
June 2017: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/28613960/the-effect-of-air-pollution-on-diurnal-variation-of-performance-in-anaerobic-tests-cardiovascular-and-hematological-parameters-and-blood-gases-on-soccer-players-following-the-yo-yo-intermittent-recovery-test-level-1
#13
Nesrin Boussetta, Salma Abedelmalek, Khouloud Aloui, Nizar Souissi
This study aimed to investigate the effect of air pollution on diurnal variation of performance in anaerobic tests, cardiovascular and hematological parameters, and blood gases on soccer players following the Yo-Yo Intermittent Recovery Test Level-1 (YYIRT1). In a randomized order, 11 healthy soccer players (mean age: 21.8 [range: 20-24] years; height: 178.00 [range: 1.64-1.83] cm; body mass index [BMI]: 23.57 [range: 20.45-28.03] kg.m(-2)) performed a YYIRT1 at two different times of day (TOD) (08:00 h and 18:00 h) in two areas (i...
June 14, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28609750/association-of-plasma-cd40l-with-acute-chest-syndrome-in-sickle-cell-anemia
#14
Vanessa Tonin Garrido, Laura Sonzogni, Siana Nkya Mtatiro, Fernando F Costa, Nicola Conran, Swee Lay Thein
Platelet activation and platelet-derived cytokines contribute to the vascular inflammation and increased thrombotic activity known to occur in patients with sickle cell anemia (SCA). CD40 ligand (CD40L), a platelet-associated pro-inflammatory molecule that promotes endothelial cell activation, is elevated in the circulation of SCA patients. We sought to evaluate the association of CD40L and inflammation with sickle-related clinical complications and laboratory variables in SCA patients. Soluble CD40L, thrombospondin (TSP)-1 and tumor necrosis factor (TNF)-α were determined in the platelet-poor plasma of healthy individuals and steady-state SCA patients by ELISA...
June 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28605963/a-molecular-and-haematological-study-of-theileria-equi-in-balkan-donkeys
#15
Dajana Davitkov, Darko Davitkov, Milos Vucicevic, Ljubodrag Stanisic, Milena Radakovic, Uros Glavinic, Zoran Stanimirovic
Equine piroplasmosis in donkeys has been recognised as a serious problem of major economic importance. The present molecular study is the first investigation of the presence of Theileria equi and Babesia caballi in Balkan donkeys and of the possible haematological alterations related to it. A total of 70 apparently healthy donkeys from Serbia were included in this study. The overall prevalence of T. equi infection in donkeys tested with multiplex PCR was 50%. There was no B. caballi-positive sample. Infections in donkeys included in this study seem to be associated with decreased red blood cell count, haemoglobin concentration, haematocrit and platelet count, and with increased white blood cell count, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration...
June 2017: Acta Veterinaria Hungarica
https://www.readbyqxmd.com/read/28579856/estimation-of-platelet-counts-and-other-hematological-parameters-in-pseudothrombocytopenia-using-alternative-anticoagulant-magnesium-sulfate
#16
REVIEW
Chidambharam Choccalingam, Rajesh Kanna Nandagopal Radha, Nadella Snigdha
The platelet count, mean platelet volume, and other hematological parameters were compared in blood samples anticoagulated with MgSO4 and EDTA. A total of 15 samples were taken, and the platelet counts were observed to be significantly high in MgSO4-anticoagulated blood samples ranging from 53 × 10(3) to 499 × 10(3)/μL, whereas in EDTA-anticoagulated blood samples, the counts ranged from 10 × 10(3) to 353 × 10(3)/μL. This increased platelet count was also statistically significant with the P value being ...
2017: Clinical Medicine Insights. Blood Disorders
https://www.readbyqxmd.com/read/28559185/novel-dendritic-structure-of-alginate-hybrid-nanoparticles-for-effective-anti-viral-drug-delivery
#17
K S Joshy, Anne George, Jiya Jose, Nandakumar Kalarikkal, Laly A Pothen, Sabu Thomas
Lipid-polymer hybrid nanoparticles have recently gathered much attention as nanoplatforms for drug delivery applications due to their unique structural properties. In this study zidovudine (AZT) loaded hybrid nanoparticles of alginate (ALG) and stearic acid- poly ethylene glycol (SA-PEG) were synthesized. The structural characterization of drug loaded hybrid nanoparticles were studied using FT-IR spectroscopy, DLS and TEM analysis. These hybrid nanoparticles showed dendritic morphology and it can be used as an efficient carrier for zidovudine...
May 27, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28553755/cardiac-rehabilitation-in-patients-with-st-segment-elevation-myocardial-infarction-can-its-failure-be-predicted
#18
Robert Irzmański, Joanna Kapusta, Agnieszka Obrębska-Stefaniak, Beata Urzędowicz, Jan Kowalski
BACKGROUND: The prognosis in patients after acute coronary syndromes (ACS) is significantly burdened by coexisting anaemia, leukocytosis and low glomerular filtration rate (GFR). Hyperglycaemia in the early stages of ACS is a strong predictor of death and heart failure in non-diabetic subjects. This study aimed to evaluate the effect of hyperglycaemia, anaemia, leukocytosis, thrombocytopaenia and decreased GFR on the risk of the failure of cardiac rehabilitation (phase II at the hospital) in post-ST-segment elevation myocardial infarction (STEMI) patients...
July 2017: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/28511299/-value-of-dna-content-in-comet-tail-in-predicting-changes-in-blood-cell-counts-in-workers-exposed-to-benzene
#19
B X Liang, X X Liu, L P Chen, A C Yang, M Huang, Q F Deng, W Chen, Y M Xiao
Objective: To investigate the value of DNA content in comet tail (TailDNA) in predicting the changes in peripheral blood cell counts in workers exposed to benzene. Methods: In 2011, cluster sampling was used to select 150 male workers exposed to benzene in a petrochemical factory. Cubital venous blood and urine samples were collected for routine blood rest, comet assay, and measurement of s-phenylmercapturic acid (SPMA) and urine creatinine. The population was divided into groups according to urinary SPMA or TailDNA, and routine blood test results within 3 years were collected to analyze the changes in blood cell counts...
March 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28496093/prediction-of-new-onset-and-recurrent-atrial-fibrillation-by-complete-blood-count-tests-a-comprehensive-systematic-review-with-meta-analysis
#20
Alexander Weymann, Sadeq Ali-Hasan-Al-Saegh, Anton Sabashnikov, Aron-Frederik Popov, Seyed Jalil Mirhosseini, Tong Liu, Mohammadreza Lotfaliani, Michel Pompeu Barros de Oliveira Sá, William L L Baker, Senol Yavuz, Mohamed Zeriouh, Jae-Sik Jang, Hamidreza Dehghan, Lei Meng, Luca Testa, Fabrizio D'Ascenzo, Umberto Benedetto, Gary Tse, Luis Nombela-Franco, Pascal M Dohmen, Abhishek J Deshmukh, Cecilia Linde, Giuseppe Biondi-Zoccai, Gregg W Stone, Hugh Calkins, Integrated Meta-Analysis Of Cardiac Surgery And Cardiology-Group Imcsc-Group
BACKGROUND Atrial fibrillation (AF) is one of the most critical and frequent arrhythmias precipitating morbidities and mortalities. The complete blood count (CBC) test is an important blood test in clinical practice and is routinely used in the workup of cardiovascular diseases. This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of hematological parameters in the CBC test with new-onset and recurrent AF. MATERIAL AND METHODS We conducted a meta-analysis of observational studies evaluating hematologic parameters in patients with new-onset AF and recurrent AF...
May 12, 2017: Medical Science Monitor Basic Research
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